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https://www.readbyqxmd.com/read/28433220/comparison-of-two-minimally-invasive-techniques-and-median-sternotomy-in-aortic-valve-replacement
#1
Severin Semsroth, Raffaela Matteucci Gothe, Yvonne Rodríguez Raith, Kristof de Brabandere, Esther Hanspeter, Juliane Kilo, Markus Kofler, Ludwig Müller, Elfriede Ruttman-Ulmer, Michael Grimm
BACKGROUND: Propensity score-matched analysis of the anterolateral minithoracotomy and the partial upper hemisternotomy vs the median sternotomy approach has not been reported to date for isolated aortic valve replacement. METHODS: From 2005 to 2013, isolated aortic valve replacement was performed through a partial upper hemisternotomy in 315 patients (38.9%), through a median sternotomy in 328 patients (40.5%), and through an anterolateral minithoracotomy in 167 patients (20...
April 19, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28426993/a-new-combined-method-of-stable-isotope-labeling-derivatization-ultrasound-assisted-dispersive-liquid-liquid-microextraction-for-the-determination-of-neurotransmitters-in-rat-brain-microdialysates-by-ultra-high-performance-liquid-chromatography-tandem-mass
#2
Longfang Zheng, Xian-En Zhao, Shuyun Zhu, Yanduo Tao, Wenhua Ji, Yanling Geng, Xiao Wang, Guang Chen, Jinmao You
In this work, for the first time, a new hyphenated technique of stable isotope-labeling derivatization-ultrasound-assisted dispersive liquid-liquid microextraction has been developed for the simultaneous determination of monoamine neurotransmitters (MANTs) and their biosynthesis precursors and metabolites. The developed method was based on ultra high performance liquid chromatography tandem mass spectrometry detection using multiple-reaction monitoring mode. A pair of mass spectrometry sensitizing reagents, d0-10-methyl-acridone-2-sulfonyl chloride and d3-10-methyl-acridone-2-sulfonyl chloride, as stable isotope probes was utilized to facilely label neurotransmitters, respectively...
April 10, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28424921/evolution-of-psychological-condition-in-caregivers-of-patients-with-disorders-of-consciousness-a-longitudinal-study
#3
Francesco Corallo, Lilla Bonanno, Viviana Lo Buono, Simona De Salvo, Cettina Allone, Rosanna Palmeri, Elena La Gattuta, Carmela Rifici, Antonella Alagna, Antonino Todaro, Placido Bramanti, Silvia Marino
The aim of this study is to evaluate mood disorders and needs in caregivers of disorders of consciousness (DOC) patients during the admission to Neurorehabilitation Unit. A total of 80 caregivers was enrolled and divided in two groups (caregivers of vegetative state-VS patients and caregivers of minimally conscious state-MCS patients). Paired sample t tests were carried out to test differences between baseline observation (T0) and after 6 months (T1). Caregivers of VS patients showed an improvement between T0 and T1 especially, in vitality, mean health, Beck Depression Inventory (BDI-II), Spielberger State-Trait Anxiety Inventory-Y (STAI-Y), Prolonged Grief Disorder (PG 12) and Caregiver Needs Assessment (CNA)...
April 19, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28423138/intimate-partner-violence-and-maternal-educational-practice
#4
Josianne Maria Mattos da Silva, Marília de Carvalho Lima, Ana Bernarda Ludermir
OBJECTIVE: The objective of this study is to analyze the association between intimate partner violence against women and maternal educational practice directed to children at the beginning of formal education. METHODS: This is a cross-sectional study, carried out between 2013 and 2014, with 631 mother/child pairs, registered in the Family Health Strategy of the Health District II of the city of Recife, State of Pernambuco, Brazil. It integrates a prospective cohort study designed to investigate the consequences of exposure to intimate partner violence in relation to the child who was born between 2005 and 2006...
April 10, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/28421848/an-evaluation-of-a-community-oriented-policing-program-in-taiwan
#5
Shih-Ya Kuo, Yuan-Chin Shih
This study was conducted to evaluate the effect of a community-oriented policing (COP) by documenting results for 16 quantitative outcome variables, including crime incidents, crime clearance, residents' subjective feelings regarding police performance and community safety, and job satisfaction among police officers. The statistical techniques used to analyze the data involved ARIMA interrupted time series, t tests, the Wilcoxon paired signed-rank test, and Pearson's correlation. The quantitative results observed indicated that the program had a positive effect on resident's perceptions for some police performance outcomes and for job satisfaction among police officers...
