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curcumin and cancer

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https://www.readbyqxmd.com/read/29332583/eating-green-shining-light-on-the-use-of-dietary-phytochemicals-as-a-modern-approach-in-the-prevention-and-treatment-of-head-and-neck-cancers
#1
Linda L Eastham, Candace M Howard, Premalatha Balachandran, David S Pasco, Pier Paolo Claudio
Enthusiasm for the use of dietary bioactive compounds as chemopreventive agents and adjuvants for current therapies has increased laboratory research conducted on several types of cancers including Head and Neck Squamous Cell Carcinoma (HNSCC). The green chemoprevention movement is a modern approach to highlight healthy lifestyle changes that aim to decrease the incidence of HNSCC. A healthy diet can be an effective way to prevent the development of oral cancers. Discovery of the naturally occurring plant based compounds called phytochemicals has facilitated the development of new treatment strategies for patients that are at risk for, or have developed HNSCC...
January 12, 2018: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/29332042/protective-effects-of-indian-spice-curcumin-against-amyloid-%C3%AE-in-alzheimer-s-disease
#2
P Hemachandra Reddy, Maria Manczak, Xiangling Yin, Mary Catherine Grady, Andrew Mitchell, Sahil Tonk, Chandra Sekhar Kuruva, Jasvinder Singh Bhatti, Ramesh Kandimalla, Murali Vijayan, Subodh Kumar, Rui Wang, Jangampalli Adi Pradeepkiran, Gilbert Ogunmokun, Kavya Thamarai, Kandi Quesada, Annette Boles, Arubala P Reddy
The purpose of our article is to assess the current understanding of Indian spice, curcumin, against amyloid-β (Aβ)-induced toxicity in Alzheimer's disease (AD) pathogenesis. Natural products, such as ginger, curcumin, and gingko biloba have been used as diets and dietary supplements to treat human diseases, including cancer, cardiovascular, respiratory, infectious, diabetes, obesity, metabolic syndromes, and neurological disorders. Products derived from plants are known to have protective effects, including anti-inflammatory, antioxidant, anti-arthritis, pro-healing, and boosting memory cognitive functions...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29328421/antitumor-activity-of-curcumin-by-modulation-of-apoptosis-and-autophagy-in-human-lung-cancer-a549-cells-through-inhibiting-pi3k-akt-mtor-pathway
#3
Furong Liu, Song Gao, Yuxuan Yang, Xiaodan Zhao, Yameng Fan, Wenxia Ma, Danrong Yang, Aimin Yang, Yan Yu
Curcumin is known to exhibit anticancer effects on various cancers with selective cytotoxicity in tumor cells. In the present study, the effects of curcumin‑induced multiple PCDs on human non‑small cell lung cancer (NSCLC) cells and the potential molecular mechanisms of apoptosis and autophagy triggered by curcumin via the PI3K/Akt/mTOR signaling pathway were explored, further confirmed by co‑culture of curcumin with mTOR blocker rapamycin and PI3K/Akt inhibitor LY294002. The anti‑proliferation effect of different stimulus was measured by MTT assay...
January 4, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29323877/curcumin-conjugated-gold-clusters-for-bioimaging-and-anticancer-applications
#4
Saravanan Govindaraju, Arunkumar Rengaraj, Roshini Arivazhagan, Yun-Suk Huh, Kyusik Yun
Curcumin-conjugated gold clusters (CUR-AuNCs) were synthesized using a "green" procedure and utilized as an anticancer and a bioimaging agent. Curcumin is a well-known anticancer agent, which forms a cluster when reacting with a gold precursor under mild alkali condition. A fluorescence spectroscopy analysis showed that the CUR-AuNCs emitted red fluorescence (650 nm) upon visible light (550) irradiation. Fourier transform infrared spectroscopy analysis confirmed the stretching and bending nature between the gold atoms and curcumin...
