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https://www.readbyqxmd.com/read/29316303/feasibility-study-of-modeling-liver-thermal-damage-using-minimally-invasive-optical-method-adequate-for-in-situ-measurement
#1
Jinzhe Zhao, Qi Zhao, Yingxu Jiang, Weitao Li, Yamin Yang, Zhiyu Qian, Jia Liu
Liver thermal ablation techniques have been widely used for the treatment of liver cancer. Kinetic model of damage propagation play an important role for ablation prediction and real-time efficacy assessment. However, practical methods for modeling liver thermal damage are rare. A minimally invasive optical method especially adequate for in situ liver thermal damage modeling is introduced in this paper. Porcine liver tissue was heated by water bath under different temperatures. During thermal treatment, diffuse reflectance spectrum (DRS) of liver was measured by optical fiber and used to deduce reduced scattering coefficient (μ's )...
January 9, 2018: Journal of Biophotonics
https://www.readbyqxmd.com/read/29304201/short-term-outcomes-of-minimally-invasive-mitral-valve-repair-a-propensity-matched-comparison
#2
Qing Wang, Wang Xi, Yang Gao, Hua Shen, Jie Min, Jie Yang, Shiguan Le, Yufeng Zhang, Zhinong Wang
OBJECTIVES: We aimed to investigate the effect of minimally invasive mitral valve repair on early pulmonary function and haemodynamics, as well as its short-term efficacy. METHODS: From March 2012 to July 2015, 78 cases of minimally invasive mitral valve repair and 89 cases of conventional mitral valve repair were included in this study, with 67 well-matched pairs of patients identified by a propensity score matching, who were divided into the conventional sternotomy group and the right minithoracotomy group (the RT group)...
January 3, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29298117/association-of-cell-free-dna-tumor-fraction-and-somatic-copy-number-alterations-with-survival-in-metastatic-triple-negative-breast-cancer
#3
Daniel G Stover, Heather A Parsons, Gavin Ha, Samuel S Freeman, William T Barry, Hao Guo, Atish D Choudhury, Gregory Gydush, Sarah C Reed, Justin Rhoades, Denisse Rotem, Melissa E Hughes, Deborah A Dillon, Ann H Partridge, Nikhil Wagle, Ian E Krop, Gad Getz, Todd R Golub, J Christopher Love, Eric P Winer, Sara M Tolaney, Nancy U Lin, Viktor A Adalsteinsson
Purpose Cell-free DNA (cfDNA) offers the potential for minimally invasive genome-wide profiling of tumor alterations without tumor biopsy and may be associated with patient prognosis. Triple-negative breast cancer (TNBC) is characterized by few mutations but extensive somatic copy number alterations (SCNAs), yet little is known regarding SCNAs in metastatic TNBC. We sought to evaluate SCNAs in metastatic TNBC exclusively via cfDNA and determine if cfDNA tumor fraction is associated with overall survival in metastatic TNBC...
January 3, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29290134/minimally-invasive-anterior-and-lateral-transpsoas-approaches-for-closed-reduction-of-grade-ii-spondylolisthesis-initial-clinical-and-radiographic-experience
#4
David S Xu, Konrad Bach, Juan S Uribe
OBJECTIVE Minimally invasive anterior and lateral approaches to the lumbar spine are increasingly used to treat and reduce grade I spondylolisthesis, but concerns still exist for their usage in the management of higher-grade lesions. The authors report their experience with this strategy for grade II spondylolisthesis in a single-surgeon case series and provide early clinical and radiographic outcomes. METHODS A retrospective review of a single surgeon's cases between 2012 and 2016 identified all patients with a Meyerding grade II lumbar spondylolisthesis who underwent minimally invasive lateral lumbar interbody fusion (LLIF) or anterior lumbar interbody fusion (ALIF) targeting the slipped level...
January 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29238153/risk-factors-for-open-conversion-in-minimally-invasive-cholecystectomy
#5
Antonio Gangemi, Richard Danilkowicz, Francesco Bianco, Mario Masrur, Pier Cristoforo Giulianotti
Background and Objectives: Open conversion (OC) occurs in 5 to 10% of laparoscopic cholecystectomies (LCs) and results in suboptimal outcomes. Herein, we report our experience with OC in cholecystectomy performed with the minimally invasive (MIS) approach. Methods: Data from 960 minimally invasive cholecystectomies performed in the University of Illinois at Chicago (UIC) Division of General, Minimally Invasive, and Robotic Surgery were retrospectively compiled. Patient demographics and outcomes were analyzed for the major indicators that may predispose to OC...
