Read by QxMD icon Read

Klein Christoph

Jenny L Davies, JaNean K Engelstad, Linde E Gove, Linda K Linbo, Rickey E Carter, Christopher Lynch, Nathan P Staff, Christopher J Klein, P James B Dyck, David N Herrmann, Peter J Dyck
INTRODUCTION: For sequential and somatotopic assessment of small fiber neuropathy (SFN), heat pain (HP) tests of hypoalgesia might be used instead of decreased counts of epidermal nerve fibers (ENFs), but then healthy subject reference values of HP thresholds are needed. METHODS: Using the CASE IVc system, HP thresholds of hypoalgesia were estimated for ten unilateral sites and counts of ENFs for four of them in healthy subjects. RESULTS: In healthy subjects, small but statistically significant differences of both HP thresholds of hypoalgesia and counts of ENFs were observed among tested sites...
March 15, 2018: Muscle & Nerve
Thomas Magg, Tilmann Schober, Christoph Walz, Julia Ley-Zaporozhan, Fabio Facchetti, Christoph Klein, Fabian Hauck
Epstein-Barr virus positive (EBV+ ) smooth muscle tumors (SMTs) constitute a very rare oncological entity. They usually develop in the context of secondary immunodeficiency caused by human immunodeficiency virus infection or immunosuppressive treatment after solid organ transplantation. However, in a small fraction of predominantly pediatric patients, EBV+ SMTs may occur in patients with primary immunodeficiency disorders (PIDs), such as GATA2 and CARMIL2 deficiency. In secondary immunodeficiencies and when the underlying condition can not be cured, the treatment of EBV+ SMTs is based on surgery in combination with antiretroviral and reduced or altered immunosuppressive pharmacotherapy, respectively...
2018: Frontiers in Immunology
Stephanie Stiel, Mareike Nurnus, Christoph Ostgathe, Carsten Klein
BACKGROUND: Clinical practice of Palliative Sedation (PS) varies between institutions worldwide and sometimes includes problematic practices. Little available research points at different definitions and frameworks which may contribute to uncertainty of healthcare professionals in the application of PS. This analysis investigates what demographic factors and characteristics of treatment practices differ between institutions with high versus low sedation rates estimates in Palliative and Hospice Care in Germany...
March 13, 2018: BMC Palliative Care
Joshua T Prickett, Brendan J Klein, Christopher M Busch, Joshua A Cuoco, Lisa S Apfel, Eric A Marvin
Intraventricular meningiomas are uncommon intracranial tumors and infrequently present with hemorrhage. With only 10 reported cases in the literature, it is exceedingly rare for meningiomas of the ventricular system to present with hemorrhage. To our knowledge, this is the first report of a patient presenting with an acute intraventricular hemorrhage in relation to a ventricular meningioma suspected to be radiation induced. In addition, we review the current literature on hemorrhagic intraventricular meningiomas and review the natural history of radiation-induced meningiomas...
January 2018: Journal of Neurological Surgery Reports
Lara B McKenzie, Kristin J Roberts, Roxanne Clark, Rebecca McAdams, Mahmoud Abdel-Rasoul, Elizabeth G Klein, Sarah A Keim, Orie Kristel, Alison Szymanski, Christopher G Cotton, Wendy C Shields
BACKGROUND: Many unintentional injuries that occur in and around the home can be prevented through the use of safety equipment and by consistently following existing safety recommendations. Unfortunately, uptake of these safety behaviors is unacceptably low. This paper describes the design of the Make Safe Happen® smartphone application evaluation study, which aims to evaluate a mobile technology-based safety behavior change intervention on parents' safety knowledge and actions. METHODS: Make Safe Happen® app evaluation study is a randomized controlled trial...
