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Early-Onset Scoliosis

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https://www.readbyqxmd.com/read/28777282/intrawound-vancomycin-powder-associated-with-reduced-surgical-site-infection-in-rib-based-distraction-surgery
#1
Justin M Haller, John A Heflin, David A Hulet, Qian Ding, Angela P Presson, John T Smith
BACKGROUND: Despite clinical reports of improved pulmonary function and reduced spinal deformity with rib-based distraction surgery in early-onset scoliosis (EOS) patients, infection remains a common complication, reported as high as 32% in some studies. The purpose of this study was to evaluate intrawound vancomycin powder in pediatric patients managed with rib-based distraction for EOS. METHODS: This was a single institution retrospective cohort study of EOS patients treated with rib-based distraction...
August 2, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28757364/ehlers-danlos-syndrome-kyphoscoliotic-type-due-to-lysyl-hydroxylase-1-deficiency-in-two-children-without-congenital-or-early-onset-kyphoscoliosis
#2
Fleur S van Dijk, Grazia M S Mancini, Alessandra Maugeri, Jan M Cobben
We report two children with Ehlers Danlos, kyphoscoliotic type confirmed by Lysyl Hydroxylase 1 deficiency due to bi-allelic PLOD1 mutations (kEDS-PLOD1) who were initially thought to have either a diagnosis of classical EDS (cEDS) or a neuromuscular disorder due to absence of (congenital) scoliosis. As the two patients reported here illustrate, patients with kEDS-PLOD1 do not always have a kyphoscoliosis present at birth or in the first year of life, neither do they necessarily develop kyphoscoliosis later in infancy...
July 27, 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/28687252/treatment-of-early-onset-scoliosis-with-a-hybrid-of-a-concave-magnetic-driver-magnetic-controlled-growth-rod-and-a-contralateral-passive-sliding-rod-construct-with-apical-control-preliminary-report-on-17-cases
#3
Simon T Skov, Sebastiaan P J Wijdicks, Cody Bünger, René M Castelein, Haisheng Li, Moyo C Kruyt
BACKGROUND CONTEXT: Magnetic controlled growth rods (MCGRs) are increasingly popular for surgical treatment of severe early-onset scoliosis (EOS), because they allow noninvasive extensions with good growth maintenance. We combined an MCGR with a contralateral passive sliding rod construct with apical control on the convex side to improve efficiency in terms of costs and three-dimensional (3D) correction. PURPOSE: To investigate the feasibility, 3D correction, spinal growth, and complications of the apical control MCGR sliding rod hybrid...
July 4, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28671878/application-of-low-dose-stereoradiography-in-in-vivo-vertebral-morphologic-measurements-comparison-with-computed-tomography
#4
Saba Pasha, Tom Schlösser, Xiaowei Zhu, Xochitl Mellor, René Castelein, John Flynn
BACKGROUND: Though computed tomography (CT) and 3 dimensional (3D) reconstruction of the spine and ribcage are powerful techniques for detailed monitoring of spinal growth and surgical planning of patients, drawbacks can arise. We explored the application of low-dose stereoradiography of the spine to calculate distinct morphologic parameters of the vertebral body in a juvenile patient population with early-onset scoliosis or congenital scoliosis. This study compares the 3D vertebral morphology measurements using low-dose stereoradiography with the currently accepted imaging modality for such measurements, CT scans...
June 30, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28665821/spine-and-thoracic-height-measurements-have-excellent-interrater-and-intrarater-reliability-in-patients-with-early-onset-scoliosis
#5
Nicole Michael, Patrick Carry, Mark Erickson, Nikki Bloch, Steven Gibbons, Courtney O'Donnell, Sumeet Garg
STUDY DESIGN: Reproducibility of measurements OBJECTIVE.: This study investigates the reliability and standard error of measurement of spine and thoracic height radiographic measurements in patients with early onset scoliosis (EOS). SUMMARY OF BACKGROUND DATA: Spine and thoracic height radiographic measurements are often used as a surrogate for pulmonary development in patients with EOS. There is limited literature validating the reliability of spine and thoracic height measurements in the EOS population...
