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JOURNAL ARTICLE
A Arun Prince Milton, Samir Das, Kasanchi M Momin, M C B Prasad, Sabia Khan, G Bhuvana Priya, Sandeep Ghatak, Arnab Sen, K K Baruah
African swine fever (ASF) is a highly fatal and contagious viral disease caused by African swine fever virus (ASFV). It has caused significant economic losses to the swine industry and poses a serious threat to food security worldwide. Diagnostic tests with high sensitivity are essential for the effective management of ASF. Here, we describe a single-tube nested PCR (STN-PCR) assay for the detection of ASFV in which two consecutive amplification steps are carried out within a single tube. Two pairs of primers (outer and inner) were designed to target the p72 gene of ASFV...
April 22, 2024: Archives of Virology
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JOURNAL ARTICLE
Jishnu Sai Gopinath, Pattiyil Parameswaran
Pentacycloundecanylidene was spectroscopically identified during the photolysis of the corresponding aziridine and its aerial oxidation results in the corresponding ketone. Here we report the role of hyperconjugative interactions in stabilizing the singlet pentacycloundecanylidene and its corresponding ketone pentacycloundecanone. The pentacycloundecanylidene possesses a singlet ground state with two possible geometrical isomers based on the orientation of the carbene bridge (U1 and U2). The energy difference between U1 and U2 is minimal (0...
April 22, 2024: Physical Chemistry Chemical Physics: PCCP
#3
JOURNAL ARTICLE
Stephen K Wilke, Chris J Benmore, Vrishank Menon, Dan Smith, Stephen R Byrn, Richard Weber
Amorphous solid dispersions (ASDs) are a widely studied formulation approach for improving the bioavailability of poorly water-soluble pharmaceuticals. Yet, a complete understanding remains lacking for how specific processing methods may influence ASDs' molecular structure. We prepare ketoprofen/polyvinylpyrrolidone (KTP/PVP) ASDs, ranging from 0-75 wt% KTP, using five different amorphization techniques: melt quenching, rotary evaporation with vacuum drying, spray drying, and acoustic levitation with either a premixed solution or in situ mixing of separate co-sprayed solutions...
April 18, 2024: RSC Pharm
#4
Diane Ingabire, Chaolong Qin, Tuo Meng, Aji Alex Moothendathu Raynold, Hadi Sudarjat, E Andrew Townsend, Rudra Pangeni, Sagun Poudel, Michelle Arriaga, Long Zhao, Woon N Chow, Matthew Banks, Qingguo Xu
The treatment landscape for opioid use disorder (OUD) faces challenges stemming from the limited efficacy of existing medications, poor adherence to prescribed regimens, and a heightened risk of fatal overdose post-treatment cessation. Therefore, there is a pressing need for innovative therapeutic strategies that enhance the effectiveness of interventions and the overall well-being of individuals with OUD. This study explored the therapeutic potential of nor-Levo-α-acetylmethadol (nor-LAAM) to treat OUD...
April 11, 2024: bioRxiv
#5
JOURNAL ARTICLE
Daniel Encarnacion-Santos, Renat Nurmukhametov, Medet Donasov, Alexander Volovich, Ismail Bozkurt, Jack Wellington, Miguel Espinal-Lendof, Ismael Peralta, Bipin Chaurasia
BACKGROUND: One of the most frequent etiologies for spinal surgery is unstable lumbar spondylolisthesis (ULS). To decompress affected structures while maintaining or restoring stability through fusion, surgeons utilize a variety of procedures. When paired with interbody fusion, posterior fusion is most applied, resulting in greater fusion rates. The two most popular techniques for implementing spinal fusion are posterior lumbar interbody fusion (PLIF) and transforaminal lumbar interbody fusion (TLIF)...
2024: Journal of Craniovertebral Junction and Spine
#6
JOURNAL ARTICLE
Marie Abitbol, Alice Couronné, Caroline Dufaure de Citres, Vincent Gache
During the last 60 years many inherited traits in domestic outbred cats were selected and retained giving birth to new breeds characterised by singular coat or morphological phenotypes. Among them, minimal white spotting associated with blue eyes was selected by feline breeders to create the Altai, Topaz, and Celestial breeds. Various established breeds also introduced this trait in their lineages. The trait, that was confirmed as autosomal dominant by breeding data, was first described in domestic cats from Kazakhstan and Russia, in British shorthair and British longhair from Russia, and in Maine Coon cats from the Netherlands, suggesting different founding effects...
