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Neuromyelitis

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https://www.readbyqxmd.com/read/29775851/comparative-study-of-quality-of-life-anxiety-depression-and-fatigue-among-patients-with-neuromyelitis-optica-spectrum-disorder-and-multiple-sclerosis-the-first-report-from-iran
#1
Mahdi Barzegar, Shervin Badihian, Omid Mirmosayyeb, Fereshteh Ashtari, Maryam Jamadi, Shohreh Emami, Leila Jahani, Armaghan Safavi, Vahid Shaygannejad
BACKGROUND: Neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) are associated with reduced Health Related Quality of Life (HRQOL). To the best of our knowledge, change of HRQOL in patients with NMOSD has not been yet measure in Iran. The objective of this study was to assess HRQOL in NMOSD and MS patients and identify related factors METHODS: A cross sectional study of 41 patients with NMOSD and 136 age and sex-match MS patients was performed. A series of questionnaires including Persian validated questionnaires on HRQOL (SF-36), fatigue (MFIS), depression (BDI-II), anxiety (HAM-A) and sleep quality (PSQI) were record...
April 14, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29771191/pure-spinal-multiple-sclerosis-a-possible-novel-entity-within-the-multiple-sclerosis-disease-spectrum
#2
Jie Ping Schee, Shanthi Viswanathan
We identified five female patients retrospectively with relapsing short-segment partial myelitis whose clinical and paraclinical features were suggestive of cord involvement of multiple sclerosis (MS)-type albeit not rigidly fulfilling the 2017 McDonald criteria. Notably, these patients had not developed any typical MS-like brain lesions despite repeated neuroimaging assessments over years. Comprehensive work-up for differential diagnoses of MS and other causes of transverse myelitis particularly neuromyelitis optica spectrum disorders had been consistently negative on longitudinal follow-up...
May 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29771186/cross-modal-plasticity-among-sensory-networks-in-neuromyelitis-optica-spectrum-disorders
#3
Maria Assunta Rocca, Filippo Savoldi, Paola Valsasina, Marta Radaelli, Paolo Preziosa, Giancarlo Comi, Andrea Falini, Massimo Filippi
OBJECTIVE: To explore resting-state (RS) functional connectivity (FC) of the main sensory/motor networks of patients with neuromyelitis optica spectrum disorders (NMOSDs), clinically isolated optic neuritis (ON), and myelitis. METHODS: Clinical evaluation and RS fMRI were obtained from 28 NMOSD, 11 recurrent ON, and 12 recurrent myelitis patients and 30 healthy controls. Between-group RS FC comparisons and correlations with motor performance were assessed (SPM12) on the main sensory/motor RS networks (RSNs) identified by independent component analysis...
May 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29769526/a-whole-genome-sequence-study-identifies-genetic-risk-factors-for-neuromyelitis-optica
#4
Karol Estrada, Christopher W Whelan, Fengmei Zhao, Paola Bronson, Robert E Handsaker, Chao Sun, John P Carulli, Tim Harris, Richard M Ransohoff, Steven A McCarroll, Aaron G Day-Williams, Benjamin M Greenberg, Daniel G MacArthur
Neuromyelitis optica (NMO) is a rare autoimmune disease that affects the optic nerve and spinal cord. Most NMO patients ( > 70%) are seropositive for circulating autoantibodies against aquaporin 4 (NMO-IgG+). Here, we meta-analyze whole-genome sequences from 86 NMO cases and 460 controls with genome-wide SNP array from 129 NMO cases and 784 controls to test for association with SNPs and copy number variation (total N = 215 NMO cases, 1244 controls). We identify two independent signals in the major histocompatibility complex (MHC) region associated with NMO-IgG+, one of which may be explained by structural variation in the complement component 4 genes...
