keyword
https://read.qxmd.com/read/38494929/erythema-multiforme-like-fixed-drug-eruption-during-azathioprine-and-hydroxychloroquine-treatment-for-systemic-lupus-erythematosus-mimicking-rowell-syndrome-a-rare-and-challenging-clinical-scenario
#1
JOURNAL ARTICLE
Nada Shaker, Omar P Sangueza, Nuha Shaker, Megan Arthur, Dinesh Pradhan
Background. Fixed drug eruption and Rowell syndrome stand as intriguing entities with overlapping clinical and pathological features. Case Presentation . A 32-year-old female patient presented with a tender and pruritic rash on the left upper chest for 3 days. Clinical examination revealed a flaring rash on the chest, under her left eye, tongue, and lips. The patient had a significant past medical history of systemic lupus erythematous with positive (ANA, Sm, dsDNA, ribosomalP, RNP) antibodies, hypocomplementemia, inflammatory arthritis, discoid lupus, leukopenia, thrombocytopenia, and immune thrombocytopenic purpura, and avascular necrosis affecting both hips and her right knee...
March 18, 2024: International Journal of Surgical Pathology
https://read.qxmd.com/read/38478947/squamous-cell-carcinoma-arising-in-chronic-inflammatory-dermatoses
#2
REVIEW
Drew Kuraitis, Andrea Murina
Squamous cell carcinoma (SCC) is a known sequela of chronic inflammatory conditions of the skin. Labial discoid lupus erythema-tosus (DLE), oral lichen planus (OLP), and lichen sclerosus have a relatively short lag time from dermatosis onset to manifestation of malignancy; cutaneous DLE, hypertrophic lichen planus, chronic wounds, hidradenitis suppurativa (HS), and necrobiosis lipoidica can be present for decades before an associated malignancy is observed. Vigilant monitoring is essential for orolabial DLE, chronic HS, and chronic wounds because malignancies in these settings are particularly aggressive and often fatal...
January 2024: Cutis; Cutaneous Medicine for the Practitioner
https://read.qxmd.com/read/38478669/linear-discoid-lupus-erythematous-simulating-en-coup-de-sabre-morphea-in-a-female-chronic-granulomatous-disease-carrier
#3
JOURNAL ARTICLE
Diem-Phuong Dao, Dev Ram Sahni, Richard D Sontheimer
Discoid lupus erythematosus (DLE), a subtype of chronic cutaneous lupus may be observed in a linear pattern. A 21-year-old woman with history of chronic granulomatous disease state presented to our clinic for a chronic six-year skin eruption on her left eyebrow, left cheek, and left forehead. A punch biopsy of involved left forehead skin was performed and revealed perivascular and periadnexal lymphohistiocytic infiltrate without features of morphea or panniculitis, confirming the histopathologic changes of cutaneous lupus erythematous...
December 15, 2023: Dermatology Online Journal
https://read.qxmd.com/read/38451400/screening-of-genes-associated-with-immune-infiltration-of-discoid-lupus-erythematosus-based-on-weighted-gene-co-expression-network-analysis
#4
JOURNAL ARTICLE
Yuru Han, Shuang Liu, Shuo Shi, Yongyong Shu, Changlian Lu, Xuefeng Gu
Discoid lupus erythematosus (DLE) is a disorder of the immune system commonly seen in women of childbearing age. The pathophysiology and aetiology are still poorly understood, and no cure is presently available. Therefore, there is an urgent need to explore the underlying molecular mechanisms, as well as search for new therapeutic targets. Gene expression data from skin biopsies samples of DLE patients and healthy controls were downloaded from the Gene Expression Omnibus database. The differentially expressed genes (DEGs) between DLE and healthy control samples were identified by differential expression analysis...
