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https://www.readbyqxmd.com/read/29917310/on-the-role-of-the-tricarboxylic-acid-cycle-in-plant-productivity
#1
REVIEW
Youjun Zhang, Alisdair R Fernie
The tricarboxylic acid (TCA) cycle is one of the canonical energy pathways of living systems, as well as being an example of a pathway in which dynamic enzyme assemblies, or metabolons, are well characterized. The role of the enzymes have been the subject of saturated transgenesis approaches, whereby the expression of the constituent enzymes were reduced or knocked out in order to ascertain their in vivo function. Some of the resultant plants exhibited improved photosynthesis and plant growth, under controlled greenhouse conditions...
June 19, 2018: Journal of Integrative Plant Biology
https://www.readbyqxmd.com/read/29917231/itch-and-psyche-psychiatric-aspects-of-pruritus
#2
REVIEW
Mohammad Jafferany, Maryam E Davari
Itch, also referred to as pruritus, is an unpleasant cutaneous sensation provoking the desire to scratch. It is often an uncomfortable, subjective sensation responsible for decreased quality of life in a variety of psychodermatological conditions. Comorbid psychiatric conditions, including depression and anxiety, are frequently associated with itch and scratch cycle. The reciprocal and intricate relationship between the psyche and itch has been widely studied. The neurobiology of itch involves the complexity of specific mediators, itch-related neuronal pathways, and central processing of itch...
June 19, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29916218/pharmacogenetic-algorithm-for-individualized-controlled-ovarian-stimulation-icos-in-assisted-reproductive-technology-cycles
#3
Matheus Roque, Bianca Bianco, Denise M Christofolini, Emerson B Cordts, Fabia L Vilarino, Waldemar Carvalho, Marcello Valle, Marcos Sampaio, Selmo Geber, Sandro C Esteves, Caio P Barbosa
Controlled ovarian stimulation (COS) is crucial for optimizing in vitro fertilization (IVF) / intracytoplasmic sperm injection (ICSI) success. Multiple factors influence the ovarian response to COS, making predictions about oocyte yields not so straightforward. As a result, the ovarian response may be poor or suboptimal, or even excessive, all of which have negative consequences for the affected patient. There is a group of patients that present with a suboptimal response to COS despite normal biomarkers of ovarian reserve, such as AFC and AMH...
June 14, 2018: Panminerva Medica
https://www.readbyqxmd.com/read/29916047/an-agent-based-model-of-the-fission-yeast-cell-cycle
#4
Carlos Castro, Dora-Luz Flores, David Cervantes-Vásquez, Eunice Vargas-Viveros, Everardo Gutiérrez-López, Franklin Muñoz-Muñoz
The objective of this paper is to develop a computational model of the fission yeast (Schizosaccharomyces pombe) cell cycle using agent-based modeling (ABM), to study the sequence of states of the proteins and time of the cell cycle phases, under the action of proteins that regulate its cell cycle. The model relies only on the conceptual model of the yeast cell cycle regulatory network, where each protein has been represented as an agent with a property called activity that represents its biological function and a stochastic Brownian movement...
June 18, 2018: Current Genetics
https://www.readbyqxmd.com/read/29915929/identification-of-mir-146a-is-associated-with-the-aggressiveness-and-suppresses-proliferation-via-targeting-cdkn2a-in-breast-cancer
#5
Yanping Zhang, Shi Ding, Jie Yang, Xingfeng Chen, Weilin Huang
There is emerging evidence that some microRNAs can promote or suppress several human cancer development and progression. However, the profile and molecular mechanism of microRNAs for human breast cancer is poorly unknown. We used bioinformatics approaches to find new candidate diagnostic and therapeutic miRNAs in human breast cancer via analysis of TCGA RNA sequencing data and publicly GEO microarray data, in order to provide theoretical basis for the future investigations of breast cancer. Decreased expression miR-146a was identified as a key regulator of human breast cancer development and progression...
