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https://www.readbyqxmd.com/read/29678354/actin-dynamics-at-focal-adhesions-a-common-endpoint-and-putative-therapeutic-target-for-proteinuric-kidney-diseases
#1
REVIEW
Sanja Sever, Mario Schiffer
Proteinuria encompasses diverse causes including both genetic diseases and acquired forms such as diabetic and hypertensive nephropathy. The basis of proteinuria is a disturbance in size selectivity of the glomerular filtration barrier, which largely depends on the podocyte: a terminally differentiated epithelial cell type covering the outer surface of the glomerulus. Compromised podocyte structure is one of the earliest signs of glomerular injury. The phenotype of diverse animal models and podocyte cell culture firmly established the essential role of the actin cytoskeleton in maintaining functional podocyte structure...
April 17, 2018: Kidney International
https://www.readbyqxmd.com/read/29652635/far2-is-associated-with-kidney-disease-in-mice-and-humans
#2
Grant Backer, Sean Eddy, Susan M Sheehan, Yuka Takemon, Anna Reznichenko, Holly S Savage, Matthias Kretzler, Ron Korstanje
Mesangial matrix expansion is an important process in the initiation of chronic kidney disease, yet the genetic factors driving its development are unknown. Our previous studies have implicated Far2 as a candidate gene associated with differences in mesangial matrix expansion between mouse inbred strains. Consistent with the hypothesis that increased expression of Far2 leads to mesangial matrix expansion through increased production of platelet-activating factor precursors, we show that FAR2 is capable of mediating de novo platelet-activating factor synthesis in vitro and driven by the transcription factor NKX3...
April 13, 2018: Physiological Genomics
https://www.readbyqxmd.com/read/29651674/intestinal-microbiota-and-kidney-diseases
#3
Ao Xie, Jie Sheng, Feng Zheng
Kidney diseases are common and the incidence rate is increasing. Gut microbiota is involved in metabolic and immune regulation of the host. Genetic, alimentary and environmental disease factors may change gut flora and increase opportunistic and pathogenic bacteria, contributing to immune or non-immune mediated kidney diseases including IgA nephropathy and diabetic nephropathy. Additionally, bacterial metabolites may be a source of uremic toxins. Thus, identififi cation of diversity, composition, and metabolic and immunologic features of gut bacteria in chronic kidney diseases may help understand pathogenetic mechanism and develop therapy for diseases...
April 12, 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29629376/association-of-ephx2-r287q-polymorphism-with-diabetic-nephropathy-in-chinese-type-2-diabetic-patients
#4
Liang Ma, Meihua Yan, Xiaomu Kong, Yongwei Jiang, Tingting Zhao, Hailing Zhao, Qian Liu, Haojun Zhang, Peng Liu, Yongtong Cao, Ping Li
The aim of this study was to investigate the relationship between EPHX2 rs751141 (R287Q polymorphism) and diabetic nephropathy (DN) in Chinese type 2 diabetes (T2D). This case-control study explored the association between EPHX2 rs751141 and DN in a total of 870 Chinese T2D patients (406 T2D patients with DN and 464 T2D patients without DN). DNA was extracted from peripheral leukocytes of the patients and rs751141 was genotyped. The A allele frequency of rs751141 was significantly lower in DN patients (20.94%) compared with non-DN controls (27...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29626590/altered-expression-of-wfs1-and-notch2-genes-associated-with-diabetic-nephropathy-in-t2dm-patients
#5
Sahar A Sharaf, Nagwa A Kantoush, Dina F Ayoub, Alshaymaa A Ibrahim, Amaal A Abdelaal, Rokaya Abdel Aziz, Mahmoud M ElHefnawi, Amira N Ahmed
AIM: The increased incidence of type 2 diabetes mellitus (T2DM) and the importance of early identification and management of its complications, especially diabetic nephropathy (DN), have spotted the light on genetic factors that increase risk of T2DM and its related nephropathy. The present study aimed at investigating expression of (KCNJ11, ABCC8, JAZF1, WFS1, PPARG, NOTCH2 and EXOSC4) genes in peripheral blood of T2DM patients. METHOD: The study included 30 non-complicated T2DM patients, 30 patients with DN and 40 healthy controls...
