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curcumin and cancer

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https://www.readbyqxmd.com/read/29792799/in-vivo-evaluation-of-reduction-responsive-alendronate-hyaluronan-curcumin-polymer-drug-conjugates-for-targeted-therapy-of-bone-metastatic-breast-cancer
#1
Kaili Wang, Chunjing Guo, Xue Dong, Yueming Yu, Bingjie Wang, Wanhui Liu, Daquan Chen
Many cancers such as human breast cancer and lung cancer easily metastasize to bones, leading to the formation of secondary tumors in advanced stage. Based on the CD44-targeted effect of oHA and bone-targeted effect of ALN, we prepared a reduction-responsive, CD44 receptor-targeting and bone-targeting nano-micelle, called CUR-loaded ALN-oHA-S-S-CUR micelles. In this study, we aimed to evaluate the antitumor activity and bone-targeting ability of CUR-loaded ALN-oHA-S-S-CUR micelles. The in vivo experiment results showed that a larger number of micelles was gathered in the bone metastatic tumor tissue and reduced the bone destruction...
May 24, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29790797/curcumin-loaded-redox-responsive-mesoporous-silica-nanoparticles-for-targeted-breast-cancer-therapy
#2
Nana Li, Zhi Wang, Yongtai Zhang, Kai Zhang, Jianxu Xie, Ying Liu, Wansi Li, Nianping Feng
HYPOTHESIS: The antitumor applications of curcumin (CUR) are limited because of its low water solubility, poor stability, and low bioavailability. We developed novel nanocarrier systems for tumour targeting and controlled CUR release and evaluated their therapeutic efficacy. EXPERIMENTS: The surface of mesoporous silica nanoparticles (MSN) was modified with hyaluronan (HA) or polyethyleneimine-folic acid (PEI-FA) via disulfide bonds. The capacity of the resultant nanocarriers (MSN-HA and MSN-PEI-FA, respectively) for CUR delivery was evaluated in a breast cancer cell line and a mouse xenograft model...
May 23, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29790012/evaluation-of-a-nanocomposite-of-peg-curcumin-gold-nanoparticles-as-a-near-infrared-photothermal-agent-an-in-vitro-and-animal-model-investigation
#3
F Rahimi-Moghaddam, N Azarpira, N Sattarahmady
Hyperthermia is a promising alternative modality for the conventional cancer treatments. Nanoparticle-mediated photothermal therapy (PTT) has been widely applied for hyperthermia cancer therapy by a near-infrared light irradiation. Some special nanoparticles can convert light energy into heat and destroy the tumor cells. Inspired from the photothermal efficacy of the gold nanoparticles, here we synthesized, characterized, and applied novel photothermal polyethylene glycol-curcumin-gold nanoparticles (PEG-Cur-Au NPs) in cancer PTT...
May 22, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29788875/anti-cancer-and-radio-sensitizing-effects-of-curcumin-in-nasopharyngeal-carcinoma
#4
Amir Abbas Momtazi, Faezeh Ghasemi, Amirreza Hesari, Muhammed Majeed, Michele Caraglia, Amirhossein Sahebkar
Nasopharyngeal cancer (NPC) is a rare type of head and neck cancer that is mainly treated by radiotherapy, but sometimes it is radioresistant. Curcumin is a polyphenolic natural product with established anti-cancer effects in various human cancers. Recent studies have shown that curcumin has therapeutic and radio-sensitizing effects on NPC cells. In fact, it has been found that curcumin can sensitize NPC cells to radiation through different mechanisms, including modulation of ROS generation, Jab1/CSN5 and non-coding RNAs...
May 21, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29788873/one-molecule-many-targets-and-numerous-effects-the-pleiotropy-of-curcumin-lies-in-its-chemical-structure
#5
Mahdi Hatamipour, Thomas P Johnston, Amirhossein Sahebkar
Curcumin quite possibly represents one of the most diverse therapeutic agents yet isolated from natural sources. Therapeutic benefits of this extraordinary natural compound have been demonstrated during treatment of a variety of diseases, including cancer, inflammatory processes, immunological disorders, diabetes, and oxidative stress often associated with hyperlipidemia. Due to its unique molecular chemical structure and functional groups, curcumin may bind with and subsequently either inhibit or activate a variety of endogenous biomolecules, including enzymes, receptors, signaling molecules, metals, transcription factors, and even certain proteins located in cell membranes...
