keyword
MENU ▼
Read by QxMD icon Read
search

benign breast disease

keyword
https://www.readbyqxmd.com/read/28105221/aberrant-promoter-methylation-of-cancer-related-genes-in-human-breast-cancer
#1
Liang Wu, Ye Shen, Xianzhen Peng, Simin Zhang, Ming Wang, Guisheng Xu, Xianzhi Zheng, Jianming Wang, Cheng Lu
The clinical relevance of aberrant DNA methylation is being increasingly recognized in breast cancer. The present study aimed to evaluate the promoter methylation status of seven candidate genes and to explore their potential use as a biomarker for the diagnosis of breast cancer. A total of 70 Chinese patients with breast cancer were recruited, and matched with 20 patients with benign breast disease (BBD). Methylation-specific polymerase chain reaction was performed to measure the methylation status of selected genes...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28103010/a-fluorescent-hsp90-probe-demonstrates-the-unique-association-between-extracellular-hsp90-and-malignancy-in-vivo
#2
Lauren B Crowe, Philip F Hughes, David A Alcorta, Takuya Osada, Aaron P Smith, Juliane Totzke, David R Loiselle, Isaac D Lutz, Madhusudhana Gargesha, Debasish Roy, Jose Roques, David Darr, H Kim Lyerly, Neil L Spector, Timothy Aj Haystead
Extracellular expression of heat shock protein 90 (eHsp90) by tumor cells is correlated with malignancy. Development of small molecule probes that can detect eHsp90 in vivo may therefore have utility in the early detection of malignancy. We synthesized a cell impermeable far-red fluorophore-tagged Hsp90 inhibitor to target eHsp90 in vivo. High resolution confocal and lattice light sheet microscopy show that probe-bound eHsp90 accumulates in punctate structures on the plasma membrane of breast tumor cells and is actively internalized...
January 19, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28091804/baseline-results-from-the-uk-signify-study-a-whole-body-mri-screening-study-in-tp53-mutation-carriers-and-matched-controls
#3
Sibel Saya, Emma Killick, Sarah Thomas, Natalie Taylor, Elizabeth K Bancroft, Jeanette Rothwell, Sarah Benafif, Alexander Dias, Christos Mikropoulos, Jenny Pope, Anthony Chamberlain, Ranga Gunapala, Louise Izatt, Lucy Side, Lisa Walker, Susan Tomkins, Jackie Cook, Julian Barwell, Vicki Wiles, Lauren Limb, Diana Eccles, Martin O Leach, Susan Shanley, Fiona J Gilbert, Helen Hanson, David Gallagher, Bala Rajashanker, Richard W Whitehouse, Dow-Mu Koh, S Aslam Sohaib, D Gareth Evans, Rosalind A Eeles
In the United Kingdom, current screening guidelines for TP53 germline mutation carriers solely recommends annual breast MRI, despite the wide spectrum of malignancies typically seen in this group. This study sought to investigate the role of one-off non-contrast whole-body MRI (WB MRI) in the screening of asymptomatic TP53 mutation carriers. 44 TP53 mutation carriers and 44 population controls were recruited. Scans were read by radiologists blinded to participant carrier status. The incidence of malignancies diagnosed in TP53 mutation carriers against general population controls was calculated...
January 16, 2017: Familial Cancer
https://www.readbyqxmd.com/read/28079297/the-effectiveness-of-diclofenac-sodium-in-the-treatment-of-mondor-s-disease-of-the-breast-the-topical-patch-compared-to-the-oral-capsules
#4
Bader Hamza Shirah, Hamza Assad Shirah, Wedad Salem Alonazie
Mondor's disease of the breast is a rare, benign sclerosing superficial thrombophlebitis of the subcutaneous veins of the anterior or lateral chest wall, which is treated conservatively. We aim in this study to evaluate the outcome and effectiveness of our treatment protocol using oral diclofenac sodium and topical diclofenac sodium patch in 172 patients. A retrospective database analysis of 172 female patients between January 2001 and December 2010 was done. The treatment protocol consisted of group 1: treatment by oral diclofenac sodium 100 mg once daily for 3 weeks...
