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https://www.readbyqxmd.com/read/29932432/serum-levels-of-angiopoietin-like-protein-2-and-obestatin-in-iranian-women-with-polycystic-ovary-syndrome-and-normal-body-mass-index
#1
Elham Rahmani, Samad Akbarzadeh, Ainaz Broomand, Fatemeh Torabi, Niloofar Motamed, Marzieh Zohrabi
BACKGROUND: Polycystic ovary syndrome (PCOS) is a common endocrine disease in women of reproduction age and a major cause of anovulatory infertility. Insulin resistance plays an important role in the development and durability of this disorder. ANGPTL2 is known as an inflammatory mediator derived from adipose tissue that links obesity to systemic insulin resistance, and obestatin has been identified as a hormone associated with insulin resistance that suppresses food reabsorption, inhibits gastric emptying and decreases weight gain...
June 22, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29931812/postprandial-triglycerides-predict-newborn-fat-more-strongly-than-glucose-in-women-with-obesity-in-early-pregnancy
#2
Linda A Barbour, Sarah S Farabi, Jacob E Friedman, Nicole M Hirsch, Melanie S Reece, Rachael E Van Pelt, Teri L Hernandez
OBJECTIVE: Maternal obesity (OB) accounts for the majority of large-for-gestational-age infants, and newborn percent fat (NB%fat) correlates strongest with childhood OB. In addition to maternal glucose, fasting triglycerides (TGs) may contribute, but postprandial triglycerides (PPTGs) are unstudied. It was hypothesized that fasting TGs and PPTGs are higher in women with OB compared with women with normal weight (NW) throughout pregnancy, correlate more strongly with NB%fat than glucose, and may relate to dietary chylomicron TGs...
June 22, 2018: Obesity
https://www.readbyqxmd.com/read/29931237/adipogenic-lipogenic-gene-expression-and-fatty-acid-composition-in-chuck-loin-and-round-muscles-in-response-to-grain-feeding-of-yanbian-yellow-cattle
#3
Xiang Z Li, C G Yan, Qi S Gao, Y Yan, Seong H Choi, Stephen B Smith
We hypothesized that gene expression and fatty acid composition would differ among different muscle depots and over time on a grain-based finishing diet. Additionally, we hypothesized that the concentration of SFA would decrease and the concentration of MUFA would increase proportionately with increases in percent intramuscular lipid (%IML). Ten Yanbian Yellow cattle steers (approximately 8 mo of age) were fed a corn-based diet in which the proportion of corn in the ration was increased at 4-mo intervals. Muscle samples were taken by biopsy from the chuck (trapezius), loin (longissimus dorsi), and round (biceps femoris) muscles at 12, 16, 20, 24, and 28 mo of age...
June 21, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29931120/association-of-body-mass-index-and-age-with-subsequent-breast-cancer-risk-in-premenopausal-women
#4
Minouk J Schoemaker, Hazel B Nichols, Lauren B Wright, Mark N Brook, Michael E Jones, Katie M O'Brien, Hans-Olov Adami, Laura Baglietto, Leslie Bernstein, Kimberly A Bertrand, Marie-Christine Boutron-Ruault, Tonje Braaten, Yu Chen, Avonne E Connor, Miren Dorronsoro, Laure Dossus, A Heather Eliassen, Graham G Giles, Susan E Hankinson, Rudolf Kaaks, Timothy J Key, Victoria A Kirsh, Cari M Kitahara, Woon-Puay Koh, Susanna C Larsson, Martha S Linet, Huiyan Ma, Giovanna Masala, Melissa A Merritt, Roger L Milne, Kim Overvad, Kotaro Ozasa, Julie R Palmer, Petra H Peeters, Elio Riboli, Thomas E Rohan, Atsuko Sadakane, Malin Sund, Rulla M Tamimi, Antonia Trichopoulou, Giske Ursin, Lars Vatten, Kala Visvanathan, Elisabete Weiderpass, Walter C Willett, Alicja Wolk, Jian-Min Yuan, Anne Zeleniuch-Jacquotte, Dale P Sandler, Anthony J Swerdlow
Importance: The association between increasing body mass index (BMI; calculated as weight in kilograms divided by height in meters squared) and risk of breast cancer is unique in cancer epidemiology in that a crossover effect exists, with risk reduction before and risk increase after menopause. The inverse association with premenopausal breast cancer risk is poorly characterized but might be important in the understanding of breast cancer causation. Objective: To investigate the association of BMI with premenopausal breast cancer risk, in particular by age at BMI, attained age, risk factors for breast cancer, and tumor characteristics...
