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adipose crosstalk

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https://www.readbyqxmd.com/read/29775611/reduced-adiposity-by-compensatory-wat-browning-upon-ibat-removal-in-mice
#1
Zhengyu Piao, Baiqiang Zhai, Xiaoxiao Jiang, Meng Dong, Changguo Yan, Jun Lin, Wanzhu Jin
The strong effects of classic brown adipose tissue (BAT) and recruited beige adipocytes in treatment of obesity and metabolic syndrome have been attracting increasing research interest. Cold treatment is an effective, convenient approach to stimulate BAT activity and induce white adipose tissue (WAT) browning. Here, we utilized prolonged cold exposure (from 2 h to 2 weeks in a 4° cold chamber) to elucidate dynamic changes in BAT and in WAT browning during acute and chronic cold exposure in mice. BAT mass decreased quickly, with reduced lipid droplet sizes within 8 h of cold exposure owing to the utilization of BAT pre-storage triglycerides, and subsequently increased during prolonged cold exposure...
May 15, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29773671/targeted-inhibition-of-cd74-attenuates-adipose-cox-2-mif-mediated-m1-macrophage-polarization-and-retards-obesity-related-adipose-tissue-inflammation-and-insulin-resistance
#2
Pei-Chi Chan, Ting-Ni Wu, Ying-Chuan Chen, Chieh-Hua Lu, Martin Wabitsch, Yu-Feng Tian, Po-Shiuan Hsieh
Adipose tissue (AT) inflammation is crucial to the development of obesity-associated insulin resistance. Our aim was to investigate the contribution of COX-2/MIF-mediated crosstalk between hypertrophic adipocytes and macrophages to the etiology of AT inflammation and involvement of CD74 using human SGBS adipocytes, THP-1 macrophages and mice fed a high-fat (HF) diet. The MIF and CD74 mRNA levels in the adipocytes and SVCs (stromal vascular cells) of white fat were highly correlated with body weight, HOMA-IR and adipose macrophage marker expression levels, especially those in SVCs...
May 17, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29767564/interorgan-metabolic-crosstalk-in-human-insulin-resistance
#3
Sofiya Gancheva, Tomas Jelenik, Elisa Álvarez-Hernández, Michael Roden
Excessive energy intake and reduced energy expenditure drive the development of insulin resistance and metabolic diseases such as obesity and type 2 diabetes mellitus. Metabolic signals derived from dietary intake or secreted from adipose tissue, gut, and liver contribute to energy homeostasis. Recent metabolomic studies identified novel metabolites and enlarged our knowledge on classic metabolites. This review summarizes the evidence of their roles as mediators of interorgan crosstalk and regulators of insulin sensitivity and energy metabolism...
July 1, 2018: Physiological Reviews
https://www.readbyqxmd.com/read/29743077/role-of-hormonal-and-inflammatory-alterations-in-obesity-related-reproductive-dysfunction-at-the-level-of-the-hypothalamic-pituitary-ovarian-axis
#4
REVIEW
Michelle Goldsammler, Zaher Merhi, Erkan Buyuk
BACKGROUND: Besides being a risk factor for multiple metabolic disorders, obesity could affect female reproduction. While increased adiposity is associated with hormonal changes that could disrupt the function of the hypothalamus and the pituitary, compelling data suggest that obesity-related hormonal and inflammatory changes could directly impact ovarian function. OBJECTIVE: To review the available data related to the mechanisms by which obesity, and its associated hormonal and inflammatory changes, could affect the female reproductive function with a focus on the hypothalamic-pituitary-ovarian (HPO) axis...
May 9, 2018: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/29738274/renal-injury-in-seipin-deficient-lipodystrophic-mice-and-its-reversal-by-adipose-tissue-transplantation-or-leptin-administration-alone-adipose-tissue-kidney-crosstalk
#5
Xue-Jing Liu, Xiao-Yue Wu, Huan Wang, Su-Xia Wang, Wei Kong, Ling Zhang, George Liu, Wei Huang
Seipin deficiency is responsible for type 2 congenital generalized lipodystrophy with severe loss of adipose tissue (AT) and could lead to renal failure in humans. However, the effect of Seipin on renal function is poorly understood. Here we report that Seipin knockout (SKO) mice exhibited impaired renal function, enlarged glomerular and mesangial surface areas, renal depositions of lipid, and advanced glycation end products. Elevated glycosuria and increased electrolyte excretion were also detected. Relative renal gene expression in fatty acid oxidation and reabsorption pathways were impaired in SKO mice...
