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https://www.readbyqxmd.com/read/28633683/plasminogen-activator-inhibitor-1-is-regulated-through-dietary-fat-intake-and-heritability-studies-in-twins
#1
Anna Janina Engstler, Turid Frahnow, Michael Kruse, Andreas Friedrich Hermann Pfeiffer, Ina Bergheim
In different pathophysiological conditions plasminogen activator inhibitor-1 (PAI-1) plasma concentrations are elevated. As dietary patterns are considered to influence PAI-1 concentration, we aimed to determine active PAI-1 plasma concentrations and mRNA expression in adipose tissue before and after consumption of a high-fat diet (HFD) and the impact of additive genetic effects herein in humans. For 6 weeks, 46 healthy, non-obese pairs of twins (aged 18-70) received a normal nutritionally balanced diet (ND) followed by an isocaloric HFD for 6 weeks...
June 21, 2017: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://www.readbyqxmd.com/read/28632884/components-of-the-alternative-complement-pathway-in-patients-with-psoriasis
#2
Betul Sereflican, Guler Bugdayci
INTRODUCTION: Psoriasis is a chronic inflammatory skin disease. Adipose tissue plays important roles in the events that regulate body metabolism. This study determined the levels of complement 3 ( C3), acylation-stimulating protein (ASP), and adipsin, which take part in the alternate complement pathway, and are synthesized in and secreted by adipose tissue. METHODS: Thirty-two patients with psoriasis were matched with 22 controls in terms of age, sex, body mass index, and lipid profiles...
June 2017: Acta Dermatovenerologica Alpina, Panonica, et Adriatica
https://www.readbyqxmd.com/read/28632647/high-osteogenic-potential-of-adipose-and-muscle-derived-mesenchymal-stem-cells-in-spinal-ossification-model-mice
#3
Xizhe Liu, Gentaro Kumagai, Kanichiro Wada, Toshihiro Tanaka, Toru Asari, Kazuki Oishi, Taku Fujita, Hiroki Mizukami, Ken-Ichi Furukawa, Yasuyuki Ishibashi
STUDY DESIGN: Basic experiments in a mouse model of ossification of the posterior longitudinal ligament (OPLL). OBJECTIVE: To assess the osteogenic potential of mesenchymal stem cells (MSCs) obtained from muscle and adipose tissue in Tiptoe-walking (ttw) mice, in which cervical OPLL compresses the spinal cord and causes motor and sensory dysfunction. SUMMARY OF BACKGROUND DATA: In humans, MSCs have been implicated in the pathogenesis of cervical OPLL...
June 19, 2017: Spine
https://www.readbyqxmd.com/read/28632304/are-visceral-adiposity-index-and-lipid-accumulation-product-reliable-indices-for-metabolic-disturbances-in-patients-with-type-2-diabetes-mellitus
#4
Nebojsa Kavaric, Aleksandra Klisic, Ana Ninic
BACKGROUND: Visceral adiposity index (VAI) and Lipid accumulation product (LAP) are novel visceral adiposity indexes, proposed for the evaluation of cardiometabolic risk in adult population. Considering contradictory results obtained from many studies so far, we aimed to examine the potential benefit of applicability of VAI and LAP, over simple anthropometric indices and traditional lipid parameters in individuals with type 2 diabetes mellitus (DM2). METHODS: A total of 180 DM2 (of them 50% females) and 119 controls who volunteered to participate in this cross-sectional study were enrolled...
June 20, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28631813/high-fat-diet-attenuates-hyperglycemia-body-composition-changes-and-bone-loss-in-male-streptozotocin-induced-type-1-diabetic-mice
#5
Adriana Lelis Carvalho, Victoria E DeMambro, Anyonya R Guntur, Phuong Le, Kenichi Nagano, Roland Baron, Francisco José Albuquerque de Paula, Katherine J Motyl
There is a growing and alarming prevalence of obesity and the metabolic syndrome in type I diabetic patients (T1DM), particularly in adolescence. In general, low bone mass, higher fracture risk and increased marrow adipose tissue (MAT) are features of diabetic osteopathy in insulin deficient subjects. On the other hand, type 2 diabetes (T2DM) is associated with normal or high bone mass, a greater risk of peripheral fractures and no change in MAT. Therefore, we sought to determine the effect of weight gain on bone turnover in insulin deficient mice...