June 21, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29929204/sport-participation-and-metabolic-risk-during-adolescent-years-a-structured-equation-model
#5
AndréOliveira Werneck, Danilo Rodrigues Pereira da Silva, Rômulo Araújo Fernandes, EnioRicardoVaz Ronque, Manuel J Coelho-E-Silva, Edilson Serpeloni Cyrino
Sports practice during childhood can influence health indicators in later ages through direct and indirect pathways. Thus, this study aimed to test direct and indirect pathways to the association between sports practice in childhood and metabolic risk in adolescence, adopting physical activity, adiposity, and cardiorespiratory fitness at adolescence as potential mediators. This cross-sectional study with retrospective information was conducted with 991 adolescents (579 girls, 412 boys) aged 10 to 16 y. Sports activity was self-reported in childhood (retrospective data) and physical activity evaluated in adolescence through questionnaires...
June 21, 2018: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29928260/liver-enlargement-predicts-obstructive-sleep-apnea-hypopnea-syndrome-in-morbidly-obese-women
#6
Giovanna Scartabelli, Giorgia Querci, Letizia Marconi, Giovanni Ceccarini, Paolo Piaggi, Paola Fierabracci, Guido Salvetti, Giovanni Cizza, Salvatore Mazzeo, Jacopo Vitti, Slava Berger, Antonio Palla, Ferruccio Santini
Obstructive sleep apnea-hypopnea syndrome (OSAHS) is frequently present in patients with severe obesity, but its prevalence especially in women is not well defined. OSAHS and non-alcoholic fatty liver disease are common conditions, frequently associated in patients with central obesity and metabolic syndrome and are both the result of the accumulation of ectopic fat mass. Identifying predictors of risk of OSAHS may be useful to select the subjects requiring instrumental sleep evaluation. In this cross-sectional study, we have investigated the potential role of hepatic left lobe volume (HLLV) in predicting the presence of OSAHS...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29928203/nevus-lipomatosis-cutaneous-superficialis-a-single-center-case-series-of-5-patients
#7
Homaid Alotaibi, Fahad Alsaif, Azhar Alali, Mohammed Almashali, Dana Al-Dabeeb, Abdul-Aziz Altaweel
Background: Nevus lipomatosis cutaneous superficialis (NLCS) is a rare hamartoma of mature adipose tissue characterized by solitary or multiple, soft, skin-colored or yellowish lobules that may coalesce to give rise to plaques with a cerebriform surface. There are two clinical types: (1) multiple lesions that are usually presented in a segmental distribution and (2) a solitary papule or nodule. Aim and Objective: To study the clinical and histopathological features of 5 Saudi patients with NLCS...
May 2018: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29927819/a-longitudinal-study-of-road-traffic-noise-and-body-mass-index-trajectories-from-birth-to-8-years
#8
Kjell Vegard Weyde, Norun Hjertager Krog, Bente Oftedal, Per Magnus, Richard White, Stephen Stansfeld, Simon Øverland, Gunn Marit Aasvang
BACKGROUND: Being overweight constitutes a health risk, and the proportion of overweight and obese children is increasing. It has been argued that road traffic noise could be linked to adiposity through its influence on sleep and stress. Few studies, to our knowledge, have investigated whether noise and adiposity are associated. Most of them were on adults, and we are not aware of any longitudinal study using repeated measures. OBJECTIVES: The present longitudinal study investigated whether road traffic noise exposures in pregnancy (N=6,963; obs=22,975) or childhood (N=6,403; obs=14,585) were associated with body mass index (BMI) trajectories in children...
June 20, 2018: Epidemiology
https://www.readbyqxmd.com/read/29925515/change-in-inflammatory-biomarkers-and-adipose-tissue-in-brca1-2-breast-cancer-survivors-following-a-year-long-lifestyle-modification-program
#9
Kathleen M Sturgeon, Wayne Y Foo, Mariane L Heroux, Kathryn Schmitz
Breast cancer survivors who carry a genetic mutation for one of the BRCA genes often undergo surgically-induced menopause a decade or more before the usual age of natural menopause. These women are at elevated risk for multiple negative health outcomes, including metabolic diseases, heart disease, and cancer recurrence. Effects of a 12-month commercially available web-based lifestyle program (Precision Nutrition) were tested on body composition and markers of inflammation in a randomized controlled trial. Participants (N=35) were BRCA1/2+, breast cancer survivors, and had completed surgically-induced menopause at age <45 years...
June 20, 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/29924824/effect-of-adiposity-on-tissue-specific-adiponectin-secretion
#10
James Reneau, Matthew Goldblatt, Jon Gould, Tammy Kindel, Andrew Kastenmeier, Rana Higgins, L Rosemary Rengel, Katherine Schoyer, Roland James, Brittaney Obi, Andrea Moosreiner, Kay Nicholson, Daisy Sahoo, Srividya Kidambi
Circulating adiponectin levels are lower in individuals with increased BMI and central adiposity. However, they are paradoxically higher in those with peripheral adiposity. We hypothesized that adiponectin secretion from central and peripheral adipose tissue depots may be associated with adiposity levels and its distribution. A total of 55 subjects (69% women) undergoing elective abdominal surgery (mean age: 53 ± 13 years) were recruited. Health history, anthropometrics, and cardiovascular disease risk factor measurements were obtained...
