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REVIEW
Christoph Bachofen, Shersingh Joseph Tumber-Dávila, D Scott Mackay, Nate G McDowell, Andrea Carminati, Tamir Klein, Benjamin D Stocker, Maurizio Mencuccini, Charlotte Grossiord
Plant water uptake from the soil is a crucial element of the global hydrological cycle and essential for vegetation drought resilience. Yet, knowledge of how the distribution of water uptake depth (WUD) varies across species, climates, and seasons is scarce relative to our knowledge of aboveground plant functions. With a global literature review, we found that average WUD varied more among biomes than plant functional types (i.e. deciduous/evergreen broadleaves and conifers), illustrating the importance of the hydroclimate, especially precipitation seasonality, on WUD...
April 22, 2024: New Phytologist
#2
JOURNAL ARTICLE
Sascha Meyer, Johannes Bay, Axel R Franz, Harald Erhardt, Lars Klein, Jutta Petzinger, Christoph Binder, Susanne Kirschenhofer, Anja Stein, Britta Hüning, Axel Heep, Eva Cloppenburg, Julia Muyimbwa, Torsten Ott, Julia Sandkötter, Norbert Teig, Susanne Wiegand, Michael Schroth, Andrea Kick, Donald Wurm, Corinna Gebauer, Knud Linnemann, Jochen Kittel, Christian Wieg, Ursula Kiechl-Kohlendorfer, Susanne Schmidt, Ralf Böttger, Wolfgang Thomas, Francisco Brevis Nunez, Antje Stockmann, Thomas Kriebel, Andreas Müller, Daniel Klotz, Patrick Morhart, Donatus Nohr, Hans Konrad Biesalski, Eleni Z Giannopoulou, Susanne Hilt, Martin Poryo, Stefan Wagenpfeil, Nadja Haiden, Christian Ruckes, Anne Ehrlich, Ludwig Gortner
BACKGROUND: Vitamin A plays a key role in lung development, but there is no consensus regarding the optimal vitamin A dose and administration route in extremely low birthweight (ELBW) infants. We aimed to assess whether early postnatal additional high-dose fat-soluble enteral vitamin A supplementation versus placebo would lower the rate of moderate or severe bronchopulmonary dysplasia or death in ELBW infants receiving recommended basic enteral vitamin A supplementation. METHODS: This prospective, multicentre, randomised, parallel-group, double-blind, placebo-controlled, investigator-initiated phase 3 trial conducted at 29 neonatal intensive care units in Austria and Germany assessed early high-dose enteral vitamin A supplementation (5000 international units [IU]/kg per day) or placebo (peanut oil) for 28 days in ELBW infants...
April 18, 2024: Lancet Respiratory Medicine
#3
JOURNAL ARTICLE
Thomas Klein, Julia Grüner, Maximilian Breyer, Jan Schlegel, Nicole Michelle Schottmann, Lukas Hofmann, Kevin Gauss, Rebecca Mease, Christoph Erbacher, Laura Finke, Alexandra Klein, Katharina Klug, Franziska Karl-Schöller, Bettina Vignolo, Sebastian Reinhard, Tamara Schneider, Katharina Günther, Julian Fink, Jan Dudek, Christoph Maack, Eva Klopocki, Jürgen Seibel, Frank Edenhofer, Erhard Wischmeyer, Markus Sauer, Nurcan Üçeyler
Acral burning pain triggered by fever, thermal hyposensitivity and skin denervation are hallmarks of small fibre neuropathy in Fabry disease, a life-threatening X-linked lysosomal storage disorder. Variants in the gene encoding alpha-galactosidase A may lead to impaired enzyme activity with cellular accumulation of globotriaosylceramide. To study the underlying pathomechanism of Fabry-associated small fibre neuropathy, we generated a neuronal in vitro disease model using patient-derived induced pluripotent stem cells from three Fabry patients and one healthy control...
