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https://www.readbyqxmd.com/read/29076486/-complications-of-the-open-surgeries-for-severe-acute-pancreatitis
#1
V P Glabay, O V Cridnev, A V Arkharov, A N Bykov, I A Kaprin, B G Muslimov
INTRODUCTION: With the unsuccessfulness of an intensive therapy and minimally invasive interventions in severe acute pancreatitis they resort to the 'open' surgical interventions. It is important to know about the classification of complications of such surgeries, the frequency of occurrences, the recognition peculiarities and the determination of a treatment plan for the practical surgery. AIM: The optimization of the usage of 'open' surgeries for patients with severe acute pancreatitis...
2017: Khirurgiia
https://www.readbyqxmd.com/read/29024292/hepatic-cystic-echinococcosis-in-australia-an-update-on-diagnosis-and-management
#2
REVIEW
Ben Keong, Bruce Wilkie, Tom Sutherland, Adrian Fox
BACKGROUND: Echinococcosis is an uncommonly encountered zoonotic disease caused by the taeniid Echinococcus. The only endemic species in Australia, Echinococcus granulosus, forms cysts in the liver in 70% of cases. The aim of this study was to review the literature to provide an evidence-based narrative update on the diagnosis and management of hepatic cystic echinococcosis in Australia. METHODS: We reviewed the literature, utilizing multiple research databases and citation tracking...
October 11, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28960310/novel-targets-for-sensitizing-breast-cancer-cells-to-trail-induced-apoptosis-with-sirna-delivery
#3
Bindu Thapa, Remant Bahadur Kc, Hasan Uludağ
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in variety of cancer cells without affecting most normal cells, which makes it a promising agent for cancer therapy. However, TRAIL therapy is clinically not effective due to resistance induction. To identify novel regulators of TRAIL that can aid in therapy, protein targets whose silencing sensitized breast cancer cells against TRAIL were screened with an siRNA library against 446 human apoptosis-related proteins in MDA-231 cells...
September 27, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28928645/auditory-motor-mapping-training-in-a-more-verbal-child-with-autism
#4
Karen V Chenausky, Andrea C Norton, Gottfried Schlaug
We tested the effect of Auditory-Motor Mapping Training (AMMT), a novel, intonation-based treatment for spoken language originally developed for minimally verbal (MV) children with autism, on a more-verbal child with autism. We compared this child's performance after 25 therapy sessions with that of: (1) a child matched on age, autism severity, and expressive language level who received 25 sessions of a non-intonation-based control treatment Speech Repetition Therapy (SRT); and (2) a matched pair of MV children (one of whom received AMMT; the other, SRT)...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28886205/placebo-response-and-remission-rates-in-randomised-trials-of-induction-and-maintenance-therapy-for-ulcerative-colitis
#5
REVIEW
Vipul Jairath, G Y Zou, Claire E Parker, John K MacDonald, Turki AlAmeel, Mohammad Al Beshir, Majid A Almadi, Talal Al-Taweel, Nathan Ss Atkinson, Sujata Biswas, Thomas Chapman, Parambir S Dulai, Mark A Glaire, Daniël R Hoekman, Andreas Koutsoumpas, Elizabeth Minas, Mahmoud H Mosli, Mark Samaan, Reena Khanna, Simon Travis, Geert D'Haens, William J Sandborn, Brian G Feagan
BACKGROUND: It is important to minimize placebo rates in randomised controlled trials (RCTs) to efficiently detect treatment differences between interventions. Historically, high placebo rates have been observed in clinical trials of ulcerative colitis (UC). A better understanding of factors influencing placebo rates may lead to more informed clinical trial design. OBJECTIVES: A systematic review and meta-analysis was conducted to evaluate placebo response and remission rates in RCTs evaluating UC treatments in adult patients...
September 8, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28808988/transoral-resection-of-human-papillomavirus-hpv-positive-squamous-cell-carcinoma-of-the-oropharynx-outcomes-with-and-without-adjuvant-therapy
#6
Ryan S Jackson, Parul Sinha, Joseph Zenga, Dorina Kallogjeri, Jasmina Suko, Eliot Martin, Eric J Moore, Bruce H Haughey
BACKGROUND: With the rise of oropharyngeal squamous cell carcinoma associated with human papillomavirus (HPV), appropriate treatment strategies continue to be tailored toward minimizing treatment while preserving oncologic outcomes. This study aimed to compare the outcomes for those undergoing transoral resection with or without adjuvant therapy for HPV-related oropharyngeal carcinoma. METHODS: A case-match cohort analysis was performed at two institutions on patients with HPV-related oropharyngeal squamous cell carcinoma...
