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curcumin and cancer

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https://www.readbyqxmd.com/read/29147611/chloroquine-supplementation-increases-the-cytotoxic-effect-of-curcumin-against-her2-neu-overexpressing-breast-cancer-cells-in-vitro-and-in-vivo-in-nude-mice-while-counteracts-it-in-immune-competent-mice
#1
L Masuelli, M Granato, M Benvenuto, R Mattera, R Bernardini, M Mattei, G d'Amati, G D'Orazi, A Faggioni, R Bei, M Cirone
Autophagy is usually a pro-survival mechanism in cancer cells, especially in the course of chemotherapy, thus autophagy inhibition may enhance the chemotherapy-mediated anti-cancer effect. However, since autophagy is strongly involved in the immunogenicity of cell death by promoting ATP release, its inhibition may reduce the immune response against tumors, negatively influencing the overall outcome of chemotherapy. In this study, we evaluated the in vitro and in vivo anti-cancer effect of curcumin (CUR) against Her2/neu overexpressing breast cancer cells (TUBO) in the presence or in the absence of the autophagy inhibitor chloroquine (CQ)...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/29144788/panchakola-reduces-oxidative-stress-in-mcf-7-breast-cancer-and-hek293-cells
#2
Tooba Naz Shamsi, Romana Parveen, Sadaf Fatima
A large number of studies have proven the efficacy of ayurveda in the field of health and wellness. Panchakola, an ayurvedic formulation, is a general health tonic primarily used to cure fever, inflammation, pain, indigestion, and so on. We investigated effects of panchakola on oxidative stress in MCF-7 breast cancer and human embryonic kidney 293 (HEK293) cells. This work was performed to assess the antineoplastic and free radical-scavenging potential of aqueous extract of panchakola, a polyherbal formulation, in normal and breast cancer cell lines (i...
November 16, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29142607/curcumin-inhibits-mcf-7-cells-by-modulating-the-nf-%C3%AE%C2%BAb-signaling-pathway
#3
Jun-Li Liu, Yan-Yan Pan, Ou Chen, Yun Luan, Xia Xue, Jing-Jie Zhao, Ling Liu, Hong-Ying Jia
The present study investigated the inhibitory effect of curcumin on human breast cancer MCF-7 cells and investigated the potential underlying molecular mechanisms. MCF-7 cells were cultured with curcumin at different concentrations and time points. The effects of curcumin treatment on breast cancer cell proliferation were studied using a MTT assay. Reverse transcription-quantitative polymerase chain reaction and western blot analysis were used to assess the mRNA and protein expression levels of B-cell lymphoma 2 (Bcl-2) and Bcl-2-associated X (Bax), nuclear factor-κ-light-chain-enhancer of activated B cells (NF-κB) and inhibitor of NF-κB-α (IκBα)...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29141538/curcumin-a-natural-pan-hdac-inhibitor-in-cancer
#4
Sara Saffar Soflaei, Amir Abbas Momtazi, Muhammed Majeed, Giuseppe Derosa, Pamela Maffioli, Amirhossein Sahebkar
BACKGROUND: Histone deacetylases (HDACs) are a group of histone modification enzymes with pivotal role in disease pathogenesis especially in cancer development. Increased activity of certain types of HDACs and positive effects of HDAC inhibition has been shown in several types of cancers. Furthermore, few HDAC inhibitors have been approved by the FDA for cancer treatment, and this has generated interest in finding new HDAC inhibitors as potential anti-cancer agents. Curcumin, a natural polyphenol extracted from turmeric, is a safe and bioactive phytochemical with a wide range of molecular targets and pharmacological activities including promising anti-cancer properties...
November 14, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29139094/investigating-the-therapeutic-potential-and-mechanism-of-curcumin-in-breast-cancer-based-on-rna-sequencing-and-bioinformatics-analysis
#5
Rong Wang, Jinbin Li, Yulan Zhao, Yapeng Li, Ling Yin
BACKGROUND: Breast cancer is a prevalent cancer in female. This study aims to investigate the therapeutic potential and mechanism of curcumin in breast cancer. METHODS: After cultivation, human breast cancer cells (MCF-7 cells) were treated with 0.1% (v/v) 15 µmol/ml curcumin-dimethylsulfoxide solution and 0.1% (v/v) dimethylsulfoxide, respectively, at 37 °C and 5% CO2 for 48 h. Total RNA was extracted, cDNA library was constructed, and cDNAs were amplified and sequenced...