2024: Brain communications
#4
JOURNAL ARTICLE
Hampus Olsson, Jason Michael Millward, Ludger Starke, Thomas Gladytz, Tobias Klein, Jana Fehr, Wei-Chang Lai, Christoph Lippert, Thoralf Niendorf, Sonia Waiczies
Magnetic Resonance Imaging (MRI) datasets from epidemiological studies often show a lower prevalence of motion artifacts than what is encountered in clinical practice. These artifacts can be unevenly distributed between subject groups and studies which introduces a bias that needs addressing when augmenting data for machine learning purposes. Since unreconstructed multi-channel k-space data is typically not available for population-based MRI datasets, motion simulations must be performed using signal magnitude data...
2024: PloS One
#5
JOURNAL ARTICLE
Ethan K Murphy, Spencer R Bertsch, Samuel B Klein, Navid Rashedi, Yifei Sun, Michael J Joyner, Timothy B Curry, Christopher P Johnson, Riley J Regimbal, Chad C Wiggins, Jonathon W Senefeld, John R A Shepherd, Jonathan Thomas Elliott, Ryan J Halter, Vikrant S Vaze, Norman A Paradis
Occult hemorrhages after trauma can be present insidiously, and if not detected early enough can result in patient death. This study evaluated a hemorrhage model on 18 human subjects, comparing the performance of traditional vital signs to multiple off-the-shelf non-invasive biomarkers. A validated lower body negative pressure (LBNP) model was used to induce progression towards hypovolemic cardiovascular instability. Traditional vital signs included mean arterial pressure (MAP), electrocardiography (ECG), plethysmography (Pleth), and the test systems utilized electrical impedance via commercial electrical impedance tomography (EIT) and multifrequency electrical impedance spectroscopy (EIS) devices...
April 15, 2024: Scientific Reports
#6
JOURNAL ARTICLE
Alexandra Klein, Katharina Klug, Maximilian Breyer, Julia Grüner, Vijay Krishna Medala, Peter Nordbeck, Christoph Wanner, Eva Klopocki, Nurcan Üçeyler
Fabry disease (FD) is an X-linked multiorgan disorder caused by variants in the alpha-galactosidase A gene (GLA). Depending on the variant, disease phenotypes range from benign to life-threatening. More than 1000 GLA variants are known, but a link between genotype and phenotype in FD has not yet been established for all. p.A143T, p.D313Y, and p.S126G are frequent examples of variants of unknown significance (VUS). We have investigated the potential pathogenicity of these VUS combining clinical data with data obtained in human cellular in vitro systems...
April 15, 2024: Journal of Inherited Metabolic Disease
#7
Tongwu Zhang, Jian Sang, Phuc H Hoang, Wei Zhao, Jennifer Rosenbaum, Kofi Ennu Johnson, Leszek J Klimczak, John McElderry, Alyssa Klein, Christopher Wirth, Erik N Bergstrom, Marcos Díaz-Gay, Raviteja Vangara, Frank Colon-Matos, Amy Hutchinson, Scott M Lawrence, Nathan Cole, Bin Zhu, Teresa M Przytycka, Jianxin Shi, Neil E Caporaso, Robert Homer, Angela C Pesatori, Dario Consonni, Marcin Imielinski, Stephen J Chanock, David C Wedge, Dmitry A Gordenin, Ludmil B Alexandrov, Reuben S Harris, Maria Teresa Landi
APOBEC enzymes are part of the innate immunity and are responsible for restricting viruses and retroelements by deaminating cytosine residues 1,2 . Most solid tumors harbor different levels of somatic mutations attributed to the off-target activities of APOBEC3A (A3A) and/or APOBEC3B (A3B) 3-6 . However, how APOBEC3A/B enzymes shape the tumor evolution in the presence of exogenous mutagenic processes is largely unknown. Here, by combining deep whole-genome sequencing with multi-omics profiling of 309 lung cancers from smokers with detailed tobacco smoking information, we identify two subtypes defined by low ( LAS ) and high ( HAS ) APOBEC mutagenesis...
