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Minimal pairs approach

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https://www.readbyqxmd.com/read/29141048/microcirculation-in-open-vs-minimally-invasive-dorsal-stabilization-of-thoracolumbar-fractures
#1
Bergita Ganse, Miguel Pishnamaz, Philipp Kobbe, Christian Herren, Gertraud Gradl-Dietsch, Franziska Böhle, Bernd Johannes, Bong-Sung Kim, Klemens Horst, Matthias Knobe
Standard open and percutaneous minimally invasive surgical procedures co-exist in the treatment of fractures of the thoracolumbar spine. Shorter skin incisions just above the pedicles are used in minimally invasive procedures. Full-length skin incisions and invasive preparations are applied in the standard open approach. While both methods show equivalent rates of intraoperative surgical complications and comparable clinical and radiological outcomes, blood loss and operation time have shown to be decreased in minimally invasive treatment...
2017: PloS One
https://www.readbyqxmd.com/read/29138143/minimally-invasive-stand-alone-cox-maze-procedure-for-persistent-and-long-standing-persistent-atrial-fibrillation-perioperative-safety-and-5-year-outcomes
#2
Niv Ad, Sari D Holmes, Ted Friehling
BACKGROUND: Rhythm control is challenging in patients with extended atrial fibrillation (AF) duration and persistent/long-standing persistent AF. Among surgical approaches to treat AF, the Cox maze procedure performed using alternative energy sources remains superior to other beating heart techniques. We examined permanence of safety and success for the on-pump, minimally invasive, stand-alone Cox maze procedure 5 years after surgery. METHODS AND RESULTS: Stand-alone, right 5 cm minithoracotomy, Cox maze III/IV procedure for nonparoxysmal AF was conducted in 133 patients (mean follow-up=65±34 months)...
November 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29121998/circulating-brain-enriched-micrornas-as-novel-biomarkers-for-detection-and-differentiation-of-neurodegenerative-diseases
#3
Kira S Sheinerman, Jon B Toledo, Vladimir G Tsivinsky, David Irwin, Murray Grossman, Daniel Weintraub, Howard I Hurtig, Alice Chen-Plotkin, David A Wolk, Leo F McCluskey, Lauren B Elman, John Q Trojanowski, Samuil R Umansky
BACKGROUND: Minimally invasive specific biomarkers of neurodegenerative diseases (NDs) would facilitate patient selection and disease progression monitoring. We describe the assessment of circulating brain-enriched microRNAs as potential biomarkers for Alzheimer's disease (AD), frontotemporal dementia (FTD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS). METHODS: In this case-control study, the plasma samples were collected from 250 research participants with a clinical diagnosis of AD, FTD, PD, and ALS, as well as from age- and sex-matched control subjects (n = 50 for each group), recruited from 2003 to 2015 at the University of Pennsylvania Health System, including the Alzheimer's Disease Center, the Parkinson's Disease and Movement Disorders Center, the Frontotemporal Degeneration Center, and the Amyotrophic Lateral Sclerosis Clinic...
November 9, 2017: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/29111154/robot-assisted-partial-nephrectomy-5-yr-oncological-outcomes-at-a-single-european-tertiary-cancer-center
#4
Mihai Dorin Vartolomei, Deliu Victor Matei, Giuseppe Renne, Valeria Maria Tringali, Nicolae Crisan, Gennaro Musi, Francesco Alessandro Mistretta, Andrea Russo, Gabriele Cozzi, Giovani Cordima, Stefano Luzzago, Antonio Cioffi, Ettore Di Trapani, Michele Catellani, Maurizio Delor, Danilo Bottero, Ciro Imbimbo, Vincenzo Mirone, Matteo Ferro, Ottavio de Cobelli
BACKGROUND: Nowadays, there is a debate about which surgical treatment should be best for clinical T1 renal tumors. If the oncological outcomes are considered, there are many open and laparoscopic series published. As far as robotic series are concerned, only a few of them report 5-yr oncological outcomes. OBJECTIVE: The aim of this study was to analyze robot-assisted partial nephrectomy (RAPN) midterm oncological outcomes achieved in a tertiary robotic reference center...
