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Klein Christoph

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https://www.readbyqxmd.com/read/28728164/disseminated-tumour-cells-with-highly-aberrant-genomes-are-linked-to-poor-prognosis-in-operable-oesophageal-adenocarcinoma
#1
Sarah Schumacher, Christoph Bartenhagen, Martin Hoffmann, Daniel Will, Johannes C Fischer, Stephan E Baldus, Christian Vay, Georg Fluegen, Levent Dizdar, Daniel Vallböhmer, Christoph A Klein, Wolfram T Knoefel, Nikolas H Stoecklein, Birte Möhlendick
BACKGROUND: Chromosomal instability (CIN) has repeatedly been identified as a prognostic marker. Here we evaluated the percentage of aberrant genome per cell (PAG) as a measure of CIN in single disseminated tumour cells (DTC) isolated from patients with operable oesophageal adenocarcinoma (EAC), to assess the impact of CIN(high) DTCs on prognosis. METHODS: We isolated CK18(positive) DTCs from bone marrow (BM) or lymph node (LN) preparations of operable EAC patients...
July 20, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28707840/erratum
#2
(no author information available yet)
L'article « L'urogériatrie du médecin généraliste » [ Frequent uro-geriatric symptoms : helpful tools for general practitioners], Rev Med Suisse 2016;12:2077-82 [PMID: 28700153] paru dans le numéro 541 du 30 novembre 2016 de la Revue médicale suisse, a également été coécrit par le Dr Caroline Carera Sager, Service d'urologie, HUG, Genève. Les auteurs sont donc : Drs Guillaume Altwegg, Jacques Klein, Grégory Wirth, Caroline Carera Sager et Pr Christophe E. Iselin.
December 14, 2016: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28701277/the-epigenetic-architecture-at-gene-promoters-determines-cell-type-specific-lps-tolerance
#3
Kerstin Klein, Mojca Frank-Bertoncelj, Emmanuel Karouzakis, Renate E Gay, Christoph Kolling, Adrian Ciurea, Nagihan Bostanci, Georgios N Belibasakis, Lih-Ling Lin, Oliver Distler, Steffen Gay, Caroline Ospelt
Synovial fibroblasts (SF) drive inflammation and joint destruction in chronic arthritis. Here we show that SF possess a distinct type of LPS tolerance compared to macrophages and other types of fibroblasts. In SF and dermal fibroblasts, genes that were non-tolerizable after repeated LPS stimulation included pro-inflammatory cytokines, chemokines and matrix metalloproteinases, whereas anti-viral genes were tolerizable. In macrophages, all measured genes were tolerizable, whereas in gingival and foreskin fibroblasts these genes were non-tolerizable...
July 9, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28701026/-ultrasound-in-oncology-current-perspectives
#4
Corinna Trenker, Christian Görg, Christian Jenssen, Stefan Klein, Andreas Neubauer, Uwe Wagner, Christoph F Dietrich
In tumor diagnostics, especially in the staging diagnostic of tumor patients, ultrasound is predominantly an additive method in the age of modern imaging (CT/MRT/PET-CT), because of the limitation by interobserver variability and poor sound conditions. The aim of this thesis is to elaborate specific oncological questions on the sonography and to describe the requirements for sonography and the importance of the method in the diagnosis of tumor diseases in the age of CT, MRT and PET-CT. In general, the requirements on the sonography must be differentiated between primary diagnosis, staging diagnostic, treatment response, and tumor aftercare...
July 12, 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/28700153/-frequent-uro-geriatric-symptoms-helpful-tools-for-general-practitioners
#5
Guillaume Altwegg, Jacques Klein, Grégory Wirth, Christophe E Iselin
Each developed country faces an aging population. Increase of age rises the risk to develop urologic pathology especially in men. Routine investigation and diagnostic of urologic pathology important, however must take into account the patient in his globality (including age, comorbidities, drug medication as well as sociocultural environment). The aim of this article is to help the general practitioner in taking decisions with frequent uro-geriatric symptoms. Bladder catheterization remains an invasive treatment and indication should be regularly re-evaluated...