June 20, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28628810/gh-administration-decreases-subcutaneous-abdominal-adipocyte-size-in-men-with-abdominal-obesity
#6
Miriam A Bredella, Kalypso Karastergiou, Stijn A Bos, Anu V Gerweck, Martin Torriani, Susan K Fried, Karen K Miller
OBJECTIVE: To investigate the effects of short-term GH administration on abdominal subcutaneous adipocyte size and CT attenuation in men with abdominal obesity. DESIGN: 6-week, randomized, double-blind, placebo-controlled study of GH (starting dose 2μg/kg/d) vs placebo of 15 abdominally obese men (mean age: 34±6years; mean BMI: 37.7±6.1kg/m(2), mean IGF-1 SDS: -1.9±0.5) who underwent abdominal subcutaneous adipose tissue (SAT) aspirations to determine adipocyte size, CTs for body composition and measures of glucose tolerance at baseline and 6weeks...
June 12, 2017: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/28628798/maternal-liver-docosahexaenoic-acid-dha-stores-are-increased-via-higher-serum-unesterified-dha-uptake-in-pregnant-long-evans-rats
#7
Adam H Metherel, Alex P Kitson, Anthony F Domenichiello, R J Scott Lacombe, Kathryn E Hopperton, Marc-Olivier Trépanier, Shoug M Alashmali, Lin Lin, Richard P Bazinet
Maternal docosahexaenoic acid (DHA, 22:6n-3) supplies the developing fetus during pregnancy; however, the mechanisms are unclear. We utilized pregnant rats to determine rates of DHA accretion, tissue unesterified DHA uptake and whole-body DHA synthesis-secretion. Female rats maintained on a DHA-free, 2% α-linolenic acid diet were either:1) sacrificed at 56 days for baseline measures, 2) mated and sacrificed at 14-18 days of pregnancy or 3) or sacrificed at 14-18 days as age-matched virgin controls. Maternal brain, adipose, liver and whole body fatty acid concentrations was determined for balance analysis, and kinetic modeling was used to determine brain and liver plasma unesterified DHA uptake and whole-body DHA synthesis-secretion rates...
June 1, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28628145/-relationship-between-glycemic-control-and-visceral-adiposity-index-among-the-patients-with-type-2-diabetes-mellitus
#8
Y Y Cao, X Tang, K X Sun, Z K Liu, X Xiang, J Juan, J Song, Q Z Duan, D J Zhaxi, Y N Hu, Y F Yang, M Y Shi, Y H Tian, S P Huang, X F Liu, N Li, J Li, T Wu, D F Chen, Y H Hu
OBJECTIVE: To explore the relationship between glycemic control and visceral adiposity index (VAI) among type 2 diabetes mellitus (T2DM) patients. METHODS: A community-based epidemiological field study for patients with T2DM aged ≥ 40 years was conducted in China.Every participant underwent physical examinations, biochemical tests of fasting glucose, glycosylated hemoglobin (HbA1c), total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and so on, and a questionnaire, including anthropometric characteristics, lifestyle, disease history, family history, and medication use...
June 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28626215/genetic-variation-in-the-obesity-gene-fto-is-not-associated-with-decreased-fat-oxidation-the-neo-study
#9
L L Blauw, R Noordam, S Trompet, J F P Berbée, F R Rosendaal, D van Heemst, K W van Dijk, D O Mook-Kanamori, R de Mutsert, P C N Rensen
BACKGROUND: The FTO gene harbours the strongest common genetic variant associated with obesity. Recently, rs1421085-T to -C substitution mapped in FTO was shown to induce a developmental shift of human adipocytes from an energy-combusting beige to an energy-storing white phenotype in vitro. As browning of adipocytes selectively enhances fat oxidation (FatOx), we hypothesized that rs1421085-C in FTO is associated with deceased FatOx compared with carbohydrate oxidation (CarbOx) and an increased respiratory quotient (RQ)...
June 19, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28624818/maternal-subcutaneous-and-visceral-adipose-ultrasound-thickness-in-women-with-gestational-diabetes-mellitus-at-24-28-weeks-gestation
#10
Francesco D'Ambrosi, Francesca Crovetto, Enrico Colosi, Isabella Fabietti, Floriana Carbone, Beatrice Tassis, Silvia Motta, Alessandro Bulfoni, Luigi Fedele, Gabriele Rossi, Nicola Persico
OBJECTIVE: To compare the sonographic measurement of maternal subcutaneous and visceral adipose thickness between pregnant women with gestational diabetes mellitus (GDM) and patients with nondiabetic pregnancies. METHODS: Adipose thickness was measured by transabdominal ultrasound in pregnant women attending our antenatal clinics at 24-28 weeks' gestation. All patients underwent a 75-g oral glucose challenge as a diagnostic test for GDM. RESULTS: The study population comprised 56 women with a positive glucose challenge test and 112 nondiabetic pregnancies...
