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curcumin and cancer

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https://www.readbyqxmd.com/read/28210221/pharmacogenomic-characterization-and-isobologram-analysis-of-the-combination-of-ascorbic-acid-and-curcumin-two-main-metabolites-of-curcuma-longa-in-cancer-cells
#1
Edna Ooko, Onat Kadioglu, Henry J Greten, Thomas Efferth
Curcuma longa has long been used in China and India as anti-inflammatory agent to treat a wide variety of conditions and also as a spice for varied curry preparations. The chemoprofile of the Curcuma species exhibits the presence of varied phytochemicals with curcumin being present in all three species but AA only being shown in C. longa. This study explored the effect of a curcumin/AA combination on human cancer cell lines. The curcumin/AA combination was assessed by isobologram analysis using the Loewe additivity drug interaction model...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28199187/combinatorial-effect-of-curcumin-with-docetaxel-modulates-apoptotic-and-cell-survival-molecules-in-prostate-cancer
#2
Saswati Banerjee, Santosh K Singh, Indrajit Chowdhury, Rajesh Singh
Docetaxel is the most commonly used chemotherapeutic agent to target androgen signaling in metastatic prostate cancer (PCa); however, prolonged treatment with docetaxel results in drug-resistant cancer cells. Combination therapies have the potential of increasing the effectiveness of drug treatment as well as decreasing the side effects. Curcumin is a nontoxic organic compound with multifaceted chemopreventive potential. In this study, we evaluated whether curcumin can reinforce the effect of docetaxel on PCa cells...
March 1, 2017: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/28199114/curcumin-loaded-blood-stable-polymeric-micelles-for-enhancing-therapeutic-effect-on-erythroleukemia
#3
Feirong Gong, Dan Chen, Xin Teng, Junhua Ge, Xianfeng Ning, Ya-Ling Shen, Jian Li, Shanfeng Wang
Curcumin has high potential in suppressing many types of cancer and overcoming multi-drug resistance in a multi-faceted manner by targeting diverse molecular targets. However, the rather low systemic bioavailability resulted from its extremely low aqueous solubility and rapid metabolism and excretion in vivo has hampered its application in cancer therapy. With the primary aim to increase the aqueous solubility of curcumin while retaining its stability in the blood circulation before it accesses the tumor site, here we report preparation of curcumin-loaded N-(tert-butoxycarbonyl)-L-phenylalanine end-capped methoxy-poly(ethylene glycol)-block-poly(ε-caprolactone) (mPEG-PCL-Phe(Boc)) micelles with high stability both in vitro and in vivo and anti-tumor efficacy...
February 15, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28198062/curcumin-suppresses-lung-cancer-stem-cells-via-inhibiting-wnt-%C3%AE-catenin-and-sonic-hedgehog-pathways
#4
Jian-Yun Zhu, Xue Yang, Yue Chen, Ye Jiang, Shi-Jia Wang, Yuan Li, Xiao-Qian Wang, Yu Meng, Ming-Ming Zhu, Xiao Ma, Cong Huang, Rui Wu, Chun-Feng Xie, Xiao-Ting Li, Shan-Shan Geng, Jie-Shu Wu, Cai-Yun Zhong, Hong-Yu Han
Cancer stem cells (CSCs) are highly implicated in the progression of human cancers. Thus, targeting CSCs may be a promising strategy for cancer therapy. Wnt/β-catenin and Sonic Hedgehog pathways play an important regulatory role in maintaining CSC characteristics. Natural compounds, such as curcumin, possess chemopreventive properties. However, the interventional effect of curcumin on lung CSCs has not been clarified. In the present study, tumorsphere formation assay was used to enrich lung CSCs from A549 and H1299 cells...
February 15, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28190385/evidence-of-pkc-binding-and-translocation-to-explain-the-anticancer-mechanism-of-chlorogenic-acid-in-breast-cancer-cells
#5
S J Deka, S Gorai, D Manna, V Trivedi
Chlorogenic acid (CGA) exhibits potentials towards liver, breast and skin cancer. Cancer cells stimulated with CGA exhibits differential expression of transcriptional factors and regulatory molecules but the molecular target of the molecule is not known. Superposition of biophoric elements of CGA with Curcumin gives maximum common substructure score of 0.90. Molecular modeling studies further suggest that CGA fits into the C1b domain of PKC with extensive interaction with residues lining binding site. It binds PKC in a concentration dependent manner with dissociation constant KD, 28...
