Andrew Chancellor, Robert Alan Simmons, Rahul C Khanolkar, Vladimir Nosi, Aisha Beshirova, Giuliano Berloffa, Rodrigo Colombo, Vijaykumar Karuppiah, Johanne M Pentier, Vanessa Tubb, Hemza Ghadbane, Richard J Suckling, Keith Page, Rory M Crean, Alessandro Vacchini, Corinne De Gregorio, Verena Schaefer, Daniel Constantin, Thomas Gligoris, Angharad Lloyd, Miriam Hock, Velupillai Srikannathasan, Ross A Robinson, Gurdyal S Besra, Marc W van der Kamp, Lucia Mori, Raffaele Calogero, David K Cole, Gennaro De Libero, Marco Lepore
Mucosal-associated invariant T (MAIT) cells use canonical semi-invariant T cell receptors (TCR) to recognize microbial riboflavin precursors displayed by the antigen-presenting molecule MR1. The extent of MAIT TCR crossreactivity toward physiological, microbially unrelated antigens remains underexplored. We describe MAIT TCRs endowed with MR1-dependent reactivity to tumor and healthy cells in the absence of microbial metabolites. MAIT cells bearing TCRs crossreactive toward self are rare but commonly found within healthy donors and display T-helper-like functions in vitro...
September 4, 2023: Journal of Experimental Medicine