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iPTH, calcium

Mahin Ghorban-Sabbagh, Fatemeh Nazemian, Massih Naghibi, Mohammad-Taghi Shakeri, Saeedeh Ahmadi-Simab, Reza Javidi-Dasht-Bayaz
INTRODUCTION: For diagnosing of specific types of bone lesions in hemodialysis (HD) patients, it is necessary to conduct a bone biopsy as the gold standard method. However, it is an invasive procedure. While different markers have been suggested as alternative methods, none of them has been selected. The frequency of hip fractures is 80 fold in HD patients who have two-fold mortality as compared with general population. OBJECTIVES: Recently, serum leptin has been suggested as a bone density marker...
2016: Journal of Renal Injury Prevention
Stuart M Sprague, Paul W Crawford, Joel Z Melnick, Stephen A Strugnell, Shaukat Ali, Roberto Mangoo-Karim, Sungchun Lee, P Martin Petkovich, Charles W Bishop
BACKGROUND/AIMS: Vitamin D insufficiency and secondary hyperparathyroidism (SHPT) are associated with increased morbidity and mortality in chronic kidney disease (CKD) and are poorly addressed by current treatments. The present clinical studies evaluated extended-release (ER) calcifediol, a novel vitamin D prohormone repletion therapy designed to gradually correct low serum total 25-hydroxyvitamin D, improve SHPT control and minimize the induction of CYP24A1 and FGF23. METHODS: Two identical multicenter, randomized, double-blind, placebo-controlled studies enrolled subjects from 89 US sites...
September 28, 2016: American Journal of Nephrology
Samia Ait Faqih, Béfa Noto-Kadou-Kaza, Lalla Meryam Abouamrane, Naoufal Mtiou, Selma El Khaya, Mohamed Zamd, Ghislaine Medkouri, Mohamed Gharbi Bengahanem, Benyounes Ramdani
INTRODUCTION: Valvular calcifications are one of the major cardiovascular complications of hemodialysis because of its prevalence and its predictive indices of morbidity and mortality. There are many risk factors associated with these calcifications. Our study aims to evaluate both the prevalence of valvular calcifications in our patients on hemodialysis and their risk factors. METHODS: This was a single-center cross-sectional descriptive and analytical study of 111 adult patients who were on hemodialysis for more than 6 months at the hemodialysis center CHU Ibn Rushd, Casablanca and who underwent ETT during the year 2013...
2016: Pan African Medical Journal
Kazuomi Yamashita, Sonoo Mizuiri, Yoshiko Nishizawa, Shigemoto Kenichiro, Shigehiro Doi, Takao Masaki
BACKGROUND/AIM: Iron deficiency stimulates fibroblast growth factor 23 (FGF23) transcription. This study aimed to determine whether oral ferrous iron (Fe(2+) ) reduces the serum FGF23 levels of iron-deficient maintenance hemodialysis (MHD) patients in the same way as oral ferric iron (Fe(3+) ). METHODS: Thirty-one MHD patients with iron deficiency were enrolled in this prospective study. Patients who had taken iron supplements during the 8 weeks before the study were excluded...
August 25, 2016: Nephrology
Donal J Sexton, M W O'Reilly, P Geoghegan, S M Kinsella, P J Moran, A W O'Regan
BACKGROUND: Serum fibroblastic growth factor (FGF) 23 has recently been established as a major physiological regulator of phosphate homeostasis and may have a causal role in adverse cardiovascular and bone outcomes. However its role in states of disordered phosphate homeostasis and normal kidney function is as yet under characterised. AIMS: To investigate whether this biomarker of vascular calcification and adverse bone outcomes is detectable in patients with sarcoidosis...
2016: Sarcoidosis, Vasculitis, and Diffuse Lung Diseases: Official Journal of WASOG
Jacek Zawierucha, Jolanta Małyszko, Jacek Małyszko, Teresa Dryl-Rydzyńska, Tomasz Prystacki, Wojciech Marcinkowski
Secondary hyperparathyroidism (sHPT) is a common complication being a consequence of metabolic disorders associated with chronic kidney disease (CKD). Treatment of the sHPT should lead to calcium-phosphate management stabilization and parathyroid hormone levels reduction. The phosphate binders, synthetic vitamin D analogs and calcimimetics are used in sHPT treatment. In this paper we analyzed the results of three month paricalcitol treatment of 36 hemodialysis patients with sHPT (serum iPTH> 500 pg/ml). 11 patients have additionally received cinacalcet...
2016: Przegla̧d Lekarski
A Palermo, G Mangiameli, G Tabacco, F Longo, C Pedone, S I Briganti, D Maggi, F Vescini, A Naciu, A Lauria Pantano, N Napoli, S Angeletti, P Pozzilli, P Crucitti, S Manfrini
CONTEXT: There are no studies evaluating teriparatide for prevention of post-thyroidectomy hypocalcemia. OBJECTIVE: To evaluate whether teriparatide can prevent post-surgical hypocalcemia and shorten the hospitalization in subjects at high risk of hypocalcemia following thyroid surgery. DESIGN: Prospective Phase II Randomized Open Label Trial. SETTING: Surgical ward. PATIENTS: 26 subjects (6 males, 20 females) with iPTH<10 pg/ml, 4 hours after thyroidectomy...
