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https://www.readbyqxmd.com/read/28214212/primary-multiple-tumor-with-affection-of-the-thyroid-gland-uterus-urinary-bladder-mammary-gland-and-other-organs
#1
А Romaniuk, M Lyndin, V Smiyanov, Vl Sikora, A Rieznik, Y Kuzenko, H Budko, Yu Moskalenko, L Karpenko, Vol Sikora, O Gladchenko
BACKGROUND: Nowadays multiple primary tumor is characterized by growth and development of two or more tumors in one patient. The total world sickness rate ranges from 1% to 37%. The presence of four or more tumors in one patient is rare case and presented as casuistry. CASE PRESENTATION: We showed a case of multiple primary tumor with metahronic lesion of the thyroid, uterus and breast, followed by synchronous benign tumors of the subcutaneous fat, urinary bladder and gallbladder were considered...
January 19, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28208987/bcl6-mrna-expression-level-in-invasive-duct-carcinoma-not-otherwise-specified
#2
Eman Badr, Eman Masoud, Asmaa Gaber Abdou, Marwa Serag Eldien
INTRODUCTION: B-Cell Lymphoma 6 (BCL6) has an oncogenic role in tumourigenesis of various malignancies. It represses genes involved in terminal differentiation and plays complementary role with Signal Transducer and Activator of Transcription 3 (STAT3) in triple-negative breast cancer cellular function. AIM: To evaluate the expression of BCL6 in cancer breast and determine its correlation with the clinico-pathological features including the molecular subtype of breast carcinoma...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28203501/partial-breast-reconstruction-with-goldilocks-technique-after-excision-of-giant-fibroadenoma-a-case-report
#3
Ryan P Ter Louw, Sara B Bruce, Maurice Y Nahabedian
Giant juvenile fibroadenomas are relatively rare, accounting for less than 1% fibroadenomas. Large breast tumors create significant asymmetry and provide unique reconstructive challenges after removal. In this case, we describe a 21-year-old female with delayed presentation of a giant fibroadenoma of the right breast. This represents an unusual presentation of benign breast disease requiring reduction of the skin envelope, extensive glandular resection, lower pole reconstruction, and free nipple grafting to achieve symmetry with the opposite breast...
January 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28192525/a-prospective-study-of-breast-anthropomorphic-measurements-volume-and-ptosis-in-605-asian-patients-with-breast-cancer-or-benign-breast-disease
#4
Nai-Si Huang, Chen-Lian Quan, Miao Mo, Jia-Jian Chen, Ben-Long Yang, Xiao-Yan Huang, Jiong Wu
OBJECTIVES: The current study aims to summarize breast anthropomorphic measurement features in Chinese patients with breast diseases and to investigate their potential correlations with demographic factors. MATERIALS AND METHODS: Fifteen breast anthropomorphic parameters of 605 Chinese female patients were collected prospectively. Breast ptosis status was scaled by two methods and breast volume was calculated according to a modified formula of BREAST-V. RESULTS: Among 1210 breasts, the average breast volume was 340...
2017: PloS One
https://www.readbyqxmd.com/read/28182052/study-of-nuclear-morphometry-on-cytology-specimens-of-benign-and-malignant-breast-lesions-a-study-of-122-cases
#5
Anamika Kashyap, Manjula Jain, Shailaja Shukla, Manoj Andley
BACKGROUND: Breast cancer has emerged as a leading site of cancer among women in India. Fine needle aspiration cytology (FNAC) has been routinely applied in assessment of breast lesions. Cytological evaluation in breast lesions is subjective with a "gray zone" of 6.9-20%. Quantitative evaluation of nuclear size, shape, texture, and density parameters by morphometry can be of diagnostic help in breast tumor. AIMS: To apply nuclear morphometry on cytological breast aspirates and assess its role in differentiating between benign and malignant breast lesions with derivation of suitable cut-off values between the two groups...
January 2017: Journal of Cytology
https://www.readbyqxmd.com/read/28179453/gynaecomastia-in-786-adult-men-clinical-and-biochemical-findings
#6
Mikkel G Mieritz, Peter Christiansen, Martin Blomberg Jensen, Ulla N Joensen, Loa Nordkap, Inge A Olesen, A Kirstine Bang, Anders Juul, Niels Joergensen
Objective - Gynaecomastia is a benign proliferation of glandular tissue of the breast, however, it is an important clinical observation because it can be the first symptom of an underlying disease. Some controversy exists concerning the clinical importance of an in-depth investigation of men who develop gynaecomastia. We hypothesize that a thorough work-up is required in adult men with gynaecomastia. Design- All adult men (n=818) referred to a secondary level andrological department at Rigshospitalet in Copenhagen, Denmark in a four-year period (2008-2011) under the diagnosis of gynaecomastia (ICD-10: N62) were included...