June 17, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28623445/laparoscopic-sleeve-gastrectomy-resolves-low-ghrp-2-stimulated-growth-hormone-levels-in-obese-patients
#11
Emi Ohara, Hirotake Tokuyama, Takumi Kitamoto, Aya Kitahara, Aiko Hayashi, Hideki Hayashi, Minoru Takemoto, Koutaro Yokote
Because growth hormone (GH) secretion is reportedly decreased in obese patients, we examined not only the factors associated with the decreased GH secretion but also GH response to the GH-releasing peptide (GHRP)-2-load test before and after laparoscopic gastrectomy (LSG). The study comprised 28 individuals aged 19-65 years [mean body mass index (BMI), 39.4 ± 9.4 kg/m(2)]. In the univariate analysis, GH secretion peaks correlated negatively with BMI (r = -0.59, p = 0.001), visceral adipose tissue (r = -0...
June 16, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28623055/prevalence-of-adiposity-and-its-association-with-sleep-duration-quality-and-timing-among-9-12-year-old-children-in-guangzhou-china
#12
Jiao Wang, Peymane Adab, Weijia Liu, Yajun Chen, Bai Li, Rong Lin, Wei Liu, Kar Keung Cheng, Miranda Pallan
BACKGROUND: Short sleep duration has been reported to be associated with obesity in children, but findings are not consistent. Since few studies have examined the relationship between more complex sleep characteristics and obesity, we examined the association between adiposity and self-reported sleep duration, bedtime, and sleep quality in 9-12-year-old Chinese children using multilevel mixed models. METHODS: 5518 children aged 9-12 years were recruited from 29 randomly selected primary schools in Guangzhou, China in 2014...
June 13, 2017: Journal of Epidemiology
https://www.readbyqxmd.com/read/28622077/a-comparative-study-of-the-effects-of-sodium-selenite-and-glutathione-mono-ethyl-ester-on-aged-adipose-derived-stem-cells-the-telomerase-and-cellular-responses
#13
N Aminizadeh, Taki M Tiraihi, S A Mesbah-Namin, Taher Taheri
The proliferation and differentiation potential of adipose derived stem cells (ADSCs) declines with ageing. Moreover, Alzheimer's disease is associated with progressive decline in cholinergic neurons. The purpose of this study is to enhance the proliferation potential of aged rat ADSCs and their differentiation into cholinergic neurons. The ADSCs were collected from aged male rats cultured and treated with different concentrations of sodium selenite for 3 days or glutathione mono ethyl ester (GSH-MEE) for 1 day...
June 16, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28619255/infant-nutrition-and-maternal-obesity-influence-the-risk-of-non-alcoholic-fatty-liver-disease-in-adolescents
#14
Oyekoya T Ayonrinde, Wendy H Oddy, Leon A Adams, Trevor A Mori, Lawrence J Beilin, Nicholas de Klerk, John K Olynyk
BACKGROUND & AIMS: The pathway to non-alcoholic fatty liver disease (NAFLD) in adolescents may have its origins in adiposity gains, nutrition and sedentary lifestyle established during childhood. There is inadequate knowledge regarding the associations between infant nutrition and subsequent NAFLD. We examined the association of maternal factors and infant nutrition, with the subsequent diagnosis of NAFLD in adolescents. METHODS: Adolescents aged 17years in the Western Australian Pregnancy (Raine) Cohort study had fatty liver assessment using liver ultrasound...
May 22, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28619249/metabolism-of-sex-steroids-is-influenced-by-acquired-adiposity-a-study-of-young-adult-male-monozygotic-twin-pairs
#15
Veera Vihma, Jussi Naukkarinen, Ursula Turpeinen, Esa Hämäläinen, Jaakko Kaprio, Aila Rissanen, Sini Heinonen, Antti Hakkarainen, Jesper Lundbom, Nina Lundbom, Tomi S Mikkola, Matti J Tikkanen, Kirsi H Pietiläinen
Obesity and ageing are associated with lower serum testosterone levels in men. How fat distribution or adipose tissue metabolism, independent of genetic factors and age, are related to sex steroid metabolism is less clear. We studied the associations between adiposity and serum sex hormone concentrations, and mRNA expression of genes regulating sex hormone metabolism in adipose tissue in young adult male monozygotic (MZ) twin pairs. The subjects [n=18 pairs; mean age, 32 years; individual body mass indexes (BMIs) 22-36kg/m(2)] included 9 male MZ twin pairs discordant for BMI [intra-pair difference (Δ) in BMI ≥3kg/m(2)]...