November 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28768820/thrombectomy-versus-medical-management-for-large-vessel-occlusion-strokes-with-minimal-symptoms-an-analysis-from-stopstroke-and-gestor-cohorts
#7
Diogo C Haussen, Fabricio O Lima, Mehdi Bouslama, Jonathan A Grossberg, Gisele S Silva, Michael H Lev, Karen Furie, Walter Koroshetz, Michael R Frankel, Raul G Nogueira
INTRODUCTION: It remains unclear whether patients presenting with large vessel occlusion strokes and mild symptoms benefit from thrombectomy. OBJECTIVE: To compare outcomes of endovascular therapy versus medical management in patients with large vessel occlusion strokes and National Institute of Health Stroke Scale (NIHSS) score ≤5. METHODS: This was a retrospective analysis combining two large prospectively collected datasets including patients with (1) admission NIHSS score ≤5, (2) premorbid modified Rankin Scale (mRS) score 0-2, and (3) middle cerebral-M1/M2, intracranial carotid, anterior cerebral or basilar artery occlusions...
August 2, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/28753881/platinum-based-neoadjuvant-chemotherapy-improves-oncological-outcomes-in-patients-with-locally-advanced-upper-tract-urothelial-carcinoma
#8
Shogo Hosogoe, Shingo Hatakeyama, Ayumu Kusaka, Itsuto Hamano, Hiromichi Iwamura, Naoki Fujita, Hayato Yamamoto, Yuki Tobisawa, Tohru Yoneyama, Takahiro Yoneyama, Yasuhiro Hashimoto, Takuya Koie, Chikara Ohyama
BACKGROUND: Neoadjuvant chemotherapy (NAC) use for patients with locally advanced upper tract urothelial carcinoma (UTUC) is debatable. OBJECTIVE: To investigate the efficacy and safety of platinum-based NAC for locally advanced UTUC. DESIGN, SETTINGS, AND PARTICIPANTS: Of 233 consecutive patients who underwent radical nephroureterectomy, 55 patients received NAC (NAC group) and 138 patients did not (Ctrl group). OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: The two arms (Ctrl vs NAC) were matched using propensity scores to minimize selection bias...
April 7, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28708548/predicting-locations-of-high-risk-plaques-in-coronary-arteries-in-patients-receiving-statin-therapy
#9
Ling Zhang, Andreas Wahle, Zhi Chen, John J Lopez, Tomas Kovarnik, Milan Sonka
Features of high-risk coronary artery plaques prone to major adverse cardiac events (MACE) were identified by intravascular ultrasound (IVUS) virtual histology (VH). These plaque features are: Thin-cap fibroatheroma (TCFA), plaque burden PB≥70%, or minimal luminal area MLA≤4mm². Identification of arterial locations likely to later develop such high-risk plaques may help prevent MACE. We report a machine learning method for prediction of future high-risk coronary plaque locations and types in patients under statin therapy...
July 11, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28704255/choroidal-vascular-hyperpermeability-as-a-predictor-of-treatment-response-for-polypoidal-choroidal-vasculopathy
#10
Yasuo Yanagi, Daniel S W Ting, Wei Yan Ng, Shu Yen Lee, Ranjana Mathur, Choi Mun Chan, Ian Yeo, Tien Yin Wong, Gemmy Chui Ming Cheung
PURPOSE: To investigate the influence of choroidal vascular hyperpermeability (CVH) and choroidal thickness on treatment outcomes in eyes with polypoidal choroidal vasculopathy (PCV) undergoing anti-vascular endothelial growth factor monotherapy or combination therapy of photodynamic therapy and anti-vascular endothelial growth factor injections. METHODS: The authors performed a prospective, observational cohort study involving 72 eyes of 72 patients with polypoidal choroidal vasculopathy (mean age 68...
