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https://www.readbyqxmd.com/read/29679827/environmental-impact-assessment-of-alfalfa-medicago-sativa-l-hay-production
#1
Jacopo Bacenetti, Daniela Lovarelli, Doriana Tedesco, Roberto Pretolani, Valentina Ferrante
On-farm production of hay and high-protein-content feed has several advantages such as diversification of on-farm cultivated crops, reduction of off-farm feed concentrates transported over long distances and a reduction in runoff during the winter season if grown crops are perennial. Among those crops cultivated for high-protein-content feed, alfalfa (Medicago sativa L.) is one of the most important in the Italian context. Nevertheless, up to now, only a few studies have assessed the environmental performance of alfalfa hay production...
April 18, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29679745/integrated-genomic-and-metabolomic-profiling-of-isc1-an-emerging-leishmania-donovani-population-in-the-indian-subcontinent
#2
Bart Cuypers, Maya Berg, Hideo Imamura, Franck Dumetz, Géraldine De Muylder, Malgorzata A Domagalska, Suman Rijal, Narayan Raj Bhattarai, Ilse Maes, Mandy Sanders, James A Cotton, Pieter Meysman, Kris Laukens, Jean-Claude Dujardin
Leishmania donovani is the responsible agent for visceral leishmaniasis (VL) in the Indian subcontinent (ISC). The disease is lethal without treatment and causes 0.2 to 0.4 million cases each year. Recently, reports of VL in Nepalese hilly districts have increased as well as VL cases caused by L. donovani from the ISC1 genetic group, a new and emerging genotype. In this study, we perform for the first time an integrated, untargeted genomics and metabolomics approach to characterize ISC1, in comparison with the Core Group (CG), main population that drove the last outbreak of VL in the ISC...
April 18, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29679304/analytic-approaches-for-the-treatment-of-hyperhomocysteinemia-and-its-impact-on-vascular-disease
#3
REVIEW
Soo-Sang Kang, Robert S Rosenson
Homocysteine is an intermediary metabolite in the methionine cycle. Accumulation of homocysteine is caused either by mutation of relevant genes or by nutritional depletion of related vitamin(s). This review covers the historical background of hyperhomocysteinemia in which indispensable subjects in relation to underlying pathophysiological processes are discussed with the view of metabolism and genetics of folate and methionine cycles. This review emphasizes the unique role of homocysteine that is clearly distinct from other risk factors, particularly cholesterol in the development of vascular disease...
April 20, 2018: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/29678304/improving-postoperative-neonatal-nutritional-practices-in-an-intensive-care-unit-using-the-pdsa-cycle
#4
Jennifer Newcombe, Eileen Fry-Bowers
Quality Improvement models offer a framework for health care professionals to follow in implementing process improvement changes. Use of these models promotes a systematic approach to problem solving, keeps providers from eliminating important steps, facilitates team work, and provides a clear plan for ongoing communication. This paper describes use of the Plan-Do-Study-Act model to implement a unit-based quality improvement project that focused on improving postoperative nutritional practices for neonates with critical congenital heart disease following complex cardiac surgery...
April 17, 2018: Journal of Pediatric Health Care
https://www.readbyqxmd.com/read/29677520/stable-black-phosphorus-bi-2-o-3-heterostructures-for-synergistic-cancer-radiotherapy
#5
Hao Huang, Lizhen He, Wenhua Zhou, Guangbo Qu, Jiahong Wang, Na Yang, Jie Gao, Tianfeng Chen, Paul K Chu, Xue-Feng Yu
X-ray induced photodynamic therapy (X-ray-PDT) is a promising approach for synergistic cancer radiotherapy and development of suitable radiosensitizers is highly desired. In this paper, we propose black phosphorus/Bi2 O3 (BP/Bi2 O3 ) heterostructures as efficient and biocompatible radiosensitizers for synergistic cancer radiotherapy. The heterostructures are synthesized by growth of ultrasmall Bi2 O3 nanoparticles onto BP nanosheets. The Bi2 O3 decoration inhibits the rapid degradation of BP nanosheets by occupation of the defect sites, and the synergistic effects of BP and Bi2 O3 enable 1 O2 overproduction under X-ray irradiation...