October 27, 2017: European Urology Focus
https://www.readbyqxmd.com/read/29098167/mesh-to-raster-region-of-interest-based-nonrigid-registration-of-multimodal-images
#5
Rosalia Tatano, Benjamin Berkels, Thomas M Deserno
Region of interest (RoI) alignment in medical images plays a crucial role in diagnostics, procedure planning, treatment, and follow-up. Frequently, a model is represented as triangulated mesh while the patient data is provided from computed axial tomography scanners as pixel or voxel data. Previously, we presented a 2-D method for curve-to-pixel registration. This paper contributes (i) a general mesh-to-raster framework to register RoIs in multimodal images; (ii) a 3-D surface-to-voxel application, and (iii) a comprehensive quantitative evaluation in 2-D using ground truth (GT) provided by the simultaneous truth and performance level estimation (STAPLE) method...
October 2017: Journal of Medical Imaging
https://www.readbyqxmd.com/read/29067584/impact-of-surgical-approach-on-perioperative-and-long-term-outcomes-following-esophagectomy-for-esophageal-cancer
#6
Negar Ahmadi, Agnes Crnic, Andrew J Seely, Sudhir R Sundaresan, P James Villeneuve, Donna E Maziak, Farid M Shamji, Sebastien Gilbert
BACKGROUND: Surgical resection remains a critical component of esophageal cancer treatment with curative-intent. The aim of this study was to compare open (OE) to minimally invasive Ivor Lewis esophagectomy (MIE) with respect to perioperative and oncologic outcomes. METHODS: Retrospective single-institution review of MIE and OE patients operated between 2001 and 2015 was conducted. Univariable and multivariable models were created using Cox regression. The Kaplan-Meier method was used to compare oncologic outcomes...
October 24, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29054437/method-optimization-for-drug-impurity-profiling-in-supercritical-fluid-chromatography-application-to-a-pharmaceutical-mixture
#7
Charlene Muscat Galea, David Didion, David Clicq, Debby Mangelings, Yvan Vander Heyden
A supercritical chromatographic method for the separation of a drug and its impurities has been developed and optimized applying an experimental design approach and chromatogram simulations. Stationary phase screening was followed by optimization of the modifier and injection solvent composition. A design-of-experiment (DoE) approach was then used to optimize column temperature, back-pressure and the gradient slope simultaneously. Regression models for the retention times and peak widths of all mixture components were built...
December 1, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29044157/facilitating-identification-of-minimal-protein-binding-domains-by-cross-linking-mass-spectrometry
#8
Qingyang Liu, Sanne Remmelzwaal, Albert J R Heck, Anna Akhmanova, Fan Liu
Characterization of protein interaction domains is crucial for understanding protein functions. Here we combine cross-linking mass spectrometry (XL-MS) with deletion analysis to accurately locate minimal protein interaction domains. As a proof of concept, we investigated in detail the binding interfaces of two protein assemblies: the complex formed by MICAL3, ELKS and Rab8A, which is involved in exocytosis, and the complex of SLAIN2, CLASP2 and ch-TOG, which controls microtubule dynamics. We found that XL-MS provides valuable information to efficiently guide the design of protein fragments that are essential for protein interaction...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29030445/microhomology-mediated-high-throughput-gene-inactivation-strategy-for-hyperthermophilic-crenarchaeon-sulfolobus-islandicus
#9
Changyi Zhang, Rachel J Whitaker
Sulfolobus islandicus is rapidly emerging as a model system for studying the biology and evolution within the TACK lineage of the Archaeal domain. As the tree of life grows, identifying the cellular function of genes within this lineage will have significant impacts on our understanding of the evolution of Last Archaeal Eukaryote Common Ancestor (LEACA) and the differentiation of Archaea from Eukaryotes during the evolution of the modernday cell. To progress our understanding of this key Archaeal organism, we report a novel high-throughput method for targeted gene inactivation in S...
October 13, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29025899/a-novel-single-beat-approach-to-assess-right-ventricular-systolic-function
#10
Alessandro Bellofiore, Rebecca R Vanderpool, Melanie J Brewis, Andrew J Peacock, Naomi C Chesler
Clinical assessment of right ventricular (RV) contractility in diseases such as pulmonary arterial hypertension (PAH) has been hindered by the lack of a robust methodology. Here, a novel clinically-viable single-beat method was developed to assess end-systolic elastance (Ees), a measure of RV contractility. We hypothesized that this novel approach reduces uncertainty and interobserver variability in the estimation of the maximum isovolumic pressure (Piso), the key step in single-beat methods. The new method was designed to include a larger portion of the RV pressure data and minimize subjective adjustments by the operator...