March 7, 2024: Biochemical Genetics
https://read.qxmd.com/read/38441309/oral-lesions-in-adult-and-juvenile-onset-systemic-lupus-erythematosus-patients-a-case-series-report
#5
JOURNAL ARTICLE
Firstine Kelsi Hartanto, Irna Sufiawati
Systemic lupus erythematosus (SLE) is an autoimmune disease with various oral manifestations, including ulceration, white keratotic plaques, oral discoid lupus erythematosus, oral lichen planus (OLP)-like lesions, non-specific erythema, purpura, petechiae, and cheilitis, which resemble lesions of other systemic diseases. Recognizing the oral manifestation of SLE is essential for comprehensive patient management. This study reports 4 cases of SLE with various oral lesions, underlying conditions and diagnostic methods...
2024: Dental and Medical Problems
https://read.qxmd.com/read/38433363/a-gyrate-pattern-of-discoid-lupus-erythematosus
#6
Subin Lim, Lillian Sidky, Erika Eliott, Gabriela Cobos
No abstract text is available yet for this article.
March 3, 2024: Journal of Dermatology
https://read.qxmd.com/read/38406630/case-report-cannabinoid-therapy-for-discoid-lupus-erythematosus-in-a-dog
#7
Maria Eduarda Schmitz da Silva, Bruna Christianetti, Erik Amazonas, Marcy Lancia Pereira
Discoid lupus erythematosus (DLE) is a common autoimmune skin disease in dogs. Conventional treatments, such as corticosteroids, can be effective but often have side effects. This case report presents a successful use of cannabinoid therapy (CT) in a dog with DLE resistant to conventional treatment. A 2-year-old mixed-breed dog with a history of DLE presented with worsening lesions despite treatment with corticosteroids and other medications. Liver enzymes levels were elevated, indicating corticosteroid-induced side effects...
2024: Frontiers in Veterinary Science
https://read.qxmd.com/read/38406023/painful-limb-ulcers-a-case-report-on-ulcerative-discoid-lupus-erythematosus
#8
Shreya N Gupta, Bhushan Madke, Shivani D Jangid, Drishti M Bhatt, Arshiya Khan
Lupus erythematosus is an autoimmune disorder with varied clinical features. Discoid Lupus Erythematosus (DLE) presents as erythematous, raised plaques. The patients might present with photosensitivity, arthralgia, and nail changes. However, dermoscopy, clinical features, and laboratory markers like high titers of Antinuclear antibodies (ANA) help in clenching the diagnosis. We report a patient in her mid-60s presented with non-healing ulcers oozing pus discharge associated with pain and joint stiffness...
January 2024: Curēus
https://read.qxmd.com/read/38389858/papulonodular-mucinosis-with-features-of-discoid-lupus-erythematosus
#9
Emma Hansen, Cory Pettit, Catherine G Chung, Abraham M Korman
No abstract text is available yet for this article.
March 2024: JAAD Case Reports
https://read.qxmd.com/read/38379874/an-impressive-case-of-rowell-syndrome-with-extensive-mucosal-involvement-successfully-treated-with-anifrolumab
#10
JOURNAL ARTICLE
Daniel R Antohi, Anitha Ramu, Tian Zhu, Shudan Wang, Michael Occidental, Bijal Amin, Benedict Wu, Jeanie Lee
No abstract text is available yet for this article.
March 2024: JAAD Case Reports
https://read.qxmd.com/read/38364410/dermoscopic-characteristics-of-cutaneous-lupus-erythematosus-according-to-subtype-lesion-location-lesion-duration-and-clasi-score
#11
JOURNAL ARTICLE
Yıldız Gürsel Ürün, Mustafa Ürün, Mehmet Şerif Danişman
INTRODUCTION: Dermoscopic findings are used to diagnose and evaluate disease activity in patients with cutaneous lupus erythematosus (CLE). OBJECTIVES: This study aimed to characterize the dermoscopic features of discoid LE (DLE) and LE tumidus (LET) by lesion duration and CLE Disease Area and Severity Index (CLASI) scores and to examine the dermoscopic findings of lesions in different locations in DLE patients. METHODS: Dermoscopic findings (follicular features, perifollicular surface, interfollicular features, and vessel pattern) were assessed and lesion duration (≤12 and >12 months) and CLASI scores (grouped as mild or moderate) were calculated...