April 22, 2024: Animal Genetics
#7
JOURNAL ARTICLE
Anke Arkesteyn, Véronique Cornelissen, Jean Steyaert, Jomme Claes, Matthijs Michielsen, Tine Van Damme
PURPOSE: There is a need for valid and reliable clinical assessment tools to assess cardiorespiratory fitness (CRF) levels in adolescents with autism. Therefore, this study aimed to examine the concurrent validity and test-retest reliability of the Astrand-Rhyming Test (ART) in this population. MATERIALS AND METHODS: 45 adolescents with autism aged 12-18 years ( n = 32 males, 14.47 ± 1.79 years) performed the ART twice (test-retest reliability) and completed a maximal cardiopulmonary exercise test (CPET) (concurrent validity)...
April 21, 2024: Disability and Rehabilitation
#8
JOURNAL ARTICLE
Yue Lei, Xin Xu, Junying Yin, Kang Xi, Lai Wei, Junzi Zheng, Yuhao Wang, Haihua Wu, Sen Jiang, Yunfang Gao
LiPF6 -based carbonate electrolytes have been extensively employed in commercial Li-ion batteries, but they face numerous interfacial stability challenges while applicating in high-energy-density lithium-metal batteries (LMBs). Herein, this work proposes N-succinimidyl trifluoroacetate (NST) as a multifunctional electrolyte additive to address these challenges. NST additive could optimize Li+ solvation structure and eliminate HF/H2 O in the electrolyte, and preferentially be decomposed on the Ni-rich cathode (LiNi0...
April 21, 2024: Small
#9
JOURNAL ARTICLE
Manon Baudic, Hiroshige Murata, Fernanda M Bosada, Uirá Souto Melo, Takanori Aizawa, Pierre Lindenbaum, Lieve E van der Maarel, Amaury Guedon, Estelle Baron, Enora Fremy, Adrien Foucal, Taisuke Ishikawa, Hiroya Ushinohama, Sean J Jurgens, Seung Hoan Choi, Florence Kyndt, Solena Le Scouarnec, Vincent Wakker, Aurélie Thollet, Annabelle Rajalu, Tadashi Takaki, Seiko Ohno, Wataru Shimizu, Minoru Horie, Takeshi Kimura, Patrick T Ellinor, Florence Petit, Yves Dulac, Paul Bru, Anne Boland, Jean-François Deleuze, Richard Redon, Hervé Le Marec, Thierry Le Tourneau, Jean-Baptiste Gourraud, Yoshinori Yoshida, Naomasa Makita, Claude Vieyres, Takeru Makiyama, Stephan Mundlos, Vincent M Christoffels, Vincent Probst, Jean-Jacques Schott, Julien Barc
While 3D chromatin organization in topologically associating domains (TADs) and loops mediating regulatory element-promoter interactions is crucial for tissue-specific gene regulation, the extent of their involvement in human Mendelian disease is largely unknown. Here, we identify 7 families presenting a new cardiac entity associated with a heterozygous deletion of 2 CTCF binding sites on 4q25, inducing TAD fusion and chromatin conformation remodeling. The CTCF binding sites are located in a gene desert at 1 Mb from the Paired-like homeodomain transcription factor 2 gene (PITX2)...
April 20, 2024: Nature Communications
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JOURNAL ARTICLE
Akkarach Sukserm, Matteo Ceppatelli, Manuel Serrano-Ruiz, Demetrio Scelta, Kamil Dziubek, Marta Morana, Roberto Bini, Maurizio Peruzzini, Thiti Bovornratanaraks, Udomsilp Pinsook, Sandro Scandolo
The covalent bonding framework of crystalline single-bonded cubic AsN, recently synthesized under high pressure and high temperature conditions in a laser-heated diamond anvil cell, is here studied by means of density functional theory calculations and compared to single crystal X-ray diffraction data. The precise localization of the nonbonding electron lone pairs and the determination of their distances and orientations are related to the presence of characteristic structural motifs and space regions of the unit cell dominated by repulsive electronic interactions, with the relative orientation of the electron lone pairs playing a key role in minimizing the energy of the structure...