October 12, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29024292/hepatic-cystic-echinococcosis-in-australia-an-update-on-diagnosis-and-management
#11
REVIEW
Ben Keong, Bruce Wilkie, Tom Sutherland, Adrian Fox
BACKGROUND: Echinococcosis is an uncommonly encountered zoonotic disease caused by the taeniid Echinococcus. The only endemic species in Australia, Echinococcus granulosus, forms cysts in the liver in 70% of cases. The aim of this study was to review the literature to provide an evidence-based narrative update on the diagnosis and management of hepatic cystic echinococcosis in Australia. METHODS: We reviewed the literature, utilizing multiple research databases and citation tracking...
October 11, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29022384/does-the-maternal-vaginal-microbiota-play-a-role-in-seeding-the-microbiota-of-neonatal-gut-and-nose
#12
O Sakwinska, F Foata, B Berger, H Brüssow, S Combremont, A Mercenier, S Dogra, S-E Soh, J C K Yen, G Y S Heong, Y S Lee, F Yap, M J Meaney, Y-S Chong, K M Godfrey, J D Holbrook
The acquisition and early maturation of infant microbiota is not well understood despite its likely influence on later health. We investigated the contribution of the maternal microbiota to the microbiota of infant gut and nose in the context of mode of delivery and feeding. Using 16S rRNA sequencing and specific qPCR, we profiled microbiota of 42 mother-infant pairs from the GUSTO birth cohort, at body sites including maternal vagina, rectum and skin; and infant stool and nose. In our study, overlap between maternal vaginal microbiota and infant faecal microbiota was minimal, while the similarity between maternal rectal microbiota and infant microbiota was more pronounced...
October 12, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/28984511/interbody-distraction-and-vertebral-body-reconstruction-with-polymethylmethacrylate-for-the-treatment-of-pathological-fractures
#13
Scott L Zuckerman, Ganesh Rao, Laurence D Rhines, Ian E McCutcheon, Richard G Everson, Claudio E Tatsui
OBJECTIVE Treatment of epidural spinal cord compression (ESCC) caused by tumor includes surgical decompression and stabilization followed by postoperative radiation. In the case of severe axial loading impairment, anterior column reconstruction is indicated. The authors describe the use of interbody distraction to restore vertebral body height and correct kyphotic angulation prior to reconstruction with polymethylmethacrylate (PMMA), and report the long-term durability of such reconstruction. METHODS A single institution, prospective series of patients with ESCC undergoing single-stage decompression, anterior column reconstruction, and posterior instrumentation from 2013 to 2016 was retrospectively analyzed...
October 6, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28962509/trans-right-axillary-aortic-valve-replacement-propensity-matched-comparison-with-standard-sternotomy-approach
#14
Masayoshi Tokoro, Toshiaki Ito, Atsuo Maekawa, Sadanari Sawaki, Junji Yanagisawa, Takahiro Ozeki, Mamoru Orii
OBJECTIVES: We developed trans-right axillary aortic valve replacement (TAX-AVR) as a more cosmetically superior approach to minimally invasive AVR. We herein retrospectively compared the safety and invasiveness between TAX-AVR and conventional AVR (C-AVR). METHODS: TAX-AVR was performed under femorofemoral cardiopulmonary bypass. Creation of a small right axillary vertical skin incision was followed by anterolateral intercostal thoracotomy. AVR was performed using long-shafted minimally invasive instruments, a knot pusher and endoscopic assistance...
October 1, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28960310/novel-targets-for-sensitizing-breast-cancer-cells-to-trail-induced-apoptosis-with-sirna-delivery
#15
Bindu Thapa, Remant Bahadur Kc, Hasan Uludağ
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in variety of cancer cells without affecting most normal cells, which makes it a promising agent for cancer therapy. However, TRAIL therapy is clinically not effective due to resistance induction. To identify novel regulators of TRAIL that can aid in therapy, protein targets whose silencing sensitized breast cancer cells against TRAIL were screened with an siRNA library against 446 human apoptosis-related proteins in MDA-231 cells...
