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dyslipidemia and chromium

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https://www.readbyqxmd.com/read/25346863/chromium-therapy-for-insulin-resistance-associated-with-hiv-disease
#1
Seth A Stein, Margaret Mc Nurlan, Brett T Phillips, Catherine Messina, Dennis Mynarcik, Marie Gelato
OBJECTIVE: With the advent of highly active anti-retroviral therapy, HIV disease has become a chronic condition, but with a number of metabolic complications including insulin resistance and diabetes mellitus, dyslipidemia and hypertension and an increased incidence of atherosclerosis. The aim of the current study was to test the safety and efficacy of chromium picolinate for HIV- associated insulin resistance. MATERIALS/METHODS: The study was a randomized, double-blind, placebo-controlled trial with subjects receiving 500μg of chromium picolinate or placebo twice daily for two months...
September 7, 2013: Journal of AIDS & Clinical Research
https://www.readbyqxmd.com/read/24393559/preventive-effects-of-selenium-yeast-chromium-picolinate-zinc-sulfate-and-their-combination-on-oxidative-stress-inflammation-impaired-angiogenesis-and-atherogenesis-in-myocardial-infarction-in-rats
#2
Nouf M Al-Rasheed, Hala A Attia, Raessa A Mohamed, Nawal M Al-Rasheed, Maha A Al-Amin
PURPOSE: Accumulating evidences suggest a critical role of trace metal dyshemostasis in oxidative stress and cardiac dysfunction after myocardial infarction (MI). This study investigated the cardioprotective effects of selenium yeast (Se), chromium picolinate Cr(pic)3, zinc sulfate (Zn) and their combination on isoproterenol (ISO)-induced MI. METHODS: Rats were divided into six groups: normal control, ISO control, Se-pretreated (0.1 mg/kg), Cr(pic)3-pretreated (400 µg/kg), Zn-pretreated (30 mg/kg) and metal combination-pretreated groups...
2013: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
https://www.readbyqxmd.com/read/23207812/-preliminary-evaluation-of-the-antioxidant-trace-elements-in-an-algerian-patient-with-type-2-diabetes-special-role-of-manganese-and-chromium
#3
Hassiba Harani, Amel Otmane, Mohamed Makrelouf, Nacer Ouadahi, Arezki Abdi, Abdelkrim Berrah, Akila Zenati, Barkahoum Alamir, Elhadj Ahmed Koceir
In type 2 diabetes, the relationship between antioxidants and insuline-like trace elements is very complex during oxidative stress, being mediated by hyperglycemia, dyslipidemia and inflammation. We investigated the antioxidant status, particularly Mn and Cr on the diabetes metabolic control, and their interaction with the metabolic syndrome (MS) parameters. The study was undertaken on 278 Algerian diabetic subjects who were divided in 2 groups according to glycated hemoglobin (HbA(1c)) <7% or >7% value, attesting for a good or poor metabolic control of diabetes, respectively...
November 2012: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/22650796/anti-atherogenic-effect-of-chromium-picolinate-in-streptozotocin-induced-experimental-diabetes
#4
Bhuvaneshwari Sundaram, Kirti Singhal, Rajat Sandhir
BACKGROUND: Several studies have implicated changes in the levels of trace elements in diabetes. Chromium is one such element that seems to potentiate insulin action, thereby regulating carbohydrate and lipid metabolism. The aim of the present study was to evaluate the effect of chromium supplementation as chromium picolinate on the lipid profile of streptozotocin (STZ)-induced diabetic rats. METHODS: Rats were rendered diabetic by a single injection of STZ (50 mg/kg, i...
March 2013: Journal of Diabetes
https://www.readbyqxmd.com/read/22423897/molecular-mechanisms-of-chromium-in-alleviating-insulin-resistance
#5
REVIEW
Yinan Hua, Suzanne Clark, Jun Ren, Nair Sreejayan
Type 2 diabetes is often associated with obesity, dyslipidemia and cardiovascular anomalies and is a major health problem approaching global epidemic proportions. Insulin resistance, a prediabetic condition, precedes the onset of frank type 2 diabetes and offers potential avenues for early intervention to treat the disease. Although lifestyle modifications and exercise can reduce the incidence of diabetes, compliance has proved to be difficult, warranting pharmacological interventions. However, most of the currently available drugs that improve insulin sensitivity have adverse effects...
