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Richard Packard

Zoel A Quinonez, Laura Downey, Rania K Abbasi, Calvin Kuan, Ritu Asija, Doff B McElhinney, Frank L Hanley, Richard D Mainwaring, Lisa Wise-Faberowski
Tetralogy of Fallot with pulmonary atresia and major aortopulmonary collaterals (TOF/PA/MAPCAs) is a heterogeneous disease with varying degrees of severity, requiring complex anesthetic management. Our institution has adopted the approach of early complete repair with incorporation of all lung segments, extensive lobar and branch segmental pulmonary artery reconstruction, and ventricular septal defect closure. While the surgical management of TOF/PA/MAPCAs has been extensively described and varies depending on the institution, there is a paucity of literature on the anesthetic management for such procedures...
March 2018: World Journal for Pediatric & Congenital Heart Surgery
Rathan M Subramaniam, Hossein Jadvar, Patrick M Colletti, Alexander Guimaraes, Rao Gullapali, Andrei H Iagaru, Jonathan McConathy, Carolyn C Meltzer, Helen Nadel, Richard B Noto, Alan B Packard, Eric Rohren, M Elizabeth Oates
This joint statement is intended to guide credentialing bodies that privilege physicians to oversee the performance of and participation in the interpretation of PET/MR imaging in adult and pediatric patients in the United States.
May 4, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Brian J Bennett, Richard C Davis, Mete Civelek, Luz Orozco, Judy Wu, Hannah Qi, Calvin Pan, René R Sevag Packard, Eleazar Eskin, Mujing Yan, Todd Kirchgessner, Zeneng Wang, Xinmin Li, Jill C Gregory, Stanley L Hazen, Peter S Gargalovic, Aldons J Lusis
No abstract text is available yet for this article.
March 2016: PLoS Genetics
Hossein Jadvar, Rathan M Subramaniam, Claudia G Berman, Fernando Boada, Patrick M Colletti, Alexander R Guimaraes, Jonathan McConathy, Carolyn C Meltzer, Richard B Noto, Alan B Packard, Eric M Rohren, M Elizabeth Oates
No abstract text is available yet for this article.
April 2015: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Sergio A Carrillo, Richard D Mainwaring, Justin M Schaffer, Gail Wright, Katsuhide Maeda, Frank L Hanley, V Mohan Reddy
OBJECTIVE: It is recognized that there are numerous anatomic variants that result in hypoplastic left heart physiology. One such variant includes critical aortic stenosis or atresia, a hypoplastic aortic arch, and a reasonably well-developed left ventricle due to the presence of a ventricular septal defect. These patients are candidates for 1 of 3 surgical options: (1) a Norwood procedure followed by a single-ventricle pathway; (2) a Norwood procedure followed by a Rastelli procedure (2-stage Yasui); or (3) a single-stage Yasui procedure...
February 2015: Journal of Thoracic and Cardiovascular Surgery
Lakshmanan Krishnamurti, Bethanny Smith-Packard, Ashish Gupta, Mary Campbell, Sriya Gunawardena, Richard Saladino
BACKGROUND: Vaso-occlusive crisis (VOC) the hallmark of sickle cell disease (SCD) is often treated inadequately in the emergency department (ED). We hypothesized that pain management plans individualized for each patient can improve pain management and lead to high levels of patient satisfaction. PROCEDURE: Starting in 2002, we treated all patients with SCD reporting to Children's Hospital of Pittsburgh (CHP) ED with VOC using a structured algorithm. We recorded regimens used successfully for each patient as an "individualized pain plan" and implemented it during subsequent VOC visits and adjusted it to patient response...
October 2014: Pediatric Blood & Cancer
Richard C Krolewski, Adam Packard, Woochan Jang, Hendrik Wildner, James E Schwob
The embryonic olfactory epithelium (OE) generates only a very few olfactory sensory neurons when the basic helix-loop-helix transcription factor, ASCL1 (previously known as MASH1) is eliminated by gene mutation. We have closely examined the structure and composition of the OE of knockout mice and found that the absence of neurons dramatically affects the differentiation of multiple other epithelial cell types as well. The most prominent effect is observed within the two known populations of stem and progenitor cells of the epithelium...
