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Klein Christoph

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https://www.readbyqxmd.com/read/29786793/a-method-for-prostate-and-breast-cancer-cell-spheroid-cultures-using-gelatin-methacryloyl-based-hydrogels
#1
Christoph Meinert, Christina Theodoropoulos, Travis J Klein, Dietmar W Hutmacher, Daniela Loessner
Modern tissue engineering technologies have delivered tools to recreate a cell's naturally occurring niche in vitro and to investigate normal and pathological cell-cell and cell-niche interactions. Hydrogel biomaterials mimic crucial properties of native extracellular matrices, including mechanical support, cell adhesion sites and proteolytic degradability. As such, they are applied as 3D cell culture platforms to replicate tissue-like architectures observed in vivo, allowing physiologically relevant cell behaviors...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29776470/clinical-outcomes-of-anconeus-interposition-arthroplasty-after-radial-head-resection-in-native-and-prosthetic-radial-heads
#2
Hithem Rahmi, Julie A Neumann, Christopher Klein, Carola F van Eck, Brian K Lee, John Itamura
BACKGROUND: Radiocapitellar pathology after traumatic injury to the elbow can be challenging to treat. The anconeus interposition arthroplasty has been proposed to treat radiocapitellar or proximal radioulnar joint dysfunction and pain, or both. This study evaluated whether radial head excision (native or prosthetic), followed by an anconeus interposition arthroplasty, relieves pain and improves subjective and objective elbow function in patients with post-traumatic radiocapitellar pathology...
June 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29767955/low-cost-efficient-and-durable-h-2-production-by-photoelectrochemical-water-splitting-with-cuga-3-se-5-photocathodes
#3
Christopher P Muzzillo, W Ellis Klein, Zhen Li, Alexander Daniel DeAngelis, Kimberly Horsley, Kai Zhu, Nicolas Gaillard
Photoelectrochemical (PEC) water-splitting is an elegant method of converting sunlight and water into H2 fuel. To be commercially advantageous, PEC devices must become cheaper, more efficient and much more durable. This work examines low-cost polycrystalline chalcopyrite films, which are successful as photovoltaic absorbers, for application as PEC absorbers. In particular, Cu-Ga-Se films with wide band gaps can be employed as top cell photocathodes in tandem devices as a realistic route to high efficiencies...
May 16, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29761127/elevated-lgi1-igg-csf-index-predicts-worse-neurological-outcome
#4
Avi Gadoth, Anastasia Zekeridou, Christopher J Klein, Colton J Thoreson, Masoud Majed, Divyanshu Dubey, Eoin P Flanagan, Andrew McKeon, Sarah M Jenkins, Vanda A Lennon, Sean J Pittock
To determine whether CSF leucine-rich glioma-inactivated 1(LGI1)-IgG titer, index or IgG subclass has prognostic significance, we tested serum and CSF specimens collected concomitantly from 39 seropositive patients. LGI1-IgG index was elevated (>1) in 21 patients (54%), suggesting intrathecal synthesis. Patients with worse outcome at last follow-up (modified Rankin Scale >2) had significantly higher index (median 6.57 vs. 0.5, P  = 0.048) compared to those with better outcome. Higher CSF LGI1-IgG4 subclass-specific titer and index correlated with worse outcome ( P  < 0...
May 2018: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29735745/control-of-mitotic-chromosome-condensation-by-the-fission-yeast-transcription-factor-zas1
#5
Christoph Schiklenk, Boryana Petrova, Marc Kschonsak, Markus Hassler, Carlo Klein, Toby J Gibson, Christian H Haering
Although the formation of rod-shaped chromosomes is vital for the correct segregation of eukaryotic genomes during cell divisions, the molecular mechanisms that control the chromosome condensation process have remained largely unknown. Here, we identify the C2 H2 zinc-finger transcription factor Zas1 as a key regulator of mitotic condensation dynamics in a quantitative live-cell microscopy screen of the fission yeast Schizosaccharomyces pombe By binding to specific DNA target sequences in their promoter regions, Zas1 controls expression of the Cnd1 subunit of the condensin protein complex and several other target genes, whose combined misregulation in zas1 mutants results in defects in chromosome condensation and segregation...