February 9, 2017: Current Molecular Medicine
https://www.readbyqxmd.com/read/28188823/hepatic-stellate-cell-interferes-with-nk-cell-regulation-of-fibrogenesis-via-curcumin-induced-senescence-of-hepatic-stellate-cell
#6
Huanhuan Jin, Yan Jia, Zhen Yao, Jingjing Huang, Meng Hao, Shunyu Yao, Naqi Lian, Feng Zhang, Chenxi Zhang, Xingran Chen, Mianli Bian, Jiangjuan Shao, Li Wu, Anping Chen, Shizhong Zheng
Hepatic fibrosis, a common scarring response to various forms of chronic liver injury, is a precursor to cirrhosis and liver cancer. During liver fibrosis, hepatic stellate cells (HSCs) initially activate and proliferate, which are responsible for the secretion of extracellular matrix components. However, these cells eventually senesce and are cleared by natural killer (NK) cells. Our previous researches have shown that the natural product curcumin could promote the senescence of activated HSC. In this study, we investigated how NK cells target senescent HSC and assessed the effect of this process on liver fibrosis...
February 7, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28187956/cytotoxic-and-apoptotic-effects-of-the-combination-of-palladium-ii-5-5-diethylbarbiturate-complex-with-bis-2-pyridylmethyl-amine-and-curcumin-on-non-small-lung-cancer-cell-lines
#7
Duygu Tunc, Egemen Dere, Didem Karakas, Buse Cevatemre, Veysel Turan Yilmaz, Engin Ulukaya
Metal-based chemotherapeutics such as cisplatin are widely used treatment of lung cancer which is the major cause of cancer-related mortality worldwide. Recent studies demonstrated that novel metal-based compounds have strong cytotoxic activity in a similar way as cisplatin. Therefore, metal-based compounds have been synthesized and investigated in order to determine their cytotoxic activities. It has been also reported curcumin, which has been derived from turmeric plant, has powerful cytotoxic effect on various cancer cell lines...
January 28, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28186369/synthesis-and-mechanistic-studies-of-curcumin-analogs-based-oximes-as-potential-anticancer-agents
#8
Hua-Li Qin, Jing Leng, Bahaa G M Youssif, Muhammad Wahab Amjad, Maria Abdul Ghafoor Raja, Muhammad Ajaz Hussain, Zahid Hussain, Syeda Naveed Kazmi, Syed Nasir Abbas Bukhari
The incidence of cancer can be decreased by chemoprevention using either natural or synthetic agents. Apart from synthetic compounds, numerous natural products have exhibited promising potential to inhibit carcinogenesis in vivo. In this study, α, β-unsaturated carbonyl based anticancer compounds were used as starting materials to synthesize new oxime analogs. The findings from the antiproliferative assay using seven different human cancer cell lines provided a clear picture of structure-activity relationship...
February 10, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28185862/targeting-mirnas-by-polyphenols-novel-therapeutic-strategy-for-cancer
#9
REVIEW
Kasi Pandima Devi, Tamilselvam Rajavel, Maria Daglia, Seyed Fazel Nabavi, Anupam Bishayee, Seyed Mohammad Nabavi
In the recent years, polyphenols have gained significant attention in scientific community owing to their potential anticancer effects against a wide range of human malignancies. Epidemiological, clinical and preclinical studies have supported that daily intake of polyphenol-rich dietary fruits have a strong co-relationship in the prevention of different types of cancer. In addition to direct antioxidant mechanisms, they also regulate several therapeutically important oncogenic signaling and transcription factors...
