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https://www.readbyqxmd.com/read/28738600/quantification-of-intercellular-adhesion-forces-measured-by-fluid-force-microscopy
#1
Noa Cohen, Saheli Sarkar, Evangelia Hondroulis, Pooja Sabhachandani, Tania Konry
The mechanics of cancer cell adhesion to its neighboring cells, homotypic or heterotypic, have significant impact on tumor progression and metastasis. Intercellular adhesion has been quantified previously using atomic force microscopy-based methods. Here we show the feasibility of the recently developed fluidic force microscopy (FluidFM) to measure adhesive forces exerted by breast cancer cells. Multiple cell pairs were assessed at precisely controlled, increasing contact durations by pressure-dependent immobilization of a cell at the probe tip...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28735015/preliminary-experience-of-non-transecting-urethroplasty-for-pelvic-fracture-related-urethral-injury
#2
Hong Xie, Chao Li, Yue-Min Xu, Chao Feng, Xiang-Guo Lv, Lei Chen, Hong-Bin Li, Jing-Dong Xue
OBJECTIVE: To evaluate the urinary outcomes and preservation of erectile function in patients with pelvic fracture related urethral injury (PFUI) after non-transecting spongiosum anastomotic urethroplasty (NTSAU). METHODS: Fifty-nine male patients with PFUI following traumatic pelvic fracture underwent NTSAU. Inclusion criteria were age 18 to 60 years, posterior urethral stenosis < 2.5 cm without previous urethroplasty, and intact erectile function. Exclusion criteria were previous history of open urethroplasty, long segment posterior urethral stenosis (>2...
July 19, 2017: Urology
https://www.readbyqxmd.com/read/28732215/a-method-for-next-generation-sequencing-of-paired-diagnostic-and-remission-samples-to-detect-mitochondrial-dna-mutations-associated-with-leukemia
#3
Ilaria S Pagani, Chung H Kok, Verity A Saunders, Mark B Van der Hoek, Susan L Heatley, Anthony P Schwarer, Christopher N Hahn, Timothy P Hughes, Deborah L White, David M Ross
Somatic mitochondrial DNA (mtDNA) mutations have been identified in many human cancers, including leukemia. To identify somatic mutations, it is necessary to have a control tissue from the same individual for comparison. When patients with leukemia achieve remission, the remission peripheral blood may be a suitable and easily accessible control tissue, but this approach has not previously been applied to the study of mtDNA mutations. We have developed and validated a next-generation sequencing approach for the identification of leukemia-associated mtDNA mutations in 26 chronic myeloid leukemia patients at diagnosis using either nonhematopoietic or remission blood samples as the control...
July 18, 2017: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/28732156/fixed-bed-modeling-of-nonsteroidal-anti-inflammatory-drug-removal-by-ion-exchange-in-synthetic-urine-mass-removal-or-toxicity-reduction
#4
Kelly Ann Landry, Treavor H Boyer
Ion-exchange removal of nonsteroidal anti-inflammatory drugs (NSAIDs) in synthetic urine can selectively remove pharmaceuticals with minimal co-removal of nutrients to enhance nutrient recovery efforts. However, the effect of endogenous metabolites in urine on ion-exchange removal, and the corresponding reduction in ecotoxicity potential of pharmaceuticals in treated urine entering the environment, is unknown. To assess treatment efficacy, this work paired predicted breakthrough curves determined by the homogenous surface diffusion model to an in vitro bioassay to evaluate COX-1 inhibition...
July 21, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28731701/a-model-for-the-enantioselectivity-of-asymmetric-intramolecular-alkylations-by-bis-quaternized-cinchona-alkaloid-derived-catalysts
#5
Cyndi Qixin He, Adam Simon, Yu-Hong Lam, Andrew P J Brunskill, Nobuyoshi Yasuda, Jiajing Tan, Alan M Hyde, Edward C Sherer, Kendall N Houk
A model for the stereoselectivity of intramolecular alkylations by N,N'-disubstituted cinchona alkaloids reported by Xiang et al. was established using density functional theory (DFT) calculations. The stereocontrol is based on the minimal distortion of the TS and catalyst required to achieve favorable electrostatic interactions in the favored TS. Counterions must be included in computational modeling of ion-paired catalysis in order to reproduce experimental enantioselectivity.