May 21, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29787434/influence-of-confounding-factors-on-radiation-dose-estimation-using-in-vivo-validated-transcriptional-biomarkers
#6
Lourdes Cruz-Garcia, Grainne O'Brien, Ellen Donovan, Lone Gothard, Sue Boyle, Antoine Laval, Isabelle Testard, Lucyna Ponge, Grzegorz Woźniak, Leszek Miszczyk, Serge M Candéias, Elizabeth Ainsbury, Piotr Widlak, Navita Somaiah, Christophe Badie
For triage purposes following a nuclear accident, blood-based gene expression biomarkers can provide rapid dose estimates for a large number of individuals. Ionizing-radiation-responsive genes are regulated through the DNA damage-response pathway, which includes activation of multiple transcription factors. Modulators of this pathway could potentially affect the response of these biomarkers and consequently compromise accurate dose estimation calculations. In the present study, four potential confounding factors were selected: cancer condition, sex, simulated bacterial infection (lipopolysaccharide), and curcumin, an anti-inflammatory/antioxidant agent...
July 2018: Health Physics
https://www.readbyqxmd.com/read/29785173/phytochemicals-that-influence-gut-microbiota-as-prophylactics-and-for-the-treatment-of-obesity-and-inflammatory-diseases
#7
REVIEW
Lucrecia Carrera-Quintanar, Rocío I López Roa, Saray Quintero-Fabián, Marina A Sánchez-Sánchez, Barbara Vizmanos, Daniel Ortuño-Sahagún
Gut microbiota (GM) plays several crucial roles in host physiology and influences several relevant functions. In more than one respect, it can be said that you "feed your microbiota and are fed by it." GM diversity is affected by diet and influences metabolic and immune functions of the host's physiology. Consequently, an imbalance of GM, or dysbiosis, may be the cause or at least may lead to the progression of various pathologies such as infectious diseases, gastrointestinal cancers, inflammatory bowel disease, and even obesity and diabetes...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29783629/encapsulation-of-gold-nanostructures-and-oil-in-water-nanocarriers-in-microgels-with-biomedical-potential
#8
Mariela Inostroza-Riquelme, Andrea Vivanco, Pablo Lara, Simón Guerrero, Edison Salas-Huenuleo, Alejandro Chamorro, Lisette Leyton, Karen Bolaños, Eyleen Araya, Andrew F G Quest, Marcelo J Kogan, Felipe Oyarzun-Ampuero
Here we report the incorporation of gold nanostructures (nanospheres or nanorods, functionalized with carboxylate-end PEG) and curcumin oil-in-water (O/W) nanoemulsions (CurNem) into alginate microgels using the dripping technique. While gold nanostructures are promising nanomaterials for photothermal therapy applications, CurNem possess important pharmacological activities as reported here. In this sense, we evaluated the effect of CurNem on cell viability of both cancerous and non-cancerous cell lines (AGS and HEK293T, respectively), demonstrating preferential toxicity in cancer cells and safety for the non-cancerous cells...
May 18, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29781009/electrically-controlled-drug-release-using-ph-sensitive-polymer-films
#9
S Ephraim Neumann, Christian F Chamberlayne, Richard N Zare
Drug delivery systems (DDS) that allow spatially and temporally controlled release of drugs are of particular interest in the field of drug delivery. These systems create opportunities for individually tailored doses of drugs to be administered as well as reduce side effects by localizing the initial drug dose to the organ of interest. We present an electroresponsive DDS in the form of a bioresorbable nanocomposite film which operates at low voltages (<-2 V). The method is based on electrochemically generating local pH changes at an electrode surface to induce dissolution of a pH-sensitive polymer, which is used as the carrier material...
May 21, 2018: Nanoscale
https://www.readbyqxmd.com/read/29778842/curcumin-attenuates-sepsis-induced-acute-organ-dysfunction-by-preventing-inflammation-and-enhancing-the-suppressive-function-of-tregs
#10
Longwang Chen, Yang Lu, Linjun Zhao, Lili Hu, Qiaomeng Qiu, Zhuoling Zhang, Mengfang Li, Guangliang Hong, Bing Wu, Guangju Zhao, Zhongqiu Lu
Sepsis is characterized by the extensive release of cytokines and other mediators. It results in a dysregulated immune response and can lead to organ damage and death. Curcumin has anti-inflammatory properties and immunoregulation functions in various disorders such as sepsis, cancer, rheumatoid arthritis, cardiovascular diseases, lung fibrosis, gallstone formation, and diabetes. This paper investigates the effects of curcumin on immune status and inflammatory response in mice subjected to cecal ligation and puncture (CLP)...
