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Vitamin C AND ET-1

Alexander Valerevich Kryukov, Dmitry Alekseevich Sychev, Denis Anatolevich Andreev, Kristina Anatolievna Ryzhikova, Elena Anatolievna Grishina, Anastasia Vladislavovna Ryabova, Mark Alekseevich Loskutnikov, Valeriy Valerevich Smirnov, Olga Dmitrievna Konova, Irina Andreevna Matsneva, Pavel Olegovich Bochkov
Introduction: Difficulties in non-vitamin K anticoagulant (NOAC) administration in acute stroke can be associated with changes in pharmacokinetic parameters of NOAC such as biotransformation, distribution, and excretion. Therefore, obtaining data on pharmacokinetics of NOAC and factors that affect it may help develop algorithms for personalized use of this drug class in patients with acute cardioembolic stroke. Patients and methods: Pharmacokinetics of apixaban in patients with acute stroke was studied earlier by Kryukov et al...
2018: Pharmacogenomics and Personalized Medicine
Karen E Assmann, Moufidath Adjibade, Nitin Shivappa, James R Hébert, Michael D Wirth, Mathilde Touvier, Tasnime Akbaraly, Serge Hercberg, Pilar Galan, Chantal Julia, Emmanuelle Kesse-Guyot
Background: While low-grade chronic inflammation has been suggested as a major modulator of healthy aging (HA), no study has yet investigated the link between the inflammatory potential of the diet and multidimensional concepts of HA. Objective: We aimed to evaluate the association between the inflammatory potential of the diet at midlife, as measured by the Dietary Inflammatory Index (DII), and HA assessed 13 y later. Methods: We analyzed data from 2796 participants in the French Supplémentation en Vitamines et Minéraux Antioxydants (SU...
March 1, 2018: Journal of Nutrition
M Gelli, M A Allard, O Farges, C Paugam-Burtz, J Y Mabrut, J M Regimbeau, E Vibert, E Boleslawski
BACKGROUND: The operative risk of hepatectomy under antiplatelet therapy is unknown. This study sought to assess the outcomes of elective hepatectomy performed with or without aspirin continuation in a well balanced matched cohort. METHODS: Data were retrieved from a multicentre prospective observational study. Aspirin and control groups were compared by non-standardized methods and by propensity score (PS) matching analysis. The main outcome was severe (Dindo-Clavien grade IIIa or more) haemorrhage...
March 2018: British Journal of Surgery
Rena C Moon, Lori Gaskins, Andre F Teixeira, Muhammad A Jawad
BACKGROUND: Single-anastomosis duodenal switch (DS) was introduced by Sanchez-Pernaute et al. as a modification of the biliopancreatic diversion with duodenal switch. We have published preliminary results of the loop DS as the first report of the procedure in the USA. This study aims to evaluate the loop DS procedures again, in terms of weight loss, comorbidity resolution, complication rate, and address the nutritional concerns. METHODS: A retrospective chart review was performed on initial 128 patients who underwent laparoscopic or robot-assisted laparoscopic single-stage loop DS between December 17, 2013 and September 23, 2016...
December 22, 2017: Obesity Surgery
Christopher Stoffels, Mhmd Oumari, Aris Perrou, Andreas Termath, Waldemar Schlundt, Hans-Günther Schmalz, Mathias Schäfer, Vera Wewer, Sabine Metzger, Edgar Schömig, Dirk Gründemann
The candidate vitamin ergothioneine (ET), an imidazole-2-thione derivative of histidine betaine, is generally considered an antioxidant. However, the precise physiological role of ET is still unresolved. Here, we investigated in vitro the hypothesis that ET serves specifically to eradicate noxious singlet oxygen ((1)O2). Pure (1)O2 was generated by thermolysis at 37°C of N,N'-di(2,3-dihydroxypropyl)-1,4-naphthalenedipropanamide 1,4-endoperoxide (DHPNO2). Assays of DHPNO2 with ET or hercynine (= ET minus sulfur) at pH 7...
