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https://www.readbyqxmd.com/read/28917274/the-interventional-oncologist-the-fourth-musketeer-of-cancer-care
#1
EDITORIAL
F H Cornelis
No abstract text is available yet for this article.
September 2017: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/28917252/stereotactic-radiosurgery-of-the-brain-a-review-of-common-indications
#2
Philip Gilbo, Isabella Zhang, Jonathan Knisely
Over the past half-century since Lars Leksell first utilized radiation to address deep and difficult to treat lesions of the central nervous system (CNS), intracranial stereotactic radiosurgery (SRS) has become an increasingly valued tool in the hands of neurosurgeons and radiation oncologists. Following developments in medical imaging and radiation technology, radiosurgery has evolved from its first application in movement disorders to widespread use for a varied range of malignant and benign conditions. SRS remains a powerful, minimally invasive instrument that offers additional options for intervention to a diverse patient population...
September 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28917141/the-impact-of-black-cancer-patients-race-related-beliefs-and-attitudes-on-racially-discordant-oncology-interactions-a-field-study
#3
Louis A Penner, Felicity W K Harper, John F Dovidio, Terrance L Albrecht, Lauren M Hamel, Nicole Senft, Susan Eggly
OBJECTIVE: Both physician and patient race-related beliefs and attitudes are contributors to racial healthcare disparities, but only the former have received substantial research attention. Using data from a study conducted in the Midwestern US from 2012 to 2014, we investigated whether 114 Black cancer patients' existing race-related beliefs and attitudes would predict how they and 18 non-Black physicians (medical oncologists) would respond in subsequent clinical interactions. METHOD: At least two days before interacting with an oncologist for initial discussions of treatment options, patients completed measures of perceived past discrimination, general mistrust of physicians, and suspicion of healthcare systems; interactions were video-recorded...
August 30, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28916198/treatment-outcome-and-quality-of-life-of-1239-patients-with-advanced-non-small-cell-lung-cancer-final-results-from-the-prospective-german-tlk-cohort-study
#4
Ulla von Verschuer, Roland Schnell, Hans Werner Tessen, Jochen Eggert, Adrian Binninger, Lisa Spring, Martina Jänicke, Norbert Marschner
OBJECTIVES: Real-life data on advanced non-small cell lung cancer (NSCLC) are centrally important to complement the results from clinical trials and to improve the standard of care. We present data on the choice of systemic first- and second-line treatment, number of treatment lines, survival and longitudinal data on health-related quality of life (HRQOL) of patients treated by medical oncologists in Germany. MATERIALS AND METHODS: 1239 patients with advanced NSCLC were recruited at start of first-line therapy into the prospective German clinical cohort study TLK (Tumour Registry Lung Cancer) by 107 sites between February 2010 and December 2013 and followed-up until January 2016...
August 22, 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28915086/effective-physical-activity-promotion-to-survivors-of-cancer-is-likely-to-be-home-based-and-to-require-oncologist-participation
#5
Sarah J Hardcastle, Paul A Cohen
No abstract text is available yet for this article.
September 15, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28915075/responding-to-patient-requests-for-hastened-death-physician-aid-in-dying-and-the-clinical-oncologist
#6
Rebecca A Spence, Charles D Blanke, Thomas J Keating, Lynne P Taylor
Physician aid in dying (PAD) or assisted suicide is becoming legal in more US jurisdictions. Meanwhile, the needs of terminally ill patients with cancer are receiving greater attention, including the integration of palliative care into oncology practice. This article highlights a case vignette of a patient with advanced cancer who requests PAD from her oncologist, as a backdrop to help the practicing oncologist examine his or her moral stance regarding participation in aid in dying. The article concludes by offering a framework within which the practicing oncologist can receive and process a patient's request for PAD...
September 15, 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/28914366/geriatric-assessment-with-management-intervention-in-older-adults-with-cancer-a-randomized-pilot-study
#7
Allison Magnuson, Tatyana Lemelman, Chintan Pandya, Molly Goodman, Marcus Noel, Mohammed Tejani, David Doughtery, William Dale, Arti Hurria, Michelle Janelsins, Feng Vankee Lin, Charles Heckler, Supriya Mohile
BACKGROUND: Older adults receiving cancer therapy have heightened risk for treatment-related toxicity. Geriatric assessment (GA) can identify impairments, which may contribute to vulnerability and adverse outcomes. GA management interventions can address these impairments and have the potential to improve outcomes when implemented. METHODS: We conducted a randomized pilot study comparing GA with management interventions versus usual care in patients with stage III/IV solid tumor malignancies (N = 71)...
September 15, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28911084/the-critical-mass-survey-of-palliative-care-programme-at-esmo-designated-centres-of-integrated-oncology-and-palliative-care
#8
D Hui, N Cherny, N Latino, F Strasser
Background: The ESMO Designated Centres (ESMO-DCs) of Integrated Oncology and Palliative Care (PC) Incentive Programme has grown steadily. We aimed to characterise the level of PC clinical services, education and research at ESMO-DCs. Methods: We sent all 184 ESMO-DCs an electronic survey consisting of 78 questions examining the DC characteristics, palliative care clinical programme (structure, processes, and outcomes), primary PC delivery by oncologists, education, research and attitudes and beliefs towards the ESMO-DC programme...
