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https://www.readbyqxmd.com/read/29720114/adverse-obstetric-and-neonatal-outcomes-complicated-by-psychosis-among-pregnant-women-in-the-united-states
#1
Qiu-Yue Zhong, Bizu Gelaye, Gregory L Fricchione, Paul Avillach, Elizabeth W Karlson, Michelle A Williams
BACKGROUND: Adverse obstetric and neonatal outcomes among women with psychosis, particularly affective psychosis, has rarely been studied at the population level. We aimed to assess the risk of adverse obstetric and neonatal outcomes among women with psychosis (schizophrenia, affective psychosis, and other psychoses). METHODS: From the 2007 - 2012 National (Nationwide) Inpatient Sample, 23,507,597 delivery hospitalizations were identified. From the same hospitalization, International Classification of Diseases diagnosis codes were used to identify maternal psychosis and outcomes...
May 2, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29695824/postpartum-psychiatric-disorders
#2
REVIEW
Samantha Meltzer-Brody, Louise M Howard, Veerle Bergink, Simone Vigod, Ian Jones, Trine Munk-Olsen, Simone Honikman, Jeannette Milgrom
Pregnancy is a complex and vulnerable period that presents a number of challenges to women, including the development of postpartum psychiatric disorders (PPDs). These disorders can include postpartum depression and anxiety, which are relatively common, and the rare but more severe postpartum psychosis. In addition, other PPDs can include obsessive-compulsive disorder, post-traumatic stress disorder and eating disorders. The aetiology of PPDs is a complex interaction of psychological, social and biological factors, in addition to genetic and environmental factors...
April 26, 2018: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/29621901/the-clinical-effectiveness-and-cost-effectiveness-of-lamotrigine-in-borderline-personality-disorder-a-randomized-placebo-controlled-trial
#3
Mike J Crawford, Rahil Sanatinia, Barbara Barrett, Gillian Cunningham, Oliver Dale, Poushali Ganguli, Geoff Lawrence-Smith, Verity Leeson, Fenella Lemonsky, Georgia Lykomitrou, Alan A Montgomery, Richard Morriss, Jasna Munjiza, Carol Paton, Iwona Skorodzien, Vineet Singh, Wei Tan, Peter Tyrer, Joseph G Reilly
OBJECTIVE: The authors examined whether lamotrigine is a clinically effective and cost-effective treatment for people with borderline personality disorder. METHOD: This was a multicenter, double-blind, placebo-controlled randomized trial. Between July 2013 and November 2016, the authors recruited 276 people age 18 or over who met diagnostic criteria for borderline personality disorder. Individuals with coexisting bipolar affective disorder or psychosis, those already taking a mood stabilizer, and women at risk of pregnancy were excluded...
April 6, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29380332/hyperlocomotion-test-for-assessing-behavioral-disorders
#4
Dan Ma, Paul C Guest
Under- or overfeeding during pregnancy can lead to behavioral deficits in the offspring in later life. Here, we present a protocol for setting up and carrying out the hyperlocomotion test for assessing behavioral symptoms such as psychosis or mania. As an example, we use the acute rat phencyclidine-injection model which exhibits hyperlocomotion and stereotypic behaviors, resembling the positive symptoms of schizophrenia.
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29019422/pharmacotherapy-of-mood-disorders-and-psychosis-in-pre-and-post-natal-women
#5
REVIEW
Beth Smith, Steven L Dubovsky
Untreated mood and psychotic disorders can have substantial adverse impacts on the patient, the fetus and the family, while treatment can ameliorate such problems. To address concerns by clinicians about the risks of psychotropic medications, this review addresses the risk/benefit analysis of somatic therapies for psychiatric disorders during pregnancy and lactation. Areas covered: All available research was reviewed on the impact on pregnancy and breastfeeding of mood and psychotic disorders, and of antidepressants, mood stabilizers, antipsychotic drugs, and electroconvulsive therapy...