June 29, 2017: Spine
https://www.readbyqxmd.com/read/28660205/pneumothoraces-in-collagen-vi-related-dystrophy-a-case-series-and-recommendations-for-management
#6
Kristin L Fraser, Scott Wong, A Reghan Foley, Sameer Chhibber, Carsten G Bönnemann, Daniel J Lesser, Carla Grosmann, Anne Rutkowski
Collagen VI-related dystrophy (collagen VI-RD) is a rare neuromuscular condition caused by mutations in the COL6A1, COL6A2 or COL6A3 genes. The phenotypic spectrum includes early-onset Ullrich congenital muscular dystrophy, adult-onset Bethlem myopathy and an intermediate phenotype. The disorder is characterised by distal hyperlaxity and progressive muscle weakness, joint contractures and respiratory insufficiency. Respiratory insufficiency is attributed to chest wall contractures, scoliosis, impaired diaphragmatic function and intercostal muscle weakness...
April 2017: ERJ Open Research
https://www.readbyqxmd.com/read/28658035/unplanned-reoperations-in-magnetically-controlled-growing-rod-surgery-for-early-onset-scoliosis-with-a-minimum-of-two-year-follow-up
#7
Kenny Yat Hong Kwan, Ahmet Alanay, Muharrem Yazici, Gokhan Demirkiran, Ilkka Helenius, Colin Nnadi, John Ferguson, Behrooz A Akbarnia, Jason Pui Yin Cheung, Kenneth M C Cheung
STUDY DESIGN: A retrospective review of prospectively collected clinical and radiologic data of patients with magnetically controlled growing rods (MCGR) from a multi-centred study with a minimum of 2 year follow-up. OBJECTIVE: To describe the incidence and causes of unplanned reoperations and to report the outcomes of patients treated with MCGR for early-onset scoliosis (EOS). SUMMARY OF BACKGROUND DATA: Published clinical studies have demonstrated that MCGR is safe and effective for curvature control of EOS, and can avoid repeated surgeries for distractions...
June 27, 2017: Spine
https://www.readbyqxmd.com/read/28645460/associations-between-timing-of-corticosteroid-treatment-initiation-and-clinical-outcomes-in-duchenne-muscular-dystrophy
#8
Sunkyung Kim, Yong Zhu, Paul A Romitti, Deborah J Fox, Daniel W Sheehan, Rodolfo Valdez, Dennis Matthews, Brent J Barber
The long-term efficacy of corticosteroid treatment and timing of treatment initiation among Duchenne muscular dystrophy (DMD) patients is not well-understood. We used data from a longitudinal, population-based DMD surveillance program to examine associations between timing of treatment initiation (early childhood [before or at age 5 years], late childhood [after age 5 years], and naïve [not treated]) and five clinical outcomes (age at loss of ambulation; ages at onset of cardiomyopathy, scoliosis, and first fracture; and pulmonary function)...
June 5, 2017: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/28632593/functional-and-radiographic-outcomes-following-growth-sparing-management-of-early-onset-scoliosis
#9
Charles E Johnston, Dong-Phuong Tran, Anna McClung
BACKGROUND: In this study, we sought to evaluate radiographic, functional, and quality-of-life outcomes of patients who have completed growth-sparing management of early-onset scoliosis. METHODS: This prospective study involved patients with early-onset scoliosis who underwent growth-sparing treatment and either "final" fusion or observation for ≥2 years since the last lengthening procedure. Demographics, radiographic parameters, pulmonary function test (PFT) values, and scores of patient-reported assessments (Early-Onset Scoliosis Questionnaire [EOSQ] and Scoliosis Research Society [SRS]-30) were obtained...
June 21, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28622904/radiographic-outcomes-of-shilla-growth-guidance-system-and-traditional-growing-rods-through-definitive-treatment
#10
Scott J Luhmann, June C Smith, Ann McClung, Frances L McCullough, Richard E McCarthy, George H Thompson
STUDY DESIGN: Retrospective review of a multicenter database. OBJECTIVES: To compare the radiographic outcomes of patients who had undergone the Shilla Growth Guidance System (SGGS) and traditional growing rod (GR) treatment for management of early-onset scoliosis (EOS) through definitive treatment. SUMMARY OF BACKGROUND DATA: The efficacy of surgical treatment of EOS can only be determined after definitive treatment has been completed. We wanted to review our experience with the SGGS and GR for management of EOS through definitive treatment...
July 2017: Spine Deformity
https://www.readbyqxmd.com/read/28614286/three-dimensional-true-spine-length-a-novel-technique-for-assessing-the-outcomes-of-scoliosis-surgery
#11
Alan J Spurway, Jennifer K Hurry, Luke Gauthier, Ben Orlik, Chukwudi K Chukwunyerenwa, Waleed E Kishta, Ron El-Hawary
BACKGROUND: Current assessment of spine growth for patients undergoing growth friendly surgical treatment for early-onset scoliosis (EOS) is the use of serial, 1-dimensional standard-of-care coronal vertical spine height (SoCVH) measurements. Any growth of the spine out of the coronal plane is missed by the SoCVH, which may underestimate the actual growth of the spine. This study set to validate the novel 3-dimensional true spine length (3DTSL) radiographic measurement technique for measuring growth of EOS patients...