September 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28911072/oncologist-use-and-perception-of-large-panel-next-generation-tumor-sequencing
#9
A M Schram, D Reales, J Galle, R Cambria, R Durany, D Feldman, E Sherman, J Rosenberg, G D'Andrea, S Baxi, Y Janjigian, W Tap, M Dickler, J Baselga, B S Taylor, D Chakravarty, J Gao, N Schultz, D B Solit, M F Berger, D M Hyman
Background: Genomic profiling is increasingly incorporated into oncology research and the clinical care of cancer patients. We sought to determine physician perception and use of enterprise-scale clinical sequencing at our center, including whether testing changed management and the reasoning behind this decision-making. Patients and methods: All physicians who consented patients to MSK-IMPACT, a next-generation hybridization capture assay, in tumor types where molecular profiling is not routinely performed were asked to complete a questionnaire for each patient...
September 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28911059/forcing-the-vicious-circle-sarcopenia-increases-toxicity-decreases-response-to-chemotherapy-and-worsens-with-chemotherapy
#10
F Bozzetti
Sarcopenia has recently emerged as a new condition that, independently from malnutrition, may adversely affect the prognosis of cancer patients. Purpose of this narrative review is to define the prevalence of sarcopenia in different primaries, its role in leading to chemotherapy toxicity and decreased compliance with the oncological therapy and the effect of some drugs on the onset of sarcopenia. Finally, the review aims to describe the current approaches to restore the muscle mass through nutrition, exercise and anti-inflammatory agents or multimodal programmes with a special emphasis on the results of randomized controlled trials...
September 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28902795/magnetic-resonance-imaging-of-neuroendocrine-tumor-hepatic-metastases-does-hepatobiliary-phase-imaging-improve-lesion-conspicuity-and-interobserver-agreement-of-lesion-measurements
#11
Brian Morse, Daniel Jeong, Kerry Thomas, Dalanda Diallo, Jonathan R Strosberg
OBJECTIVE: The aim of this study was to determine if magnetic resonance imaging (MRI) performed with hepatobiliary phase imaging results in higher lesion conspicuity and produces lesion measurements with higher interobserver agreement than other MRI sequences when imaging neuroendocrine hepatic metastases. METHODS: Patients who had MRIs with both gadoxetate disodium and gadopentetate dimeglumine contrast within a 6-month span were identified, and 23 hepatic lesions were selected...
October 2017: Pancreas
https://www.readbyqxmd.com/read/28902376/-priorities-of-german-oncologists-results-of-the-choosing-wisely-survey-of-the-german-society-of-hematology-and-medical-oncology-dgho
#12
Stefan W Krause, Michael Oldenburg, Michael Hallek, Andreas Neubauer
Background During the preparation of "choosing wisely" recommendations, the German Society of Hematology and Medical Oncology (DGHO) had performed a member survey. The large body of replies was systematically and quantitatively analyzed for this report. Methods Replies to the draft recommendations are quantified. Free text replies were iteratively categorized in three levels according to medical categories and additionally, according to their general target of necessary action. Results 492 members completed the survey within the given limit of 2 weeks...
September 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28900321/pattern-of-adverse-drug-reactions-to-anticancer-drugs-a-quantitative-and-qualitative-analysis
#13
Shruti Singh, D C Dhasmana, Manisha Bisht, Prashant Kumar Singh
INTRODUCTION: Anticancer drugs contribute significantly to the global burden of adverse drug reactions (ADRs). Any attempt to quantify their magnitude and provide upgraded knowledge would help oncologists in writing safer prescriptions. AIM: This observational follow-up study was conducted on newly diagnosed cancer patients receiving anticancer therapy with an aim to determine the frequency, severity, causality, predictability, and preventability of ADRs. SUBJECTS AND METHODS: The patients were followed up for 6 months for the appearance of adverse events...
April 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/28898605/the-team-approach-to-improving-oncology-outcomes-by-incorporating-palliative-care-in-practice
#14
Marie A Bakitas, Areej El-Jawahri, Morag Farquhar, Betty Ferrell, Corita Grudzen, Irene Higginson, Jennifer S Temel, Camilla Zimmermann, Thomas J Smith
Palliative care (PC) concurrent with usual oncology care is now the standard of care that is recommended for any patient with advanced cancer to begin within 8 weeks of diagnosis on the basis of evidence-driven national clinical practice guidelines; however, there are not enough interdisciplinary palliative care teams to provide such care. How and what can an oncology office incorporate into usual care, borrowing the tools used in PC randomized clinical trials (RCTs), to improve care for patients and their caregivers? We reviewed the multiple RCTs for common practical elements and identified methods and techniques that oncologists can use to deliver some parts of concurrent interdisciplinary PC...
