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adipose crosstalk

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https://www.readbyqxmd.com/read/28925018/mmp-2-and-notch-signal-pathway-regulate-migration-of-adipose-derived-stem-cells-and-chondrocytes-in-co-culture-systems
#1
Qi Zhang, Shuwen Deng, Ke Sun, Shiyu Lin, Yunfeng Lin, Bofeng Zhu, Xiaoxiao Cai
OBJECTIVES: The crosstalk between chondrocytes and adipose-derived stem cells (ADSCs) could regulate the secretion of multiple growth factors. However, it is not clear how the paracrine action in co-culture systems affect cell migration. This study focused on the changes of cell migration of ADSCs and chondrocytes in co-culture conditions. MATERIALS AND METHODS: Primary ADSCs and chondrocytes were isolated from Sprague-Dawley rat. Transwell co-culture systems, inoculated with ADSCs and chondrocytes, were established in vitro...
September 18, 2017: Cell Proliferation
https://www.readbyqxmd.com/read/28923965/sirt7-promotes-adipogenesis-in-the-mouse-by-inhibiting-autocatalytic-activation-of-sirt1
#2
Jian Fang, Alessandro Ianni, Christian Smolka, Olesya Vakhrusheva, Hendrik Nolte, Marcus Krüger, Astrid Wietelmann, Nicolas G Simonet, Juan M Adrian-Segarra, Alejandro Vaquero, Thomas Braun, Eva Bober
Sirtuins (Sirt1-Sirt7) are NAD(+)-dependent protein deacetylases/ADP ribosyltransferases, which play decisive roles in chromatin silencing, cell cycle regulation, cellular differentiation, and metabolism. Different sirtuins control similar cellular processes, suggesting a coordinated mode of action but information about potential cross-regulatory interactions within the sirtuin family is still limited. Here, we demonstrate that Sirt1 requires autodeacetylation to efficiently deacetylate targets such as p53, H3K9, and H4K16...
September 18, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28915700/the-fat-and-the-bad-mature-adipocytes-key-actors-in-tumor-progression-and-resistance
#3
REVIEW
Minh Ngoc Duong, Aline Geneste, Frederique Fallone, Xia Li, Charles Dumontet, Catherine Muller
Growing evidence has raised the important roles of adipocytes as an active player in the tumor microenvironment. In many tumors adipocytes are in close contact with cancer cells. They secrete various factors that can mediate local and systemic effects. The adipocyte-cancer cell crosstalk leads to phenotypical and functional changes of both cell types, which can further enhance tumor progression. Moreover, obesity, which is associated with an increase in adipose mass and an alteration of adipose tissue, has been established as a risk factor for cancer incidence and cancer-related mortality...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28888046/gap-junctional-intercellular-communication-in-adipose-derived-stromal-stem-cells-is-cell-density-dependent-and-positively-impacts-adipogenic-differentiation
#4
Wiesner Miriam, Berberich Oliver, Hoefner Christiane, Blunk Torsten, Bauer-Kreisel Petra
Adipose-derived stromal/stem cells (ASCs) represent a widely used cell source with multi-lineage differentiation capacity in approaches for tissue engineering and regenerative medicine. Despite the multitude of literature on their differentiation capacity, little is reported about the physiological properties contributing to and controlling the process of lineage differentiation. Direct intercellular communication between adjacent cells via gap junctions has been shown to modulate differentiation processes in other cell types, with connexin 43 (Cx43) being the most abundant isoform of the gap junction-forming connexins...
September 9, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28864539/signals-from-the-adipose-microenvironment-and-the-obesity-cancer-link-a-systematic-review
#5
REVIEW
Caroline Himbert, Mahmoud Delphan, Dominique Scherer, Laura W Bowers, Stephen Hursting, Cornelia M Ulrich
Obesity and its associated metabolic dysregulation are established risk factors for many cancers. However, the biologic mechanisms underlying this relationship remain incompletely understood. Given the rising rates of both obesity and cancer worldwide, and the challenges for many people to lose excess adipose tissue, a systematic approach to identify potential molecular and metabolic targets is needed to develop effective mechanism-based strategies for the prevention and control of obesity-driven cancer. Epidemiologic, clinical, and preclinical data suggest that within the growth-promoting, proinflammatory microenvironment accompanying obesity, crosstalk between adipose tissue (comprised of adipocytes, macrophages and other cells) and cancer-prone cells may occur via obesity-associated hormones, cytokines, and other mediators that have been linked to increased cancer risk and/or progression...