July 21, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28730929/development-of-a-screening-tool-to-predict-malnutrition-among-children-under-two-years-old-in-zambia
#6
Junko Hasegawa, Yoichi M Ito, Taro Yamauchi
BACKGROUND: Maternal and child undernutrition is an important issue, particularly in low- and middle-income countries. Children at high risk of malnutrition should be prioritized to receive necessary interventions to minimize such risk. Several risk factors have been proposed; however, until now, there has been no appropriate evaluation method to identify these children. In sub-Saharan Africa, children commonly receive regular check-ups from community health workers. A simple and easy nutrition assessment method is therefore needed for use by semi-professional health workers...
2017: Global Health Action
https://www.readbyqxmd.com/read/28730541/increased-sequencing-depth-does-not-increase-captured-diversity-of-arbuscular-mycorrhizal-fungi
#7
Martti Vasar, Reidar Andreson, John Davison, Teele Jairus, Mari Moora, Maido Remm, J P W Young, Martin Zobel, Maarja Öpik
The arrival of 454 sequencing represented a major breakthrough by allowing deeper sequencing of environmental samples than was possible with existing Sanger approaches. Illumina MiSeq provides a further increase in sequencing depth but shorter read length compared with 454 sequencing. We explored whether Illumina sequencing improves estimates of arbuscular mycorrhizal (AM) fungal richness in plant root samples, compared with 454 sequencing. We identified AM fungi in root samples by sequencing amplicons of the SSU rRNA gene with 454 and Illumina MiSeq paired-end sequencing...
July 20, 2017: Mycorrhiza
https://www.readbyqxmd.com/read/28729847/effects-of-intensive-crew-training-on-individual-and-collective-characteristics-of-oar-movement-in-rowing-as-a-coxless-pair
#8
Mathieu Feigean, Mehdi R'Kiouak, Reinoud J Bootsma, Jérôme Bourbousson
This case study examined how two rowers adapted their rowing patterns following crew training as a newly formed coxless pair. The two participants were expert (double-oar) single scull-boat rowers. Performing as a crew in the coxless-pair's sweep-boat, where each rower operates a single oar, on-the-water data were collected before and after a 6-week intensive team-training program. Rowing patterns were characterized by the horizontal oar angle, oar angular velocity and linear oar-water velocity profiles during the catch (minimal oar angle) to finish (maximal oar angle) half-cycles of the propulsive water phase...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28728601/transabdominal-laparoscopic-retroperitoneal-neurectomy-for-chronic-pain-after-inguinal-hernia-repair-and-appendicectomy-a-matched-pair-study
#9
Ioannis Karampinis, Johannes Weiss, Lothar Pilz, Stefan Post, Florian Herrle
BACKGROUND: Chronic debilitating pain is a rare but significant cause of postoperative morbidity after inguinal surgery. Such pain is usually of neuropathic origin and frequently caused by intraoperative nerve damage. In this retrospective matched-pair study we analysed results of a minimal-invasive approach to neurectomy on quality of life and pain relief. METHODS: From March 2010 to January 2012, 9 patients developing chronic neuropathic pain after inguinal hernia repair (8 patients) or open appendicectomy (one patient) were operated using a laparoscopic transabdominal approach in our department...
July 20, 2017: BMC Surgery
https://www.readbyqxmd.com/read/28727713/local-brain-activity-differences-between-herpes-zoster-and-postherpetic-neuralgia-patients-a-resting-state-functional-mri-study
#10
Song Cao, Ying Li, Wenwen Deng, Bangyong Qin, Yi Zhang, Peng Xie, Jie Yuan, Buwei Yu, Tian Yu
BACKGROUND: Herpes zoster (HZ) can develop into postherpetic neuralgia (PHN), both of which are painful diseases. PHN patients suffer chronic pain and emotional disorders. Previous studies showed that the PHN brain displayed abnormal activity and structural change, but the difference in brain activity between HZ and PHN is still not known. OBJECTIVES: To identify regional brain activity changes in HZ and PHN brains with resting-state functional magnetic resonance imaging (rs-fMRI) technique, and to observe the differences between HZ and PHN patients...