May 17, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29777940/curcumin-attenuates-cerebral-ischemia-injury-in-sprague-dawley-rats-and-pc12-cells-by-suppressing-overactivated-autophagy
#11
Yan Zhang, Ming Fang, Yameng Sun, Ting Zhang, Nan Shi, Jinfeng Li, Lei Jin, Kangyong Liu, Jianliang Fu
The present study assessed whether the protective effects of curcumin against cerebral ischemia injury were due to the suppression of overactivated autophagy. Curcumin is a well-known natural polyphenolic compound that effectively counteracts oxidation, inflammation, and various types of cancer. Several studies have demonstrated the protective effects of curcumin against ischemia-reperfusion injury in tissues from the lungs, cardiomyocytes, and liver. The present study employed brain injury models induced by middle cerebral artery occlusion (MCAO) in rats and PC12 oxygen-glucose-deprived (OGD) cells...
May 7, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29771485/dual-sensitive-hydrogel-nanoparticles-based-on-conjugated-thermoresponsive-copolymers-and-protein-filaments-for-triggerable-drug-delivery
#12
Roujin Ghaffari, Niloofar Eslahi, Elnaz Tamjid, Abdolreza Arash Simchi
Novel hydrogel nanoparticles with dual triggerable release properties based on fibrous structural proteins (Keratin) and thermoresponsive copolymers (Pluronic) is introduced. The nanoparticle was used for Curcumin delivery, as an effective and safe anticancer agent, hydrophobicity of which has limited its clinical application. The drug was loaded into hydrogel nanoparticles by a single-step nanoprecipitation method. The drug-loaded nanoparticles had an average dimeter of 165 nm and 66 nm at 25ºC and 37ºC, respectively...
May 17, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29771044/-the-role-of-autophagy-in-the-curcumin-induced-proliferation-in-human-laryngeal-cancer-hep2-cell
#13
B L Wan, T T Yan, Y J Zhang, X T Li
Objective: The aim of this study is to study the effect of 3-methyladenine (3-MA) on the autophagy and apoptosis of human laryngeal cancer Hep 2 cells induced by curcumin. Method: The proliferation of human laryngeal cancer Hep2 cells was observed by MTT assay. The autophagy level was detected by AO acridine orange staining. Annexin VFITC/PI double staining was used to detect the apoptosis of Hep2 cells. The expression of LC3, Beclin1, Bcl-2 and Bax protein were detected by Western blot. Result: MTT assay showed that curcumin inhibited the proliferation of Hep2 cells in a dose/time dependent manner...
May 20, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29770869/curcumin-inhibits-autocrine-growth-hormone-mediated-invasion-and-metastasis-by-targeting-nf-%C3%AE%C2%BAb-signaling-and-polyamine-metabolism-in-breast-cancer-cells
#14
Ajda Coker-Gurkan, Merve Celik, Merve Ugur, Elif-Damla Arisan, Pinar Obakan-Yerlikaya, Zeynep Begum Durdu, Narcin Palavan-Unsal
Curcumin is assumed to be a plant-derived therapeutic drug that triggers apoptotic cell death in vitro and in vivo by affecting different molecular targets such as NF-κB. Phase I/II trial of curcumin alone or with chemotherapeutic drugs has been accomplished in pancreatic, colon, prostate and breast cancer cases. Recently, autocrine growth hormone (GH) signaling-induced cell growth, metastasis and drug resistance have been demonstrated in breast cancer. In this study, our aim was to investigate the potential therapeutic effect of curcumin by evaluating the molecular machinery of curcumin-triggered apoptotic cell death via focusing on NF-κB signaling and polyamine (PA) metabolism in autocrine GH-expressing MCF-7, MDA-MB-453 and MDA-MB-231 breast cancer cells...
May 16, 2018: Amino Acids
https://www.readbyqxmd.com/read/29768014/hybrid-mesoporous-microporous-nanocarriers-for-overcoming-multidrug-resistance-by-sequential-drug-delivery
#15
Liucan Wang, Haidi Guan, Zhenqiang Wang, Yuxin Xing, Jixi Zhang, Kaiyong Cai
Combination chemotherapy with a modulator and a chemotherapeutic drug has become one of the most promising strategies for the treatment of multidrug resistance (MDR) in cancer therapy. However, the development of nanocarriers with a high payload and sequential release of therapeutic agents poses a significant challenge. In this work, we report a type of hybrid nanocarriers prepared by polydopamine (PDA) mediated integration of the mesoporous MSN core and the microporous zeolite imidazolate frameworks-8 (ZIF-8) shell...