May 7, 2018: Journal of Cell Biology
https://www.readbyqxmd.com/read/29725080/publisher-correction-single-cell-gene-expression-reveals-a-landscape-of-regulatory-t-cell-phenotypes-shaped-by-the-tcr
#6
David Zemmour, Rapolas Zilionis, Evgeny Kiner, Allon M Klein, Diane Mathis, Christophe Benoist
In the version of this article initially published, the Supplementary Note was missing. The Supplementary Note has now been provided online and is cited in the Methods section of the article. The error has been corrected in the HTML and PDF version of the article.
May 3, 2018: Nature Immunology
https://www.readbyqxmd.com/read/29721166/isolated-metastasis-of-an-egfr-l858r-mutated-nsclc-of-the-meninges-the-potential-impact-of-cxcl12-cxcr4-axis-in-egfr-mut-nsclc-in-diagnosis-follow-up-and-treatment
#7
Florian Lüke, Raquel Blazquez, Rezan Fahrioglu Yamaci, Xin Lu, Benedikt Pregler, Stefan Hannus, Karin Menhart, Dirk Hellwig, Hans-Jürgen Wester, Saskia Kropf, Daniel Heudobler, Jirka Grosse, Jutta Moosbauer, Markus Hutterer, Peter Hau, Markus J Riemenschneider, Michaela Bayerlová, Annalen Bleckmann, Bernhard Polzer, Tim Beißbarth, Christoph A Klein, Tobias Pukrop
Brain and leptomeningeal metastasis (LMM) of non-small cell lung cancer is still associated with poor prognosis. Moreover, the current diagnostic standard for LMM often yields false negative results and the scientific progress in this field is still unsatisfying. We present a case of a 71-year old patient with an isolated LMM. While standard diagnostics could only diagnose a cancer of unknown primary, the use of [68 Ga]-Pentixafor-PET/CT (CXCR4-PET/CT, a radiotracer targeting CXCR4) and a liquid biopsy of the cerebrospinal fluid revealed the primary NSCLC...
April 10, 2018: Oncotarget
https://www.readbyqxmd.com/read/29720090/sulphite-oxidase-so-a-mitochondrial-autoantigen-as-target-for-humoral-and-cellular-immune-reactions-in-primary-sclerosing-cholangitis
#8
Beate E Preuß, Christoph P Berg, Christoph Werner, Sandra Plankenhorn, Nisar P Malek, Reinhild Klein
BACKGROUND: In a recent study we had evidence that sulphite oxidase (SO) may be a relevant autoantigen in primary sclerosing cholangitis (PSC). Aim of the present study was, therefore, to analyse humoral and cellular immune-reactivity towards SO in these patients in more detail. METHODS: Sera from 53 patients with PSC (30 untreated and 23 treated with ursodeoxycholic acid [UDCA] at time of analysis), from 422 patients with different hepatic and non-hepatic disorders, and from 50 healthy individuals were tested by ELISA for antibodies against full-length-SO (SO-fl) and its three major domains expressed in E...
May 2, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29719034/measuring-functional-status-in-hospitalized-older-adults-through-electronic-health-record-documentation
#9
Liron Sinvani, Andrzej Kozikowski, Vidhi Patel, Colm Mulvany, Christopher Smilios, Guang Qiu, Meng Zhang, Gisele Wolf-Klein, Renee Pekmezaris
OBJECTIVES: Hospitalization-associated disability affects up to 60% of older adults; however, standardized measures of function are not routinely used and documented. We sought to determine whether nursing documentation in electronic medical records can be used to determine mobility status and associated clinical outcomes. METHODS: A retrospective study of 2383 medical patients aged 75 years and older was conducted at a large academic tertiary hospital in New York...
April 2018: Southern Medical Journal
https://www.readbyqxmd.com/read/29716742/climate-velocity-can-inform-conservation-in-a-warming-world
#10
REVIEW
Isaac Brito-Morales, Jorge García Molinos, David S Schoeman, Michael T Burrows, Elvira S Poloczanska, Christopher J Brown, Simon Ferrier, Tom D Harwood, Carissa J Klein, Eve McDonald-Madden, Pippa J Moore, John M Pandolfi, James E M Watson, Amelia S Wenger, Anthony J Richardson
Climate change is shifting the ranges of species. Simple predictive metrics of range shifts such as climate velocity, that do not require extensive knowledge or data on individual species, could help to guide conservation. We review research on climate velocity, describing the theory underpinning the concept and its assumptions. We highlight how climate velocity has already been applied in conservation-related research, including climate residence time, climate refugia, endemism, historic and projected range shifts, exposure to climate change, and climate connectivity...