January 12, 2017: Breast Journal
https://www.readbyqxmd.com/read/28076009/delineating-extramammary-findings-at-breast-mr-imaging
#5
Yiming Gao, Opeyemi Ibidapo, Hildegard K Toth, Linda Moy
Breast magnetic resonance (MR) imaging is the only breast imaging modality that consistently encompasses extramammary structures in the thorax and upper abdomen. Incidental extramammary findings on breast MR images of patients with a history of breast cancer or other malignancies are significantly more likely to be malignant and may affect staging and treatment. An understanding of the frequency, distribution, and context of extramammary findings on breast MR images and a familiarity with common and uncommon sites of breast cancer metastasis inform the differential diagnosis and prompt the appropriate diagnostic next step, to differentiate benign from malignant findings...
January 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28062981/body-size-from-birth-through-adolescence-in-relation-to-risk-of-benign-breast-disease-in-young-women
#6
Catherine S Berkey, Bernard Rosner, Rulla M Tamimi, Walter C Willett, Martha Hickey, Adetunji Toriola, A Lindsay Frazier, Graham A Colditz
PURPOSE: Body size, from birth throughout adulthood, is associated with breast cancer risk, but few studies have investigated early-life body size and benign breast disease (BBD), a well-established breast cancer risk factor. We consider whether prenatal factors and size at birth, 10, 18 year, and intervening growth, are related to BBD risk. METHODS: The Growing Up Today Study includes 9032 females who completed questionnaires annually from 1996 to 2001, then 2003, 2005, 2007, 2010, and 2013...
January 6, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28058550/do-calcifications-seen-on-mammography-after-neoadjuvant-chemotherapy-for-breast-cancer-always-need-to-be-excised
#7
Yara Feliciano, Anita Mamtani, Monica Morrow, Michelle M Stempel, Sujata Patil, Maxine S Jochelson
BACKGROUND: This study aimed to determine the relationship between mammographic calcifications and magnetic resonance imaging (MRI) tumoral enhancement before and after neoadjuvant chemotherapy (NAC) and to assess the impact of these findings on surgical management. METHODS: This Institutional Review Board-approved, Health Insurance Portability and Accountability Act (HIPAA)-compliant retrospective study involved breast cancer patients who underwent NAC between 2009 and 2015...
January 5, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28053629/predictive-factors-for-upgrading-patients-with-benign-breast-papillary-lesions-using-a-core-needle-biopsy
#8
Young Ran Hong, Byung Joo Song, Sang Seol Jung, Bong Joo Kang, Sung Hun Kim, Byung Joo Chae
PURPOSE: Intraductal papilloma (IDP) is a benign breast disease with malignant potential, for which complete surgical excision is usually recommended. The aim of the present study was to investigate predictive factors for upgrading patients with a benign papillary lesion (BPL). METHODS: This study was an observational study using a prospectively collected cohort. In total, 13,049 patients who underwent a core needle biopsy (CNB) for a breast lesion between January 2009 and May 2015 were enrolled...
December 2016: Journal of Breast Cancer
https://www.readbyqxmd.com/read/28049216/cancer-implications-for-patients-with-endometriosis
#9
Mary Ann Wilbur, Ie-Ming Shih, James H Segars, Amanda N Fader
Endometriosis is defined as the presence of viable endometrial glands and stroma outside of the uterus. It is a common disease, occurring in 5 to 15% of all women. Endometriosis is associated with chronic pelvic pain and infertility and often requires surgical intervention for definitive treatment. Although it is a benign gynecologic condition, endometriosis shares pathophysiologic features with cancer. In recent years, both histologic and epidemiologic evidence has accumulated, suggesting that ovarian endometriosis may give rise to malignant ovarian tumors, primarily those that are epithelial in origin, known as endometriosis-associated ovarian carcinoma (EAOC) including ovarian clear cell carcinoma, endometrioid carcinoma, and the least common, seromucinous tumors...
January 3, 2017: Seminars in Reproductive Medicine
https://www.readbyqxmd.com/read/28044958/bilateral-axillary-accessory-breast-tissue-revealed-by-pregnancy
#10
Florin Grama, Ștefan Voiculescu, Ema Vîrga, Traean Burcoş, Daniel Cristian
We illustrate a rare case of a 28 year-old woman with bilateral axillary masses, which were uncovered during her first pregnancy only and grew progresively in size ever since. On local examination, there were two 5/3/5 cm masses with benign clinical characteristics, developed apparently on the axillary extension of the mammary gland. During lactation, a milk-like liquid was evacuated through a brownish, rudimentary, nipple located in the center of each axillary masses. One year after parturition, the MRI showed bilateral axillary breast tissue appearance, separated from the eutopic mammary gland, but having similar signal intensity...