April 1, 2017: International Journal of Offender Therapy and Comparative Criminology
https://www.readbyqxmd.com/read/28420326/transcriptional-changes-induced-by-bevacizumab-combination-therapy-in-responding-and-non-responding-recurrent-glioblastoma-patients
#6
Thomas Urup, Line Mærsk Staunstrup, Signe Regner Michaelsen, Kristoffer Vitting-Seerup, Marc Bennedbæk, Anders Toft, Lars Rønn Olsen, Lars Jønson, Shohreh Issazadeh-Navikas, Helle Broholm, Petra Hamerlik, Hans Skovgaard Poulsen, Ulrik Lassen
BACKGROUND: Bevacizumab combined with chemotherapy produces clinical durable response in 25-30% of recurrent glioblastoma patients. This group of patients has shown improved survival and quality of life. The aim of this study was to investigate changes in gene expression associated with response and resistance to bevacizumab combination therapy. METHODS: Recurrent glioblastoma patients who had biomarker-accessible tumor tissue surgically removed both before bevacizumab treatment and at time of progression were included...
April 18, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28419517/comparative-analysis-between-rq-pcr-and-digital-droplet-pcr-of-bcl2-igh-gene-rearrangement-in-the-peripheral-blood-and-bone-marrow-of-early-stage-follicular-lymphoma
#7
Marzia Cavalli, Lucia Anna De Novi, Irene Della Starza, Luca Vincenzo Cappelli, Vittorio Nunes, Alessandro Pulsoni, Ilaria Del Giudice, Anna Guarini, Robin Foà
BCL2/IGH rearrangements were analysed by polymerase chain reaction (PCR) at diagnosis in paired peripheral blood (PB) and bone marrow (BM) samples from 67 patients with stage I/II follicular lymphoma (FL). Real time quantitative PCR (RQ-PCR) and digital droplet PCR (ddPCR) were performed in cases with a major breakpoint region (MBR+) at diagnosis and after localized radiotherapy and rituximab administration in order to investigate the applicability of ddPCR. The overall ddPCR/RQ-PCR concordance was 81·9% (113/138 samples) and 97·5% in the 40/138 with quantifiable disease (RQ-PCR≥10(-5) )...
April 17, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28419272/insecticidal-and-behavioral-avoidance-responses-of-anopheles-minimus-and-culex-quinquefasciatus-diptera-culicidae-to-three-synthetic-repellents
#8
Wasana Boonyuan, Sunaiyana Sathantriphop, Krajana Tainchum, Vithee Muenworn, Atchariya Prabaripai, Michael J Bangs, Theeraphap Chareonviriyaphap
Escape responses, knockdown (KD), and toxicity of laboratory strains of Anopheles minimus Theobald and Culex quinquefasciatus Say to three synthetic mosquito repellents, DEET (N, N-diethyl-3-methylbenzamide), IR3535, or picaridin, at 5% v/v concentrations, were evaluated using repellent-treated papers in standard WHO tube assays and an excito-repellency (ER) test chamber system. The tube assays recorded knockdown effects of each repellent immediately after 30-min exposure and the final morality following a 24-h holding period...
April 15, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/28418784/a-fresh-cadaver-model-for-the-instruction-of-ultrasound-guided-fine-needle-aspiration-of-thyroid-nodules
#9
Hilary C McCrary, Erynne A Faucett, Audriana N Hurbon, Tijana Milinic, Jose A Cervantes, Sean L Kent, William J Adamas-Rappaport
Objective The aim of our study is to determine if a fresh cadaver model (FCM) for the instruction of ultrasound (US)-guided fine-needle aspiration (FNA) of thyroid nodules is a practical method for instruction. Study Design Pre- and postinstruction assessment of medical students' ability to perform US-guided FNA of artificially created thyroid nodules placed adjacent to the thyroid gland of a fresh cadaver. Setting University-based fresh cadaver laboratory. Subjects and Methods Study participants included a total of 17 first- and second-year medical students with minimal US training...