April 28, 2018: Trends in Ecology & Evolution
https://www.readbyqxmd.com/read/29715594/involvement-of-neural-crest-and-paraxial-mesoderm-in-oral-mucosal-development-and-healing
#11
Juliane Isaac, Ali Nassif, Audrey Asselin, Ihsène Taïhi, Hélène Fohrer-Ting, Christophe Klein, Bruno Gogly, Ariane Berdal, Benoît Robert, Benjamin P Fournier
Tissue engineering therapies using adult stem cells derived from neural crest have sought accessible tissue sources of these cells because of their potential pluripotency. In this study, the gingiva and oral mucosa and their associated stem cells were investigated. Biopsies of these tissues produce neither scarring nor functional problems and are relatively painless, and fresh tissue can be obtained readily during different chairside dental procedures. However, the embryonic origin of these cells needs to be clarified, as does their evolution from the perinatal period to adulthood...
April 21, 2018: Biomaterials
https://www.readbyqxmd.com/read/29712816/teaching-video-neuroimages-acquired-focal-neuromyotonia-in-lgi-1-autoimmunity
#12
A Sebastian López Chiriboga, Joseph Matsumoto, Eric Sorenson, Christopher J Klein, Andrew McKeon
No abstract text is available yet for this article.
May 1, 2018: Neurology
https://www.readbyqxmd.com/read/29691970/scai-consensus-guidelines-for-device-selection-in-femoral-popliteal-arterial-interventions
#13
Dmitriy N Feldman, Ehrin J Armstrong, Herbert D Aronow, Osvaldo S Gigliotti, Michael R Jaff, Andrew J Klein, Sahil A Parikh, Anand Prasad, Kenneth Rosenfield, Mehdi H Shishehbor, Rajesh V Swaminathan, Christopher J White
No abstract text is available yet for this article.
April 24, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29676777/do-not-resuscitate-orders-in-older-adults-during-hospitalization-a-propensity-score-matched-analysis
#14
Karishma Patel, Liron Sinvani, Vidhi Patel, Andrzej Kozikowski, Christopher Smilios, Meredith Akerman, Kinga Kiszko, Sutapa Maiti, Negin Hajizadeh, Gisele Wolf-Klein, Renee Pekmezaris
OBJECTIVES: To explore the effect of the presence and timing of a do-not-resuscitate (DNR) order on short-term clinical outcomes, including mortality. DESIGN: Retrospective cohort study with propensity score matching to enable direct comparison of DNR and no-DNR groups. SETTING: Large, academic tertiary-care center. PARTICIPANTS: Hospitalized medical patients aged 65 and older. MEASUREMENTS: Primary outcome was in-hospital mortality...
April 20, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29669919/mutations-in-the-pancreatic-secretory-enzymes-cpa1-and-cpb1-are-associated-with-pancreatic-cancer
#15
Koji Tamura, Jun Yu, Tatsuo Hata, Masaya Suenaga, Koji Shindo, Toshiya Abe, Anne MacGregor-Das, Michael Borges, Christopher L Wolfgang, Matthew J Weiss, Jin He, Marcia Irene Canto, Gloria M Petersen, Steven Gallinger, Sapna Syngal, Randall E Brand, Anil Rustgi, Sara H Olson, Elena Stoffel, Michele L Cote, George Zogopoulos, James B Potash, Fernando S Goes, Richard W McCombie, Peter P Zandi, Mehdi Pirooznia, Melissa Kramer, Jennifer Parla, James R Eshleman, Nicholas J Roberts, Ralph H Hruban, Alison Patricia Klein, Michael Goggins
To evaluate whether germline variants in genes encoding pancreatic secretory enzymes contribute to pancreatic cancer susceptibility, we sequenced the coding regions of CPB1 and other genes encoding pancreatic secretory enzymes and known pancreatitis susceptibility genes ( PRSS1 , CPA1 , CTRC , and SPINK1 ) in a hospital series of pancreatic cancer cases and controls. Variants in CPB1 , CPA1 (encoding carboxypeptidase B1 and A1), and CTRC were evaluated in a second set of cases with familial pancreatic cancer and controls...
