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https://www.readbyqxmd.com/read/29166505/anogenital-warts-in-pediatric-population
#1
Miguel Costa-Silva, Inês Fernandes, Acácio Gonçalves Rodrigues, Carmen Lisboa
The approach to children with anogenital warts in the context of sexual abuse is a challenge in clinical practice. This study aims to review the current knowledge of anogenital warts in children, the forms of transmission, and the association with sexual abuse and to propose a cross-sectional approach involving all medical specialties. A systematic review of the literature was conducted in Portuguese and English from January 2000 to June 2016 using the ISI Web of Knowledge and PubMed databases. Children aged 12 years or younger were included...
September 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29165717/crystal-structure-of-nucb-a-biofilm-degrading-endonuclease
#2
Arnaud Baslé, Lorraine Hewitt, Alan Koh, Heather K Lamb, Paul Thompson, J Grant Burgess, Michael J Hall, Alastair R Hawkins, Heath Murray, Richard J Lewis
Bacterial biofilms are a complex architecture of cells that grow on moist interfaces, and are held together by a molecular glue of extracellular proteins, sugars and nucleic acids. Biofilms are particularly problematic in human healthcare as they can coat medical implants and are thus a potential source of disease. The enzymatic dispersal of biofilms is increasingly being developed as a new strategy to treat this problem. Here, we have characterized NucB, a biofilm-dispersing nuclease from a marine strain of Bacillus licheniformis, and present its crystal structure together with the biochemistry and a mutational analysis required to confirm its active site...
November 20, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29165616/work-system-assessment-to-facilitate-the-dissemination-of-a-quality-improvement-program-for-optimizing-blood-culture-use-a-case-study-using-a-human-factors-engineering-approach
#3
Anping Xie, Charlotte Z Woods-Hill, Anne F King, Heather Enos-Graves, Judy Ascenzi, Ayse P Gurses, Sybil A Klaus, James C Fackler, Aaron M Milstone
Background: Work system assessments can facilitate successful implementation of quality improvement programs. Using a human factors engineering approach, we conducted a work system assessment to facilitate the dissemination of a quality improvement program for optimizing blood culture use in pediatric intensive care units at 2 hospitals. Methods: Semistructured face-to-face interviews were conducted with clinicians from Johns Hopkins All Children's Hospital and University of Virginia Medical Center...
November 20, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29165562/the-diversity-of-recent-and-ancient-human-dream-a-new-microarray-for-genetic-anthropology-and-genealogy-forensics-and-personalized-medicine
#4
Eran Elhaik, Leeban Yusuf, Ainan I J Anderson, Mehdi Pirooznia, Dimitrios Arnellos, Gregory Vilshansky, Gunes Ercal, Yontao Lu, Teresa Webster, Michael L Baird, Umberto Esposito
The human population displays wide variety in demographic history, ancestry, content of DNA derived from hominins or ancient populations, adaptation, traits, copy number variation (CNVs), drug response, and more. These polymorphisms are of broad interest to population geneticists, forensics investigators, and medical professionals. Historically, much of that knowledge was gained from population survey projects. While many commercial arrays exist for genome-wide single-nucleotide polymorphism (SNP) genotyping, their design specifications are limited and they do not allow a full exploration of biodiversity...
November 20, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/29165122/decreased-blood-pressure-associated-with-in-vehicle-exposure-to-carbon-monoxide-in-korean-volunteers
#5
Geon-Woo Lee, Mun-Joo Bae, Ji-Yeon Yang, Jung-Woo Son, Jae-Lim Cho, Sang-Gyu Lee, Bo-Mi Jang, Hyun-Woo Lee, Jong-Soon Lim, Dong-Chun Shin, Young-Wook Lim
BACKGROUND: Carbon monoxide (CO) is one of the primary components of emissions from light-duty vehicles, and reportedly comprises 77% of all pollutants emitted in terms of concentration. Exposure to CO aggravates cardiovascular disease and causes other health disorders. The study was aimed to assess the negative effects by injecting different amounts of CO concentration directly to human volunteers boarding in the car. METHODS: Human volunteers were exposed to CO concentrations of 0, 33...
April 5, 2017: Environmental Health and Preventive Medicine
https://www.readbyqxmd.com/read/29165101/therapeutic-potentials-and-cytochrome-p450-mediated-interactions-involving-herbal-products-indicated-for-diabetes-mellitus
#6
Cyprian Ogbonna Onyeji, Sharon I Igbinoba, Gbola Olayiwola
There has been an increase in the use of herbal products to complement conventional drugs in the treatment of various diseases especially in developing countries. This may be attributable to the relatively cost-effectiveness and ease of accessibility of these products as well as the perception of their safety profiles. However, there are numerous literature reports on herbs altering the pharmacokinetics and pharmacodynamics of other co-administered drugs thereby modulating the therapeutic outcomes. The prevalence of diabetes is on a steady increase worldwide and it is now identified as one of the main threats to human health...
November 20, 2017: Drug Metabolism Letters
https://www.readbyqxmd.com/read/29164806/enhanced-cytotoxicity-and-apoptosis-by-raloxifene-in-combination-with-estrogen-and-methotrexate-in-human-endometrial-stromal-thesc-cells
#7
Ivana Nikolic, Marija Andjelkovic, Milan Zaric, Ivanka Zelen, Zoran Milosavljevic, Petar Canovic, Marina Mitrovic
Endometrial hyperplasia is a condition that may lead to the development of endometrial carcinoma. Initially, changes of the endometrium are caused by the estrogen's hyperstimulation that may lead to the development of an irregular bleeding and the infertility problems. Therapy of endometrial hyperplasia's is limited to medical and surgical approaches. During the past decade, the new types of drugs were developed for the treatment of the endometrial hyperplasia. Here, for the first time, we investigated the cytotoxic effects of the various combinations of estrogen, raloxifene and methotrexate in human ThESC cell line as a possible potential treatment of the endometrial hyperplasia...
November 22, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/29164550/-improve-the-rate-of-bone-collection-at-human-tissue-banks
#8
Jui-Mei Hsieh, Pei-Shan Chung, Shin-Pei Liu
BACKGROUND: Lack of familiarity with collection and inspection procedures, incorrect bone-packaging procedures, and unclear instructions for bone placement during storage are primary reasons for the resultant low bone collection pass rate of bone banks. Moreover, 8 cases / operations were directly affected by this problem, which caused bone-nail dislocations during the post-operative period that nearly caused medical disputes. PURPOSE: The present project was designed to improve the pass rate of the bone of the human organ to 95%...
December 2017: Hu Li za Zhi the Journal of Nursing
https://www.readbyqxmd.com/read/29164547/-the-effectiveness-of-a-strategy-for-the-flexible-management-of-nursing-human-resources-a-pilot-study
#9
Chung-I Huang, Meei-Shiow Lu
BACKGROUND: The flexibility of a hospital's nursing-related human resource management policies affects the working willingness and retention of nurses. PURPOSE: To explore the effectiveness of a flexible nursing-related human resource management strategy. METHODS: This quasi-experimental research used a one group pretest-posttest design. Supervisors at participating hospitals attended the "Application of Flexible Nursing Human Resources Management Strategies" workshop, which introduced the related measures and assessed nurses' pretest satisfaction...
December 2017: Hu Li za Zhi the Journal of Nursing
https://www.readbyqxmd.com/read/29164295/the-economic-and-social-burden-of-traumatic-injuries-evidence-from-a-trauma-hospital-in-port-au-prince-haiti
#10
Christopher Zuraik, John Sampalis, Alexa Brierre
INTRODUCTION: The cost of traumatic injury is unknown in Haiti. This study aims to examine the burden of traumatic injury of patients treated and evaluated at a trauma hospital in the capital city of Port-au-Prince. METHODS: A retrospective cross-sectional chart review study was conducted at the Hospital Bernard Mevs Project Medishare for all patients evaluated for traumatic injury from December 2015 to January 2016, as described elsewhere (Zuraik and Sampalis in World J Surg, https://doi...
