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Vitamin C AND ET-1

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https://www.readbyqxmd.com/read/27905067/mathematical-model-of-bone-remodeling-captures-the-antiresorptive-and-anabolic-actions-of-various-therapies
#1
David S Ross, Khamir Mehta, Antonio Cabal
A better understanding of the molecular pathways regulating the bone remodeling process should help in the development of new antiresorptive regulators and anabolic regulators, that is, regulators of bone resorption and of bone formation. Understanding the mechanisms by which parathyroid hormone (PTH) influences bone formation and how it switches from anabolic to catabolic action is important for treating osteoporosis (Poole and Reeve in Curr Opin Pharmacol 5:612-617, 2005). In this paper we describe a mathematical model of bone remodeling that incorporates, extends, and integrates several models of particular aspects of this biochemical system (Cabal et al...
November 30, 2016: Bulletin of Mathematical Biology
https://www.readbyqxmd.com/read/27903510/vitamin-d-supplementation-reduces-some-at1-aa-induced-downstream-targets-implicated-in-preeclampsia-including-hypertension
#2
Jessica L Faulkner, Lorena M Amaral, Denise C Cornelius, Mark W Cunningham, Tarek Ibrahim, Autumn Heep, Nathan Campbell, Nathan Usry, Kedra Wallace, Florian Herse, Ralf Dechend, Babbette D LaMarca
Autoantibodies to the angiotensin II (ANGII) type I receptor (AT1-AA) are associated with preeclampsia (PE). We found that Vitamin D supplementation reduced AT1-AA and blood pressure (MAP) in the RUPP rat model of PE. However, it was undetermined if the decrease in AT1-AA was the mechanism whereby Vitamin D lowered MAP or if it was through factors downstream of AT1-AA. Uterine artery resistance index, placental ET-1 and sFlt-1 are increased with AT1-AA induced hypertension and considered markers of PE in pregnant women...
November 30, 2016: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/27323139/active-vitamin-d3-1-25-oh-2d3-protects-against-macrovasculopathy-in-a-rat-model-of-type-2-diabetes-mellitus
#3
R Ma, X L Deng, G L Du, C Li, S Xiao, Y Aibibai, J Zhu
To investigate the protective effect of the active form of vitamin D3, 1,25-(OH)2D3, on macrovasculopathy in rats with type 2 diabetes mellitus (T2DM), 8-week-old male Sprague-Dawley rats were randomly divided into control group, T2DM group, and treatment group. The T2DM model was established after 6 weeks by administering an intraperitoneal injection of streptozotocin (30 mg/kg). 1,25-(OH)2D3 was administered by gavage to rats in the treatment group, and an equal volume of peanut oil was administered to rats in the T2DM group...
2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27278776/erosive-potential-of-vitamin-and-vitamin-mineral-effervescent-tablets
#4
COMPARATIVE STUDY
Florian J Wegehaupt, Nancy Lunghi, Vanessa M G Hogger, Thomas Attin
The extrinsic sources for erosion-causing acids are primarily acidic beverages and foodstuffs. Effervescent tablets also contain organic acids (e.g. citric, tartaric, malic) in order to form carbon dioxide by contact with water – with the help of the carbonate salts of the tablets. To adequately inform patients about the possible erosive potential of effervescent tablets, this study was undertaken in order to investigate the erosive potential of effervescent tablets (ET), containing either a combination of vitamins and minerals or vitamins only, commercially available in Switzerland...
2016: Swiss Dental Journal
https://www.readbyqxmd.com/read/26915194/-irrigation-scheduling-with-a-20-cm-standard-pan-for-drip-irrigated-cucumber-grown-in-solar-greenhouse-in-the-north-china-plain
#5
Xue-wen Gong, Jing-sheng Sun, Hao Liu, Hao Zhang, Xiao-lei Wu, Yu-hong Sun
An experiment was conducted in 2013 and 2014 at the Xinxiang Comprehensive Experimental Station, Chinese Academy of Agriculture Sciences. Water amount was estimated with the Ep-20 and pan coefficient. Responses of cucumber evapotranspiration (ET), yield, quality and water use efficiency (WUE) to different drip irrigation amounts (Kcp1: 0.25; Kcp2: 0.5; Kcp3: 0.75; Kcp4: 1.0; Kcp5: 1.25) were investigated. The possibility of developing drip irrigation scheduling using the 20 cm pan was also discussed. Results showed that the seasonal evapotranspiration of cucumber ranged between 129 and 314 mm, and the water consumption generally increased with the increase in drip irrigation water amount...