April 3, 2024: bioRxiv
#8
JOURNAL ARTICLE
Joshua Laß, Theresa Lüth, Kathleen Schlüter, Susen Schaake, Björn-Hergen Laabs, Christoph Much, Roland Dominic Jamora, Raymond L Rosales, Gerard Saranza, Cid Czarina E Diesta, Christopher E Pearson, Inke R König, Norbert Brüggemann, Christine Klein, Ana Westenberger, Joanne Trinh
BACKGROUND: X-Linked dystonia-parkinsonism (XDP) is an adult-onset neurodegenerative disorder characterized by rapidly progressive dystonia and parkinsonism. Mosaic Divergent Repeat Interruptions affecting motif Length and Sequence (mDRILS) were recently found within the TAF1 SVA repeat tract and were shown to associate with repeat stability and age at onset in XDP, specifically the AGGG [5'-SINE-VNTR-Alu(AGAGGG)2 AGGG(AGAGGG)n ] mDRILS. OBJECTIVE: This study aimed to investigate the stability of mDRILS frequencies and stability of (AGAGGG)n repeat length during transmission in parent-offspring pairs...
April 14, 2024: Movement Disorders: Official Journal of the Movement Disorder Society
#9
JOURNAL ARTICLE
Aleksandra Jatkowska, Konstantinos Gkikas, Ben Nichols, Bryn Short, Vasiliki-Konstantina Rizou, Panagiotis Kapranos, Jennifer Klein Gunnewiek, Edelyn Christina, Vaios Svolos, Christopher Quince, Konstantinos Gerasimidis
INTRODUCTION: Enteral nutrition (EN) involves replacing all or part of a person's habitual diet with a nutritional formula. The impact of varying doses of EN on the gut microbiome remains understudied. METHODS: Healthy adults replaced all (100% EN) or part (85% EN, 50% EN and 20% EN) of their energy requirements with EN for 7 days. Faecal samples were collected before and on day 7 of interventions. Faecal pH, short chain fatty acids (SCFAs), branched-chain fatty acids (BCFAs) and 16S rRNA sequencing were performed...
April 9, 2024: Clinical Nutrition
#10
JOURNAL ARTICLE
Piers Klein, Liqi Shu, Erik Lindgren, Maria A de Winter, James E Siegler, Alexis N Simpkins, Satareh Salehi Omran, Mirjam R Heldner, Adam de Havenon, Mohamad Abdalkader, Sami Al Kasab, Christoph Stretz, Teddy Y Wu, Duncan Wilson, Syed Daniyal Asad, Eyad Almallouhi, Jennifer Frontera, Lindsey Kuohn, Aaron Rothstein, Ekaterina Bakradze, Nils Henninger, Adeel S Zubair, Richa Sharma, Deborah Kerrigan, Yasmin Aziz, Eva A Mistry, Mayte Sanchez van Kammen, Turgut Tatlisumak, Katarzyna Krzywicka, Diana Aguiar de Sousa, Katarina Jood, Thalia S Field, Shadi Yaghi, Jonathan M Coutinho, Thanh N Nguyen
OBJECTIVES: Prognostication for cerebral venous thrombosis (CVT) remains difficult. We sought to validate the SI2 NCAL2 C score in an international cohort. MATERIALS AND METHODS: The SI2 NCAL2 C score was originally developed to predict poor outcome (modified Rankin Scale (mRS) 3-6) at 6 months, and mortality at 30 days and 1 year using data from the International CVT Consortium. The SI2 NCAL2 C score uses 9 variables: the absence of any female-sex-specific risk factors, intracerebral hemorrhage, central nervous system infection, focal neurological deficits, coma, age, lower level of hemoglobin, higher level of glucose, and cancer...
April 11, 2024: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
#11
JOURNAL ARTICLE
Christoph-Ferdinand Wielenberg, Johannes Christian Fostitsch, Christian Volz, Reinhard Marks, Kerstin Michalski, Ralph Wäsch, Robert Zeiser, Juri Ruf, Philipp T Meyer, Claudius Klein
Chimeric antigen receptor (CAR) T-cell therapy has dramatically shifted the landscape of treatment especially for Non-Hodgkin-Lymphoma (NHL). This study evaluates the role of fluorodeoxyglucose (FDG)-positron emission tomography/computed tomography (PET/CT) in NHL treated with CAR T-cell therapy concerning response assessment and prognosis.We evaluated 34 patients with NHL who received a CAR T-cell therapy between August 2019 and July 2022. All patients underwent a pre-therapeutic FDG-PET/CT (PET-0) 6 days prior and a post-therapeutic FDG-PET/CT (PET-1) 34 days after CAR T-cell therapy...
