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https://www.readbyqxmd.com/read/29444356/long-chain-polyunsaturated-fatty-acids-decline-rapidly-in-milk-from-mothers-delivering-extremely-preterm-indicating-the-need-for-supplementation
#1
Anders K Nilsson, Chatarina Löfqvist, Svetlana Najm, Gunnel Hellgren, Karin Sävman, Mats X Andersson, Lois E H Smith, Ann Hellström
AIM: Our aim was perform an in-depth analysis of the composition of fatty acids in milk from mothers delivering extremely preterm babies. We investigated longitudinal changes in milk fatty acid profiles and the relationship between several types of fatty acids, including omega-3 and omega-6. METHODS: Milk samples were collected at three stages of lactation from 78 mothers who delivered at less than 28 weeks of pregnancy at the Sahlgrenska University Hospital, Gothenburg, Sweden, from April 2013 to September 2015...
February 14, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29442454/higher-concentrations-of-osteoprotegerin-in-type-1-diabetic-patients-are-related-to-retinopathy-results-from-the-pozna%C3%A5-prospective-study
#2
Agata Grzelka, Dariusz Naskręt, Aleksandra Araszkiewicz, Aleksandra Uruska, Małgorzata Wegner, Dorota Zozulińska-Ziółkiewicz
BACKGROUND: Osteoprotegerin (OPG) is an arterial calcification marker which has been associated with vascular damage. Elevated OPG concentrations associated with low-grade inflammatory processes are found in diabetic subjects. OBJECTIVES: The aim of the study was to assess concentrations of OPG in relation to the presence of diabetic complications in patients with diabetes type 1 (DM 1) participating in the Poznań Prospective Study (PoProStu). MATERIAL AND METHODS: The study included 74 patients with DM1 (48 men) with a median age of 39 years (interquartile range [IQR]: 34-43) and a median 15-year history (IQR: 14-16) of diabetes, who were participants in the PoProStu...
December 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29441738/the-first-reported-case-of-fibrous-hamartoma-of-infancy-with-hyperhidrosis-and-hypertrichosis-in-korea
#3
Moon Hyung You, Dong Hoon Shin, Jong Soo Choi, Byeong Su Kim, Yeonwoong Kim, JoonGoon Kim
Fibrous hamartoma of infancy (FHI) is a rare entity with a benign nature. The typical clinical features are a single, slowly growing, painless mass on the trunk that appears within the first 2 years of life. We report a 13-month-old boy who presented with a plaque on the lower back since 4 months of age. The plaque had gradually become larger and firm, and hyperhidrosis and hypertrichosis were noticed. No visible connection between the spinal cord and the lesion was found in radiologic studies, indicating a disease other than spinal dysraphism...
February 26, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29440390/high-dietary-fat-and-sucrose-results-in-an-extensive-and-time-dependent-deterioration-in-health-of-multiple-physiological-systems-in-mice
#4
James G Burchfield, Melkam A Kebede, Christopher C Meoli, Jacqueline Stöckli, P Tess Whitworth, Amanda L Wright, Nolan J Hoffman, Annabel Y Minard, Xiuquan Ma, James R Krycer, Marin E Nelson, Shi-Xiong Tan, Belinda Yau, Kristen C Thomas, Natalie K Y Wee, Ee-Cheng Khor, Ronaldo F Enriquez, Bryce Vissel, Trevor J Biden, Paul A Baldock, Kyle L Hoehn, James Cantley, Gregory J Cooney, David E James, Daniel J Fazakerley
Obesity is associated with metabolic dysfunction, including insulin resistance and hyperinsulinemia, and with disorders such as cardiovascular disease, osteoporosis, and neurodegeneration. Typically, these pathologies are examined in discrete model systems and with limited temporal resolution, and whether these disorders co-occur is therefore unclear. To address this question, we examined multiple physiological systems in male C57BL/6J mice following prolonged exposure to a high-fat/high-sucrose diet (HFHSD)...
February 13, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29440011/different-weight-histories-and-risk-of-incident-coronary-heart-disease-and-stroke-tehran-lipid-and-glucose-study
#5
Maryam Kabootari, Samaneh Asgari, Mohammad Ali Mansournia, Davood Khalili, Majid Valizadeh, Fereidoun Azizi, Farzad Hadaegh
BACKGROUND: This study aimed to determine the association between different weight histories, including cumulative excess weight, cumulative excess waist circumference (WC), duration of general and central adiposity, current and maximum body mass index, and current and maximum WC, and incident coronary heart disease (CHD) and stroke. METHODS AND RESULTS: The study population consisted of 4398 adults aged ≥40 years without CHD or stroke at baseline. Associations between different weight histories and CHD and stroke were determined by multivariable time-varying Cox regression models after adjustment for age, sex, and time-varying confounders...