November 2015: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
https://www.readbyqxmd.com/read/26908145/effects-of-grape-pomace-in-growing-lamb-diets-compared-with-vitamin-e-and-grape-seed-extract-on-meat-shelf-life
#6
C Guerra-Rivas, C Vieira, B Rubio, B Martínez, B Gallardo, A R Mantecón, P Lavín, T Manso
The effect of dietary treatment (CTRL, control; VIT-E, 500 mg kg(-1) vitamin E; GSE, 50 mg grape seed extract kg(-1); GP-5, 5% dried red grape pomace kg(-1)) on shelf life of lamb meat was studied. After slaughter (27 kg LBW), m. longissimus thoracis et lumborum was sliced, packaged under modified atmosphere (80:20%/O2:CO2) and stored in retail conditions for 14 days. At each sampling day (0, 4, 7, 11, 14), microbiological, physico-chemical and sensory characteristics were analysed. Meat from VIT-E presented lower microbial counts than CTRL, GSE and GP-5, without differences between polyphenol treatments (GSE and GP-5) and CTRL...
June 2016: Meat Science
https://www.readbyqxmd.com/read/26877382/p-080-nutritional-status-and-diet-in-west-algerian-scholar-children
#7
B Mahmoudi, R Sahnoune, M Bouchenak
OBJECTIFS: La surveillance de l'état nutritionnel et la promotion d'une alimentation optimale sont des éléments essentiels des soins de santé de tous les enfants. L'objectif de notre travail est l'évaluation de l'état nutritionnel et l'estimation de la consommation alimentaire chez des enfants scolarisés à Oran. MéTHODES: Le poids et la taille sont mesurés auprès de 464 élèves, âgés entre 6 et 10 ans (F/G=252/212). Les seuils de l'Indice de Masse Corporelle (IMC) établis par l'IOTF et le PNNS ont été utilisés pour évaluer le statut pondéral des enfants...
December 2015: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/26856587/the-national-osteoporosis-foundation-s-position-statement-on-peak-bone-mass-development-and-lifestyle-factors-a-systematic-review-and-implementation-recommendations
#8
C M Weaver, C M Gordon, K F Janz, H J Kalkwarf, J M Lappe, R Lewis, M O'Karma, T C Wallace, B S Zemel
Lifestyle choices influence 20-40 % of adult peak bone mass. Therefore, optimization of lifestyle factors known to influence peak bone mass and strength is an important strategy aimed at reducing risk of osteoporosis or low bone mass later in life. The National Osteoporosis Foundation has issued this scientific statement to provide evidence-based guidance and a national implementation strategy for the purpose of helping individuals achieve maximal peak bone mass early in life. In this scientific statement, we (1) report the results of an evidence-based review of the literature since 2000 on factors that influence achieving the full genetic potential for skeletal mass; (2) recommend lifestyle choices that promote maximal bone health throughout the lifespan; (3) outline a research agenda to address current gaps; and (4) identify implementation strategies...
April 2016: Osteoporosis International
https://www.readbyqxmd.com/read/26102946/6d-06-vitamin-d-deficiency-and-endothelial-dysfunction-in-rheumatoid-arthritis-patients
#9
M Struglia, C A Stamerra, P Di Giosia, P Giorgini, C Capanna, D Grassi, G Properzi, C Ferri
OBJECTIVE: Vitamin D deficiency is commonly associated with rheumatoid arthritis (RA), with an inverse correlation between Disease Activity Score (DAS28) and Health Assessment Questionnaire (HAQ). Vitamin D is known to have a systemic anti-inflammatory action. We aimed to evaluate the effects of vitamin D supplementation on biomarkers of inflammation and endothelial activation [high sensitivity C- reactive protein (hs-CRP) and endothelin-1 (ET-1)], flow mediated dilation (FMD) in patients with RA...
June 2015: Journal of Hypertension
https://www.readbyqxmd.com/read/25803078/the-contribution-of-methionine-to-the-stability-of-the-escherichia-coli-metniq-abc-transporter-substrate-binding-protein-complex
#10
Phong T Nguyen, Qi Wen Li, Neena S Kadaba, Jeffrey Y Lai, Janet G Yang, Douglas C Rees
Despite the ubiquitous role of ATP-binding cassette (ABC) importers in nutrient uptake, only the Escherichia coli maltose and vitamin B12 ABC transporters have been structurally characterized in multiple conformations relevant to the alternating access transport mechanism. To complement our previous structure determination of the E. coli MetNI methionine importer in the inward facing conformation (Kadaba et al. (2008) Science 321, 250-253), we have explored conditions stabilizing the outward facing conformation...