April 4, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29605608/genetic-variations-in-key-inflammatory-cytokines-exacerbates-the-risk-of-diabetic-nephropathy-by-influencing-the-gene-expression
#6
Iqra Hameed, Shariq R Masoodi, Perveez A Malik, Shahnaz A Mir, Khalid Ghazanfar, Bashir A Ganai
BACKGROUND: Diabetic nephropathy is the single strongest predictor of mortality in patients with diabetes. The development of overt nephropathy involves important inter-individual variations, even after adjusting for potential confounding influences of modifiable and non-modifiable risk factors. Genome-wide transcriptome studies have reported the activation of inflammatory signaling pathways and there is mounting indication of the role of genetic factors. METHODS: We screened nine genetic variations in three cytokine genes (TNF-α, IL-6 and IL-β) in 1326 unrelated subjects comprising of healthy controls (n = 464), type 2 diabetics with nephropathy (DN, n = 448) and type 2 diabetes without nephropathy (T2D, n = 414) by sequence-specific amplification...
March 29, 2018: Gene
https://www.readbyqxmd.com/read/29574544/preservation-of-renal-function-in-chronic-diabetes-by-enhancing-glomerular-glucose-metabolism
#7
REVIEW
Weier Qi, Qian Li, Daniel Gordin, George L King
Diabetic nephropathy (DN) affects approximately 30-40% of patients with type 1 (T1DM) and type 2 diabetes (T2DM). It is a major cause of end-stage renal disease (ESRD) for the developed world. Hyperglycemia and genetics are major causal factors for the initiation and progression of DN. Multiple abnormalities in glucose and mitochondrial metabolism induced by diabetes likely contribute to the severity of DN. Recent clinical studies in people with extreme duration of T1DM (> 50 years, Joslin Medalist Study) have supported the importance of endogenous protective factors to neutralize the toxic effects of hyperglycemia on renal and other vascular tissues...
March 24, 2018: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/29572389/nicotine-enhances-mesangial-cell-proliferation-and-fibronectin-production-in-high-glucose-milieu-via-activation-of-wnt-%C3%AE-catenin-pathway
#8
Xiqian Lan, Hongxiu Wen, Rukhsana Aslam, Seyedeh Shadafarin Marashi Shoshtari, Abheepsa Mishra, Vinod Kumar, Haichao Wang, Guisheng Wu, Huairong Luo, Ashwani Malhotra, Pravin C Singhal
Diabetic nephropathy (DN) is a major complication of diabetes mellitus. Clinic reports indicate cigarette smoking is an independent risk factor for chronic kidney disease including DN; however, the underlying molecular mechanisms are not clear. Recent studies have demonstrated that nicotine, one of the active compounds in cigarette smoke, contributes to the pathogenesis of the cigarette smoking-accelerated chronic kidney disease. One of the characteristics of DN is the expansion of mesangium, a precursor of glomerular sclerosis...
March 23, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29523280/can-thrombophilia-worsen-maternal-and-perinatal-outcomes-in-cases-of-severe-preeclampsia
#9
Fernanda Spadotto Baptista, Maria Rita de Figueiredo Lemos Bortolotto, Fabiola Roberta Marim Bianchini, Vera Lucia Jornada Krebs, Marcelo Zugaib, Rossana Pulcinelli Vieira Francisco
OBJECTIVE: To evaluate whether thrombophilia worsens maternal and foetal outcomes among patients with severe preeclampsia (PE). METHOD: From October 2009 to October 2014, an observational retrospective cohort study was performed on pregnant women with severe PE diagnosed before 34 weeks of gestation and their newborns hospitalized at the Clinics Hospital, FMUSP. Patients who had no heart disease, nephropathies, pre-gestational diabetes, gestational trophoblastic disease, foetal malformation, or twin pregnancy and who underwent thrombophilia screening during the postnatal period were included...
January 2018: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29462715/a-new-model-of-diabetic-nephropathy-in-c57bl-6-mice-challenged-with-advanced-oxidation-protein-products
#10
Xiaoyan Bai, Xiao Li, Jianwei Tian, Liting Xu, Jiao Wan, Youhua Liu
There remains a lack of robust mouse models with key features of advanced human diabetic nephropathy (DN). Few options of murine models of DN require mutations to be superimposed to obtain desired phenotypic characteristics. Most genetically modified mice are on the C57BL/6 background; however, they are notorious for resistance to develop DN. To overcome these conundrums, this study reports a novel DN model by challenging with advanced oxidation protein products (AOPPs) in streptozotocin-induced diabetic C57BL/6 mice...