April 13, 2018: Biomaterials
https://www.readbyqxmd.com/read/29677511/an-integrated-genome-wide-crispra-approach-to-functionalize-lncrnas-in-drug-resistance
#6
Assaf C Bester, Jonathan D Lee, Alejandro Chavez, Yu-Ru Lee, Daphna Nachmani, Suhani Vora, Joshua Victor, Martin Sauvageau, Emanuele Monteleone, John L Rinn, Paolo Provero, George M Church, John G Clohessy, Pier Paolo Pandolfi
Resistance to chemotherapy plays a significant role in cancer mortality. To identify genetic units affecting sensitivity to cytarabine, the mainstay of treatment for acute myeloid leukemia (AML), we developed a comprehensive and integrated genome-wide platform based on a dual protein-coding and non-coding integrated CRISPRa screening (DICaS). Putative resistance genes were initially identified using pharmacogenetic data from 760 human pan-cancer cell lines. Subsequently, genome scale functional characterization of both coding and long non-coding RNA (lncRNA) genes by CRISPR activation was performed...
April 19, 2018: Cell
https://www.readbyqxmd.com/read/29677037/small-left-ventricular-size-is-an-independent-risk-factor-for-ventricular-assist-device-thrombosis
#7
Venkat Keshav Chivukula, Jennifer A Beckman, Anthony R Prisco, Shin Lin, Todd F Dardas, Richard K Cheng, Stephen D Farris, Jason W Smith, Nahush A Mokadam, Claudius Mahr, Alberto Aliseda
The prevalence of ventricular assist device (VAD) therapy has continued to increase due to a stagnant donor supply and growing advanced heart failure (HF) population. We hypothesize that left ventricular (LV) size strongly influences biocompatibility and risk of thrombosis. Unsteady computational fluid dynamics (CFD) was used in conjunction with patient-derived computational modeling and virtual surgery with a standard, apically implanted inflow cannula. A dual-focus approach of evaluating thrombogenicity was employed: platelet-based metrics to characterize the platelet environment and flow-based metrics to investigate hemodynamics...
April 18, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29676903/multi-scale-engineered-si-sio-x-nanocomposite-electrodes-for-lithium-ion-batteries-using-layer-by-layer-spray-deposition
#8
Chun Huang, Ayoung Kim, Dong Jae Chung, Eunjun Park, Neil P Young, Kerstin Jurkschat, Hansu Kim, Patrick S Grant
Si-based high capacity materials have gained much attention as an alternative to graphite in Li ion battery anodes. Although Si additions to graphite anodes are now commercialised, the fraction of Si that can be usefully exploited is restricted due to its poor cyclability arising from the large volume changes during charge/discharge. Si/SiOx nanocomposites have also shown promising behaviour, such as better capacity retention than Si alone because the amorphous SiOx helps to accommodate the volume changes of the Si...
April 20, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29676528/e3-ubiquitin-ligase-rnf123-targets-lamin-b1-and-lamin-binding-proteins
#9
Richa Khanna, Vidhya Krishnamoorthy, Veena K Parnaik
Lamins are key nuclear proteins which are important for maintaining nuclear structure and function. Mutations in lamins cause a spectrum of genetic diseases termed as laminopathies. RING finger containing E3 ubiquitin ligase, RNF123 is transcriptionally upregulated in cells expressing rod-domain lamin A mutations. However, the functional relevance of RNF123 in laminopathic cells is not clear. Using a mass spectrometry based approach, we identified lamins and lamin-binding proteins retinoblastoma protein (pRb), lamina-associated polypeptide 2α (LAP2α) and emerin as RNF123-interacting proteins...
April 20, 2018: FEBS Journal
https://www.readbyqxmd.com/read/29676152/anti-cancer-effects-of-emodin-on-hepg2-cells-as-revealed-by-1h-nmr-based-metabolic-profiling
#10
Yue-Xiao Xing, Ming-Hui Li, Liang Tao, Ling-Yu Ruan, Wei Hong, Cheng Chen, Wen-Long Zhao, Han Xu, Jian-Feng Chen, Jun-Song Wang
Hepatic carcinoma is one of the most common cancers in the world with a high incidence. Emodin is an anthraquinone derived from Polygonum multiflorum Thunb, possessing anti-cancer activity. The purpose of this study is to investigate the anti-cancer effect of different dosages of emodin on HepG2 cells using 1H-NMR based metabolic approach complemented with qRT-PCR and flow cytometry to identify potential markers and discover the targets to explore the underlying mechanism. Emodin can dose-dependently inhibit the growth of HepG2 cells, perturb cell cycle progression, down-regulate the expression of genes and proteins related to glycolysis and trigger intracellular ROS generation...