January 11, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29320951/glutathione-conjugated-polyethylenimine-on-the-surface-of-fe3o4-magnetic-nanoparticles-as-a-theranostic-agent-for-targeted-and-controlled-curcumin-delivery
#5
Navid Aeineh, Fahimeh Salehi, Mohammad Akrami, Firouzeh Nemati, Masoumeh Alipour, Milad Ghorbani, Banafsheh Nikfar, Fatemeh Salehian, Nader Riyahi Alam, Seyed Esmaeil Sadat Ebrahimi, Alireza Foroumadi, Mehdi Khoobi, Mohammadreza Rouini, Maryam Dibaei, Ismaeil Haririan, Mohammad Reza Ganjali, Saeed Safaei
Theranostics with the ability to simultaneous monitoring of treatment progress and controlled delivery of therapeutic agents has become as an emerging therapeutic paradigm in cancer therapy. In this study, we have developed a novel surface functionalized iron oxide nanoparticle using polyethyleneimine (PEI) and glutathione (GSH) for targeted curcumin (CUR) delivery and acceptable pH sensitive character. The developed magnetic nanoparticles (MNPs) were physicochemically characterized by FT-IR, XRD, FE-SEM and TEM...
January 11, 2018: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/29316620/could-aspirin-and-diets-high-in-fiber-act-synergistically-to-reduce-the-risk-of-colon-cancer-in-humans
#6
REVIEW
Pan Pan, Yi-Wen Huang, Kiyoko Oshima, Martha Yearsley, Jianying Zhang, Jianhua Yu, Mark Arnold, Li-Shu Wang
Early inhibition of inflammation suppresses the carcinogenic process. Aspirin is the most commonly used non-steroid anti-inflammatory drugs (NSAIDs), and it irreversibly inhibits cyclooxygenase-1 and -2 (COX1, COX2). Multiple randomized clinical trials have demonstrated that aspirin offers substantial protection from colon cancer mortality. The lower aspirin doses causing only minimal gastrointestinal disturbance, ideal for long-term use, can achieve only partial and transitory inhibition of COX2. Aspirin's principal metabolite, salicylic acid, is also found in fruits and vegetables that inhibit COX2...
January 6, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29312556/improving-anti-melanoma-effect-of-curcumin-by-biodegradable-nanoparticles
#7
Bilan Wang, Xiaoxiao Liu, Yan Teng, Ting Yu, Junli Chen, Yuzhu Hu, Na Liu, Lingli Zhang, Yangmei Shen
Melanoma is known as the most common malignant cutaneous cancer. Curcumin, a natural component, has been shown to have various activities such as anti-oxidant, anti-septic, anti-inflammatory, anti-biotic, anti-amyloid and anti-thrombosis. However, there is a greatest obstacle in the administration of curcumin due to its hydrophobicity and low oral bioavailability. In this study, we formulated curcumin-loaded MPEG-PLA (Curcumin/MPEG-PLA) micelles aiming to improve its solubility in aqueous solution and investigated anti-tumor effect on melanoma in vitro and in vivo...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29312546/curcumin-downregulates-the-expression-of-snail-via-suppressing-smad2-pathway-to-inhibit-tgf-%C3%AE-1-induced-epithelial-mesenchymal-transitions-in-hepatoma-cells
#8
Meng-Ting Cao, Hui-Fang Liu, Zhi-Gang Liu, Ping Xiao, Jing-Jing Chen, Yuan Tan, Xiao-Xin Jiang, Zhi-Chao Jiang, Yu Qiu, Hong-Jun Huang, Qiu-Gui Zhang, Guan-Min Jiang
Hepatocellular carcinoma (HCC) remains the third cause of cancer-related mortality. Resection and transplantation are the only curative treatments available but are greatly hampered by high recurrence rates and development of metastasis, the initiation of cancer metastasis requires migration and invasion of cells, which is enabled by epithelial-mesenchymal transitions (EMT). TGF-β1 is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29303982/curcumin-analog-dk1-induces-apoptosis-in-human-osteosarcoma-cells-in-vitro-through-mitochondria-dependent-signaling-pathway