September 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/28895233/validation-of-the-opportunity-for-treatment-in-oncology-option-questionnaire-measuring-continuity-of-care
#15
Paola Rucci, Silvia Foglino, Francesca Bravi, Rossella D'Avenia, Mattia Altini, Tiziano Carradori, Angela Angelastro, Maria Pia Fantini
Increasing efforts are ongoing to deliver effective cancer care through integrated networks of services. Measuring patients' experience of care is essential to identify problematic areas that require organisational adjustments. The aim of the present study was to examine the validity of OPTION questionnaire, designed to measure patient's perceived continuity of care across different phases of their care pathway. The study was carried at the Institute for Cancer Treatment and Research, Meldola and the oncology departments of the Local Health Authority of Romagna, Italy...
September 11, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28893255/oncologist-burnout-and-compassion-fatigue-investigating-time-pressure-at-work-as-a-predictor-and-the-mediating-role-of-work-family-conflict
#16
Sibyl Kleiner, Jean E Wallace
BACKGROUND: Oncologists are at high risk of poor mental health. Prior research has focused on burnout, and has identified heavy workload as a key predictor. Compassion fatigue among physicians has generally received less attention, although medical specialties such as oncology may be especially at risk of compassion fatigue. We contribute to research by identifying predictors of both burnout and compassion fatigue among oncologists. In doing so, we distinguish between quantitative workload (e...
September 11, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28892215/living-with-life-prolonging-chemotherapy-control-and-meaning-making-in-the-tension-between-life-and-death
#17
K Kvåle, O Synnes
Chemotherapy, radiotherapy, hormone therapy and immune therapy have made many cancers chronic, potential curable diseases rather than inevitably fatal, but the treatments are often both mentally and physically stressful even if the side effects varies. The right use of palliative chemotherapy is a complex issue and there are many aspects to take into consideration. The aim of the study was to gain insight into the illness narratives of cancer patients, from the day they suspected that something was wrong up to the present day where they are living with incurable cancer, undergoing life-prolonging chemotherapy...
September 11, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28892208/perspectives-of-oncology-nurses-and-oncologists-regarding-barriers-to-working-with-patients-from-a-minority-background-systemic-issues-and-working-with-interpreters
#18
K J Watts, B Meiser, E Zilliacus, R Kaur, M Taouk, A Girgis, P Butow, D W Kissane, S Hale, A Perry, S K Aranda, D Goldstein
This study aimed to ascertain the systemic barriers encountered by oncology health professionals (HPs) working with patients from ethnic minorities to guide the development of a communication skills training programme. Twelve medical and five radiation oncologists and 21 oncology nurses were invited to participate in this qualitative study. Participants were interviewed individually or in a focus group about their experiences working with people from minority backgrounds. All interviews were transcribed verbatim and analysed thematically...
September 11, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28891217/reproducibility-of-f18-fdg-pet-radiomic-features-for-different-cervical-tumor-segmentation-methods-gray-level-discretization-and-reconstruction-algorithms
#19
Baderaldeen A Altazi, Geoffrey G Zhang, Daniel C Fernandez, Michael E Montejo, Dylan Hunt, Joan Werner, Matthew C Biagioli, Eduardo G Moros
Site-specific investigations of the role of radiomics in cancer diagnosis and therapy are emerging. We evaluated the reproducibility of radiomic features extracted from (18) Flourine-fluorodeoxyglucose ((18) F-FDG) PET images for three parameters: manual versus computer-aided segmentation methods, gray-level discretization, and PET image reconstruction algorithms. Our cohort consisted of pretreatment PET/CT scans from 88 cervical cancer patients. Two board-certified radiation oncologists manually segmented the metabolic tumor volume (MTV1 and MTV2 ) for each patient...
September 11, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28890946/oncokb-a-precision-oncology-knowledge-base
#20
Debyani Chakravarty, Jianjiong Gao, Sarah M Phillips, Ritika Kundra, Hongxin Zhang, Jiaojiao Wang, Julia E Rudolph, Rona Yaeger, Tara Soumerai, Moriah H Nissan, Matthew T Chang, Sarat Chandarlapaty, Tiffany A Traina, Paul K Paik, Alan L Ho, Feras M Hantash, Andrew Grupe, Shrujal S Baxi, Margaret K Callahan, Alexandra Snyder, Ping Chi, Daniel Danila, Mrinal Gounder, James J Harding, Matthew D Hellmann, Gopa Iyer, Yelena Janjigian, Thomas Kaley, Douglas A Levine, Maeve Lowery, Antonio Omuro, Michael A Postow, Dana Rathkopf, Alexander N Shoushtari, Neerav Shukla, Martin Voss, Ederlinda Paraiso, Ahmet Zehir, Michael F Berger, Barry S Taylor, Leonard B Saltz, Gregory J Riely, Marc Ladanyi, David M Hyman, José Baselga, Paul Sabbatini, David B Solit, Nikolaus Schultz
PURPOSE: With prospective clinical sequencing of tumors emerging as a mainstay in cancer care, there is an urgent need for a clinical support tool that distills the clinical implications associated with specific mutation events into a standardized and easily interpretable format. To this end, we developed OncoKB, an expert-guided precision oncology knowledge base. METHODS: OncoKB annotates the biological and oncogenic effect and the prognostic and predictive significance of somatic molecular alterations...
July 2017: JCO Precis Oncol
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