October 2017: JSLS: Journal of the Society of Laparoendoscopic Surgeons
https://www.readbyqxmd.com/read/29236621/helping-hispanic-dementia-caregivers-cope-with-stress-using-technology-based-resources
#6
Bruno Kajiyama, Gerardo Fernandez, Elizabeth A Carter, Marika B Humber, Larry W Thompson
OBJECTIVES: The objectives of this study were to develop and evaluate a culturally appropriate intervention for Hispanic/Latino caregivers of individuals with dementia, using a structured online program without professional involvement to improve well-being, decrease stress, and reduce depression. METHODS: The Webnovela Mirela, an online Spanish-language telenovela, was designed specifically to teach caregivers how to cope with dementia caregiving. A prototype of Webnovela Mirela was tested in a pilot study with 25 Hispanic/Latino dementia caregivers, 19 of whom completed the study...
September 15, 2017: Clinical Gerontologist
https://www.readbyqxmd.com/read/29224159/quantitation-of-dna-methylation-by-quantitative-multiplex-methylation-specific-pcr-qm-msp-assay
#7
Mary Jo Fackler, Saraswati Sukumar
The defining feature of the Quantitative Multiplex Methylation-Specific PCR (QM-MSP) method to sensitively quantify DNA methylation is the two-step PCR approach for a multiplexed analysis of a panel of up to 12 genes in clinical samples with minimal quantities of DNA. In the first step, for up to 12 genes tested, one pair of gene-specific primers (forward and reverse) amplifies the methylated and unmethylated copies of the same gene simultaneously and in multiplex, in one PCR reaction. This methylation-independent amplification step produces amplicons of up to 109 copies per μL after 36 cycles of PCR...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29221931/urethral-rest-with-suprapubic-cystostomy-in-obliterative-or-nearly-obliterative-urethral-strictures-urethrographic-changes-and-implications-for-management
#8
T Moncrief, R A Gor, R A Goldfarb, S Jarosek, S P Elliott
OBJECTIVE: Precise pre-operative urethral stricture characterization is important for surgical planning. A period of urethral rest by suprapubic cystostomy tube may aid in stricture characterization and may affect the surgical approach. We compare the radiographic characterization of anterior urethral strictures by fellowship-trained reconstructive urologists before and after a period of urethral rest. We then determine how this changed the planned operative approach. METHODS: We queried our prospectively maintained urethroplasty database at the University of Minnesota for men with anterior urethral stricture who had retrograde urethrogram (RUG) and voiding cystourethrogram (VCUG) both before and after pre-operative suprapubic cystostomy tube (SPC) placement (n=29)...
December 5, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29218675/thoracotomy-versus-video-assisted-thoracoscopic-surgery-vats-in-stage-iii-empyema-an-analysis-of-217-consecutive-patients
#9
Martin Reichert, Bernd Pösentrup, Andreas Hecker, Emmanuel Schneck, Jörn Pons-Kühnemann, Florian Augustin, Winfried Padberg, Dietmar Öfner, Johannes Bodner
BACKGROUND: Pleural empyema is an infectious disease of the chest cavity, with a high morbidity and mortality. According to the American Thoracic Society, pleural empyema gets graduated into three stages, with surgery being indicated in intermediate stage II and chronic stage III. Evidence for the feasibility of a minimally-invasive video-assisted thoracoscopic approach in stage III empyema for pulmonary decortication is still little. METHODS: Retrospective single-center analysis of patients conducted to surgery for chronic stage III pleural empyema from 05/2002 to 04/2014 either by video-assisted thoracoscopic surgery (VATS, n = 110) or conventional open surgery by thoracotomy (n = 107)...
December 7, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29206693/long-term-results-of-suture-annuloplasty-for-degenerative-mitral-valve-disease-a-propensity-matched-analysis
#10
Andrea Garatti, Alberto Canziani, Alessandro Parolari, Serenella Castelvecchio, Marco Guazzi, Andrea Daprati, Ali Abu Farah, Francesco Grimaldi, Sonia Tripepi, Lorenzo Menicanti
AIMS: Ring annuloplasty is the gold standard of surgical repair in degenerative mitral valve disease. However, prosthetic annuloplasty has some drawbacks and potential hazards. Suture annuloplasty theoretically is able to preserve annular leaflet dynamics and left ventricular performance, but experience is limited. The aim of the study was to review the early and long-term outcome of the posterior double-suture annuloplasty (DSA) technique for degenerative mitral valve repair. METHODS: From January 2002 to December 2008, 400 patients underwent primary mitral valve repair for degenerative disease either with posterior DSA [n = 147 (37%)] or with flexible posterior annuloplasty band [n = 253 (63%)]...