#9
Muhammad Nazirul Mubin Aziz, Yazmin Hussin, Nurul Fattin Che Rahim, Noraini Nordin, Nurul Elyani Mohamad, Swee Keong Yeap, Chean Yeah Yong, Mas Jaffri Masarudin, Yoke Kqueen Cheah, Nadiah Abu, Muhammad Nadeem Akhtar, Noorjahan Banu Alitheen
Osteosarcoma is one of the primary malignant bone tumors that confer low survival rates for patients even with intensive regime treatments. Therefore, discovery of novel anti-osteosarcoma drugs derived from natural products that are not harmful to the normal cells remains crucial. Curcumin is one of the natural substances that have been extensively studied due to its anti-cancer properties and is pharmacologically safe considering its ubiquitous consumption for centuries. However, curcumin suffers from a poor circulating bioavailability, which has led to the development of a chemically synthesized curcuminoid analog, namely (Z)-3-hydroxy-1-(2-hydroxyphenyl)-3-phenylprop-2-en-1-one (DK1)...
January 5, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29301415/ph-sensitive-polymeric-nanoparticles-of-mpeg-plga-pglu-with-hybrid-core-for-simultaneous-encapsulation-of-curcumin-and-doxorubicin-to-kill-the-heterogeneous-tumour-cells-in-breast-cancer
#10
Jian-Dong Yuan, De-Li ZhuGe, Meng-Qi Tong, Meng-Ting Lin, Xia-Fang Xu, Xing Tang, Ying-Zheng Zhao, He-Lin Xu
Most breast tumours are heterogeneous and not only contain the bulk of differentiated tumour cells but also a small population of highly tumorigenic and intrinsically drug-resistant cancer stem cells (CSCs). Herein, a pH-sensitive nanoparticle with simultaneous encapsulation of curcumin and doxorubicin (CURDOX-NPs) was prepared by using monomethoxy (polyethylene glycol)-b-P (D,L-lactic-co-glycolic acid)-b-P (L-glutamic acid) polymer to simultaneously target the differentiated tumor cells and CSCs. CURDOX-NPs had a mean diameter of 107...
January 4, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29300102/curcumin-and-melanoma-from-chemistry-to-medicine
#11
Seyed Mohammad Nabavi, Gian Luigi Russo, Idolo Tedesco, Maria Daglia, Ilkay Erdogan Orhan, Seyed Fazel Nabavi, Anupam Bishayee, Kalyan C Nagulapalli Venkata, Mohammad Abdollahi, Zohreh Hajheydari
Melanoma is the most deadly form of skin cancer, with about 48,000 deaths each year worldwide. Growing evidence suggests that individual nutrients or dietary patterns might have important roles in the prevention of melanoma. Considering that melanoma is a potentially life-threatening cancer, novel protective and adjuvant treatments are needed to improve its prognosis. Curcumin is a bioactive substance extracted from rhizome of Curcuma longa L. Its global market is expected to grow in the next few years, especially in the pharmaceutical industry, due to its numerous physiological and pharmacological properties...
January 4, 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29297700/breast-cancer-cell-apoptosis-is-synergistically-induced-by-curcumin-trastuzumab-and-glutathione-peroxidase-1-but-robustly-inhibited-by-glial-cell-line-derived-neurotrophic-factor
#12
M Gardaneh, S Shojaei, A Rahimi Shamabadi, P Akbari
We hypothesized that synergy between curcumin (CURC), trastuzumab (TZMB), and glutathione peroxidase-1 (GPX-1) accelerates breast cancer (BC) cell apoptosis which is inhibited by glial cell line-derived neurotrophic factor (GDNF). We measured survival of BC cell lines treated or cotreated with CURC and TZMB, and then with GDNF, before measuring expression levels of growth and apoptosis genes. These experiments were also repeated on SKBR3 cells transiently expressing GPX-1. CURC+TZMB cotreatment induced BC cell apoptosis more significantly than single treatment...