September 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28844882/the-lymphatic-vasculature-its-role-in-adipose-metabolism-and-obesity
#6
REVIEW
Noelia Escobedo, Guillermo Oliver
Obesity is a key risk factor for metabolic and cardiovascular diseases, and although we understand the mechanisms regulating weight and energy balance, the causes of some forms of obesity remain enigmatic. Despite the well-established connections between lymphatics and lipids, and the fact that intestinal lacteals play key roles in dietary fat absorption, the function of the lymphatic vasculature in adipose metabolism has only recently been recognized. It is well established that angiogenesis is tightly associated with the outgrowth of adipose tissue, as expanding adipose tissue requires increased nutrient supply from blood vessels...
August 22, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28843066/deriving-vascular-smooth-muscle-cells-from-mesenchymal-stromal-cells-evolving-differentiation-strategies-and-current-understanding-of-their-mechanisms
#7
REVIEW
Xiaoqing Zhang, Michelle P Bendeck, Craig A Simmons, J Paul Santerre
Vascular smooth muscle cells (VSMCs) play essential roles in regulating blood vessel form and function. Regeneration of functional vascular smooth muscle tissue to repair vascular diseases is an area of intense research in tissue engineering and regenerative medicine. For functional vascular smooth muscle tissue regeneration to become a practical therapy over the next decade, the field will need to have access to VSMC sources that are effective, robust and safe. While pluripotent stem cells hold good future promise to this end, more immediate translation is expected to come from approaches that generate functional VSMCs from adult sources of multipotent adipose-derived and bone marrow-derived mesenchymal stromal cells (ASCs and BMSCs)...
August 15, 2017: Biomaterials
https://www.readbyqxmd.com/read/28831023/mild-cold-induced-thermogenesis-are-bat-and-skeletal-muscle-synergistic-partners
#8
Naresh C Bal, Santosh K Maurya, Sunil Pani, Chinmayee Sethy, Ananya Banerjee, Sarita Das, Srinivas Patanaik, Chanakya N Kundu
There are two well-described thermogenic sites; brown adipose tissue (BAT) and skeletal muscle, which utilize distinct mechanisms of heat production. In BAT, mitochondrial metabolism is the molecular basis of heat generation, while it serves only a minor role in supplying  energy for thermogenesis in muscle. Here, we wanted to document changes in mitochondrial ultrastructure in these two tissue types upon adaptation to mild (16°C) and severe (4°C) cold in mice. When reared at thermoneutrality (29°C), mitochondria in both tissues were loosely packed with irregular cristae...
August 22, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28795382/liver-adipose-tissue-crosstalk-a-key-player-in-the-pathogenesis-of-glucolipid-metabolic-disease
#9
De-Wei Ye, Xiang-Lu Rong, Ai-Min Xu, Jiao Guo
Glucolipid metabolic disease (GLMD), a complex of interrelated disorders in glucose and lipid metabolism, has become one of the leading chronic diseases causing public and clinical problem worldwide. As the metabolism of lipid and glucose is a highly coordinated process under both physiological and diseased conditions, the impairment in the signals corresponding to the metabolism of either lipid or glucose represents the common mechanism underlying the pathogenesis of GLMD. The liver and adipose tissue are the major metabolic organs responsible for energy utilization and storage, respectively...
