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Vitamin C AND ET-1

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https://www.readbyqxmd.com/read/29074402/ergothioneine-stands-out-from-hercynine-in-the-reaction-with-singlet-oxygen-resistance-to-glutathione-and-tris-in-the-generation-of-specific-products-indicates-high-reactivity
#1
Christopher Stoffels, Mhmd Oumari, Aris Perrou, Andreas Termath, Waldemar Schlundt, Hans-Günther Schmalz, Mathias Schäfer, Vera Wewer, Sabine Metzger, Edgar Schömig, Dirk Gründemann
The candidate vitamin ergothioneine (ET), an imidazole-2-thione derivative of histidine betaine, is generally considered an antioxidant. However, the precise physiological role of ET is still unresolved. Here, we investigated in vitro the hypothesis that ET serves specifically to eradicate noxious singlet oxygen ((1)O2). Pure (1)O2 was generated by thermolysis at 37°C of N,N'-di(2,3-dihydroxypropyl)-1,4-naphthalenedipropanamide 1,4-endoperoxide (DHPNO2). Assays of DHPNO2 with ET or hercynine (= ET minus sulfur) at pH 7...
October 23, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28671625/vitamin-c-deficiency-reduces-muscarinic-receptor-coronary-artery-vasoconstriction-and-plasma-tetrahydrobiopterin-concentration-in-guinea-pigs
#2
Gry Freja Skovsted, Pernille Tveden-Nyborg, Maiken Marie Lindblad, Stine Normann Hansen, Jens Lykkesfeldt
Vitamin C (vitC) deficiency is associated with increased cardiovascular disease risk, but its specific interplay with arteriolar function is unclear. This study investigates the effect of vitC deficiency in guinea pigs on plasma biopterin status and the vasomotor responses in coronary arteries exposed to vasoconstrictor/-dilator agents. Dunkin Hartley female guinea pigs (n = 32) were randomized to high (1500 mg/kg diet) or low (0 to 50 mg/kg diet) vitC for 10-12 weeks. At euthanasia, coronary artery segments were dissected and mounted in a wire-myograph...
July 3, 2017: Nutrients
https://www.readbyqxmd.com/read/28415514/synthesis-and-characterization-of-cycloaliphatic-hydrophilic-polyurethanes-modified-with-l-ascorbic-acid-as-materials-for-soft-tissue-regeneration
#3
J Kucinska-Lipka, I Gubanska, M Strankowski, H Cieśliński, N Filipowicz, H Janik
In this paper we described synthesis and characteristic of obtained hydrophilic polyurethanes (PURs) modified with ascorbic acid (commonly known as vitamin C). Such materials may find an application in the biomedical field, for example in the regenerative medicine of soft tissues, according to ascorbic acid wide influence on tissue regeneration Flora (2009), Szymańska-Pasternak et al. (2011), Taikarimi and Ibrahim (2011), Myrvik and Volk (1954), Li et al. (2001), Cursino et al. (2005) . Hydrophilic PURs were obtained with the use of amorphous α,ω-dihydroxy(ethylene-butylene adipate) (dHEBA) polyol, 1,4-butanediol (BDO) chain extender and aliphatic 4,4'-methylenebis(cyclohexyl isocyanate) (HMDI)...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28275670/data-characterizing-the-zmiz1-molecular-phenotype-of-multiple-sclerosis
#4
N Fewings, P N Gatt, F C McKay, G P Parnell, S D Schibeci, J Edwards, M A Basuki, A Goldinger, M J Fabis-Pedrini, A G Kermode, C P Manrique, J L McCauley, D Nickles, S E Baranzini, T Burke, S Vucic, G J Stewart, D R Booth
The data presented in this article are related to the research article entitled "The autoimmune risk gene ZMIZ1 is a vitamin D responsived marker of a molecular phenotype of multiple sclerosis" Fewings et al. (2017) [1]. Here we identify the set of genes correlated with ZMIZ1 in multiple cohorts, provide phenotypic details on those cohorts, and identify the genes negatively correlated with ZMIZ1 and the cells predominantly expressing those genes. We identify the metabolic pathways in which the molecular phenotype genes are over-represented...
