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https://www.readbyqxmd.com/read/29177632/the-use-of-lumbar-epidural-injection-of-platelet-lysate-for-treatment-of-radicular-pain
#1
Christopher Centeno, Jason Markle, Ehren Dodson, Ian Stemper, Matthew Hyzy, Christopher Williams, Michael Freeman
BACKGROUND: Epidural steroid injections (ESI) are the most common pain management procedure performed in the US, however evidence of efficacy is limited. In addition, there is early evidence that the high dose of corticosteroids used can have systemic side effects. We describe the results of a case series evaluating the use of platelet lysate (PL) epidural injections for the treatment of lumbar radicular pain as an alternative to corticosteroids. METHODS: Registry data was obtained for patients (N = 470) treated with PL epidural injections presenting with symptoms of lumbar radicular pain and MRI findings that were consistent with symptoms...
November 25, 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28872378/intralesional-corticosteroid-injections-as-treatment-for-non-infectious-orbital-inflammation
#2
Sara Reggie, Michael Neimkin, John Holds
A retrospective single-center chart review identified 19 patients treated with intralesional corticosteroid injection between 2007 and 2015 for orbital inflammatory disease. Patients were treated in the office, or intraoperatively at the time of orbital exploration and biopsy, with 5-40 mg of triamcinolone acetonide. Average follow up time was 2.44 years. Information recorded included visual acuity and eyelid position measurements, pre-injection treatment, post-injection treatment, complications, and exam findings...
September 5, 2017: Orbit
https://www.readbyqxmd.com/read/28721298/hydrocortisone-relieves-the-immediate-post-operative-scrotal-edema-after-inguinal-varicocelectomy-a-prospective-clinical-trial
#3
Samir Elhanbly, Tamer Youssef, Ayman Elkholy, Mamdouh Abdel-Gawad, Taymour Mostafa
This study aimed to assess the effect of a single IM injection of hydrocortisone succinate in relieving the immediate post-varicocelectomy scrotal edema. In all, 117 patients with grades II and III varicocele who developed post-varicocelectomy scrotal edema were randomly classified into group A (n = 59) that received a single IM hydrocortisone sodium succinate injection plus ordinary post-operative treatment and Group B (n = 58), which received the post-operative treatment alone. All patients were followed up to assess; changes in scrotal edema, the day of return to work and emergence of complications...
July 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28226245/subconjunctival-injectable-dendrimer-dexamethasone-gel-for-the-treatment-of-corneal-inflammation
#4
Uri Soiberman, Siva P Kambhampati, Tony Wu, Manoj K Mishra, Yumin Oh, Rishi Sharma, Jiangxia Wang, Abdul Elah Al Towerki, Samuel Yiu, Walter J Stark, Rangaramanujam M Kannan
Corneal inflammation is often encountered as a key pathological event in many corneal diseases. Current treatments involve topical corticosteroids which require frequent instillations due to rapid tear turnover, causing side-effects such as corneal toxicity and elevated intraocular pressure (IOP). Hence, new interventions that can reduce side effects, dosing frequency, and increase patient compliance can be highly beneficial. In this study, we explore a subconjunctival injectable gel based on G4-PAMAM dendrimer and hyaluronic acid, cross-linked using thiol-ene click chemistry, incorporated with dendrimer dexamethasone (D-Dex) conjugates as a potential strategy for sustained delivery and enhanced bioavailability of corticosteroids...
May 2017: Biomaterials
https://www.readbyqxmd.com/read/28009689/a-comparison-of-gene-expression-of-decorin-and-mmp13-in-hypertrophic-scars-treated-with-calcium-channel-blocker-steroid-and-interferon-a-human-scar-carrying-animal-model-study
#5
COMPARATIVE STUDY
Shih-Yi Yang, Jui-Yung Yang, Yen-Chang Hsiao, Shiow-Shuh Chuang
BACKGROUND: The formation of hypertrophic scaring (HSc) is an abnormal wound-healing response. In a previous study, an animal model with human scar tissue implanted into nude mice (BALB/c) has been successfully established. The effects of verapamil as well as combination therapy with verapamil and kenacort have been studied and compared. OBJECTIVE: To treat persistent hypertrophic scars, local injection of drugs composed of steroids, calcium channel blockers (CCBs), and interferon might be a good method...