March 12, 2018: Injury Epidemiology
Oliver C Thiele, Matthias Kreppel, Anton Dunsche, Andre M Eckardt, Michael Ehrenfeld, Bernd Fleiner, Volker Gaßling, Gerd Gehrke, Marcus Gerressen, Martin Gosau, Alexander Gröbe, Stefan Haßfeld, Max Heiland, Bodo Hoffmeister, Frank Hölzle, Cornelius Klein, Maximilian Krüger, Alexander C Kübler, Norbert R Kübler, Johannes J Kuttenberger, Constantin Landes, Günter Lauer, Markus Martini, Erich T Merholz, Robert A Mischkowski, Bilal Al-Nawas, Emeka Nkenke, Jörn U Piesold, Winnie Pradel, Michael Rasse, Martin Rachwalski, Rudolf H Reich, Daniel Rothamel, Jan Rustemeyer, Martin Scheer, Henning Schliephake, Rainer Schmelzeisen, Alexander Schramm, Wiebke Schupp, Wolfgang J Spitzer, Erwin Stocker, Christian Stoll, Hendrik Terheyden, Alexander Voigt, Wilfried Wagner, Dieter Weingart, Richard Werkmeister, Jörg Wiltfang, Christoph M Ziegler, Joachim E Zöller
The current surgical techniques used in cleft repair are well established, but different centers use different approaches. To determine the best treatment for patients, a multi-center comparative study is required. In this study, we surveyed all craniofacial departments registered with the German Society of Maxillofacial Surgery to determine which cleft repair techniques are currently in use. Our findings revealed much variation in cleft repair between different centers. Although most centers did use a two-stage approach, the operative techniques and timing of lip and palate closure were different in every center...
February 6, 2018: Journal of Cranio-maxillo-facial Surgery
Christoph Lipps, Franziska Klein, Tom Wahlicht, Virginia Seiffert, Milada Butueva, Jeannette Zauers, Theresa Truschel, Martin Luckner, Mario Köster, Roderick MacLeod, Jörn Pezoldt, Jochen Hühn, Qinggong Yuan, Peter Paul Müller, Henning Kempf, Robert Zweigerdt, Oliver Dittrich-Breiholz, Thomas Pufe, Rainer Beckmann, Wolf Drescher, Jose Riancho, Carolina Sañudo, Thomas Korff, Bertram Opalka, Vera Rebmann, Joachim R Göthert, Paula M Alves, Michael Ott, Roland Schucht, Hansjörg Hauser, Dagmar Wirth, Tobias May
Fundamental research and drug development for personalized medicine necessitates cell cultures from defined genetic backgrounds. However, providing sufficient numbers of authentic cells from individuals poses a challenge. Here, we present a new strategy for rapid cell expansion that overcomes current limitations. Using a small gene library, we expanded primary cells from different tissues, donors, and species. Cell-type-specific regimens that allow the reproducible creation of cell lines were identified. In depth characterization of a series of endothelial and hepatocytic cell lines confirmed phenotypic stability and functionality...
March 8, 2018: Nature Communications
Amar U Kishan, Ryan R Cook, Jay P Ciezki, Ashley E Ross, Mark M Pomerantz, Paul L Nguyen, Talha Shaikh, Phuoc T Tran, Kiri A Sandler, Richard G Stock, Gregory S Merrick, D Jeffrey Demanes, Daniel E Spratt, Eyad I Abu-Isa, Trude B Wedde, Wolfgang Lilleby, Daniel J Krauss, Grace K Shaw, Ridwan Alam, Chandana A Reddy, Andrew J Stephenson, Eric A Klein, Daniel Y Song, Jeffrey J Tosoian, John V Hegde, Sun Mi Yoo, Ryan Fiano, Anthony V D'Amico, Nicholas G Nickols, William J Aronson, Ahmad Sadeghi, Stephen Greco, Curtiland Deville, Todd McNutt, Theodore L DeWeese, Robert E Reiter, Johnathan W Said, Michael L Steinberg, Eric M Horwitz, Patrick A Kupelian, Christopher R King
Importance: The optimal treatment for Gleason score 9-10 prostate cancer is unknown. Objective: To compare clinical outcomes of patients with Gleason score 9-10 prostate cancer after definitive treatment. Design, Setting, and Participants: Retrospective cohort study in 12 tertiary centers (11 in the United States, 1 in Norway), with 1809 patients treated between 2000 and 2013. Exposures: Radical prostatectomy (RP), external beam radiotherapy (EBRT) with androgen deprivation therapy, or EBRT plus brachytherapy boost (EBRT+BT) with androgen deprivation therapy...
