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https://www.readbyqxmd.com/read/27928636/effects-of-lanthanum-carbonate-and-calcium-carbonate-on-fibroblast-growth-factor-23-and-hepcidin-levels-in-chronic-hemodialysis-patients
#1
Yu-Ming Chang, Shih-Ching Tsai, Chih-Chung Shiao, Hung-Hsiang Liou, Chuan-Lan Yang, Nai-Yu Tung, Kua-Sui Hsu, I-Ling Chen, Mei-Chyn Liu, Jsun-Liang Kao, Rong-Na Jhen, Ya-Ting Huang
BACKGROUND: Phosphate binders have an impact on fibroblast growth factor 23 (FGF23); however, the effect of phosphate binders on serum hepcidin has not been explored. We conducted a 24-week multicenter randomized controlled trial to investigate the effects of lanthanum carbonate or calcium carbonate monotherapy on serum phosphate, FGF23, and hepcidin levels in chronic hemodialysis patients. METHODS: Forty-six patients were recruited, and daily dietary phosphorus was controlled between 600-800 mg...
December 7, 2016: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/27928454/the-role-of-oral-sodium-bicarbonate-supplementation-in-maintaining-acid-base-balance-and-its-influence-on-the-cardiovascular-system-in-chronic-hemodialysis-patients-results-of-a-prospective-study
#2
Voiculeț C, Zară O, Bogeanu C, Văcăroiu I, Aron G
Background: Major acid-base variations during dialysis and the imbalances in serum calcium levels intensified by them play a role in cardiovascular damage of hemodialysis patients. Early vascular walls modifications can be objectified by determining the pulse wave velocity (PWV) - a marker of vascular stiffness that is associated with increased risk of cardiovascular events. Material and methods: This was a prospective study conducted on 63 chronic hemodialysis patients with diuresis above 500 mL/ 24 hours and predialysis blood pressure below 160 mmHg (treatment controlled) randomized in two groups for 12 months - the study group receiving interdialitic oral sodium bicarbonate doses and control group, without oral sodium bicarbonate supplementation, but receiving higher bicarbonate prescriptions in dialysis...
October 2016: Journal of Medicine and Life
https://www.readbyqxmd.com/read/27928449/severe-asymptomatic-coronary-obstruction-in-chronic-hemodialysed-patient-a-case-report
#3
Voiculeț C, Zara O, Văcăroiu I, Bogeanu C, Tiron T, Turcu F, Aron G, Ciocâlteu A
Introduction. Arterial stiffness and vascular calcifications are independent predictors of cardiovascular morbidity and mortality in the chronic kidney disease (CKD) stage 5D population. According to the guidelines, patients on renal replacement therapy represent a very high cardiovascular risk class. Case report. We report the case of a 67-year-old hypertensive male patient, known with CKD stage 5D on hemodialysis (three times per week), secondary bone mineral disease, admitted for progressive right leg pain...
October 2016: Journal of Medicine and Life
https://www.readbyqxmd.com/read/27900314/renal-and-cardiovascular-morbidities-associated-with-apol1-status-among-african-american-and-non-african-american-children-with-focal-segmental-glomerulosclerosis
#4
Robert P Woroniecki, Derek K Ng, Sophie Limou, Cheryl A Winkler, Kimberly J Reidy, Mark Mitsnefes, Matthew G Sampson, Craig S Wong, Bradley A Warady, Susan L Furth, Jeffrey B Kopp, Frederick J Kaskel
BACKGROUND AND OBJECTIVES: African-American (AA) children with focal segmental glomerulosclerosis (FSGS) have later onset disease that progresses more rapidly than in non-AA children. It is unclear how APOL1 genotypes contribute to kidney disease risk, progression, and cardiovascular morbidity in children. DESIGN SETTING PARTICIPANTS AND MEASUREMENTS: We examined the prevalence of APOL1 genotypes and associated cardiovascular phenotypes among children with FSGS in the Chronic Kidney Disease in Children (CKiD) study; an ongoing multicenter prospective cohort study of children aged 1-16 years with mild to moderate kidney disease...
2016: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/27880946/2md-dp001-a-single-agent-in-the-management-of-hemodialysis-patients-a-randomized-trial
#5
Ravi Thadhani, Julia B Zella, Danielle C Knutson, William J Blaser, Lori A Plum, Margaret Clagett-Dame, Raymond D Buck, Hector F DeLuca
BACKGROUND: Vitamin D analogs and calcimimetics are used to manage secondary hyperparathyroidism (SHPT) in dialysis patients. DP001 is an oral vitamin D analog that suppresses parathyroid hormone (PTH) in uremic rats, osteopenic women, and hemodialysis patients. The safety and effectiveness of DP001 suppressing PTH in dialysis patients previously managed with active vitamin D with or without a calcimimetic are presented. METHODS: A multicenter, randomized, double-blind study compared DP001 to placebo in hemodialysis patients with serum-intact PTH (iPTH) ≥300 pg/ml...