November 2016: Chirurgia
https://www.readbyqxmd.com/read/28040694/risk-factors-that-increase-risk-of-estrogen-receptor-positive-and-negative-breast-cancer
#11
Karla Kerlikowske, Charlotte C Gard, Jeffrey A Tice, Elad Ziv, Steven R Cummings, Diana L Miglioretti
BACKGROUND: Risk factors may differentially influence development of estrogen receptor (ER)-positive vs -negative breast cancer. We examined associations with strong, prevalent risk factors by ER subtype. METHODS: Of 1 279 443 women age 35 to 74 years participating in the Breast Cancer Surveillance Consortium, 14 969 developed ER-positive and 3617 developed ER-negative invasive breast cancer. We calculated hazard ratios (HRs) using Cox regression and compared ER subtype hazard ratios at representative ages or by menopausal status using Wald tests...
May 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28018765/effect-of-multidisciplinary-case-conferences-on-physician-decision-making-breast-diagnostic-rounds
#12
Tianne J Foster, Antoine Bouchard-Fortier, Ivo A Olivotto, May Lynn Quan
PURPOSE: To evaluate the utility of multidisciplinary case conferences (MCCs) on physician decision making in benign and malignant breast disease management. METHODS:  Patients with interesting or challenging diagnostic or management issues were discussed at biweekly diagnostic breast MCCs. Prior to discussion, a clinical summary and intended management plan prior to the MCC was presented. For each case, diagnostic images/histopathology were centrally reviewed after which group discussion achieved a management consensus which was documented prospectively...
November 24, 2016: Curēus
https://www.readbyqxmd.com/read/28006062/association-between-benign-breast-disease-in-african-american-and-white-american-women-and-subsequent-triple-negative-breast-cancer
#13
Lisa A Newman, Azadeh Stark, Dhanajay Chitale, Margaret Pepe, Gary Longton, Maria J Worsham, S David Nathanson, Patricia Miller, Jessica M Bensenhaver, Erica Proctor, Monique Swain, Christos Patriotis, Paul F Engstrom
Importance: Compared with white American (WA) women, African American (AA) women have a 2-fold higher incidence of breast cancers that are negative for estrogen receptor, progesterone receptor, and ERBB2 (triple-negative breast cancer [TNBC]). Triple-negative breast cancer, compared with non-TNBC, likely arises from different pathogenetic pathways, and benign breast disease (BBD) predicts future non-TNBC. Objective: To determine whether AA identity remains associated with TNBC for women with a prior diagnosis of BBD...
December 22, 2016: JAMA Oncology
https://www.readbyqxmd.com/read/28003316/projecting-individualized-absolute-invasive-breast-cancer-risk-in-us-hispanic-women
#14
Matthew P Banegas, Esther M John, Martha L Slattery, Scarlett Lin Gomez, Mandi Yu, Andrea Z LaCroix, David Pee, Rowan T Chlebowski, Lisa M Hines, Cynthia A Thompson, Mitchell H Gail
BACKGROUND: There is no model to estimate absolute invasive breast cancer risk for Hispanic women. METHODS: The San Francisco Bay Area Breast Cancer Study (SFBCS) provided data on Hispanic breast cancer case patients (533 US-born, 553 foreign-born) and control participants (464 US-born, 947 foreign-born). These data yielded estimates of relative risk (RR) and attributable risk (AR) separately for US-born and foreign-born women. Nativity-specific absolute risks were estimated by combining RR and AR information with nativity-specific invasive breast cancer incidence and competing mortality rates from the California Cancer Registry and Surveillance, Epidemiology, and End Results program to develop the Hispanic risk model (HRM)...
February 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28000465/difference-in-fatty-acids-composition-of-breast-adipose-tissue-in-women-with-breast-cancer-and-benign-breast-disease
#15
Lisiane Lopes da Conceição, Mariana De Moura Dias, Milene Cristine Pessoa, Geórgia Das Graças Pena, Maria Carolina Santos Mendes, Cristiane Vilas Boas Neves, Helen Hermana Miranda Hermsdorff, Renata Nascimento Freitas, Maria do Carmo Gouveia Peluzio
INTRODUCTION: Breast cancer is the second most common cancer in the world, and the most frequent cancer among women. Moreover, there are factors that influence the risk for breast cancer including the age, genetic and endocrine factors, and lifestyle. OBJECTIVES: To evaluate the consumption of fatty acids; compare the fatty acids composition in the breast adipose tissue of women with breast cancer and benign breast disease as well as potential risk factors; and describe the genotypic frequency of the Pro12Ala PPARγ polymorphism...