February 6, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/28182160/curcumin-coordinated-nanoparticles-with-improved-stability-for-reactive-oxygen-species-responsive-drug-delivery-in-lung-cancer-therapy
#10
Cheng-Qiong Luo, Lei Xing, Peng-Fei Cui, Jian-Bin Qiao, Yu-Jing He, Bao-An Chen, Liang Jin, Hu-Lin Jiang
BACKGROUND: The natural compound curcumin (Cur) can regulate growth inhibition and apoptosis in various cancer cell lines, although its clinical applications are restricted by extreme water insolubility and instability. To overcome these hurdles, we fabricated a Cur-coordinated reactive oxygen species (ROS)-responsive nanoparticle using the interaction between boronic acid and Cur. MATERIALS AND METHODS: We synthesized a highly biocompatible 4-(hydroxymethyl) phenylboronic acid (HPBA)-modified poly(ethylene glycol) (PEG)-grafted poly(acrylic acid) polymer (PPH) and fabricated a Cur-coordinated ROS-responsive nanoparticle (denoted by PPHC) based on the interaction between boronic acid and Cur...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28179291/synergistic-inhibitory-effect-of-traditional-chinese-medicine-astragaloside-iv-and-curcumin-on-tumor-growth-and-angiogenesis-in-an-orthotopic-nude-mouse-model-of-human-hepatocellular-carcinoma
#11
Shuo Zhang, Decai Tang, Wenhua Zang, Gang Yin, Jianguo Dai, Y U Sun, Zhijian Yang, Robert M Hoffman, Xiuxia Guo
AIM: The aim of the present study was to investigate the efficacy of the traditional Chinese medicine (TCM), astragaloside IV (AS-IV) and curcumin on tumor growth and angiogenesis in an orthotopic nude-mouse model of human hepatocellular carcinoma (HCC). We have previously shown the usefulness of orthotopic models of human cancer for evaluation of the efficacy of TCM. MATERIALS AND METHODS: Nude mice with orthotopic HepG2 HCC were treated with vehicle control (0...
2017: Anticancer Research
https://www.readbyqxmd.com/read/28176943/silence-of-long-noncoding-rna-pandar-switches-low-dose-curcumin-induced-senescence-to-apoptosis-in-colorectal-cancer-cells
#12
Tao Chen, Peng Yang, Hui Wang, Zhen-Yu He
Long noncoding RNAs (lncRNAs) are emerging as having multiple roles in cancer progression. However, roles of lncRNAs in chemotherapy for colorectal cancer (CRC) remain unclear. This study investigated the biological functions of lncRNA PANDAR in CRC cells treated with curcumin chemotherapy. Herein, we identified that PANDAR expression was not notably differential in CRC tissues compared with the corresponding normal tissues. Consistently, in vitro experiments revealed that knockdown of PANDAR could not change the proliferation, apoptosis, or senescence of CRC cells...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28175963/curcumin-suppresses-cisplatin-resistance-development-partly-via-modulating-extracellular-vesicle-mediated-transfer-of-meg3-and-mir-214-in-ovarian-cancer
#13
Jing Zhang, Jinyu Liu, Xinyan Xu, Li Li
PURPOSE: To investigate how curcumin alters the extracellular vesicles' (EVs) capability to ship drug resistance in ovarian cancer. METHODS: The EVs from cisplatin-resistant A2780cp cells with curcumin treatment (EVs-CU) or without curcumin treatment (EVs-N) were collected for lncRNA profiling. Curcumin's effect on MEG3 promoter methylation and MEG3 expression were studied by MSP and qRT-PCR, respectively. The regulative effect of MEG3 on miR-214 expression and the functional role of EVs mediated transfer of miR-214 in cisplatin resistance were further investigated...
February 8, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28167449/curcumin-and-treatment-of-melanoma-the-potential-role-of-micrornas
#14
REVIEW
Diana Lelli, Claudio Pedone, Amirhosssein Sahebkar
Melanoma is the most aggressive type of skin cancer and is characterized by poor prognosis in its advanced stages because treatments are poorly effective and burdened with severe adverse effects. MicroRNAs (miRNAs) are small non-coding RNAs that are implicated in several cellular processes; they are categorized as oncogenic and tumor suppressor miRNAs. Several miRNAs are implicated in the pathogenesis and progression of melanoma, such as the tumor suppressor miR-let7b that targets cyclin D and regulates cell cycle...
February 3, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28165402/inhibition-of-cell-survival-by-curcumin-is-associated-with-downregulation-of-cell-division-cycle-20-cdc20-in-pancreatic-cancer-cells
#15
Yu Zhang, Ying-Bo Xue, Hang Li, Dong Qiu, Zhi-Wei Wang, Shi-Sheng Tan
Pancreatic cancer is one of the most aggressive human tumors in the United States. Curcumin, a polyphenol derived from the Curcuma longa plant, has been reported to exert its antitumor activity in pancreatic cancer. However, the molecular mechanisms of curcumin-mediated tumor suppressive function have not been fully elucidated. In the current study, we explore whether curcumin exhibits its anti-cancer function through inhibition of oncoprotein cell division cycle 20 (Cdc20) in pancreatic cancer cells. We found that curcumin inhibited cell growth, enhanced apoptosis, induced cell cycle arrest and retarded cell invasion in pancreatic cancer cells...