June 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28789665/evaluating-the-evidence-for-macrophage-presence-in-skeletal-muscle-and-its-relation-to-insulin-resistance-in-obese-mice-and-humans-a-systematic-review-protocol
#10
Meha Bhatt, Srikesh Rudrapatna, Laura Banfield, Rachel Bierbrier, Pei-Wen Wang, Kuan-Wen Wang, Lehana Thabane, M Constantine Samaan
OBJECTIVES: The current global rates of obesity and type 2 diabetes are staggering. In order to implement effective management strategies, it is imperative to understand the mechanisms of obesity-induced insulin resistance and diabetes. Macrophage infiltration and inflammation of the adipose tissue in obesity is a well-established paradigm, yet the role of macrophages in muscle inflammation, insulin resistance and diabetes is not adequately studied. In this systematic review, we will examine the evidence for the presence of macrophages in skeletal muscle of obese humans and mice, and will assess the association between muscle macrophages and insulin resistance...
August 8, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28752043/adipocyte-lipid-synthesis-coupled-to-neuronal-control-of-thermogenic-programming
#11
Adilson Guilherme, David J Pedersen, Elizabeth Henchey, Felipe S Henriques, Laura V Danai, Yuefei Shen, Batuhan Yenilmez, DaeYoung Jung, Jason K Kim, Irfan J Lodhi, Clay F Semenkovich, Michael P Czech
BACKGROUND: The de novo biosynthesis of fatty acids (DNL) through fatty acid synthase (FASN) in adipocytes is exquisitely regulated by nutrients, hormones, fasting, and obesity in mice and humans. However, the functions of DNL in adipocyte biology and in the regulation of systemic glucose homeostasis are not fully understood. METHODS & RESULTS: Here we show adipocyte DNL controls crosstalk to localized sympathetic neurons that mediate expansion of beige/brite adipocytes within inguinal white adipose tissue (iWAT)...
August 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/28745372/systems-level-organization-of-non-alcoholic-fatty-liver-disease-progression-network
#12
K Shubham, L Vinay, P K Vinod
Non-Alcoholic Fatty Liver Disease (NAFLD) is a complex spectrum of diseases ranging from simple steatosis to Non-Alcoholic Steatohepatitis (NASH) with fibrosis, which can progress to cirrhosis and hepatocellular carcinoma. The pathogenesis of NAFLD is complex, involving crosstalk between multiple organs, cell-types, and environmental and genetic factors. Dysfunction of the adipose tissue plays a central role in NAFLD progression. Here, we analysed transcriptomics data obtained from the Visceral Adipose Tissue (VAT) of NAFLD patients to understand how the VAT metabolism is altered at the genome scale and co-regulated with other cellular processes during the progression from obesity to NASH with fibrosis...
August 22, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28669758/muscle-directs-diurnal-energy-homeostasis-through-a-myokine-dependent-hormone-module-in-drosophila
#13
Xiao Zhao, Jason Karpac
Inter-tissue communication is critical to control organismal energy homeostasis in response to temporal changes in feeding and activity or external challenges. Muscle is emerging as a key mediator of this homeostatic control through consumption of lipids, carbohydrates, and amino acids, as well as governing systemic signaling networks. However, it remains less clear how energy substrate usage tissues, such as muscle, communicate with energy substrate storage tissues in order to adapt with diurnal changes in energy supply and demand...
July 10, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28667492/inflammation-cause-or-consequence-of-heart-failure-or-both
#14
REVIEW
Sophie Van Linthout, Carsten Tschöpe
PURPOSE OF REVIEW: With the intention to summarize the currently available evidence on the pathophysiological relevance of inflammation in heart failure, this review addresses the question whether inflammation is a cause or consequence of heart failure, or both. RECENT FINDINGS: This review discusses the diversity (sterile, para-inflammation, chronic inflammation) and sources of inflammation and gives an overview of how inflammation (local versus systemic) can trigger heart failure...
August 2017: Current Heart Failure Reports
https://www.readbyqxmd.com/read/28663846/flexible-silicon-sensors-for-diffuse-reflectance-spectroscopy-of-tissue
#15
David M Miller, Nan M Jokerst
Diffuse reflectance spectroscopy (DRS) is being used in exploratory clinical applications such as cancer margin assessment on excised tissue. However, when interrogating nonplanar tissue anomalies can arise from non-uniform pressure. Herein is reported the design, fabrication, and test of flexible, thin film silicon photodetectors (PDs) bonded to a flexible substrate designed for use in conformal DRS. The PDs have dark currents and responsivities comparable to conventional Si PDs, and were characterized while flat and while flexed at multiple radii of curvature using liquid phantoms mimicking adipose and malignant breast tissue...
