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post steroid injection side effects

Shih-Yi Yang, Jui-Yung Yang, Yen-Chang Hsiao, Shiow-Shuh Chuang
BACKGROUND: The formation of hypertrophic scaring (HSc) is an abnormal wound-healing response. In a previous study, an animal model with human scar tissue implanted into nude mice (BALB/c) has been successfully established. The effects of verapamil as well as combination therapy with verapamil and kenacort have been studied and compared. OBJECTIVE: To treat persistent hypertrophic scars, local injection of drugs composed of steroids, calcium channel blockers (CCBs), and interferon might be a good method...
January 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Gloria S Cheng, Brian M Ilfeld
OBJECTIVE: To review the published evidence regarding perioperative analgesic techniques for breast cancer-related surgery. DESIGN: Topical review. METHODS: Randomized, controlled trials (RCTs) were selected for inclusion in the review. Also included were large prospective series providing estimates of potential risks and technical reports and small case series demonstrating a new technique or approaches of interest to clinicians. RESULTS: A total of 514 abstracts were reviewed, with 284 studies meeting criteria for full review...
August 22, 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
Erin P Herlihy, John P Kelly, Robert Sidbury, Jonathan A Perkins, Avery H Weiss
BACKGROUND: Periocular infantile hemangiomas (PIH) can induce anisometropic astigmatism, a risk factor for amblyopia. Oral beta-blocker therapy has largely supplanted systemic or intralesional corticosteroids. The purpose of this study was to evaluate the effect and time course of these treatment modalities on visual acuity and induced astigmatism. METHODS: The medical records of patients with PIH treated with oral propanolol between November 2008 and July 2013 were retrospectively reviewed for data on visual acuity and astigmatism...
February 2016: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
Waylan Wong, Dermot P Maher, Daniel Iyayi, Raul Lopez, Bahman Shamloo, Howard Rosner, Roya Yumul
BACKGROUND: Fluoroscopically guided transforaminal epidural steroid injections (FG-TFESIs) have been shown to provide both immediate and long-term improvement in patient's self-reported pain. Administration of the lowest possible dose of epidural betamethasone is desired to minimize side effects while maintaining efficacy. We hypothesize that a 3 mg or a 6 mg dose of betamethasone will demonstrate equivalent analgesic properties. OBJECTIVES: To compare the analgesic efficacy of 3 mg and a 6 mg dose of betamethasone for use in FG-TFESI...
May 2015: Pain Physician
J V Roughan, H G M J Bertrand, H M Isles
BACKGROUND: Inflammation is thought to be a major contributor to post-surgical pain, so non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used analgesics. However, compared to rats, considerably less is known as to how successfully these prevent pain in mice. METHODS: A fluorescent COX-2 selective probe was used for the first time to evaluate the post-surgical anti-inflammatory effects of meloxicam, and automated behaviour analyses (HomeCageScan; HCS), the Mouse Grimace Scale (MGS) and body weight changes to assess its pain-preventative properties...
February 2016: European Journal of Pain: EJP
Nabeel Dastgir
OBJECTIVE: To explore the effect of extracorporeal shock wave therapy in patients with chronic plantar faciitis. METHODS: The prospective study was conducted at Department of Orhopaedic, Regional Hospital, Limerick, Ireland from January to December 2004 and comprised 70 heels in 62 patients with chronic plantar fasciitis in whom conventional conservative treatment consisting of non-steroidal anti-inflammatory drugs, heel cup, orthoses and/or shoe modifications, local steroid injections had failed, and they were treated with low energy extracorporeal shock wave therapy...
June 2014: JPMA. the Journal of the Pakistan Medical Association
Maryam Khodadadi, Shiva Basavaiah, Saeid Abediankenari
BACKGROUND: Main function of corpus luteum is progesterone synthesis that is significantly accompanied with an increase in levels of mRNA encoding of steroidogenic enzymes known as luteal markers. OBJECTIVE: This study was designed to evaluate effects of lithium chloride on the release of steroid hormones and steroidogenic enzymes in gonadotropin-stimulated rats. MATERIALS AND METHODS: Immature 23 days old Wistar rats were divided into 10 groups; each group comprised of 8 rats, and induced with single injection of pregnant mare's serum gonadotrophin (PMSG) and followed by single injection of human chorionic gonadotropin (hCG)...
May 2012: Iranian Journal of Reproductive Medicine
Paul G Talusan, Christopher P Miller, Ameya V Save, John S Reach
BACKGROUND: Foot and ankle pathology is common in the driving population. Local anesthetic steroid injections are frequent ambulatory treatments. Brake reaction time (BRT) has validated importance in motor vehicle safety. There are no prior studies examining the effect of foot and ankle pathology and injection treatment on the safe operation of motor vehicles. We studied BRT in patients with foot and ankle musculoskeletal disease before and after image-guided injection treatment. METHODS: A total of 37 participants were enrolled...