February 10, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29439878/thickness-and-an-altered-mirna-expression-in-the-epicardial-adipose-tissue-is-associated-with-coronary-heart-disease-in-sudden-death-victims
#6
Josep Marí-Alexandre, Moises Barceló-Molina, Jorge Sanz-Sánchez, Pilar Molina, Jennifer Sancho, Yolanda Abellán, María Luisa Santaolaria-Ayora, Juan Giner, Luis Martínez-Dolz, Amparo Estelles, Aitana Braza-Boïls, Esther Zorio
INTRODUCTION AND OBJECTIVES: An increased epicardial adipose tissue (EAT) thickness has become a new risk factor for coronary heart disease (CHD). We aimed to study the role of EAT dysfunction as a CHD marker by focusing on its thickness and microRNA (miRNA) expression profile, and the potential factors possibly influencing them. METHODS: One hundred and fifty-five CHD sudden cardiac death victims and 84 non-CHD-sudden death controls were prospectively enrolled at autopsy...
February 10, 2018: Revista Española de Cardiología
https://www.readbyqxmd.com/read/29439189/socioeconomic-inequality-in-recovery-from-poor-physical-and-mental-health-in-mid-life-and-early-old-age-prospective-whitehall-ii-cohort-study
#7
REVIEW
Akihiro Tanaka, Martin J Shipley, Catherine A Welch, Nora E Groce, Michael G Marmot, Mika Kivimaki, Archana Singh-Manoux, Eric J Brunner
BACKGROUND: Few studies have examined the influence of socioeconomic status on recovery from poor physical and mental health. METHODS: Prospective study with four consecutive periods of follow-up (1991-2011) of 7564 civil servants (2228 women) recruited while working in London. Health was measured by the Short-Form 36 questionnaire physical and mental component scores assessed at beginning and end of each of four rounds. Poor health was defined by a score in the lowest 20% of the age-sex-specific distribution...
February 8, 2018: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/29438687/increased-apob-apoa1-ratio-is-associated-with-excess-weight-body-adiposity-and-altered-lipid-profile-in-children
#8
Ana Paula Pereira Castro, Helen Hermana Miranda Hermsdorff, Luana Cupertino Milagres, Fernanda Martins Albuquerque, Mariana de Santis Filgueiras, Naruna Pereira Rocha, Juliana Farias de Novaes
OBJECTIVE: To investigate ApoB/ApoA1 ratio and its association with cardiovascular risk factors in children. METHODS: Cross-sectional study with 258 children aged 8 and 9 years old, enrolled in all urban schools in the city of Viçosa-MG. An anthropometric evaluation of the body and biochemical composition of the children was performed. Socioeconomic variables and sedentary lifestyle were evaluated through a semi-structured questionnaire. RESULTS: Many children had excess weight (35...
February 10, 2018: Jornal de Pediatria
https://www.readbyqxmd.com/read/29438496/the-adiponectin-paradox-in-the-elderly-associations-with-body-composition-physical-functioning-and-mortality
#9
Joshua F Baker, Anne B Newman, Alka Kanaya, Mary B Leonard, Babette Zemel, Iva Miljkovic, Jin Long, David Weber, Tamara B Harris
Background: To determine if adiponectin levels are associated with weight loss, low muscle mass, and physical functioning among the elderly and to determine independent associations with incident disability and death. Methods: Included were 3,044 participants from the Health, Aging and Body Composition Study who had whole-body dual energy absorptiometry performed to evaluate appendicular lean mass index (ALMI, kg/m2) and fat mass index (FMI, kg/m2), CT measures of thigh muscle density, weight histories, estimates of physical functioning, and adiponectin levels at enrollment...
February 9, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29437880/molecular-regulation-of-follicle-stimulating-hormone-synthesis-secretion-and-action
#10
Nandana Das, Rajendra Kumar
Follicle-stimulating hormone (FSH) plays fundamental roles in male and female fertility. FSH is a heterodimeric glycoprotein expressed by gonadotrophs in the anterior pituitary. The hormone-specific FSH-subunit is non-covalently associated with the common -subunit that is also present in the luteinizing hormone (LH), another gonadotrophic hormone secreted by gonadotropes and thyroid-stimulating hormone (TSH) secreted by thyrotrophs. Several decades of research led to the purification, structural characterization and physiological regulation of FSH in a variety of species including humans...