November 30, 2016: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28699939/implementing-acove-quality-indicators-as-an-intervention-checklist-to-improve-care-for-hospitalized-older-adults
#6
Liron Sinvani, Andrzej Kozikowski, Christopher Smilios, Vidhi Patel, Guang Qiu, Meredith Akerman, Martin Lesser, David Rosenberg, Gisele Wolf-Klein, Renee Pekmezaris
BACKGROUND: Medicare patients account for approximately 50% of hospital days. Hospitalization in older adults often results in poor outcomes. OBJECTIVE: To test the feasibility and impact of using Assessing Care of Vulnerable Elders (ACOVE) quality indicators (QIs) as a therapeutic intervention to improve care of hospitalized older adults. DESIGN: >Post-test only prospective intervention with a nonequivalent retrospective control group...
July 2017: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/28684861/tracing-the-influence-of-land-use-change-on-water-quality-and-coral-reefs-using-a-bayesian-model
#7
Christopher J Brown, Stacy D Jupiter, Simon Albert, Carissa J Klein, Sangeeta Mangubhai, Joseph M Maina, Peter Mumby, Jon Olley, Ben Stewart-Koster, Vivitskaia Tulloch, Amelia Wenger
Coastal ecosystems can be degraded by poor water quality. Tracing the causes of poor water quality back to land-use change is necessary to target catchment management for coastal zone management. However, existing models for tracing the sources of pollution require extensive data-sets which are not available for many of the world's coral reef regions that may have severe water quality issues. Here we develop a hierarchical Bayesian model that uses freely available satellite data to infer the connection between land-uses in catchments and water clarity in coastal oceans...
July 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28666792/post-kidney-transplant-robot-assisted-laparoscopic-ureteral-donor-receiver-anastomosis-for-kidney-graft-reflux-or-stricture-disease
#8
Daniel A Benamran, Jacques Klein, Karine Hadaya, Gregory Wirth, Pierre-Yves Martin, Christophe E Iselin
OBJECTIVES: To report our experience with robot-assisted ureteral anastomosis for kidney graft. Kidney graft complex ureteral strictures and/or symptomatic vesico-ureteral reflux may require complex reconstruction. This is classically done through an open surgical access, which adds to the morbidity of kidney transplantation. The da Vinci robot enables to perform complex laparoscopic procedures, and may hence be used for such reconstructions. METHODS: we retrospectively reviewed all patients undergoing robotic surgical revision for stricture or reflux disease over a three years period...
June 27, 2017: Urology
https://www.readbyqxmd.com/read/28659934/morphological-plant-modeling-unleashing-geometric-and-topological-potential-within-the-plant-sciences
#9
REVIEW
Alexander Bucksch, Acheampong Atta-Boateng, Akomian F Azihou, Dorjsuren Battogtokh, Aly Baumgartner, Brad M Binder, Siobhan A Braybrook, Cynthia Chang, Viktoirya Coneva, Thomas J DeWitt, Alexander G Fletcher, Malia A Gehan, Diego Hernan Diaz-Martinez, Lilan Hong, Anjali S Iyer-Pascuzzi, Laura L Klein, Samuel Leiboff, Mao Li, Jonathan P Lynch, Alexis Maizel, Julin N Maloof, R J Cody Markelz, Ciera C Martinez, Laura A Miller, Washington Mio, Wojtek Palubicki, Hendrik Poorter, Christophe Pradal, Charles A Price, Eetu Puttonen, John B Reese, Rubén Rellán-Álvarez, Edgar P Spalding, Erin E Sparks, Christopher N Topp, Joseph H Williams, Daniel H Chitwood
The geometries and topologies of leaves, flowers, roots, shoots, and their arrangements have fascinated plant biologists and mathematicians alike. As such, plant morphology is inherently mathematical in that it describes plant form and architecture with geometrical and topological techniques. Gaining an understanding of how to modify plant morphology, through molecular biology and breeding, aided by a mathematical perspective, is critical to improving agriculture, and the monitoring of ecosystems is vital to modeling a future with fewer natural resources...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28653120/automation-of-radiation-treatment-planning-evaluation-of-head-and-neck-cancer-patient-plans-created-by-the-pinnacle-3-scripting-and-auto-planning-functions
#10
Stefan Speer, Andreas Klein, Lukas Kober, Alexander Weiss, Indra Yohannes, Christoph Bert
BACKGROUND: Intensity-modulated radiotherapy (IMRT) techniques are now standard practice. IMRT or volumetric-modulated arc therapy (VMAT) allow treatment of the tumor while simultaneously sparing organs at risk. Nevertheless, treatment plan quality still depends on the physicist's individual skills, experiences, and personal preferences. It would therefore be advantageous to automate the planning process. This possibility is offered by the Pinnacle(3) treatment planning system (Philips Healthcare, Hamburg, Germany) via its scripting language or Auto-Planning (AP) module...
