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Discoid lupus

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https://www.readbyqxmd.com/read/29214102/white-rosettes-in-discoid-lupus-erythematosus-a-new-dermoscopic-observation
#1
Balachandra S Ankad, Swapnil D Shah, Keshavmurthy A Adya
White rosettes are shiny white structures seen as four oval-shaped points that come together in the center. They resemble four-leaf clover [1]. Earlier it was thought they were specific for actinic keratosis and squamous cell carcinoma, but they are noted in many other conditions [2]. With polarized light dermoscopy, it is evident that rosettes are seen only and they are due to the optical effect between polarized light and follicular structures [3]. Here, authors describe cases of discoid lupus erythematosus (DLE) demonstrating rosettes under polarized dermoscopy...
October 2017: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/29177151/blue-white-veil-as-novel-dermatoscopic-feature-in-discoid-lupus-erythematosus-in-2-african-american-patients
#2
Jessica Cervantes, Farhaan Hafeez, Mariya Miteva
Dermoscopic features of discoid lupus erythematosus (DLE) depend on the stage of the lesions: active lesions include yellow-brown dots and red dots, whereas longstanding inactive lesions show absence of follicular openings, cicatricial milky red or white patches, structureless white and brown areas, and thick arborizing vessels. Loss of pinpoint white dots, blue-gray dots in a speckled pattern, and a peripheral pigmented network have been described on dermoscopy of DLE in dark skin. We report a blue-white veil as a novel dermoscopic feature in 2 cases of biopsy-proven DLE in African-American patients...
October 2017: Skin Appendage Disorders
https://www.readbyqxmd.com/read/29166518/yellow-dots-in-trichoscopy-relevance-clinical-significance-and-peculiarities
#3
Caren Dos Santos Lima, Luciana Rodino Lemes, Daniel Fernandes Melo
Yellow dots are follicular ostium filled with keratin and/or sebum. Initially, they were exclusively associated with alopecia areata. Currently they have also been described in androgenetic alopecia, chronic cutaneous (discoid) lupus erythematosus, and dissecting cellulitis. Due to the growing importance of trichoscopy and its findings in the evaluation of the scalp, this article describes the main diseases in which yellow dots are a common trichoscopic finding, highlighting its characteristics in each dermatosis...
September 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29122902/a-rare-case-of-unilateral-discoid-lupus-erythematosus-mimicking-lupus-vulgaris
#4
Parul Verma, Sucheta Pathania, Asha Kubba
Discoidlupus erythematosus (DLE) is a chronic type of cutaneous lupus erythematosus which can present in various morphologies, and the diagnosis can be rather confounding. Prompt evaluation and treatment is necessary to prevent disfigurement and systemic involvement associated with DLE. The following case presented a diagnostic dilemma as the lesion mimicked lupus vulgaris.
November 8, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29115062/monogenic-interferonopathies-phenotypic-and-genotypic-findings-of-candle-syndrome-and-its-overlap-with-c1q-deficient-sle
#5
Sulaiman M Al-Mayouf, Alhanouf AlSaleem, Nora AlMutairi, Abdullah AlSonbul, Tariq Alzaid, Anas M Alazami, Hamoud Al-Mousa
OBJECTIVE: To report the clinical and genetic features of the first cases of chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) syndrome in an Arab population and to compare them with patients of C1q deficient systemic lupus erythematosus (SLE). MATERIALS AND METHODS: This is a retrospective case series of patients with CANDLE syndrome and C1q deficient SLE seen at a single tertiary hospital. Medical records were reviewed for demographic data, clinical and laboratory features, histopathology and imaging findings, and response to therapeutic intervention...
November 8, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29102423/rare-cause-of-periorbital-and-eyelids-lesions-discoid-lupus-erythematosus-misdiagnosed-as-allergy
#6
Anzelika Chomiciene, Ruta Stankeviciute, Laura Malinauskiene, Jurate Grigaitiene, Audra Blaziene
No abstract text is available yet for this article.
October 25, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29068087/dramatic-effect-of-hydroxychloroquine-on-lupus-alopecia
#7
Shohei Igari, Toshiyuki Yamamoto
Lupus alopecia is usually difficult to treat. We report a case of a 40-year-old woman with Sjögren's syndrome and atopic dermatitis who presented with discoid lupus erythematosus on the forearms and lupus erythematosus profundus with alopecia involving the scalp. A biopsy specimen taken from the discoid lupus erythematosus lesion on the forearm further exhibited a xanthomatous reaction, which however was not detected in another specimen from the lupus erythematosus profundus on the scalp. Treatment with oral hydroxychloroquine showed dramatic effects and complete hair regrowth was obtained 3 months later...