October 23, 2017: Free Radical Biology & Medicine
Gry Freja Skovsted, Pernille Tveden-Nyborg, Maiken Marie Lindblad, Stine Normann Hansen, Jens Lykkesfeldt
Vitamin C (vitC) deficiency is associated with increased cardiovascular disease risk, but its specific interplay with arteriolar function is unclear. This study investigates the effect of vitC deficiency in guinea pigs on plasma biopterin status and the vasomotor responses in coronary arteries exposed to vasoconstrictor/-dilator agents. Dunkin Hartley female guinea pigs (n = 32) were randomized to high (1500 mg/kg diet) or low (0 to 50 mg/kg diet) vitC for 10-12 weeks. At euthanasia, coronary artery segments were dissected and mounted in a wire-myograph...
July 3, 2017: Nutrients
J Kucinska-Lipka, I Gubanska, M Strankowski, H Cieśliński, N Filipowicz, H Janik
In this paper we described synthesis and characteristic of obtained hydrophilic polyurethanes (PURs) modified with ascorbic acid (commonly known as vitamin C). Such materials may find an application in the biomedical field, for example in the regenerative medicine of soft tissues, according to ascorbic acid wide influence on tissue regeneration Flora (2009), Szymańska-Pasternak et al. (2011), Taikarimi and Ibrahim (2011), Myrvik and Volk (1954), Li et al. (2001), Cursino et al. (2005) . Hydrophilic PURs were obtained with the use of amorphous α,ω-dihydroxy(ethylene-butylene adipate) (dHEBA) polyol, 1,4-butanediol (BDO) chain extender and aliphatic 4,4'-methylenebis(cyclohexyl isocyanate) (HMDI)...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
N Fewings, P N Gatt, F C McKay, G P Parnell, S D Schibeci, J Edwards, M A Basuki, A Goldinger, M J Fabis-Pedrini, A G Kermode, C P Manrique, J L McCauley, D Nickles, S E Baranzini, T Burke, S Vucic, G J Stewart, D R Booth
The data presented in this article are related to the research article entitled "The autoimmune risk gene ZMIZ1 is a vitamin D responsived marker of a molecular phenotype of multiple sclerosis" Fewings et al. (2017) [1]. Here we identify the set of genes correlated with ZMIZ1 in multiple cohorts, provide phenotypic details on those cohorts, and identify the genes negatively correlated with ZMIZ1 and the cells predominantly expressing those genes. We identify the metabolic pathways in which the molecular phenotype genes are over-represented...
April 2017: Data in Brief
Chantal Julia, Karen E Assmann, Nitin Shivappa, James R Hebert, Michael D Wirth, Serge Hercberg, Mathilde Touvier, Emmanuelle Kesse-Guyot
Chronic low-grade inflammation has been recognised as a key underlying mechanism for several chronic diseases, including cancer and CVD. Nutrition represents a host of key modifiable factors that influence chronic inflammation. Dietary inflammatory scores were developed to assess the inflammatory potential of the diet and have been associated with inflammatory biomarkers in cross-sectional and short-term longitudinal studies. The objective of this study was to investigate the relationship between the dietary inflammatory index (DII), the alternate dietary inflammatory index (ADII) and long-term C-reactive protein (CRP)...
January 2017: British Journal of Nutrition
Luana L Padilha, Ana Karina T D C França, Sueli I O da Conceição, Wyllyane Rayana C Carvalho, Mônica A Batalha, Antônio A M da Silva
The number of days of data required to accurately estimate usual nutrient intake of children is not well established. This study aims to calculate the variability and the number of days required to estimate usual nutrient intake in children aged 13-32 months. This cross-sectional study, which is part of the BRISA Project in São Luís, Maranhão, Brazil, involved 231 children from April 2011 to January 2013. Socio-economic and demographic data were collected using a questionnaire, and 3 non-consecutive days of food consumption were collected using a 24-h dietary recall (24HDR) survey...