April 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28412050/-the-correlation-among-the-ramsay-sedation-scale-richmond-agitation-sedation-scale-and-riker-sedation-agitation-scale-during-midazolam-remifentanil-sedation
#10
Turgut Namigar, Karacalar Serap, Akdaş Tekin Esra, Odacılar Özgül, Öztürk Ali Can, Ak Aysel, Ali Achmet
BACKGROUND AND OBJECTIVES: Sedative and analgesic treatment administered to critically ill patients need to be regularly assessed to ensure that previously stated goals are well achieved as the risk of complications of oversedation is minimized. We revised and prospectively tested the Ramsay Sedation Scale (RSS) for interrater reliability and compared it with the Riker Sedation-Agitation Scale (RSAS) and the Richmond Agitation Sedation Scale (RASS) to test construct validity during midazolam-remifentanil sedation...
April 12, 2017: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/28410096/leave-one-out-kernel-optimization-for-shadow-detection-and-removal
#11
Tomas F Yago Vicente, Minh Hoai, Dimitris Samaras
The objective of this work is to detect shadows in images. We pose this as the problem of labeling image regions, where each region corresponds to a group of superpixels. To predict the label of each region, we train a kernel Least-Squares Support Vector Machine(LSSVM) for separating shadow and non-shadow regions. The parameters of the kernel and the classifier are jointly learned to minimize the leave-one-out cross validation error. Optimizing the leave-one-out cross validation error is typically difficult, but it can be done efficiently in our framework...
April 6, 2017: IEEE Transactions on Pattern Analysis and Machine Intelligence
https://www.readbyqxmd.com/read/28408155/arthroscopic-capsular-plication-and-labral-seal-restoration-in-borderline-hip-dysplasia-2-year-clinical-outcomes-in-55-cases
#12
Sivashankar Chandrasekaran, Nader Darwish, Timothy J Martin, Carlos Suarez-Ahedo, Parth Lodhia, Benjamin G Domb
PURPOSE: To report clinical outcomes in patients with borderline dysplasia undergoing an arthroscopic technique of labral seal restoration with minimal acetabular rim resection and capsular plication. METHODS: Patients younger than 40 years with a lateral center-edge angle of 18° greater and 25° or less and 2-year follow-up after undergoing an arthroscopic technique of labral seal restoration with minimal rim resection (≤2 mm) and capsular plication (3-5 sutures placed in an oblique orientation to create an imbrication and inferior shift) were included...
April 10, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28408037/reduced-anxiety-and-depression-in-patients-with-advanced-heart-failure-after-left-ventricular-assist-device-implantation
#13
Gardner Yost, Geetha Bhat, Edward Mahoney, Antone Tatooles
BACKGROUND: Despite the high prevalence of depression and anxiety in patients with advanced heart failure, the effects of left ventricular assist device (LVAD) implantation on these critically important aspects of mental health are not well understood. OBJECTIVE: We sought to assess changes in depression and anxiety following LVAD implantation. METHODS: The Beck Depression Inventory-II (BDI-II) and Beck Anxiety Inventory (BAI) were administered to 54 patients by a clinical psychologist at a mean of 12 days before LVAD implantation and 251 days after implantation...
February 12, 2017: Psychosomatics
https://www.readbyqxmd.com/read/28404949/metabolomics-uncovers-a-link-between-inositol-metabolism-and-osteosarcoma-metastasis
#14
Ling Ren, Ellen S Hong, Arnulfo Mendoza, Sameer Issaq, Christine Tran Hoang, Michael Lizardo, Amy LeBlanc, Chand Khanna
Cancer development and progression are characterized by complex molecular events. The acquisition of these events is primarily believed to result from alterations in gene and protein expression/function. Recent studies have also suggested the role of metabolic alterations, or "metabolic reprogramming," that may similarly contribute to these events. Indeed, our previous investigations in osteosarcoma (OS) identified metabolic changes uniquely linked to metastasis. Based on those findings, here we sought to build a more detailed understanding of the specific alterations in metabolites or metabolic pathways that may be responsible for the observed metastasis-associated metabolic alterations, suggested by gene expression data...
