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https://www.readbyqxmd.com/read/27926811/p22phox-c242t-gene-polymorphism-and-overt-diabetic-nephropathy-a-meta-analysis-of-1-452-participants
#1
Yan-Yan Li, Ge Gong, Hong-Yu Geng, Yun Qian
Background/Aims: The p22phox C242T gene polymorphism (rs4673) may be linked to an increased susceptibility for overt diabetic nephropathy (ODN), but the study results are still inconclusive. Methods: To explore the relationship between p22phox C242T gene polymorphism and ODN, the current meta-analysis of 707 ODN patients and 745 controls from five individual studies was conducted. The pooled odds ratio (OR) and its corresponding 95% confidence interval (CI) were evaluated by either a random or fixed effect model...
December 8, 2016: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/27914709/podocyte-specific-chemokine-c-c-motif-receptor-2%C3%A2-overexpression-mediates-diabetic-renal-injury-in%C3%A2-mice
#2
Hanning You, Ting Gao, Wesley M Raup-Konsavage, Timothy K Cooper, Sarah K Bronson, W Brian Reeves, Alaa S Awad
Inflammation is a central pathophysiologic mechanism that contributes to diabetes mellitus and diabetic nephropathy. Recently, we showed that macrophages directly contribute to diabetic renal injury and that pharmacological blockade or genetic deficiency of chemokine (C-C motif) receptor 2 (CCR2) confers kidney protection in diabetic nephropathy. However, the direct role of CCR2 in kidney-derived cells such as podocytes in diabetic nephropathy remains unclear. To study this, we developed a transgenic mouse model expressing CCR2 specifically in podocytes (Tg[NPHS2-Ccr2]) on a nephropathy-prone (DBA/2J) and CCR2-deficient (Ccr2(-/-)) background with heterozygous Ccr2(+/-) littermate controls...
November 30, 2016: Kidney International
https://www.readbyqxmd.com/read/27881924/rodent-models-of-diabetic-nephropathy-their-utility-and-limitations
#3
REVIEW
Munehiro Kitada, Yoshio Ogura, Daisuke Koya
Diabetic nephropathy is the most common cause of end-stage renal disease. Therefore, novel therapies for the suppression of diabetic nephropathy must be developed. Rodent models are useful for elucidating the pathogenesis of diseases and testing novel therapies, and many type 1 and type 2 diabetic rodent models have been established for the study of diabetes and diabetic complications. Streptozotocin (STZ)-induced diabetic animals are widely used as a model of type 1 diabetes. Akita diabetic mice that have an Ins2+/C96Y mutation and OVE26 mice that overexpress calmodulin in pancreatic β-cells serve as a genetic model of type 1 diabetes...
2016: International Journal of Nephrology and Renovascular Disease
https://www.readbyqxmd.com/read/27833523/role-of-cytogenetic-biomarkers-in-management-of-chronic-kidney-disease-patients-a-review
#4
REVIEW
Zeba Khan, Manoj Pandey, Ravindra M Samartha
Chronic kidney disease (CKD) is much more common than people recognize, and habitually goes undetected and undiagnosed until the disease is well advanced or when their kidney functions is down to 25% of normal function. Genetic and non-genetic factors contribute to cause CKD. Non-genetic factors include hypertension, High level of DNA damage due to the production of reactive oxygen species and nucleic acid oxidation has been reported in CKD patients. Main genetic factor which causes CKD is diabetic nephropathy...
October 2016: International Journal of Health Sciences
https://www.readbyqxmd.com/read/27830089/proteasome-activators-pa28%C3%AE-and-pa28%C3%AE-govern-development-of-microvascular-injury-in-diabetic-nephropathy-and-retinopathy
#5
Saeed Yadranji Aghdam, Ali Mahmoudpour
Diabetic nephropathy (DN) and diabetic retinopathy (DR) are major complications of type 1 and type 2 diabetes. DN and DR are mainly caused by injury to the perivascular supporting cells, the mesangial cells within the glomerulus, and the pericytes in the retina. The genes and molecular mechanisms predisposing retinal and glomerular pericytes to diabetic injury are poorly characterized. In this study, the genetic deletion of proteasome activator genes, PA28α and PA28β genes, protected the diabetic mice in the experimental STZ-induced diabetes model against renal injury and retinal microvascular injury and prolonged their survival compared with wild type STZ diabetic mice...