January 2017: British Journal of Nutrition
Yatendra Parashar, Rashmi Kushwaha, Ashutosh Kumar, Kamal Agarwal, U S Singh, Mili Jain, S P Verma, A K Tripathi
INTRODUCTION: Patients of MPN commonly present with abnormalities in laboratory coagulation tests that are consistent with hypercoagulable state. Some individuals with MPN exhibit a pattern of exclusive bleeding or thrombotic events; many others have both bleeding and thrombosis during the course of the disease. AIM: This study was undertaken to assess the haemostatic defects and platelet functions in patients of MPN. MATERIALS AND METHODS: One year prospective study was conducted at a tertiary care centre in North India in Department of Pathology in collaboration with Department of Clinical Haematology...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
David S Ross, Khamir Mehta, Antonio Cabal
A better understanding of the molecular pathways regulating the bone remodeling process should help in the development of new antiresorptive regulators and anabolic regulators, that is, regulators of bone resorption and of bone formation. Understanding the mechanisms by which parathyroid hormone (PTH) influences bone formation and how it switches from anabolic to catabolic action is important for treating osteoporosis (Poole and Reeve in Curr Opin Pharmacol 5:612-617, 2005). In this paper we describe a mathematical model of bone remodeling that incorporates, extends, and integrates several models of particular aspects of this biochemical system (Cabal et al...
January 2017: Bulletin of Mathematical Biology
Jessica L Faulkner, Lorena M Amaral, Denise C Cornelius, Mark W Cunningham, Tarek Ibrahim, Autumn Heep, Nathan Campbell, Nathan Usry, Kedra Wallace, Florian Herse, Ralf Dechend, Babbette LaMarca
Autoantibodies to the ANG II type I receptor (AT1 -AA) are associated with preeclampsia (PE). We found that vitamin D supplementation reduced AT1 -AA and blood pressure (MAP) in the RUPP rat model of PE. However, it was undetermined whether the decrease in AT1 -AA was the mechanism whereby vitamin D lowered MAP or if it were through factors downstream of AT1 -AA. Uterine artery resistance index, placental ET-1, and soluble FMS-like tyrosine kinase-1 are increased with AT1 -AA-induced hypertension and are considered markers of PE in pregnant women...
January 1, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
R Ma, X L Deng, G L Du, C Li, S Xiao, Y Aibibai, J Zhu
To investigate the protective effect of the active form of vitamin D3, 1,25-(OH)2D3, on macrovasculopathy in rats with type 2 diabetes mellitus (T2DM), 8-week-old male Sprague-Dawley rats were randomly divided into control group, T2DM group, and treatment group. The T2DM model was established after 6 weeks by administering an intraperitoneal injection of streptozotocin (30 mg/kg). 1,25-(OH)2D3 was administered by gavage to rats in the treatment group, and an equal volume of peanut oil was administered to rats in the T2DM group...
June 3, 2016: Genetics and Molecular Research: GMR
Florian J Wegehaupt, Nancy Lunghi, Vanessa M G Hogger, Thomas Attin
The extrinsic sources for erosion-causing acids are primarily acidic beverages and foodstuffs. Effervescent tablets also contain organic acids (e.g. citric, tartaric, malic) in order to form carbon dioxide by contact with water – with the help of the carbonate salts of the tablets. To adequately inform patients about the possible erosive potential of effervescent tablets, this study was undertaken in order to investigate the erosive potential of effervescent tablets (ET), containing either a combination of vitamins and minerals or vitamins only, commercially available in Switzerland...