February 17, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29410390/genes-associated-with-type-2-diabetes-and-vascular-complications
#11
Alberto Montesanto, Anna Rita Bonfigli, Paolina Crocco, Paolo Garagnani, Maria De Luca, Massimo Boemi, Elena Marasco, Chiara Pirazzini, Cristina Giuliani, Claudio Franceschi, Giuseppe Passarino, Roberto Testa, Fabiola Olivieri, Giuseppina Rose
Type 2 Diabetes (T2D) is a chronic disease associated with a number of micro- and macrovascular complications that increase the morbidity and mortality of patients. The risk of diabetic complications has a strong genetic component. To this end, we sought to evaluate the association of 40 single nucleotide polymorphisms (SNPs) in 21 candidate genes with T2D and its vascular complications in 503 T2D patients and 580 healthy controls. The genes were chosen because previously reported to be associated with T2D complications and/or with the aging process...
February 4, 2018: Aging
https://www.readbyqxmd.com/read/29404926/synergistical-action-of-the-%C3%AE-2-adrenoceptor-and-fatty-acid-binding-protein-2-polymorphisms-on-the-loss-of-glomerular-filtration-rate-in-chinese-patients-with-type-2-diabetic-nephropathy
#12
Tao Wang, Yan Zhang, Ning Wang, Qiong Liu, ZeKai Wang, Bing Liu, Kai Niu
PURPOSE: Since altered sympathetic nerve activity and insulin resistance are implicated in the pathogenesis of type 2 diabetic nephropathy, we investigated the effect of polymorphic Arg16Gly and Gln27Glu in the β2 adrenoceptor gene and Ala54Thr in the fatty acid binding protein 2 gene on the estimated glomerular filtration rate (eGFR) in Chinese patients with the above disease. METHODS: A total of 552 diabetic subjects recruited from annual health examinations were studied...
February 5, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29393086/uric-acid-the-unknown-uremic-toxin
#13
Alejandro Treviño-Becerra
This review brings together concepts of uric acid metabolism affecting renal parenchyma and its function and the current therapies to reduce hyperuricemia (HyU) and avoid renal disease progression. High uric acid plays an important role in several chronic diseases including kidney diseases such as lithiasis, gout nephropathy, and preeclampsia. In the last 30 years, it has been shown that reducing HyU with low protein and low purine diets in addition to allopurinol creates physiopathological conditions that produce a slight increase in the glomerular filtration rate (GFR)...
2018: Contributions to Nephrology
https://www.readbyqxmd.com/read/29282014/spectrum-characteristics-of-patients-with-chronic-kidney-disease-ckd-with-increasing-age-in-a-major-metropolitan-renal-service
#14
Usman Mahmood, Helen G Healy, Adrian Kark, Anne Cameron, Zaimin Wang, Rajitha Abeysekera, Wendy E Hoy
BACKGROUND: Aim of our study is to describe, in people with CKD, the demographic and clinical characteristics and outcomes with increasing age. The prevalence of CKD in Western populations, where longevity is the norm, is about 10-15%, but how age influence different characteristics of patients with CKD is largely not known. METHODS: One thousand two hundred sixty-five patients enrolled in the CKD.QLD registry at the Royal Brisbane and Women's Hospital were grouped according to age at consent i...
December 28, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/29242368/lessons-from-ckd-related-genetic-association-studies-moving-forward
#15
Sophie Limou, Nicolas Vince, Afshin Parsa
Over the past decade, genetic association studies have uncovered numerous determinants of kidney function in the general, diabetic, hypertensive, CKD, ESRD, and GN-based study populations ( e.g. , IgA nephropathy, membranous nephropathy, FSGS). These studies have led to numerous novel and unanticipated findings, which are helping improve our understanding of factors and pathways affecting both normal and pathologic kidney function. In this review, we report on major discoveries and advances resulting from this rapidly progressing research domain...
January 6, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29211853/nrf2-deficiency-upregulates-intrarenal-angiotensin-converting-enzyme-2-and-angiotensin-1-7-receptor-expression-and-attenuates-hypertension-and-nephropathy-in-diabetic-mice
#16
Shuiling Zhao, Anindya Ghosh, Chao-Sheng Lo, Isabelle Chenier, James W Scholey, Janos G Filep, Julie R Ingelfinger, Shao-Ling Zhang, John S D Chan
We investigated the role of nuclear factor erythroid 2-related factor 2 (Nrf2) in renin-angiotensin system (RAS) gene expression in renal proximal tubule cells (RPTCs) and in the development of systemic hypertension and kidney injury in diabetic Akita mice. We used adult male Akita Nrf2 knockout mice and Akita mice treated with trigonelline (an Nrf2 inhibitor) or oltipraz (an Nrf2 activator). We also examined rat immortalized RPTCs (IRPTCs) stably transfected with control plasmids or plasmids containing rat angiotensinogen (Agt), angiotensin-converting enzyme (ACE), angiotensin-converting enzyme-2 (Ace2), or angiotensin 1-7 (Ang 1-7) receptor (MasR) gene promoters...