August 15, 2016: Journal of Clinical Endocrinology and Metabolism
Dukhabandhu Naik, Kumaradoss Felix Jebasingh, Ramprasath, Gnanamuthu Birla Roy, Mazhuvanchary Jacob Paul
Ectopic anterior mediastinal parathyroid adenoma is a rare cause of Primary Hyperparathyroidism (PHPT). Imaging studies such as Technetium-99m ((99m)Tc) sestamibi parathyroid scan along with a Single Photon Emission Computerized Tomogram (SPECT), and contrast enhanced Computerized Tomogram (CT) of the neck and thorax can precisely localize the ectopic mediastinal parathyroid adenoma. We report a 40-year-old gentleman who presented with persistent pain in the right shoulder following trivial trauma. His biochemical investigations showed an elevated serum calcium of 11...
June 2016: Journal of Clinical and Diagnostic Research: JCDR
Adriana Klimentová, Ivana Ságová, Dana Prídavková, Daniela Kantárová, Pavol Makovický, Jurina Sadloňová, Marián Mokáň
BACKGROUND: Diabetes mellitus is the most common cause of end stage kidney disease in the developed countries. Chronic kidney disease-mineral and bone disorder (CKD-MBD) develops with deteriorating of the renal functions. Diabetic patients on hemodialysis are characterized by low bone turnover, higher prevalence of severe and progressive vascular calcification with increased cardiovascular morbidity and mortality. The main factor which causes vascular calcification in patients with diabetic kidney disease (DKD) is poor glycemic control...
2016: Vnitr̆ní Lékar̆ství
Fatemeh Yaghoubi, Farrokhleghah Ahmadi, Mahboub Lesanpezeshki, Mitra Mahdavi Mazde
INTRODUCTION: Fibroblast growth factor-23 (FGF23) is found as a bone derived hormone which can influence the serum levels of parathormone, phosphorous and 1, 25-dihydroxyvitamin D. FGF23 may be a cardiovascular biomarker in patients with chronic kidney disease (CKD). While, FGF23 is inversely correlated with serum adiponectin level, thus it is possible that FGF23 is correlated to fat mass and related to dyslipidemia in CKD. OBJECTIVES: In this investigation, we studied the association of serum levels of FGF23 with serum lipid profile, body mass index (BMI), and various cardiovascular risk factors in patients with CKD...
2016: Journal of Renal Injury Prevention
Sohyun Jeong, In-Wha Kim, Kook-Hwan Oh, Nayoung Han, Kwon Wook Joo, Hyo Jin Kim, Jung Mi Oh
BACKGROUND: Secondary hyperparathyroidism (SHPT) is one of the major risk factors of morbidity and mortality in end-stage renal disease. Cinacalcet effectively controls SHPT without causing hypercalcemia and hyperphosphatemia. However, there is significant inter-individual response variance to cinacalcet treatment. Therefore, we aimed to evaluate the genetic effects related with parathyroid hormone regulation as factors for cinacalcet response variance. METHODS: Patients with a diagnosis of SHPT based on intact parathyroid hormone (iPTH) >300 pg/mL on dialysis were included in this study...
2016: Drug Design, Development and Therapy
L Wu, Y-H Bai, T Chen, L Zhang, Y-R Wang, H Zhu, Y-X Jiao, L Sun
OBJECTIVE: To observe and analyze the relation of calcium-phosphorus metabolism-related indexes with cardiac damage-related indexes in patients with chronic kidney disease (CKD) and to explore the roles of calcic and phosphor metabolization in cardiac damage and provide references for prevention of cardiovascular events in CKD patients. PATIENTS AND METHODS: A total of 98 inpatients, from Urology Department, who were not undergoing dialysis treatment and diagnosed with stages 3, 4, and 5 CKD according to K/DOQI guide were recruited...
July 2016: European Review for Medical and Pharmacological Sciences
Patricia Dreyer, Monique Nakayama Ohe, Livia Marcela Dos Santos, Ilda Sizue Kunii, Rodrigo Oliveira Santos, Aluizio Barbosa de Carvalho, Jose Gilberto Henriques Vieira
INTRODUCTION: Hyperparathyroidism is a frequent complication of chronic kidney disease (CKD). Total parathyroidectomy (PTX) with parathyroid tissue autotransplantation (AT) is a treatment option in those individuals that do not respond to clinical management. OBJECTIVE: To evaluate grafted parathyroid tissue response during induced hypocalcemia among CKD patients who underwent total PTX with AT. METHODS: Eighteen patients with renal hyperparathyroidism were submitted to total PTX with parathyroid AT selected by stereomicroscopy between April and October 2008...