February 8, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28179336/beck-depression-inventory-as-a-predictor-of-long-term-outcome-among-patients-admitted-to-the-breast-cancer-diagnosis-unit-a-25-year-cohort-study-in-finland
#7
Matti Eskelinen, Riika Korhonen, Tuomas Selander, Paula Ollonen
AIM: The Beck Depression Inventory (BDI) is one of the most widely used instruments for measuring the severity of depression. However, there has been no prospective study to investigate the long-term outcome in patients admitted to Breast Cancer Diagnosis Units. PATIENTS AND METHODS: In the Kuopio Breast Cancer Study, women with breast symptoms were evaluated for total BDI score before any diagnostic procedures were carried out. The relapse-free survival (RFS) was calculated from the time of diagnosis to the time of first relapse including local relapse, contralateral breast cancer (BC) or metastatic disease...
2017: Anticancer Research
https://www.readbyqxmd.com/read/28170091/prevalence-of-occult-pre-malignant-or-malignant-pathology-at-the-time-of-uterine-morcellation-for-benign-disease
#8
Emily C Von Bargen, Cara L Grimes, Kavita Mishra, Rui Wang, Miriam J Haviland, Michele R Hacker, Joseph A Carnevale, Alyssa J Estes, Eman A Elkadry
OBJECTIVE: To determine the prevalence of occult pre-malignant or malignant uterine pathology at the time of laparoscopic surgery with open power morcellation for benign gynecologic disease. METHOD: The present multicenter, retrospective cohort study included women who underwent open power morcellation for benign indications between January 1, 2007, and February 28, 2014, at three academic medical centers in the USA. The primary outcome was pre-malignant or malignant pathology at the time of open power morcellation, and was determined from the patients' pathology reports...
February 7, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28155687/subtype-specific-cpg-island-shore-methylation-and-mutation-patterns-in-30-breast-cancer-cell-lines
#9
Heejoon Chae, Sangseon Lee, Kenneth P Nephew, Sun Kim
BACKGROUND: Aberrant epigenetic modifications, including DNA methylation, are key regulators of gene activity in tumorigenesis. Breast cancer is a heterogeneous disease, and large-scale analyses indicate that tumor from normal and benign tissues, as well as molecular subtypes of breast cancer, can be distinguished based on their distinct genomic, transcriptomic, and epigenomic profiles. In this study, we used affinity-based methylation sequencing data in 30 breast cancer cell lines representing functionally distinct cancer subtypes to investigate methylation and mutation patterns at the whole genome level...
December 23, 2016: BMC Systems Biology
https://www.readbyqxmd.com/read/28143431/mammographic-breast-density-and-risk-of-breast-cancer-in-women-with-atypical-hyperplasia-an-observational-cohort-study-from-the-mayo-clinic-benign-breast-disease-bbd-cohort
#10
Robert A Vierkant, Amy C Degnim, Derek C Radisky, Daniel W Visscher, Ethan P Heinzen, Ryan D Frank, Stacey J Winham, Marlene H Frost, Christopher G Scott, Matthew R Jensen, Karthik Ghosh, Armando Manduca, Kathleen R Brandt, Dana H Whaley, Lynn C Hartmann, Celine M Vachon
BACKGROUND: Atypical hyperplasia (AH) and mammographic breast density (MBD) are established risk factors for breast cancer (BC), but their joint contributions are not well understood. We examine associations of MBD and BC by histologic impression, including AH, in a subcohort of women from the Mayo Clinic Benign Breast Disease Cohort. METHODS: Women with a diagnosis of BBD and mammogram between 1985 and 2001 were eligible. Histologic impression was assessed via pathology review and coded as non-proliferative disease (NP), proliferative disease without atypia (PDWA) and AH...