April 19, 2024: Inorganic Chemistry
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JOURNAL ARTICLE
Mohamed Ali Boujelbane, Khaled Trabelsi, Atef Salem, Achraf Ammar, Jordan M Glenn, Omar Boukhris, Maha M AlRashid, Haitham Jahrami, Hamdi Chtourou
BACKGROUND: Alzheimer's disease and mild cognitive impairment (MCI) progress silently, making early diagnosis challenging, especially in less educated populations. The visual paired comparison (VPC) task, utilizing eye-tracking movement (ETM) technology, offers a promising alternative for early detection of memory decline. OBJECTIVE: This systematic review and meta-analysis evaluated the efficacy of the VPC task, utilizing ETM as a tool for assessing age-related cognitive changes...
April 16, 2024: Journal of Alzheimer's Disease: JAD
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JOURNAL ARTICLE
Yuying Han, Zhenghong Yuan, Zhigang Yi
The coronavirus disease 2019 (COVID-19) pandemic, caused by the novel coronavirus severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), has rapidly spread worldwide since its emergence in late 2019. Its ongoing evolution poses challenges for antiviral drug development. Coronavirus nsp6, a multiple-spanning transmembrane protein, participates in the biogenesis of the viral replication complex, which accommodates the viral replication-transcription complex. The roles of its structural domains in viral replication are not well studied...
April 19, 2024: Journal of Virology
#13
JOURNAL ARTICLE
Sichao Li, Oliver S Hammond, Andrew Nelson, Liliana de Campo, Michael Moir, Carl Recsei, Manishkumar R Shimpi, Sergei Glavatskih, Georgia A Pilkington, Anja-Verena Mudring, Mark W Rutland
Three nonhalogenated ionic liquids (ILs) dissolved in 2-ethylhexyl laurate (2-EHL), a biodegradable oil, are investigated in terms of their bulk and electro-interfacial nanoscale structures using small-angle neutron scattering (SANS) and neutron reflectivity (NR). The ILs share the same trihexyl(tetradecyl)phosphonium ([P6,6,6,14 ]+ ) cation paired with different anions, bis(mandelato)borate ([BMB]- ), bis(oxalato)borate ([BOB]- ), and bis(salicylato)borate ([BScB]- ). SANS shows a high aspect ratio tubular self-assembly structure characterized by an IL core of alternating cations and anions with a 2-EHL-rich shell or corona in the bulk, the geometry of which depends upon the anion structure and concentration...
April 19, 2024: Journal of Physical Chemistry. B
#14
JOURNAL ARTICLE
Saman Naseri Boroujeni, B Maribo-Mogensen, X Liang, G M Kontogeorgis
In this study, we present a new equation of state for electrolyte solutions, integrating the statistical associating fluid theory for variable range interactions utilizing the generic Mie form and binding Debye-Hückel theories. This equation of state underscores the pivotal role of ion-ion association in determining the properties of electrolyte solutions. We propose a unified framework that simultaneously examines the thermodynamic properties of electrolyte solutions and their electrical conductivity, given the profound impact of ion pairing on this transport property...
April 21, 2024: Journal of Chemical Physics
#15
JOURNAL ARTICLE
Junwei Li, Hongshuai Yin, Sisi Liu, Chaofa Xu, Zhixiong Cai
The catalytic performance of a catalyst is significantly influenced by its ability to activate hydrogen. Constructing frustrated Lewis pairs (FLPs) with the capacity for hydrogen dissociation on non-reducible supports remains a formidable challenge. Herein, we employed a straightforward method to synthesize a layered AlOOH featuring abundant OH defects suitable for constructing solid surface frustrated Lewis pair (ssFLP). The results indicated that the AlOOH-80 (synthesized at 80 °C) possessed an appropriate crystalline structure conducive to generating numerous OH defects, which facilitated the formation of ssFLP...