January 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/27550949/an-evidence-based-review-of-the-efficacy-of-perioperative-analgesic-techniques-for-breast-cancer-related-surgery
#6
Gloria S Cheng, Brian M Ilfeld
Objective: To review the published evidence regarding perioperative analgesic techniques for breast cancer-related surgery. Design: Topical review. Methods: Randomized, controlled trials (RCTs) were selected for inclusion in the review. Also included were large prospective series providing estimates of potential risks and technical reports and small case series demonstrating a new technique or approaches of interest to clinicians. Results: A total of 514 abstracts were reviewed, with 284 studies meeting criteria for full review...
July 1, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/26917068/visual-acuity-and-astigmatism-in-periocular-infantile-hemangiomas-treated-with-oral-beta-blocker-versus-intralesional-corticosteroid-injection
#7
COMPARATIVE STUDY
Erin P Herlihy, John P Kelly, Robert Sidbury, Jonathan A Perkins, Avery H Weiss
BACKGROUND: Periocular infantile hemangiomas (PIH) can induce anisometropic astigmatism, a risk factor for amblyopia. Oral beta-blocker therapy has largely supplanted systemic or intralesional corticosteroids. The purpose of this study was to evaluate the effect and time course of these treatment modalities on visual acuity and induced astigmatism. METHODS: The medical records of patients with PIH treated with oral propanolol between November 2008 and July 2013 were retrospectively reviewed for data on visual acuity and astigmatism...
February 2016: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/26000682/increased-dose-of-betamethasone-for-transforaminal-epidural-steroid-injections-is-not-associated-with-superior-pain-outcomes-at-4-weeks
#8
Waylan Wong, Dermot P Maher, Daniel Iyayi, Raul Lopez, Bahman Shamloo, Howard Rosner, Roya Yumul
BACKGROUND: Fluoroscopically guided transforaminal epidural steroid injections (FG-TFESIs) have been shown to provide both immediate and long-term improvement in patient's self-reported pain. Administration of the lowest possible dose of epidural betamethasone is desired to minimize side effects while maintaining efficacy. We hypothesize that a 3 mg or a 6 mg dose of betamethasone will demonstrate equivalent analgesic properties. OBJECTIVES: To compare the analgesic efficacy of 3 mg and a 6 mg dose of betamethasone for use in FG-TFESI...
May 2015: Pain Physician
https://www.readbyqxmd.com/read/25908253/meloxicam-prevents-cox-2-mediated-post-surgical-inflammation-but-not-pain-following-laparotomy-in-mice
#9
J V Roughan, H G M J Bertrand, H M Isles
BACKGROUND: Inflammation is thought to be a major contributor to post-surgical pain, so non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used analgesics. However, compared to rats, considerably less is known as to how successfully these prevent pain in mice. METHODS: A fluorescent COX-2 selective probe was used for the first time to evaluate the post-surgical anti-inflammatory effects of meloxicam, and automated behaviour analyses (HomeCageScan; HCS), the Mouse Grimace Scale (MGS) and body weight changes to assess its pain-preventative properties...
February 2016: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/25252488/extracorporeal-shock-wave-therapy-for-treatment-of-plantar-fasciitis
#10
Nabeel Dastgir
OBJECTIVE: To explore the effect of extracorporeal shock wave therapy in patients with chronic plantar faciitis. METHODS: The prospective study was conducted at Department of Orhopaedic, Regional Hospital, Limerick, Ireland from January to December 2004 and comprised 70 heels in 62 patients with chronic plantar fasciitis in whom conventional conservative treatment consisting of non-steroidal anti-inflammatory drugs, heel cup, orthoses and/or shoe modifications, local steroid injections had failed, and they were treated with low energy extracorporeal shock wave therapy...
June 2014: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/25242997/effect-of-lithium-chloride-on-the-luteal-steroidogenesis-in-gonadotropin-stimulated-rat
#11
Maryam Khodadadi, Shiva Basavaiah, Saeid Abediankenari
BACKGROUND: Main function of corpus luteum is progesterone synthesis that is significantly accompanied with an increase in levels of mRNA encoding of steroidogenic enzymes known as luteal markers. OBJECTIVE: This study was designed to evaluate effects of lithium chloride on the release of steroid hormones and steroidogenic enzymes in gonadotropin-stimulated rats. MATERIALS AND METHODS: Immature 23 days old Wistar rats were divided into 10 groups; each group comprised of 8 rats, and induced with single injection of pregnant mare's serum gonadotrophin (PMSG) and followed by single injection of human chorionic gonadotropin (hCG)...