April 2017: Data in Brief
https://www.readbyqxmd.com/read/28166841/long-term-associations-between-inflammatory-dietary-scores-in-relation-to-long-term-c-reactive-protein-status-measured-12-years-later-findings-from-the-suppl%C3%A3-mentation-en-vitamines-et-min%C3%A3-raux-antioxydants-su-vi-max-cohort
#5
Chantal Julia, Karen E Assmann, Nitin Shivappa, James R Hebert, Michael D Wirth, Serge Hercberg, Mathilde Touvier, Emmanuelle Kesse-Guyot
Chronic low-grade inflammation has been recognised as a key underlying mechanism for several chronic diseases, including cancer and CVD. Nutrition represents a host of key modifiable factors that influence chronic inflammation. Dietary inflammatory scores were developed to assess the inflammatory potential of the diet and have been associated with inflammatory biomarkers in cross-sectional and short-term longitudinal studies. The objective of this study was to investigate the relationship between the dietary inflammatory index (DII), the alternate dietary inflammatory index (ADII) and long-term C-reactive protein (CRP)...
January 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28162108/nutrient-intake-variability-and-the-number-of-days-needed-to-estimate-usual-intake-in-children-aged-13-32-months
#6
Luana L Padilha, Ana Karina T D C França, Sueli I O da Conceição, Wyllyane Rayana C Carvalho, Mônica A Batalha, Antônio A M da Silva
The number of days of data required to accurately estimate usual nutrient intake of children is not well established. This study aims to calculate the variability and the number of days required to estimate usual nutrient intake in children aged 13-32 months. This cross-sectional study, which is part of the BRISA Project in São Luís, Maranhão, Brazil, involved 231 children from April 2011 to January 2013. Socio-economic and demographic data were collected using a questionnaire, and 3 non-consecutive days of food consumption were collected using a 24-h dietary recall (24HDR) survey...
January 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28050371/haemostatic-profile-in-patients-of-myeloproliferative-neoplasms-a-tertiary-care-centre-experience
#7
Yatendra Parashar, Rashmi Kushwaha, Ashutosh Kumar, Kamal Agarwal, U S Singh, Mili Jain, S P Verma, A K Tripathi
INTRODUCTION: Patients of MPN commonly present with abnormalities in laboratory coagulation tests that are consistent with hypercoagulable state. Some individuals with MPN exhibit a pattern of exclusive bleeding or thrombotic events; many others have both bleeding and thrombosis during the course of the disease. AIM: This study was undertaken to assess the haemostatic defects and platelet functions in patients of MPN. MATERIALS AND METHODS: One year prospective study was conducted at a tertiary care centre in North India in Department of Pathology in collaboration with Department of Clinical Haematology...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27905067/mathematical-model-of-bone-remodeling-captures-the-antiresorptive-and-anabolic-actions-of-various-therapies
#8
David S Ross, Khamir Mehta, Antonio Cabal
A better understanding of the molecular pathways regulating the bone remodeling process should help in the development of new antiresorptive regulators and anabolic regulators, that is, regulators of bone resorption and of bone formation. Understanding the mechanisms by which parathyroid hormone (PTH) influences bone formation and how it switches from anabolic to catabolic action is important for treating osteoporosis (Poole and Reeve in Curr Opin Pharmacol 5:612-617, 2005). In this paper we describe a mathematical model of bone remodeling that incorporates, extends, and integrates several models of particular aspects of this biochemical system (Cabal et al...
January 2017: Bulletin of Mathematical Biology
https://www.readbyqxmd.com/read/27903510/vitamin-d-supplementation-reduces-some-at1-aa-induced-downstream-targets-implicated-in-preeclampsia-including-hypertension
#9
Jessica L Faulkner, Lorena M Amaral, Denise C Cornelius, Mark W Cunningham, Tarek Ibrahim, Autumn Heep, Nathan Campbell, Nathan Usry, Kedra Wallace, Florian Herse, Ralf Dechend, Babbette LaMarca
Autoantibodies to the ANG II type I receptor (AT1-AA) are associated with preeclampsia (PE). We found that vitamin D supplementation reduced AT1-AA and blood pressure (MAP) in the RUPP rat model of PE. However, it was undetermined whether the decrease in AT1-AA was the mechanism whereby vitamin D lowered MAP or if it were through factors downstream of AT1-AA. Uterine artery resistance index, placental ET-1, and soluble FMS-like tyrosine kinase-1 are increased with AT1-AA-induced hypertension and are considered markers of PE in pregnant women...
January 1, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/27323139/active-vitamin-d3-1-25-oh-2d3-protects-against-macrovasculopathy-in-a-rat-model-of-type-2-diabetes-mellitus
#10
R Ma, X L Deng, G L Du, C Li, S Xiao, Y Aibibai, J Zhu
To investigate the protective effect of the active form of vitamin D3, 1,25-(OH)2D3, on macrovasculopathy in rats with type 2 diabetes mellitus (T2DM), 8-week-old male Sprague-Dawley rats were randomly divided into control group, T2DM group, and treatment group. The T2DM model was established after 6 weeks by administering an intraperitoneal injection of streptozotocin (30 mg/kg). 1,25-(OH)2D3 was administered by gavage to rats in the treatment group, and an equal volume of peanut oil was administered to rats in the T2DM group...