November 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/28953852/prescription-of-sodium-valproate-as-a-mood-stabiliser-in-pregnancy
#6
Kate Womersley
This essay was submitted for the Royal College of Psychiatry's perinatal psychiatry medical student essay prize in 2017. The essay considers the choices available to women with bipolar disorder who become pregnant while taking sodium valproate to treat mania or for mood stabilisation. The implications of three options are considered: to stop all treatment, to switch to a different mood stabiliser or to continue on sodium valproate. The implications for the fetus, on the mother's wellbeing and the ethics of patient choice are discussed...
September 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28864703/admission-to-psychiatric-hospital-for-mental-illnesses-2-years-prechildbirth-and-postchildbirth-in-scotland-a-health-informatics-approach-to-assessing-mother-and-child-outcomes
#7
Julie Langan Martin, Gary McLean, Daniel Martin, Roch Cantwell, Daniel J Smith
OBJECTIVE: To identify factors associated with: admission to a specialist mother and baby unit (MBU) and the impact of perinatal mental illness on early childhood development using a data linkage approach in the 2 years prechildbirth and postchildbirth. METHODS: Scottish maternity records (SMR02) were linked to psychiatric hospital admissions (SMR04). 3290 pregnancy-related psychiatric admissions for 1730 women were assessed. To investigate factors associated with MBU admission, the group of mothers admitted to an MBU were compared with those admitted to general psychiatric wards...
September 1, 2017: BMJ Open
https://www.readbyqxmd.com/read/28841756/gastroschisis-in-europe-a-case-malformed-control-study-of-medication-and-maternal-illness-during-pregnancy-as-risk-factors
#8
Joanne E Given, Maria Loane, Ester Garne, Vera Nelen, Ingeborg Barisic, Hanitra Randrianaivo, Babak Khoshnood, Awi Wiesel, Anke Rissmann, Catherine Lynch, Amanda J Neville, Anna Pierini, Marian Bakker, Kari Klungsoyr, Anna Latos Bielenska, Clara Cavero-Carbonell, Marie-Claude Addor, Natalya Zymak-Zakutnya, David Tucker, Helen Dolk
BACKGROUND: Gastroschisis, a congenital anomaly of the abdomen, is associated with young maternal age and has increased in prevalence in many countries. Maternal illness and medication exposure are among environmental risk factors implicated in its aetiology. METHODS: A population-based case-malformed control study was conducted using data from 18 European congenital anomaly registries, with information on first trimester medication use, covering 8 million births 1995-2012...
November 2017: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/28805183/letter-to-the-editor-association-between-smoking-and-psychosis-may-be-mediated-by-maternal-smoking-during-pregnancy
#9
D Curtis
No abstract text is available yet for this article.
April 2018: Psychological Medicine
https://www.readbyqxmd.com/read/28798699/schizophrenia-or-atypical-lupus-erythematosus-with-predominant-psychiatric-manifestations-over-25%C3%A2-years-case-analysis-and-review
#10
Axel Mack, Christiane Pfeiffer, E Marion Schneider, Karl Bechter
We observed a case over 25 years of relapsing-remitting schizophrenic spectrum disorder, varying regarding the main symptomatology between more depressive or more schizoaffective or rather typical schizophrenic syndrome. Diseased phases were repeatedly accompanied by minor skin lesions, which were initially classified as mixed tissue disorder. Psychotic phases were waxing-waning over years. During one later relapse, skin involvement was severe, classified to likely represent an allergic reaction to psychopharmaca; this generalized exanthema remitted rapidly with cortisone treatment and azathioprine...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28771981/there-is-more-to-perinatal-mental-health-care-than-depression-public-health-nurses-reported-engagement-and-competence-in-perinatal-mental-health-care
#11
Agnes Higgins, Carmel Downes, Margaret Carroll, Ailish Gill, Mark Monahan
AIMS AND OBJECTIVES: To explore public health nurses' engagement, competence and education needs in relation to perinatal mental health care in Ireland. BACKGROUND: It is estimated that 15%-25% of women will experience a mental health problem during or postpregnancy, either as a new problem or a reoccurrence of a pre-existing problem. Public health nurses, or their equivalent, are ideally positioned to support women's mental health and improve health outcomes for the woman and baby, yet little is known about their role and engagement with mental health issues, other than with postnatal depression...
