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https://www.readbyqxmd.com/read/28632021/neuromyelitis-optica-application-of-computer-diagnostics-to-historical-case-reports
#1
Pablo Garcia Reitboeck, Peter Garrard, Timothy Peters
The retrospective diagnosis of illnesses by medical historians can often be difficult and prone to bias, although knowledge of the medical disorders of historical figures is key to the understanding of their behavior and reactions. The recent application of computer diagnostics to historical figures allows an objective differential diagnosis to be accomplished. Taking an example from clinical neurology, we analyzed the earliest reported cases of Devic's disease (neuromyelitis optica) that commonly affects the optic nerve and spinal cord and was previously often confused with multiple sclerosis...
February 10, 2017: Journal of the History of the Neurosciences
https://www.readbyqxmd.com/read/28626410/neuromyelitis-optica-spectrum-disorder-coinciding-with-spinocerebellar-ataxia-type-31
#2
Yoshiaki Takahashi, Yasuhiro Manabe, Ryuta Morihara, Hisashi Narai, Toru Yamashita, Koji Abe
We report the unusual case of a 63-year-old man with spinocerebellar ataxia (SCA) type 31 who developed neuromyelitis optica spectrum disorder (NMOSD) 14 years after the onset of cerebellar symptoms. In addition to cerebellar atrophy, magnetic resonance imaging showed multiple high-intensity areas in the brain and a long thoracic cord lesion from Th1/2 to Th11. The combination of NMOSD and SCA31 is accidental. However, our case suggests that inflammatory processes could be involved in the pathogenesis of NMOSD and SCA31...
May 2017: Case Reports in Neurology
https://www.readbyqxmd.com/read/28622910/the-link-between-morphology-and-complement-in-ocular-disease
#3
Camilla Mohlin, Kerstin Sandholm, Kristina N Ekdahl, Bo Nilsson
The complement system is a vital component of the immune-priveliged human eye that is always active at a low-grade level, preventing harmful intraocular injuries caused by accumulation of turnover products and controlling pathogens to preserve eye homeostasis and vision. The complement system is a double-edged sword that is essential for protection but may also become harmful and contribute to eye pathology. Here, we review the evidence for the involvement of complement system dysregulation in age-related macular degeneration, glaucoma, uveitis, and neuromyelitis optica, highlighting the relationship between morphogical changes and complement system protein expression and regulation in these diseases...
June 13, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28619428/neuromyelitis-optica-presenting-with-horner-syndrome-a-case-report-and-review-of-literature
#4
İrem Fatma Uludağ, Alp Sarıteke, Levent Öcek, Yaşar Zorlu, Ufuk Şener, Figen Tokuçoğlu, Burhanettin Uludağ
Neuromyelitis optica (NMO) is a demyelinating disease of the central nervous system that predominantly affects the spinal cord and optic nerves. We describe a 19 years old woman with left Horner syndrome (HS), who was diagnosed as NMO with characteristic longitudinally extensive myelitis and positive serum aquaporin-4 immunoglobulin G antibodies (AQP4-IgG). Our report describes one of the very rare ocular motor symptoms in NMO patients.
May 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28615429/diagnostic-algorithm-for-relapsing-acquired-demyelinating-syndromes-in-children
#5
Yael Hacohen, Kshitij Mankad, W K Chong, Frederik Barkhof, Angela Vincent, Ming Lim, Evangeline Wassmer, Olga Ciccarelli, Cheryl Hemingway
OBJECTIVE: To establish whether children with relapsing acquired demyelinating syndromes (RDS) and myelin oligodendrocyte glycoprotein antibodies (MOG-Ab) show distinctive clinical and radiologic features and to generate a diagnostic algorithm for the main RDS for clinical use. METHODS: A panel reviewed the clinical characteristics, MOG-Ab and aquaporin-4 (AQP4) Ab, intrathecal oligoclonal bands, and Epstein-Barr virus serology results of 110 children with RDS. A neuroradiologist blinded to the diagnosis scored the MRI scans...
June 14, 2017: Neurology
https://www.readbyqxmd.com/read/28608315/effectiveness-of-low-dose-of-rituximab-compared-with-azathioprine-in-chinese-patients-with-neuromyelitis-optica-an-over-2-year-follow-up-study
#6
Meini Zhang, Chuntao Zhang, Peng Bai, Huiru Xue, Guilian Wang
Neuromyelitis optical (NMO) and neuromyelitis optical spectrum disorder (NMOSD) are inflammatory autoimmune demyelination diseases affecting the central nervous system. We investigated the efficiency of low-dose rituximab treatment in 31 Chinese patients with NMO/NMOSD across a median period of 2.29 ± 0.97 years and azathioprine combined with corticosteroid treatment in 34 Chinese patients with NMO/NMOSD across a median period of 2.61 ± 0.94 years. Among the rituximab-treated patients, the mean Expanded Disability Status Scale (EDSS) was 5...