November 14, 2017: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/29138815/curcumin-reverses-tobacco-smoke%C3%A2-induced-epithelial%C3%A2-mesenchymal-transition-by-suppressing-the-mapk-pathway-in-the-lungs-of-mice
#6
Zhaofeng Liang, Rui Wu, Wei Xie, Mingming Zhu, Chunfeng Xie, Xiaoting Li, Jianyun Zhu, Weiwei Zhu, Jieshu Wu, Shanshan Geng, Wenrong Xu, Caiyun Zhong, Hongyu Han
Tobacco smoke is a major risk factor for lung cancer. Epithelial‑mesenchymal transition (EMT) is decisive in cancer invasion and metastasis, and therefore promotes cancer progression. Mitogen‑activated protein kinase (MAPK) pathways are implicated in various aspects of cancer development and progression, including the EMT process. The chemopreventive effect of curcumin on carcinogenesis has been reported in vivo and in vitro. The present study investigated tobacco smoke‑induced alterations in the MAPK/activator protein‑1 (AP‑1) pathways, and pulmonary EMT changes in the lungs of mice, and further observed the chemopreventive effect of curcumin...
November 13, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29138806/effect-of-bis-hydroxymethyl-alkanoate-curcuminoid-derivative-mth-3-on-cell-cycle-arrest-apoptotic-and-autophagic-pathway-in-triple-negative-breast-adenocarcinoma-mda-mb-231-cells-an-in-vitro-study
#7
Ling-Chu Chang, Min-Tsang Hsieh, Jai-Sing Yang, Chi-Cheng Lu, Fuu-Jen Tsai, Je-Wei Tsao, Yu-Jen Chiu, Sheng-Chu Kuo, Kuo-Hsiung Lee
Curcumin has been shown to exert potential antitumor activity in vitro and in vivo involved in multiple signaling pathways. However, the application of curcumin is still limited because of its poor hydrophilicity and low bio-availability. In the present study, we investigated the therapeutic effects of a novel and water soluble bis(hydroxymethyl) alkanoate curcuminoid derivative, MTH-3, on human breast adenocarcinoma MDA-MB-231 cells. This study investigated the effect of MTH-3 on cell viability, cell cycle and induction of autophagy and apoptosis in MDA-MB-231 cells...
November 14, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29128588/curcumin-loaded-chitin-glucan-quercetin-conjugate-synthesis-characterization-antioxidant-in-vitro-release-study-and-anticancer-activity
#8
Anu Singh, Lavkush, Amit Kumar Kureel, P K Dutta, Sushil Kumar, Ambak Kumar Rai
In this study, we have synthesized chitin-glucan quercetin conjugate (ChGCQ) by an easy and facile free radical grafting reaction. The structure of ChGCQ was confirmed by proton nuclear magnetic resonance ((1)H NMR) and Fourier transforms infrared spectroscopy (FT-IR). Curcumin was loaded into ChGCQ to study its anti-cancer efficiency. The biocompatibility of ChGCQ and curcumin loaded ChGCQ (Cu-ChGCQ) were analysed by different assays in Peripheral blood mononuclear cells (PBMCs) and cytotoxicity test was performed in a macrophage cancer cell line (J774)...
November 8, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29127008/direct-regulation-of-il-2-by-curcumin
#9
Jin-Gyo Oh, Da-Jeong Hwang, Tae-Hwe Heo
Interleukin-2 (IL-2) is a crucial growth factor for both regulatory and effector T cells. Thus, IL-2 plays a critical role in the stimulation and suppression of immune responses. Recently, anti-IL-2 antibodies (Abs) have been shown to possess strong IL-2 modulatory activities by affecting the interaction between IL-2 and IL-2 receptors. In this study, we screened an herbal library to identify a compound that regulates IL-2, which resulted in the identification of curcumin as a direct binder and inhibitor of IL-2...
November 7, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29126958/effects-of-led-based-photodynamic-therapy-using-red-and-blue-lights-with-natural-hydrophobic-photosensitizers-on-human-glioma-cell-line
#10
Zahra Jamali, Sedigheh Marjaneh Hejazi, Seyed Mohsen Ebrahimi, Hemen Moradi-Sardareh, Maliheh Paknejad
Photodynamic therapy (PDT) has received high attention in cancer treatment due to its minimal side effects, specific cancer-targeting, non-invasion and low cost. It utilizes a specific group of anti-cancer drugs called photosensitizers (PS), which can be only activated under a certain wavelength light illumination and kills cancer cells. To screen the potential of PS and setup of PDT treatment protocol, it is essential to assess the PDT efficacy in vitro. In this study, a light-emitting diode- (LED-) based illumination system at two wavelengths (red & blue) with homogeneous and stable irradiation, and constant temperature conditions in 96-well plates was provided...