February 7, 2018: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/29437161/associations-of-adult-genetic-risk-scores-for-adiposity-with-childhood-abdominal-liver-and-pericardial-fat-assessed-by-magnetic-resonance-imaging
#11
C Monnereau, S Santos, A van der Lugt, V W V Jaddoe, J F Felix
BACKGROUND: Genome-wide association studies (GWASs) identified single-nucleotide polymorphisms (SNPs) involved in adult fat distribution. Whether these SNPs also affect abdominal and organ-specific fat accumulation in children is unknown. METHODS: In a population-based prospective cohort study among 1995 children (median age: 9.8 years, 95% range 9.4-10.8), we tested the associations of six genetic risk scores based on previously identified SNPs for childhood body mass index (BMI), adult BMI, liver fat, waist-hip ratio, pericardial fat mass, visceral and subcutaneous adipose tissue ratio (VAT/SAT ratio) and four individual SAT- and VAT-associated SNPs for association with SAT (N=1746), VAT (N=1742), VAT/SAT ratio (N=1738), liver fat fraction (N=1950) and pericardial fat mass (N=1803) measured by magnetic resonance imaging...
December 7, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29436650/toll%C3%A2-like-receptor-2-mediates-deposition-of-collagen-i-in-adipose-tissue-of-high-fat-diet%C3%A2-induced-obese-mice
#12
Bing Song, Haoqiang Zhang, Suping Zhang
Obesity is marked by deposition of collagen I in adipose tissue. Toll like receptor (TLR)2 is involved in lipid metabolism, however the association between TLR2 and collagen I remains unclear. The present study was designed to investigate the effect of TLR2 knockout on collagen I in adipose tissue in obese mice. TLR2 knockout and C57BL/6J mice (aged 4 weeks) were fed normal chow or a high‑fat‑diet for 16 weeks. Compared with adipose tissue from lean controls, that from C57BL/6J mice fed a high‑fat diet had increased levels of collagen I, TIMP1 and TGFβ1 and lower levels of MMP1...
February 12, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29435946/ethnic-variations-in-adiponectin-levels-and-its-association-with-age-gender-body-composition-and-diet-differences-between-iranians-indians-and-europeans-living-in-australia
#13
Majid Meshkini, Fariba Alaei-Shahmiri, Cyril Mamotte, Jaya Dantas
Adiponectin is an adipocyte-derived protein with anti-diabetic, anti-atherogenic and anti-inflammatory action, but there are few studies on its association with cardiovascular and metabolic risk factors in different ethnic groups in Australia. This cross-sectional study evaluated ethnic differences in adiponectin levels and its association with age, gender, body composition and diet in 89 adult Australians of European (n = 28), Indian (n = 28) and Iranian (n = 33) ancestries. Different measures of adiposity were assessed using the method of whole body dual energy X-ray absorptiometry (DEXA)...
February 12, 2018: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/29433433/epicardial-adipose-tissue-is-related-to-arterial-stiffness-and-inflammation-in-patients-with-cardiovascular-disease-and-type-2-diabetes
#14
Shaween Al-Talabany, Ify Mordi, J Graeme Houston, Helen M Colhoun, Jonathan R Weir-McCall, Shona Z Matthew, Helen C Looker, Daniel Levin, Jill J F Belch, Fiona Dove, Faisel Khan, Chim C Lang
BACKGROUND: Epicardial adipose tissue (EAT) is an emerging cardio-metabolic risk factor and has been shown to correlate with adverse cardiovascular (CV) outcome; however the underlying pathophysiology of this link is not well understood. The aim of this study was to evaluate the relationship between EAT and a comprehensive panel of cardiovascular risk biomarkers and pulse wave velocity (PWV) and indexed left ventricular mass (LVMI) in a cohort of patients with cardiovascular disease (CVD) and diabetes compared to controls...
February 13, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29431910/lipomatoses
#15
Philipp Al Ghazal, Lisa-Lena Grönemeyer, Michael P Schön
Lipomatoses are benign proliferations of adipose tissue, often with typical distribution patterns, which usually occur without clear causes. In contrast to circumscribed lipomas, they develop diffusely and symmetrically and are not surrounded by a fibrous pseudocapsule. The most common form is benign symmetric lipomatosis (BSL; Launois-Bensaude syndrome), of which four types are distinguished based on the distribution pattern of hyperplastic adipose tissue. The etiology and pathogenesis of the disease are still largely unknown, although some forms appear to have a hereditary basis or to be associated with increased alcohol consumption...
