keyword
MENU ▼
Read by QxMD icon Read
search

Cycles approach

keyword
https://www.readbyqxmd.com/read/28231577/response-evaluation-in-head-and-neck-oncology-definition-and-prediction
#1
T K Hoffmann, P J Schuler, S Laban, R Grässlin, M Beer, A J Beer, U Friebe-Hoffmann, L Bullinger, P Möller, T Wiegel
Curative treatment of head and neck squamous cell carcinoma includes surgery and/or (chemo)radiation, whereas in the palliative setting, chemotherapy and/or immunotherapy represent(s) the standard approach. With regard to quality control, methods for determining treatment response are sorely needed. For surgical therapy, histopathology is the standard quality control. Established criteria for high-risk patients include resection margins of the primary tumor and extracapsular extension of lymph node metastases...
February 24, 2017: ORL; Journal for Oto-rhino-laryngology and its related Specialties
https://www.readbyqxmd.com/read/28230778/caffeic-acid-expands-anti-tumor-effect-of-metformin-in-human-metastatic-cervical-carcinoma-htb-34-cells-implications-of-ampk-activation-and-impairment-of-fatty-acids-de-novo-biosynthesis
#2
Malgorzata Tyszka-Czochara, Pawel Konieczny, Marcin Majka
The efficacy of cancer treatments is often limited and associated with substantial toxicity. Appropriate combination of drug targeting specific mechanisms may regulate metabolism of tumor cells to reduce cancer cell growth and to improve survival. Therefore, we investigated the effects of anti-diabetic drug Metformin (Met) and a natural compound caffeic acid (trans-3,4-dihydroxycinnamic acid, CA) alone and in combination to treat an aggressive metastatic human cervical HTB-34 (ATCC CRL-1550) cancer cell line...
February 21, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28230774/inhibition-of-ccar1-a-coactivator-of-%C3%AE-catenin-suppresses-the-proliferation-and-migration-of-gastric-cancer-cells
#3
Te-Sheng Chang, Kuo-Liang Wei, Chung-Kuang Lu, Yi-Hsing Chen, Ying-Tung Cheng, Shui-Yi Tung, Cheng-Shyong Wu, Ming-Ko Chiang
The aberrant activation of Wnt signaling has been implicated in a variety of human cancers, including gastric cancer. Given the current hypothesis that cancer arises from cancer stem cells (CSCs), targeting the critical signaling pathways that support CSC self-renewal appears to be a useful approach for cancer therapy. Cell cycle and apoptosis regulator 1 (CCAR1) is a transcriptional coactivator which has been shown to be a component of Wnt/β-catenin signaling, and which plays an important role in transcriptional regulation by β-catenin...
February 21, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28230366/investigation-of-ionization-pattern-of-the-adjacent-acidic-residues-in-the-dxdxe-motif-of-gh-18-chitinases-using-theoretical-pka-calculations
#4
Piyanat Meekrathok, Predrag Kukic, Jens Erik Nielsen, Wipa Suginta
GH-18 chitinases are chitinolytic enzymes, primarily responsible for the recycling of insoluble chitin biomaterials. These enzymes contain three invariant acidic active-site residues within a DXDXE motif, which play a synergistic role in the catalytic cycle of chitin degradation. We employed a pKa calculation approach to approximate the protonation states of residues D1, D2 and E in the DXDXE motif of 75 GH-18 chitinases. Theoretical pH-activity profiles of these enzymes were subsequently constructed and compared with the experimentally determined pH-activity profiles...
February 23, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28229558/microbial-diversity-of-a-full-scale-uasb-reactor-applied-to-poultry-slaughterhouse-wastewater-treatment-integration-of-16s-rrna-gene-amplicon-and-shotgun-metagenomic-sequencing
#5
Tiago Palladino Delforno, Gileno Vieira Lacerda Júnior, Melline F Noronha, Isabel K Sakamoto, Maria Bernadete A Varesche, Valéria M Oliveira
The 16S rRNA gene amplicon and whole-genome shotgun metagenomic (WGSM) sequencing approaches were used to investigate wide-spectrum profiles of microbial composition and metabolic diversity from a full-scale UASB reactor applied to poultry slaughterhouse wastewater treatment. The data were generated by using MiSeq 2 × 250 bp and HiSeq 2 × 150 bp Illumina sequencing platforms for 16S amplicon and WGSM sequencing, respectively. Each approach revealed a distinct microbial community profile, with Pseudomonas and Psychrobacter as predominant genus for the WGSM dataset and Clostridium and Methanosaeta for the 16S rRNA gene amplicon dataset...