January 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29192912/quantitative-profiling-of-carbonyl-metabolites-directly-in-crude-biological-extracts-using-chemoselective-tagging-and-nanoesi-ftms
#11
Pan Deng, Richard M Higashi, Andrew N Lane, Ronald C Bruntz, Ramon C Sun, Mandapati V Ramakrishnam Raju, Michael H Nantz, Zhen Qi, Teresa W-M Fan
The extensive range of chemical structures, wide range of abundances, and chemical instability of metabolites present in the metabolome pose major analytical challenges that are difficult to address with existing technologies. To address these issues, one approach is to target a subset of metabolites that share a functional group, such as ketones and aldehydes, using chemoselective tagging. Here we report a greatly improved chemoselective method for the quantitative analysis of hydrophilic and hydrophobic carbonyl-containing metabolites directly in biological samples...
December 1, 2017: Analyst
https://www.readbyqxmd.com/read/29188492/investigating-the-effects-of-subconcussion-on-functional-connectivity-using-mass-univariate-and-multivariate-approaches
#12
Bryson B Reynolds, Amanda N Stanton, Sauson Soldozy, Howard P Goodkin, Max Wintermark, T Jason Druzgal
There are concerns about the effects of subconcussive head impacts in sport, but the effects of subconcussion on brain connectivity are not well understood. We hypothesized that college football players experience changes in brain functional connectivity not found in athletes competing in lower impact sports or healthy controls. These changes may be spatially heterogeneous across participants, requiring analysis methods that go beyond mass-univariate approaches commonly used in functional MRI (fMRI). To test this hypothesis, we analyzed resting-state fMRI data from college football (n = 15), soccer (n = 12), and lacrosse players (n = 16), and controls (n = 29) collected at preseason and postseason time points...
November 29, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29177986/metallurgy-of-soft-spheres-with-hard-core-from-bcc-to-frank-kasper-phases
#13
Brigitte Pansu, Jean-François Sadoc
Understanding how soft particles can fill the space is still an open question. Structures far from classical FCC or BCC phases are now commonly experimentally observed in many different systems. Models based on pair interaction between soft particles are at present much studied in 2D. Pair interactions with two different lengths have been shown to lead to quasicrystalline architectures. It is also the case for a hard core with a square repulsive shoulder potential. In 3D, global approaches have been proposed for instance by minimizing the interface area between the deformed objects in the case of foams or micellar systems or using a self-consistent mean-field theory in copolymer melts...
November 24, 2017: European Physical Journal. E, Soft Matter
https://www.readbyqxmd.com/read/29163521/cd4-and-perivascular-foxp3-t-cells-in-glioma-correlate-with-angiogenesis-and-tumor-progression
#14
Luyan Mu, Changlin Yang, Qiang Gao, Yu Long, Haitao Ge, Gabriel DeLeon, Linchun Jin, Yifan Emily Chang, Elias J Sayour, Jingjing Ji, Jie Jiang, Paul S Kubilis, Jiping Qi, Yunhe Gu, Jiabin Wang, Yuwen Song, Duane A Mitchell, Zhiguo Lin, Jianping Huang
Background: Angiogenesis and immune cell infiltration are key features of gliomas and their manipulation of the microenvironment, but their prognostic significance remains indeterminate. We evaluate the interconnection between tumor-infiltrating lymphocyte (TIL) and tumor blood-vasculatures in the context of glioma progression. Methods: Paired tumor tissues of 44 patients from three tumor-recurrent groups: diffuse astrocytomas (DA) recurred as DA, DA recurred as glioblastomas (GBM), and GBM recurred as GBM were evaluated by genetic analysis, immunohistochemistry for tumor blood vessel density, TIL subsets, and clinical outcomes...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29157200/swellix-a-computational-tool-to-explore-rna-conformational-space
#15
Nathan Sloat, Jui-Wen Liu, Susan J Schroeder
BACKGROUND: The sequence of nucleotides in an RNA determines the possible base pairs for an RNA fold and thus also determines the overall shape and function of an RNA. The Swellix program presented here combines a helix abstraction with a combinatorial approach to the RNA folding problem in order to compute all possible non-pseudoknotted RNA structures for RNA sequences. The Swellix program builds on the Crumple program and can include experimental constraints on global RNA structures such as the minimum number and lengths of helices from crystallography, cryoelectron microscopy, or in vivo crosslinking and chemical probing methods...