May 8, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29735541/multiplex-quantification-identifies-novel-exercise-regulated-myokines-cytokines-in-plasma-and-in-glycolytic-and-oxidative-skeletal-muscle
#6
Hannah Little, Stefanie Y Tan, Francesca Cali, Susana Rodriguez, Xia Lei, Andrew Wolfe, Christopher Hug, G William Wong
Exercise is known to confer major health benefits, but the underlying mechanisms are not well understood. The systemic effects of exercise on multi-organ systems are thought to be partly due to myokines/cytokines secreted by skeletal muscle. The extent to which exercise alters cytokine expression and secretion in different muscle fiber types has not been systematically examined.  Here, we assessed changes in 66 mouse cytokines in serum, and in glycolytic (plantaris) and oxidative (soleus) muscles, in response to sprint, endurance, or chronic wheel running...
May 7, 2018: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29721071/adipocyte-derived-exosomal-mir-27a-induces-insulin-resistance-in-skeletal-muscle-through-repression-of-ppar%C3%AE
#7
Yang Yu, Hongwei Du, Shengnan Wei, Linjing Feng, Junnan Li, Fan Yao, Ming Zhang, Grant M Hatch, Li Chen
The mechanism by which adipocyte-derived endocrine factors promote insulin resistance in skeletal muscle are not fully understood. MiR-27a is highly expressed in sera of obese individuals with prediabetes and T2DM, and mainly derived by adipose tissues. Thus, miR-27a secreted into circulation by adipose tissue may regulate insulin resistance in skeletal muscle. Methods: The association between miR-27a and insulin resistance in skeletal muscle was determined in obese children, high-fat diet-induced miR-27a knockdown obese mice, db/db mice and C2C12 cells overexpressing miR-27a...
2018: Theranostics
https://www.readbyqxmd.com/read/29719250/mitophagy-directs-muscle-adipose-crosstalk-to-alleviate-dietary-obesity
#8
Tingting Fu, Zhisheng Xu, Lin Liu, Qiqi Guo, Hao Wu, Xijun Liang, Danxia Zhou, Liwei Xiao, Lei Liu, Yong Liu, Min-Sheng Zhu, Quan Chen, Zhenji Gan
The quality of mitochondria in skeletal muscle is essential for maintaining metabolic homeostasis during adaptive stress responses. However, the precise control mechanism of muscle mitochondrial quality and its physiological impacts remain unclear. Here, we demonstrate that FUNDC1, a mediator of mitophagy, plays a critical role in controlling muscle mitochondrial quality as well as metabolic homeostasis. Skeletal-muscle-specific ablation of FUNDC1 in mice resulted in LC3-mediated mitophagy defect, leading to impaired mitochondrial energetics...
May 1, 2018: Cell Reports
https://www.readbyqxmd.com/read/29709261/cancer-as-a-matter-of-fat-the-crosstalk-between-adipose-tissue-and-tumors
#9
REVIEW
Ernst Lengyel, Liza Makowski, John DiGiovanni, Mikhail G Kolonin
Obesity has been linked to the increased risk and aggressiveness of many types of carcinoma. A state of chronic inflammation in adipose tissue (AT), resulting in genotoxic stress, may contribute to carcinogenesis and cancer initiation. Evidence that AT plays a role in cancer aggressiveness is solid and mounting. During cancer progression, tumor cells engage in a metabolic symbiosis with adjacent AT. Mature adipocytes provide adipokines and lipids to cancer cells, while stromal and immune cells from AT infiltrate carcinomas and locally secrete paracrine factors within the tumor microenvironment...
May 2018: Trends in Cancer
https://www.readbyqxmd.com/read/29706566/fgf21-prevents-angiotensin-ii-induced-hypertension-and-vascular-dysfunction-by-activation-of-ace2-angiotensin-1-7-axis-in-mice
#10
Xuebo Pan, Yihui Shao, Fan Wu, Yuan Wang, Rongrong Xiong, Jujia Zheng, Haishan Tian, Baile Wang, Yanfang Wang, Yi Zhang, Zongsheng Han, Aijuan Qu, Haixia Xu, Aihua Lu, Tianxin Yang, Xiaokun Li, Aimin Xu, Jie Du, Zhuofeng Lin
Fibroblast growth factor 21 (FGF21) is a metabolic hormone with pleiotropic effects on glucose and lipid metabolism and insulin sensitivity. However, the role of FGF21 in hypertension remains elusive. Here we show that FGF21 deficiency significantly exacerbates angiotensin II-induced hypertension and vascular dysfunction, whereas such negative effects are reversed by replenishment of FGF21. Mechanistically, FGF21 acts on adipocytes and renal cells to promote induction of angiotensin-converting enzyme 2 (ACE2), which in turn converts angiotensin II to angiotensin-(1-7), then inhibits hypertension and reverses vascular damage...
