keyword
https://read.qxmd.com/read/37762856/do-glp-1-analogs-have-a-place-in-the-treatment-of-pcos-new-insights-and-promising-therapies
#1
REVIEW
Aleksandra Szczesnowicz, Anna Szeliga, Olga Niwczyk, Gregory Bala, Blazej Meczekalski
Polycystic ovary syndrome (PCOS) is the most prevalent endocrinopathy in women of reproductive age. This condition is characterized by hyperandrogenism and either oligo- or anovulation. PCOS patients often present comorbidities such as obesity, insulin resistance, impaired glucose metabolism, dyslipidemia, hypertension, metabolic syndrome, and an increased risk of diabetes. Given the profound implications of metabolic impairment in PCOS, the accurate diagnosis and management of these facets are imperative. The first-line approach to treatment involves lifestyle modifications, including dietary adjustments and exercise aimed at achieving weight loss, a strategy consistently emphasized across the literature...
September 12, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/37726223/ginsenoside-f4-alleviates-skeletal-muscle-insulin-resistance-by-regulating-ptp1b-in-type-ii-diabetes-mellitus
#2
JOURNAL ARTICLE
Yujie Zhao, Yao Liu, Jianjun Deng, Chenhui Zhu, Xiaoxuan Ma, Min Jiang, Daidi Fan
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease with increasing morbidity. Protein tyrosine phosphatase 1B (PTP1B) is a major negative regulator of the insulin signaling cascade and has attracted intensive investigation in the T2DM study. Ginseng is widely used to treat metabolic diseases, while the effects of ginsenoside F4 (F4) on T2DM have remained unknown. Here, we identify F4 as an inhibitor of skeletal muscle insulin resistance. The results showed that F4 significantly improved the hyperglycemic state of db/db mice, alleviated dyslipidemia, and promoted skeletal muscle glucose uptake...
September 19, 2023: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/37365840/mas-receptor-a-potential-strategy-in-the-management-of-ischemic-cardiovascular-diseases
#3
REVIEW
Ali Molaei, Emad Molaei, A Wallace Hayes, Gholamreza Karimi
MasR is a critical element in the RAS accessory pathway that protects the heart against myocardial infarction, ischemia-reperfusion injury, and pathological remodeling by counteracting the effects of AT1R. This receptor is mainly stimulated by Ang 1-7, which is a bioactive metabolite of the angiotensin produced by ACE2. MasR activation attenuates ischemia-related myocardial damage by facilitating vasorelaxation, improving cell metabolism, reducing inflammation and oxidative stress, inhibiting thrombosis, and stabilizing atherosclerotic plaque...
July 2023: Cell Cycle
https://read.qxmd.com/read/35885396/carob-a-sustainable-opportunity-for-metabolic-health
#4
REVIEW
Aristea Gioxari, Charalampia Amerikanou, Irini Nestoridi, Eleni Gourgari, Harris Pratsinis, Nick Kalogeropoulos, Nikolaos K Andrikopoulos, Andriana C Kaliora
Carob ( Ceratonia siliqua L.) is an evergreen tree that belongs to the Leguminosae family and grows in the arid and semi-arid regions of the Mediterranean basin. The carob tree is resistant to droughts and salinity, while its deep root systems allow CO2 to sink, mitigating global warming effects. Traditionally, carob has been used to produce animal feed, but for many years, it was excluded from the human diet. Nowadays, agricultural and industrial sectors exploit carob fruit, also referred to as carob pod, and its primary products (i...