February 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28735583/fever-and-infections-during-pregnancy-and-psychosis-like-experiences-in-the-offspring-at-age-11-a-prospective-study-within-the-danish-national-birth-cohort
#12
J W Dreier, G Berg-Beckhoff, A M N Andersen, E Susser, M Nordentoft, K Strandberg-Larsen
BACKGROUND: Maternal exposures to fever and infections in pregnancy have been linked to subsequent psychiatric morbidity in the child. This study examined whether fever and common infections in pregnancy were associated with psychosis-like experiences (PLEs) in the child. METHODS: A longitudinal study of 46 184 children who participated in the 11-year follow-up of the Danish National Birth Cohort was conducted. Pregnant women were enrolled between 1996 and 2002 and information on fever, genitourinary infections, respiratory tract infection, and influenza-like illness during pregnancy was prospectively collected in two interviews during pregnancy...
February 2018: Psychological Medicine
https://www.readbyqxmd.com/read/28707502/appraisal-of-the-psychiatric-diagnostic-screening-questionnaire-in-a-perinatal-cohort-the-apron-study
#13
Brenda Leung, Nicole Letourneau, Katherine Bright, Gerald F Giesbrecht, Henry Ntanda, Lisa Gagnon
BACKGROUND: Depression and anxiety are routinely screened as part of perinatal care. However, other Axis 1 disorders and specific anxiety disorders are less likely to be screened or assessed as part of obstetric care. The objective of this study was to determine whether the Psychiatric Diagnostic Screening Questionnaire (PDSQ) is a potentially useful tool to screen for psychiatric conditions in pregnant and postpartum women in a community setting. METHODS: We compared the prevalence of DSM Axis I disorders obtained on the PDSQ with: (1) the prevalence of these disorders reported in previous studies of pregnant and postpartum women, and (2) scores obtained on the Edinburgh Postpartum Depression Scale (EPDS) and the Symptom Checklist-90-Revised (SCL-90R) anxiety scale...
August 2017: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/28704729/longitudinal-association-between-physical-activity-engagement-during-adolescence-and-mental-health-outcomes-in-young-adults-a-21-year-birth-cohort-study
#14
Shuichi Suetani, Abdullah Mamun, Gail M Williams, Jake M Najman, John J McGrath, James G Scott
OBJECTIVE: Previous studies provide mixed evidence that physical activity engagement (PAE) in adolescence is associated with later mental health outcomes. This study aimed to examine the association between PAE at age 14 and mental health outcomes at age 21 using a large birth cohort study. MATERIAL AND METHODS: Prospective data from the Mater-University of Queensland Study of Pregnancy, consisting of 3493 young adults, were analyzed. PAE at age 14 was estimated using self-report, and participants were categorized into; (1) frequent, (2) infrequent, or (3) no PAE group...
July 1, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28665012/prescribing-trends-and-indications-of-antipsychotic-medication-in-hong-kong-from-2004-to-2014-general-and-vulnerable-patient-groups
#15
Kim S J Lao, Anthony W Y Tam, Ian C K Wong, Frank M C Besag, Kenneth K C Man, Celine S L Chui, Esther W Chan
PURPOSE: Antipsychotic-prescribing patterns remain unclear in Asia. The aims of our study were to investigate prescribing trends of antipsychotic medication in the general population, children, and older patients by drug generation (first or second), the prescribing trend in pregnant women, the probable indication for antipsychotic prescription, and the prescribing trend by dosage form. METHODS: This descriptive study identified and included all patients prescribed with antipsychotic in Hong Kong from 2004 to 2014 using the Clinical Data Analysis and Report System...