November 24, 2016: American Journal of Nephrology
https://www.readbyqxmd.com/read/27867867/early-intact-pth-ipth-is-an-early-predictor-of-postoperative-hypocalcemia-for-a-safer-and-earlier-hospital-discharge-an-analysis-on-260-total-thyroidectomies
#6
REVIEW
Davide Inversini, Stefano Rausei, Cesare Carlo Ferrari, Francesco Frattini, Angkoon Anuwong, Hoon Yub Kim, Xiaoli Liu, Chei-Wei Wu, Wen Tian, Renbin Liu, Gianlorenzo Dionigi
BACKGROUND: Hypocalcemia is the most frequent complication after thyroidectomy. Serum calcium levels are reliable only 48-72 hours postoperatively. Early intact PTH (iPTH) has been proposed as early predictor of postoperative hypocalcemia. Our aim is to assess the ability of iPTH in predicting postoperative hypocalcemia. METHODS: Two hundred and sixty patients underwent thyroidectomy with postoperative iPTH evaluation. The iPTH samplings were early performed after thyroidectomy...
October 2016: Gland Surgery
https://www.readbyqxmd.com/read/27866377/unusual-cause-of-hypercalcaemia-in-end-stage-renal-failure-patients
#7
Hooi Khee Teo, Jiunn Wong
Immobility-induced hypercalcaemia is rarely considered in patients on dialysis and is a challenging diagnosis to make. This is especially so due to the lack of biomarkers as well as the notion that calcium metabolism is mostly related to chronic kidney disease-metabolic bone disorder due to the role of iPTH. We present two cases of our dialysis patients, who were clinically unwell from hypercalcemia. We were initially uncertain of the cause of hypercalcemia as despite our attempts to adjust treatment based on their biochemical findings, we were unable to correct the hypercalcemia...
November 20, 2016: Hemodialysis International
https://www.readbyqxmd.com/read/27689105/correlation-between-serum-leptin-and-bone-mineral-density-in-hemodialysis-patients
#8
Mahin Ghorban-Sabbagh, Fatemeh Nazemian, Massih Naghibi, Mohammad-Taghi Shakeri, Saeedeh Ahmadi-Simab, Reza Javidi-Dasht-Bayaz
INTRODUCTION: For diagnosing of specific types of bone lesions in hemodialysis (HD) patients, it is necessary to conduct a bone biopsy as the gold standard method. However, it is an invasive procedure. While different markers have been suggested as alternative methods, none of them has been selected. The frequency of hip fractures is 80 fold in HD patients who have two-fold mortality as compared with general population. OBJECTIVES: Recently, serum leptin has been suggested as a bone density marker...
2016: Journal of Renal Injury Prevention
https://www.readbyqxmd.com/read/27676085/use-of-extended-release-calcifediol-to-treat-secondary-hyperparathyroidism-in-stages-3-and-4-chronic-kidney-disease
#9
Stuart M Sprague, Paul W Crawford, Joel Z Melnick, Stephen A Strugnell, Shaukat Ali, Roberto Mangoo-Karim, Sungchun Lee, P Martin Petkovich, Charles W Bishop
BACKGROUND/AIMS: Vitamin D insufficiency and secondary hyperparathyroidism (SHPT) are associated with increased morbidity and mortality in chronic kidney disease (CKD) and are poorly addressed by current treatments. The present clinical studies evaluated extended-release (ER) calcifediol, a novel vitamin D prohormone repletion therapy designed to gradually correct low serum total 25-hydroxyvitamin D, improve SHPT control and minimize the induction of CYP24A1 and FGF23. METHODS: Two identical multicenter, randomized, double-blind, placebo-controlled studies enrolled subjects from 89 US sites...