2012: PloS One
Sally Schwarz, Jeffrey Norenberg, Marc Berridge, Stephen Dragotakes, Joseph Hung, Jeanne Link, N Scott Mason, Steve Mattmuller, Richard A Nickel, Alan Packard, Justin Paolino, Neil Petry, James Ponto, Timothy M Quinton, Katherine L Seifert, Dennis Swanson, Ronald E Weiner, Steven Zigler
No abstract text is available yet for this article.
March 2013: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Stephen Kaptoge, Emanuele Di Angelantonio, Lisa Pennells, Angela M Wood, Ian R White, Pei Gao, Matthew Walker, Alexander Thompson, Nadeem Sarwar, Muriel Caslake, Adam S Butterworth, Philippe Amouyel, Gerd Assmann, Stephan J L Bakker, Elizabeth L M Barr, Elizabeth Barrett-Connor, Emelia J Benjamin, Cecilia Björkelund, Hermann Brenner, Eric Brunner, Robert Clarke, Jackie A Cooper, Peter Cremer, Mary Cushman, Gilles R Dagenais, Ralph B D'Agostino, Rachel Dankner, George Davey-Smith, Dorly Deeg, Jacqueline M Dekker, Gunnar Engström, Aaron R Folsom, F Gerry R Fowkes, John Gallacher, J Michael Gaziano, Simona Giampaoli, Richard F Gillum, Albert Hofman, Barbara V Howard, Erik Ingelsson, Hiroyasu Iso, Torben Jørgensen, Stefan Kiechl, Akihiko Kitamura, Yutaka Kiyohara, Wolfgang Koenig, Daan Kromhout, Lewis H Kuller, Debbie A Lawlor, Tom W Meade, Aulikki Nissinen, Børge G Nordestgaard, Altan Onat, Demosthenes B Panagiotakos, Bruce M Psaty, Beatriz Rodriguez, Annika Rosengren, Veikko Salomaa, Jussi Kauhanen, Jukka T Salonen, Jonathan A Shaffer, Steven Shea, Ian Ford, Coen D A Stehouwer, Timo E Strandberg, Robert W Tipping, Alberto Tosetto, Sylvia Wassertheil-Smoller, Patrik Wennberg, Rudi G Westendorp, Peter H Whincup, Lars Wilhelmsen, Mark Woodward, Gordon D O Lowe, Nicholas J Wareham, Kay-Tee Khaw, Naveed Sattar, Chris J Packard, Vilmundur Gudnason, Paul M Ridker, Mark B Pepys, Simon G Thompson, John Danesh
BACKGROUND: There is debate about the value of assessing levels of C-reactive protein (CRP) and other biomarkers of inflammation for the prediction of first cardiovascular events. METHODS: We analyzed data from 52 prospective studies that included 246,669 participants without a history of cardiovascular disease to investigate the value of adding CRP or fibrinogen levels to conventional risk factors for the prediction of cardiovascular risk. We calculated measures of discrimination and reclassification during follow-up and modeled the clinical implications of initiation of statin therapy after the assessment of CRP or fibrinogen...
October 4, 2012: New England Journal of Medicine
Jennifer Rydzewski, Nohra Mateus-Pinilla, Richard E Warner, Jeffrey A Nelson, Tom C Velat
Considering recent studies confirming an increased risk of contracting Lyme disease near metropolitan Chicago, we surveyed a more comprehensive area to assess whether the geographical distribution and establishment of Ixodes scapularis (Say) populations across northeast Illinois are widespread or limited in occurrence. From May through October 2008 and from April through October 2009, 602 I. scapularis ticks of all three life stages (larva, nymph, adult) were collected from sites in Cook, DuPage, Lake, and McHenry counties in northeast Illinois...