2018: PloS One
https://www.readbyqxmd.com/read/29924321/relative-weight-gain-through-age-4-years-is-associated-with-increased-adiposity-and-higher-blood-pressure-and-insulinemia-at-4-5-years-of-age-in-mexican-children
#11
Ivonne Ramirez-Silva, Juan A Rivera, Belem Trejo-Valdivia, Aryeh D Stein, Reynaldo Martorell, Isabelle Romieu, Albino Barraza-Villarreal, Laura Avila-Jiménez, Usha Ramakrishnan
Background: Rapid early weight gain has been associated with increased risk of obesity and cardiometabolic alterations, but evidence in low and middle-income countries is inconclusive. Objective: We evaluated the relation between relative weight gain from 1 to 48 mo with adiposity and cardiometabolic risk factors at 4-5 y of age, and determined if adiposity is a mediator for cardiometabolic alterations. Methods: We studied 428 Mexican children with anthropometric and blood pressure (BP) information from birth to 5 y of age from POSGRAD (Prenatal Omega-3 fatty acid Supplementation and child GRowth And Development), of whom 334 provided measures of adiposity and cardiometabolic risk markers at 4 y...
June 19, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29923341/organochlorine-pesticide-residues-in-human-breast-tissue-and-their-relationships-with-clinical-and-pathological-characteristics-of-breast-cancer
#12
Rachel E Ellsworth, Paul J Kostyniak, Lai-Har Chi, Craig D Shriver, Nicholas S Costantino, Darrell L Ellsworth
Agricultural pesticides are abundant environmental contaminants worldwide, prompting interest in studying their possible detrimental health effects. We examined organochlorine residues by quadrant (n = 245) in breast adipose tissues from 51 women with various stages of breast health to determine patterns of bioaccumulation within the breast and to assess relationships with patient clinical characteristics. Three organochlorine residues-2,2-bis(p-chlorophenyl)-1,1-dichloroethylene (p,p'-DDE), hexachlorobenzene (HCB), and mirex-assayed by high resolution gas chromatography were abundant in breast tissue...
June 19, 2018: Environmental Toxicology
https://www.readbyqxmd.com/read/29923193/high-folate-intake-contributes-to-the-risk-of-large-for-gestational-age-birth-and-obesity-in-male-offspring
#13
Kaipeng Xie, Ziyi Fu, Hui Li, Xiaohong Gu, Zhiyong Cai, Pengfei Xu, Xianwei Cui, Lianghui You, Xing Wang, Lijun Zhu, Chenbo Ji, Xirong Guo
Folate supplementation is recommended before and during early pregnancy to prevent neural tube defects, but the effect of red blood cell (RBC) folate on large for gestational age (LGA) is still unknown. We performed a nested case-control study including 542 LGA cases and 1,084 appropriate for gestational age (AGA) controls to examine the association of RBC folate concentrations with risk of LGA. Then, male offspring of dams fed basic folic acid (2 mg/kg, control) or 10-fold folic acid (20 mg/kg, HFol) diet before and during pregnancy were used to explore the effect of high folate intake on birth weight and long-term effects...
June 19, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29923191/effects-of-endurance-exercise-training-on-inflammatory-circulating-progenitor-cell-content-in-lean-and-obese-adults
#14
Grace M Niemiro, Jacob M Allen, Lucy J Mailing, Naiman A Khan, Hannah D Holscher, Jeffrey A Woods, Michael De Lisio
KEY POINTS: Chronic inflammation underlies many of the health decrements associated with obesity. Circulating progenitor cells can sense and respond to inflammatory stimuli, increasing the local inflammatory response within tissues. Here we show that 6 weeks of endurance exercise training significantly decreases inflammatory circulating progenitor cells in obese adults. These findings provide novel cellular mechanisms for the beneficial effects of exercise in obese adults. ABSTRACT: Circulating progenitor cells (CPCs) and subpopulations are normally found in the bone marrow, but can migrate to peripheral tissues to participate in local inflammation and/or remodelling...