June 18, 2018: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/29915279/ms-analysis-of-a-dilution-series-of-bacteria-phytoplankton-to-improve-detection-of-low-abundance-bacterial-peptides
#6
Emma Timmins-Schiffman, Molly P Mikan, Ying Sonia Ting, H Rodger Harvey, Brook L Nunn
Assigning links between microbial activity and biogeochemical cycles in the ocean is a primary objective for ecologists and oceanographers. Bacteria represent a small ecosystem component by mass, but act as the nexus for both nutrient transformation and organic matter recycling. There are limited methods to explore the full suite of active bacterial proteins largely responsible for degradation. Mass spectrometry (MS)-based proteomics now has the potential to document bacterial physiology within these complex systems...
June 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29915236/single-molecule-probing-of-the-conformational-homogeneity-of-the-abc-transporter-btucd
#7
Min Yang, Nurit Livnat Levanon, Burçin Acar, Burcu Aykac Fas, Gal Masrati, Jessica Rose, Nir Ben-Tal, Turkan Haliloglu, Yongfang Zhao, Oded Lewinson
ATP-binding cassette (ABC) transporters use the energy of ATP hydrolysis to move molecules through cellular membranes. They are directly linked to human diseases, cancer multidrug resistance, and bacterial virulence. Very little is known of the conformational dynamics of ABC transporters, especially at the single-molecule level. Here, we combine single-molecule spectroscopy and a novel molecular simulation approach to investigate the conformational dynamics of the ABC transporter BtuCD. We observe a single dominant population of molecules in each step of the transport cycle and tight coupling between conformational transitions and ligand binding...
July 2018: Nature Chemical Biology
https://www.readbyqxmd.com/read/29915105/persistent-bacterial-and-fungal-community-shifts-exhibited-in-selenium-contaminated-reclaimed-mine-soils
#8
Carla E Rosenfeld, Bruce R James, Cara Santelli
Mining and other industrial activities worldwide have resulted in Se-enriched surface soils, which pose risks to human and environmental health. Although not well studied, microbial activity can alter Se bioavailability and distribution, even in oxic environments. We used high throughput sequencing to profile bacterial and fungal communities inhabiting mine soils in southeastern Idaho, comparing mined and unmined locations within two reclaimed phosphate mine areas containing variable Se concentrations. The goal was to determine whether microbial communities differed in (i) different mines, (ii) mined areas compared to unmined areas, and (iii) varying soil Se concentrations...
June 18, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29915083/early-loss-of-mitochondrial-complex-i-and-rewiring-of-glutathione-metabolism-in-renal-oncocytoma
#9
Raj K Gopal, Sarah E Calvo, Angela R Shih, Frances L Chaves, Declan McGuone, Eran Mick, Kerry A Pierce, Yang Li, Andrea Garofalo, Eliezer M Van Allen, Clary B Clish, Esther Oliva, Vamsi K Mootha
Renal oncocytomas are benign tumors characterized by a marked accumulation of mitochondria. We report a combined exome, transcriptome, and metabolome analysis of these tumors. Joint analysis of the nuclear and mitochondrial (mtDNA) genomes reveals loss-of-function mtDNA mutations occurring at high variant allele fractions, consistent with positive selection, in genes encoding complex I as the most frequent genetic events. A subset of these tumors also exhibits chromosome 1 loss and/or cyclin D1 overexpression, suggesting they follow complex I loss...
June 18, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29914863/analysis-of-the-features-important-for-the-effectiveness-of-physical-activity-related-apps-for-recreational-sports-expert-panel-approach
#10
Joan Dallinga, Mark Janssen, Jet van der Werf, Ruben Walravens, Steven Vos, Marije Deutekom
BACKGROUND: A large number of people participate in individual or unorganized sports on a recreational level. Furthermore, many participants drop out because of injury or lowered motivation. Potentially, physical activity-related apps could motivate people during sport participation and help them to follow and maintain a healthy active lifestyle. It remains unclear what the quality of running, cycling, and walking apps is and how it can be assessed. Quality of these apps was defined as having a positive influence on participation in recreational sports...