January 1, 2024: Dermatology Practical & Conceptual
https://read.qxmd.com/read/38358820/lupus-dermal-fibroblasts-are-pro-inflammatory-and-exhibit-a-pro-fibrotic-phenotype-in-scarring-skin-disease
#12
JOURNAL ARTICLE
Suzanne K Shoffner-Beck, Lisa Abernathy-Close, Stephanie Lazar, Feiyang Ma, Mehrnaz Gharaee-Kermani, Amy Hurst, Craig Dobry, Deepika Pandian, Rachael Wasikowski, Amanda Victory, Kelly Arnold, Johann E Gudjonsson, Lam C Tsoi, J Michelle Kahlenberg
Fibroblasts are stromal cells known to regulate local immune responses important for wound healing and scar formation; however, the cellular mechanisms driving damage and scarring in cutaneous lupus erythematosus (CLE) patients remain poorly understood. Dermal fibroblasts in systemic lupus erythematosus (SLE) patients are abnormally exposed to cytokines, but the impact of inflammatory mediators on fibroblast responses in non-scarring versus scarring CLE subtypes is unclear. Here, we examined responses to cytokines in dermal fibroblasts from non-lesional skin of 22 SLE patients with CLE and 34 healthy controls...
February 15, 2024: JCI Insight
https://read.qxmd.com/read/38323569/squamous-cell-carcinoma-arising-from-discoid-lupus-erythematosus
#13
JOURNAL ARTICLE
Yin Yu, Lin Feng
No abstract text is available yet for this article.
February 7, 2024: Journal of Cutaneous Medicine and Surgery
https://read.qxmd.com/read/38321607/concentrated-growth-factor-therapy-as-cosmetic-treatment-in-discoid-lupus-erythematosus
#14
JOURNAL ARTICLE
Xiao-Shuang Yang, Ting-Ting Wang, Yu-Xin Ding, Yu-Hong Chen, Zhong-Fa Lv
Discoid lupus erythematosus (DLE) is a disfigurement disease. The atrophic scar and hair loss of this disease are followed by cosmetic defects and profoundly impact psychological health. Concentrated growth factor (CGF) has been widely adopted in medical cosmetology. Here we report a 36-year-old female systemic lupus erythematosus patient with a 5-year history of alopecia in DLE, who was recommended for CGF therapy and experienced hair regrowth. We suggest that CGF may be an effective cosmetic treatment for DLE...
February 6, 2024: Journal of Dermatology
https://read.qxmd.com/read/38306129/atypical-dyschromia-in-skin-of-color
#15
JOURNAL ARTICLE
Mohammed Moumen, Amy J McMichael
Dyschromia is a concern for many patients, especially persons of color. Postinflammatory hypopigmentation and depigmentation can affect all skin types; however, it is more apparent in those with darker skin. Some members of the dermatology community may not comprehensively understand the mechanisms of these reactions and the extent of the psychosocial effect they have on persons of color. Skin of color patients experiencing a decrease or loss of pigmentation are left with few treatment options, with no available evidence-based treatment established from a sufficient sample size...
February 1, 2024: Journal of Drugs in Dermatology: JDD
https://read.qxmd.com/read/38298760/interesting-mucocutaneous-manifestations-in-covid-19-infection-or-vaccination-confirmed-by-histopathology-a-case-series
#16
JOURNAL ARTICLE
Arash Pour Mohammad, Elahe Noroozi, Milad Gholizadeh Mesgarha, Nasrin Shayanfar, Azadeh Goodarzi
INTRODUCTION: Mucocutaneous complications or adverse events due to SARS-CoV-2 infection or vaccination have been well delineated in the literature, respectively. Most eruptions are considered mild and self-limiting; however, for the atypical cases with a tentative clinical diagnosis, performing a biopsy and histopathological assessment is pivotal to confirm the diagnosis and subsequently prescribe a more tailored treatment. Despite the diverse reporting of such incidents globally, most studies restrict the rate of biopsied cases to less than 15%...