January 31, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28140609/imaging-concordant-benign-mri-guided-vacuum-assisted-breast-biopsy-may-not-warrant-mri-follow-up
#11
Monica L Huang, Megan Speer, Basak E Dogan, Gaiane M Rauch, Rosalind P Candelaria, Beatriz E Adrada, Kenneth R Hess, Wei T Yang
OBJECTIVE: The follow-up of breast lesions with imaging-concordant benign histopathology results on MRI-guided vacuum-assisted biopsy (VAB) is not currently standardized. We determined the false omission rate of breast MRI-guided VAB with benign histopathology (negative results) to assess whether breast MRI follow-up is needed. MATERIALS AND METHODS: The medical records of patients who underwent 9-gauge breast MRI-guided VAB during 2007-2012 were reviewed retrospectively...
January 31, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28139896/cytopathologic-analysis-of-pericardial-effusions-in-116-cases-implications-for-poor-prognosis-in-lung-cancer-patients-with-positive-interpretations
#12
Bing He, Zhen Yang, Peng Zhao, Yu-Jun Li, Ji-Gang Wang
BACKGROUND: Few studies have evaluated the cytology of pericardial effusions. The aim of this study is to investigate the etiologies of pericardial effusions and to establish the relationship between cytopathologic interpretations and outcome patterns among patients with pericardial effusions. METHODS: We identified 116 patients with pericardial effusions at a single institution over a 4-year period and carefully analyzed all available clinical documents, including clinical diagnoses, cytopathologic findings, and outcome patterns...
January 31, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28133886/somatic-snps-of-the-brca2-gene-at-the-fragments-encoding-rad51-binding-sites-of-canine-mammary-tumors
#13
O Ozmen, S Kul, A Risvanli, G Ozalp, A Sabuncu, O Kul
Mammary tumors are the most common tumor type both in women and in female dogs. In women, heritable breast cancers have been linked mutations in the breast cancer susceptibility gene BRCA2 and it contains eight BRC repeats in exon 11 that bind to RAD51. In this study, we investigated the sequence variations of BRC1-BRC8 and C-terminus of canine BRCA2 gene. From a total of 64 canine patients with mammary tumors, 31 mammary tumors with benign and malign carcinomas and the 3 normal mammary glands were used for the study...
January 30, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/28133211/-a-case-of-inflammatory-pseudotumor-of-the-mammary-gland
#14
Wataru Goto, Shinichiro Kashiwagi, Koji Takada, Yuka Asano, Tamami Morisaki, Tsutomu Takashima, Satoru Noda, Naoyoshi Onoda, Masahiko Ohsawa, Kosei Hirakawa, Masaichi Ohira
A 52-year-old woman visited our hospital with a chief complaint of a mass in the left breast. Palpation revealed a mass approximately 3 cm in diameter located on the outer aspect of the left breast. Breast ultrasound revealed a hypoechoic area with an indistinct border, which suggested breast cancer or mastitis. A needle biopsy revealed no evidence of malignancy, and granulomatous mastitis was diagnosed. Antibiotic therapy showed no improvement; therefore, we began prednisolone treatment for the patient. The mass diameter decreased over the subsequent 5 months after initiating this treatment, and we decreased the dose of prednisolone gradually...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28126725/alterations-in-the-immune-cell-composition-in-premalignant-breast-tissue-that-precede-breast-cancer-development
#15
Amy C Degnim, Tanya L Hoskin, Muhammad Arshad, Marlene H Frost, Stacey J Winham, Rushin Brahmbhatt, Alvaro Pena, Jodi M Carter, Melody Stallings-Mann, Linda Murphy, Erin Miller, Lori Denison, Celine M Vachon, Keith L Knutson, Derek C Radisky, Daniel W Visscher
Purpose Little is known about the role of the immune system in the earliest stages of breast carcinogenesis. We studied quantitative differences in immune cell types between breast tissues from normal donors and women with benign breast disease (BBD). Design A breast tissue matched case-control study was created from donors to the Susan G. Komen® for the Cure Tissue Bank (KTB), and from women diagnosed with BBD at Mayo Clinic who either subsequently developed cancer (BBD cases) or remained cancer-free (BBD controls)...
January 26, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28109290/characterizing-breast-conditions-at-an-open-access-breast-clinic-in-south-africa-a-model-that-is-more-than-cancer-care-for-a-resource-limited-setting
#16
Sarah Rayne, Naomi Lince-Deroche, Cheryl Hendrickson, Kate Shearer, Faith Moyo, Pam Michelow, Grace Rubin, Carol Benn, Cynthia Firnhaber
BACKGROUND: While most breast-related research focuses on cancer, presentation of symptomatic persons in non-screened environments requires understanding the spectrum of breast diseases so as to plan services in resource-constrained settings. This study presents the variety of breast disease managed at a government, open-access breast clinic in South Africa. METHODS: We performed a retrospective file review using a systematic random sample of patients 18 years and above presenting for breast care over a 14-month period...