April 9, 2024: Nuklearmedizin. Nuclear Medicine
#12
JOURNAL ARTICLE
Katariina Nurmi, Kristiina Silventoinen, Salla Keskitalo, Kristiina Rajamäki, Vesa-Petteri Kouri, Matias Kinnunen, Sami Jalil, Rocio Maldonado, Kirmo Wartiovaara, Elma Inés Nievas, Silvina Paola Denita-Juárez, Christopher J A Duncan, Outi Kuismin, Janna Saarela, Inka Romo, Timi Martelius, Jukka Parantainen, Arzu Beklen, Marcelina Bilicka, Sampsa Matikainen, Dan C Nordström, Meri Kaustio, Ulla Wartiovaara-Kautto, Outi Kilpivaara, Christoph Klein, Fabian Hauck, Tiina Jahkola, Timo Hautala, Markku Varjosalo, Goncalo Barreto, Mikko R J Seppänen, Kari K Eklund
In monogenic autoinflammatory diseases, mutations in genes regulating innate immune responses often lead to uncontrolled activation of inflammasome pathways or the type I interferon (IFN-I) response. We describe a mechanism of autoinflammation potentially predisposing patients to life-threatening necrotizing soft tissue inflammation. Six unrelated families are identified in which affected members present with necrotizing fasciitis or severe soft tissue inflammations. Exome sequencing reveals truncating monoallelic loss-of-function variants of nuclear factor κ light-chain enhancer of activated B cells (NFKB1) in affected patients...
April 3, 2024: Cell reports medicine
#13
JOURNAL ARTICLE
Lisa Monika Klein, Julika Lamp, Christina Schopf, Angelika Miriam Gabler, Florian Kaltner, Claudia Guldimann, Michael Rychlik, Christine Schwake-Anduschus, Karin Knappstein, Christoph Gottschalk
1,2-Dehydro-pyrrolizidine alkaloids (PA), their corresponding N -oxides (PANO) and tropane alkaloids (TA), are toxic plant metabolites. If plant material, containing these toxins, is present in the feed of dairy cows these toxins can be transferred into milk. Here, milk was sampled directly from dairy farms in the German federal states of Bavaria and Schleswig-Holstein in 2020-2022 in order to investigate a possible contamination of milk at the production stage. In total, 228 milk samples were analysed for 54 PA/PANO and two TA by a sensitive LC-ESI-MS/MS method...
April 9, 2024: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
#14
JOURNAL ARTICLE
Antonia Klein, Sarah A Aeschlimann, Frederic Zubler, Adrian Scutelnic, Franz Riederer, Matthias Ertl, Christoph J Schankin
BACKGROUND: Visual snow syndrome is a disorder characterized by the combination of typical perceptual disturbances. The clinical picture suggests an impairment of visual filtering mechanisms and might involve primary and secondary visual brain areas, as well as higher-order attentional networks. On the level of cortical oscillations, the alpha rhythm is a prominent EEG pattern that is involved in the prioritisation of visual information. It can be regarded as a correlate of inhibitory modulation within the visual network...