June 3, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27278776/erosive-potential-of-vitamin-and-vitamin-mineral-effervescent-tablets
#11
COMPARATIVE STUDY
Florian J Wegehaupt, Nancy Lunghi, Vanessa M G Hogger, Thomas Attin
The extrinsic sources for erosion-causing acids are primarily acidic beverages and foodstuffs. Effervescent tablets also contain organic acids (e.g. citric, tartaric, malic) in order to form carbon dioxide by contact with water – with the help of the carbonate salts of the tablets. To adequately inform patients about the possible erosive potential of effervescent tablets, this study was undertaken in order to investigate the erosive potential of effervescent tablets (ET), containing either a combination of vitamins and minerals or vitamins only, commercially available in Switzerland...
2016: Swiss Dental Journal
https://www.readbyqxmd.com/read/26915194/-irrigation-scheduling-with-a-20-cm-standard-pan-for-drip-irrigated-cucumber-grown-in-solar-greenhouse-in-the-north-china-plain
#12
Xue-wen Gong, Jing-sheng Sun, Hao Liu, Hao Zhang, Xiao-lei Wu, Yu-hong Sun
An experiment was conducted in 2013 and 2014 at the Xinxiang Comprehensive Experimental Station, Chinese Academy of Agriculture Sciences. Water amount was estimated with the Ep-20 and pan coefficient. Responses of cucumber evapotranspiration (ET), yield, quality and water use efficiency (WUE) to different drip irrigation amounts (Kcp1: 0.25; Kcp2: 0.5; Kcp3: 0.75; Kcp4: 1.0; Kcp5: 1.25) were investigated. The possibility of developing drip irrigation scheduling using the 20 cm pan was also discussed. Results showed that the seasonal evapotranspiration of cucumber ranged between 129 and 314 mm, and the water consumption generally increased with the increase in drip irrigation water amount...
November 2015: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
https://www.readbyqxmd.com/read/26908145/effects-of-grape-pomace-in-growing-lamb-diets-compared-with-vitamin-e-and-grape-seed-extract-on-meat-shelf-life
#13
RANDOMIZED CONTROLLED TRIAL
C Guerra-Rivas, C Vieira, B Rubio, B Martínez, B Gallardo, A R Mantecón, P Lavín, T Manso
The effect of dietary treatment (CTRL, control; VIT-E, 500 mg kg(-1) vitamin E; GSE, 50 mg grape seed extract kg(-1); GP-5, 5% dried red grape pomace kg(-1)) on shelf life of lamb meat was studied. After slaughter (27 kg LBW), m. longissimus thoracis et lumborum was sliced, packaged under modified atmosphere (80:20%/O2:CO2) and stored in retail conditions for 14 days. At each sampling day (0, 4, 7, 11, 14), microbiological, physico-chemical and sensory characteristics were analysed. Meat from VIT-E presented lower microbial counts than CTRL, GSE and GP-5, without differences between polyphenol treatments (GSE and GP-5) and CTRL...
June 2016: Meat Science
https://www.readbyqxmd.com/read/26877382/p-080-nutritional-status-and-diet-in-west-algerian-scholar-children
#14
B Mahmoudi, R Sahnoune, M Bouchenak
OBJECTIFS: La surveillance de l'état nutritionnel et la promotion d'une alimentation optimale sont des éléments essentiels des soins de santé de tous les enfants. L'objectif de notre travail est l'évaluation de l'état nutritionnel et l'estimation de la consommation alimentaire chez des enfants scolarisés à Oran. MéTHODES: Le poids et la taille sont mesurés auprès de 464 élèves, âgés entre 6 et 10 ans (F/G=252/212). Les seuils de l'Indice de Masse Corporelle (IMC) établis par l'IOTF et le PNNS ont été utilisés pour évaluer le statut pondéral des enfants...