February 23, 2017: MicrobiologyOpen
https://www.readbyqxmd.com/read/28229521/microbial-potential-for-carbon-and-nutrient-cycling-in-a-geogenic-supercritical-carbon-dioxide-reservoir
#6
Adam J E Freedman, BoonFei Tan, Janelle R Thompson
Microorganisms catalyze carbon cycling and biogeochemical reactions in the deep subsurface and thus may be expected to influence the fate of injected supercritical (sc) CO2 following geological carbon sequestration (GCS). We hypothesized that natural subsurface scCO2 reservoirs, which serve as analogs for the long-term fate of sequestered scCO2 , harbor a "deep carbonated biosphere" with carbon cycling potential. We sampled subsurface fluids from scCO2 -water separators at a natural scCO2 reservoir at McElmo Dome, Colorado for analysis of 16S rRNA gene diversity and metagenome content...
February 22, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28229109/interaction-between-circadian-rhythms-and-stress
#7
REVIEW
C E Koch, B Leinweber, B C Drengberg, C Blaum, H Oster
Life on earth has adapted to the day-night cycle by evolution of internal, so-called circadian clocks that adjust behavior and physiology to the recurring changes in environmental conditions. In mammals, a master pacemaker located in the suprachiasmatic nucleus (SCN) of the hypothalamus receives environmental light information and synchronizes peripheral tissues and central non-SCN clocks to geophysical time. Regulatory systems such as the hypothalamus-pituitary-adrenal (HPA) axis and the autonomic nervous system (ANS), both being important for the regulation of stress responses, receive strong circadian input...
February 2017: Neurobiology of Stress
https://www.readbyqxmd.com/read/28227935/heart-sound-segmentation-using-fractal-decomposition
#8
Rijil Thomas, Ling Lieng Hsi, Soh Cheong Boon, Erry Gunawan, Rijil Thomas, Ling Lieng Hsi, Soh Cheong Boon, Erry Gunawan
In order to assist cardiac diagnosis by phonocardiography, the automated identification of fundamental heart sounds for heart beat segmentation in a cardiac cycle plays a significant role in signal processing. Recent advancements in signal processing have also shown the potential of multifractality in biomedical applications. Hence, in this paper, the multifractal property of heart sounds is utilized to identify first and second heart sounds. The root mean square (rms) fluctuation used to obtain multifractal/singularity spectrum is used to decompose the heart sound into its own fractally-important components in time domain along with simultaneous Gaussianity test to filter out fundamental components...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227913/online-learning-of-gait-models-for-calculation-of-gait-parameters
#9
Jamie L S Waugh, Anton Trinh, Ryan R Mohammed, William E McIlroy, Dana Kulic, Jamie L S Waugh, Anton Trinh, Ryan R Mohammed, William E McIlroy, Dana Kulic, Jamie L S Waugh, Dana Kulic, Anton Trinh, William E McIlroy, Ryan R Mohammed
This paper proposes a novel approach for gait analysis from wearable sensing, based on an adaptive periodic model of any gait signal. The proposed method learns a model of the gait cycle during online measurement, using a continuous representation that can adapt to inter and intra-personal variability by creating an individualized model. Once the algorithm has converged to the input signal, key gait events can be identified relative to the estimated gait phase; these events can then be used to calculate gait parameters...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227456/a-morphological-approach-to-detect-respiratory-phases-of-seismocardiogram
#10
N Alamdari, K Tavakolian, V Zakeri, R Fazel-Rezai, A Akhbardeh, N Alamdari, K Tavakolian, V Zakeri, R Fazel-Rezai, A Akhbardeh, V Zakeri, N Alamdari, K Tavakolian, R Fazel-Rezai, A Akhbardeh
This paper presents a new approach to identify the respiratory phases of heart cycles from acceleration signals (i.e., seismocardiogram) recorded from the sternum, in back to front direction. The acceleration signals were recorded simultaneously with a single lead electrocardiogram (ECG), and the respiratory signal (using a chest band strain gauge) from 20 healthy subjects. Two accelerometer-derived respiration (ADR) signals were computed by computing the lower and upper envelope of the accelerometer signal...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227374/measuring-pulse-rate-variability-using-long-range-non-contact-imaging-photoplethysmography
#11
Ethan B Blackford, Alyssa M Piasecki, Justin R Estepp, Ethan B Blackford, Alyssa M Piasecki, Justin R Estepp, Ethan B Blackford, Alyssa M Piasecki, Justin R Estepp