2016: International Journal of Nephrology
https://www.readbyqxmd.com/read/27774826/mesenchymal-stem-cells-a-future-experimental-exploration-for-recession-of-diabetic-nephropathy
#6
Amal H Hamza, Widad M Al-Bishri, Laila A Damiati, Hanaa H Ahmed
BACKGROUND: The progresses made in stem cell therapy offer an innovative approach and exhibit great potential for the repair of damaged organs and tissues. This study was conducted with a view to find the mechanisms responsible for the effectiveness of bone marrow-derived mesenchymal stem cells (BM-MSCs) in the suppression of diabetes and experimentally-induced diabetic nephropathy. METHODS: To realize this objective, diabetic and diabetic nephropathy subject groups that underwent MSC treatment were studied through numerous biochemistry and molecular genetics analyses...
October 23, 2016: Renal Failure
https://www.readbyqxmd.com/read/27754025/yia-03-01-validation-of-genetic-determinants-of-unmet-needs-in-the-treatment-of-kidney-disease-in-type-2-diabetes
#7
Paul Simon, Aelna Krajčoviechová, Francois Harvey, Mousnif Haloui, Francois-Christophe Marois-Blanchet, John Chalmers, Mark Woodward, Michel Marre, Johanne Tremblay, Pavel Hamet
OBJECTIVE: We have previously reported the genetic determinants of unmet renal needs in Type 2 Diabetic (T2D) patients of the ADVANCE study (Abstract 0105-PD, IDF - World Diabetes Congress, Vancouver, 2015). We report here the external validation of several of these loci. An improved knowledge of the genetics linked to worsening diabetic nephropathy will offer insights on how to better manage this complication of diabetes and hypertension in T2D patients. DESIGN AND METHOD: We investigated 3,500 T2D patients of Caucasian origin included in the ADVANCE trial who were all treated with current standard therapies...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27721376/diabetic-nephropathy-the-genetic-architecture-of-dkd-in-t1dm
#8
Ellen F Carney
No abstract text is available yet for this article.
December 2016: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/27706190/influence-of-different-levels-of-lipoic-acid-synthase-gene-expression-on-diabetic-nephropathy
#9
Longquan Xu, Sylvia Hiller, Stephen Simington, Volker Nickeleit, Nobuyo Maeda, Leighton R James, Xianwen Yi
Oxidative stress is implicated in the pathogenesis of diabetic nephropathy (DN) but outcomes of many clinical trials are controversial. To define the role of antioxidants in kidney protection during the development of diabetic nephropathy, we have generated a novel genetic antioxidant mouse model with over- or under-expression of lipoic acid synthase gene (Lias). These models have been mated with Ins2Akita/+ mice, a type I diabetic mouse model. We compare the major pathologic changes and oxidative stress status in two new strains of the mice with controls...
2016: PloS One
https://www.readbyqxmd.com/read/27699784/association-of-rs11643718-slc12a3-and-rs741301-elmo1-variants-with-diabetic-nephropathy-in-south-indian-population
#10
Dhanasekaran Bodhini, Manickam Chidambaram, Samuel Liju, Balakannan Revathi, Dhandapani Laasya, Natarajan Sathish, Sekar Kanthimathi, Saurabh Ghosh, Ranjit Mohan Anjana, Viswanathan Mohan, Venkatesan Radha
This study reports on the association of genetic variants selected from previous genome-wide association studies for type 2 diabetic nephropathy in south Indians. Eight variants were genotyped in 601 type 2 diabetic subjects without nephropathy (DM) and 583 type 2 diabetic subjects with nephropathy (DN) by MassARRAY. The minor allele frequencies of rs11643718 SLC12A3 variant and rs741301 ELMO1 variant were significantly different between DM and DN groups (P = 0.029 and 0.016, respectively). A combined analysis showed that the subjects carrying the risk genotypes of both these variants (GG of rs11643718 + AG/AA of rs741301) had a significant association with DN with an odds ratio [adjusted for age, sex, Body Mass Index (BMI), HbA1c, and systolic Blood Pressure (BP)] of 1...
November 2016: Annals of Human Genetics
https://www.readbyqxmd.com/read/27679717/cardiovascular-renal-complications-and-the-possible-role-of-plasminogen-activator-inhibitor-a-review
#11
John A D'Elia, George Bayliss, Ray E Gleason, Larry A Weinrauch
Since angiotensin increases the expression of plasminogen activator inhibitor (PAI), mechanisms associated with an actively functioning renin-angiotensin-aldosterone system can be expected to be associated with increased PAI-1 expression. These mechanisms are present not only in common conditions resulting in glomerulosclerosis associated with aging, diabetes or genetic mutations, but also in autoimmune disease (like scleroderma and lupus), radiation injury, cyclosporine toxicity, allograft nephropathy and ureteral obstruction...