April 8, 2024: Journal of Headache and Pain
#15
JOURNAL ARTICLE
Matthias Stelljes, Jan Moritz Middeke, Gesine Bug, Eva-Maria Wagner-Drouet, Lutz P Müller, Christoph Schmid, Stefan W Krause, Wolfgang Bethge, Edgar Jost, Uwe Platzbecker, Stefan A Klein, Jörg Schubert, Judith Niederland, Martin Kaufmann, Kerstin Schäfer-Eckart, Markus Schaich, Henning Baldauf, Friedrich Stölzel, Cathleen Petzold, Christoph Röllig, Nael Alakel, Björn Steffen, Beate Hauptrock, Christoph Schliemann, Katja Sockel, Fabian Lang, Oliver Kriege, Judith Schaffrath, Christian Reicherts, Wolfgang E Berdel, Hubert Serve, Gerhard Ehninger, Alexander H Schmidt, Martin Bornhäuser, Jan-Henrik Mikesch, Johannes Schetelig
BACKGROUND: Whether high-dose cytarabine-based salvage chemotherapy, administered to induce complete remission in patients with poor responsive or relapsed acute myeloid leukaemia scheduled for allogeneic haematopoietic stem-cell transplantation (HSCT) after intensive conditioning confers a survival advantage, is unclear. METHODS: To test salvage chemotherapy before allogeneic HSCT, patients aged between 18 and 75 years with non-favourable-risk acute myeloid leukaemia not in complete remission after first induction or untreated first relapse were randomly assigned 1:1 to remission induction with high-dose cytarabine (3 g/m2 intravenously, 1 g/m2 intravenously for patients >60 years or with a substantial comorbidity) twice daily on days 1-3 plus mitoxantrone (10 mg/m2 intravenously) on days 3-5 or immediate allogeneic HSCT for the disease control group...
April 4, 2024: Lancet Haematology
#16
JOURNAL ARTICLE
Tanja C Vallée, Jannik S Glasmacher, Hannes Buchner, Peter D Arkwright, Uta Behrends, Anastasia Bondarenko, Michael J Browning, David K Buchbinder, Alessandro Cattoni, Liudmyla Chernyshova, Peter Ciznar, Theresa Cole, Wojciech Czogala, Gregor Dueckers, John David M Edgar, Fatih Erbey, Anders Fasth, Francesca Ferrua, Renata Formankova, Eleonora Gambineri, Andrew R Gennery, Frederick D Goldman, Luis Ignacio Gonzalez-Granado, Carsten Heilmann, Tarja Heiskanen-Kosma, Hanna Juntti, Leena Kainulainen, Hirokazu Kanegane, Neslihan E Karaca, Sara Sebnem Kilic, Christoph Klein, Sylwia Koltan, Irina Kondratenko, Isabelle Meyts, Gulnara M Nasrullayeva, Lucia Dora Notarangelo, Srdjan Pasic, Isabelle Pellier, Claudio Pignata, Siraj Ahmed Misbah, Ansgar S Schulz, Gesmar Rs Segundo, Anna Shcherbina, Mary A Slatter, Robert Sokolic, Pere Soler-Palacin, Polina Stepensky, Joris M van Montfrans, Samppa Ryhänen, Beata Wolska-Kuśnierz, John B Ziegler, Xiaodong Zhao, Alessandro Aiuti, Hans D Ochs, Michael H Albert
WAS is a multifaceted monogenic disorder with a broad disease spectrum and variable disease severity and a variety of treatment options including allogeneic hematopoietic stem cell transplantation (HSCT) and gene therapy (GT). No reliable biomarker exists to predict disease course and outcome for individual patients. A total of 577 patients with a WAS variant from 26 countries and a median follow-up of 8.9 years (0.3-71.1), totaling 6118 patient-years, were included in this international retrospective study...
April 5, 2024: Blood
#17
JOURNAL ARTICLE
Marion Laurent, Stéphanie Bougeard, Lucile Caradec, Florence Ghestem, Matthias Albrecht, Mark J F Brown, Joachim D E Miranda, Reet Karise, Jessica Knapp, José Serrano, Simon G Potts, Maj Rundlöf, Janine Schwarz, Eleanor Attridge, Aurélie Babin, Irene Bottero, Elena Cini, Pilar D E L A Rúa, Gennaro D I Prisco, Christophe Dominik, Daniel Dzul, Andrés G A R C Í A Reina, Simon Hodge, Alexandra M Klein, Anina Knauer, Marika Mand, Vicente M A R T Í N E Z López, Giorgia Serra, Helena Pereira-Peixoto, Risto Raimets, Oliver Schweiger, Deepa Senapathi, Jane C Stout, Giovanni Tamburini, Cecilia Costa, Tomasz Kiljanek, Anne-Claire Martel, L E Sébastien, Marie-Pierre Chauzat
Declines in insect pollinators have been linked to a range of causative factors such as disease, loss of habitats, the quality and availability of food, and exposure to pesticides. Here, we analysed an extensive dataset generated from pesticide screening of foraging insects, pollen-nectar stores/beebread, pollen and ingested nectar across three species of bees collected at 128 European sites set in two types of crop. In this paper, we aimed to (i) derive a new index to summarise key aspects of complex pesticide exposure data and (ii) understand the links between pesticide exposures depicted by the different matrices, bee species and apple orchards versus oilseed rape crops...