November 7, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29118580/supercritical-carbon-dioxide-developed-silk-fibroin-nanoplatform-for-smart-colon-cancer-therapy
#11
Maobin Xie, Dejun Fan, Yi Li, Xiaowen He, Xiaoming Chen, Yufeng Chen, Jixiang Zhu, Guibin Xu, Xiaojian Wu, Ping Lan
Purpose: To deliver insoluble natural compounds into colon cancer cells in a controlled fashion. Materials and methods: Curcumin (CM)-silk fibroin (SF) nanoparticles (NPs) were prepared by solution-enhanced dispersion by supercritical CO2 (SEDS) (20 MPa pressure, 1:2 CM:SF ratio, 1% concentration), and their physicochemical properties, intracellular uptake efficiency, in vitro anticancer effect, toxicity, and mechanisms were evaluated and analyzed. Results: CM-SF NPs (<100 nm) with controllable particle size were prepared by SEDS...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29114108/therapeutic-effects-of-curcumin-on-ultrasonic-morphological-characteristics-of-liver-in-patients-with-metabolic-syndrome
#12
Senada Selmanovic, Azijada Beganlic, Nizama Salihefendic, Farid Ljuca, Albina Softic, Elvisa Smajic
Introduction: Metabolic syndrome (METS) represent a simultaneous presence of multiple metabolic disorders in one person. Prevalence is increasing worldwide, which is probably related to increased obesity and sedentary lifestyle. Non-alcoholic steatosis or "fatty liver" is a metabolic disease caused by fat dysfunction. It can be a sign of some other disease, and can often be found in patients with metabolic disorders. Ultrasound is an acceptable method for the identification of fatty steatosis...
September 2017: Acta Informatica Medica: AIM
https://www.readbyqxmd.com/read/29113871/oxidative-stress-and-dietary-phytochemicals-role-in-cancer-chemoprevention-and-treatment
#13
Shireen Chikara, Lokesh Dalasanur Nagaprashantha, Jyotsana Singhal, David Horne, Sanjay Awasthi, Sharad S Singhal
Several epidemiological observations have shown an inverse relation between consumption of plant-based foods, rich in phytochemicals, and incidence of cancer. Phytochemicals, secondary plant metabolites, via their antioxidant property play a key role in cancer chemoprevention by suppressing oxidative stress-induced DNA damage. In addition, they modulate several oxidative stress-mediated signaling pathways through their anti-oxidant effects, and ultimately protect cells from undergoing molecular changes that trigger carcinogenesis...
November 4, 2017: Cancer Letters
https://www.readbyqxmd.com/read/29112694/curcumin-dietary-supplements-and-everolimus-based-cancer-treatment
#14
O Mir, S Ropert, A N Chamseddine, A Paci
No abstract text is available yet for this article.
November 3, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29110292/development-of-chitosan-based-ph-sensitive-polymeric-micelles-containing-curcumin-for-colon-targeted-drug-delivery
#15
Thisirak Woraphatphadung, Warayuth Sajomsang, Theerasak Rojanarata, Tanasait Ngawhirunpat, Prasopchai Tonglairoum, Praneet Opanasopit
pH-sensitive N-naphthyl-N,O-succinyl chitosan (NSCS) and N-octyl-N,O-succinyl chitosan (OSCS) polymeric micelles carriers have been developed to incorporate curcumin (CUR) for colon-targeted drug delivery. The physical entrapment methods (dialysis, co-solvent evaporation, dropping, and O/W emulsion) were applied. The CUR-loaded micelles prepared by the dialysis method presented the highest loading capacity. Increasing initial amount of CUR from 5 to 40 wt% to polymer resulted in the increase in loading capacity of the polymeric micelles...