January 21, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28105221/aberrant-promoter-methylation-of-cancer-related-genes-in-human-breast-cancer
#17
Liang Wu, Ye Shen, Xianzhen Peng, Simin Zhang, Ming Wang, Guisheng Xu, Xianzhi Zheng, Jianming Wang, Cheng Lu
The clinical relevance of aberrant DNA methylation is being increasingly recognized in breast cancer. The present study aimed to evaluate the promoter methylation status of seven candidate genes and to explore their potential use as a biomarker for the diagnosis of breast cancer. A total of 70 Chinese patients with breast cancer were recruited, and matched with 20 patients with benign breast disease (BBD). Methylation-specific polymerase chain reaction was performed to measure the methylation status of selected genes...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28103010/a-fluorescent-hsp90-probe-demonstrates-the-unique-association-between-extracellular-hsp90-and-malignancy-in-vivo
#18
Lauren B Crowe, Philip F Hughes, David A Alcorta, Takuya Osada, Aaron P Smith, Juliane Totzke, David R Loiselle, Isaac D Lutz, Madhusudhana Gargesha, Debasish Roy, Jose Roques, David Darr, H Kim Lyerly, Neil L Spector, Timothy Aj Haystead
Extracellular expression of heat shock protein 90 (eHsp90) by tumor cells is correlated with malignancy. Development of small molecule probes that can detect eHsp90 in vivo may therefore have utility in the early detection of malignancy. We synthesized a cell impermeable far-red fluorophore-tagged Hsp90 inhibitor to target eHsp90 in vivo. High resolution confocal and lattice light sheet microscopy show that probe-bound eHsp90 accumulates in punctate structures on the plasma membrane of breast tumor cells and is actively internalized...
January 19, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28091804/baseline-results-from-the-uk-signify-study-a-whole-body-mri-screening-study-in-tp53-mutation-carriers-and-matched-controls
#19
Sibel Saya, Emma Killick, Sarah Thomas, Natalie Taylor, Elizabeth K Bancroft, Jeanette Rothwell, Sarah Benafif, Alexander Dias, Christos Mikropoulos, Jenny Pope, Anthony Chamberlain, Ranga Gunapala, Louise Izatt, Lucy Side, Lisa Walker, Susan Tomkins, Jackie Cook, Julian Barwell, Vicki Wiles, Lauren Limb, Diana Eccles, Martin O Leach, Susan Shanley, Fiona J Gilbert, Helen Hanson, David Gallagher, Bala Rajashanker, Richard W Whitehouse, Dow-Mu Koh, S Aslam Sohaib, D Gareth Evans, Rosalind A Eeles
In the United Kingdom, current screening guidelines for TP53 germline mutation carriers solely recommends annual breast MRI, despite the wide spectrum of malignancies typically seen in this group. This study sought to investigate the role of one-off non-contrast whole-body MRI (WB MRI) in the screening of asymptomatic TP53 mutation carriers. 44 TP53 mutation carriers and 44 population controls were recruited. Scans were read by radiologists blinded to participant carrier status. The incidence of malignancies diagnosed in TP53 mutation carriers against general population controls was calculated...
January 16, 2017: Familial Cancer
https://www.readbyqxmd.com/read/28079297/the-effectiveness-of-diclofenac-sodium-in-the-treatment-of-mondor-s-disease-of-the-breast-the-topical-patch-compared-to-the-oral-capsules
#20
Bader Hamza Shirah, Hamza Assad Shirah, Wedad Salem Alonazie
Mondor's disease of the breast is a rare, benign sclerosing superficial thrombophlebitis of the subcutaneous veins of the anterior or lateral chest wall, which is treated conservatively. We aim in this study to evaluate the outcome and effectiveness of our treatment protocol using oral diclofenac sodium and topical diclofenac sodium patch in 172 patients. A retrospective database analysis of 172 female patients between January 2001 and December 2010 was done. The treatment protocol consisted of group 1: treatment by oral diclofenac sodium 100 mg once daily for 3 weeks...
January 12, 2017: Breast Journal
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