June 19, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29921325/inhibition-of-the-rhogtpase-cdc42-by-ml141-enhances-hepatocyte-differentiation-from-human-adipose-derived-mesenchymal-stem-cells-via-the-wnt5a-pi3k-mir-122-pathway-impact-of-the-age-of-the-donor
#15
Diana Chaker, Charbel Mouawad, Albert Azar, Didier Quilliot, Ibrahim Achkar, Ziad Fajloun, Nehman Makdissy
BACKGROUND: Human adipose-derived mesenchymal stem cells (hADSCs) are promising cells that may promote hepatocyte differentiation (Hep-Dif) and improve liver function, but the involvement of Cdc42, a key small RhoGTPase which plays a crucial role in aging, is still not well established. We hypothesized that the inhibition of Cdc42 may rescue the hepatogenic potential of hADSCs derived from aged donors. METHODS: hADSCs isolated from 61 women of different ages were cultured for evaluation of the proliferation of cells, adherence, apoptosis, immunomodulation, immunophenotyping, multipotency, gene expression, and cell function during Hep-Dif...
June 19, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29921311/adipose-derived-and-bone-marrow-mesenchymal-stem-cells-a-donor-matched-comparison
#16
Samih Mohamed-Ahmed, Inge Fristad, Stein Atle Lie, Salwa Suliman, Kamal Mustafa, Hallvard Vindenes, Shaza B Idris
BACKGROUND: Adipose-derived stem cells (ASCs) have been introduced as an alternative to bone marrow mesenchymal stem cells (BMSCs) for cell-based therapy. However, different studies comparing ASCs and BMSCs have shown conflicting results. In fact, harvesting ASCs and BMSCs from different individuals might influence the results, making comparison difficult. Therefore, this study aimed to characterize donor-matched ASCs and BMSCs in order to investigate proliferation, differentiation potential and possible effects of donor variation on these mesenchymal stem cells (MSCs)...
June 19, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29920529/assessment-of-the-awareness-and-knowledge-of-cancer-survivors-regarding-the-components-of-metabolic-syndrome
#17
Yeji Seo, Ji-Su Kim, Eun-Shim Park, Eunjung Ryu
This study aimed to assess the prevalence of metabolic syndrome and the level of knowledge and awareness of its related conditions in a sample of cancer survivor patients. In this cross-sectional survey, a self-reported questionnaire was administered to outpatients aged >20 years with a diagnosis of cancer. This self-reported questionnaire on patient demographic characteristics, disease characteristics, and knowledge and awareness of metabolic syndrome was used as an instrument to assess patient's knowledge of metabolic syndrome...
2018: PloS One
https://www.readbyqxmd.com/read/29917037/high-plasma-apolipoprotein-b-identifies-obese-subjects-who-best-ameliorate-white-adipose-tissue-dysfunction-and-glucose-induced-hyperinsulinemia-after-a-hypocaloric-diet
#18
Simon Bissonnette, Nathalie Saint-Pierre, Valerie Lamantia, Catherine Leroux, Viviane Provost, Yannick Cyr, Remi Rabasa-Lhoret, May Faraj
Background: To optimize the prevention of type 2 diabetes (T2D), high-risk obese subjects with the best metabolic recovery after a hypocaloric diet should be targeted. Apolipoprotein B lipoproteins (apoB lipoproteins) induce white adipose tissue (WAT) dysfunction, which in turn promotes postprandial hypertriglyceridemia, insulin resistance (IR), and hyperinsulinemia. Objective: The aim of this study was to explore whether high plasma apoB, or number of plasma apoB lipoproteins, identifies subjects who best ameliorate WAT dysfunction and related risk factors after a hypocaloric diet...
June 18, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29916894/modified-treatment-algorithm-for-pseudogynecomastia-after-massive-weight-loss
#19
Ulrich E Ziegler, Udo Lorenz, Adrien Daigeler, Selina N Ziegler, Philip H Zeplin
BACKGROUND: Pseudogynecomastia is the increased aggregation of fatty tissue in the area of the male breast with resultant female appearance. Two forms can appear: pseudogynecomastia after massive weight loss (pseudogynecomastia obese [PO]) and pseudogynecomastia, which is caused only by adipose tissue (pseudogynecomastia fat). For PO, only the Gusenoff classification with corresponding operative treatment options exists. However, this classification is limited by the fact that it underestimates the extensive variability of residual fat tissue and skin excess, both crucial factors for operative planning...
June 19, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29915252/the-impact-of-dxa-derived-fat-free-adipose-tissue-on-the-prevalence-of-low-muscle-mass-in-older-adults
#20
Takashi Abe, Jeremy P Loenneke, Robert S Thiebaud, Eiji Fujita, Takuya Akamine
BACKGROUND/OBJECTIVES: To investigate the impact of eliminating fat-free adipose tissue (aFFAT) on the prevalence of low muscle mass in older adults. SUBJECTS/METHODS: Three hundred and forty-three (153 men and 190 women) well-functioning Japanese older adults (aged 65-79) had their appendicular lean mass (aLM) and appendicular fat mass (aFM) measured using dual-energy X-ray absorptiometry (DXA). aFFAT was then estimated from DXA-derived aFM (aFM = (FM/0.15)*0...
June 18, 2018: European Journal of Clinical Nutrition
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