February 4, 2017: Nutrients
https://www.readbyqxmd.com/read/28160777/curcumin-decreases-malignant-characteristics-of-glioblastoma-stem-cells-via-induction-of-reactive-oxygen-species
#16
Zachary C Gersey, Gregor A Rodriguez, Eric Barbarite, Anthony Sanchez, Winston M Walters, Kelechi C Ohaeto, Ricardo J Komotar, Regina M Graham
BACKGROUND: Glioblastoma Multiforme (GBM) is the most common and lethal form of primary brain tumor in adults. Following standard treatment of surgery, radiation and chemotherapy, patients are expected to survive 12-14 months. Theorized cause of disease recurrence in these patients is tumor cell repopulation through the proliferation of treatment-resistant cancer stem cells. Current research has revealed curcumin, the principal ingredient in turmeric, can modulate multiple signaling pathways important for cancer stem cell self-renewal and survival...
February 4, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28156175/docosahexaenoic-acid-mediated-targeted-and-sustained-brain-delivery-of-curcumin-microemulsion
#17
Rajshree L Shinde, Padma V Devarajan
We disclose microemulsions (ME) of curcumin (CUR) with docosahexaenoic acid (DHA)-rich oil (CUR DHA ME) for targeted delivery to the brain. MEs of CUR (5 mg/mL) with and without DHA-rich oil (CUR Capmul ME) suitable for intravenous and intranasal administration exhibited negative zeta potential, globule size  <20 nm and good stability. Following intravenous delivery MEs exhibited high brain concentration with CUR DHA ME exhibiting a 2.8-fold higher Cmax than CUR solution. Furthermore, high and sustained concentration was demonstrated even at 24 h, which was 8- and 2-fold higher than CUR solution and CUR Capmul ME, respectively...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28156164/cholesterol-conjugated-poly-d-l-lactide-based-micelles-as-a-nanocarrier-system-for-effective-delivery-of-curcumin-in-cancer-therapy
#18
Preeti Kumari, Omkara Swami Muddineti, Sri Vishnu Kiran Rompicharla, Pratyusha Ghanta, Adithya Karthik B B N, Balaram Ghosh, Swati Biswas
Polymeric micelles have been widely explored preclinically as suitable delivery systems for poorly soluble chemotherapeutic drugs in cancer therapy. The present study reported the development of cholesterol (Ch)-conjugated poly(D,L-Lactide) (PLA)-based polymeric micelles (mPEG-PLA-Ch) for effective encapsulation and delivery of curcumin (CUR) at the tumor site. Cholesterol conjugation dramatically affected the particle size and improved drug loading (DL) and encapsulation efficiency (EE). mPEG-PLA-Ch-CUR showed bigger hydrodynamic diameter (104...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28155567/high-drug-payload-curcumin-nanosuspensions-stabilized-by-mpeg-dspe-and-spc-in-vitro-and-in-vivo-evaluation
#19
Jingyi Hong, Yingying Liu, Yao Xiao, Xiaofeng Yang, Wenjing Su, Mingzhu Zhang, Yonghong Liao, Haixue Kuang, Xiangtao Wang
CONTEXT: Curcumin (CUR) is a promising drug candidate based on its broad bioactivities and good antitumor effect, but the application of CUR is potentially restricted because of its poor solubility and bioavailability. OBJECTIVE: This study aims at developing a simple and effective drug delivery system for CUR to enhance its solubility and bioavailability thus to improve its antitumor efficacy. MATERIALS AND METHODS: Curcumin nanosuspensions (CUR-NSps) were prepared by precipitation-ultrasonication method using mPEG2000-DSPE and soybean lecithin as a combined stabilizer...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28152473/combination-of-arabinogalactan-and-curcumin-induces-apoptosis-in-breast-cancer-cells-in-vitro-and-inhibits-tumor-growth-via-overexpression-of-p53-level-in-vivo
#20
Hassan Moghtaderi, Houri Sepehri, Farnoosh Attari
PURPOSE: Increased mortality associated with breast cancer in women has spurred the studies to develop new drugs. Arabinogalactan (AG) and curcumin (Cur) are two natural products broadly explored in cancer therapy. Our major goal in the current study was to assess anticancer properties of combination these reagents in vitro on human breast cancer cells and in vivo utilizing animal model of breast cancer. EXPERIMENTAL DESIGN: We evaluated cell proliferation, apoptosis, cell cycle, and protein expression in vitro on MDA-MB-231 human breast cancer cells...
January 29, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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