Dmitry P Krut'ko, Alexey V Medved'ko, Konstantin A Lyssenko, Andrei V Churakov, Alexander I Dalinger, Mikhail A Kalinin, Alexey O Gudovannyy, Konstantin Y Ponomarev, Eugeny V Suslov, Sergey Z Vatsadze
In this work, the solution conformations of seventeen 3,7-diacyl bispidines were studied by means of NMR spectroscopy including VT NMR experiments. The acyl groups included alkyl, alkenyl, aryl, hetaryl, and ferrocene moieties. The presence of syn/anti-isomers and their ratios were estimated, and some reasons explaining experimental facts were formulated. In particular, all aliphatic and heterocyclic units in the acylic R(CO) fragments led to an increased content of the syn -form in DMSO- d 6 solutions. In contrast, only the anti -form was detected in DMSO- d 6 and CDCl3 in the case when R = Ph, ferrocenyl, ( R )-myrtenyl...
January 10, 2022: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry