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https://www.readbyqxmd.com/read/29139062/tools-in-asthma-evaluation-and-management-when-and-how-to-use-them
#1
REVIEW
Anna Mulholland, Alana Ainsworth, Naveen Pillarisetti
The goals of asthma management are accurate diagnosis, prompt initiation of treatment and monitoring of disease progression to limit potential morbidity and mortality. While the diagnosis and management is largely based on history taking and clinical examination, there are an increasing number of tools available that could be used to aid diagnosis, define phenotypes, monitor progress and assess response to treatment. Tools such as the Asthma Predictive Index could help in making predictions about the possibility of asthma in childhood based on certain clinical parameters in pre-schoolers...
November 15, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29138580/s100a16-a-promising-candidate-as-a-prognostic-marker-for-platinum-based-adjuvant-chemotherapy-in-resected-lung-adenocarcinoma
#2
Ken Katono, Yuichi Sato, Makoto Kobayashi, Ryo Nagashio, Shinichiro Ryuge, Satoshi Igawa, Masaaki Ichinoe, Yoshiki Murakumo, Makoto Saegusa, Noriyuki Masuda
Purpose: Although cisplatin-based adjuvant chemotherapy improves the survival of patients with resected non-small-cell lung cancer, not all patients show a survival benefit, and some patients experience severe toxicity. Therefore, identifying biomarkers is important for selecting subgroups of patients who may show improved survival with platinum-based adjuvant chemotherapy. S100A16 is thought to play key roles during different steps of tumor progression. The aim of this study was to evaluate the use of S100A16 expression as a prognostic marker in patients with completely resected lung adenocarcinoma receiving platinum-based adjuvant chemotherapy...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29137415/ubiquitin-conjugating-enzyme-e2-l3-promoted-tumor-growth-of-nsclc-through-accelerating-p27kip1-ubiquitination-and-degradation
#3
Xingjie Ma, Junjie Zhao, Fan Yang, Haitao Liu, Weibo Qi
The molecular pathogenesis of human lung cancer has not been completely clarified. Here, we reported that UBE2L3, a member of the ubiquitin-conjugating enzymes (E2s), were overexpressed in non-small-cell lung cancer (NSCLC) tissues compared with the non-tumor tissues. High expression of UBE2L3 was correlated with advanced tumor stage and adverse outcomes. Knockdown of UBE2L3 inhibited NSCLC cell growth while ectopic expression of UBE2L3 promoted NSCLC cell growth in a cell cycle dependent manner. The results of subcutaneous tumor xenograft studies revealed that knockdown of UBE2L3 attenuated the in vivo tumor growth...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29137398/prognostic-significance-of-pd-l1-expression-and-tumor-infiltrating-lymphocyte-in-surgically-resectable-non-small-cell-lung-cancer
#4
Gen Lin, Xirong Fan, Weifeng Zhu, Cheng Huang, Wu Zhuang, Haipeng Xu, Xiandong Lin, Dan Hu, Yunjian Huang, Kan Jiang, Qian Miao, Chao Li
Programmed death ligand 1 (PD-L1) expression is a predictive biomarker of the success of PD-1/PD-L1 inhibitor therapy for patients with advanced non-small cell lung cancer (NSCLC) but its role as a prognostic marker for early stage resectable NSCLC remains unclear. Here, we studied PD-L1 expression and tumor infiltrating lymphocytes (TILs) in surgically resectable NSCLC and correlate the finding with clinicopathological features and patient outcomes. Total of 170 archival samples of resectable NSCLC were probed for PD-L1 expression using the clone 22C3 pharmDx kit...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29137177/comprehensive-profiling-of-lincrnas-in-lung-adenocarcinoma-of-never-smokers-reveals-their-roles-in-cancer-development-and-prognosis
#5
Ying Li, Zheng Wang, Asha Nair, Wei Song, Ping Yang, Xiaoju Zhang, Zhifu Sun
Long intergenic non-coding RNA (lincRNA) is a family of gene transcripts, the functions of which are largely unknown. Although cigarette smoking is the main cause for lung cancer, lung cancer in non-smokers is a separate entity and its underlying cause is little known. Growing evidence suggests lincRNAs play a significant role in cancer development and progression; however, such data is lacking for lung cancer in non-smokers, or those who have never smoked. This study conducted comprehensive profiling of lincRNAs from RNA sequencing (RNA-seq) data of non-smoker patients with lung adenocarcinoma...
