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https://www.readbyqxmd.com/read/28435625/developing-azeri-aphasia-screening-test-and-preliminary-validity-and-reliability
#1
Sousan Salehi, Ali Jahan, Najva Mousavi, Mazyar Hashemilar, Zohreh Razaghi, Maryam Moghadam-Salimi
Background: As there is no standard aphasia screening tool for Azeri language yet, the aim of this study was to develop an aphasia screening test with acceptable validity and reliability. Methods: The present study was conducted in two phases. In the first phase, by literature search, the screening test was designed and to obtain validity it was peer reviewed by expert panel. After collecting experts' ratings and comments, appropriate modifications were applied. For test-retest reliability in the second phase, edited test was administered in 32 patients with brain injuries, then the retest was performed two weeks later...
October 7, 2016: Iranian Journal of Neurology
https://www.readbyqxmd.com/read/28435014/maximum-likelihood-estimates-of-pairwise-rearrangement-distances
#2
Stuart Serdoz, Attila Egri-Nagy, Jeremy Sumner, Barbara R Holland, Peter D Jarvis, Mark M Tanaka, Andrew R Francis
Accurate estimation of evolutionary distances between taxa is important for many phylogenetic reconstruction methods. Distances can be estimated using a range of different evolutionary models, from single nucleotide polymorphisms to large-scale genome rearrangements. Corresponding corrections for genome rearrangement distances fall into 3 categories: Empirical computational studies, Bayesian/MCMC approaches, and combinatorial approaches. Here, we introduce a maximum likelihood estimator for the inversion distance between a pair of genomes, using a group-theoretic approach to modelling inversions introduced recently...
April 20, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28433220/comparison-of-two-minimally-invasive-techniques-and-median-sternotomy-in-aortic-valve-replacement
#3
Severin Semsroth, Raffaela Matteucci Gothe, Yvonne Rodríguez Raith, Kristof de Brabandere, Esther Hanspeter, Juliane Kilo, Markus Kofler, Ludwig Müller, Elfriede Ruttman-Ulmer, Michael Grimm
BACKGROUND: Propensity score-matched analysis of the anterolateral minithoracotomy and the partial upper hemisternotomy vs the median sternotomy approach has not been reported to date for isolated aortic valve replacement. METHODS: From 2005 to 2013, isolated aortic valve replacement was performed through a partial upper hemisternotomy in 315 patients (38.9%), through a median sternotomy in 328 patients (40.5%), and through an anterolateral minithoracotomy in 167 patients (20...
April 19, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28420326/transcriptional-changes-induced-by-bevacizumab-combination-therapy-in-responding-and-non-responding-recurrent-glioblastoma-patients
#4
Thomas Urup, Line Mærsk Staunstrup, Signe Regner Michaelsen, Kristoffer Vitting-Seerup, Marc Bennedbæk, Anders Toft, Lars Rønn Olsen, Lars Jønson, Shohreh Issazadeh-Navikas, Helle Broholm, Petra Hamerlik, Hans Skovgaard Poulsen, Ulrik Lassen
BACKGROUND: Bevacizumab combined with chemotherapy produces clinical durable response in 25-30% of recurrent glioblastoma patients. This group of patients has shown improved survival and quality of life. The aim of this study was to investigate changes in gene expression associated with response and resistance to bevacizumab combination therapy. METHODS: Recurrent glioblastoma patients who had biomarker-accessible tumor tissue surgically removed both before bevacizumab treatment and at time of progression were included...
April 18, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28410096/leave-one-out-kernel-optimization-for-shadow-detection-and-removal
#5
Tomas F Yago Vicente, Minh Hoai, Dimitris Samaras
The objective of this work is to detect shadows in images. We pose this as the problem of labeling image regions, where each region corresponds to a group of superpixels. To predict the label of each region, we train a kernel Least-Squares Support Vector Machine(LSSVM) for separating shadow and non-shadow regions. The parameters of the kernel and the classifier are jointly learned to minimize the leave-one-out cross validation error. Optimizing the leave-one-out cross validation error is typically difficult, but it can be done efficiently in our framework...