March 6, 2018: JAMA: the Journal of the American Medical Association
Shelby Wilson, Edward Dere, David Klein, Christoph Schorl, Susan Hall, Kim Boekelheide
We examined the precise localization of dimethylated histone three lysine four (H3K4me2) in mature rat sperm. Within non-intergenic enriched regions, half of the DNA peaks associated with H3K4me2 retention fell in gene bodies and the other half in promoter regions. The most significant peaks near annotated DNA regions in the composite data included loci known to be associated with RNA metabolism, cell cycle regulation and spermatogenesis. Regions associated with differential retention of H3K4me2 within gene bodies were significantly enriched for housekeeping gene and cell-cycle functionality...
February 28, 2018: Biology of Reproduction
Jakob Neubauer, Matthias Benndorf, Claudia Ehritt-Braun, Kilian Reising, Tayfun Yilmaz, Christopher Klein, Horst Zajonc, Elmar Kotter, Mathias Langer, Sebastian Moritz Goerke
The aim of this study was to evaluate and compare the diagnostic accuracy, the inter-rater agreement and raters' certainty of cone beam computed tomography (CBCT) and radiography for the detection of scaphoid fractures. Our hypothesis is that the CBCT has a higher diagnostic accuracy for scaphoid fractures than radiography. We retrospectively analysed patients who underwent both radiography and CBCT examinations within 4 days to rule out a scaphoid fracture over a 2-year period in our institution. 4 blinded radiologists and orthopaedic surgeons independently rated the images regarding the presence of a scaphoid fracture...
March 2, 2018: Scientific Reports
Jan Vollert, Walter Magerl, Ralf Baron, Andreas Binder, Elena K Enax-Krumova, Gerd Geisslinger, Janne Gierthmühlen, Florian Henrich, Philipp Hüllemann, Thomas Klein, Jörn Lötsch, Christoph Maier, Bruno Oertel, Sigrid Schuh-Hofer, Thomas R Tölle, Rolf-Detlef Treede
As an indirect approach to relate previously identified sensory phenotypes of patients suffering from peripheral neuropathic pain to underlying mechanisms, we used a published sorting algorithm to estimate the prevalence of denervation, peripheral and central sensitization in 657 healthy subjects undergoing experimental models of nerve block (compression block, topical lidocaine), primary (sunburn, topical capsaicin), or secondary hyperalgesia (intradermal capsaicin, electrical high-frequency stimulation), and in 902 patients suffering from neuropathic pain...
February 24, 2018: Pain
Anna Lorentzen, Paul F Becker, Jan Kosla, Massimo Saini, Kathrin Weidele, Paolo Ronchi, Corinna Klein, Monika J Wolf, Felix Geist, Bastian Seubert, Marc Ringelhan, Daniela Mihic-Probst, Knud Esser, Marko Roblek, Felix Kuehne, Gaia Bianco, Tracy O'Connor, Quentin Müller, Kathleen Schuck, Sebastian Lange, Daniel Hartmann, Saskia Spaich, Olaf Groß, Jochen Utikal, Sebastian Haferkamp, Martin R Sprick, Amruta Damle-Vartak, Alexander Hapfelmeier, Norbert Hüser, Ulrike Protzer, Andreas Trumpp, Dieter Saur, Nachiket Vartak, Christoph A Klein, Bernhard Polzer, Lubor Borsig, Mathias Heikenwalder
Dynamic polarisation of tumour cells is essential for metastasis. While the role of polarisation during dedifferentiation and migration is well established, polarisation of metastasising tumour cells during phases of detachment has not been investigated. Here we identify and characterise a type of polarisation maintained by single cells in liquid phase termed single-cell (sc) polarity and investigate its role during metastasis. We demonstrate that sc polarity is an inherent feature of cells from different tumour entities that is observed in circulating tumour cells in patients...