June 12, 2017: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/28607119/geographical-differences-in-preventative-therapies-for-neuromyelitis-optica-spectrum-disorder
#7
EDITORIAL
Masahiro Mori, Akiyuki Uzawa, Satoshi Kuwabara
No abstract text is available yet for this article.
June 12, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28607118/a-step-forward-towards-personalised-immunosuppressive-therapy-in-neuromyelitis-optica-spectrum-disorder
#8
EDITORIAL
Su-Hyun Kim, Ho Jin Kim
No abstract text is available yet for this article.
June 12, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28601290/suspected-bacterial-meningomyelitis-the-first-presenting-clinical-feature-of-neuromyelitis-optica-spectrum-disorder
#9
Xiang Li, Jie Lin, Sipei Pan, Yiyun Weng, Jia Li, Xu Zhang, Junhui Xia, Qiaowen Tong
A rare case of neuromyelitis optica spectrum disorder, suspected to be bacterial meningomyelitis as the initial manifestation, is reported. The patient presented with initial symptoms of meningomyelitis and fever. Cerebrospinal fluid analysis revealed pleocytosis (1280×10(6)/L [98% lymphocytes]) and glucose level of 1.8mmol/L. Magnetic resonance imaging revealed >3 vertebral, longitudinally extensive transverse myelitis and area postrema lesions. Right optic neuritis was experienced 20months after the first attack...
August 15, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/28601284/aquaporin-4-antibody-positive-neuromyelitis-optica-spectrum-disorder-associated-with-esophageal-cancer
#10
Tomoya Kon, Tatsuya Ueno, Chieko Suzuki, Jinichi Nunomura, Shohei Igarashi, Tsugumi Sato, Masahiko Tomiyama
Autoimmune diseases are sometimes associated with neoplasms. A 70-year-old Japanese woman with myelitis, seropositive for aquaporin-4 (AQP4) antibody, was diagnosed with neuromyelitis optica spectrum disorder (NMOSD); thereafter an esophageal squamous cell carcinoma was identified. Immunohistochemically, her cancer was anti-AQP4 antibody negative. Her symptoms, imaging findings and AQP4 titer markedly improved with corticosteroid and anti-cancer therapies. Although AQP4 may be a paraneoplastic antigen, paraneoplastic syndrome could not be definitively diagnosed in this case...
August 15, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/28601281/association-of-cd58-gene-polymorphisms-with-nmo-spectrum-disorders-in-a-han-chinese-population
#11
Ju Liu, Ziyan Shi, Zhiyun Lian, Hongxi Chen, Qin Zhang, Huiru Feng, Xiaohui Miao, Qin Du, Hongyu Zhou
This study aimed to perform a comprehensive assessment of the association between CD58 polymorphisms and the risk of neuromyelitis optica spectrum disorders (NMOSD) in a Han Chinese population. Nine single-nucleotide polymorphisms (SNPs) were genotyped in 230 NMOSD patients and 487 healthy controls. Five SNPs were significantly associated with an increased risk of NMOSD (rs2300747, rs1335532, rs56302466, rs1016140, and rs12044852). The haplotype TAGCCCAA significantly increased the risk of NMOSD, while TATTACGG reduced the risk...
August 15, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/28601277/late-onset-neuromyelitis-optica-mimicking-an-acute-stroke-in-an-elderly-patient
#12
Kushak Suchdev, Sara Razmjou, Praveen Venkatachalam, Omar A Khan, Wazim Mohamed, Mohammed S Ibrahim
Neuromyelitis optica spectrum disorder (NMOSD) was recently proposed as a unifying term for Neuromyelitis optica (NMO) and related syndromes to incorporate patients with NMO antibody but without the full clinical spectrum. NMO is a rare, demyelinating condition which predominantly affects females with a peak incidence in the third and fourth decade of life. We report a case of NMOSD in an elderly patient with extremely late onset (>80years) of disease. The patient presented with findings of sudden onset unilateral symptoms, which is extremely unusual for NMOSD...
August 15, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/28600575/altered-humoral-immunity-to-mycobacterial-antigens-in-japanese-patients-affected-by-inflammatory-demyelinating-diseases-of-the-central-nervous-system
#13
Davide Cossu, Kazumasa Yokoyama, Yuji Tomizawa, Eiichi Momotani, Nobutaka Hattori
Mycobacterium avium subsp. paratuberculosis (MAP) and Mycobacterium bovis (BCG) have been associated to several human autoimmune diseases such as multiple sclerosis (MS), but there are conflicting evidence on the issue. The objective of this study is to evaluate their role in Japanese patients affected by inflammatory demyelinating disorders of the central nervous system (IDDs). A total of 97 IDDs subjects including 51 MS and 46 neuromyelitis optica spectrum disorder (NMOSD) patients, and 34 healthy controls (HCs) were tested for the detection of IgG, IgM and IgA against mycobacterial antigens by indirect ELISA...