July 20, 2022: Foods (Basel, Switzerland)
https://read.qxmd.com/read/35760415/d-pinitol-promotes-tau-dephosphorylation-through-a-cyclin-dependent-kinase-5-regulation-mechanism-a-new-potential-approach-for-tauopathies
#5
JOURNAL ARTICLE
Dina Medina-Vera, Juan Antonio Navarro, Patricia Rivera, Cristina Rosell-Valle, Alfonso Gutiérrez-Adán, Carlos Sanjuan, Antonio Jesús López-Gambero, Rubén Tovar, Juan Suárez, Francisco Javier Pavón, Elena Baixeras, Juan Decara, Fernando Rodríguez de Fonseca
BACKGROUND AND PURPOSE: Recent evidence links brain insulin resistance with neurodegenerative diseases, where hyperphosphorylated tau protein contributes to neuronal cell death. In the present study, we aimed to evaluate if d-pinitol inositol, which acts as an insulin sensitizer, affects the phosphorylation status of tau protein. EXPERIMENTAL APPROACH: We studied the pharmacological effect of d-pinitol on insulin signalling and tau phosphorylation in the hippocampus of Wistar and Zucker rats...
June 27, 2022: British Journal of Pharmacology
https://read.qxmd.com/read/34267647/network-modeling-sex-differences-in-brain-integrity-and-metabolic-health
#6
JOURNAL ARTICLE
Janelle T Foret, Maria Dekhtyar, James H Cole, Drew D Gourley, Marie Caillaud, Hirofumi Tanaka, Andreana P Haley
Hypothesis-driven studies have demonstrated that sex moderates many of the relationships between brain health and cardiometabolic disease, which impacts risk for later-life cognitive decline. In the present study, we sought to further our understanding of the associations between multiple markers of brain integrity and cardiovascular risk in a midlife sample of 266 individuals by using network analysis, a technique specifically designed to examine complex associations among multiple systems at once. Separate network models were constructed for male and female participants to investigate sex differences in the biomarkers of interest, selected based on evidence linking them with risk for late-life cognitive decline: all components of metabolic syndrome (obesity, hypertension, dyslipidemia, and hyperglycemia); neuroimaging-derived brain-predicted age minus chronological age; ratio of white matter hyperintensities to whole brain volume; seed-based resting state functional connectivity in the Default Mode Network, and ratios of N-acetyl aspartate, glutamate and myo-inositol to creatine, measured through proton magnetic resonance spectroscopy...
2021: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/34202683/inositols-depletion-and-resistance-principal-mechanisms-and-therapeutic-strategies
#7
REVIEW
Elisa Lepore, Rosa Lauretta, Marta Bianchini, Marilda Mormando, Cherubino Di Lorenzo, Vittorio Unfer
Inositols are natural molecules involved in several biochemical and metabolic functions in different organs and tissues. The term "inositols" refers to five natural stereoisomers, among which myo-Inositol (myo-Ins) is the most abundant one. Several mechanisms contribute to regulate cellular and tissue homeostasis of myo-Ins levels, including its endogenous synthesis and catabolism, transmembrane transport, intestinal adsorption and renal excretion. Alterations in these mechanisms can lead to a reduction of inositols levels, exposing patient to several pathological conditions, such as Polycystic Ovary Syndrome (PCOS), hypothyroidism, hormonal and metabolic imbalances, like weight gain, hyperinsulinemia, dyslipidemia, and metabolic syndrome...
June 24, 2021: International Journal of Molecular Sciences
https://read.qxmd.com/read/34063339/natural-molecules-in-the-management-of-polycystic-ovary-syndrome-pcos-an-analytical-review
#8
REVIEW
Matteo Iervolino, Elisa Lepore, Gianpiero Forte, Antonio Simone Laganà, Giovanni Buzzaccarini, Vittorio Unfer
Polycystic ovary syndrome (PCOS) is a heterogenous disorder characterized by chronic ovulation dysfunction and hyperandrogenism. It is considered the most common endocrinological disorder, affecting up to 25% of women of reproductive age, and associated with long-term metabolic abnormalities predisposing to cardiovascular risk, such as insulin resistance (IR), dyslipidemia, endothelial dysfunction, and systemic inflammation. PCOS is also characterized by elevated serum levels of luteinizing hormone (LH), causing a condition of hyperandrogenism and a consequent altered ratio between LH and the follicle stimulating hormone (FSH)...
May 15, 2021: Nutrients
https://read.qxmd.com/read/33463457/polycystic-ovary-syndrome-a-contemporary-clinical-approach
#9
REVIEW
Jelica Bjekić-Macut, Tamara Vukašin, Zelija Velija-Ašimi, Azra Bureković, Marija Zdravković, Zoran Andrić, Marija Branković, Slobodanka Crevar-Marinović, Tatjana Madić, Olivera Stanojlović, Danijela V Milutinović, Sarantis Livadas, George Mastorakos
Polycystic ovary syndrome (PCOS) is a frequent endocrine disease in women during the reproductive period. It is considered a complex metabolic disorder with long-term metabolic, as well as reproductive consequences. Main pathophysiological pathways are related to the increased androgen levels and insulin resistance. Nowadays, genetic origins of PCOS are acknowledged, with numerous genes involved in the pathogenesis of hyperandrogenemia, insulin resistance, inflammation, and disturbed folliculogenesis. Rotterdam diagnostic criteria are most widely accepted and four PCOS phenotypes have been recognized...
2021: Current Pharmaceutical Design
https://read.qxmd.com/read/33280430/a-review-of-the-role-of-inositols-in-conditions-of-insulin-dysregulation-and-in-uncomplicated-and-pathological-pregnancy
#10
REVIEW
Oliver C Watkins, Hannah E J Yong, Neha Sharma, Shiao-Yng Chan
Inositols, a group of 6-carbon polyols, are highly bioactive molecules derived from diet and endogenous synthesis. Inositols and their derivatives are involved in glucose and lipid metabolism and participate in insulin-signaling, with perturbations in inositol processing being associated with conditions involving insulin resistance, dysglycemia and dyslipidemia such as polycystic ovary syndrome and diabetes. Pregnancy is similarly characterized by substantial and complex changes in glycemic and lipidomic regulation as part of maternal adaptation and is also associated with physiological alterations in inositol processing...
2022: Critical Reviews in Food Science and Nutrition
https://read.qxmd.com/read/32434357/chinese-medicine-bazi-bushen-capsule-improves-lipid-metabolism-in-ovariectomized-female-apoe-mice
#11
JOURNAL ARTICLE
Dan Huang, Huawei Hu, Liping Chang, Shen Liu, Junqing Liang, Yanfei Song, Xindong Wang, Hui Zhang, Cong Wei, Yiling Wu
BACKGROUND: Dyslipidemia is one of the mechanisms of atherosclerosis (AS). Depletion of estrogen plays a key role in the pathogenesis of postmenopausal AS in women, and the blood lipid levels of women are closely related to endogenous estrogen levels. Phytoestrogens (PEs) exert estrogenic effects, including protection against AS, without the adverse effects of estrogen administration. Bazi Bushen capsule (BZBS) is a traditional Chinese medicine herbal compound prescription that has been shown to contain 11 unique PEs...
May 2020: Annals of Palliative Medicine
https://read.qxmd.com/read/31507325/endoplasmic-reticulum-stress-may-be-involved-in-insulin-resistance-and-lipid-metabolism-disorders-of-the-white-adipose-tissues-induced-by-high-fat-diet-containing-industrial-trans-fatty-acids
#12
JOURNAL ARTICLE
Wanqiu Zhu, Xin Niu, Mingxia Wang, Zhao Li, Hong-Kun Jiang, Chuntao Li, Samantha J Caton, Yinglong Bai
BACKGROUND: Consumption of industrially produced trans-fatty acids (iTFAs) can result in alteration to lipid profile and glucose metabolism. Moreover, a diet high in iTFAs could increase the risk of obesity, cardiovascular diseases (CVDs) and type 2 diabetes mellitus. Glucose and lipid metabolism are closely linked in white adipose tissue (WAT), yet the underlying mechanisms of the effect of iTFAs in WAT are poorly understood. MATERIALS AND METHODS: Parameters of glucose homeostasis, lipid profiles and markers of endoplasmic reticulum (ER) stress of WAT were measured in rats maintained on a high-fat diet containing margarine (HFD-M) (n=10) compared to controls maintained on standard chow (n=10) over 16 weeks...
2019: Diabetes, Metabolic Syndrome and Obesity
https://read.qxmd.com/read/30442673/efavirenz-and-efavirenz-like-compounds-activate-human-murine-and-macaque-hepatic-ire1%C3%AE-xbp1
#13
JOURNAL ARTICLE
Carley J S Heck, Allyson N Hamlin, Namandje N Bumpus
Efavirenz (EFV), a widely used antiretroviral drug, is associated with idiosyncratic hepatotoxicity and dyslipidemia. Here we demonstrate that EFV stimulates the activation in primary hepatocytes of key cell stress regulators: inositol requiring 1α (IRE1α) and X-box binding protein 1 (XBP1). Following EFV exposure, XBP1 splicing (indicating activation) was increased 35.7-fold in primary human hepatocytes. Paralleling this, XBP1 splicing and IRE1α phosphorylation (p-IRE1α, active IRE1α) were elevated 36...
November 15, 2018: Molecular Pharmacology
https://read.qxmd.com/read/30320914/protein-translation-associated-to-perk-arm-is-a-new-target-for-regulation-of-metainflammation-a-connection-with-hepatocyte-cholesterol
#14
JOURNAL ARTICLE
Octavio Galindo-Hernández, Iván Córdova-Guerrero, Laura Janeth Díaz-Rubio, Ángel Pulido-Capiz, José Fernando Díaz-Villanueva, César Yahel Castañeda-Sánchez, Nicolás Serafín-Higuera, Víctor García-González
Endoplasmic reticulum stress is a cellular phenomenon that has been associated with metabolic disorders, contributing to the development of obesity, fatty liver disease, and dyslipidemias. Under metabolic overload conditions, in cells with a high protein-secretory activity, such as hepatocytes and Langerhans β cells, the unfolded protein response (UPR) is critical in to maintain protein homeostasis (proteostasis). UPR integrated by a tripartite signaling system, through activating transcription factor 6, protein kinase R-like endoplasmic reticulum kinase (PERK), and inositol-requiring enzyme 1, regulates gene transcription and translation to resolve stress and conserve proteostasis...
March 2019: Journal of Cellular Biochemistry
https://read.qxmd.com/read/29689241/pharmacologic-inhibition-of-s1p-attenuates-atf6-expression-causes-er-stress-and-contributes-to-apoptotic-cell-death
#15
JOURNAL ARTICLE
Paul Lebeau, Jae Hyun Byun, Tamana Yousof, Richard C Austin
Mammalian cells express unique transcription factors embedded in the endoplasmic reticulum (ER) membrane, such as the sterol regulatory element-binding proteins (SREBPs), that promote de novo lipogenesis. Upon their release from the ER, the SREBPs require proteolytic activation in the Golgi by site-1-protease (S1P). As such, inhibition of S1P, using compounds such as PF-429242 (PF), reduces cholesterol synthesis and may represent a new strategy for the management of dyslipidemia. In addition to the SREBPs, the unfolded protein response (UPR) transducer, known as the activating transcription factor 6 (ATF6), is another ER membrane-bound transcription factor that requires S1P-mediated activation...
June 15, 2018: Toxicology and Applied Pharmacology
https://read.qxmd.com/read/26491824/polycystic-ovary-syndrome-pcos-and-hyperandrogenism-the-role-of-a-new-natural-association
#16
COMPARATIVE STUDY
G Morgante, V Cappelli, A Di Sabatino, M G Massaro, V De Leo
AIM: Polycystic ovary syndrome (PCOS) affects 5-10% of women of childbearing age and manifests itself through oligomenorrhea, anovulation, hirsutism, micro-polycystic ovaries. Insulin resistance is a characteristic of PCOS patients and is more pronounced in obese patients. Insulin resistance and consequent hyperinsulinemia are related to many aspects of the syndrome such as hyperandrogenism, reproductive disorders, acne and hirsutism. In the long-term it may increase the risk of cardiovascular disease and negatively affect lipid profile and blood pressure...