November 6, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29107813/curcumin-stably-interacts-with-dna-hairpin-through-minor-groove-binding-and-demonstrates-enhanced-cytotoxicity-in-combination-with-fdu-nucleotides
#16
Supratim Ghosh, Sumana Mallick, Upasana Das, Ajay Verma, Uttam Pal, Sabyasachi Chatterjee, Abhishek Nandy, Krishna D Saha, Nakul Chandra Maiti, Bikash Baishya, G Suresh Kumar, William H Gmeiner
We report, based on biophysical studies and molecular mechanical calculations that curcumin binds DNA hairpin in the minor groove adjacent to the loop region forming a stable complex. UV-Vis and fluorescence spectroscopy indicated interaction of curcumin with DNA hairpin. In this novel binding motif, two ɣ H of curcumin heptadiene chain are closely positioned to the A16-H8 and A17-H8, while G12-H8 is located in the close proximity of curcumin α H. Molecular dynamics (MD) simulations suggest, the complex is stabilized by noncovalent forces including; π-π stacking, H-bonding and hydrophobic interactions...
October 28, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29107110/nimbolide-reduces-cd44-positive-cell-population-and-induces-mitochondrial-apoptosis-in-pancreatic-cancer-cells
#17
Sandeep Kumar, Joseph R Inigo, Rahul Kumar, Ajay K Chaudhary, Jordan O'Malley, Srimmitha Balachandar, Jianmin Wang, Kristopher Attwood, Neelu Yadav, Steven Hochwald, Xinjiang Wang, Dhyan Chandra
Pancreatic ductal adenocarcinoma (PDAC) is highly aggressive disease and current treatment regimens fail to effectively cure PDAC. Development of resistance to current therapy is one of the key reasons for this outcome. Nimbolide (NL), a triterpenoid obtained from Azadirachta indica, exhibits anticancer properties in various cancer including PDAC cells. However, the underlying mechanism of this anticancer agent in PDAC cells remains undefined. We show that NL exerts a higher level of apoptotic cell death compared to the first-line agent gemcitabine for PDAC, as well as other anticancer agents including sorafenib and curcumin...
October 26, 2017: Cancer Letters
https://www.readbyqxmd.com/read/29103764/additive-cytotoxic-effects-of-radiation-and-mtor-inhibitors-in-a-cervical-cancer-cell-line
#18
Daniele Xavier Assad, Gabriel Alvares Borges, Samuel Ramalho Avelino, Eliete Neves Silva Guerra
The PI3K/AKT/mTOR signaling pathway is frequently activated in HPV-positive cervical squamous cell cancer (CC). This study investigated the biological effects of mTOR inhibitors associated with radiotherapy in a CC cell line (HeLa). A human keratinocyte cell line (HaCaT) was used as control. Temsirolimus, everolimus, resveratrol, curcumin and epigallocatechin gallate (EGCG) were the mTOR inhibitors assessed. The 50% cell cytotoxicity rate (CC50) for each treatment was determined by MTT cell viability assay...
November 2, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29094265/synthesis-and-cytotoxic-activity-of-novel-tetrahydrocurcumin-derivatives-bearing-pyrazole-moiety
#19
Ahmed Mahal, Ping Wu, Zi-Hua Jiang, Xiaoyi Wei
Tetrahydrocurcumin (THC) is a major metabolite of curcumin and plays an important role in curcumin-induced biological effects. THC is a promising preventive and chemotherapeutic agent for cancer. A series of new pyrazole derivatives of THC have been synthesized as potent anticancer agents. Direct condensation of THC with various substituted hydrazines leads to new pyrazole derivatives of THC (1-18). The prepared compounds have been evaluated via in vitro MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay for their cell proliferation-inhibitory activity against human lung adenocarcinoma (A549), human cervical carcinoma (HeLa) and human breast carcinoma (MCF-7) cells...
November 1, 2017: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/29089332/chemopreventive-and-antitumor-efficacy-of-curcumin-in-a-spontaneously-developing-hen-ovarian-cancer-model
#20
Kazim Sahin, Cemal Orhan, Mehmet Tuzcu, Nurhan Sahin, Hakki Tastan, Ibrahim Hanifi Ozercan, Osman Guler, Nermin Kahraman, Omer Kucuk, Bulent Ozpolat
We investigated the effect of daily dietary curcumin intake on the development and progression of spontaneous ovarian cancer in a galline (hen) model, as the chicken is the only nonhuman animal in which ovarian cancer spontaneously develops with a high prevalence. At the end of 12 months, ovarian cancer had spontaneously developed in 39% (35/90) of control hens not fed curcumin (n = 90). In comparison, it spontaneously developed in 27% (24/90) and 17% (15/90) of hens given curcumin at 25.8 (n=90) and 53.0 mg/day (n=90), respectively (P = 0...
October 31, 2017: Cancer Prevention Research
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