May 2012: Iranian Journal of Reproductive Medicine
https://www.readbyqxmd.com/read/25209215/driving-reaction-times-in-patients-with-foot-and-ankle-pathology-before-and-after-image-guided-injection-pain-relief-without-improved-function
#12
Paul G Talusan, Christopher P Miller, Ameya V Save, John S Reach
BACKGROUND: Foot and ankle pathology is common in the driving population. Local anesthetic steroid injections are frequent ambulatory treatments. Brake reaction time (BRT) has validated importance in motor vehicle safety. There are no prior studies examining the effect of foot and ankle pathology and injection treatment on the safe operation of motor vehicles. We studied BRT in patients with foot and ankle musculoskeletal disease before and after image-guided injection treatment. METHODS: A total of 37 participants were enrolled...
April 2015: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/25078268/plasma-concentration-of-ketorolac-after-local-infiltration-analgesia-in-hip-arthroplasty
#13
F Affas, S Eksborg, P Wretenberg, C Olofsson, N Stephanson, C-O Stiller
BACKGROUND: Local infiltration analgesia (LIA) with local anaesthetic (ropivacaine), a nonsteroidal anti-inflammatory drug (ketorolac) and epinephrine after lower extremity arthroplasty has gained increasing popularity during the last decade. This method has certain advantages, which include minimal systemic side effects, faster post-operative mobilization, earlier post-operative discharge from hospital and less opioid consumption. However, information regarding plasma concentrations of ketorolac after LIA mixture is insufficient to predict the risk of renal impairment in patients subjected to arthroplasty...
October 2014: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/25054389/adverse-events-associated-with-fluoroscopically-guided-zygapophyseal-joint-injections
#14
Chris Plastaras, Zachary McCormick, Donald Macron, Cynthia Garvan, Anand Joshi, Gary Chimes, Wesley Smeal, Joshua Rittenberg
BACKGROUND: In spite of the widespread performance of intra-articular zygapophyseal joint (IAZJ) injections, we know of no systematic analysis to date that examines the risks and types of adverse events when IAZJ injections are performed. OBJECTIVE: To describe the type, incidence, and factors contributing to adverse events associated with fluoroscopically guided IAZJ injections. STUDY DESIGN: A retrospective, cohort study of English-speaking adults aged 18 - 90 years who underwent fluoroscopically guided IAZJ injections between March 8, 2004, and April 19, 2007...
July 2014: Pain Physician
https://www.readbyqxmd.com/read/24781425/a-prostaglandin-e2-receptor-antagonist-prevents-pregnancies-during-a-preclinical-contraceptive-trial-with-female-macaques
#15
M C Peluffo, J Stanley, N Braeuer, A Rotgeri, K-H Fritzemeier, U Fuhrmann, B Buchmann, T Adevai, M J Murphy, M B Zelinski, B Lindenthal, J D Hennebold, R L Stouffer
STUDY QUESTION: Can administration of a prostaglandin (PG) E2 receptor 2 (PTGER2) antagonist prevent pregnancy in adult female monkeys by blocking periovulatory events in the follicle without altering menstrual cyclicity or general health? SUMMARY ANSWER: This is the first study to demonstrate that a PTGER2 antagonist can serve as an effective non-hormonal contraceptive in primates. WHAT IS KNOWN ALREADY: The requirement for PGE2 in ovulation and the release of an oocyte surrounded by expanded cumulus cells (cumulus-oocyte expansion; C-OE) was established through the generation of PTGS2 and PTGER2 null-mutant mice...
July 2014: Human Reproduction
https://www.readbyqxmd.com/read/24521635/evaluation-of-the-effects-of-dexketoprofen-trometamol-on-knee-jo%C3%A4-nt-an-in-vivo-in-vitro-study
#16
Ozlem Sagir, Fatma Bahar Sunay, Hatice Yildirim, Elif Aksoz, Sabri Ozaslan, Ahmet Koroglu, Tugsen Aydemir, Ali Engin Ulusal, Feray Kockar
BACKGROUND & OBJECTIVES: Intra-articular (ia) injections of local anaesthetics and non-steroidal anti-inflammatory drugs (NSAID's) are simple and efficient to ensure post-operative analgesia but some of these have toxic effects on the synovium and cartilage. Dexketoprofen is recently introduced S-enantiomer of ketoprofen with a better analgesic and side effect profile. This study was done to evaluate the possible toxic effects of dexketoprofen trometamol on knee joint cartilage and symovium in vitro and in vivo...