May 16, 2018: Nature Communications
https://www.readbyqxmd.com/read/29766684/neuromyelitis-optica-review-and-utility-of-testing-aquaporin-4-antibody-in-typical-optic-neuritis
#5
Meagan Seay, Janet C Rucker
Neuromyelitis optica (NMO) is an autoimmune, inflammatory demyelinating disorder often leading to severe vision impairment and disability. The discovery of a diagnostic biomarker, the aquaporin-4 antibody (AQP4-IgG), transformed the clinical diagnosis and treatment of NMO and broadened the spectrum of disease [NMO spectrum disorders (NMOSD)]. Though the antibody is highly sensitive and specific to NMOSD, routine testing in patients with typical optic neuritis is considered controversial. This article will provide a brief review of NMOSD and highlight the pros and cons of routine testing in typical optic neuritis...
May 16, 2018: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/29761736/treating-neuromyelitis-optica-with-azathioprine-20-year-clinical-practice
#6
Denis Bernardi Bichuetti, Marília Mamprim de Moraes Perin, Nilton Amorim de Souza, Enedina Maria Lobato de Oliveira
BACKGROUND: Neuromyelitis optica leads to severe disability. Preventive treatment includes steroids and immunosuppressants, and indications are based on retrospective and observational studies. METHODS: We analyzed 158 patients with neuromyelitis optica regarding disease course, prognostic factors, and treatment response to azathioprine, a widely available low-cost drug. Disability accumulation was used as an endpoint to treatment response. RESULTS: Eight patients with monophasic and 150 with relapsing disease with a median 7 years of disease duration and 4...
May 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29752554/secondary-hypogammaglobulinemia-after-rituximab-for-neuromyelitis-optica-a-case-report
#7
Lara Farhat, Jasmeen Dara, Susan Duberstein, Aliva De
A 17-year-old male with history of neuromyelitis optica and seizures presented to the pulmonology clinic for evaluation of recurrent pneumonias. He had received rituximab for the past 6 years. Over the past 2 years, he experienced four episodes of pneumonia. In between these episodes, he would improve briefly but continued to have daily cough that was productive with yellow phlegm. He also had recurrent rhinitis and sinusitis despite multiple antibiotic courses. Review of chest X-rays revealed localized right middle lobe and right lower lobe infiltrates...
May 11, 2018: Drug Safety—Case Reports
https://www.readbyqxmd.com/read/29750948/altered-macular-microvasculature-in-neuromyelitis-optica-spectrum-disorders
#8
William Robert Kwapong, Chenlei Peng, Zhiyong He, Xiran Zhuang, Meixiao Shen, Fan Lu
PURPOSE: To evaluate macular microvascular changes in neuromyelitis optica spectrum disorders (NMOSD) by using optical coherence tomography angiography (OCT-A) and investigate their correlations with neuroaxonal structural damage evaluated with Spectral domain OCT (SD-OCT). DESIGN: Cross-sectional study. METHODS: Twenty eyes of 20 patients with NMOSD and 21 eyes from 21 healthy controls were enrolled. OCT-A was used to obtain microvascular network images of the whole, superficial, and deep retinal capillary plexuses (WRCP, SRCP, and DRCP) in a 3-mm diameter area around the macula...
May 8, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29748202/mri-based-methods-for-spinal-cord-atrophy-evaluation-a-comparison-of-cervical-cord-cross-sectional-area-cervical-cord-volume-and-full-spinal-cord-volume-in-patients-with-aquaporin-4-antibody-seropositive-neuromyelitis-optica-spectrum-disorders
#9
C Chien, A U Brandt, F Schmidt, J Bellmann-Strobl, K Ruprecht, F Paul, M Scheel
BACKGROUND AND PURPOSE: Measures for spinal cord atrophy have become increasingly important as imaging biomarkers in the assessment of neuroinflammatory diseases, especially in neuromyelitis optica spectrum disorders. The most commonly used method, mean upper cervical cord area, is relatively easy to measure and can be performed on brain MRIs that capture cervical myelon. Measures of spinal cord volume (eg, cervical cord volume or total cord volume) require longer scanning and more complex analysis but are potentially better suited as spinal cord atrophy measures...