July 2012: Journal of Medical Entomology
Richard C Krolewski, Adam Packard, James E Schwob
Ongoing, lifelong neurogenesis maintains the neuronal population of the olfactory epithelium in the face of piecemeal neuronal turnover and restores it following wholesale loss. The molecular phenotypes corresponding to different stages along the progression from multipotent globose basal cell (GBC) progenitor to differentiated olfactory sensory neuron are poorly characterized. We used the transgenic expression of enhanced green fluorescent protein (eGFP) and cell surface markers to FACS-isolate ΔSox2-eGFP(+) GBCs, Neurog1-eGFP(+) GBCs and immature neurons, and ΔOMP-eGFP(+) mature neurons from normal adult mice...
March 1, 2013: Journal of Comparative Neurology
Emanuele Di Angelantonio, Pei Gao, Lisa Pennells, Stephen Kaptoge, Muriel Caslake, Alexander Thompson, Adam S Butterworth, Nadeem Sarwar, David Wormser, Danish Saleheen, Christie M Ballantyne, Bruce M Psaty, Johan Sundström, Paul M Ridker, Dorothea Nagel, Richard F Gillum, Ian Ford, Pierre Ducimetiere, Stefan Kiechl, Wolfgang Koenig, Robin P F Dullaart, Gerd Assmann, Ralph B D'Agostino, Gilles R Dagenais, Jackie A Cooper, Daan Kromhout, Altan Onat, Robert W Tipping, Agustín Gómez-de-la-Cámara, Annika Rosengren, Susan E Sutherland, John Gallacher, F Gerry R Fowkes, Edoardo Casiglia, Albert Hofman, Veikko Salomaa, Elizabeth Barrett-Connor, Robert Clarke, Eric Brunner, J Wouter Jukema, Leon A Simons, Manjinder Sandhu, Nicholas J Wareham, Kay-Tee Khaw, Jussi Kauhanen, Jukka T Salonen, William J Howard, Børge G Nordestgaard, Angela M Wood, Simon G Thompson, S Matthijs Boekholdt, Naveed Sattar, Chris Packard, Vilmundur Gudnason, John Danesh
CONTEXT: The value of assessing various emerging lipid-related markers for prediction of first cardiovascular events is debated. OBJECTIVE: To determine whether adding information on apolipoprotein B and apolipoprotein A-I, lipoprotein(a), or lipoprotein-associated phospholipase A2 to total cholesterol and high-density lipoprotein cholesterol (HDL-C) improves cardiovascular disease (CVD) risk prediction. DESIGN, SETTING, AND PARTICIPANTS: Individual records were available for 165,544 participants without baseline CVD in 37 prospective cohorts (calendar years of recruitment: 1968-2007) with up to 15,126 incident fatal or nonfatal CVD outcomes (10,132 CHD and 4994 stroke outcomes) during a median follow-up of 10...
June 20, 2012: JAMA: the Journal of the American Medical Association
Richard N Pitt, Josh Packard
Racial diversity is understood to play an important role for all students on the college campus. In recent years, much effort has gone into documenting the positive effects of this diversity. However, few studies have focused on how diversity impacts student interactions in the classroom, and even fewer studies attempt to quantify contributions from students of different races. Using Web blog discussions about race and religion, the authors uncover the differences in contributions black and white students make to those discussions...
2012: Sociological Quarterly
Sarah F Poissant, Richard L Freyman, Allison J MacDonald, Heather A Nunes
OBJECTIVES: The objectives of this investigation were to quantify noise exposures generated during a 1 hr trumpet practice session and to determine whether distortion-product otoacoustic emissions (DPOAEs) are affected by such exposure, to describe the distribution of intensity levels and temporal characteristics of noise produced by trumpet practice, and to determine the effect of earplug use on generated noise levels and DPOAEs. DESIGN: In experiment 1, eight college-age trumpeters underwent an otoscopic inspection, tympanometry, and pure-tone threshold testing...
July 2012: Ear and Hearing
Gokulan Ratnarajan, Richard Packard, Mina Ward
PURPOSE: To study the impact of a new power-delivery option using occlusion-triggered bursts of longitudinal phaco energy in addition to torsional tip movement in the performance of the 30-degree mini-flared tip to minimize tip clogging with dense nuclei. SETTING: Prince Charles Eye Unit, King Edward VII Hospital, Windsor, United Kingdom. DESIGN: Comparative case series. METHOD: The cumulative dissipated energy (CDE) and time in foot pedal position 3 (FP3) to phacoemulsify each half of the nucleus with and without use of the new power-delivery option (Intelligent Phaco) were compared...