April 20, 2018: Journal of Proteome Research
https://www.readbyqxmd.com/read/29675716/disturbances-of-sleep-and-alertness-in-parkinson-s-disease
#11
REVIEW
Aleksandar Videnovic
PURPOSE OF REVIEW: Parkinson's disease (PD) is the second most common neurodegenerative disorder. Sleep dysfunction is one of the most common non-motor manifestations of PD that has gained significant interest over the past two decades due to its impact on the daily lives of PD patients, poorly understood mechanisms, and limited treatment options. In this review, we discuss the most common sleep disorders in PD and present recent investigations that have broadened our understanding of the epidemiology, clinical manifestations, diagnosis, and treatment of disturbed sleep and alertness in PD...
April 19, 2018: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/29675013/development-of-chemically-defined-media-reveals-citrate-as-preferred-carbon-source-for-liberibacter-growth
#12
Maritsa Cruz-Munoz, Joseph R Petrone, Alexa R Cohn, Alam Munoz-Beristain, Nabil Killiny, Jennifer C Drew, Eric W Triplett
Liberibacter crescens is the closest cultured relative of four important uncultured crop pathogens. Candidatus L. asiaticus, L. americanus, and L. africanus are causal agents of citrus greening disease, otherwise known as huanglongling (HLB). Candidatus L. solanacearum is responsible for potato Zebra chip disease. Cultures of L. crescens grow slowly on BM-7 complex medium, while attempts to culture the Ca. Liberibacter pathogens in BM-7 have failed. Developing a defined medium for the growth of L. crescens will be useful in the study of Liberibacter metabolism and will improve the prospects for culturing the Ca ...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29674991/when-teams-fail-to-self-regulate-predictors-and-outcomes-of-team-procrastination-among-debating-teams
#13
Edwin A J Van Hooft, Heleen Van Mierlo
Models of team development have indicated that teams typically engage in task delay during the first stages of the team's life cycle. An important question is to what extent this equally applies to all teams, or whether there is variation across teams in the amount of task delay. The present study introduces the concept of team procrastination as a lens through which we can examine whether teams collectively engage in unplanned, voluntary, and irrational delay of team tasks. Based on theory and research on self-regulation, team processes, and team motivation we developed a conceptual multilevel model of predictors and outcomes of team procrastination...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29674690/ultrasound-activated-piezoelectric-nanoparticles-inhibit-proliferation-of-breast-cancer-cells
#14
Attilio Marino, Matteo Battaglini, Daniele De Pasquale, Andrea Degl'Innocenti, Gianni Ciofani
A nanotechnology-based approach for the inhibition of breast cancer cell proliferation is proposed. The innovative solution consists in a platform based on biocompatible piezoelectric nanoparticles able to target and remotely stimulate HER2-positive breast cancer cells. The anti-proliferative effects of the ultrasound-driven piezoelectric nanoparticle-assisted stimulation significantly reduced the proliferation by inducing the cell cycle arrest. Similarly to a low-intensity alternating electric field, chronic piezoelectric stimulation resulted able to inhibit cancer cell proliferation by upregulating the expression of the gene encoding Kir3...
April 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29674514/pharmacokinetic-studies-in-children-recommendations-for-practice-and-research
#15
REVIEW
Charlotte I S Barker, Joseph F Standing, Lauren E Kelly, Lauren Hanly Faught, Allison C Needham, Michael J Rieder, Saskia N de Wildt, Martin Offringa
Optimising the dosing of medicines for neonates and children remains a challenge. The importance of pharmacokinetic (PK) and pharmacodynamic (PD) research is recognised both in medicines regulation and paediatric clinical pharmacology, yet there remain barriers to undertaking high-quality PK and PD studies. While these studies are essential in understanding the dose-concentration-effect relationship and should underpin dosing recommendations, this review examines how challenges affecting the design and conduct of paediatric pharmacological studies can be overcome using targeted pharmacometric strategies...