April 16, 2024: RSC Advances
#16
JOURNAL ARTICLE
Chaowei Zhao
Objective: This study evaluated the outcome of a broad palisade cartilage graft in the repair of subtotal perforation. Study Design: Prospective case series. Materials and Methods: This was a prospective study of 43 patients with subtotal perforations who underwent an endoscopic broad palisade cartilage graft procedure that did not include raising a tympanomeatal flap. The patients were followed up for 6 months. Results: The 43 patients (43 ears) included in this study had a mean operation time of 38.6 ± 7...
April 18, 2024: Ear, Nose, & Throat Journal
#17
JOURNAL ARTICLE
Mufeng Xi, Xiaohu Zhang, Hong Liu, Bolin Xu, Yongliang Zheng, Yujie Du, Lin Yang, Sai Kishore Ravi
In the rapidly advancing semiconductor sector, thermal management of chips remains a pivotal concern. Inherent heat generation during their operation can lead to a range of issues such as potential thermal runaway, diminished lifespan, and current leakage. To mitigate these challenges, the study introduces a superhygroscopic hydrogel embedded with metal ions. Capitalizing on intrinsic coordination chemistry, the metallic ions in the hydrogel form robust coordination structures with non-metallic nitrogen and oxygen through empty electron orbitals and lone electron pairs...
April 18, 2024: Small Methods
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JOURNAL ARTICLE
Saeed Jerban, Dina Moazamian, Hamidreza Shaterian Mohammadi, Yajun Ma, Hyungseok Jang, Behnam Namiranian, Soo Hyun Shin, Salem Alenezi, Sameer B Shah, Christine B Chung, Eric Y Chang, Jiang Du
High-resolution magnetic resonance imaging (HR-MRI) has been increasingly used to assess the trabecular bone structure. High susceptibility at the marrow/bone interface may significantly reduce the marrow's apparent transverse relaxation time (T2*), overestimating trabecular bone thickness. Ultrashort echo time MRI (UTE-MRI) can minimize the signal loss caused by susceptibility-induced T2* shortening. However, UTE-MRI is sensitive to chemical shift artifacts, which manifest as spatial blurring and ringing artifacts partially due to non-Cartesian sampling...
April 15, 2024: Bone
#19
JOURNAL ARTICLE
Raktim Mitra, Ari S Cohen, Remo Rohs
Analyzing and visualizing the tertiary structure and complex interactions of RNA is essential for being able to mechanistically decipher their molecular functions in vivo. Secondary structure visualization software can portray many aspects of RNA; however, these layouts are often unable to preserve topological correspondence since they do not consider tertiary interactions between different regions of an RNA molecule. Likewise, quaternary interactions between two or more interacting RNA molecules are not considered in secondary structure visualization tools...
April 17, 2024: Nucleic Acids Research
#20
JOURNAL ARTICLE
Johannes Schetelig, Henning Baldauf, Falk Heidenreich, Jorinde D Hoogenboom, Stephen R Spellman, Alexander Kulagin, Thomas Schroeder, Henrik Sengeloev, Peter Dreger, Edouard Forcade, Jan Vydra, Eva Maria Wagner-Drouet, Goda Choi, Shankara Paneesha, Nuno A A Miranda, Alina Tanase, Liesbeth C de Wreede, Vinzenz Lange, Alexander H Schmidt, Jürgen Sauter, Joshua A Fein, Yung-Tsi Bolon, Meilun He, Steven G E Marsh, Shahinaz M Gadalla, Sophie Paczesny, Annalisa Ruggeri, Christian Chabannon, Katharina Fleischhauer
Optimizing natural killer (NK) cell alloreactivity could further improve outcome after allogeneic hematopoietic cell transplantation (alloHCT). The donor's Killer-cell Immunoglobulin-like Receptor (KIR) genotype may provide important information in this regard. In the past decade, different models have been proposed aiming at maximizing NK cell activation by activating KIR-ligand interactions or minimizing inhibitory KIR-ligand interactions. Alternative classifications intended predicting outcome after alloHCT by donor KIR-haplotypes...
2024: Frontiers in Immunology
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