October 25, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/29050884/initial-digital-vasculitis-in-a-large-multicenter-cohort-of-childhood-onset-systemic-lupus-erythematosus
#8
Ana Paula Sakamoto, Clovis Artur Silva, Marco Felipe Castro da Silva, Anandreia Simões Lopes, Gleice Clemente Souza Russo, Adriana Maluf Elias Sallum, Katia Kozu, Eloisa Bonfá, Claudia Saad-Magalhães, Rosa Maria Rodrigues Pereira, Claudio Arnaldo Len, Maria Teresa Terreri
OBJECTIVES: To assess clinical digital vasculitis (DV) as an initial manifestation of childhood-onset systemic lupus erythematosus (cSLE) within a large population. METHODS: Multicenter cross-sectional study including 852 cSLE patients (ACR criteria) followed in ten Pediatric Rheumatology centers in São Paulo State, Brazil. RESULTS: DV was observed in 25/852 (3%) cSLE patients. Periungual hemorrhage was diagnosed in 12 (48%), periungual infarction in 7 (28%), tip finger ulceration in 4 (16%), painful nodules in 1 (4%) and gangrene in 1 (4%)...
October 16, 2017: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/29038195/discoid-lupus-erythematosus-when-a-superficial-injury-is-a-red-herring-of-underlying-disease
#9
Emily Senderey, Shamik Patel
No abstract text is available yet for this article.
October 15, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28967499/multiple-primary-squamous-cell-carcinomas-of-the-lower-lip-and-tongue-arising-in-discoid-lupus-erythematosus-a-case-report
#10
Ioanna-Eirini Arvanitidou, Nikolaos G Nikitakis, Maria Georgaki, Nick Papadogeorgakis, Athanasios Tzioufas, Alexandra Sklavounou
Squamous cell carcinoma (SCC) developing in lesions of discoid lupus erythematosus (DLE) is rare, most frequently arising on sun-exposed skin and very rarely affecting the lips. A review of the English language literature revealed only 21 published cases of labial SCC in patients with DLE. Here, an unusual case of a patient with DLE who developed 3 primary SCCs of the oral and perioral region is presented. A 40-year-old female with a 24-year history of DLE with peri- and intraoral involvement initially developed SCC of the vermillion border of the right lower lip; the lesion was surgically removed and did not recur within 6 months...
August 30, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28966534/incidental-focal-acantholytic-dyskeratosis-in-a-patient-with-discoid-lupus-erythematosus-a-possible-role-for-spca1-in-the-pathogenesis-of-the-disease
#11
Hyeong-Rae Kim, Seul-Ki Lim, Hae-Eul Lee, Myung Im, Young Lee, Young-Joon Seo, Jeung-Hoon Lee
No abstract text is available yet for this article.
October 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28941498/not-just-skin-deep-systemic-disease-involvement-in-patients-with-cutaneous%C3%A2-lupus
#12
REVIEW
Jack C O'Brien, Benjamin F Chong
Cutaneous lupus erythematosus, specifically discoid lupus erythematosus, disproportionately affects those with skin of color and may result in greater dyspigmentation and scarring in darker skin types. In this article, we review investigations relevant to cutaneous lupus patients with skin of color at University of Texas Southwestern Medical Center, associations and risk of progression to systemic lupus, and recommendations for monitoring for systemic disease spread. Between 5% and 25% of patients with cutaneous lupus can develop systemic lupus...
October 2017: Journal of Investigative Dermatology. Symposium Proceedings
https://www.readbyqxmd.com/read/28932062/primary-idiopathic-pseudopelade-of-brocq-in-a-young-child
#13
Pragya Ashok Nair, Rochit Singhal, Kira Pariath
Pseudopelade of Brocq (PPB) is a rare, chronic, slowly progressive cicatricial alopecia that generally affects middle-aged women. Vertex and parietal scalp are commonly involved. It can be primary or secondary to end stage of other scarring alopecia such as lichen planopilaris and discoid lupus erythematosus. It is diagnosed by exclusion both clinically and trichoscopy. There is no standard treatment for PPB. We hereby report a case of rapidly progressing primary idiopathic pseudopelade of Brocq in a young female child confirmed by trichoscopy and histopathology...
July 2017: International Journal of Trichology
https://www.readbyqxmd.com/read/28918619/discoid-lupus-erythematosus-presenting-as-upper-eyelid-edema-and-erythema
#14
Abbas Darjani, Rana Rafiei, Alireza Mesbah, Razieh Golmohammadi, Behnam Rafiee, Mehriar Movaseghi
Discoid Lupus Erythematosus (DLE) is an autoimmune disorder that usually occurs on sun exposed areas of head and neck. Infrequently it could be presented by palpebral involvement and rarely unilateral upper eye lid edema and erythema have been reported as the sole manifestation of DLE. We describe a 38-year-old woman with chronic left upper eye lid edema and erythema from one year ago which was induced by steroid injection for left eyebrow alopecia. Histopathologic and direct immunofluorescent studies were made on palpebral skin tissue and confirmed DLE diagnosis...