August 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28650479/aml1-eto-requires-enhanced-c-d-box-snorna-rnp-formation-to-induce-self-renewal-and-leukaemia
#11
Fengbiao Zhou, Yi Liu, Christian Rohde, Cornelius Pauli, Dennis Gerloff, Marcel Köhn, Danny Misiak, Nicole Bäumer, Chunhong Cui, Stefanie Göllner, Thomas Oellerich, Hubert Serve, Maria-Paz Garcia-Cuellar, Robert Slany, Jaroslaw P Maciejewski, Bartlomiej Przychodzen, Barbara Seliger, Hans-Ulrich Klein, Christoph Bartenhagen, Wolfgang E Berdel, Martin Dugas, Makoto Mark Taketo, Daneyal Farouq, Schraga Schwartz, Aviv Regev, Josée Hébert, Guy Sauvageau, Caroline Pabst, Stefan Hüttelmaier, Carsten Müller-Tidow
Leukaemogenesis requires enhanced self-renewal, which is induced by oncogenes. The underlying molecular mechanisms remain incompletely understood. Here, we identified C/D box snoRNAs and rRNA 2'-O-methylation as critical determinants of leukaemic stem cell activity. Leukaemogenesis by AML1-ETO required expression of the groucho-related amino-terminal enhancer of split (AES). AES functioned by inducing snoRNA/RNP formation via interaction with the RNA helicase DDX21. Similarly, global loss of C/D box snoRNAs with concomitant loss of rRNA 2'-O-methylation resulted in decreased leukaemia self-renewal potential...
June 26, 2017: Nature Cell Biology
https://www.readbyqxmd.com/read/28648906/comt-genotype-is-differentially-associated-with-single-trial-variability-of-erps-as-a-function-of-memory-type
#12
Hadiseh Nowparast Rostami, Christopher W N Saville, Christoph Klein, Guang Ouyang, Werner Sommer, Changsong Zhou, Andrea Hildebrandt
Previous research on the association between intra-subject variability (ISV) in reaction times (RTs) and the Val(158)Met polymorphism of the catechol-o-methyltransferase gene (COMT; rs4680) has yielded mixed results. The present study compared the associations between COMT genotype and ISV in P3b latency measured during working and secondary memory tasks using residue iteration decomposition (RIDE) of single trial latencies. We compared the outcome of the present analyses with a previous analysis of the same data (N=70, n-back tasks) using an alternative single-trial method...