May 10, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29747362/-research-progression-of-animal-models-of-idiopathic-optic-neuritis
#10
Y X Zhang, H Yang
Idiopathic optic neuritis (ON) is an idiopathic inflammatory disease of the optic nerve. The two most common types of ON are multiple sclerosis related ON and neuromyelitis optica related ON. But so far the precise mechanisms of different types of ON have been unclear and treatments are not satisfactory. Animal disease models play critical roles in the disease mechanism research. On the other hand, with more understanding about the etiology and mechanism of ON, new models mimicking different types of ON are under development...
April 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29747309/-etiological-analysis-on-patients-with-vertigo-or-dizziness
#11
H Xue, Y Chong, Z D Jiang, Z L Liu, L Ding, S L Yang, L Wang, W P Xiang
Objective: To explore the spectrum of causes for patients with vertigo or dizziness in the Department of Neurology, and provide a reference for diagnosis and treatment of patients with vertigo or dizziness. Methods: Clinical data of patients in the Department of Neurology, Baotou Central Hospital between January 2016 and September 2017 was retrospectively analyzed. The target group under study was diagnosed based on the uniform diagnostic criteria. Results: A total of 9 200 patients with a chief complaint of vertigo or dizziness were included...
April 24, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29724765/imaging-differences-between-neuromyelitis-optica-spectrum-disorders-and-multiple-sclerosis-a-multi-institutional-study-in-japan
#12
H Tatekawa, S Sakamoto, M Hori, Y Kaichi, A Kunimatsu, K Akazawa, T Miyasaka, H Oba, T Okubo, K Hasuo, K Yamada, T Taoka, S Doishita, T Shimono, Y Miki
BACKGROUND AND PURPOSE: Both clinical and imaging criteria must be met to diagnose neuromyelitis optica spectrum disorders and multiple sclerosis. However, neuromyelitis optica spectrum disorders are often misdiagnosed as MS because of an overlap in MR imaging features. The purpose of this study was to confirm imaging differences between neuromyelitis optica spectrum disorders and MS with visually detailed quantitative analyses of large-sample data. MATERIALS AND METHODS: We retrospectively examined 89 consecutive patients with neuromyelitis optica spectrum disorders (median age, 51 years; range, 16-85 years; females, 77; aquaporin 4 immunoglobulin G-positive, 93%) and 89 with MS (median age, 36 years; range, 18-67 years; females, 68; relapsing-remitting MS, 89%; primary-progressive MS, 7%; secondary-progressive MS, 2%) from 9 institutions across Japan (April 2008 to December 2012)...
May 3, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29724224/mog-encephalomyelitis-international-recommendations-on-diagnosis-and-antibody-testing
#13
REVIEW
S Jarius, F Paul, O Aktas, N Asgari, R C Dale, J de Seze, D Franciotta, K Fujihara, A Jacob, H J Kim, I Kleiter, T Kümpfel, M Levy, J Palace, K Ruprecht, A Saiz, C Trebst, B G Weinshenker, B Wildemann
Over the past few years, new-generation cell-based assays have demonstrated a robust association of autoantibodies to full-length human myelin oligodendrocyte glycoprotein (MOG-IgG) with (mostly recurrent) optic neuritis, myelitis and brainstem encephalitis, as well as with acute disseminated encephalomyelitis (ADEM)-like presentations. Most experts now consider MOG-IgG-associated encephalomyelitis (MOG-EM) a disease entity in its own right, immunopathogenetically distinct from both classic multiple sclerosis (MS) and aquaporin-4 (AQP4)-IgG-positive neuromyelitis optica spectrum disorders (NMOSD)...
May 3, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29722742/neuromyelitis-optica-and-herpes-simplex-virus-2-a-viral-trigger-for-aquaporin-4-autoimmunity
#14
I Vanessa Marin Collazo, Charles L Howe, Claudia F Lucchinetti, W Oliver Tobin
The clinical and radiographic spectrum of Neuromyelitis optica spectrum disorder has broadened following the description of the aquaporin-4 antibody. The initial triggering event and reason for disease quiescence between relapses is unclear. We present a case of myeloradiculitis associated with aquaporin-4 antibody and concomitant herpes simplex virus 2 infection.