November 13, 2017: Genes
https://www.readbyqxmd.com/read/29135534/the-multiple-faces-of-programmed-cell-death-ligand-1-expression-in-malignant-and-nonmalignant-cells
#6
Edwin R Parra, Pamela Villalobos, Jaime Rodriguez-Canales
Preliminary data suggest that tumor expression of programmed cell death ligand 1 (PD-L1) protein in human cancers, as determined by immunohistochemistry in formalin-fixed, paraffin-embedded tissue samples, may predict clinical response to anti-PD-1/PD-L1 therapy. PD-L1 is not a specific tumor marker and its expression is also observed in various nonmalignant cells, such as macrophages and lymphocytes, causing confusion in immunohistochemistry analysis when these inflammatory cells are overlapping with tumors cells...
November 13, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/29129073/stage-dependence-cell-origin-independence-and-prognostic-capacity-of-serum-glycan-fucosylation-%C3%AE-1-4-branching-%C3%AE-1-6-branching-and-%C3%AE-2-6-sialylation-in-cancer
#7
Shadi Ferdosi, Douglas S Rehder, Paul Maranian, Erik P Castle, Thai H Ho, Harvey I Pass, Daniel W Cramer, Karen S Anderson, Lei Fu, David E C Cole, Tao Le, Xifeng Wu, Chad R Borges
Glycans represent a promising but only marginally accessed source of cancer markers. We previously reported the development of a molecularly bottom-up approach to plasma/serum (P/S) glycomics based on glycan linkage analysis that captures features such as α2-6 sialylation, β1-6 branching, and core fucosylation as single analytical signals. Based on the behavior of P/S glycans established to date, we hypothesized that the alteration of P/S glycans observed in cancer would be independent of the tissue in which the tumor originated yet exhibit stage dependence that varied little between cancers classified on the basis of tumor origin...
November 12, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/29119259/rheumatoid-arthritis-associated-interstitial-lung-disease-current-concepts
#8
REVIEW
Yoel Brito, Marilyn K Glassberg, Dana P Ascherman
PURPOSE OF REVIEW: Among the many extra-articular complications of rheumatoid arthritis (RA), interstitial lung disease (ILD) contributes significantly to morbidity and mortality. Prevalence estimates for RA-ILD vary widely depending on the specific clinical, radiographic, and functional criteria used to establish the diagnosis. A key unresolved issue is whether early, subclinical forms of RA-ILD represent a precursor to end stage, fibrotic lung disease. Based on uncertainties surrounding the natural history of RA-ILD, incomplete understanding of underlying disease pathogenesis, and lack of controlled clinical trials, evidence-based therapeutic strategies remain largely undefined...
November 9, 2017: Current Rheumatology Reports
https://www.readbyqxmd.com/read/29118088/ido-immune-status-after-chemoradiation-may-predict-survival-in-lung-cancer-patients
#9
Weili Wang, Lei Huang, Jian-Yue Jin, Shruti Jolly, Yong Zang, Huanmei Wu, Li Yan, Wenhu Pi, Lang Li, Andrew L Mellor, Feng-Ming Spring Kong
Host immunity influences the impact of radiotherapy (RT) in cancer but mechanistic connections remain obscure. In this study, we investigated the relationship of indoleamine 2,3-dioxygenase (IDO) systemic activity on clinical outcomes in RT-treated non-small cell lung cancer (NSCLC). IDO-mediated production of kynurenine and the kynurenine:tryptophan ratio in patient blood serum were determined for stage III NSCLC patients at times before, during and after RT administration and then correlated to overall survival (OS), progression-free survival and disease progression rate in patients...
November 8, 2017: Cancer Research
https://www.readbyqxmd.com/read/29116025/mir-200c-suppresses-endometriosis-by-targeting-malat1-in-vitro-and-in-vivo
#10
Zongwen Liang, Yijie Chen, Yuan Zhao, Chaoyi Xu, Anqi Zhang, Qiong Zhang, Danhan Wang, Jing He, Wenfeng Hua, Ping Duan
BACKGROUND: Endometriosis is a common, benign, and estrogen-dependent disease characterized by pelvic pain and infertility. To date, the pathogenesis of endometriosis remains unclear. Recent studies have demonstrated that noncoding RNAs, including microRNAs and long noncoding RNAs, play important roles in the development of endometriosis. METHODS: Expression profiling of miRNAs in endometrial tissue was characterized using microarrays. The most differentially expressed miRNAs were confirmed using quantitative reverse transcriptase-polymerase chain reaction analysis in additional ectopic endometrial (n = 27) and normal endometrial (n = 12) tissues...