April 2015: Foot & Ankle Specialist
F Affas, S Eksborg, P Wretenberg, C Olofsson, N Stephanson, C-O Stiller
BACKGROUND: Local infiltration analgesia (LIA) with local anaesthetic (ropivacaine), a nonsteroidal anti-inflammatory drug (ketorolac) and epinephrine after lower extremity arthroplasty has gained increasing popularity during the last decade. This method has certain advantages, which include minimal systemic side effects, faster post-operative mobilization, earlier post-operative discharge from hospital and less opioid consumption. However, information regarding plasma concentrations of ketorolac after LIA mixture is insufficient to predict the risk of renal impairment in patients subjected to arthroplasty...
October 2014: Acta Anaesthesiologica Scandinavica
Chris Plastaras, Zachary McCormick, Donald Macron, Cynthia Garvan, Anand Joshi, Gary Chimes, Wesley Smeal, Joshua Rittenberg
BACKGROUND: In spite of the widespread performance of intra-articular zygapophyseal joint (IAZJ) injections, we know of no systematic analysis to date that examines the risks and types of adverse events when IAZJ injections are performed. OBJECTIVE: To describe the type, incidence, and factors contributing to adverse events associated with fluoroscopically guided IAZJ injections. STUDY DESIGN: A retrospective, cohort study of English-speaking adults aged 18 - 90 years who underwent fluoroscopically guided IAZJ injections between March 8, 2004, and April 19, 2007...
July 2014: Pain Physician
M C Peluffo, J Stanley, N Braeuer, A Rotgeri, K-H Fritzemeier, U Fuhrmann, B Buchmann, T Adevai, M J Murphy, M B Zelinski, B Lindenthal, J D Hennebold, R L Stouffer
STUDY QUESTION: Can administration of a prostaglandin (PG) E2 receptor 2 (PTGER2) antagonist prevent pregnancy in adult female monkeys by blocking periovulatory events in the follicle without altering menstrual cyclicity or general health? SUMMARY ANSWER: This is the first study to demonstrate that a PTGER2 antagonist can serve as an effective non-hormonal contraceptive in primates. WHAT IS KNOWN ALREADY: The requirement for PGE2 in ovulation and the release of an oocyte surrounded by expanded cumulus cells (cumulus-oocyte expansion; C-OE) was established through the generation of PTGS2 and PTGER2 null-mutant mice...
July 2014: Human Reproduction
Ozlem Sagir, Fatma Bahar Sunay, Hatice Yildirim, Elif Aksoz, Sabri Ozaslan, Ahmet Koroglu, Tugsen Aydemir, Ali Engin Ulusal, Feray Kockar
BACKGROUND & OBJECTIVES: Intra-articular (ia) injections of local anaesthetics and non-steroidal anti-inflammatory drugs (NSAID's) are simple and efficient to ensure post-operative analgesia but some of these have toxic effects on the synovium and cartilage. Dexketoprofen is recently introduced S-enantiomer of ketoprofen with a better analgesic and side effect profile. This study was done to evaluate the possible toxic effects of dexketoprofen trometamol on knee joint cartilage and symovium in vitro and in vivo...
December 2013: Indian Journal of Medical Research
Igor B Resnick, Claudine Barkats, Michael Y Shapira, Polina Stepensky, Allan I Bloom, Avichai Shimoni, David Mankuta, Nira Varda-Bloom, Lyudmila Rheingold, Moshe Yeshurun, Bella Bielorai, Amos Toren, Tsila Zuckerman, Arnon Nagler, Reuven Or
BACKGROUND: Several studies revealed that MSC from human bone marrow can downregulate graft-versus-host disease (GVHD) after allogeneic HSCT. METHODS: Herein we present 50 patients with acute GVHD who got 74 (1-4) MSC infusions for 54 separate episodes of aGVHD. RESULTS: aGVHD was defined as steroid resistant grade IV aGVHD in 42 cases. The major presentation was gastrointestinal GVHD; two (n=18) or more (n=21) systems were involved in the majority of cases...
2013: American Journal of Blood Research
Young-Jin Joo, Se-Jin Yoon, Chang-Won Kim, Jung-Hwan Lee, Young-Jin Kim, Jung-Hoi Koo, Sun-Hong Song
OBJECTIVE: To evaluate the short-term clinical effects of the intra-articular injection of botulinum toxin type A (BoNT-A) for the treatment of adhesive capsulitis. METHODS: A prospective, controlled trial compared the effects of intra-articular BoNT-A (Dysport; 200 IU, n=15) with the steroid triamcinolone acetate (TA; 20 mg, n=13) in patients suffering from adhesive capsulitis of the shoulder. All patients were evaluated using a Numeric Rating Scale (NRS) of the pain intensity and a measurement of the range of motion (ROM) at baseline (before treatment) and at 2, 4, and 8 weeks post-treatment...