April 2012: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/21808863/influence-of-metal-alloy-and-the-profile-of-coronary-stents-in-patients-with-multivessel-coronary-disease
#6
RANDOMIZED CONTROLLED TRIAL
Luciano Maurício de Abreu Filho, Antonio Artur da Cruz Forte, Marcos Kiyoshi Sumita, Desidério Favarato, George Cesar Ximenes Meireles
BACKGROUND: In Brazil, despite the recommendations of the Brazilian Society of Hemodynamics and Interventional Cardiology, the National Health System has not yet approved the use of drug-eluting stents. In percutaneous coronary interventions performed in the public and part of the private health care system, bare metal stents are used as the only option. Therefore, new information on bare metal stents is of great importance. The primary endpoint was to evaluate the influence of the alloy and the profile of coronary stents on late loss and restenosis rates 6 months after implantation in patients with multivessel coronary disease...
2011: Clinics
https://www.readbyqxmd.com/read/21801978/the-impact-of-dietary-changes-and-dietary-supplements-on-lipid-profile
#7
REVIEW
Jingbo Huang, Jiri Frohlich, Andrew P Ignaszewski
With a growing number of dietary interventions that claim to improve lipid profile, it is important to ensure that these claims are evidence based. The objective of this study was to make recommendations for dietary regimens by analyzing their effectiveness and the level of evidence. We searched MEDLINE as well as the Cochrane Database of Systematic Reviews for nutritional studies. Meta-analyses and randomized controlled trials published in English and including data on the effect on blood lipid levels were used...
July 2011: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/21311039/evidence-that-chromium-modulates-cellular-cholesterol-homeostasis-and-abca1-functionality-impaired-by-hyperinsulinemia-brief-report
#8
Whitney Sealls, Brent A Penque, Jeffrey S Elmendorf
OBJECTIVE: Trivalent chromium (Cr3+) is an essential micronutrient. Findings since the 1950s suggest that Cr3+ might benefit cholesterol homeostasis. Here we present mechanistic evidence in support of this role of Cr3+. METHODS AND RESULTS: High-density lipoprotein cholesterol generation in 3T3-L1 adipocytes, which are rendered ineffective by the hyperinsulinemia that is known to accompany disorders of lipid metabolism, was corrected by Cr3+. Mechanistically, Cr3+ reversed hyperinsulinemia-induced cellular cholesterol accrual and associated defects in cholesterol transporter ATP-binding cassette transporter-A1 trafficking and apolipoprotein A1-mediated cholesterol efflux...
May 2011: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/21134603/chromium-d-phenylalanine-3-alleviates-high-fat-induced-insulin-resistance-and-lipid-abnormalities
#9
Machender Reddy Kandadi, M K Unnikrishnan, Ajaya Kumar Sankara Warrier, Min Du, Jun Ren, Nair Sreejayan
High-fat diet has been implicated as a major cause of insulin resistance and dyslipidemia. The objective of this study was to evaluate the impact of dietary-supplementation of chromium (D-phenylalanine)(3) [Cr(D-Phe)(3)] on glucose and insulin tolerance in high-fat diet fed mice. C57BL/6-mice were randomly assigned to orally receive vehicle or Cr(D-Phe)(3) (45 μg of elemental chromium/kg/day) for 8-weeks. High-fat-fed mice exhibited impaired whole-body-glucose and -insulin tolerance and elevated serum triglyceride levels compared to normal chow-fed mice...
January 2011: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/19337698/chromium-status-and-glucose-tolerance-in-saudi-men-with-and-without-coronary-artery-disease
#10
Eman M Alissa, Suhad M Bahjri, Waqar H Ahmed, Nabeel Al-Ama, Gordon A A Ferns
Chromium deficiency is associated with impaired glucose tolerance (IGT) and dyslipidemia. Hence, the objective of the current study was to investigate chromium status among Saudi men with and without established cardiovascular disease (CVD) and its relationship to glucose tolerance, lipid profile and other established CVD risk factors. We measured serum and urine chromium concentrations, fasted lipid profile, plasma glucose, and serum lipid peroxide in 130 Saudi men with an established history of myocardial infarction and 130 age-matched controls without established CVD...
December 2009: Biological Trace Element Research
https://www.readbyqxmd.com/read/18636317/nutrigenomic-basis-of-beneficial-effects-of-chromium-iii-on-obesity-and-diabetes
#11
REVIEW
Francis C Lau, Manashi Bagchi, Chandan K Sen, Debasis Bagchi
Insulin resistance has been shown to be the major contributing factor to the metabolic syndrome, which comprises a cluster of risk factors for metabolic aberrations such as obesity, dyslipidemia, hypertension, and hyperglycemia. Additionally, insulin resistance has been associated with the occurrence of cardiovascular disease and type 2 diabetes. Epidemiological studies indicate that obesity and diabetes have become alarmingly prevalent in recent years. Substantial evidence suggests that dietary interventions and regular exercise greatly improve body mass index and lipid profile as well as alleviate insulin resistance...
October 2008: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/17851234/plasma-mineral-content-in-type-2-diabetic-patients-and-their-association-with-the-metabolic-syndrome
#12
M V Aguilar, P Saavedra, F J Arrieta, C J Mateos, M J González, I Meseguer, M C Martínez-Para
BACKGROUND: Metabolic syndrome is a clinical disorder that is becoming more prevalent in Spain. The syndrome encompasses a set of metabolic disorders such as type-2 diabetes mellitus, hypertension, dyslipidemia, and obesity, which may be associated with variations in serum levels and poor delivery of certain mineral elements. METHODS: This study attempted to ascertain whether metabolic syndrome might be linked to alterations in serum levels of the mineral elements magnesium, copper, zinc, chromium, and nickel in a population of 92 diabetic subjects, some suffering from certain conditions associated with the metabolic syndrome, and 72 control subjects (Hospital Príncipe de Asturias, Alcalá de Henares, Spain)...
2007: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/17684468/combination-of-chromium-and-biotin-improves-coronary-risk-factors-in-hypercholesterolemic-type-2-diabetes-mellitus-a-placebo-controlled-double-blind-randomized-clinical-trial
#13
RANDOMIZED CONTROLLED TRIAL
Cesar Albarracin, Burcham Fuqua, Jeff Geohas, Vijaya Juturu, Manley R Finch, James R Komorowski
Dyslipidemia, often found in type 2 diabetes mellitus (T2DM) patients, plays an important role in the progression of cardiometabolic syndrome. Two essential nutrients, chromium and biotin, may maintain optimal glycemic control. The authors report here a randomized, double-blind placebo-controlled trial (N=348; chromium picolinate and biotin combination [CPB]: 226, placebo: 122; T2DM participants with hemoglobin A1c [HbA1c] >or=7%) evaluating the effects of CPB on lipid and lipoprotein levels. Participants were randomly assigned (2:1 ratio) to receive either CPB (600 microg chromium as chromium picolinate and 2 mg biotin) or a matching placebo once daily for 90 days...
2007: Journal of the Cardiometabolic Syndrome
https://www.readbyqxmd.com/read/17109600/clinical-studies-on-chromium-picolinate-supplementation-in-diabetes-mellitus-a-review
#14
REVIEW
C Leigh Broadhurst, Philip Domenico
Chromium (Cr) picolinate (CrPic) is a widely used nutritional supplement for optimal insulin function. A relationship among Cr status, diabetes, and associated pathologies has been established. Virtually all trials using CrPic supplementation for subjects with diabetes have demonstrated beneficial effects. Thirteen of 15 clinical studies (including 11 randomized, controlled studies) involving a total of 1,690 subjects (1,505 in CrPic group) reported significant improvement in at least one outcome of glycemic control...
December 2006: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/16545457/insulin-sensitizing-and-cholesterol-lowering-effects-of-chromium-d-phenylalanine-3
#15
Xiaoping Yang, Shi-Yan Li, Feng Dong, Jun Ren, Nair Sreejayan
Low-molecular weight organic chromium complexes are thought to play a key role in carbohydrate and lipid metabolism and therefore have been gaining popularity as nutritional supplement for patients with diabetes and concomitant lipid disorders. The aim of the present study was to evaluate the effects of a novel synthetic chromium (d-phenylalanine)(3) complex on insulin-sensitivity, plasma lipid-profile and oxidant stress in a mouse model of type II diabetes. Plasma glucose levels following intraperitoneal insulin-challenge (1U/kg) to obese ob/ob(+/+) mice treated with Cr(d-Phe)(3) (150 microg/kg/day for 6 weeks) were significantly lower compared to vehicle-control (control: 175...
July 2006: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/15733857/a-newly-synthetic-chromium-complex-chromium-phenylalanine-3-improves-insulin-responsiveness-and-reduces-whole-body-glucose-tolerance
#16
Xiaoping Yang, Kamalakannan Palanichamy, Allyn C Ontko, M N A Rao, Cindy X Fang, Jun Ren, Nair Sreejayan
Low-molecular-weight organic chromium complexes such as chromium picolinate are often used as dietary supplements to improve insulin sensitivity and to correct dyslipidemia. However, toxicity associated with such chromium compounds has compromised their therapeutic value. The aim of this study was to evaluate the impact of a newly synthesized complex of chromium with phenylalanine, Cr(pa)3 on insulin-signaling and glucose tolerance. Cr(pa)3 was synthesized by chelating chromium(III) with D-phenylalanine ligand in aqueous solution...
February 28, 2005: FEBS Letters
https://www.readbyqxmd.com/read/15544444/a-perspective-on-the-current-strategies-for-the-treatment-of-obesity
#17
REVIEW
Steven V Joyal
The prevalence in obesity has increased dramatically over the past 30 years, more than double in the United States alone. Obesity is associated with an increased risk for type 2 diabetes mellitus, dyslipidemia, hypertension, biliary disease, obstructive sleep apnea, and certain types of cancer. The pathophysiology of obesity is complex, involving behavioral, environmental, and genetic factors. Current treatment options include behavior modification and lifestyle changes which incorporate weight-reducing diets and physical activity, FDA approved long-term anti-obesity pharmacological agents sibutramine and orlistat, non-FDA approved over-the-counter (OTC) supplements and nutriceuticals, and, when appropriate, bariatric surgery...
October 2004: Current Drug Targets. CNS and Neurological Disorders
https://www.readbyqxmd.com/read/14577612/effects-of-niacin-bound-chromium-maitake-mushroom-fraction-sx-and-hydroxycitric-acid-on-the-metabolic-syndrome-in-aged-diabetic-zucker-fatty-rats
#18
Nadeem Talpur, Bobby W Echard, Taharat Yasmin, Debasis Bagchi, Harry G Preuss
Previous studies in our laboratories have demonstrated that niacin-bound chromium (NBC), Maitake mushroom and (-)-hydroxycitric acid (HCA-SX) can ameliorate hypertension, dyslipidemias and diabetes mellitus, and therefore may be useful in weight management. In the present study, we used aged, diabetic Zucker fatty rats (ZFR) (70-75 weeks) in order to determine whether NBC, fraction SX of Maitake mushroom (MSX) and 60% (-)-hydroxycitric acid (HCA-SX) from Garcinia cambogia, alone or in combination, can affect certain aspects of the metabolic syndrome...
October 2003: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/10767668/insulin-resistance-lifestyle-and-nutritional-interventions
#19
REVIEW
G S Kelly
Insulin resistance appears to be a common feature and a possible contributing factor to several frequent health problems, including type 2 diabetes mellitus, polycystic ovary disease, dyslipidemia, hypertension, cardiovascular disease, sleep apnea, certain hormone-sensitive cancers, and obesity. Modifiable factors thought to contribute to insulin resistance include diet, exercise, smoking, and stress. Lifestyle intervention to address these factors appears to be a critical component of any therapeutic approach...
April 2000: Alternative Medicine Review: a Journal of Clinical Therapeutic
https://www.readbyqxmd.com/read/8529496/effects-of-chromium-supplementation-on-fasting-insulin-levels-and-lipid-parameters-in-healthy-non-obese-young-subjects
#20
RANDOMIZED CONTROLLED TRIAL
B E Wilson, A Gondy
Trivalent chromium is an essential trace element for normal carbohydrate metabolism and insulin sensitivity. Because of this biological activity, chromium supplementation has been studied as a potential therapy of insulin resistant states and dyslipidemias, and has been promoted as a health aid to the general population. To determine if there is a risk of subclinical chromium deficiency in young, otherwise healthy adults, we evaluated the effect of chromium supplementation, versus placebo, on insulin levels and serum lipids in a double-blind, randomized trial in 26 young adults (mean age 36 years)...
June 1995: Diabetes Research and Clinical Practice
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