November 7, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29115396/cryptdin-2-predicts-intestinal-injury-during-heatstroke-in-mice
#11
Jingjing Ji, Zhengtao Gu, Hui Li, Lei Su, Zhifeng Liu
Intestinal injury-induced bacterial translocation and endotoxemia are important in the pathophysiological process of heatstroke. However, the underlying mechanism remains to be fully elucidated. Previous studies using 2D-gel electrophoresis found that defensin-related cryptdin-2 (Cry-2), an intestinal α-defensin, is upregulated in intestinal tissues during heatstroke in mice, and that treatment with ulinastatin, a multivalent enzyme inhibitor, reduced heat-induced acute lung injury. To investigate the association between Cry-2 and heat stress (HS)-induced intestinal injury and the probable protective role of ulinastatin, the present study examined the intestinal expression of Cry-2 via histopathologic analysis and reverse transcription-quantitative polymerase chain reaction analysis in mice with heatstroke...
November 1, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29114465/advance-in-predictive-and-prognostic-marker-assessments-in-lung-cancer
#12
Mari Mino-Kenudson
No abstract text is available yet for this article.
October 2017: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/29113350/brca1-and-stmn1-as-prognostic-markers-in-nsclcs-who-received-cisplatin-based-adjuvant-chemotherapy
#13
Mingxing Wang, Wanjun Li, Xuemei Xing, Dan Zhang, Jie Lei, Guoyin Li
Objective: In this study, we aimed to investigate the predictive effect of BRCA1, STMN1, MAPT and TUBB3 on the prognosis of patients with non-small cell lung cancer (NSCLC). Methods: Seventy NSCLC patients who received platinum-based chemotherapy from June 2009 to July 2011 were enrolled. The protein and mRNA levels of BRCA1, STMN1, MAPT and TUBB3 were determined. Survival time of the patients with NSCLC was also calculated. Results: High expression of BRCA1 or low expression of STMN1 was associated with a better prognosis in NSCLC patients (p<0...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29112011/role-of-various-metabolic-parameters-derived-from-baseline-18f-fdg-pet-ct-as-prognostic-markers-in-non-small-cell-lung-cancer-patients-undergoing-platinum-based-chemotherapy
#14
Akshima Sharma, Anant Mohan, Ashu Seith Bhalla, Mehar Chand Sharma, Sreenivas Vishnubhatla, Chandan J Das, Anil Kumar Pandey, Chandra Sekhar Bal, Chetan D Patel, Punit Sharma, Krishan Kant Agarwal, Rakesh Kumar
PURPOSE: The aim of this study was to prospectively evaluate the role of various quantitative and semiquantitative metabolic parameters derived from dynamic and static baseline F-FDG PET/CT in prediction of overall survival (OS) in non-small cell lung cancer (NSCLC) patients who were planned to undergo platinum-based chemotherapy. METHODS: Sixty patients (51 male and 9 female patients) with biopsy-proven NSCLC and mean age 59.55 ± 10.06 years who were planned to undergo platinum-based chemotherapy were enrolled in the study...
November 3, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29110960/the-clinical-role-of-fractional-exhaled-nitric-oxide-in-asthma-control
#15
Suguru Sato, Junpei Saito, Atsuro Fukuhara, Manabu Uematsu, Yasuhito Suzuki, Ryuichi Togawa, Yuki Sato, Takefumi Nikaido, Xintao Wang, Yoshinori Tanino, Mitsuru Munakata
BACKGROUND: The potential role and characteristics of fractional exhaled nitric oxide (FeNO) remain unclear in the treatment of asthma. OBJECTIVE: To explore the clinical role of FeNO in asthmatic treatment. METHODS: We evaluated whether the mean or change of FeNO levels in the treatment period is associated with other conventional control parameters and predicted some clinical outcomes of asthma. We retrospectively analyzed the mean and percentage change of FeNO levels in the first 5 measurements at our hospital...
October 27, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29109795/the-use-of-pet-imaging-for-prognostic-integrin-%C3%AE-2%C3%AE-1-phenotyping-to-detect-non-small-cell-lung-cancer-and-monitor-drug-resistance-responses
#16
Chiun-Wei Huang, Wen-Chuan Hsieh, Shih-Ting Hsu, Yi-Wen Lin, Yi-Hsiu Chung, Wen-Chi Chang, Han Chiu, Yun Han Lin, Chung-Pu Wu, Tzu-Chen Yen, Feng-Ting Huang
PURPOSE: Growing evidence has demonstrated that aberrant expression of integrin α2β1 might contribute to the invasion, metastasis and drug resistance of non-small cell lung cancer (NSCLC). Thus, the integrin α2β1 targeting (68)Ga-DOTA-A2B1 tracer was validated in NSCLC in contrast to accumulation of the clinically used (18)F-FDG PET tracer to see if (68)Ga-DOTA-A2B1-PET imaging can offer a valuable and critical diagnostic imaging criterion for the identification of phenotypes of aggressive lung cancer...