April 2013: Annals of Rehabilitation Medicine
Hirohito Mori, Shintaro Fujihara, Noriko Nishiyama, Hideki Kobara, Makoto Oryu, Kiyohito Kato, Kazi Rafiq, Tsutomu Masaki
The local injection of triamcinolone acetonide (TA) is effective in preventing pyloric stenosis and deformity following large endoscopic submucosal dissection (ESD). However, because of its long-acting nature, TA can induce long-term local immunosuppression and subsequent adverse events. We report a case of a cytomegalovirus (CMV) ulcer that formed only at the TA local injection site. A 68-year-old man underwent ESD to treat early gastric cancer that formed over the pylorus. The lesion extended to the duodenum, and an artificial ulcer covered more than two-thirds of the circumference of the pylorus...
February 21, 2013: World Journal of Gastroenterology: WJG
Harsha Shanthanna, Philip Chan, James McChesney, James Paul, Lehana Thabane
BACKGROUND: Chronic lumbar radicular pain can be described as neuropathic pain along the distribution of a particular nerve root. The dorsal root ganglion has been implicated in its pathogenesis by giving rise to abnormal impulse generation as a result of irritation, direct compression and sensitization. Chronic lumbar radicular pain is commonly treated with medications, physiotherapy and epidural steroid injections. Epidural steroid injections are associated with several common and rarer side effects such as spinal cord infarction and death...
April 28, 2012: Trials
Gyu-Sik Choi, Sang-Ho Ahn, Yun-Woo Cho, Dong-Kyu Lee
OBJECTIVE: To evaluate the short-term effectiveness of pulsed radiofrequency on the dorsal root ganglion (DRG) in patients with chronic refractory cervical radicular pain. METHOD: Fifteen patients (13 males, 2 females; mean age, 55.9 years) with chronic radicular pain due to cervical disc herniation or foraminal stenosis refractory to active rehabilitative management, including transforaminal cervical epidural steroid injection and exercise, were selected. All patients received pulsed radiofrequency on the symptomatic cervical dorsal root ganglion and were carefully evaluated for neurologic deficits and side effects...
December 2011: Annals of Rehabilitation Medicine
Hong-Zhao Lei, Bin Sun, Da-Kan Liu, Xiao-Nan Guo, Yu-Chun Ma, Jun-Bo Qiao, Chang-Xian Dong
OBJECTIVE: To review and summarize the clinical characteristics and therapeutic approaches of Kasabach-Merritt syndrome (KMS). METHODS: The combined and sequential therapy was used to for 51 KMS infants between 2005 and 2009. And all cases were retrospectively analyzed. There were 27 males and 24 females with a median age of 1.8 months (range: 2 days to 2.5 years). Among them, lesions were located in maxillofacial (n = 20), truck (n = 4), upper extremities (n = 11) and lower extremities (n = 16)...
September 27, 2011: Zhonghua Yi Xue za Zhi [Chinese medical journal]
J G LeHoux, A Tremblay
We studied the effect of alterations in the intake of sodium and potassium as well as changes in circulating adrenocorticotropin (ACTH) on the expression of the two rate-limiting systems of aldosterone formation in the rat. Low sodium and high potassium intake promoted time-dependent increases in the zona glomerulosa cytochrome P450scc (P450scc) and cytochrome P450c11 (P450c11) protein and mRNA levels, but no changes were found in the zona fasciculata-reticularis. In addition, these responses were associated with markedly elevated transcriptional activities...
December 1992: Journal of Steroid Biochemistry and Molecular Biology
Paola Devoto, Roberto Frau, Valentina Bini, Giuliano Pillolla, Pierluigi Saba, Giovanna Flore, Marta Corona, Francesco Marrosu, Marco Bortolato
Cogent evidence highlights a key role of neurosteroids and androgens in schizophrenia. We recently reported that inhibition of steroid 5α-reductase (5αR), the rate-limiting enzyme in neurosteroid synthesis and androgen metabolism, elicits antipsychotic-like effects in humans and animal models, without inducing extrapyramidal side effects. To elucidate the anatomical substrates mediating these effects, we investigated the contribution of peripheral and neural structures to the behavioral effects of the 5αR inhibitor finasteride (FIN) on the prepulse inhibition (PPI) of the acoustic startle reflex (ASR), a rat paradigm that dependably simulates the sensorimotor gating impairments observed in schizophrenia and other neuropsychiatric disorders...
October 2012: Psychoneuroendocrinology
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