November 21, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29163538/efficacy-and-safety-of-a-multistrain-probiotic-formulation-depends-from-manufacturing
#11
Vito Trinchieri, Luca Laghi, Beatrice Vitali, Carola Parolin, Ilaria Giusti, Daniela Capobianco, Paola Mastromarino, Claudio De Simone
Background: Variability in probiotics manufacturing may affect their properties, with potential implications for their efficacy and safety. This is of particular concern with probiotic products destined for use in patients with serious medical conditions, including human immunodeficiency virus (HIV) infection. The purpose of the study was to carry out a series of experiments comparing the properties of the US-made probiotic formulation originally commercialized under the brand name VSL#3(®), with those of the Italian-made formulation now commercialized under the same name...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29163330/white-matter-changes-in-hiv-women-with-a-history-of-cocaine-dependence
#12
Kathryn-Mary Wakim, Ciara J Molloy, Ryan P Bell, Lars A Ross, John J Foxe
Cocaine use is associated with the transmission of human immunodeficiency (HIV) virus through risky sexual behavior. In HIV+ individuals, cocaine use is linked with poor health outcomes, including HIV-medication non-adherence and faster disease progression. Both HIV and cocaine dependence are associated with reduced integrity of cerebral white matter (WM), but the effects of HIV during cocaine abstinence have not yet been explored. We used diffusion tensor imaging (DTI) to understand the effect of combined HIV+ serostatus and former cocaine dependence on cerebral WM integrity...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29163225/human-locomotion-in-hypogravity-from-basic-research-to-clinical-applications
#13
REVIEW
Francesco Lacquaniti, Yury P Ivanenko, Francesca Sylos-Labini, Valentina La Scaleia, Barbara La Scaleia, Patrick A Willems, Myrka Zago
We have considerable knowledge about the mechanisms underlying compensation of Earth gravity during locomotion, a knowledge obtained from physiological, biomechanical, modeling, developmental, comparative, and paleoanthropological studies. By contrast, we know much less about locomotion and movement in general under sustained hypogravity. This lack of information poses a serious problem for human space exploration. In a near future humans will walk again on the Moon and for the first time on Mars. It would be important to predict how they will move around, since we know that locomotion and mobility in general may be jeopardized in hypogravity, especially when landing after a prolonged weightlessness of the space flight...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29162871/allometric-scaling-of-skin-thickness-elasticity-viscoelasticity-to-mass-for-micro-medical-device-translation-from-mice-rats-rabbits-pigs-to-humans
#14
Jonathan C J Wei, Grant A Edwards, Darren J Martin, Han Huang, Michael L Crichton, Mark A F Kendall
Emerging micro-scale medical devices are showing promise, whether in delivering drugs or extracting diagnostic biomarkers from skin. In progressing these devices through animal models towards clinical products, understanding the mechanical properties and skin tissue structure with which they interact will be important. Here, through measurement and analytical modelling, we advanced knowledge of these properties for commonly used laboratory animals and humans (~30 g to ~150 kg). We hypothesised that skin's stiffness is a function of the thickness of its layers through allometric scaling, which could be estimated from knowing a species' body mass...
November 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29162833/the-combination-of-chk1-inhibitor-with-g-csf-overrides-cytarabine-resistance-in-human-acute-myeloid-leukemia
#15
Alessandro Di Tullio, Kevin Rouault-Pierre, Ander Abarrategi, Syed Mian, William Grey, John Gribben, Aengus Stewart, Elizabeth Blackwood, Dominique Bonnet
Cytarabine (AraC) represents the most effective single agent treatment for AML. Nevertheless, overriding AraC resistance in AML remains an unmet medical need. Here we show that the CHK1 inhibitor (CHK1i) GDC-0575 enhances AraC-mediated killing of AML cells both in vitro and in vivo, thus abrogating any potential chemoresistance mechanisms involving DNA repair. Importantly, this combination of drugs does not affect normal long-term hematopoietic stem/progenitors. Moreover, the addition of CHK1i to AraC does not generate de novo mutations and in patients' samples where AraC is mutagenic, addition of CHK1i appears to eliminate the generation of mutant clones...