September 27, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28959386/cerebrospinal-fluid-extracellular-vesicle-enrichment-for-protein-biomarker-discovery-in-neurological-disease-multiple-sclerosis
#16
Joanne L Welton, Samantha Loveless, Timothy Stone, Chris von Ruhland, Neil P Robertson, Aled Clayton
The discovery of disease biomarkers, along with the use of "liquid biopsies" as a minimally invasive source of biomarkers, continues to be of great interest. In inflammatory diseases of the central nervous system (CNS), cerebrospinal fluid (CSF) is the most obvious biofluid source. Extracellular vesicles (EVs) are also present in CSF and are thought to be potential "biomarker treasure chests". However, isolating these CSF-derived EVs remains challenging. This small-scale pilot study developed and tested a protocol to enrich for CSF-EVs, both in relapsing remitting multiple sclerosis (RRMS) CSF and controls...
2017: Journal of Extracellular Vesicles
https://www.readbyqxmd.com/read/28951042/node-to-node-field-calibration-of-wireless-distributed-air-pollution-sensor-network
#17
Fadi Kizel, Yael Etzion, Rakefet Shafran-Nathan, Ilan Levy, Barak Fishbain, Alena Bartonova, David M Broday
Low-cost air quality sensors offer high-resolution spatiotemporal measurements that can be used for air resources management and exposure estimation. Yet, such sensors require frequent calibration to provide reliable data, since even after a laboratory calibration they might not report correct values when they are deployed in the field, due to interference with other pollutants, as a result of sensitivity to environmental conditions and due to sensor aging and drift. Field calibration has been suggested as a means for overcoming these limitations, with the common strategy involving periodical collocations of the sensors at an air quality monitoring station...
September 23, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28949453/somatic-mutation-detection-using-various-targeted-detection-assays-in-paired-samples-of-circulating-tumor-dna-primary-tumor-and-metastases-from-patients-undergoing-resection-of-colorectal-liver-metastases
#18
(no author information available yet)
Assessing circulating tumor DNA (ctDNA) is a promising method to evaluate somatic mutations from solid tumors in a minimally-invasive way. In a group of twelve metastatic colorectal cancer (mCRC) patients undergoing liver metastasectomy, from each patient DNA from cell-free DNA (cfDNA), the primary tumor, metastatic liver tissue, normal tumor-adjacent colon or liver tissue, and whole blood were obtained. Investigated was the feasibility of a targeted NGS approach to identify somatic mutations in ctDNA. This targeted NGS approach was also compared with NGS preceded by mutant allele enrichment using synchronous coefficient of drag alteration technology embodied in the OnTarget assay, and for selected mutations with digital PCR (dPCR)...
December 2016: Molecular Oncology
https://www.readbyqxmd.com/read/28938317/postoperative-changes-in-isolated-medial-orbital-wall-fractures-based-on-computed-tomography
#19
Soyeon Jung, Jang Won Lee, Chung Hun Kim, Euna Hwang, Hyoseob Lim, Sung Won Jung, Sung Hoon Koh
The treatment has been improved on the accurate reduction of blow-out fracture for many decades. But still, it has been limited to reduce completely when surgeons are approaching by conventional technique. The authors analyzed the postoperative results using computed tomography (CT) scans after conventional open reduction of isolated medial wall fracture. Thirty-seven patients with isolated medial wall fracture were reviewed. All patients underwent preoperative, immediate, and postoperative CT scans. Two surgeons have performed the surgery by conventional open reduction with transcaruncular approach and absorbable mesh insertion...
November 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28927778/introducing-nerve-sparing-approach-during-minimally-invasive-radical-hysterectomy-for-locally-advanced-cervical-cancer-a-multi-institutional-experience
#20
Francesco Raspagliesi, Giorgio Bogani, Arsenio Spinillo, Antonino Ditto, Stefano Bogliolo, Jvan Casarin, Umberto Leone Roberti Maggiore, Fabio Martinelli, Mauro Signorelli, Barbara Gardella, Valentina Chiappa, Cono Scaffa, Simone Ferrero, Antonella Cromi, Domenica Lorusso, Fabio Ghezzi
OBJECTIVE: To evaluate the impact of nerve-sparing (NS) approach on outcomes of patients undergoing minimally invasive radical hysterectomy (MRH) for locally advanced stage cervical cancer (LACC). METHODS: Data of consecutive patients undergoing minimally invasive surgery for LACC were retrospectively retrieved in a multi-institutional setting from 2009 to 2016. All patients included had minimally invasive class III radical hysterectomy (MRH or NS-MRH). Propensity matching algorithm was used to decrease possible allocation bias when comparing outcomes between groups...
September 7, 2017: European Journal of Surgical Oncology
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