June 30, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28629296/atypical-antipsychotic-use-and-outcomes-in-an-urban-maternal-mental-health-service
#16
Susan Hatters Friedman, Charmian Moller-Olsen, Chandni Prakash, Abigail North
Objective Despite many women suffering from psychosis in their childbearing years, limited data exist about the use of atypical antipsychotic agents in pregnancy. Atypical antipsychotic agents are often used to treat bipolar disorder, instead of lithium or valproate because of the known teratogenicity of those agents. As well, atypical antipsychotics are often prescribed in anxiety disorders and depression. This study sought to describe pregnancy outcomes for women prescribed atypical antipsychotics during pregnancy...
August 2016: International Journal of Psychiatry in Medicine
https://www.readbyqxmd.com/read/28620812/case-study-of-first-episode-schizophrenia-in-pregnancy-and-postpartum
#17
Kristopher A Kast, Smita Agarkar
Patients with first-episode psychosis of peripartum onset commonly prove to have a mood-disorder diathesis; however, a proportion of cases represent first-episode schizophrenia. We present such a case and discuss the clinical relevance of recognizing this small but important population of new mothers. These patients are at considerable risk of misdiagnosis, resulting in ineffective maintenance therapy, poorer recovery of function, and development of treatment resistance. Accurate diagnosis in the peripartum period will impact treatment decisions and long-term therapy...
August 2017: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/28588894/aetiological-pathways-to-borderline-personality-disorder-symptoms-in-early-adolescence-childhood-dysregulated-behaviour-maladaptive-parenting-and-bully-victimisation
#18
Catherine Winsper, James Hall, Vicky Y Strauss, Dieter Wolke
BACKGROUND: Developmental theories for the aetiology of Borderline Personality Disorder (BPD) suggest that both individual features (e.g., childhood dysregulated behaviour) and negative environmental experiences (e.g., maladaptive parenting, peer victimisation) may lead to the development of BPD symptoms during adolescence. Few prospective studies have examined potential aetiological pathways involving these two factors. METHOD: We addressed this gap in the literature using data from the Avon Longitudinal Study of Parents and Children (ALSPAC)...
2017: Borderline Personality Disorder and Emotion Dysregulation
https://www.readbyqxmd.com/read/28572274/caspr2-autoantibodies-are-raised-during-pregnancy-in-mothers-of-children-with-mental-retardation-and-disorders-of-psychological-development-but-not-autism
#19
Ester Coutinho, Leslie Jacobson, Marianne Giørtz Pedersen, Michael Eriksen Benros, Bent Nørgaard-Pedersen, Preben Bo Mortensen, Paul J Harrison, Angela Vincent
BACKGROUND, METHODS AND OBJECTIVES: Maternal autoantibodies to neuronal proteins may be one cause of neurodevelopmental disorders. This exploratory study used the Danish archived midgestational sera and their nationwide registers to search for antibodies to the N-methyl-D-aspartate receptor (NMDAR) and contactin-associated protein-like 2 (CASPR2) in maternal sera, and to relate them to subsequent psychiatric diagnoses in the woman or her child. RESULTS: In a sample of 192 women, there was no association between antibody status and subsequent psychosis in the mothers...
September 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28480579/longitudinal-epigenetic-predictors-of-amygdala-hippocampus-volume-ratio
#20
Esther Walton, Charlotte A M Cecil, Matthew Suderman, Jingyu Liu, Jessica A Turner, Vince Calhoun, Stefan Ehrlich, Caroline L Relton, Edward D Barker
BACKGROUND: The ratio between amygdala:hippocampal (AH) volume has been associated with multiple psychiatric problems, including anxiety and aggression. Yet, little is known about its biological underpinnings. Here, we used a methylome-wide approach to test (a) whether DNA methylation in early life (birth, age 7) prospectively associates with total AH volume ratio in early adulthood, and (b) whether significant DNA methylation markers are influenced by prenatal risk factors. METHODS: Analyses were based on a subsample (n = 109 males) from the Avon Longitudinal Study of Parents and Children, which included measures of prenatal risk, DNA methylation (Infinium Illumina 450k), T1-weighted brain scans and psychopathology in early adulthood (age 18-21)...
December 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
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