2024: Case Reports in Dermatology
https://read.qxmd.com/read/38291478/anti-toxoplasma-gondii-antibodies-as-a-risk-factor-for-the-prevalence-and-severity-of-systemic-lupus-erythematosus
#17
JOURNAL ARTICLE
Zhongzhen Li, Zhiwei Lei, Wanying Yang, Chunxia Jing, Xiaolin Sun, Guang Yang, Xiaozhen Zhao, Mingjiao Zhang, Miaomiao Xu, Yuanjia Tang, Qingwen Wang, Jing Zhao, Zixing Zhou, Zihao Wen, Xiaojing Chen, Qinglin Peng, Guochun Wang, Pingjing Zhang, Erwei Sun, Nan Shen, Weiguo Xu, Zhanguo Li, Hengwen Yang, Zhinan Yin
BACKGROUND: Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease characterized by the presence of numerous autoantibodies. The interaction of infectious agents (viruses, bacteria and parasites) and a genetically susceptible host may be a key mechanism for SLE. Toxoplasma gondii is a widespread intracellular parasite that has been implicated in the pathogenesis of autoimmune diseases. However, the relationship between T. gondii infection and the increased risk of SLE in Chinese populations remains unclear...
January 30, 2024: Parasites & Vectors
https://read.qxmd.com/read/38226118/an-atypical-initial-manifestation-of-systemic-lupus-erythematosus-lupus-enteritis-accompanied-by-intestinal-pseudo-obstruction-and-bilateral-hydronephroureter
#18
Faiza Naeem, Mishkawt U Noor, Shabnam Batool, Saira E Anwer Khan, Muhammad Akmal
Systemic lupus erythematosus (SLE) is a systemic, autoimmune, multisystem disease. Lupus enteritis accompanied by intestinal pseudo-obstruction (IPO) is a serious and rare initial manifestation that can lead to high mortality and morbidity in case of delay in diagnosis and treatment. Here, we present a very complicated case of a 36-year-old female Pakistani patient with lupus enteritis accompanied by IPO and bilateral hydronephroureter. The patient had a three-month history of fever, weight loss, recurrent diarrhea, vomiting, alopecia, and photosensitivity...
December 2023: Curēus
https://read.qxmd.com/read/38191786/optical-coherence-tomography-promising-imaging-technique-for-the-diagnosis-of-oral-mucosal-diseases
#19
REVIEW
Xu-Ya Chen, Gang Zhou, Jing Zhang
OBJECTIVE: This review aims to summarize the latest application of optical coherence tomography (OCT) in oral mucosal diseases, promoting an accurate and earlier diagnosis of such disorders, which are difficult to be differentiated. SUBJECTIVE AND METHODS: References on the application of OCT in oral mucosal diseases were mainly obtained from PubMed, Embase, Web of Science and Scopus databases, using the keywords: "optical coherence tomography and 'oral mucosa/oral cancers/oral potentially malignant diseases/oral lichen planus/oral leukoplakia/oral erythroplakia/discoid lupus erythematosus/oral autoimmune bullous diseases/oral ulcers/erythema multiforme/oral mucositis'"...
January 8, 2024: Oral Diseases
https://read.qxmd.com/read/38179435/distal-periarterial-sympathectomy-surgery-for-chronic-digital-ischemia-a-systematic-review-of-the-literature
#20
JOURNAL ARTICLE
Nicholas Cereceda-Monteoliva, Yat Wing Smart, Elizabeth Ojelade, Gavin Schaller, Onur Berber
OBJECTIVE: This study assesses the efficacy of distal periarterial sympathectomy in treating chronic digital ischemia by evaluating clinical outcomes of surgery. METHODS: A systematic literature review of distal sympathectomy for chronic digital ischemia was conducted. Data extracted included study design, patient statistics, aetiology, follow-up duration, sympathectomy level, and surgical outcomes. RESULTS: 21 studies were analysed, containing a total of 337 patients, 324 hands, and 398 digits...
April 2024: Journal of Orthopaedics
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