April 24, 2018: Cell Metabolism
https://www.readbyqxmd.com/read/29593201/adipose-tissue-critical-contributor-to-the-development-of-prostate-cancer
#11
Uehara Hisanori, Tomoko Kobayashi, Minoru Matsumoto, Shunsuke Watanabe, Akiko Yoneda, Bando Yoshimi
The prostate is surrounded by periprostatic adipose tissue. Although adipose tissue was thought to play limited physiological roles, it has recently been recognized as an active endocrine organ, secreting growth factors and adipokines. Epidemiologically, obesity is associated with prostate cancer progression. A major mechanism to explain the link between obesity and cancer includes the insulin and insulin-like growth factor (IGF)-1 axis, sex steroids, and adipokines. When prostate cancer cells invade periprostatic adipose tissue, adipose tissue contributes to create the tumor microenvironment, mainly via adipokine secretion...
2018: Journal of Medical Investigation: JMI
https://www.readbyqxmd.com/read/29580841/long-non-coding-rnas-associated-with-metabolic-traits-in-human-white-adipose-tissue
#12
Hui Gao, Alastair Kerr, Hong Jiao, Chung-Chau Hon, Mikael Rydén, Ingrid Dahlman, Peter Arner
Long non-coding RNAs (lncRNAs) belong to a recently discovered class of molecules proposed to regulate various cellular processes. Here, we systematically analyzed their expression in human subcutaneous white adipose tissue (WAT) and found that a limited set was differentially expressed in obesity and/or the insulin resistant state. Two lncRNAs herein termed adipocyte-specific metabolic related lncRNAs, ASMER-1 and ASMER-2 were enriched in adipocytes and regulated by both obesity and insulin resistance. Knockdown of either ASMER-1 or ASMER-2 by antisense oligonucleotides in in vitro differentiated human adipocytes revealed that both genes regulated adipogenesis, lipid mobilization and adiponectin secretion...
March 15, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29562231/hepatocyte-secreted-dpp4-in-obesity-promotes-adipose-inflammation-and-insulin-resistance
#13
Devram S Ghorpade, Lale Ozcan, Ze Zheng, Sarah M Nicoloro, Yuefei Shen, Emily Chen, Matthias Blüher, Michael P Czech, Ira Tabas
Obesity-induced metabolic disease involves functional integration among several organs via circulating factors, but little is known about crosstalk between liver and visceral adipose tissue (VAT). In obesity, VAT becomes populated with inflammatory adipose tissue macrophages (ATMs). In obese humans, there is a close correlation between adipose tissue inflammation and insulin resistance, and in obese mice, blocking systemic or ATM inflammation improves insulin sensitivity. However, processes that promote pathological adipose tissue inflammation in obesity are incompletely understood...
March 29, 2018: Nature
https://www.readbyqxmd.com/read/29546647/bone-best-papers-of-the-year-2017
#14
REVIEW
Michaël R Laurent
An overview of selected papers related to bone published in 2017 is provided. PURPOSE: This paper accompanies a lecture at the 2018 Belgian Bone Club annual Clinical Update Symposium held in Brussels on January 20th, discussing the best papers (in the opinion of the author) published in the previous year. METHODS: A PubMed search using the keyword "bone" and articles published in 2017. RESULTS: Hot topics include screening for osteoporosis, novel anabolic drugs such as romosozumab and abaloparatide for osteoporosis and rare metabolic bone diseases, as well as long-term efficacy of denosumab and possible risk of multiple vertebral fractures following its discontinuation...
March 15, 2018: Archives of Osteoporosis
https://www.readbyqxmd.com/read/29514067/visceral-adipose-tissue-immune-homeostasis-is-regulated-by-the-crosstalk-between-adipocytes-and-dendritic-cell-subsets
#15
Claire E Macdougall, Elizabeth G Wood, Jakob Loschko, Valeria Scagliotti, Féaron C Cassidy, Mark E Robinson, Niklas Feldhahn, Leandro Castellano, Mathieu-Benoit Voisin, Federica Marelli-Berg, Carles Gaston-Massuet, Marika Charalambous, M Paula Longhi
Visceral adipose tissue (VAT) has multiple roles in orchestrating whole-body energy homeostasis. In addition, VAT is now considered an immune site harboring an array of innate and adaptive immune cells with a direct role in immune surveillance and host defense. We report that conventional dendritic cells (cDCs) in VAT acquire a tolerogenic phenotype through upregulation of pathways involved in adipocyte differentiation. While activation of the Wnt/β-catenin pathway in cDC1 DCs induces IL-10 production, upregulation of the PPARγ pathway in cDC2 DCs directly suppresses their activation...