Camera-based measurement of the blood volume pulse via non-contact, imaging photoplethysmography is a very popular approach for measuring pulse rate using a remote imaging sensor. Comparatively less attention has been paid to the usefulness of the method for measuring features of pulse rate variability, and even less focus has been put on the accuracy of any cardiac activity feature that can be achieved at long imager-to-subject distances. In this study, video was recorded from 19 participants, while at rest, at a distance of 25 meters from the imaging sensor...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227091/hybrid-bci-approach-to-control-an-artificial-tibio-femoral-joint
#12
Luis Mercado, Angel Rodriguez-Linan, Luis M Torres-Trevino, G Quiroz, Luis Mercado, Angel Rodriguez-Linan, Luis M Torres-Trevino, G Quiroz, Luis Mercado, Angel Rodriguez-Linan, Luis M Torres-Trevino, G Quiroz
Brain-Computer Interfaces (BCIs) for disabled people should allow them to use their remaining functionalities as control possibilities. BCIs connect the brain with external devices to perform the volition or intent of movement, regardless if that individual is unable to perform the task due to body impairments. In this work we fuse electromyographic (EMG) with electroencephalographic (EEG) activity in a framework called "Hybrid-BCI" (hBCI) approach to control the movement of a simulated tibio-femoral joint...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227069/automatic-annotation-of-peaks-in-seismocardiogram-for-systolic-time-intervals
#13
Ghufran Shafiq, Sivanagaraja Tatinati, Kalyana C Veluvolu, Ghufran Shafiq, Sivanagaraja Tatinati, Kalyana C Veluvolu, Kalyana C Veluvolu, Sivanagaraja Tatinati, Ghufran Shafiq
Siemocardiography is a non-invasive technique for cardiomechanical assessment by analyzing the local vibrations on chest surface which can be readily acquired from cost-effective accelerometers. The peaks in siesmocardiogram (SCG) signal correspond to underlying mechanical events in heart cycle and have numerious potential clinical and health-awareness applications. However, utilization of SCG signal requires annotation of these peaks that is challenging due to variations in inter-subject morphology and noise prone characteristics of SCG signal...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226918/gyrocardiography-a-new-non-invasive-approach-in-the-study-of-mechanical-motions-of-the-heart-concept-method-and-initial-observations
#14
Mojtaba Jafari Tadi, Eero Lehtonen, Mikko Pankaala, Antti Saraste, Tuija Vasankari, Mika Teras, Tero Koivisto, Mojtaba Jafari Tadi, Eero Lehtonen, Mikko Pankaala, Antti Saraste, Tuija Vasankari, Mika Teras, Tero Koivisto, Eero Lehtonen, Mojtaba Jafari Tadi, Mika Teras, Antti Saraste, Tuija Vasankari, Mikko Pankaala, Tero Koivisto
The pumping action of the heart is performed by contraction of the myocardium fibers. We present a non-invasive technique named gyrocardiography (GCG) that comprises a sensor of angular motion, gyroscope, configured to obtain three-dimensional angular velocity signals. A tri-axial micro electromechanical (MEMS) gyroscope sensor was attached to the surface of the chest to obtain gyrocardiogram. Color-coded Doppler tissue imaging (DTI) was recorded simultaneously and synchronized with the GCG in an off-line analysis...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226779/biologically-inspired-design-of-feedback-control-systems-implemented-using-dna-strand-displacement-reactions
#15
Mathias Foo, Rucha Sawlekar, Vishwesh V Kulkarni, Declan G Bates, Mathias Foo, Rucha Sawlekar, Vishwesh V Kulkarni, Declan G Bates, Vishwesh V Kulkarni, Rucha Sawlekar, Declan G Bates, Mathias Foo
The use of abstract chemical reaction networks (CRNs) as a modelling and design framework for the implementation of computing and control circuits using enzyme-free, entropy driven DNA strand displacement (DSD) reactions is starting to garner widespread attention in the area of synthetic biology. Previous work in this area has demonstrated the theoretical plausibility of using this approach to design biomolecular feedback control systems based on classical proportional-integral (PI) controllers, which may be constructed from CRNs implementing gain, summation and integrator operators...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225588/self-assembled-and-one-step-synthesis-of-interconnected-3d-network-of-fe3o4-reduced-graphene-oxide-nanosheets-hybrid-for-high-performance-supercapacitor-electrode
#16
Rajesh Kumar, Rajesh Kumar Singh, Alfredo R Vaz, Raluca Savu, Stanislav A Moshkalev
In the present work, we have synthesized three dimensional (3D) reduced graphene oxide nanosheets (rGO NSs) containing iron oxide nanoparticles (Fe3O4 NPs) hybrids (3D Fe3O4/rGO) by one-pot microwave approach. Structural and morphological studies reveal that the as-synthesized Fe3O4/rGO hybrids were composed of faceted Fe3O4 NPs induced into the interconnected network of rGO NSs. The morphologies and structures of the 3D hybrids have been characterized using scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), Raman spectroscopy and X-ray photoelectron spectrometer (XPS)...