February 28, 2018: Nature Communications
Daniel Kotlarz, Benjamin Marquardt, Tuva Barøy, Way S Lee, Liza Konnikova, Sebastian Hollizeck, Thomas Magg, Anna S Lehle, Christoph Walz, Ingo Borggraefe, Fabian Hauck, Philip Bufler, Raffaele Conca, Sarah M Wall, Eva M Schumacher, Doriana Misceo, Eirik Frengen, Beint S Bentsen, Holm H Uhlig, Karl-Peter Hopfner, Aleixo M Muise, Scott B Snapper, Petter Strømme, Christoph Klein
Transforming growth factor (TGF)-β1 (encoded by TGFB1) is the prototypic member of the TGF-β family of 33 proteins that orchestrate embryogenesis, development and tissue homeostasis1,2 . Following its discovery3 , enormous interest and numerous controversies have emerged about the role of TGF-β in coordinating the balance of pro- and anti-oncogenic properties4,5 , pro- and anti-inflammatory effects6 , or pro- and anti-fibrinogenic characteristics7 . Here we describe three individuals from two pedigrees with biallelic loss-of-function mutations in the TGFB1 gene who presented with severe infantile inflammatory bowel disease (IBD) and central nervous system (CNS) disease associated with epilepsy, brain atrophy and posterior leukoencephalopathy...
February 26, 2018: Nature Genetics
Maria Chondronikola, Faidon Magkos, Jun Yoshino, Adewole L Okunade, Bruce W Patterson, Michael J Muehlbauer, Christopher B Newgard, Samuel Klein
OBJECTIVE: Lactate is an intermediate of glucose metabolism that has been implicated in the pathogenesis of insulin resistance. This study evaluated the relationship between glucose kinetics and plasma lactate concentration ([LAC]) before and after manipulating insulin sensitivity by progressive weight loss. METHODS: Forty people with obesity (BMI = 37.9 ± 4.3 kg/m2 ) were randomized to weight maintenance (n = 14) or weight loss (n = 19). Subjects were studied before and after 6 months of weight maintenance and before and after 5%, 11%, and 16% weight loss...
February 24, 2018: Obesity
Ricardo H Roda, Brett A McCray, Christopher J Klein, Ahmet Hoke
No abstract text is available yet for this article.
February 2018: Neurology. Genetics
Benjamin Ribba, Christophe Boetsch, Tapan K Nayak, Hans Peter Grimm, Jehad M Charo, Stefan Evers, Christian Klein, Jean J L Tessier, Jean Eric Charoin, Alex Phipps, Pavel Pisa, Volker Teichgräber
PURPOSE: Optimal dosing is critical for immunocytokine-based cancer immunotherapy to maximize efficacy and minimize toxicity. Cergutuzumab amunaleukin (CEA-IL2v) is a novel CEA-targeted immunocytokine. We set out to develop a mathematical model to predict intratumoral CEA-IL2v concentrations following various systemic dosing intensities. EXPERIMENTAL DESIGN: Sequential measurements of CEA-IL2v plasma concentrations in 74 patients with solid tumors were applied in a series of differential equations to devise a model that also incorporates the peripheral concentrations of IL-2 receptor-positive cell populations (i...
February 20, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Michael O'Donnell, Leif D Nelson, Evi Ackermann, Balazs Aczel, Athfah Akhtar, Silvio Aldrovandi, Nasseem Alshaif, Ronald Andringa, Mark Aveyard, Peter Babincak, Nursena Balatekin, Scott A Baldwin, Gabriel Banik, Ernest Baskin, Raoul Bell, Olga Białobrzeska, Angie R Birt, Walter R Boot, Scott R Braithwaite, Jessie C Briggs, Axel Buchner, Desiree Budd, Kathryn Budzik, Lottie Bullens, Richard L Bulley, Peter R Cannon, Katarzyna Cantarero, Joseph Cesario, Stephanie Chambers, Christopher R Chartier, Peggy Chekroun, Clara Chong, Axel Cleeremans, Sean P Coary, Jacob Coulthard, Florien M Cramwinckel, Thomas F Denson, Marcos Díaz-Lago, Theresa E DiDonato, Aaron Drummond, Julia Eberlen, Titus Ebersbach, John E Edlund, Katherine M Finnigan, Justin Fisher, Natalia Frankowska, Efraín García-Sánchez, Frank D Golom, Andrew J Graves, Kevin Greenberg, Mando Hanioti, Heather A Hansen, Jenna A Harder, Erin R Harrell, Andree Hartanto, Michael Inzlicht, David J Johnson, Andrew Karpinski, Victor N Keller, Olivier Klein, Lina Koppel, Emiel Krahmer, Anthony Lantian, Michael J Larson, Jean-Baptiste Légal, Richard E Lucas, Dermot Lynott, Corey M