February 12, 2018: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29429159/-retroperitoneal-dedifferentiated-liposarcoma-with-rhabdomyoblastic-differentiation-a-clinicopathological-analysis
#16
L Liu, L H Wang, Y B Ren, X S Rao, S M Yang
Objective: To investigate the clinicopathological features, differential diagnosis, treatment and prognosis of dedifferentiated liposarcoma with rhabdomyoblastic differentiation. Methods: Six cases of retroperitoneal dedifferentiated liposarcoma with rhabdomyoblastic features were collected from December 2014 to August 2017 at Peking University International Hospital. The clinical manifestations, histomorphology, immunophenotype, treatment and follow-up data were analyzed, and relevant literature reviewed. Results: The six patients included two males and four females, with age range of 47 to 66 years (mean 56 years)...
February 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29427237/differential-expression-of-lp-pla2-in-obesity-and-type-2-diabetes-and-the-influence-of-lipids
#17
Laura Jackisch, Warunee Kumsaiyai, Jonathan D Moore, Nasser Al-Daghri, Ioannis Kyrou, Thomas M Barber, Harpal Randeva, Sudhesh Kumar, Gyanendra Tripathi, Philip G McTernan
AIMS/HYPOTHESIS: Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a circulatory macrophage-derived factor that increases with obesity and leads to a higher risk of cardiovascular disease (CVD). Despite this, its role in adipose tissue and the adipocyte is unknown. Therefore, the aims of this study were to clarify the expression of Lp-PLA2 in relation to different adipose tissue depots and type 2 diabetes, and ascertain whether markers of obesity and type 2 diabetes correlate with circulating Lp-PLA2...
February 9, 2018: Diabetologia
https://www.readbyqxmd.com/read/29426925/ageing-potentiates-diet-induced-glucose-intolerance-%C3%AE-cell-failure-and-tissue-inflammation-through-tlr4
#18
Wei He, Ting Yuan, Dolma Choezom, Hannah Hunkler, Karthika Annamalai, Blaz Lupse, Kathrin Maedler
Ageing and obesity are two major risk factors for the development of type 2 diabetes (T2D). A chronic, low-grade, sterile inflammation contributes to insulin resistance and β-cell failure. Toll-like receptor-4 (TLR4) is a major pro-inflammatory pathway; its ligands as well as downstream signals are increased systemically in patients with T2D and at-risk individuals. In the present study we investigated the combined effects of high fat/high sucrose diet (HFD) feeding, ageing and TLR4-deficiency on tissue inflammation, insulin resistance and β-cell failure...
February 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29425818/dna-methylation-of-the-klf14-gene-region-on-whole-blood-provide-prediction-for-the-chronic-inflammation-at-the-adipose-tissue
#19
Chihiro Iwaya, Hidetoshi Kitajima, Ken Yamamoto, Yasutaka Maeda, Noriyuki Sonoda, Hiroki Shibata, Toyoshi Inoguchi
Krüppel-Like Factor 14 (KLF14) gene, which appears to be a master regulator of gene expression on the adipose tissue and have previously been associated with BMI and Type 2 diabetes (T2D) by large GWAS studies. In order to find predictive biomarkers for the development of T2D, it is necessary to take into account changes in the epigenome affected by environmental factors. This study focused on aging and obesity, which are T2D risk factor, and examines epigenetic changes and inflammatory changes. Thus we investigated DNA methylation change at Klf14 promoter region of different organs using mice for comparing aging and weight...
February 6, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29417316/body-mass-index-abdominal-fatness-and-the-risk-of-sudden-cardiac-death-a-systematic-review-and-dose-response-meta-analysis-of-prospective-studies
#20
Dagfinn Aune, Sabrina Schlesinger, Teresa Norat, Elio Riboli
Although overweight and obesity are established risk factors for some types of heart disease including ischemic heart disease, heart failure and atrial fibrillation, less is known about the association between adiposity and sudden cardiac death. We conducted a systematic review and meta-analysis of prospective studies to clarify the association between adiposity and risk of sudden cardiac death. PubMed and Embase databases were searched up to July 20th 2017. Summary relative risks (RRs) and 95% confidence intervals (CIs) were calculated using random effects models...
February 7, 2018: European Journal of Epidemiology
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