June 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28599993/hiccups-as-herald-neuromyelitis-optica-spectrum-disorder
#14
Akshjot Puri, Michael Chesser, Keith Chan, Viswanatha Kharidi
No abstract text is available yet for this article.
June 6, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28598069/intractable-vomiting-and-hiccups-as-a-presenting-symptom-of-neuromyelitis-optica-spectrum-disorder
#15
Deepali Endole, Jui Jade, Hemali Advani, B S Singhal
No abstract text is available yet for this article.
May 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28591957/-correlates-of-fatigue-in-patients-with-neuromyelitis-optica
#16
Hong-Xi Chen, Zi-Yan Shi, Hui-Ru Feng, Hong-Yu Zhou
OBJECTIVES: To determine clinical characteristics associated with fatigue in patients with neuromyelitis optica (NMO). METHODS: A questionnaire survey was conducted in NMO patients, measuring fatigue using the fatigue impact scale (FIS). RESULTS: A total of 64 NMO patients (mean age: 50.0 years; male/female: 3/61) completed the survey: 71.9% were NMO-IgG seropositive and 43 (67.2%) received immunosuppressive treatments. The patients obtained a global FIS score of 64...
July 2016: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28589164/cns-aquaporin-4-specific-b-cells-connect-with-multiple-b-cell-compartments-in-neuromyelitis-optica-spectrum-disorder
#17
Markus C Kowarik, David Astling, Christiane Gasperi, Scott Wemlinger, Hannah Schumann, Monika Dzieciatkowska, Alanna M Ritchie, Bernhard Hemmer, Gregory P Owens, Jeffrey L Bennett
OBJECTIVES: Neuromyelitis optica spectrum disorder (NMOSD) is a severe inflammatory disorder of the central nervous system (CNS) targeted against aquaporin-4 (AQP4). The origin and trafficking of AQP4-specific B cells in NMOSD remains unknown. METHODS: Peripheral (n = 7) and splenic B cells (n = 1) recovered from seven NMOSD patients were sorted into plasmablasts, naïve, memory, and CD27-IgD- double negative (DN) B cells, and variable heavy chain (VH) transcriptome sequences were generated by deep sequencing...
June 2017: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/28584663/clinical-pitfall-false-positive-aquaporin-4-igg-leading-to-misdiagnosis-of-neuromyelitis-optica-spectrum-disorder-in-patient-with-spinal-arteriovenous-fistula
#18
Suradech Suthiphosuwan, Jiwon Oh, Aditya Bharatha
INTRODUCTION: We report the cases of a 68-year-old male with a filum terminale arteriovenous fistula (AVF) who was initially misdiagnosed with neuromyelitis optica spectrum disorder (NMOSD) based on imaging findings and false-positive aquaporin-4 IgG (AQP4-IgG). CASE PRESENTATION: A 68-year-old male presented with slowly progressive weakness and numbness in his bilateral lower extremities. He was initially diagnosed with NMOSD and treated with immunosuppressive therapy based on findings of extensive spinal cord edema on magnetic resonance imaging (MRI) and initial negative spinal angiography as well as positive AQP4-IgG...
2017: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/28583039/experimental-models-of-autoimmune-demyelinating-diseases-in-nonhuman-primates
#19
Lev Stimmer, Claire-Maëlle Fovet, Ché Serguera
Human idiopathic inflammatory demyelinating diseases (IIDD) are a heterogeneous group of autoimmune inflammatory and demyelinating disorders of the central nervous system (CNS). These include multiple sclerosis (MS), the most common chronic IIDD, but also rarer disorders such as acute disseminated encephalomyelitis (ADEM) and neuromyelitis optica (NMO). Great efforts have been made to understand the pathophysiology of MS, leading to the development of a few effective treatments. Nonetheless, IIDD still require a better understanding of the causes and underlying mechanisms to implement more effective therapies and diagnostic methods...
January 1, 2017: Veterinary Pathology
https://www.readbyqxmd.com/read/28580877/clinical-commentary-on-aquaporin-4-igg-positive-neuromyelitis-optica-spectrum-disorder-with-recurrent-short-partial-transverse-myelitis-and-favorable-prognosis-two-new-cases-by-wang-et-al
#20
Eoin P Flanagan
No abstract text is available yet for this article.
June 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
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