June 18, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29914790/transition-to-parenthood-consequences-on-health-and-well-being-a-qualitative-study
#11
Cristina Araújo Martins
OBJECTIVE: Parenthood is one of the most dramatic developmental transitions in the family life cycle. It requires profound changes in lifestyle, roles and relationships, can increase stress levels and affects both men and women's quality of life. This study aimed to explore the effects on the health and well-being of parents during the first six months of transition to the parental role. METHOD: A qualitative study using the grounded theory approach. Data collection was from semi-structured interviews (total of 60 interviews)...
June 15, 2018: Enfermería Clínica
https://www.readbyqxmd.com/read/29914207/a-fog-computing-based-cyber-physical-system-for-the-automation-of-pipe-related-tasks-in-the-industry-4-0-shipyard
#12
Tiago M Fernández-Caramés, Paula Fraga-Lamas, Manuel Suárez-Albela, Manuel A Díaz-Bouza
Pipes are one of the key elements in the construction of ships, which usually contain between 15,000 and 40,000 of them. This huge number, as well as the variety of processes that may be performed on a pipe, require rigorous identification, quality assessment and traceability. Traditionally, such tasks have been carried out by using manual procedures and following documentation on paper, which slows down the production processes and reduces the output of a pipe workshop. This article presents a system that allows for identifying and tracking the pipes of a ship through their construction cycle...
June 17, 2018: Sensors
https://www.readbyqxmd.com/read/29914143/preparation-of-enzyme-activated-thapsigargin-prodrugs-by-solid-phase-synthesis
#13
Tomas Zimmermann, Søren Brøgger Christensen, Henrik Franzyk
Since cells in solid tumors divide less rapidly than cells in the bone marrow or cells of the immune system, mitotic inhibitors often cause severe side effects when used for treatment of diseases like prostate cancer and breast cancer. One approach to overcome this problem involves attempts at developing drugs based on general cytotoxins, like calicheamicin and thapsigargin, which kill cells at all phases of the cell cycle. However, such toxins can only be used when efficient targeting to the malignant tissue is possible...
June 15, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29913479/prioritizing-and-modelling-of-putative-drug-target-proteins-of-candida-albicans-by-systems-biology-approach
#14
Tariq Ismail, Nighat Fatima, Syed Aun Muhammad, Syed Saoud Zaidi, Nisar Rehman, Izhar Hussain, Najam Us Sahr Tariq, Imran Amirzada, Abdul Mannan
Candida albicans (Candida albicans) is one of the major sources of nosocomial infections in humans which may prove fatal in 30% of cases. The hospital acquired infection is very difficult to treat affectively due to the presence of drug resistant pathogenic strains, therefore there is a need to find alternative drug targets to cure this infection. In silico and computational level frame work was used to prioritize and establish antifungal drug targets of Candida albicans. The identification of putative drug targets was based on acquiring 5090 completely annotated genes of Candida albicans from available databases which were categorized into essential and non-essential genes...
2018: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/29913370/consistent-criticality-and-radiation-studies-of-swiss-spent-nuclear-fuel-the-cs-2-m-approach
#15
D Rochman, A Vasiliev, H Ferroukhi, M Pecchia
In this paper, a new method is proposed to systematically calculate at the same time canister loading curves and radiation sources, based on the inventory information from an in-core fuel management system. As a demonstration, the isotopic contents of the assemblies come from a Swiss PWR, considering more than 6000 cases from 34 reactor cycles. The CS2 M approach consists in combining four codes: CASMO and SIMULATE to extract the assembly characteristics (based on validated models), the SNF code for source emission and MCNP for criticality calculations for specific canister loadings...