April 19, 2018: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29674451/fully-reduced-hmgb1-accelerates-the-regeneration-of-multiple-tissues-by-transitioning-stem-cells-to-g-alert
#16
Geoffrey Lee, Ana Isabel Espirito Santo, Stefan Zwingenberger, Lawrence Cai, Thomas Vogl, Marc Feldmann, Nicole J Horwood, James K Chan, Jagdeep Nanchahal
A major discovery of recent decades has been the existence of stem cells and their potential to repair many, if not most, tissues. With the aging population, many attempts have been made to use exogenous stem cells to promote tissue repair, so far with limited success. An alternative approach, which may be more effective and far less costly, is to promote tissue regeneration by targeting endogenous stem cells. However, ways of enhancing endogenous stem cell function remain poorly defined. Injury leads to the release of danger signals which are known to modulate the immune response, but their role in stem cell-mediated repair in vivo remains to be clarified...
April 19, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29674368/effectiveness-of-the-facility-based-maternal-near-miss-case-reviews-in-improving-maternal-and-newborn-quality-of-care-in-low-income-and-middle-income-countries-a-systematic-review
#17
Marzia Lazzerini, Sonia Richardson, Valentina Ciardelli, Anna Erenbourg
OBJECTIVES: The maternal near-miss case review (NMCR) has been promoted by WHO as an approach to improve quality of care (QoC) at facility level. This systematic review synthesises evidence on the effectiveness of the NMCR on QoC and maternal and perinatal health outcomes in low-income and middle-income countries (LMICs). METHODS: Studies were searched for in six electronic databases (MEDLINE, Index Medicus, Web of Science, the Cochrane library, Embase, LILACS), with no language restrictions...
April 19, 2018: BMJ Open
https://www.readbyqxmd.com/read/29674283/controlled-deposition-of-fullerene-derivatives-within-a-graphene-template-by-means-of-a-modified-langmuir-schaefer-method
#18
Antonios Kouloumpis, Nikolaos Vourdas, Panagiota Zygouri, Nikolaos Chalmpes, Georgia Potsi, Vasilios Kostas, Konstantinos Spyrou, Vassilis N Stathopoulos, Dimitrios Gournis, Petra Rudolf
The scientific and technological potential of graphene's includes the development of light, open 3D hybrid structures with high surface area, tunable pore size and aromatic functionalities. Towards this aim, we describe a scalable and low-cost bottom-up approach that combines self-assembly and Langmuir-Schaefer deposition for the production of fullerene-intercalated graphene oxide hybrids. This method uses graphene oxide (GO) nanosheets as template for the attachment of two types of fullerene derivatives (bromo-fullerenes, C60 Br24 and fullerols, C60 (OH)24 ) in a bi-dimensional arrangement, allowing a layer-by-layer growth with control at nanoscale...
April 12, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29674095/effects-of-tri%C3%AF-uralin-on-the-soil-microbial-community-and-functional-groups-involved-in-nitrogen-cycling
#19
Pengqiang Du, Xiaohu Wu, Jun Xu, Fengshou Dong, Xingang Liu, Yongquan Zheng
Large amounts of trifluralin are applied each year for weed control; however, its effects on soil microbial communities and functions are unknown. Two agricultural soils, one silty loam and one silty clay were spiked with TFL (0, 0.84, 8.4, and 84 mg kg-1 ) and studied the effects using a laboratory microcosm approach. The half-lives were 44.19-61.83 d in all cases. Bacterial abundance increased 1.12-5.56 times by TFL, but the diversity decreased. From the next-generation sequencing results, TFL altered the bacterial community structure, which initially diverged from the control community structure, then recovered, and then diverged again...
April 10, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29674042/qbd-approach-by-computer-aided-design-and-response-surface-methodology-for-molecularly-imprinted-polymer-based-on-magnetic-halloysite-nanotubes-for-extraction-of-norfloxacin-from-real-samples
#20
Meriem Fizir, Liu Wei, Niu Muchuan, Asma Itatahine, Yamina Ait Mehdi, Hua He, Pierre Dramou
This article describes the development, optimization, and evaluation of a novel composite imprinted polymer, on the basis of magnetic halloysite nanotubes (MHNTs-MIPs) using "Quality by Design (QbD)" approach combining computer simulation and response surface methodology. Norfloxacin, methacrylic acid, and ethylene glycol dimethacrylate were used as template, functional monomer and cross-linker, respectively. As a comparison, two MHNTs-MIPs have been prepared with the most suitable functional monomer methacrylic acid (MAA) along with acrylamide (AM)...
July 1, 2018: Talanta
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