May 16, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29766185/the-curcumin-derivative-wz35-activates-ros-dependent-jnk-to-suppress-hepatocellular-carcinoma-metastasis
#16
Lihua Wang, Lijie Han, Zheying Tao, Zheng Zhu, Lei Han, Zhenfei Yang, Hao Wang, Dandan Dai, Liang Wu, Zhengzhong Yuan, Tongke Chen
Tumor metastasis is the leading cause of cancer death; due to the progress made in the elucidation of the mechanism of cancer cell metastasis, there is hope for patients with severe stages of cancer. Curcumin, as a novel anti-cancer drug, has been applied in cancer therapy; however, the toxicity of curcumin hinders its application. Herein, we constructed a novel derivative, WZ35, and evaluated its metastatic inhibition properties in vitro and in vivo. CCK-8 assay was performed to evaluate the tumor suppressive activity of WZ35...
May 16, 2018: Food & Function
https://www.readbyqxmd.com/read/29765996/an-in-vitro-study-on-curcumin-delivery-by-nano-micelles-for-esophageal-squamous-cell-carcinoma-kyse-30
#17
Sare Hosseini, Jamshidkhan Chamani, Hamidreza Rahimi, Navid Azmoodeh, Faezeh Ghasemi, Porya Hassan Abadi
Background: The incidence of esophageal squamous cell carcinoma (ESCC) is increasing, causing catastrophic health burdens on communities. Curcumin has shown promise as a therapeutic agent in the treatment of colon, colorectal, pancreatic, and esophageal cancers but it has very poor bioavailability. The application of nano-carriers as drug delivery systems increases curcumin's bioavailability. Cyclin D1 is overexpressed in ESCC and curcumin may change its expression. Methods: In this study, the effect of SinaCurcumin®, a novel nano-micelle product containing 80 mg curcumin, on the growth of KYSE-30 cells and expression of cyclin D1, was investigated...
April 2018: Reports of Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/29762477/characterization-of-curcumin-cyclodextrin-polymer-inclusion-complex-and-investigation-on-its-antioxidant-and-antiproliferative-activities
#18
Jianping Chen, Xiaoming Qin, Saiyi Zhong, Suhua Chen, Weiming Su, Ying Liu
The aims of this study were to characterize the curcumin/cyclodextrin polymer inclusion complex using X-ray diffractometry (XRD), Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and UV⁻vis spectroscopy, and to determine the antioxidant activity of this complex by methods of scavenging 2,2-azinobis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radicals assays and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals assays. The inhibitory effect of inclusion complex on A375 cells was also investigated by CCK-8 assay, Annexin-V/PI staining assay, and caspase activity assay...
May 15, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29759562/investigational-agents-to-enhance-the-efficacy-of-chemotherapy-or-radiation-in-pancreatic-cancer
#19
REVIEW
Myrna Hurtado, Umesh T Sankpal, Amalendu Ranjan, Rajasekhar Maram, Jamboor K Vishwanatha, Ganji Purnachandra Nagaraju, Bassel F El-Rayes, Riyaz Basha
Pancreatic cancer (PC) continues to be a fatal malignancy. With standard treatments having modest impact, alternative courses of actions are being investigated such as enhancing the efficacy of standard treatment through sensitization of PC cells to chemotherapy or radiation. This review emphasizes investigational agents that increase the responses to chemotherapy or radiation in PC models. Our group has extensively investigated on Curcumin (Cur), analogs (EF31, UBS109, and L49H37), nanoparticles and a small molecule Tolfenamic acid (TA) for enhancing therapeutic efficacy in both in vitro and in vivo assays...
June 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29755534/nano-packaged-tamoxifen-and-curcumin-effective-formulation-against-sensitive-and-resistant-mcf-7-cells
#20
Samira Hajigholami, Ziba Veisi Malekshahi, Narges Bodaghabadi, Farhod Najafi, Hadi Shirzad, Majid Sadeghizadeh
Tamoxifen is routinely used for treatment of Estrogen-positive breast carcinoma. Approximately, 50% of patients with metastatic cancer will develop resistance to Tamoxifen. In this research, Tamoxifen was combined with the anti-cancer compound Curcumin. Diblocknanopolymer was used to package the new formulation of Curcumin and Tamoxifen. Anti-cancer efficacy of the obtained compound was evaluated in Tamoxifen-sensitive (TS). MCF-7, Tamoxifen-resistant (TR) MCF-7 cancer cells and Fibroblast cells. MTT assay was used to evaluate anti-proliferation and toxicity...
2018: Iranian Journal of Pharmaceutical Research: IJPR
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