November 22, 2017: Nature Communications
https://www.readbyqxmd.com/read/29162777/long-term-favorable-course-of-aspergillus-endo-myo-and-pericarditis
#16
Akiko Hayashi, Sayuki Kobayashi, Itaru Hisauchi, Takaaki Komatsu, Shiro Nakahara, Yoshihiko Sakai, Kosuke Haruki, Isao Taguchi
Here, we report on a healthy 30-year-old man with no significant medical history, who tested negative for human immunodeficiency virus antigenemia but developed Aspergillus pancarditis. A case of this kind is extremely rare, and to the best of our knowledge, this is the first report of a patient with Aspergillus pancarditis, which generally leads to a very poor outcome, who had a long-term favorable clinical course. A biopsy from the right atrium of hypertrophied atrial septum was essential for obtaining the definitive diagnosis...
November 22, 2017: International Heart Journal
https://www.readbyqxmd.com/read/29162500/the-emerging-role-of-immune-dysfunction-in-mitochondrial-diseases-as-a-paradigm-for-understanding-immunometabolism
#17
REVIEW
Senta M Kapnick, Susan E Pacheco, Peter J McGuire
Immunometabolism aims to define the role of intermediary metabolism in immune cell function, with bioenergetics and the mitochondria recently taking center stage. To date, the medical literature on mitochondria and immune function extols the virtues of mouse models in exploring this biologic intersection. While the laboratory mouse has become a standard for studying mammalian biology, this model comprises part of a comprehensive approach. Humans, with their broad array of inherited phenotypes, serve as a starting point for studying immunometabolism; specifically, patients with mitochondrial disease...
November 18, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29162429/studies-with-psychedelic-drugs-in-human-volunteers
#18
REVIEW
Edward M Sellers, Myroslava K Romach, Deborah B Leiderman
Scientific curiosity and fascination have played a key role in human research with psychedelics along with the hope that perceptual alterations and heightened insight could benefit well-being and play a role in the treatment of various neuropsychiatric disorders. These motivations need to be tempered by a realistic assessment of the hurdles to be cleared for therapeutic use. Development of a psychedelic drug for treatment of a serious psychiatric disorder presents substantial although not insurmountable challenges...
November 18, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29162320/controlled-human-infections-a-report-from-the-controlled-human-infection-models-workshop-leiden-university-medical-centre-4-6-may-2016
#19
Meta Roestenberg, Annie Mo, Peter G Kremsner, Maria Yazdanbakhsh
The principle of deliberately infecting humans with infectious agents in a controlled setting, so-called controlled human infections (CHI), is not novel. Many CHI models have a long history and were established decades ago such as the intentional exposure to yellow fever and dengue performed in the 1900's (Reed, 1902) [2]. In these times bioethics and scientific reasoning were in their infancy. Nowadays, clinical trials are highly regulated and CHI are executed worldwide. Controlled human malaria infections and influenza infections are the two most frequently practiced...
November 18, 2017: Vaccine
https://www.readbyqxmd.com/read/29161888/multiple-physiological-benefits-of-bird-s-nest-fern-asplenium-australasicum-frond-extract-for-dermatological-applications
#20
Wen-Wen Zeng, Lih-Shiuh Lai
p-coumaric acid and fucose-rich polysaccharide have been studied for many bio-functions in skin including cutaneous protection from oxidative damage and antiageing, respectively, as well as wound healing. The physiological activities of various bird's nest fern extracts (BNFE), containing considerable fucose-rich mucilage and p-coumaric acid, on fibroblast and human skin were first investigated. BNFE with higher polysaccharide content generally contributed to a better moisture holding capability. Furthermore, BNFE showed pronouncedly enhancing effect on collagen production and growth of fibroblast (NIH-3T3), clinical trial results revealed that the emulsions with 1% BNFE showed good moisturising effect and improved the elasticity of human skins effectively...
November 22, 2017: Natural Product Research
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