September 28, 2016: American Journal of Nephrology
https://www.readbyqxmd.com/read/27642453/-valvular-calcifications-in-a-patient-on-hemodialysis-in-morocco
#10
Samia Ait Faqih, Béfa Noto-Kadou-Kaza, Lalla Meryam Abouamrane, Naoufal Mtiou, Selma El Khaya, Mohamed Zamd, Ghislaine Medkouri, Mohamed Gharbi Bengahanem, Benyounes Ramdani
INTRODUCTION: Valvular calcifications are one of the major cardiovascular complications of hemodialysis because of its prevalence and its predictive indices of morbidity and mortality. There are many risk factors associated with these calcifications. Our study aims to evaluate both the prevalence of valvular calcifications in our patients on hemodialysis and their risk factors. METHODS: This was a single-center cross-sectional descriptive and analytical study of 111 adult patients who were on hemodialysis for more than 6 months at the hemodialysis center CHU Ibn Rushd, Casablanca and who underwent ETT during the year 2013...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27558654/oral-iron-supplementation-with-sodium-ferrous-citrate-reduces-the-serum-intact-and-c-terminal-fgf23-levels-of-maintenance-hemodialysis-patients
#11
Kazuomi Yamashita, Sonoo Mizuiri, Yoshiko Nishizawa, Shigemoto Kenichiro, Shigehiro Doi, Takao Masaki
BACKGROUND/AIM: Iron deficiency stimulates fibroblast growth factor 23 (FGF23) transcription. This study aimed to determine whether oral ferrous iron (Fe(2+) ) reduces the serum FGF23 levels of iron-deficient maintenance hemodialysis (MHD) patients in the same way as oral ferric iron (Fe(3+) ). METHODS: Thirty-one MHD patients with iron deficiency were enrolled in this prospective study. Patients who had taken iron supplements during the 8 weeks before the study were excluded...
August 25, 2016: Nephrology
https://www.readbyqxmd.com/read/27537716/serum-fibroblastic-growth-factor-23-in-acute-sarcoidosis-and-normal-kidney-function
#12
Donal J Sexton, M W O'Reilly, P Geoghegan, S M Kinsella, P J Moran, A W O'Regan
BACKGROUND: Serum fibroblastic growth factor (FGF) 23 has recently been established as a major physiological regulator of phosphate homeostasis and may have a causal role in adverse cardiovascular and bone outcomes. However its role in states of disordered phosphate homeostasis and normal kidney function is as yet under characterised. AIMS: To investigate whether this biomarker of vascular calcification and adverse bone outcomes is detectable in patients with sarcoidosis...
2016: Sarcoidosis, Vasculitis, and Diffuse Lung Diseases: Official Journal of WASOG
https://www.readbyqxmd.com/read/27526425/-treatment-of-secondary-hyperparathyroidism-in-hemodialysed-patients-paricalcitol-with-or-without-cinacalcet
#13
Jacek Zawierucha, Jolanta Małyszko, Jacek Małyszko, Teresa Dryl-Rydzyńska, Tomasz Prystacki, Wojciech Marcinkowski
Secondary hyperparathyroidism (sHPT) is a common complication being a consequence of metabolic disorders associated with chronic kidney disease (CKD). Treatment of the sHPT should lead to calcium-phosphate management stabilization and parathyroid hormone levels reduction. The phosphate binders, synthetic vitamin D analogs and calcimimetics are used in sHPT treatment. In this paper we analyzed the results of three month paricalcitol treatment of 36 hemodialysis patients with sHPT (serum iPTH> 500 pg/ml). 11 patients have additionally received cinacalcet...
2016: Przegla̧d Lekarski
https://www.readbyqxmd.com/read/27525532/pth-1-34-for-the-primary-prevention-of-post-thyroidectomy-hypocalcemia-the-thypos-trial
#14
A Palermo, G Mangiameli, G Tabacco, F Longo, C Pedone, S I Briganti, D Maggi, F Vescini, A Naciu, A Lauria Pantano, N Napoli, S Angeletti, P Pozzilli, P Crucitti, S Manfrini
CONTEXT: There are no studies evaluating teriparatide for prevention of post-thyroidectomy hypocalcemia. OBJECTIVE: To evaluate whether teriparatide can prevent post-surgical hypocalcemia and shorten the hospitalization in subjects at high risk of hypocalcemia following thyroid surgery. DESIGN: Prospective Phase II Randomized Open Label Trial. SETTING: Surgical ward. PATIENTS: 26 subjects (6 males, 20 females) with iPTH<10 pg/ml, 4 hours after thyroidectomy...
August 15, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27504353/video-assisted-thoracoscopic-surgery-vats-for-excision-of-an-ectopic-anterior-mediastinal-intra-thymic-parathyroid-adenoma
#15
Dukhabandhu Naik, Kumaradoss Felix Jebasingh, Ramprasath, Gnanamuthu Birla Roy, Mazhuvanchary Jacob Paul
Ectopic anterior mediastinal parathyroid adenoma is a rare cause of Primary Hyperparathyroidism (PHPT). Imaging studies such as Technetium-99m ((99m)Tc) sestamibi parathyroid scan along with a Single Photon Emission Computerized Tomogram (SPECT), and contrast enhanced Computerized Tomogram (CT) of the neck and thorax can precisely localize the ectopic mediastinal parathyroid adenoma. We report a 40-year-old gentleman who presented with persistent pain in the right shoulder following trivial trauma. His biochemical investigations showed an elevated serum calcium of 11...