July 12, 2017: Retina
https://www.readbyqxmd.com/read/28595649/data-driven-prediction-of-adverse-drug-reactions-induced-by-drug-drug-interactions
#11
Ruifeng Liu, Mohamed Diwan M AbdulHameed, Kamal Kumar, Xueping Yu, Anders Wallqvist, Jaques Reifman
BACKGROUND: The expanded use of multiple drugs has increased the occurrence of adverse drug reactions (ADRs) induced by drug-drug interactions (DDIs). However, such reactions are typically not observed in clinical drug-development studies because most of them focus on single-drug therapies. ADR reporting systems collect information on adverse health effects caused by both single drugs and DDIs. A major challenge is to unambiguously identify the effects caused by DDIs and to attribute them to specific drug interactions...
June 8, 2017: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28552265/synergistic-target-combination-prediction-from-curated-signaling-networks-machine-learning-meets-systems-biology-and-pharmacology
#12
Huey Eng Chua, Sourav S Bhowmick, Lisa Tucker-Kellogg
Given a signaling network, the target combination prediction problem aims to predict efficacious and safe target combinations for combination therapy. State-of-the-art in silico methods use Monte Carlo simulated annealing (mcsa) to modify a candidate solution stochastically, and use the Metropolis criterion to accept or reject the proposed modifications. However, such stochastic modifications ignore the impact of the choice of targets and their activities on the combination's therapeutic effect and off-target effects, which directly affect the solution quality...
May 25, 2017: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/28458475/ormeloxifene-looking-beyond-contraception
#13
Tapasi Pati, Kabita Chanania, Satyabhama Marandi, Jagadish Hansa
AIMS: This study is aimed at finding out a logical solution for perimenopausal menorrhagia in normal or bulky uterus. SETTINGS AND DESIGN: The study is carried out at a tertiary care hospital at Odisha. In our setup, nearly 900 hysterectomies are done per year out of which 60% are for menorrhagia with bulky uterus. SUBJECTS AND METHODS: There were sixty cases of menorrhagia between the ages of 40 and 55 years who completed child bearing treated with ormeloxifene...
January 2017: Journal of Mid-life Health
https://www.readbyqxmd.com/read/28436889/design-and-implementation-of-a-tactile-stimulation-device-to-increase-auditory-discrimination
#14
Shahrzad Abbasi Baharanchi, Majid MohammadBeigi, Fatemeh Abnavi, Samira Tavakol
Reading is a complex process that requires various simultaneous brain processes. One of the most common types of reading disorders is developmental dyslexia, and one of the objectives of speech therapy sessions for children with developmental dyslexia is to increase their auditory discrimination. One of the most commonly used Auditory Discrimination Tests (ADTs) is Wepman's Auditory Discrimination Test (WADT). It includes minimal pair words categorized by characteristics of vowels and consonants. The goal of this research is to design and implement a tactile stimulation device based on Wepman's test to increase auditory discrimination in children with developmental dyslexia in therapy sessions, so that while playing each word for the children, vibrational cues are presented to their left palm and fingers...
April 24, 2017: IEEE Transactions on Haptics
https://www.readbyqxmd.com/read/28420326/transcriptional-changes-induced-by-bevacizumab-combination-therapy-in-responding-and-non-responding-recurrent-glioblastoma-patients
#15
Thomas Urup, Line Mærsk Staunstrup, Signe Regner Michaelsen, Kristoffer Vitting-Seerup, Marc Bennedbæk, Anders Toft, Lars Rønn Olsen, Lars Jønson, Shohreh Issazadeh-Navikas, Helle Broholm, Petra Hamerlik, Hans Skovgaard Poulsen, Ulrik Lassen
BACKGROUND: Bevacizumab combined with chemotherapy produces clinical durable response in 25-30% of recurrent glioblastoma patients. This group of patients has shown improved survival and quality of life. The aim of this study was to investigate changes in gene expression associated with response and resistance to bevacizumab combination therapy. METHODS: Recurrent glioblastoma patients who had biomarker-accessible tumor tissue surgically removed both before bevacizumab treatment and at time of progression were included...