November 29, 2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/27977584/impact-of-lifestyle-and-psychological-stress-on-the-development-of-early-onset-breast-cancer
#16
Ping Li, Jialing Huang, Huina Wu, Cuixia Fu, Yun Li, Jiajia Qiu
The present study aimed to investigate risk factors for early onset breast cancer that are related to lifestyle and psychological stress. A comparative case-control study was performed among patients from the Department of Breast Surgery in Shanghai Cancer Center of Fudan University. The information regarding risk factors associated with the development of early onset breast cancer was collected using a questionnaire in a face-to-face interview. The distribution of the risk factors associated with the development of early onset breast cancer between the patient group and the control group was analyzed with logistic regression...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27966929/combined-docking-and-quantum-chemical-study-on-cyp-mediated-metabolism-of-estrogens-in-man
#17
Anikó Lábas, Balázs Krámos, Julianna Oláh
Long-term exposure to estrogens seriously increases the incidence of various diseases including breast cancer. Experimental studies indicate that cytochrome P450 (CYP) enzymes catalyze the bioactivation of estrogens to catechols, which can exert their harmful effects via various routes. It has been shown that the 4-hydroxylation pathway of estrogens is the most malign, while 2-hydroxylation is considered a benign pathway. It is also known experimentally that with increasing unsaturation of ring B of estrogens the prevalence of the 4-hydroxylation pathway significantly increases...
December 14, 2016: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/27943004/carney-complex-a-familial-lentiginosis-predisposing-to-a-variety-of-tumors
#18
REVIEW
Constantine A Stratakis
Carney complex is a familial lentiginosis syndrome; these disorders cover a wide phenotypic spectrum ranging from a benign inherited predisposition to develop cutaneous spots not associated with systemic disease to associations with several syndromes. Carney complex is caused by PRKAR1A mutations and perturbations of the cyclic AMP-dependent protein kinase (PKA) signaling pathway. In addition to the cutaneous findings, the main tumors associated with Carney complex are endocrine: 1) primary pigmented nodular adrenocortical disease, a bilateral adrenal hyperplasia leading to Cushing syndrome; 2) growth-hormone secreting pituitary adenoma or pituitary somatotropic hyperplasia leading to acromegaly; 3) thyroid and gonadal tumors, including a predisposition to thyroid cancer...
September 2016: Reviews in Endocrine & Metabolic Disorders
https://www.readbyqxmd.com/read/27936420/myofibroblastoma-of-the-male-breast-a-rare-entity-with-radiologic-pathologic-correlation
#19
John D Comer, Xiaoyan Cui, Carolyn Sharyn Eisen, Genevieve Abbey, Elizabeth Kagan Arleo
A 73-year old man with a history of multiple genitourinary malignancies was found to have a left retroareolar soft tissue mass on CT assessment of disease, and dedicated breast imaging was recommended. Diagnostic mammography and ultrasonography confirmed a solid mass, for which biopsy was recommended. Pathologic analysis demonstrated a spindle cell neoplasm with an immunoreactivity pattern consistent with myofibroblastoma. While this entity is benign, nonspecific imaging features necessitate tissue sampling for pathologic diagnosis, and, given pathologic rarity, open communication between the radiologist and pathologist is important to establish the correct diagnosis and to recommend appropriate management...
November 30, 2016: Clinical Imaging
https://www.readbyqxmd.com/read/27925648/sonographic-evaluation-of-intrathyroid-metastases
#20
J Matthew Debnam, Michael Kwon, Bruno D Fornage, Savitri Krishnamurthy, Gary L Clayman, Beth S Edeiken-Monroe
OBJECTIVES: Intrathyroid metastases from extrathyroid primary tumors are rare. Clinical findings may be subtle, but detection of intrathyroid metastases has improved with sonography. The objective of this study was to evaluate the sonographic appearance of intrathyroid metastases. METHODS: Patients with thyroid masses with cytopathologic features matching those of an extrathyroid primary tumor were retrospectively identified. The appearances of intrathyroid metastases on sonography were reviewed for the following features: size, margin regularity, echogenicity, echotexture, vascularity on power or color Doppler ultrasonography, and the presence or absence of any associated cervical adenopathy...
January 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
keyword
keyword
74677
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"