2016: Swiss Dental Journal
Xue-wen Gong, Jing-sheng Sun, Hao Liu, Hao Zhang, Xiao-lei Wu, Yu-hong Sun
An experiment was conducted in 2013 and 2014 at the Xinxiang Comprehensive Experimental Station, Chinese Academy of Agriculture Sciences. Water amount was estimated with the Ep-20 and pan coefficient. Responses of cucumber evapotranspiration (ET), yield, quality and water use efficiency (WUE) to different drip irrigation amounts (Kcp1: 0.25; Kcp2: 0.5; Kcp3: 0.75; Kcp4: 1.0; Kcp5: 1.25) were investigated. The possibility of developing drip irrigation scheduling using the 20 cm pan was also discussed. Results showed that the seasonal evapotranspiration of cucumber ranged between 129 and 314 mm, and the water consumption generally increased with the increase in drip irrigation water amount...
November 2015: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
C Guerra-Rivas, C Vieira, B Rubio, B Martínez, B Gallardo, A R Mantecón, P Lavín, T Manso
The effect of dietary treatment (CTRL, control; VIT-E, 500 mg kg(-1) vitamin E; GSE, 50 mg grape seed extract kg(-1); GP-5, 5% dried red grape pomace kg(-1)) on shelf life of lamb meat was studied. After slaughter (27 kg LBW), m. longissimus thoracis et lumborum was sliced, packaged under modified atmosphere (80:20%/O2:CO2) and stored in retail conditions for 14 days. At each sampling day (0, 4, 7, 11, 14), microbiological, physico-chemical and sensory characteristics were analysed. Meat from VIT-E presented lower microbial counts than CTRL, GSE and GP-5, without differences between polyphenol treatments (GSE and GP-5) and CTRL...
June 2016: Meat Science
B Mahmoudi, R Sahnoune, M Bouchenak
OBJECTIFS: La surveillance de l'état nutritionnel et la promotion d'une alimentation optimale sont des éléments essentiels des soins de santé de tous les enfants. L'objectif de notre travail est l'évaluation de l'état nutritionnel et l'estimation de la consommation alimentaire chez des enfants scolarisés à Oran. MéTHODES: Le poids et la taille sont mesurés auprès de 464 élèves, âgés entre 6 et 10 ans (F/G=252/212). Les seuils de l'Indice de Masse Corporelle (IMC) établis par l'IOTF et le PNNS ont été utilisés pour évaluer le statut pondéral des enfants...
December 2015: Annales de Cardiologie et D'angéiologie
C M Weaver, C M Gordon, K F Janz, H J Kalkwarf, J M Lappe, R Lewis, M O'Karma, T C Wallace, B S Zemel
Lifestyle choices influence 20-40 % of adult peak bone mass. Therefore, optimization of lifestyle factors known to influence peak bone mass and strength is an important strategy aimed at reducing risk of osteoporosis or low bone mass later in life. The National Osteoporosis Foundation has issued this scientific statement to provide evidence-based guidance and a national implementation strategy for the purpose of helping individuals achieve maximal peak bone mass early in life. In this scientific statement, we (1) report the results of an evidence-based review of the literature since 2000 on factors that influence achieving the full genetic potential for skeletal mass; (2) recommend lifestyle choices that promote maximal bone health throughout the lifespan; (3) outline a research agenda to address current gaps; and (4) identify implementation strategies...
April 2016: Osteoporosis International
M Struglia, C A Stamerra, P Di Giosia, P Giorgini, C Capanna, D Grassi, G Properzi, C Ferri
OBJECTIVE: Vitamin D deficiency is commonly associated with rheumatoid arthritis (RA), with an inverse correlation between Disease Activity Score (DAS28) and Health Assessment Questionnaire (HAQ). Vitamin D is known to have a systemic anti-inflammatory action. We aimed to evaluate the effects of vitamin D supplementation on biomarkers of inflammation and endothelial activation [high sensitivity C- reactive protein (hs-CRP) and endothelin-1 (ET-1)], flow mediated dilation (FMD) in patients with RA...
June 2015: Journal of Hypertension
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