July 2017: Pain Physician
https://www.readbyqxmd.com/read/28724485/effects-of-breeding-configuration-on-maternal-and-weanling-behavior-in-laboratory-mice
#11
Gillian C Braden, Skye Rasmussen, Sebastien Monette, Ravi J Tolwani
Although numerous studies have evaluated the effect of housing density on the wellbeing of laboratory mice, little is known about the effect of breeding configuration on mouse behavior. The 8th edition of the Guide for the Care and Use of Laboratory Animals lists the recommended minimal floor area per animal for a female mouse and her litter as 51 in.2 We sought to determine the effects of pair, trio, and harem breeding configurations on the maternal and weanling behavior of C57BL/6J (B6) and 129S6/SvEvTac (129) mice on the basis of nest scores and performance in pup retrieval tests, open-field test (OFT), elevated plus maze, and tail suspension test; we concurrently evaluated cage microenvironment, reproductive indices, and anatomic and clinical pathology...
July 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28717289/comparison-of-extended-nasolabial-flap-versus-buccal-fat-pad-graft-in-the-surgical-management-of-oral-submucous-fibrosis-a-prospective-pilot-study
#12
Sandeep B Patil, D Durairaj, G Suresh Kumar, D Karthikeyan, D Pradeep
AIM: To evaluate the application of extended nasolabial flap versus buccal fat pad graft in the surgical management of oral submucous fibrosis. SETTINGS AND DESIGN: This prospective study was carried out in the Department of Oral and Maxillofacial Surgery, Tamil Nadu Government Dental College and Hospital, Chennai. MATERIAL AND METHODS: A total of 8 patients (6 men and 2 women) with age range from 21 to 65 years were selected for study. These 8 patients were randomly divided into two groups of four namely group 1 and group 2...
September 2017: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/28713227/design-of-3-d-printed-concentric-tube-robots
#13
Tania K Morimoto, Allison M Okamura
Concentric tube surgical robots are minimally invasive devices with the advantages of snake-like reconfigurability, long and thin form factor, and placement of actuation outside the patient's body. These robots can also be designed and manufactured to acquire targets in specific patients for treating specific diseases in a manner that minimizes invasiveness. We propose that concentric tube robots can be manufactured using 3-D printing technology on a patient- and procedure-specific basis. In this paper, we define the design requirements and manufacturing constraints for 3-D printed concentric tube robots and experimentally demonstrate the capabilities of these robots...
December 2016: IEEE Transactions on Robotics: a Publication of the IEEE Robotics and Automation Society
https://www.readbyqxmd.com/read/28712896/prospective-evaluation-of-the-non-invasive-headsense-icp-monitor-in-tbi-patients-undergoing-invasive-icp-monitoring
#14
Martin W Herklots, Walid Moudrous, Annemarie Oldenbeuving, Gerwin Roks, Stylianos Mourtzoukos, Guus G Schoonman, Oliver Ganslandt
BACKGROUND: Currently intracranial pressure (ICP) is measured by invasive methods with a significant risk of infectious and hemorrhagic complications. Because of these high risks, there is need for a noninvasive ICP (nICP) monitor with an accuracy similar to that of an invasive ICP monitor. OBJECTIVE: To assess prospectively the accuracy and precision of a nICP monitor compared with invasive intracranial pressure (iICP) measurement in severe TBI patients. METHODS: Participants were ICP-monitored patients who had sustained TBI...
July 13, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28712580/single-dose-del-nido-cardioplegia-in-minimally-invasive-aortic-valve-surgery
#15
Daniel Ziazadeh, Regina Mater, Ben Himelhoch, Andrew Borgman, Jessica L Parker, Charles L Willekes, Tomasz A Timek
BACKGROUND: The del Nido cardioplegia (DC) procedure offers prolonged cardiac protection with single-dose administration and has proven safe in adult coronary artery bypass grafting (CABG) surgery. We set out to evaluate the efficacy of cardiac protection and clinical outcomes of DC versus standard blood cardioplegia (BC) in minimally invasive aortic valve surgery. METHODS: Between August 2011 and May 2016, 178 patients underwent minimally invasive aortic valve replacement (AVR) with BC (n = 101) or DC (n = 77)...