October 2016: Clinical Kidney Journal
https://www.readbyqxmd.com/read/27661054/the-effects-of-cyp2c19-genotype-on-the-susceptibility-for-nephrosis-in-cardio-cerebral-vascular-disease-treated-by-anticoagulation
#12
Kai Chang, Zhongyong Jiang, Chenxia Liu, Junlong Ren, Ting Wang, Jie Xiong
In recent years, the genetic factor has become one of the important predisposing factors of nephropathy susceptibility. There is a high incidence of nephropathy in CCVd. The CYP2C19 enzyme metabolizes most the drugs, including proton pump inhibitors commonly used medicines to treat CCVd, CYP2C19 genetic polymorphisms is association with multi-pathogenesis factors of nephropathy. The purpose of the study is to reveal the association between CYP2C19 genotype and the susceptibility of nephropathy in the CCVd patients...
September 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27642943/yia-03-01-validation-of-genetic-determinants-of-unmet-needs-in-the-treatment-of-kidney-disease-in-type-2-diabetes
#13
Paul Simon, Aelna Krajčoviechová, Francois Harvey, Mousnif Haloui, Francois-Christophe Marois-Blanchet, John Chalmers, Mark Woodward, Michel Marre, Johanne Tremblay, Pavel Hamet
OBJECTIVE: We have previously reported the genetic determinants of unmet renal needs in Type 2 Diabetic (T2D) patients of the ADVANCE study (Abstract 0105-PD, IDF - World Diabetes Congress, Vancouver, 2015). We report here the external validation of several of these loci. An improved knowledge of the genetics linked to worsening diabetic nephropathy will offer insights on how to better manage this complication of diabetes and hypertension in T2D patients. DESIGN AND METHOD: We investigated 3,500 T2D patients of Caucasian origin included in the ADVANCE trial who were all treated with current standard therapies...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27612613/association-of-chemerin-and-vascular-endothelial-growth-factor-vegf-with-diabetic-nephropathy
#14
Shuhua Lin, Jian Teng, Jixia Li, Fang Sun, Dong Yuan, Jing Chang
BACKGROUND Diabetic nephropathy (DN) is a common complication of diabetes, caused by diabetic microvascular lesions. The pathogenesis of DN is complicated, involving genetics, physics, chemistry, and environmental factors. Chemerin is a fat cell factor that participates in regulating inflammation. Vascular endothelial growth factor (VEGF) promotes vascular endothelial cell proliferation, differentiation, and angiogenesis. The relationship role of Chemerin and VEGF in DN is not fully understood. MATERIAL AND METHODS SD rats were randomly divided into 2 groups: the control group and the DN group...
2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27508793/-op-6d-04-association-study-of-angiotensinase-a-enpep-genotype-with-diabetic-nephropathy
#15
T Konoshita, A Sakai, S Kaeriyama, M Urabe, T Nakaya, M Yamada, M Ichikawa, S Sato, K Yamamoto, M Imagawa, M Fujii, Y Zenimaru, J Suzuki, Y Makino, T Ishizuka, N Kato
OBJECTIVE: It is well known that the renin angiotensin system (RAS) plays a pivotal role in the development of diabetic nephropathy (DMN). Recent genome-wide association studies have identified a number of common genetic variants associated with blood pressure variation in east Asians. One of such loci is angiotensinase A (ENPEP), which converts the angiotensin II to angiotensin III in the RAS. We therefore tested the hypothesis that genetic variants of ENPEP could show significant association with prevalence of DMN...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27500547/interleukin-6-gene-polymorphisms-correlate-with-the-progression-of-nephropathy-in-chinese-patients-with-type-2-diabetes-a-prospective-cohort-study
#16
Wen-Tsan Chang, Meng-Chuan Huang, Hsin-Fang Chung, Yen-Feng Chiu, Pao-Shan Chen, Fang-Pei Chen, Chun-Yi Lee, Shyi-Jang Shin, Shang-Jyh Hwang, Ya-Fang Huang, Chih-Cheng Hsu
AIMS: Interleukin-6 (IL-6), an inflammatory cytokine, is considered a candidate gene possibly involved in susceptibility to nephropathy in diabetes. This study aimed to examine whether IL-6 polymorphisms predict the progression of nephropathy in a prospective Chinese cohort of patients with type 2 diabetes. METHODS: A total of 568 type 2 diabetic patients with normoalbuminuria at baseline were followed up for a mean of 5.3±1.5years. Urinary albumin-to-creatinine ratio (ACR) ⩾30mg/g in two consecutive urine tests were defined as progression to diabetic nephropathy (n=143)...