November 21, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/29141048/microcirculation-in-open-vs-minimally-invasive-dorsal-stabilization-of-thoracolumbar-fractures
#16
Bergita Ganse, Miguel Pishnamaz, Philipp Kobbe, Christian Herren, Gertraud Gradl-Dietsch, Franziska Böhle, Bernd Johannes, Bong-Sung Kim, Klemens Horst, Matthias Knobe
Standard open and percutaneous minimally invasive surgical procedures co-exist in the treatment of fractures of the thoracolumbar spine. Shorter skin incisions just above the pedicles are used in minimally invasive procedures. Full-length skin incisions and invasive preparations are applied in the standard open approach. While both methods show equivalent rates of intraoperative surgical complications and comparable clinical and radiological outcomes, blood loss and operation time have shown to be decreased in minimally invasive treatment...
2017: PloS One
https://www.readbyqxmd.com/read/29138143/minimally-invasive-stand-alone-cox-maze-procedure-for-persistent-and-long-standing-persistent-atrial-fibrillation-perioperative-safety-and-5-year-outcomes
#17
Niv Ad, Sari D Holmes, Ted Friehling
BACKGROUND: Rhythm control is challenging in patients with extended atrial fibrillation (AF) duration and persistent/long-standing persistent AF. Among surgical approaches to treat AF, the Cox maze procedure performed using alternative energy sources remains superior to other beating heart techniques. We examined permanence of safety and success for the on-pump, minimally invasive, stand-alone Cox maze procedure 5 years after surgery. METHODS AND RESULTS: Stand-alone, right 5 cm minithoracotomy, Cox maze III/IV procedure for nonparoxysmal AF was conducted in 133 patients (mean follow-up=65±34 months)...
November 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29121998/circulating-brain-enriched-micrornas-as-novel-biomarkers-for-detection-and-differentiation-of-neurodegenerative-diseases
#18
Kira S Sheinerman, Jon B Toledo, Vladimir G Tsivinsky, David Irwin, Murray Grossman, Daniel Weintraub, Howard I Hurtig, Alice Chen-Plotkin, David A Wolk, Leo F McCluskey, Lauren B Elman, John Q Trojanowski, Samuil R Umansky
BACKGROUND: Minimally invasive specific biomarkers of neurodegenerative diseases (NDs) would facilitate patient selection and disease progression monitoring. We describe the assessment of circulating brain-enriched microRNAs as potential biomarkers for Alzheimer's disease (AD), frontotemporal dementia (FTD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS). METHODS: In this case-control study, the plasma samples were collected from 250 research participants with a clinical diagnosis of AD, FTD, PD, and ALS, as well as from age- and sex-matched control subjects (n = 50 for each group), recruited from 2003 to 2015 at the University of Pennsylvania Health System, including the Alzheimer's Disease Center, the Parkinson's Disease and Movement Disorders Center, the Frontotemporal Degeneration Center, and the Amyotrophic Lateral Sclerosis Clinic...
November 9, 2017: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/29111154/robot-assisted-partial-nephrectomy-5-yr-oncological-outcomes-at-a-single-european-tertiary-cancer-center
#19
Mihai Dorin Vartolomei, Deliu Victor Matei, Giuseppe Renne, Valeria Maria Tringali, Nicolae Crisan, Gennaro Musi, Francesco Alessandro Mistretta, Andrea Russo, Gabriele Cozzi, Giovani Cordima, Stefano Luzzago, Antonio Cioffi, Ettore Di Trapani, Michele Catellani, Maurizio Delor, Danilo Bottero, Ciro Imbimbo, Vincenzo Mirone, Matteo Ferro, Ottavio de Cobelli
BACKGROUND: Nowadays, there is a debate about which surgical treatment should be best for clinical T1 renal tumors. If the oncological outcomes are considered, there are many open and laparoscopic series published. As far as robotic series are concerned, only a few of them report 5-yr oncological outcomes. OBJECTIVE: The aim of this study was to analyze robot-assisted partial nephrectomy (RAPN) midterm oncological outcomes achieved in a tertiary robotic reference center...
October 27, 2017: European Urology Focus
https://www.readbyqxmd.com/read/29098167/mesh-to-raster-region-of-interest-based-nonrigid-registration-of-multimodal-images
#20
Rosalia Tatano, Benjamin Berkels, Thomas M Deserno
Region of interest (RoI) alignment in medical images plays a crucial role in diagnostics, procedure planning, treatment, and follow-up. Frequently, a model is represented as triangulated mesh while the patient data is provided from computed axial tomography scanners as pixel or voxel data. Previously, we presented a 2-D method for curve-to-pixel registration. This paper contributes (i) a general mesh-to-raster framework to register RoIs in multimodal images; (ii) a 3-D surface-to-voxel application, and (iii) a comprehensive quantitative evaluation in 2-D using ground truth (GT) provided by the simultaneous truth and performance level estimation (STAPLE) method...
October 2017: Journal of Medical Imaging
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