February 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28224921/lemna-minor-plants-chronically-exposed-to-ionising-radiation-rna-seq-analysis-indicates-a-dose-rate-dependent-shift-from-acclimation-to-survival-strategies
#17
Arne Van Hoeck, Nele Horemans, Robin Nauts, May Van Hees, Hildegarde Vandenhove, Ronny Blust
Ecotoxicological research provides knowledge on ionising radiation-induced responses in different plant species. However, the sparse data currently available are mainly extracted from acute exposure treatments. To provide a better understanding of environmental exposure scenarios, the response to stress in plants must be followed in more natural relevant chronic conditions. We previously showed morphological and biochemical responses in Lemna minor plants continuously exposed for 7days in a dose-rate dependent manner...
April 2017: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/28224622/slc2a3-single-nucleotide-polymorphism-and-duplication-influence-cognitive-processing-and-population-specific-risk-for-attention-deficit-hyperactivity-disorder
#18
Sören Merker, Andreas Reif, Georg C Ziegler, Heike Weber, Ute Mayer, Ann-Christine Ehlis, Annette Conzelmann, Stefan Johansson, Clemens Müller-Reible, Indrajit Nanda, Thomas Haaf, Reinhard Ullmann, Marcel Romanos, Andreas J Fallgatter, Paul Pauli, Tatyana Strekalova, Charline Jansch, Alejandro Arias Vasquez, Jan Haavik, Marta Ribasés, Josep Antoni Ramos-Quiroga, Jan K Buitelaar, Barbara Franke, Klaus-Peter Lesch
BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is a common, highly heritable neurodevelopmental disorder with profound cognitive, behavioral, and psychosocial impairments with persistence across the life cycle. Our initial genome-wide screening approach for copy number variants (CNVs) in ADHD implicated a duplication of SLC2A3, encoding glucose transporter-3 (GLUT3). GLUT3 plays a critical role in cerebral glucose metabolism, providing energy for the activity of neurons, which, in turn, moderates the excitatory-inhibitory balance impacting both brain development and activity-dependent neural plasticity...
February 22, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28224245/evaluation-of-ms-2-workflows-in-lc-q-orbitrap-for-pesticide-multi-residue-methods-in-fruits-and-vegetables
#19
Łukasz Rajski, María Del Mar Gómez Ramos, Amadeo R Fernández-Alba
LC-Q-Orbitrap efficiency was evaluated for pesticide multi-residue analysis by using three workflows involving simultaneous MS and MS(2) analysis. They were as follows: data-dependent MS(2) (dd-MS(2)), all-ion fragmentation (AIF) and variable data-independent analysis (vDIA). These MS(2) workflows were tested for the main method validation parameters such as detection and identification capabilities, repeatability, linear range and quantitation. QuEChER acetonitrile extracts (blanks and spiked with 166 pesticides) of 11 different fruits and vegetables were used for this evaluation...
February 21, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28223686/metabolic-profiling-of-presymptomatic-huntington-s-disease-sheep-reveals-novel-biomarkers
#20
Debra J Skene, Benita Middleton, Cara K Fraser, Jeroen L A Pennings, Timothy R Kuchel, Skye R Rudiger, C Simon Bawden, A Jennifer Morton
The pronounced cachexia (unexplained wasting) seen in Huntington's disease (HD) patients suggests that metabolic dysregulation plays a role in HD pathogenesis, although evidence of metabolic abnormalities in HD patients is inconsistent. We performed metabolic profiling of plasma from presymptomatic HD transgenic and control sheep. Metabolites were quantified in sequential plasma samples taken over a 25 h period using a targeted LC/MS metabolomics approach. Significant changes with respect to genotype were observed in 89/130 identified metabolites, including sphingolipids, biogenic amines, amino acids and urea...
February 22, 2017: Scientific Reports
keyword
keyword
74685
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"