March 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28640452/role-of-epicardial-adipose-tissue-in-health-and-disease-a-matter-of-fat
#16
Bénédicte Gaborit, Coralie Sengenes, Patricia Ancel, Alexis Jacquier, Anne Dutour
Epicardial adipose tissue (EAT) is a small but very biologically active ectopic fat depot that surrounds the heart. Given its rapid metabolism, thermogenic capacity, unique transcriptome, secretory profile, and simply measurability, epicardial fat has drawn increasing attention among researchers attempting to elucidate its putative role in health and cardiovascular diseases. The cellular crosstalk between epicardial adipocytes and cells of the vascular wall or myocytes is high and suggests a local role for this tissue...
June 18, 2017: Comprehensive Physiology
https://www.readbyqxmd.com/read/28621338/adipose-tissue-crosstalk-between-adipocytes-and-neurons
#17
Claire Greenhill
No abstract text is available yet for this article.
August 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28607107/myeloid-sirtuin-6-deficiency-causes-insulin-resistance-in-high-fat-diet-fed-mice-by-eliciting-macrophage-polarization-toward-an-m1-phenotype
#18
Youngyi Lee, Sun-O Ka, Hye-Na Cha, Yu-Na Chae, Mi-Kyung Kim, So-Young Park, Eun Ju Bae, Byung-Hyun Park
Obesity-related insulin resistance is closely associated with macrophage accumulation and subsequent cytokine release in local tissues. Sirtuin (Sirt) 6 is known to exert an anti-inflammatory function but its role in macrophages in the context of obesity has not been investigated. Here, we generated myeloid-specific Sirt6 knockout mice (mS6KO) and investigated the metabolic characteristics after high-fat diet (HFD) feeding for 16 weeks. Compared with their wild type littermates, HFD-fed mS6KO mice exhibited greater increases in body weight, fasting blood glucose- and insulin-levels, hepatic steatosis, glucose intolerance, and insulin resistance...
June 12, 2017: Diabetes
https://www.readbyqxmd.com/read/28599253/alantolactone-improves-palmitate-induced-glucose-intolerance-and-inflammation-in-both-lean-and-obese-states-in-vitro-adipocyte-and-adipocyte-macrophage-co-culture-system
#19
Minjee Kim, Kwangho Song, Yeong Shik Kim
Obesity is characterized by a massive infiltration of the adipose tissue by macrophages. Adipocytes, together with macrophages create a crosstalk between inflammation and insulin resistance. Excess saturated FFA, such as palmitate, absorbed via the portal system may cause glucose intolerance and inflammation, which leads to insulin resistance. In this study, we aimed to evaluate the potency of alantolactone (AL), a sesquiterpene lactone isolated from Inula helenium in reducing palmitate-induced glucose intolerance, fat accumulation, and inflammation in 3T3-L1 adipocytes and adipocyte-macrophage co-culture system (3T3-L1-RAW264...
June 6, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28598385/the-roles-of-long-non-protein-coding-rnas-in-osteo-adipogenic-lineage-commitment
#20
REVIEW
Hirotaka Yoshioka, Yuji Yoshiko
Osteoblasts and adipocytes share a common mesenchymal progenitor in the bone marrow. This implies that a reciprocal relationship exists between osteogenic and adipogenic differentiation. Further, cells of osteoblast lineage transdifferentiate into adipocytes under some circumstances. Dysregulation of osteo-adipogenic fate-determination leads to bone diseases such as osteoporosis, accompanied by an increase in bone marrow adipose tissue. Thus, the fine-tuning of osteo-adipogenesis is necessary for bone homeostasis...
June 9, 2017: International Journal of Molecular Sciences
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