June 12, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28616806/ipragliflozin-reduces-epicardial-fat-accumulation-in-non-obese-type-2-diabetic-patients-with-visceral-obesity-a-pilot-study
#16
Tatsuya Fukuda, Ryotaro Bouchi, Masahiro Terashima, Yuriko Sasahara, Masahiro Asakawa, Takato Takeuchi, Yujiro Nakano, Masanori Murakami, Isao Minami, Hajime Izumiyama, Koshi Hashimoto, Takanobu Yoshimoto, Yoshihiro Ogawa
INTRODUCTION: Epicardial fat (EF) was reported to be independently associated with cardiovascular disease regardless of obesity. We have previously reported that a sodium-glucose co-transporter-2 (SGLT2) inhibitor, luseogliflozin, reduces the EF volume (EFV) in parallel with the reduction of body weight in obese patients (BMI ≥25 kg/m(2)) with type 2 diabetes. However, it is unknown whether SGLT2 inhibitors could reduce EFV in non-obese patients (BMI <25 kg/m(2)) with type 2 diabetes...
June 14, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/28612522/-the-mechanisms-of-trimetazidine-alleviating-the-oxidative-stress-in-adipose-derived-mesenchymal-stem-cells
#17
Mao-Han Tang, Yan-Jie Zhang, Yin Liu, Zhi-Guang Su
OBJECTIVES: To investigate the effects of trimetazidine (TMZ) on the oxidative stress injury in adipose-derived mesenchymal stem cells (ADSCs). METHODS: ADSCs derived from adipose tissue of SD rats were characterized by flow cytometry and multiline age differentiation. ADSCs apoptosis was induced by H2O2 in vitro , Dirrerent concentration of TMZ (250 μmol/L, 500 μmol/L) was used to protect ADSCs from apoptosis. The morphological features of apoptotic ADSCs were analyzed by Hoechst 33342, mitochondrial potential and structure was analyzed by JC-1 staining and electron microscope, respectively...
March 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28611943/association-between-serum-thyroid-stimulating-hormone-levels-and-visceral-adipose-tissue-a-population-based-study-in-northeast-germany
#18
Tilman Witte, Henry Völzke, Markus M Lerch, Katrin Hegenscheid, Nele Friedrich, Till Ittermann, John A Batsis
BACKGROUND: Abdominal obesity is a major driver for adverse medical conditions. While an interaction between adipose tissue and thyroid function is thought to exist, to our knowledge, no study has examined the effect of thyroid-stimulating hormone (TSH) on visceral adipose tissue (VAT) in a population-based context. OBJECTIVE: We determined an association between serum TSH levels and VAT. METHODS: A sample of 1,021 female and 956 male adults aged 20-79 years was drawn from registry offices in the cross-sectional, population-based Study of Health in Pomerania Trend (SHIP Trend) in Northeast Germany from 2008 to 2012...
February 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/28608606/waist-to-height-ratio-and-its-association-with-tv-viewing-in-a-sample-of-portuguese-children-aged-7-9-years
#19
Aristides M Machado-Rodrigues, João Valente-Dos-Santos, Romulo Fernandes, Augusta Gama, Isabel Mourao, Helena Nogueira, Vitor Marques, Cristina Padez
INTRODUCTION: During the past decades, increased TV viewing and reduced physical activity (PA) levels may have contributed to the increased prevalence of pediatric obesity. This study aimed to analyze the association between TV viewing and central adiposity risk in Portuguese children. METHODS: The sample comprised 3987 children (1997 girls and 1990 boys) aged 7-9 years. Height, weight, and waist circumference (WC) were measured. Waist-to-height ratio (WHtR) was calculated as the ratio of waist/height with a cut-off of 0...
June 13, 2017: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/28605451/age-at-menarche-and-incidence-of-diabetes-a-prospective-study-of-300-000-women-in-china
#20
Ling Yang, Liming Li, Sanne A E Peters, Robert Clarke, Yu Guo, Yiping Chen, Zheng Bian, Paul Sherliker, Jiyuan Yin, Zhenzhu Tang, Chunmei Wang, Xiaohuan Wang, Libo Zhang, Mark Woodward, Zhengming Chen
Previous studies of mostly Western populations have reported inconsistent associations between age at menarche and risk of diabetes. We examined such associations among Chinese women who tend to have later menarche age than women in West. China Kadoorie Biobank recruited 302,632 women aged 30-79 years from 10 areas across China in 2004-8, recording 5,391 incident cases of diabetes during 7-years follow-up among 270,345 women without diabetes, cardiovascular disease or cancer at baseline. Cox regression models yielded adjusted hazard ratios (HRs) for incident diabetes associated with age at menarche...
June 9, 2017: American Journal of Epidemiology
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