January 3, 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29296172/folic-acid-conjugation-improves-the-bioavailability-and-chemosensitizing-efficacy-of-curcumin-encapsulated-plga-peg-nanoparticles-towards-paclitaxel-chemotherapy
#13
Arun Kumar T Thulasidasan, Archana P Retnakumari, Mohan Shankar, Vinod Vijayakurup, Shabna Anwar, Sanu Thankachan, Kavya S Pillai, Jisha J Pillai, C Devika Nandan, Vijai V Alex, Teena Jacob Chirayil, Sankar Sundaram, Gopalakrishnapillai Sankaramangalam Vinod Kumar, Ruby John Anto
Nanoencapsulation has emerged as a novel strategy to enhance the pharmacokinetic and therapeutic potential of conventional drugs. Recent studies from our lab have established the efficacy of curcumin in sensitizing cervical cancer cells and breast cancer cells towards paclitaxel and 5-FU chemotherapy respectively. Factors that hinder the clinical use of curcumin as a sensitizer or therapeutic agent include its poor bioavailability and retention time. Earlier reports of improvement in bioavailability and retention of drugs upon nanoencapsulation have motivated us in developing various nanoformulations of curcumin, which were found to exhibit significant enhancement in bioavailability and retention time as assessed by our previous in vitro studies...
December 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/29283071/silk-fibroin-based-drug-delivery-applications-promises-and-challenges
#14
Shahid Ud Din Wani, Gangadharappa Hosahalli Veerabhadrappa
BACKGROUND: Silk Fibroin (SF), a natural source material obtained from Bombyx mori, has been widely enlisted as biomaterial having outstanding mechanical properties. SF has been reported one of the propitious bio-polymer for various drug delivery systems, as well as drug delivery vehicle. OBJECTIVE: This review is summarised to provide in comprehensive applications of silk fibroin in various drug delivery systems, and also to present the current opportunities and requirements by furnishing a definitive assessment on silk fibroin as a polymer...
December 27, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/29281876/concentration-dependent-effects-of-curcumin-on-5-fluorouracil-efficacy-in-bladder-cancer-cells
#15
Noushin Afsharmoghadam, Zahra Haghighatian, Hamid Mazdak, Nooshin Mirkheshti, Razieh Mehrabi Koushki, Sayyed Ali Alavi
Purpose: Curcumin (Cur), a herbal ingredient with anticancer properties, has been shown to inhibit growth of malignant cells in vivo and in vitro. However, studies on combination therapy of Cur with chemotherapeutic drugs have been limited. Here, effects of Cur on the cytotoxicity of 5-Fluorouracil (FU) were investigated with epithelial bladder cancer cells (EJ138) in vitro. Methods: EJ138 cells were treated with 5 and 15 μM of Cur and/ or 100 μM of FU. Cell viability was measured by sulforhodamine B colorimetric assay...
December 28, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29279114/enhancement-of-anticancer-activity-and-drug-delivery-of-chitosan-curcumin-nanoparticle-via-molecular-docking-and-simulation-analysis
#16
Priya Yadav, Arghya Bandyopadhyay, Anindita Chakraborty, Keka Sarkar
Computational analyses followed by traditional wet-bench experiments have become a method of choice due to successful results. To enhance the solubility and bioavailability of curcumin within chitosan nanoparticle, we have exploited computational methodologies i.e. docking, BBD-RSM and MD simulation for the polymer selection, NPs' formulation, optimization and their stability confirmation in an aqueous medium, respectively. Formulated CSCur NPs were assessed for in-vitro release, which exhibited a sustained release pattern and four-fold higher cytotoxic activity in a nanoparticulated system...