March 6, 2018: Cell Metabolism
https://www.readbyqxmd.com/read/29492879/metabolic-coupling-between-bone-marrow-adipose-tissue-and-hematopoiesis
#16
REVIEW
Russell T Turner, Stephen A Martin, Urszula T Iwaniec
PURPOSE OF REVIEW: Mesenchymal stem cells (MSCs) located in the bone marrow have the capacity to differentiate into multiple cell lineages, including osteoblast and adipocyte. Adipocyte density within marrow is inversely associated with bone mass during aging and in some pathological conditions, contributing to the prevailing view that marrow adipocytes play a largely negative role in bone metabolism. However, a negative association between marrow adipocytes and bone balance is not universal...
April 2018: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/29467719/physical-exercise-enhanced-heat-shock-protein-60-expression-and-attenuated-inflammation-in-the-adipose-tissue-of-human-diabetic-obese
#17
Abdelkrim Khadir, Sina Kavalakatt, Preethi Cherian, Samia Warsame, Jehad Ahmed Abubaker, Mohammed Dehbi, Ali Tiss
Heat shock protein 60 (HSP60) is a key protein in the crosstalk between cellular stress and inflammation. However, the status of HSP60 in diabetes and obesity is unclear. In the present study, we investigated the hypothesis that HSP60 expression levels in the adipose tissue of human obese adults with and without diabetes are different and physical exercise might affect these levels. Subcutaneous adipose tissue (SAT) and blood samples were collected from obese adults with and without diabetes ( n  = 138 and n  = 92, respectively, at baseline; n  = 43 for both groups after 3 months of physical exercise)...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29464937/vascular-dysfunction-elicited-by-a-cross-talk-between-periaortic-adipose-tissue-and-the-vascular-wall-is-reversed-by-pioglitazone
#18
Isabel Quesada, Jimena Cejas, Rodrigo García, Beatriz Cannizzo, Analía Redondo, Claudia Castro
AIM: Perivascular adipose tissue (PVAT) is in intimate contact with the vessel wall and extravascular PVAT-derived inflammatory mediators may adversely influence atherosclerotic plaque formation and stability through outside-to-inside signaling. We sought to investigate the role of PVAT on the atheroma development in an experimental animal model of metabolic syndrome (MS) associated with oxidative stress and low-grade inflammatory state. We also studied the effect of pioglitazone an insulin sensitizer, on the aortic wall and its surrounding PVAT, considering a bi-directional communication between both layers...
June 2018: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/29449715/leptin-and-brain-adipose-crosstalks
#19
REVIEW
Alexandre Caron, Syann Lee, Joel K Elmquist, Laurent Gautron
Interactions between the brain and distinct adipose depots have a key role in maintaining energy balance, thereby promoting survival in response to metabolic challenges such as cold exposure and starvation. Recently, there has been renewed interest in the specific central neuronal circuits that regulate adipose depots. Here, we review anatomical, genetic and pharmacological studies on the neural regulation of adipose function, including lipolysis, non-shivering thermogenesis, browning and leptin secretion. In particular, we emphasize the role of leptin-sensitive neurons and the sympathetic nervous system in modulating the activity of brown, white and beige adipose tissues...
February 16, 2018: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/29447836/sensory-denervation-of-inguinal-white-fat-modifies-sympathetic-outflow-to-white-and-brown-fat-in-siberian-hamsters
#20
REVIEW
Ngoc Ly T Nguyen, Bingzhong Xue, Timothy J Bartness
White adipose tissue (WAT) and brown adipose tissue (BAT) have sympathetic nervous system (SNS) and sensory innervations. Previous studies from our laboratory revealed central neuroanatomical evidence of WAT sensory and BAT SNS crosstalk with double labeling of inguinal WAT (IWAT) sensory and interscapular BAT (IBAT) SNS neurons. We previously demonstrated that WAT lipolysis increases IBAT temperature, but this effect is absent when IWAT afferents are surgically denervated, which severs both sensory and SNS nerves...
June 1, 2018: Physiology & Behavior
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