September 2015: Biological Chemistry
https://www.readbyqxmd.com/read/25656533/comparison-of-methods-to-account-for-implausible-reporting-of-energy-intake-in-epidemiologic-studies
#11
COMPARATIVE STUDY
Jinnie J Rhee, Laura Sampson, Eunyoung Cho, Michael D Hughes, Frank B Hu, Walter C Willett
In a recent article in the American Journal of Epidemiology by Mendez et al. (Am J Epidemiol. 2011;173(4):448-458), the use of alternative approaches to the exclusion of implausible energy intakes led to significantly different cross-sectional associations between diet and body mass index (BMI), whereas the use of a simpler recommended criteria (<500 and >3,500 kcal/day) yielded no meaningful change. However, these findings might have been due to exclusions made based on weight, a primary determinant of BMI...
February 15, 2015: American Journal of Epidemiology
https://www.readbyqxmd.com/read/25651444/overall-and-abdominal-adiposity-in-midlife-and-subsequent-cognitive-function
#12
E Kesse-Guyot, V A Andreeva, M Touvier, C Jeandel, M Ferry, S Hercberg, P Galan
OBJECTIVES: The scientific literature supports a link between midlife adiposity and cognitive function or decline but most studies to-date have investigated only overall adiposity, often omitting important confounders from the analyses. We investigated in a cross-time design the relationships between two different midlife adiposity markers and subsequent cognitive function, testing midlife dietary patterns as a potential confounder of the associations. DESIGN: The study was based on the «Supplémentation en Vitamines et Minéraux Antioxydants» randomized trial (SU...
February 2015: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/25532375/-clinical-characteristics-and-combined-use-of-medicine-analysis-of-2-991-hospitalized-patients-with-psoriasis-based-on-real-world-database
#13
Jian-hong Li, Zhi-fei Wang, Yan-ming Xie, Wei Zhao
To analyze the clinical characteristics and combined use of chemical and traditional Chinese medicine (TCM) medicine of hospitalized patients with psoriasis base on real world database, 2 991 cases of hospitalized patients with psoriasis in hospital information system (HIS) database from 16 hospitals in China were analyzed for general hospitalization information, combined diseases and combined use of drugs et al. The results showed that half of inpatients aged 18-45 years old. The most common syndrome of TCM was intrinsic blood heat...
September 2014: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/25523296/association-between-arterial-stiffness-and-skin-microvascular-function-the-suvimax2-study-and-the-maastricht-study
#14
Thomas T van Sloten, Sébastien Czernichow, Alfons J Houben, Athanase D Protogerou, Ronald M Henry, Dennis M Muris, Miranda T Schram, Simone J Sep, Pieter C Dagnelie, Carla J van der Kallen, Nicolaas C Schaper, Jacques Blacher, Serge Hercberg, Bernard I Levy, Coen D Stehouwer
BACKGROUND: It has been hypothesized that arterial stiffness leads to generalized microvascular dysfunction and that individuals with type 2 diabetes mellitus (T2DM) are particularly prone to the detrimental effects of arterial stiffness. However, evidence for an association between stiffness and markers of generalized microvascular dysfunction is lacking. We therefore investigated the association between arterial stiffness and skin microvascular function in individuals without and with T2DM...
July 2015: American Journal of Hypertension
https://www.readbyqxmd.com/read/25351879/hanstruepera-neustonica-gen-nov-sp-nov-a-zeaxanthin-producing-member-of-the-family-flavobacteriaceae-isolated-from-estuarine-water-and-emendation-of-sediminibacter-furfurosus-khan-et-al-2007-emend-kwon-et-al-2014-mangrovimonas-yunxiaonensis-li-et-al-2013-antarcticimonas
#15
Asif Hameed, Mariyam Shahina, Wei-An Lai, Shih-Yao Lin, You-Cheng Liu, Yi-Han Hsu, Chiu-Chung Young
A Gram-staining-negative, strictly aerobic, yellowish-orange, flexirubin-positive, rod-shaped, non-flagellated, non-spore-forming and non-gliding marine bacterium, designated strain CC-PY-50(T), was isolated from estuarine water off Pingtung, Taiwan. The strain produced zeaxanthin as a major carotenoid pigment, and showed highest pairwise 16S rRNA gene sequence similarity to Bizionia hallyeonensis T-y7(T) (93.9 %) followed by Corallibacter vietnamensis KMM 6217(T) (93.8 %), Geojedonia litorea YCS-16(T) (93...