February 1, 2018: Endocrinology
https://www.readbyqxmd.com/read/29207384/slc2a1-tag-snps-in-greek-patients-with-diabetic-retinopathy-and-nephropathy
#17
Vasileios Siokas, Anatoli Fotiadou, Efthimios Dardiotis, Maria G Kotoula, Sophia V Tachmitzi, Dimitrios Z Chatzoulis, Elias Zintzaras, Ioannis Stefanidis, Evangelia E Tsironi
Backround: Genetic variants are implicated in the development of diabetic retinopathy (DR) and nephropathy (DN). The role of solute carrier family 2-facilitated glucose transporter member 1 (SLC2A1), also known as glucose transporter (GLUT1), on DR and DN remain controversial. OBJECTIVE: Examination of the influence of tag SLC2A1 single-nucleotide polymorphisms (SNPs) on the development of DR and DN during the course of type 2 diabetes mellitus (T2DM). METHODS: A total of 169 patients with DR or DN, 107 uncomplicated T2DM patients, and 315 controls were recruited and genotyped for 14 SLC2A1 tag SNPs...
December 6, 2017: Ophthalmic Research
https://www.readbyqxmd.com/read/29205998/diabetic-nephropathy-in-type-1-diabetes
#18
Nektaria Papadopoulou-Marketou, Stavroula A Paschou, Nikolaos Marketos, Sofia Adamidi, Sotiris Adamidis, Christina Kanaka-Gantenbein
Diabetic nephropathy (DN) also named diabetic kidney disease (DN) is one of the leading causes of mortality in people with diabetes. The aim of this review is to update the medical literature, the theories behind its early natural history, the pathways of its pathogenesis, its diagnosis and treatment. Poor glycemic control, hyperlipidemia, smoking, oxidative stress, accumulation of advanced glycated end products, environmental, genetic and epigenetic factors play an important role in the pathophysiological development of DN...
December 4, 2017: Minerva Medica
https://www.readbyqxmd.com/read/29196930/association-of-alox12-gene-polymorphism-with-all-cause-and-cardiovascular-mortality-in-diabetic-nephropathy
#19
Athanasios K Roumeliotis, Stefanos K Roumeliotis, Stylianos A Panagoutsos, Fotis Tsetsos, Marianthi Georgitsi, Vangelis Manolopoulos, Peristera Paschou, Ploumis S Passadakis
PURPOSE: Cardiovascular (CV) events are the first cause of death in patients with chronic renal disease (CKD) and in patients with type 2 diabetes mellitus (DM2). The combination of CKD and DM2 elevates the risk of both cardiovascular disease (CVD) and death in this high-risk population. Besides traditional risk factors, such as dyslipidemia, smoking, obesity, and carotid atherosclerosis, novel factors are under investigation such as genetic polymorphisms. Lipoxygenases (LOXs) and their genes are of critical importance in oxidative stress, inflammation, and atherosclerosis...
February 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29158465/tonicity-responsive-enhancer-binding-protein-mediates-hyperglycemia-induced-inflammation-and-vascular-and-renal-injury
#20
Soo Youn Choi, Sun Woo Lim, Shabnam Salimi, Eun Jin Yoo, Whaseon Lee-Kwon, Hwan Hee Lee, Jun Ho Lee, Braxton D Mitchell, Satoru Sanada, Afshin Parsa, Hyug Moo Kwon
Diabetic nephropathy (DN) has become the single leading cause of ESRD in developed nations. Bearing in mind the paucity of effective treatment for DN and progressive CKD, novel targets for treatment are sorely needed. We previously reported that increased activity of tonicity-responsive enhancer-binding protein (TonEBP) in monocytes was associated with early DN in humans. We now extend these findings by testing the hypotheses that TonEBP in macrophages promotes hyperglycemia-mediated proinflammatory activation and chronic renal inflammation leading to DN and CKD, and TonEBP genetic variability in humans is associated with inflammatory, renal, and vascular function-related phenotypes...
February 2018: Journal of the American Society of Nephrology: JASN
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