December 2015: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/26856587/the-national-osteoporosis-foundation-s-position-statement-on-peak-bone-mass-development-and-lifestyle-factors-a-systematic-review-and-implementation-recommendations
#15
REVIEW
C M Weaver, C M Gordon, K F Janz, H J Kalkwarf, J M Lappe, R Lewis, M O'Karma, T C Wallace, B S Zemel
Lifestyle choices influence 20-40 % of adult peak bone mass. Therefore, optimization of lifestyle factors known to influence peak bone mass and strength is an important strategy aimed at reducing risk of osteoporosis or low bone mass later in life. The National Osteoporosis Foundation has issued this scientific statement to provide evidence-based guidance and a national implementation strategy for the purpose of helping individuals achieve maximal peak bone mass early in life. In this scientific statement, we (1) report the results of an evidence-based review of the literature since 2000 on factors that influence achieving the full genetic potential for skeletal mass; (2) recommend lifestyle choices that promote maximal bone health throughout the lifespan; (3) outline a research agenda to address current gaps; and (4) identify implementation strategies...
April 2016: Osteoporosis International
https://www.readbyqxmd.com/read/26102946/6d-06-vitamin-d-deficiency-and-endothelial-dysfunction-in-rheumatoid-arthritis-patients
#16
M Struglia, C A Stamerra, P Di Giosia, P Giorgini, C Capanna, D Grassi, G Properzi, C Ferri
OBJECTIVE: Vitamin D deficiency is commonly associated with rheumatoid arthritis (RA), with an inverse correlation between Disease Activity Score (DAS28) and Health Assessment Questionnaire (HAQ). Vitamin D is known to have a systemic anti-inflammatory action. We aimed to evaluate the effects of vitamin D supplementation on biomarkers of inflammation and endothelial activation [high sensitivity C- reactive protein (hs-CRP) and endothelin-1 (ET-1)], flow mediated dilation (FMD) in patients with RA...
June 2015: Journal of Hypertension
https://www.readbyqxmd.com/read/25803078/the-contribution-of-methionine-to-the-stability-of-the-escherichia-coli-metniq-abc-transporter-substrate-binding-protein-complex
#17
Phong T Nguyen, Qi Wen Li, Neena S Kadaba, Jeffrey Y Lai, Janet G Yang, Douglas C Rees
Despite the ubiquitous role of ATP-binding cassette (ABC) importers in nutrient uptake, only the Escherichia coli maltose and vitamin B12 ABC transporters have been structurally characterized in multiple conformations relevant to the alternating access transport mechanism. To complement our previous structure determination of the E. coli MetNI methionine importer in the inward facing conformation (Kadaba et al. (2008) Science 321, 250-253), we have explored conditions stabilizing the outward facing conformation...
September 2015: Biological Chemistry
https://www.readbyqxmd.com/read/25656533/comparison-of-methods-to-account-for-implausible-reporting-of-energy-intake-in-epidemiologic-studies
#18
COMPARATIVE STUDY
Jinnie J Rhee, Laura Sampson, Eunyoung Cho, Michael D Hughes, Frank B Hu, Walter C Willett
In a recent article in the American Journal of Epidemiology by Mendez et al. (Am J Epidemiol. 2011;173(4):448-458), the use of alternative approaches to the exclusion of implausible energy intakes led to significantly different cross-sectional associations between diet and body mass index (BMI), whereas the use of a simpler recommended criteria (<500 and >3,500 kcal/day) yielded no meaningful change. However, these findings might have been due to exclusions made based on weight, a primary determinant of BMI...
February 15, 2015: American Journal of Epidemiology
https://www.readbyqxmd.com/read/25651444/overall-and-abdominal-adiposity-in-midlife-and-subsequent-cognitive-function
#19
E Kesse-Guyot, V A Andreeva, M Touvier, C Jeandel, M Ferry, S Hercberg, P Galan
OBJECTIVES: The scientific literature supports a link between midlife adiposity and cognitive function or decline but most studies to-date have investigated only overall adiposity, often omitting important confounders from the analyses. We investigated in a cross-time design the relationships between two different midlife adiposity markers and subsequent cognitive function, testing midlife dietary patterns as a potential confounder of the associations. DESIGN: The study was based on the «Supplémentation en Vitamines et Minéraux Antioxydants» randomized trial (SU...
February 2015: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/25532375/-clinical-characteristics-and-combined-use-of-medicine-analysis-of-2-991-hospitalized-patients-with-psoriasis-based-on-real-world-database
#20
Jian-hong Li, Zhi-fei Wang, Yan-ming Xie, Wei Zhao
To analyze the clinical characteristics and combined use of chemical and traditional Chinese medicine (TCM) medicine of hospitalized patients with psoriasis base on real world database, 2 991 cases of hospitalized patients with psoriasis in hospital information system (HIS) database from 16 hospitals in China were analyzed for general hospitalization information, combined diseases and combined use of drugs et al. The results showed that half of inpatients aged 18-45 years old. The most common syndrome of TCM was intrinsic blood heat...
September 2014: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
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