February 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29278208/identification-of-the-multifaceted-chemopreventive-activity-of-curcumin-against-the-carcinogenic-potential-of-the-food-additive-kbro3
#17
Ismael Obaidi, Michael Higgins, Bojlul Bahar, Jessica L Davis, Tara McMorrow
BACKGROUND: Potassium bromate (KBrO3), a food additive, has been used in many bakery products as an oxidizing agent. It has been shown to induce renal cancer in many in-vitro and in-vivo experimental models Objectives: This study evaluated the carcinogenic potential of potassium bromate (KBrO3) and the chemopreventive mechanisms of the anti-oxidant and anti-inflammatory phytochemical, curcumin against KBrO3-induced carcinogenicity Method: Lactate dehydrogenase (LDH) cytotoxicity assay and morphological characteristics were used to assess curcumin's cytoprotective potential against KBrO3 toxicity...
December 26, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29277765/traditional-chinese-medicine-curcumin-sensitizes-human-colon-cancer-to-radiation-by-altering-the-expression-of-dna-repair-related-genes
#18
Guangen Yang, Jianming Qiu, Dong Wang, Yong Tao, Yihuan Song, Hongtao Wang, Juping Tang, Xing Wang, Y U Sun, Zhijian Yang, Robert M Hoffman
BACKGROUND/AIM: The aim of the present study was to investigate the radio-sensitizing efficacy of curcumin, a traditional Chinese medicine (TCM) on colon cancer cells in vitro and in vivo. MATERIALS AND METHODS: Human colon cancer HT-29 cells were treated with curcumin (2.5 μM), irradiation (10 Gy) and the combination of irradiation and curcumin. Cell proliferation was assessed using the MTT assay. Apoptotic cells were detected by Annexin V-PE/7-AAD analysis. PCR was performed to determine differential-expression profiling of 95 DNA-repair genes in irradiated cells and cells treated with both irradiation and curcumin...
January 2018: Anticancer Research
https://www.readbyqxmd.com/read/29274436/bacillus-spore-based-oral-carriers-loading-curcumin-for-the-therapy-of-colon-cancer
#19
Liang Yin, Zhan Meng, Yuxiao Zhang, Kaikai Hu, Wuya Chen, Kaibin Han, Bao-Yan Wu, Rong You, Chu-Hua Li, Ying Jin, Yan-Qing Guan
Oral drug delivery has attracted substantial attention due to its advantages over other administration routes. Bacillus spores, as oral probiotic agents, are applied widely. In this paper, a novel Bacillus spore-based oral colon targeted carrier loading curcumin was developed for colon cancer treatment. Curcumin was linked covalently with the outer coat of Bacillus spore and folate, respectively (SPORE-CUR-FA). Bacillus spores are capable of delivering drugs to the colon area through gastric barrier, taking the advantage of its tolerance to the harsh conditions and disintegration of the outer coat of spores after germination in the colon...
December 20, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29273065/curcumin-synergizes-with-5-fluorouracil-by-impairing-ampk-ulk1-dependent-autophagy-akt-activity-and-enhancing-apoptosis-in-colon-cancer-cells-with-tumor-growth-inhibition-in-xenograft-mice
#20
Pan Zhang, Ze-Lin Lai, Hui-Fen Chen, Min Zhang, An Wang, Tao Jia, Wen-Qin Sun, Xi-Min Zhu, Xiao-Feng Chen, Zheng Zhao, Jun Zhang
BACKGROUND: Chemoresistance is a major obstacle that limits the benefits of 5-Fluorouracil (5-Fu)-based chemotherapy for colon cancer patients. Autophagy is an important cellular mechanism underlying chemoresistance. Recent research advances have given new insights into the use of natural bioactive compounds to overcome chemoresistance in colon cancer chemotherapy. As one of the multitargeted and safer phytomedicines, curcumin has been reported to work as cancer-specific chemosensitizer, presumably via induction of autophagic signaling pathways...
December 22, 2017: Journal of Experimental & Clinical Cancer Research: CR
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