June 23, 2017: Biological Psychology
https://www.readbyqxmd.com/read/28646574/a-novel-habitat-based-approach-to-predict-impacts-of-marine-protected-areas-on-fishers
#13
João B Teixeira, Rodrigo L Moura, Morena Mills, Carissa Klein, Christopher J Brown, Vanessa M Adams, Hedley Grantham, Matthew Watts, Deborah Faria, Gilberto M Amado-Filho, Alex C Bastos, Reinaldo Lourival, Hugh P Possingham
While marine protected areas (MPAs) can simultaneously contribute to biodiversity conservation and fisheries management, the global network is biased towards particular ecosystem types, as it was largely established in an ad hoc fashion. The optimization of trade-offs between biodiversity benefits and socio-economic values increases implementation success and minimizes enforcement costs in the long run, but is often neglected in marine spatial planning (MSP). Although the acquisition of spatially explicit socioeconomic data is often perceived as a costly/secondary step in MSP, it is critical to account for lost opportunities by people whose activities will be restricted, especially fishers...
June 24, 2017: Conservation Biology: the Journal of the Society for Conservation Biology
https://www.readbyqxmd.com/read/28646568/blink-r1-latency-utility-in-diagnosis-and-treatment-assessment-of-poems-and-cidp
#14
Wei Wang, William J Litchy, Michelle L Mauermann, P James B Dyck, Angela Dispenzieri, Jay Mandrekar, Peter J Dyck, Christopher J Klein
INTRODUCTION: In POEMS and CIDP, limb nerve conduction studies (NCS) are limited in identifying demyelination and detecting treatment effects in severely affected patients. Blink R1-latency may improve these assessments. METHODS: POEMS and CIDP patients having undergone NCS and blink reflex were identified. Correlations between R1-latency, limb NCS and neuropathy impairment scores (NIS) were compared. RESULTS: With182 patients (124 POEMS, 58 CIDP) identified, R1-prolongation (>13ms) occurred in 64...
June 23, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28637796/quantifying-the-genetic-correlation-between-multiple-cancer-types
#15
Sara Lindström, Hilary Finucane, Brendan Bulik-Sullivan, Fredrick R Schumacher, Christopher I Amos, Rayjean J Hung, Kristin Rand, Stephen B Gruber, David Conti, Jennifer B Permuth, Hui-Yi Lin, Ellen L Goode, Thomas A Sellers, Laufey T Amundadottir, Rachael Stolzenberg-Solomon, Alison Klein, Gloria Petersen, Harvey Risch, Brian Wolpin, Li Hsu, Jeroen R Huyghe, Jenny Chang Claude, Andrew Chan, Sonja Berndt, Rosalind A Eeles, Douglas Easton, Christopher A Haiman, David J Hunter, Benjamin Neale, Alkes Price, Peter Kraft
Many cancers share specific genetic risk factors including both rare high-penetrance mutations and common single nucleotide polymorphisms (SNPs) identified through genome-wide association studies (GWAS). However, little is known about the overall shared heritability across cancers. Quantifying the extent to which two distinct cancers share genetic origin will give insights to shared biological mechanisms underlying cancer and inform design for future genetic association studies. In this study, we estimated the pair-wise genetic correlation between six cancer types (breast, colorectal, lung, ovarian, pancreatic and prostate) using cancer-specific GWAS summary statistics data based on 66,958 case and 70,665 control subjects of European ancestry...
June 21, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28636958/protective-and-pathological-immunity-during-central-nervous-system-infections
#16
REVIEW
Robyn S Klein, Christopher A Hunter
The concept of immune privilege of the central nervous system (CNS) has dominated the study of inflammatory processes in the brain. However, clinically relevant models have highlighted that innate pathways limit pathogen invasion of the CNS and adaptive immunity mediates control of many neural infections. As protective responses can result in bystander damage, there are regulatory mechanisms that balance protective and pathological inflammation, but these mechanisms might also allow microbial persistence. The focus of this review is to consider the host-pathogen interactions that influence neurotropic infections and to highlight advances in our understanding of innate and adaptive mechanisms of resistance as key determinants of the outcome of CNS infection...