June 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27485841/-diabetic-kidney-disease-3rd-stage-laboratory-markers-of-mineral-bone-disorder
#16
Adriana Klimentová, Ivana Ságová, Dana Prídavková, Daniela Kantárová, Pavol Makovický, Jurina Sadloňová, Marián Mokáň
BACKGROUND: Diabetes mellitus is the most common cause of end stage kidney disease in the developed countries. Chronic kidney disease-mineral and bone disorder (CKD-MBD) develops with deteriorating of the renal functions. Diabetic patients on hemodialysis are characterized by low bone turnover, higher prevalence of severe and progressive vascular calcification with increased cardiovascular morbidity and mortality. The main factor which causes vascular calcification in patients with diabetic kidney disease (DKD) is poor glycemic control...
2016: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27471744/a-study-on-the-association-of-serum-fibroblast-growth-factor-23-with-various-indices-of-chronic-kidney-disease-patients-not-yet-on-dialysis
#17
Fatemeh Yaghoubi, Farrokhleghah Ahmadi, Mahboub Lesanpezeshki, Mitra Mahdavi Mazde
INTRODUCTION: Fibroblast growth factor-23 (FGF23) is found as a bone derived hormone which can influence the serum levels of parathormone, phosphorous and 1, 25-dihydroxyvitamin D. FGF23 may be a cardiovascular biomarker in patients with chronic kidney disease (CKD). While, FGF23 is inversely correlated with serum adiponectin level, thus it is possible that FGF23 is correlated to fat mass and related to dyslipidemia in CKD. OBJECTIVES: In this investigation, we studied the association of serum levels of FGF23 with serum lipid profile, body mass index (BMI), and various cardiovascular risk factors in patients with CKD...
2016: Journal of Renal Injury Prevention
https://www.readbyqxmd.com/read/27468225/pharmacogenetic-analysis-of-cinacalcet-response-in-secondary-hyperparathyroidism-patients
#18
Sohyun Jeong, In-Wha Kim, Kook-Hwan Oh, Nayoung Han, Kwon Wook Joo, Hyo Jin Kim, Jung Mi Oh
BACKGROUND: Secondary hyperparathyroidism (SHPT) is one of the major risk factors of morbidity and mortality in end-stage renal disease. Cinacalcet effectively controls SHPT without causing hypercalcemia and hyperphosphatemia. However, there is significant inter-individual response variance to cinacalcet treatment. Therefore, we aimed to evaluate the genetic effects related with parathyroid hormone regulation as factors for cinacalcet response variance. METHODS: Patients with a diagnosis of SHPT based on intact parathyroid hormone (iPTH) >300 pg/mL on dialysis were included in this study...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27466999/the-relation-of-calcium-phosphorus-metabolism-related-indexes-with-cardiac-damages
#19
L Wu, Y-H Bai, T Chen, L Zhang, Y-R Wang, H Zhu, Y-X Jiao, L Sun
OBJECTIVE: To observe and analyze the relation of calcium-phosphorus metabolism-related indexes with cardiac damage-related indexes in patients with chronic kidney disease (CKD) and to explore the roles of calcic and phosphor metabolization in cardiac damage and provide references for prevention of cardiovascular events in CKD patients. PATIENTS AND METHODS: A total of 98 inpatients, from Urology Department, who were not undergoing dialysis treatment and diagnosed with stages 3, 4, and 5 CKD according to K/DOQI guide were recruited...
July 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27438973/parathyroid-responsiveness-during-hypocalcemia-after-total-parathyroidectomy-and-autotransplantation-in-patients-with-renal-hyperparathyroidism
#20
Patricia Dreyer, Monique Nakayama Ohe, Livia Marcela Dos Santos, Ilda Sizue Kunii, Rodrigo Oliveira Santos, Aluizio Barbosa de Carvalho, Jose Gilberto Henriques Vieira
INTRODUCTION: Hyperparathyroidism is a frequent complication of chronic kidney disease (CKD). Total parathyroidectomy (PTX) with parathyroid tissue autotransplantation (AT) is a treatment option in those individuals that do not respond to clinical management. OBJECTIVE: To evaluate grafted parathyroid tissue response during induced hypocalcemia among CKD patients who underwent total PTX with AT. METHODS: Eighteen patients with renal hyperparathyroidism were submitted to total PTX with parathyroid AT selected by stereomicroscopy between April and October 2008...
June 2016: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
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