July 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28914954/resident-rounds-part-iii-case-report-metastatic-cutaneous-squamous-cell-carcinoma-in-an-african-american-female
#15
Jennifer N Harb, Alexandra L Owens, Kathryn Mooneyham Potter, Michael Montuno, Reordan O De Jesus, Sailesh Konda
Cutaneous squamous cell carcinoma (cSCC) is the most common skin cancer diagnosed in African Americans.<sup>1</sup> Twenty to forty percent of cSCCs reported in African Americans are related to chronic scarring processes or areas of in ammation.<sup>2</sup> Risk factors for developing cSCCs in patients of color include chronic scars resulting from burns, skin ulcers, and radiation sites; and chronic inflammatory diseases such as discoid lupus and hidradenitis suppuritiva.<sup>1</sup> Although skin cancer only accounts for 1% to 2% of cancers diagnosed within African Americans, it is associated with increased morbidity and mortality in this population...
January 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28816744/eruptive-keratoacanthoma-like-discoid-lupus-erythematosus
#16
Corey Georgesen, Cynthia Magro
Hypertrophic discoid lupus erythematosus can resemble keratoacanthoma histomorphologically. We describe a unique case of eruptive keratoacanthomatous scaly papules in a 56-year-old woman with discoid lupus erythematosus. We review the literature and conclude by discussing important histologic features and useful immunostains to consider when attempting to discern the underlying identity and pathogenicity of such lesions.
August 9, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28816743/elastic-staining-in-differentiating-between-follicular-streamers-and-follicular-scars-in-horizontal-scalp-biopsy-sections
#17
Timothy Tan, Joan Guitart, Pedram Gerami, Pedram Yazdan
BACKGROUND: Accurate identification of follicular streamers versus follicular scars on horizontal scalp biopsy sections is important to differentiate between cicatricial and noncicatricial alopecias. However, distinguishing between them can be difficult especially in nonoptimal specimens. The utility of elastic Verhoeff-Van Gieson (EVG) stain in cicatricial alopecias has been described on vertical sections, but its evaluation on horizontal sections has not been performed. METHODS: Sixty-four cicatricial alopecias (25 lichen planopilaris, 29 central centrifugal cicatricial alopecias, and 10 discoid lupus erythematosus) and 53 noncicatricial alopecias (34 androgenic alopecia, 8 telogen effluvium, and 11 alopecia areata) were identified, and EVG staining was performed on horizontal sections...
August 9, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28811115/recurrence-of-cutaneous-coccidioidomycosis-6-years-after-valley-fever-a-case-presentation-and-literature-review
#18
Rana Shahab, Nasir K Amra, Rola Rabah, Justin Saunar, Joan Soriano, Jaffar A Al-Tawfiq
Coccidioidomycosis is usually acquired by inhalation of spores of Coccidioides immitis and C. posadasii. The disease ranges from a self-limited acute pneumonia (Valley Fever) to a disseminated disease. We present a 44-year-old healthy male who had patchy hair loss of several months duration resembling discoid lupus. He developed a firm non-scaly red plaque on the right forehead. Initial biopsy showed spongiotic dermatitis, and he was treated with systemic steroids. He then developed forehead and periorbital cellulitis and was treated with systemic antibiotics...
July 8, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28770711/chinese-lupus-treatment-and-research-group-cstar-registry-x-family-history-in-relation-to-lupus-clinical-and-immunological-manifestations
#19
Xiaomei Leng, Mengtao Li, Xiangpei Li, Xiao Zhang, Shengyun Liu, Lijun Wu, Li Ma, Liqi Bi, Xiaoxia Zuo, Lingyun Sun, Cibo Huang, Jiuliang Zhao, Yan Zhao, Xiaofeng Zeng
OBJECTIVES: This study aimed to examine the associations between family history and clinical manifestations and immunologic characteristics of lupus in China. METHODS: Based on their family history, lupus patients from the Chinese lupus treatment and research group (CSTAR) registry were categorised: familial lupus (FL), family history of other rheumatic disorders (RD), and sporadic lupus (SL). Demographic data, clinical manifestations, and laboratory data were compared among these three groups...
July 7, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28762061/direct-antiglobulin-coombs-test-in-systemic-lupus-erythematosus-patients
#20
Thelma Skare, Leandro Picelli, Thiago Alberto G Dos Santos, Renato Nisihara
The objective of the study is to study the positivity of Coombs test or direct antiglobulin test (DAT) in systemic lupus erythematosus (SLE) patients and its relationship with disease's clinical and serological profile. Retrospective study of 373 SLE patients seen at single Rheumatology Unit. Epidemiological data (age, gender, age at disease onset, auto declared ethnic background and tobacco use), clinical (malar rash, photosensitivity, oral ulcers, discoid lesions, serositis, glomerulonephritis, convulsions, psychosis, hemolytic anemia, leukopenia, lymphocytopenia and arthritis), and serological profile (anti ds DNA, anti Ro/SS-A; anti La/SS-B, Anti RNP, Anti Sm, aCl (anticardiolipin) IgG, aCl Ig M, LA or lupus anticoagulant, rheumatoid factor and direct Coombs) were collected...
July 31, 2017: Clinical Rheumatology
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