February 2015: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/25304103/conditionally-immortalized-human-pancreatic-stellate-cell-lines-demonstrate-enhanced-proliferation-and-migration-in-response-to-igf-i
#16
Ann H Rosendahl, Chinmay Gundewar, Katarzyna Said Hilmersson, Lan Ni, Moin A Saleem, Roland Andersson
Pancreatic stellate cells (PSCs) play a key role in the dense desmoplastic stroma associated with pancreatic ductal adenocarcinoma. Studies on human PSCs have been minimal due to difficulty in maintaining primary PSC in culture. We have generated the first conditionally immortalized human non-tumor (NPSC) and tumor-derived (TPSC) pancreatic stellate cells via transformation with the temperature-sensitive SV40 large T antigen and human telomerase (hTERT). These cells proliferate at 33°C. After transfer to 37°C, the SV40LT is switched off and the cells regain their primary PSC phenotype and growth characteristics...
January 15, 2015: Experimental Cell Research
https://www.readbyqxmd.com/read/25227305/robotic-total-thyroidectomy-with-modified-radical-neck-dissection-via-unilateral-retroauricular-approach
#17
Hyung Kwon Byeon, F Christopher Holsinger, Ralph P Tufano, Hyo Jin Chung, Won Shik Kim, Yoon Woo Koh, Eun Chang Choi
BACKGROUND: Traditionally, total thyroidectomy was performed through an open transcervical incision; in cases where there was evident nodal metastasis, the conventional surgical approach was to extend the incision into a large single transverse incision to complete the required neck dissection. However, recent innovation in the surgical technique of thyroidectomy has offered the opportunity to reduce the patient's burden from these prominent surgical scars in the neck. Minimally invasive surgical techniques have been developed and applied by many institutions worldwide, and more recently, various techniques of remote access surgery have been suggested and actively applied...
November 2014: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/25079761/endothelin-1-levels-and-biomarkers-of-oxidative-stress-in-glaucoma-patients
#18
N López-Riquelme, C Villalba, C Tormo, A Belmonte, C Fernandez, G Torralba, F Hernández
To investigate the levels of endothelin-1 (ET-1), homocysteine (Hcy), vitamins A, E, B12 and folic acid in plasma of patients with different types of glaucoma: primary open-angle glaucoma (POAG) and normotensive glaucoma (NTG). Patients were classified into 3 groups: group POAG comprised 48 patients, group NTG comprised 15 patients, and control group that comprised 75 healthy subjects. ET-1 levels were measured by ELISA, Vitamins A and E by HPLC, and Vitamin B12, homocysteine, and folic acid levels were determined by chemiluminescent immunoassay...
August 2015: International Ophthalmology
https://www.readbyqxmd.com/read/24976907/essential-hypertension-and-oxidative-stress-new-insights
#19
REVIEW
Jaime González, Nicolás Valls, Roberto Brito, Ramón Rodrigo
Essential hypertension is a highly prevalent pathological condition that is considered as one of the most relevant cardiovascular risk factors and is an important cause of morbidity and mortality around the world. Despite the fact that mechanisms underlying hypertension are not yet fully elucidated, a large amount of evidence shows that oxidative stress plays a central role in its pathophysiology. Oxidative stress can be defined as an imbalance between oxidant agents, such as superoxide anion, and antioxidant molecules, and leads to a decrease in nitric oxide bioavailability, which is the main factor responsible for maintaining the vascular tone...
June 26, 2014: World Journal of Cardiology
https://www.readbyqxmd.com/read/24944338/actinophytocola-gilvus-sp-nov-isolated-from-desert-soil-crusts-and-emended-description-of-the-genus-actinophytocola-indananda-et-al-2010
#20
Hong-Min Sun, Tao Zhang, Li-Yan Yu, Xin-Xin Lu, Xiao-Zhen Mou, Yu-Qin Zhang
An actinomycete strain, designated I12A-02593(T), was isolated from a desert soil crust sample collected in the Shapotou region of Tengger Desert, north-west China. The isolate grew well on International Streptomyces Project (ISP) media 2, 3, 5 and 7, YS and Bennett's agar; it produced spherical bodies and formed clumps on the aerial mycelia on ISP 5 agar plates. Chemotaxonomically, the strain contained meso-diaminopimelic acid as the diagnostic diamino acid, arabinose and galactose as the diagnostic sugars in whole-cell hydrolysates, MK-9(H4) as the sole isoprenoid quinone, and iso-C16 : 0, iso-C16 : 0 2-OH and iso-C16 : 1 H as the major cellular fatty acids, without mycolic acids...
September 2014: International Journal of Systematic and Evolutionary Microbiology
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