April 1, 2024: Science of the Total Environment
#18
JOURNAL ARTICLE
Guilhem Lalle, Raphaëlle Lautraite, Khaled Bouherrou, Maud Plaschka, Aurora Pignata, Allison Voisin, Julie Twardowski, Marlène Perrin-Niquet, Pierre Stéphan, Sarah Durget, Laurie Tonon, Maude Ardin, Cyril Degletagne, Alain Viari, Laurence Belgarbi Dutron, Nathalie Davoust, Thomas S Postler, Jingyao Zhao, Christophe Caux, Julie Caramel, Stéphane Dalle, Philippe A Cassier, Ulf Klein, Marc Schmidt-Supprian, Roland Liblau, Sankar Ghosh, Yenkel Grinberg-Bleyer
The outcome of cancer and autoimmunity is often dictated by the effector functions of CD4+ conventional T cells (Tconv). Although activation of the NF-κB signaling pathway has long been implicated in Tconv biology, the cell-autonomous roles of the separate NF-κB transcription-factor subunits are unknown. Here, we dissected the contributions of the canonical NF-κB subunits RelA and c-Rel to Tconv function. RelA, rather than c-Rel, regulated Tconv activation and cytokine production at steady-state and was required for polarization toward the TH17 lineage in vitro...
June 3, 2024: Journal of Experimental Medicine
#19
JOURNAL ARTICLE
Benjamin R Clopper, Yingtao Zhou, Ayzsa Tannis, Mary Allen Staat, Marilyn Rice, Julie A Boom, Leila C Sahni, Rangaraj Selvarangan, Christopher J Harrison, Natasha B Halasa, Laura S Stewart, Geoffrey A Weinberg, Peter G Szilagyi, Eileen J Klein, Janet A Englund, Brian Rha, Joana Y Lively, Ismael R Ortega-Sanchez, Meredith L McMorrow, Heidi L Moline
OBJECTIVE: To assess medical costs of hospitalizations and emergency department (ED) care associated with respiratory syncytial virus (RSV) disease in children enrolled in the New Vaccine Surveillance Network. STUDY DESIGN: We used accounting and prospective surveillance data from six pediatric health systems to assess direct medical costs from laboratory-confirmed RSV-associated hospitalizations (n=2,007) and ED visits (n=1,267) from 2016 through 2019 among children aged <5 years...
March 30, 2024: Journal of Pediatrics
#20
JOURNAL ARTICLE
Lea Strohm, Andreas Daiber, Henning Ubbens, Roopesh Krishnankutty, Matthias Oelze, Marin Kuntic, Omar Hahad, Veronique Klein, Imo E Hoefer, Alex von Kriegsheim, Hartmut Kleinert, Dorothee Atzler, Philipp Lurz, Christian Weber, Philipp S Wild, Thomas Münzel, Christoph Knosalla, Esther Lutgens, Steffen Daub
CD40L-CD40-TRAF signaling plays a role in atherosclerosis progression and affects the pathogenesis of coronary heart disease (CHD). We tested the hypothesis that CD40L-CD40-TRAF signaling is a potential therapeutic target in hyperlipidemia, diabetes, and hypertension. In mouse models of hyperlipidemia plus diabetes (db/db mice) or hypertension (1 mg/kg/d angiotensin-II for 7 days), TRAF6 inhibitor treatment (2.5 mg/kg/d for 7 or 14 days) normalized markers of oxidative stress and inflammation...
March 30, 2024: Basic Research in Cardiology
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