May 2011: Journal of Cataract and Refractive Surgery
Daniel Calladine, Mina Ward, Richard Packard
PURPOSE: To assess an adherent ocular bandage for clear corneal incisions (CCIs) in cataract surgery using optical coherence tomography (OCT). SETTING: Prince Charles Eye Unit, Windsor, United Kingdom. DESIGN: Case-control study. METHODS: Patients having coaxial microincision cataract surgery (MICS) were allocated to an adherent ocular bandage group or to a control group. The CCIs were examined postoperatively within 2 hours and at 24 hours and 7 days using OCT imaging and a slitlamp fluorescein 2% Seidel test...
November 2010: Journal of Cataract and Refractive Surgery
Zhen Guo, Adam Packard, Richard C Krolewski, Margaret T Harris, Glen L Manglapus, James E Schwob
The olfactory epithelium maintains stem and progenitor cells that support the neuroepithelium's life-long capacity to reconstitute after injury. However, the identity of the stem cells--and their regulation--remain poorly defined. The transcription factors Pax6 and Sox2 are characteristic of stem cells in many tissues, including the brain. Therefore, we assessed the expression of Pax6 and Sox2 in normal olfactory epithelium and during epithelial regeneration after methyl bromide lesion or olfactory bulbectomy...
November 1, 2010: Journal of Comparative Neurology
Joanne R Lupton, Douglas A Balentine, Richard M Black, Regina Hildwine, Barbara J Ivens, Eileen T Kennedy, Patricia T Packard, Bradley R Sperber, Daniel Steffen, Mary Story
The goal of the Smart Choices Program (SCP) is to provide a simple front-of-the-package icon system to direct consumers to smarter food choices in the supermarket, which will eventually lead to more balanced diets and to more beneficial foods as food manufacturers renovate products to meet the nutrition criteria for carrying the icon. The SCP was developed by a coalition of scientists and nutrition educators, experts with experience with dietary guidelines, public health organizations, and food manufacturers in response to consumer confusion over multiple front-of-the-package systems based on different criteria...
April 2010: American Journal of Clinical Nutrition
Salma Kiani, Richard J Staples, S Ted Treves, Alan B Packard
As part of our on-going effort to develop (64)Cu-based radiopharmaceuticals for PET (positron emission tomography) imaging of multidrug resistance in cancer, we prepared a tetramethylfuranone-functionalized diiminedioxime ligand, TMFPreH (TMFPreH = 4-[3-(4-Hydroxyimino-2,2,5,5-dimethyl-dihydro-furan-3-ylideneamino)-propylimino]-2,2,5,5-tetramethyl-dihydro-furan-3-one oxime) and its Cu(II) and Ni(II) complexes. When the copper(II) complex was prepared from Cu(ClO(4))(2) in ethanol, it was isolated as a Cu(II)-bridged dimer, but when it was prepared from Cu(OAc)(2) and heated in acetone, an unusual example of an acetone adduct of the ligand is formed by reduction of one of the imine double bonds by the solvent...
March 12, 2009: Polyhedron
Maria Ogrzewalska, Richard C Pacheco, Alexandre Uezu, Leonardo J Richtzenhain, Fernando Ferreira, Marcelo B Labruna
Brazil has the third richest bird diversity of the world; however, there are few data concerning ticks (Acari: Ixodidae) parazitizing birds. The aim of the study was to report tick infestations on wild birds from an Atlantic rain forest region of Brazil. During 2 yr, ticks were collected from birds and from the environment in 12 forest sites. A total of 1,725 birds were captured representing 80 species from 24 families. In total, 223 (13%) birds were found infested by immature stages of Amblyomma ticks: 1,800 larvae and 539 nymphs...
September 2009: Journal of Medical Entomology
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