December 2013: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/23997985/treatment-of-severe-steroid-resistant-acute-gvhd-with-mesenchymal-stromal-cells-msc
#17
Igor B Resnick, Claudine Barkats, Michael Y Shapira, Polina Stepensky, Allan I Bloom, Avichai Shimoni, David Mankuta, Nira Varda-Bloom, Lyudmila Rheingold, Moshe Yeshurun, Bella Bielorai, Amos Toren, Tsila Zuckerman, Arnon Nagler, Reuven Or
BACKGROUND: Several studies revealed that MSC from human bone marrow can downregulate graft-versus-host disease (GVHD) after allogeneic HSCT. METHODS: Herein we present 50 patients with acute GVHD who got 74 (1-4) MSC infusions for 54 separate episodes of aGVHD. RESULTS: aGVHD was defined as steroid resistant grade IV aGVHD in 42 cases. The major presentation was gastrointestinal GVHD; two (n=18) or more (n=21) systems were involved in the majority of cases...
2013: American Journal of Blood Research
https://www.readbyqxmd.com/read/23705115/a-comparison-of-the-short-term-effects-of-a-botulinum-toxin-type-a-and-triamcinolone-acetate-injection-on-adhesive-capsulitis-of-the-shoulder
#18
Young-Jin Joo, Se-Jin Yoon, Chang-Won Kim, Jung-Hwan Lee, Young-Jin Kim, Jung-Hoi Koo, Sun-Hong Song
OBJECTIVE: To evaluate the short-term clinical effects of the intra-articular injection of botulinum toxin type A (BoNT-A) for the treatment of adhesive capsulitis. METHODS: A prospective, controlled trial compared the effects of intra-articular BoNT-A (Dysport; 200 IU, n=15) with the steroid triamcinolone acetate (TA; 20 mg, n=13) in patients suffering from adhesive capsulitis of the shoulder. All patients were evaluated using a Numeric Rating Scale (NRS) of the pain intensity and a measurement of the range of motion (ROM) at baseline (before treatment) and at 2, 4, and 8 weeks post-treatment...
April 2013: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/23467493/cytomegalovirus-associated-gastric-ulcer-a-side-effect-of-steroid-injections-for-pyloric-stenosis
#19
Hirohito Mori, Shintaro Fujihara, Noriko Nishiyama, Hideki Kobara, Makoto Oryu, Kiyohito Kato, Kazi Rafiq, Tsutomu Masaki
The local injection of triamcinolone acetonide (TA) is effective in preventing pyloric stenosis and deformity following large endoscopic submucosal dissection (ESD). However, because of its long-acting nature, TA can induce long-term local immunosuppression and subsequent adverse events. We report a case of a cytomegalovirus (CMV) ulcer that formed only at the TA local injection site. A 68-year-old man underwent ESD to treat early gastric cancer that formed over the pylorus. The lesion extended to the duodenum, and an artificial ulcer covered more than two-thirds of the circumference of the pylorus...
February 21, 2013: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/22540851/assessing-the-effectiveness-of-pulse-radiofrequency-treatment-of-dorsal-root-ganglion-in-patients-with-chronic-lumbar-radicular-pain-study-protocol-for-a-randomized-control-trial
#20
RANDOMIZED CONTROLLED TRIAL
Harsha Shanthanna, Philip Chan, James McChesney, James Paul, Lehana Thabane
BACKGROUND: Chronic lumbar radicular pain can be described as neuropathic pain along the distribution of a particular nerve root. The dorsal root ganglion has been implicated in its pathogenesis by giving rise to abnormal impulse generation as a result of irritation, direct compression and sensitization. Chronic lumbar radicular pain is commonly treated with medications, physiotherapy and epidural steroid injections. Epidural steroid injections are associated with several common and rarer side effects such as spinal cord infarction and death...
April 28, 2012: Trials
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