June 12, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28712172/laparoscopic-sleeve-gastrectomy-a-prospective-follow-up-of-30-patients
#16
Asad Ali Toor, Muhammad Waris Farooka, Mahmood Ayyaz, Zeeshan Razzaq, Awais Amjad Malik, Allah Nawaz, Asif Mahmood, Henry Paul Redmond
BACKGROUND: Morbid obesity has become a surgically treatable problem. Laparoscopic sleeve gastrectomy is becoming a popular choice both for surgeons and patients due to effectiveness and low complication rates. METHODS: It was a prospective case series spanning over 6 years. Patient enrolment started from January 2009 and data collection completed in January 2015. Patient with BMI (weight in kilogram/height in meter square) of more than 35 were included in the study...
January 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28711348/impact-of-molecular-flexibility-on-the-site-energy-shift-of-chlorophylls-in-photosystem-ii
#17
Daniele Narzi, Emanuele Coccia, Marco Manzoli, Leonardo Guidoni
Light harvesting from the Sun by antenna complexes surrounding the reaction center of Photosystem II represents the first step of the natural oxygenic photosynthesis performed by plants, algae and cyanobacteria. The excitation energy derived from the sunlight is absorbed by the chlorophylls of the antenna and subsequently conveyed to the reaction center of Photosystem II through resonant energy transfer mechanisms. In the special pair of chlorophylls of the reaction center the charge separation occurs, eventually leading to the oxidation of water molecules into protons, electrons and molecular oxygen...
July 8, 2017: Biophysical Chemistry
https://www.readbyqxmd.com/read/28709318/curvature-controlled-defect-dynamics-in-active-systems
#18
Sebastian Ehrig, Jonathan Ferracci, Richard Weinkamer, John W C Dunlop
We have studied the collective motion of polar active particles confined to ellipsoidal surfaces. The geometric constraints lead to the formation of vortices that encircle surface points of constant curvature (umbilics). We have found that collective motion patterns are particularly rich on ellipsoids with four umbilics where vortices tend to be located near pairs of umbilical points to minimize their interaction energy. Our results provide a perspective on the migration of living cells, which most likely use the information provided from the curved substrate geometry to guide their collective motion...
June 2017: Physical Review. E
https://www.readbyqxmd.com/read/28708548/predicting-locations-of-high-risk-plaques-in-coronary-arteries-in-patients-receiving-statin-therapy
#19
Ling Zhang, Andreas Wahle, Zhi Chen, John J Lopez, Tomas Kovarnik, Milan Sonka
Features of high-risk coronary artery plaques prone to major adverse cardiac events (MACE) were identified by intravascular ultrasound (IVUS) virtual histology (VH). These plaque features are: Thin-cap fibroatheroma (TCFA), plaque burden PB≥70%, or minimal luminal area MLA≤4mm². Identification of arterial locations likely to later develop such high-risk plaques may help prevent MACE. We report a machine learning method for prediction of future high-risk coronary plaque locations and types in patients under statin therapy...
July 11, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28707988/first-clinical-report-of-helical-tomotherapy-with-simultaneous-integrated-boost-for-synchronous-bilateral-breast-cancer
#20
Tabassum Wadasadawala, Shanu Jain, Siji Paul, Reena Phurailatpam, Kishore Joshi, Palak Popat, Sandip Tandon, Aruna Alahari, Rajiv Sarin
OBJECTIVE: Radiotherapy for synchronous bilateral breast cancer (SBBC) is technically very challenging. This study reports the clinical feasibility, dosimetry and safety of helical tomotherapy (HT) with simultaneous integrated boost (SIB) in patients treated with adjuvant radiotherapy for SBBC. MATERIAL AND METHODS: Twenty one women with SBBC treated with HT from January 2013 to June 2016 were retrospectively evaluated. Radiation lung toxicity was assessed using pulmonary function test (PFT) and high resolution computerized tomography scan (HRCT) scan at baseline and 1 year post RT in 18 patients...
July 14, 2017: British Journal of Radiology
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