June 2016: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
Sanjay Vikrant, Anupam Parashar
BACKGROUND: Disordered mineral metabolism is common complications of chronic kidney disease (CKD). However, there are limited data on the pattern of these disturbances in Indian CKD population. MATERIALS AND METHODS: This was a prospective observational study of CKD-mineral and bone disorder (CKD-MBD) over a period of 3 years. The biochemical markers of CKD-MBD, namely, calcium, phosphorus, alkaline phosphatase, intact parathyroid hormone (iPTH), and 25-hydoxyvitamin Vitamin D3 (25OHD), were measured in newly diagnosed CKD Stage 3-5 and prevalent CKD Stage 5D adult patients...
July 2016: Indian Journal of Endocrinology and Metabolism
Lenar Yessayan, Carol Moore, Mei Lu, Jerry Yee
Introduction Noninvasive measures of bone activity include intact parathyroid hormone (iPTH) and bone-specific alkaline phosphatase (BSAP). Whether BSAP measurement alone or in combination with other biochemical data provides more reliable information about bone turnover than iPTH alone in African Americans on hemodialysis is unknown. Methods This cross-sectional study aimed to determine the optimal predictor and cutoff points for BSAP, iPTH, calcium and phosphorus in classifying bone biopsy findings. Forty-three African American hemodialysis patients were available for analysis...
June 27, 2016: Hemodialysis International
Zongli Diao, Xu Liu, Linxue Qian, Jing Liu, Sha Liu, Wenhu Liu
BACKGROUND: Microwave ablation (MWA) can be used to treat severe secondary hyperparathyroidism; however, its efficacy and the predictor of its efficacy are unclear. In this retrospective study we determined the predictor of efficacy of MWA and compared the efficacy of MWA and parathyroidectomy. MATERIALS AND METHODS: Patients with severe secondary hyperparathyroidism who had received MWA or parathyroidectomy were enrolled in the study. Participants with MWA were divided into response and no response groups based on efficacy...
September 2016: International Journal of Hyperthermia
Shi-yi Liu, Ning Zhang, Xiang-fei Meng, Shi-Wei Liu, Hong-wei Zhu, Lan-fang Li, Chun-ling Zhang
OBJECTIVE: To observe the effect of Bushen Huoxue Recipe (BHR) on inhibiting vascular calcification (VC) in chronic renal failure (CRF) rats by regulating BMP-2/Runx2/Osterix signal pathway, and to explore its possible mechanism. METHODS: Thirty SD rats were randomly divided into the normal group, the model group, and the BHR group, 10 in each group. Rats in the model group and the BHR group were administered with 250 mg/kg adenine suspension by gastroagavage and fed with 1...
March 2016: Chinese Journal of Integrated Traditional and Western Medicine
Hu Chen, De-Guang Wang, Liang Yuan, Gui-Ling Liu, Heng-Jie He, Juan Wang, Sen Zhang, Li Hao
BACKGROUND: The incidence of diabetic nephropathy (DN) increases year by year. However, clinical characteristics of DN patients on maintenance hemodialysis (MHD) were rarely reported in China. The purpose of this study was to examine the clinical characteristics of the DN patients on MHD in Anhui Province, Eastern China. METHODS: The clinical data of MHD patients in the hemodialysis centers of 26 hospitals in Anhui Province from January 1, 2014, to March 31, 2014, were examined...
June 5, 2016: Chinese Medical Journal
Albert Shieh, Rene F Chun, Christina Ma, Sten Witzel, Briana Meyer, Brandon Rafison, Leon Swinkels, Tonnie Huijs, Sam Pepkowitz, Brett Holmquist, Martin Hewison, John S Adams
CONTEXT: Controversy persists over: 1) how best to restore low serum 25-hydroxyvitamin D (25D) levels (vitamin D2 [D2] vs vitamin D3 [D3]); 2) how best to define vitamin D status (total [protein-bound + free] vs free 25D); and 3) how best to assess the bioactivity of free 25D. OBJECTIVE: To assess: 1) the effects of D2 vs D3 on serum total and free 25D; and 2) whether change in intact PTH (iPTH) is more strongly associated with change in total vs free 25D. DESIGN: Participants previously enrolled in a D2 vs D3 trial were matched for age, body mass index, and race/ethnicity...
August 2016: Journal of Clinical Endocrinology and Metabolism
Nazy Zarshenas, Maria Nacher, Ken W Loi, John O Jorgensen
BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) as a single-stage procedure has shown to be effective in achieving significant weight loss and resolving obesity-related co-morbidities. However, its nutrition consequences have not been extensively explored. This study aims to investigate weight loss and evolution of nutritional deficiencies in a group of patients 3 years post LSG. METHODS: Retrospective data of a group of patients, 3 years following LSG as a stand-alone procedure was collected...
May 5, 2016: Obesity Surgery
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