June 15, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29913283/tuning-functions-for-automatic-detection-of-brief-changes-of-facial-expression-in-the-human-brain
#16
Arnaud Leleu, Milena Dzhelyova, Bruno Rossion, Renaud Brochard, Karine Durand, Benoist Schaal, Jean-Yves Baudouin
Efficient decoding of even brief and slight intensity facial expression changes is important for social interactions. However, robust evidence for the human brain ability to automatically detect brief and subtle changes of facial expression remains limited. Here we built on a recently developed paradigm in human electrophysiology with full-blown expressions (Dzhelyova et al., 2017), to isolate and quantify a neural marker for the detection of brief and subtle changes of facial expression. Scalp electroencephalogram (EEG) was recorded from 18 participants during stimulation of a neutral face changing randomly in size at a rapid rate of 6 Hz...
June 16, 2018: NeuroImage
https://www.readbyqxmd.com/read/29912928/a-new-approach-for-incorporating-15n-isotopic-data-into-linear-inverse-ecosystem-models-with-markov-chain-monte-carlo-sampling
#17
Michael R Stukel, Moira Décima, Thomas B Kelly
Oceanographic field programs often use δ15N biogeochemical measurements and in situ rate measurements to investigate nitrogen cycling and planktonic ecosystem structure. However, integrative modeling approaches capable of synthesizing these distinct measurement types are lacking. We develop a novel approach for incorporating δ15N isotopic data into existing Markov Chain Monte Carlo (MCMC) random walk methods for solving linear inverse ecosystem models. We test the ability of this approach to recover food web indices (nitrate uptake, nitrogen fixation, zooplankton trophic level, and secondary production) derived from forward models simulating the planktonic ecosystems of the California Current and Amazon River Plume...
2018: PloS One
https://www.readbyqxmd.com/read/29912374/luteal-phase-anovulatory-follicles-result-in-the-production-of-competent-oocytes-intra-patient-paired-case-control-study-comparing-follicular-versus-luteal-phase-stimulations-in-the-same-ovarian-cycle
#18
Danilo Cimadomo, Alberto Vaiarelli, Silvia Colamaria, Elisabetta Trabucco, Carlo Alviggi, Roberta Venturella, Erminia Alviggi, Ramona Carmelo, Laura Rienzi, Filippo Maria Ubaldi
STUDY QUESTION: Are the mean numbers of blastocysts obtained from sibling cohorts of oocytes recruited after follicular phase and luteal phase stimulations (FPS and LPS) in the same ovarian cycle similar? SUMMARY ANSWER: The cohorts of oocytes obtained after LPS are larger than their paired-FPS-derived cohorts and show a comparable competence, thus resulting in a larger mean number of blastocysts. WHAT IS KNOWN ALREADY: Three theories of follicle recruitment have been postulated to date: (i) the 'continuous recruitment' theory, (ii) the 'single recruitment episode' theory and (iii) the 'wave' theory...
June 15, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29912236/-dual-atrioventricular-nodal-pathways-physiology-arrhythmic-findings-and-electrocardiographic-manifestations
#19
Marcello Costantini, Vincenzo Carbone, Lorenzo Costantini
The atrioventricular (AV) node is an anatomically well-defined structure, conveniently housed in the triangle of Koch. There are two distinct atrial impulse approaches to the AV node, one of which (in the anterior portion of triangle of Koch) has a faster conduction, while the other one (in the posterior portion) has a slower conduction. However, it is not said that such a conductive duality translates into any arrhythmic phenomena. Actually, these arrhythmias are due to an imbalance of the two pathways electrophysiological properties, which does not always exist...
April 2018: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/29911967/from-principles-to-practice-real-world-patient-and-stakeholder-engagement-in-breast-cancer-research
#20
Sarah M Greene, Susan Brandzel, Karen J Wernli
The Patient-Centered Outcomes Research Institute (PCORI) in Washington, DC, has catalyzed a meaningful shift in the composition of research project teams since its initial research funding cycle in 2011. Despite the influx of funding in the research community for patient-centered research, research on how to effectively engage patients and stakeholders in the research process is still relatively nascent. Kaiser Permanente Washington Health Research Institute (KPWHRI) in Seattle, WA, was an early recipient of PCORI research funding and, as of December 2017, has received 8 PCORI research awards totaling nearly $15 million...
June 6, 2018: Permanente Journal
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