March 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28404782/signatures-of-optimal-control-in-pairs-of-schooling-zebrafish
#15
Andress Laan, Raul Gil de Sagredo, Gonzalo G de Polavieja
Animals moving in groups coordinate their motion to remain cohesive. A large amount of data and analysis of movement coordination has been obtained in several species, but we are lacking theoretical frameworks that can derive the form of coordination rules. Here, we examine whether optimal control theory can predict the rules underlying social interactions from first principles. We find that a control rule which is designed to minimize the time it would take a pair of schooling fish to form a cohesively moving unit correctly predicts the characteristics of social interactions in fish...
April 12, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28394255/twist-stretch-profiles-of-dna-chains
#16
Marco Zoli
Helical molecules change their twist number under the effect of a mechanical load. We study the twist-stretch relation for a set of short DNA molecules modeled by a mesoscopic Hamiltonian. Finite temperature path integral techniques are applied to generate a large ensemble of possible configurations for the base pairs of the sequence. The model also accounts for the bending and twisting fluctuations between adjacent base pairs along the molecules stack. Simulating a broad range of twisting conformation, we compute the helix structural parameters by averaging over the ensemble of base pairs configurations...
April 10, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28393943/enhancing-coupled-enzymatic-activity-by-conjugating-one-enzyme-to-a-nanoparticle
#17
James N Vranish, Mario G Ancona, Eunkeu Oh, Kimihiro Susumu, Igor L Medintz
Enzymes have long been a prime research target for the commercial production of commodity and specialty chemicals, design of sensing devices, and the development of therapeutics and new chemical processes. Industrial applications for enzymes can potentially be enhanced by enzyme immobilization which often allows for increased enzyme stability, facile product purification, and minimized substrate diffusion times in multienzymatic cascades, but this is usually at the cost of a significant decrease in catalytic rates...
April 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/28393624/favored-and-less-favored-codon-anticodon-duplexes-arising-from-the-gc-codon-family-box-encoding-for-alanine-some-computational-perspectives
#18
Martina Devi, R H Duncan Lyngdoh
Alanine is encoded by the four codons of the GC box (GCA, GCG, GCU, and GCC). Known alanine anticodons include the UGC, IGC, and VGC triplets (I = inosine; V = uridine-5-oxyacetic acid). The energy-minimized structures of all possible codon-anticodon combinations involving all the alanine codons GCA, GCG, GCU, and GCC with the alanine anticodons UGC, IGC, and VGC are studied using the AMBER software. Fifteen H-bonded duplex structures arising out of these combinations are studied here, all having Watson-Crick-type base pairs at the first and second codon positions, and a variety of base pairing possibilities at the third (or wobble) position...
April 10, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28392350/choosing-the-right-fluorophore-for-single-molecule-fluorescence-studies-in-a-lipid-environment
#19
Zhenfu Zhang, Dan Yomo, Claudiu Gradinaru
Nonspecific interactions between lipids and fluorophores can alter the outcomes of single-molecule spectroscopy of membrane proteins in live cells, liposomes or lipid nanodiscs and of cytosolic proteins encapsulated in liposomes or tethered to supported lipid bilayers. To gain insight into these effects, we examined interactions between 9 dyes that are commonly used as labels for single-molecule fluorescence (SMF) and 6 standard lipids including cationic, zwitterionic and anionic types. The diffusion coefficients of dyes in the absence and presence of set amounts of lipid vesicles were measured by fluorescence correlation spectroscopy (FCS)...
April 6, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28391278/a-comparison-of-remote-and-bedside-assessment-of-the-national-institute-of-health-stroke-scale-in-acute-stroke-patients
#20
Andrey M Alasheev, Aleksey Y Andreev, Yuliya V Gonysheva, Maria N Lagutenko, Olga Y Lutskovich, Antonina V Mamonova, Elena V Prazdnichkova, Andrey A Belkin
INTRODUCTION: Telestroke videoconference for conducting the National Institute of Health Stroke Scale (NIHSS) is recommended when the facility of a direct bedside evaluation by a stroke specialist is not immediately available for hyperacute stroke assessment. However, some NIHSS-telestroke studies inherit systematic bias due to the subjective nature of NIHSS administration. We aimed to evaluate NIHSS telestroke assessment, while implementing measures to minimize subjectivity bias. PATIENTS AND METHODS: Ninety stroke patients within 48 h of onset were assessed by 6 stroke neurologists grouped in 15 pairs...
April 8, 2017: European Neurology
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