April 18, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29660604/response-time-distribution-parameters-show-posterror-behavioral-adjustment-in-mental-arithmetic
#16
Dmitri Lavro, Danny Levin, Christoph Klein, Andrea Berger
After making an error, we usually slow down before our next response. This phenomenon is known as the posterror slowing (PES) effect. It has been interpreted to be an indicator of posterror behavioral adjustments and, therefore, has been linked to cognitive control. However, contradictory findings regarding PES and posterror accuracy cast doubt on such a relation. To determine whether behavior is adjusted after making an error, we investigated other features of behavior, such as the distribution of response times (RT) in a mental arithmetic task...
April 13, 2018: Acta Psychologica
https://www.readbyqxmd.com/read/29658909/pretreatment-with-argon-protects-human-cardiac-myocyte-like-progenitor-cells-from-oxygen-glucose-deprivation-induced-cell-death-by-activation-of-akt-and-differential-regulation-of-mapkinases
#17
Hong Qi, Lourdes Soto-Gonzalez, Konstantin A Krychtiuk, Sarah Ruhittel, Christoph Kaun, Walter S Speidl, Attila Kiss, Bruno K Podesser, Shanglong Yao, Klaus Markstaller, Klaus U Klein, Verena Tretter
BACKGROUND: The noble gas argon induces cardioprotection in a rabbit model of myocardial ischemia and reperfusion. However, no studies in human primary cells or subjects have been performed so far. We used human cardiac myocyte-like progenitor cells (HCMs) to investigate the protective effect on the cellular level. METHODS: HCMs were pretreated with 30% or 50% argon before oxygen-glucose deprivation (OGD) and reperfusion. We evaluated apoptotic states by flow cytometry and the activation of mitogen-activated protein kinase (MAPKs) members extracellular signal-regulated kinase (ERK), c-jun N-terminal kinase (JNK), p38 MAPkinase, and protein kinase B (Akt) by Westernblot analysis and by activity assays of downstream transcription factors...
May 2018: Shock
https://www.readbyqxmd.com/read/29649601/adjuvant-non-bacteriolytic-and-anti-inflammatory-combination-therapy-in-pneumococcal-meningitis-an-investigation-in-a-mouse-model
#18
M Klein, C Höhne, B Angele, T Högen, H W Pfister, H Tüfekci, U Koedel
OBJECTIVES: Therapy with antibiotics, dexamethasone, and supportive intensive care has improved the prognosis of pneumococcal meningitis, but mortality remains high. Here, we investigated an adjunctive combination therapy of the non-bacteriolytic antibiotic daptomycin plus several anti-inflammatory agents to identify the currently most promising adjunctive combination therapy for pneumococcal meningitis. METHODS: C57BL/6 mice were infected by injection of pneumococci into the cisterna magna...
April 9, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29648834/importance-of-post-translational-modifications-in-the-interaction-of-proteins-with-mineral-surfaces-the-case-of-arginine-methylation-and-silica-surfaces
#19
Laurent Marichal, Jean-Philippe Renault, Stephane Chedin, Gilles Lagniel, Géraldine Klein, Jean-Christophe Aude, Carine Tellier-Lebegue, Jean Armengaud, Serge Pin, Jean Labarre, Yves Boulard
Understanding the mechanisms involved in the interaction of proteins with inorganic surfaces is of major interest for both basic research and practical applications involving nanotechnology. From the list of cellular proteins with the highest affinity for silica nanoparticles, we highlighted the group of proteins containing RGG motifs. Biochemical experiments confirmed that RGG motifs interact strongly with silica surfaces. The affinity of these motifs is further increased when the R residue is asymmetrically, but not symmetrically, dimethylated...
April 12, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29642419/treatment-of-multidrug-resistant-leukemia-cells-by-novel-artemisinin-egonol-and-thymoquinone-derived-hybrid-compounds
#20
Lisa Gruber, Sara Abdelfatah, Tony Fröhlich, Christoph Reiter, Volker Klein, Svetlana B Tsogoeva, Thomas Efferth
Two major obstacles for successful cancer treatment are the toxicity of cytostatics and the development of drug resistance in cancer cells during chemotherapy. Acquired or intrinsic drug resistance is responsible for almost 90% of treatment failure. For this reason, there is an urgent need for new anticancer drugs with improved efficacy against cancer cells, and with less toxicity on normal cells. There are impressive examples demonstrating the success of natural plant compounds to fight cancer, such as Vinca alkaloids, taxanes, and anthracyclines...
April 6, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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