October 2015: Minerva Ginecologica
https://read.qxmd.com/read/26456051/sh2-domain-containing-inositol-5-phosphatase-ship2-inhibition-ameliorates-high-glucose-induced-de-novo-lipogenesis-and-vldl-production-through-regulating-ampk-mtor-srebp1-pathway-and-ros-production-in-hepg2-cells
#17
JOURNAL ARTICLE
Sattar Gorgani-Firuzjaee, Reza Meshkani
Hepatic de-novo lipogenesis and production of triglyceride rich very low density lipoprotein (VLDL) is increased in the state of insulin resistance, however, the role of a negative regulator of the insulin signaling pathway, the SH2 domain-containing inositol 5-phosphatase (SHIP2) in this process, remains unknown. In the present study, we studied the molecular mechanisms linking SHIP2 expression to metabolic dyslipidemia using overexpression or suppression of SHIP2 gene in HepG2 cells exposed to high glucose (33 mM)...
December 2015: Free Radical Biology & Medicine
https://read.qxmd.com/read/26188518/sh2-domain-containing-inositol-5-phosphatase-ship2-regulates-de-novo-lipogenesis-and-secretion-of-apob100-containing-lipoproteins-in-hepg2-cells
#18
JOURNAL ARTICLE
Sattar Gorgani-Firuzjaee, Shohreh Khatami, Khosrow Adeli, Reza Meshkani
Hepatic de-novo lipogenesis and production of triglyceride rich VLDL are regulated via the phosphoinositide 3-kinase cascade, however, the role of a negative regulator of this pathway, the SH2 domain-containing inositol 5-phosphatase (SHIP2) in this process, remains unknown. In the present study, we investigated the molecular link between SHIP2 expression and metabolic dyslipidemia using overexpression or suppression of SHIP2 gene in HepG2 cells. The results showed that overexpression of the wild type SHIP2 gene (SHIP2-WT) led to a higher total lipid content (28%) compared to control, whereas overexpression of the dominant negative SHIP2 gene (SHIP2-DN) reduced total lipid content in oleate treated cells by 40%...
September 4, 2015: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/24898153/updates-on-the-myo-inositol-plus-d-chiro-inositol-combined-therapy-in-polycystic-ovary-syndrome
#19
REVIEW
Vittorio Unfer, Giuseppina Porcaro
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders affecting women of reproductive age. It is characterized by chronic anovulation, hyperandrogenism, and insulin resistance. It is the main cause of infertility due to the menstrual dysfunction and metabolic disorders. Women with PCOS also have an increased cardiovascular risk because of dyslipidemia and insulin resistance. So far, we have a lot of information about the etiology of PCOS, and many steps forward have been made about the diagnosis of this syndrome, but there is still no certainty about the therapy...
September 2014: Expert Review of Clinical Pharmacology
https://read.qxmd.com/read/23512296/dyslipidemia-links-obesity-to-early-cerebral-neurochemical-alterations
#20
JOURNAL ARTICLE
Andreana P Haley, Mitzi M Gonzales, Takashi Tarumi, Hirofumi Tanaka
OBJECTIVE: To examine the role of hypertension, hyperglycemia, and dyslipidemia in potentially accounting for obesity-related brain vulnerability in the form of altered cerebral neurochemistry. DESIGN AND METHODS: Sixty-four adults, ages 40-60 years, underwent a health screen and proton magnetic resonance spectroscopy ((1) H MRS) of occipitoparietal gray matter to measure N-acetyl aspartate (NAA), choline (Cho), myo-inositol (mI), and glutamate (Glu) relative to creatine (Cr)...
October 2013: Obesity
keyword
keyword
74700
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.