June 20, 2017: Immunity
https://www.readbyqxmd.com/read/28636654/characterization-of-human-fcrl4-positive-b-cells
#17
Michel Jourdan, Nicolas Robert, Maïlys Cren, Coraline Thibaut, Christophe Duperray, Alboukadel Kassambara, Michel Cogné, Karin Tarte, Bernard Klein, Jérôme Moreaux
FCRL4 is an immunoregulatory receptor that belongs to the Fc receptor-like (FCRL) family. In healthy individuals, FCRL4 is specifically expressed by memory B cells (MBCs) localized in sub-epithelial regions of lymphoid tissues. Expansion of FCRL4+ B cells has been observed in blood and other tissues in various infectious and autoimmune disorders. Currently, the mechanisms involved in pathological FCRL4+ B cell generation are actively studied, but they remain elusive. As in vivo FCRL4+ cells are difficult to access and to isolate, here we developed a culture system to generate in vitro FCRL4+ B cells from purified MBCs upon stimulation with soluble CD40 ligand and/or CpG DNA to mimic T-cell dependent and/or T-cell independent activation, respectively...
2017: PloS One
https://www.readbyqxmd.com/read/28628235/expanded-phenotypes-and-outcomes-among-256-lgi1-caspr2-igg-positive-patients
#18
Avi Gadoth, Sean J Pittock, Divyanshu Dubey, Andrew McKeon, Jeff W Britton, John E Schmeling, Aurelia Smith, Amy L Kotsenas, Robert E Watson, Daniel H Lachance, Eoin P Flanagan, Vanda A Lennon, Christopher J Klein
OBJECTIVE: To describe an expanded phenotypic spectrum and longitudinal outcome in 256 LGI1-IgG or CASPR2-IgG seropositive patients. METHODS: Patients were identified through service neural autoantibody evaluation. Ninety-five had longitudinal follow-up (7-456 months; median 35). RESULTS: Among 3,910 patients tested, 196 were LGI1-IgG-positive; 51 were CASPR2-IgG-positive and 9 were dual-positive. CSF-testing was less sensitive than serum-testing, detecting only 24/38 LGI1-IgG-positive (63%) and 5/6 CASPR2-IgG-positive (83%)...
June 19, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28625372/multicenter-automatic-defibrillator-implantation-trial-subcutaneous-implantable-cardioverter-defibrillator-madit-s-icd-design-and-clinical-protocol
#19
Valentina Kutyifa, Christopher Beck, Mary W Brown, David Cannom, James Daubert, Mark Estes, Henry Greenberg, Ilan Goldenberg, Stephen Hammes, David Huang, Helmut Klein, Reinoud Knops, Mikhail Kosiborod, Jeanne Poole, Claudio Schuger, Jagmeet P Singh, Scott Solomon, David Wilber, Wojciech Zareba, Arthur J Moss
Patients with diabetes mellitus, prior myocardial infarction, older age, and a relatively preserved left ventricular ejection fraction remain at risk for sudden cardiac death that is potentially amenable by the subcutaneous implantable cardioverter defibrillator with a good risk-benefit profile. The launched MADIT S-ICD study is designed to test the hypothesis that post-myocardial infarction diabetes patients with relatively preserved ejection fraction of 36%-50% will have a survival benefit from a subcutaneous implantable cardioverter defibrillator...
July 2017: American Heart Journal
https://www.readbyqxmd.com/read/28619530/neural-networks-underlying-language-and-social-cognition-during-self-other-processing-in-autism-spectrum-disorders
#20
Rajesh K Kana, Emma B Sartin, Carl Stevens, Hrishikesh D Deshpande, Christopher Klein, Mark R Klinger, Laura Grofer Klinger
The social communication impairments defining autism spectrum disorders (ASD) may be built upon core deficits in perspective-taking, language processing, and self-other representation. Self-referential processing entails the ability to incorporate self-awareness, self-judgment, and self-memory in information processing. Very few studies have examined the neural bases of integrating self-other representation and semantic processing in individuals with ASD. The main objective of this functional MRI study is to examine the role of language and social brain networks in self-other processing in young adults with ASD...
June 12, 2017: Neuropsychologia
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