April 6, 2017: IEEE Transactions on Pattern Analysis and Machine Intelligence
https://www.readbyqxmd.com/read/28376088/the-temporal-dynamics-of-chromosome-instability-in-ovarian-cancer-cell-lines-and-primary-patient-samples
#6
Signe Penner-Goeke, Zelda Lichtensztejn, Megan Neufeld, Jennifer L Ali, Alon D Altman, Mark W Nachtigal, Kirk J McManus
Epithelial ovarian cancer (EOC) is the most prevalent form of ovarian cancer and has the highest mortality rate. Novel insight into EOC is required to minimize the morbidity and mortality rates caused by recurrent, drug resistant disease. Although numerous studies have evaluated genome instability in EOC, none have addressed the putative role chromosome instability (CIN) has in disease progression and drug resistance. CIN is defined as an increase in the rate at which whole chromosomes or large parts thereof are gained or lost, and can only be evaluated using approaches capable of characterizing genetic or chromosomal heterogeneity within populations of cells...
April 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28373677/dynamics-of-single-human-embryonic-stem-cells-and-their-pairs-a-quantitative-analysis
#7
L E Wadkin, L F Elliot, I Neganova, N G Parker, V Chichagova, G Swan, A Laude, M Lako, A Shukurov
Numerous biological approaches are available to characterise the mechanisms which govern the formation of human embryonic stem cell (hESC) colonies. To understand how the kinematics of single and pairs of hESCs impact colony formation, we study their mobility characteristics using time-lapse imaging. We perform a detailed statistical analysis of their speed, survival, directionality, distance travelled and diffusivity. We confirm that single and pairs of cells migrate as a diffusive random walk for at least 7 hours of evolution...
April 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28364006/detection-of-focal-longitudinal-changes-in-the-brain-by-subtraction-of-mr-images
#8
N Patel, M A Horsfield, C Banahan, A G Thomas, M Nath, J Nath, P B Ambrosi, E M L Chung
BACKGROUND AND PURPOSE: The detection of new subtle brain pathology on MR imaging is a time-consuming and error-prone task for the radiologist. This article introduces and evaluates an image-registration and subtraction method for highlighting small changes in the brain with a view to minimizing the risk of missed pathology and reducing fatigue. MATERIALS AND METHODS: We present a fully automated algorithm for highlighting subtle changes between multiple serially acquired brain MR images with a novel approach to registration and MR imaging bias field correction...
March 31, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28355766/-clinical-outcomes-of-single-level-lumbar-spondylolisthesis-by-minimally-invasive-transforaminal-lumbar-interbody-fusion-with-bilateral-tubular-channels
#9
Z L Zeng, L Jia, Y Yu, W Xu, X Hu, X H Zhan, Y W Jia, J J Wang, L M Cheng
Objective: To evaluate the clinical effectiveness of minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) for single-level lumbar spondylolisthesis treatment with bilateral Spotlight tubular channels. Methods: A total of 21 patients with lumbar spondylolisthesis whom underwent MIS-TLIF via bilateral Spotlight tubular channels were retrospectively analyzed from October 2014 to November 2015. The 21 patients included 11 males and 10 females ranged from 35 to 82 years (average aged 60.7 years)...
April 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/28349343/characterization-and-evaluation-of-a-peptide-based-sirna-delivery-system-in-vitro
#10
Baoling Chen, Kimoon Yoo, Wen Xu, Ran Pan, Xiao Xia Han, P Chen
Since its inception more than a decade ago, gene silencing mediated by double-stranded small interfering RNA (siRNA) has been widely investigated as a potential therapeutic approach for a variety of diseases. However, the use of siRNA is hampered by its rapid degradation and poor cellular uptake in vitro and in vivo. Recently, peptide-based carriers have been applied to siRNA delivery, as an alternative to the traditional delivery systems. Here, a histidine-containing amphipathic amino acid pairing peptide, C6M3, which can form complexes with siRNA, was used as a new siRNA delivery system...
March 27, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28329213/postoperative-pulmonary-complications-and-rehabilitation-requirements-following-lobectomy-a-propensity-score-matched-study-of-patients-undergoing-video-assisted-thoracoscopic-surgery-versus-thoracotomy%C3%A2
#11
Paula Agostini, Sebastian T Lugg, Kerry Adams, Nelia Vartsaba, Maninder S Kalkat, Pala B Rajesh, Richard S Steyn, Babu Naidu, Alison Rushton, Ehab Bishay
OBJECTIVES: : Video-assisted thoracoscopic surgical (VATS) lobectomy is increasingly used for curative intent lung cancer surgery compared to open thoracotomy due to its minimally invasive approach and associated benefits. However, the effects of the VATS approach on postoperative pulmonary complications (PPC), rehabilitation and physiotherapy requirements are unclear; our study aimed to use propensity score matching to investigate this. METHODS: Between January 2012 and January 2016 all consecutive patients undergoing lobectomy via thoracotomy or VATS were prospectively observed...
March 8, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28320653/robust-timing-calibration-for-pet-using-l1-norm-minimization
#12
David Freese, David Hsu, Derek Innes, Craig Levin
Positron Emission Tomography (PET) relies on accurate timing information to pair two 511 keV photons into a coincidence event. Calibration of time delays between detectors becomes increasingly important as the timing resolution of detector technology improves, as calibration error can quickly become a dominant source of error. Previous work has shown the maximum likelihood estimate of these delays can be calculated by least squares estimation, but that approach is not tractable for complex systems and degrades in the presence of randoms...
March 13, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28295681/monolithic-flexible-supercapacitors-integrated-into-single-sheets-of-paper-and-membrane-via-vapor-printing
#13
Andong Liu, Peter Kovacik, Nolan Peard, Wenda Tian, Hilal Goktas, Jonathan Lau, Bruce Dunn, Karen K Gleason
A novel approach to fabricate supercapacitors (SCs) via vapor printing, specifically oxidative chemical vapor deposition (oCVD), is demonstrated. Compared to stacking multiple layers into a SC, this method enables the monolithic integration of all components into a single-sheet substrate, minimizing the inactive materials and eliminating the possibility of multilayer delamination. Electrodes comprised of pseudocapacitive material, poly(3,4-ethylenedioxythiophene) (PEDOT), are deposited into both sides of a sheet of flexible porous substrate...
March 10, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28276747/proteogenomic-studies-on-cancer-drug-resistance-towards-biomarker-discovery-and-target-identification
#14
Shuyue Fu, Xiang Liu, Maochao Luo, Ke Xie, Edouard C Nice, Haiyuan Zhang, Canhua Huang
Chemoresistance is a major obstacle for current cancer treatment. Proteogenomics is a powerful multi-omics research field that uses customized protein sequence databases generated by genomic and transcriptomic information to identify novel genes (e.g. noncoding, mutation and fusion genes) from mass spectrometry-based proteomic data. By identifying aberrations that are differentially expressed between tumor and normal pairs, this approach can also be applied to validate protein variants in cancer, which may reveal the response to drug treatment...
March 6, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28240896/bridging-single-and-multireference-domains-for-electron-correlation-spin-extended-coupled-electron-pair-approximation
#15
Takashi Tsuchimochi, Seiichiro Ten-No
We propose a size-consistent generalization of the recently developed spin-extended configuration interaction with singles and doubles (ECISD), where a CI wave function is explicitly spin-projected. The size-consistent effect is effectively incorporated by treating quadruples within the formulation of coupled electron pair approximation. As in coupled-cluster theory, quadruple excitations are approximated by a disconnected product of double excitations. Despite its conceptual similarity to the standard single-reference and multireference analogues, such a generalization requires careful derivation, as the spin-projected CI space is nonorthogonal and overcomplete...
March 8, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28230532/optimization-of-volumetric-breast-density-estimation-in-digital-mammograms
#16
Katharina Holland, Albert Gubern-Merida, Ritse Mann, Nico Karssemeijer
Fibroglandular tissue volume and percent density can be estimated in unprocessed mammograms using a physics-based method, which relies on an internal reference value representing the projection of fat only. However, pixels representing fat only may not be present in dense breasts, causing an underestimation of density measurements. In this work, we investigate alternative approaches for obtaining a tissue reference value to improve density estimations, particularly in dense breasts. Two of three investigated reference values (F1, F2) are percentiles of the pixel value distribution in the breast interior (the contact area of breast and compression paddle)...
February 23, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28198979/root-length-and-alveolar-bone-level-of-impacted-canines-and-adjacent-teeth-after-orthodontic-traction-a-long-term-evaluation
#17
Aldir Cordeiro da Silva, Anderson Capistrano, Renata Rodrigues de Almeida-Pedrin, Maurício de Almeida Cardoso, Ana Cláudia de Castro Ferreira Conti, Leopoldino Capelozza
Objective: The aim of this retrospective study was to evaluate the long-term effects of orthodontic traction on root length and alveolar bone level in impacted canines and adjacent teeth. Material and Methods: Sample consisted of 16 patients (nine males and seven females), mean initial age 11 years and 8 months presenting with unilaterally maxillary impacted canines, palatally displaced, treated with the same surgical and orthodontic approach. Teeth from the impacted-canine side were assigned as Group I (GI), and contralateral teeth as control, Group II (GII)...
January 2017: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/28168752/monte-carlo-replica-exchange-based-ensemble-docking-of-protein-conformations
#18
Zhe Zhang, Uwe Ehmann, Martin Zacharias
A replica-exchange Monte Carlo (REMC) ensemble docking approach has been developed that allows efficient exploration of protein-protein docking geometries. In addition to Monte Carlo steps in translation and orientation of binding partners, possible conformational changes upon binding are included based on Monte Carlo selection of protein conformations stored as ordered pregenerated conformational ensembles. The conformational ensembles of each binding partner protein were generated by three different approaches starting from the unbound partner protein structure with a range spanning a root mean square deviation of 1-2...
February 7, 2017: Proteins
https://www.readbyqxmd.com/read/28153039/metabolomics-variable-selection-and-classification-in-the-presence-of-observations-below-the-detection-limit-using-an-extension-of-erp
#19
Mari van Reenen, Johan A Westerhuis, Carolus J Reinecke, J Hendrik Venter
BACKGROUND: ERp is a variable selection and classification method for metabolomics data. ERp uses minimized classification error rates, based on data from a control and experimental group, to test the null hypothesis of no difference between the distributions of variables over the two groups. If the associated p-values are significant they indicate discriminatory variables (i.e. informative metabolites). The p-values are calculated assuming a common continuous strictly increasing cumulative distribution under the null hypothesis...
February 2, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28143546/patient-defined-desired-outcome-success-criteria-and-expectation-in-outpatient-physical-therapy-a-longitudinal-assessment
#20
Giorgio Zeppieri, Steven Z George
BACKGROUND: Patient-centered approaches offer an alternative method in evaluating treatment outcomes. This study investigated; 1) if patient's criteria for success (satisfaction of clinical outcomes) changes from pre to post treatment, 2) whether patients who met their success criteria also meet minimal clinical important difference scores (MCIDs), and 3) if patient's success criteria differed from their expected (what the patient believes will occur) and desired (what the patient wants to occur) outcomes following intervention...
January 31, 2017: Health and Quality of Life Outcomes
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