Magaldino, Karlijn Massar, Matthew T McBee, Neil McLatchie, Nadhilla Melia, Michael C Mensink, Laura Mieth, Samantha Moore-Berg, Geraldine Neeser, Ben R Newell, Marret K Noordewier, Asil Ali Özdogğru, Myrto Pantazi, Michał Parzuchowski, Kim Peters, Michael C Philipp, Monique M H Pollmann, Panagiotis Rentzelas, Rosa Rodríguez-Bailón, Jan Philipp Röer, Ivan Ropovik, Nelson A Roque, Carolina Rueda, Bastiaan T Rutjens, Katey Sackett, Janos Salamon, Ángel Sánchez-Rodríguez, Blair Saunders, Juliette Schaafsma, Michael Schulte-Mecklenbeck, David R Shanks, Martin F Sherman, Kenneth M Steele, Niklas K Steffens, Jessie Sun, Kyle J Susa, Barnabas Szaszi, Aba Szollosi, Ricardo M Tamayo, Gustav Tinghög, Yuk-Yue Tong, Carol Tweten, Miguel A Vadillo, Deisy Valcarcel, Nicolas Van der Linden, Michiel van Elk, Frenk van Harreveld, Daniel Västfjäll, Simine Vazire, Philippe Verduyn, Matt N Williams, Guillermo B Willis, Sarah E Wood, Chunliang Yang, Oulmann Zerhouni, Robert Zheng, Mark Zrubka
Dijksterhuis and van Knippenberg (1998) reported that participants primed with a category associated with intelligence ("professor") subsequently performed 13% better on a trivia test than participants primed with a category associated with a lack of intelligence ("soccer hooligans"). In two unpublished replications of this study designed to verify the appropriate testing procedures, Dijksterhuis, van Knippenberg, and Holland observed a smaller difference between conditions (2%-3%) as well as a gender difference: Men showed the effect (9...
February 1, 2018: Perspectives on Psychological Science: a Journal of the Association for Psychological Science
Livio Mordasini, Carlo Di Bona, Jacques Klein, Agostino Mattei, Gregory Wirth, Christophe E Iselin
OBJECTIVES: To assess long term functional and safety follow-up data after 80-W GreenLight photoselective vaporization (GL PV) of the prostate and transurethral resection of the prostate (TURP). MATERIALS AND METHODS: Prospective randomized trial at a single tertiary referral center (Geneva, Switzerland). Patients were recruited in the outpatient clinic if they met the criteria for surgical treatment of BPO. At baseline, 238 patients were treated either with the 80-W GL PV or monopolar TURP...
February 12, 2018: Urology
Arya Shah, E Matthew Hoffman, Michelle L Mauermann, Charles L Loprinzi, Anthony J Windebank, Christopher J Klein, Nathan P Staff
OBJECTIVE: To assess disease burden of chemotherapy-induced peripheral neuropathy (CIPN), which is a common dose-limiting side effect of neurotoxic chemotherapy. Late effects of CIPN may increase with improved cancer survival. METHODS: Olmsted County, Minnesota residents receiving neurotoxic chemotherapy were identified and CIPN was ascertained via text searches of polyneuropathy symptoms in the medical record. Clinical records were queried to collect data on baseline characteristics, risk factors, signs and symptoms of CIPN, medications, impairments and International Classification of Diseases, Ninth Revision (ICD-9) diagnostic codes for all subjects...
February 8, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
Julienne M Jagdeo, Antoine Dufour, Theo Klein, Nestor Solis, Oded Kleifeld, Jayachandran Kizhakkedathu, Honglin Luo, Christopher M Overall, Eric Jan
Enteroviruses encode proteinases that are essential for processing of the translated viral polyprotein. In addition, viral proteinases also target host proteins to manipulate cellular processes and evade innate antiviral responses to promote replication and infection. Although some host protein substrates of enterovirus proteinases have been identified, the full repertoire of targets remains unknown. We used a novel quantitative in vitro proteomics-based approach, termed<u>t</u>erminal<u>a</u>mine<u>i</u>sotopic<u>l</u>abeling of<u>s</u>ubstrates (TAILS), to identify with high confidence 72 and 34 new host protein targets of poliovirus and coxsackievirus B3 (CVB3) 3C proteinases (3C pro ) in HeLa cell and cardiomyocyte HL-1 cell lysates, respectively...
February 7, 2018: Journal of Virology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"