2017: Theranostics
https://www.readbyqxmd.com/read/29108919/egfr-immunohistochemistry-as-biomarker-for-antibody-based-therapy-of-squamous-nsclc-experience-from-the-first-ring-trial-of-the-german-quality-assurance-initiative-for-pathology-quip-%C3%A2
#17
Iver Petersen, Manfred Dietel, Wolf J Geilenkeuser, Masoud Mireskandari, Wilko Weichert, Katja Steiger, Andreas H Scheel, Reinhard Büttner, Peter Schirmacher, Arne Warth, Felix Lasitschka, Hans-Ulrich Schildhaus, Thomas Kirchner, Simone Reu, Hans Kreipe, Florian Länger, Markus Tiemann, Christoph Schulte, Korinna Jöhrens
BACKGROUND: EGFR and its downstream signaling pathway are important targets for cancer therapy. Recently, the monoclonal anti-EGFR antibody Necitumumab in combination with gemcitabine and cisplatin was approved (EMA/14106/2016) for first-line treatment of squamous non-small cell carcinoma (SqNSCLC). Eligibility was restricted to cases with positive EGFR expression. In this context, a ring trial of the Quality Assurance Initiative for Pathology (QuIP(®)) was launched to prepare the German pathology community for a reliable and reproducible, immunohistochemically based biomarker test...
September 28, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29105365/platelet-to-lymphocyte-ratio-predicts-the-prognosis-of-patients-with-non-small-cell-lung-cancer-treated-with-surgery-and-postoperative-adjuvant-chemotherapy
#18
Michihito Toda, Takuma Tsukioka, Nobuhiro Izumi, Hiroaki Komatsu, Satoshi Okada, Kantaro Hara, Hikaru Miyamoto, Ryuichi Ito, Toshihiko Shibata, Noritoshi Nishiyama
BACKGROUND: Markers of preoperative tumor immunity, such as platelet-to-lymphocyte ratio (PLR), have been reported to be prognostic factors for patients with various cancers. However, the relationship between PLR and the prognosis of non-small cell lung cancer (NSCLC) patients treated with surgery and adjuvant chemotherapy as a multidisciplinary treatment is unknown. METHODS: We enrolled 327 NSCLC patients treated surgically with or without adjuvant chemotherapy (78 and 249 patients, respectively) at our hospital from 2008 to 2012...
November 3, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/29097801/efhd2-promotes-epithelial-to-mesenchymal-transition-and-correlates-with-postsurgical-recurrence-of-stage-i-lung-adenocarcinoma
#19
Chi-Chen Fan, Wei-Chung Cheng, Yu-Chuen Huang, Yuh-Pyng Sher, Nia-Jhen Liou, Yu-Chuan Chien, Pei-Shan Lin, Pei-Syuan Lin, Chung-Hsuan Chen, Wei-Chao Chang
Surgery is the only curative treatment for early-stage non-small cell lung cancer (NSCLC) patients. However, approximately one-third of these patients develop recurrence, which remains the main cause of mortality in the postsurgical treatment of NSCLC. Many molecular markers have been proposed to predict recurrence of early-stage disease, but no marker has demonstrated sufficient reliability for clinical application. In the present study, the novel protein EF-hand domain-containing protein D2 (EFHD2) was identified as expressed in highly metastatic tumor cells...
November 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29093708/dynamics-of-heat-shock-protein-70-serum-levels-as-a-predictor-of-clinical-response-in-non-small-cell-lung-cancer-and-correlation-with-the-hypoxia-related-marker-osteopontin
#20
Christian Ostheimer, Sophie Gunther, Matthias Bache, Dirk Vordermark, Gabriele Multhoff
Hypoxia mediates resistance to radio(chemo)therapy (RT) by stimulating the synthesis of hypoxia-related genes, such as osteopontin (OPN) and stress proteins, including the major stress-inducible heat shock protein 70 (Hsp70). Apart from its intracellular localization, Hsp70 is also present on the plasma membrane of viable tumor cells that actively release it in lipid vesicles with biophysical characteristics of exosomes. Exosomal Hsp70 contributes to radioresistance while Hsp70 derived from dying tumor cells can serve as a stimulator of immune cells...
2017: Frontiers in Immunology
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