October 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/27498976/association-of-angiotensin-converting-enzyme-insertion-deletion-polymorphism-with-type-1-diabetic-nephropathy-a-meta-analysis
#17
Hai-Yan Xu, Ming-Ming Liu, Xu Wang, Xue-Yuan He
OBJECTIVE: This study aimed to systematically evaluate the effect of an angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism on type 1 diabetic nephropathy (DN). METHODS: Cochrane Library, Embase, PubMed, Science Direct, Web of science, Wanfang data, VIP database, China Knowledge Resource Integrated Database, and SinoMed were searched. A total of 17 case-control studies analyzing ACE I/D polymorphism and type 1 DN risk were included in the present meta-analysis...
August 8, 2016: Renal Failure
https://www.readbyqxmd.com/read/27490827/discovery-and-preclinical-characterization-of-6-chloro-5-4-1-hydroxycyclobutyl-phenyl-1h-indole-3-carboxylic-acid-pf-06409577-a-direct-activator-of-adenosine-monophosphate-activated-protein-kinase-ampk-for-the-potential-treatment-of-diabetic-nephropathy
#18
Kimberly O Cameron, Daniel W Kung, Amit S Kalgutkar, Ravi G Kurumbail, Russell Miller, Christopher T Salatto, Jessica Ward, Jane M Withka, Samit K Bhattacharya, Markus Boehm, Kris A Borzilleri, Janice A Brown, Matthew Calabrese, Nicole L Caspers, Emily Cokorinos, Edward L Conn, Matthew S Dowling, David J Edmonds, Heather Eng, Dilinie P Fernando, Richard Frisbie, David Hepworth, James Landro, Yuxia Mao, Francis Rajamohan, Allan R Reyes, Colin R Rose, Tim Ryder, Andre Shavnya, Aaron C Smith, Meihua Tu, Angela C Wolford, Jun Xiao
Adenosine monophosphate-activated protein kinase (AMPK) is a protein kinase involved in maintaining energy homeostasis within cells. On the basis of human genetic association data, AMPK activators were pursued for the treatment of diabetic nephropathy. Identification of an indazole amide high throughput screening (HTS) hit followed by truncation to its minimal pharmacophore provided an indazole acid lead compound. Optimization of the core and aryl appendage improved oral absorption and culminated in the identification of indole acid, PF-06409577 (7)...
September 8, 2016: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27489899/-diabetes-mellitus-and-chronic-kidney-disease-possibilities-of-prediction-early-diagnosis-and-nephroprotection-in-the-21st-century
#19
REVIEW
M V Shestakova
The. review gives data on the prognostic value of genetic markers when analyzing the risk of chronic kidney disease in diabetes mellitus, those on new possibilities of early diagnosis of diabetic nephropathy using urinary biomarkers (nephrinuria, podocinuria) and proteomic urinalysis at the stage of normoalbuminuria. The interpretation of the index mrcroalbuminuria in type 2 diabetesis critically analyzed. The nephroprotective properties of novel classes of glucose-lowering drugs, such as incretins and gliflozins, are considered...
2016: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/27461219/association-of-kidney-structure-related-gene-variants-with-type-2-diabetes-attributed-end-stage-kidney-disease-in-african-americans
#20
Meijian Guan, Jun Ma, Jacob M Keaton, Latchezar Dimitrov, Poorva Mudgal, Mary Stromberg, Jason A Bonomo, Pamela J Hicks, Barry I Freedman, Donald W Bowden, Maggie C Y Ng
African Americans (AAs) are at higher risk for developing end-stage kidney disease (ESKD) compared to European Americans. Genome-wide association studies have identified variants associated with diabetic and non-diabetic kidney diseases. Nephropathy loci, including SLC7A9, UMOD, and SHROOM3, have been implicated in the maintenance of normal glomerular and renal tubular structure and function. Herein, 47 genes important in podocyte, glomerular basement membrane, mesangial cell, mesangial matrix, renal tubular cell, and renal interstitium structure were examined for association with type 2 diabetes (T2D)-attributed ESKD in AAs...
November 2016: Human Genetics
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