April 18, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28408155/arthroscopic-capsular-plication-and-labral-seal-restoration-in-borderline-hip-dysplasia-2-year-clinical-outcomes-in-55-cases
#16
Sivashankar Chandrasekaran, Nader Darwish, Timothy J Martin, Carlos Suarez-Ahedo, Parth Lodhia, Benjamin G Domb
PURPOSE: To report clinical outcomes in patients with borderline dysplasia undergoing an arthroscopic technique of labral seal restoration with minimal acetabular rim resection and capsular plication. METHODS: Patients younger than 40 years with a lateral center-edge angle of 18° greater and 25° or less and 2-year follow-up after undergoing an arthroscopic technique of labral seal restoration with minimal rim resection (≤2 mm) and capsular plication (3-5 sutures placed in an oblique orientation to create an imbrication and inferior shift) were included...
July 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28333921/bioenergetics-based-modeling-of-plasmodium-falciparum-metabolism-reveals-its-essential-genes-nutritional-requirements-and-thermodynamic-bottlenecks
#17
Anush Chiappino-Pepe, Stepan Tymoshenko, Meriç Ataman, Dominique Soldati-Favre, Vassily Hatzimanikatis
Novel antimalarial therapies are urgently needed for the fight against drug-resistant parasites. The metabolism of malaria parasites in infected cells is an attractive source of drug targets but is rather complex. Computational methods can handle this complexity and allow integrative analyses of cell metabolism. In this study, we present a genome-scale metabolic model (iPfa) of the deadliest malaria parasite, Plasmodium falciparum, and its thermodynamics-based flux analysis (TFA). Using previous absolute concentration data of the intraerythrocytic parasite, we applied TFA to iPfa and predicted up to 63 essential genes and 26 essential pairs of genes...
March 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28329213/postoperative-pulmonary-complications-and-rehabilitation-requirements-following-lobectomy-a-propensity-score-matched-study-of-patients-undergoing-video-assisted-thoracoscopic-surgery-versus-thoracotomy%C3%A2
#18
Paula Agostini, Sebastian T Lugg, Kerry Adams, Nelia Vartsaba, Maninder S Kalkat, Pala B Rajesh, Richard S Steyn, Babu Naidu, Alison Rushton, Ehab Bishay
OBJECTIVES: : Video-assisted thoracoscopic surgical (VATS) lobectomy is increasingly used for curative intent lung cancer surgery compared to open thoracotomy due to its minimally invasive approach and associated benefits. However, the effects of the VATS approach on postoperative pulmonary complications (PPC), rehabilitation and physiotherapy requirements are unclear; our study aimed to use propensity score matching to investigate this. METHODS: Between January 2012 and January 2016 all consecutive patients undergoing lobectomy via thoracotomy or VATS were prospectively observed...
June 1, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28327443/correcting-delayed-circadian-phase-with-bright-light-therapy-predicts-improvement-in-adhd-symptoms-a-pilot-study
#19
Rachel E Fargason, Aaron D Fobian, Lauren M Hablitz, Jodi R Paul, Brittny A White, Karen L Cropsey, Karen L Gamble
Attention-deficit/hyperactivity disorder (ADHD) is a common condition with comorbid insomnia reported in >70% of children and adults. These patients demonstrate delays in sleep-wake rhythms, nocturnal rise in melatonin, and early morning rise in cortisol. Given that standard psychopharmacologic treatments for ADHD often do not completely control symptoms in participants with circadian rhythm delay, we sought to test whether bright light therapy (BLT) advances circadian rhythms and further reduces ADHD symptoms over standard treatments...
August 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28276077/quantifying-the-reproducibility-of-lung-ventilation-images-between-4-dimensional-cone-beam-ct-and-4-dimensional-ct
#20
Henry C Woodruff, Chun-Chien Shieh, Fiona Hegi-Johnson, Paul J Keall, John Kipritidis
PURPOSE: Computed tomography ventilation imaging derived from four-dimensional cone beam CT (CTVI(4DCBCT) ) can complement existing 4DCT-based methods (CTVI(4)(DCT) ) to track lung function changes over a course of lung cancer radiation therapy. However, the accuracy of CTVI(4)(DCBCT) needs to be assessed since anatomic 4DCBCT has demonstrably poor image quality and small field of view (FOV) compared to treatment planning 4DCT. We perform a direct comparison between short interval CTVI(4)(DCBCT) and CTVI(4)(DCT) pairs to understand the patient specific image quality factors affecting the intermodality CTVI reproducibility in the clinic...
March 9, 2017: Medical Physics
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