May 2018: Neurologist
https://www.readbyqxmd.com/read/29722193/hypothalamic-demyelination-causing-panhypopituitarism
#15
Julia Dixon-Douglas, John Burgess, Michael Dreyer
Hypothalamic involvement in multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) is rare and endocrinopathies involving the hypothalamic-pituitary axis in patients with demyelinating conditions have rarely been reported. We present two cases of MS/NMOSD with associated hypothalamic-pituitary involvement and subsequent hypopituitarism, including the first report of a patient with hypothalamic demyelination causing panhypopituitarism. Differential diagnoses, including alemtuzumab-related and primary pituitary pathology are discussed...
May 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29721683/pediatric-neuromyelitis-optica-spectrum-disorders
#16
REVIEW
Grace Y Gombolay, Tanuja Chitnis
PURPOSE OF REVIEW: Neuromyelitis optica spectrum disorders (NMOSDs) are a group of inflammatory and demyelinating disorders of the central nervous system that can occur in children and adults. The classic presentation of NMOSD is characterized by optic neuritis and transverse myelitis, but other presentations are also recognized, expanding the disease as NMO spectrum disorders. The purpose of this review is to discuss the clinical features, along with management and treatment options, including potential future therapeutic options, in pediatric NMOSD...
May 2, 2018: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/29716388/alice-in-wonderland-syndrome-secondary-to-optical-neuromyelitis-caused-by-varicella
#17
Alisson Paulino Trevizol, Raphael Cerqueira, Elisa Brietzke, Quirino Cordeiro
No abstract text is available yet for this article.
April 1, 2018: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/29709797/trident-sign-trumps-aquaporin-4-igg-elisa-in-diagnostic-value-in-a-case-of-longitudinally-extensive-transverse-myelitis
#18
Evan A Jolliffe, B Mark Keegan, Eoin P Flanagan
Longitudinally-extensive T2-hyperintense spinal cord lesions (≥3 vertebral segments) are associated with neuromyelitis optical spectrum disorder but occur with other disorders including spinal cord sarcoidosis. When linear dorsal subpial enhancement is accompanied by central cord/canal enhancement the axial post-gadolinium sequences may reveal a "trident" pattern that has previously been shown to be strongly suggestive of spinal cord sarcoidosis. We report a case in which the patient was initially diagnosed with neuromyelitis optical spectrum disorder, but where the "trident" sign ultimately led to the correct diagnosis of spinal cord sarcoidosis...
April 21, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29703264/cerebrospinal-fluid-mitochondrial-dna-in-neuromyelitis-optica-spectrum-disorder
#19
Kazuya Yamashita, Makoto Kinoshita, Katsuichi Miyamoto, Akiko Namba, Mikito Shimizu, Toru Koda, Tomoyuki Sugimoto, Yuki Mori, Yoshichika Yoshioka, Yuji Nakatsuji, Atsushi Kumanogoh, Susumu Kusunoki, Hideki Mochizuki, Tatsusada Okuno
BACKGROUND: Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory disease of the central nervous system. Although complement-dependent astrocyte damage mediated by anti-aquaporin 4 autoantibody (AQP4-Ab) is well acknowledged to be the core of NMOSD pathogenesis, additional inflammatory cascades may contribute to the establishment of lesion formation. Thus, in this study, we investigated the possible pathogenic role of immune-reactive mitochondrial DNA (mtDNA) in cerebrospinal fluid (CSF) of NMOSD patients...
April 27, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29695599/time-to-separate-mog-ab-associated-disease-from-aqp4-ab-positive-neuromyelitis-optica-spectrum-disorder
#20
EDITORIAL
Yael Hacohen, Jacqueline Palace
No abstract text is available yet for this article.
April 25, 2018: Neurology
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