June 13, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28604490/health-related-quality-of-life-in-early-onset-scoliosis-patients-treated-surgically-eosq-scores-in-traditional-growing-rod-vs-magnetically-controlled-growing-rods
#12
Michael E Doany, Z Deniz Olgun, Gizem Irem Kinikli, Senol Bekmez, Aykut Kocyigit, Gokhan Demirkiran, A Ergun Karaagaoglu, Muharrem Yazici
STUDY DESIGN: Cross-sectional study. OBJECTIVE: To compare quality of life and caregiver burden in TGR and MCGR patients. SUMMARY OF BACKGROUND DATA: Magnetic controlled growing rods (MCGR) decrease surgical sessions associated with treatment of early onset scoliosis (EOS), hoping to minimize the burdens seen with repetitive invasive surgeries in traditional growing rod (TGR) treatment. Although the clinical indications for these treatments have largely been agreed upon, there is a lack of understanding of their impact on patients' and families' quality of life...
June 9, 2017: Spine
https://www.readbyqxmd.com/read/28582331/short-segment-spinal-instrumentation-in-early-onset-scoliosis-patients-treated-with-magnetically-controlled-growing-rods-surgical-technique-and-mid-short-term-outcomes
#13
Ahmed Majid Heydar, Serdar Şirazi, Erhan Okay, Murat Bezer
STUDY DESIGN: Prospective, a single institution, non-randomized study. OBJECTIVE: To evaluate the safety and effectivity of short-segment instrumentation in early onset scoliosis (EOS) patients treated by magnetic controlled growing rods (MCGR). SUMMERY OF BACKGROUND DATA: Despite the common use of conventional growing rods and the recent popularity of MCGR in the treatment of progressive EOS, distal instrumented vertebra and number of the spanned levels are not standardized...
June 2, 2017: Spine
https://www.readbyqxmd.com/read/28566405/intraspinal-anomalies-in-early-onset-idiopathic-scoliosis
#14
E A C Pereira, M Oxenham, K S Lam
AIMS: In the United Kingdom, lower incidences of intraspinal abnormalities in patients with early onset idiopathic scoliosis have been observed than in studies in other countries. We aimed to determine the rates of these abnormalities in United Kingdom patients diagnosed with idiopathic scoliosis before the age of 11 years. PATIENTS AND METHODS: This retrospective study of patients attending an urban scoliosis clinic identified 71 patients satisfying a criteria of: clinical diagnosis of idiopathic scoliosis; age of onset ten years and 11 months or less; MRI screening for intraspinal abnormalities...
June 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28566388/magnetically-controlled-growing-rods-in-the-treatment-of-early-onset-scoliosis-a-note-of-caution
#15
P R P Rushton, I Siddique, R Crawford, N Birch, M J Gibson, M J Hutton
The MAGnetic Expansion Control (MAGEC) system is used increasingly in the management of early-onset scoliosis. Good results have been published, but there have been recent reports identifying implant failures that may be associated with significant metallosis surrounding the implants. This article aims to present the current knowledge regarding the performance of this implant, and the potential implications and strategies that may be employed to identify and limit any problems. We urge surgeons to apply caution to patient and construct selection; engage in prospective patient registration using a spine registry; ensure close clinical monitoring until growth has ceased; and send all explanted MAGEC rods for independent analysis...
June 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28498293/what-is-the-actual-3d-representation-of-the-rib-vertebra-angle-difference-mehta-s-angle
#16
Rob C Brink, Tom P C Schlösser, Marijn van Stralen, Koen L Vincken, Moyo C Kruyt, Winnie C W Chu, Jack C Y Cheng, René M Castelein
STUDY DESIGN: Cross-sectional study. OBJECTIVE: To establish the relevance of the conventional two-dimensional (2D) RVAD and the relationship with the complex three-dimensional (3D) apical morphology in scoliosis. SUMMARY OF BACKGROUND DATA: The rib vertebra angle difference (RVAD, also known as Mehta's angle) describes apical rib asymmetry on conventional radiographs and was introduced as a prognostic factor for curve severity in early onset scoliosis, and later applied to other types of scoliosis as well...
May 11, 2017: Spine
https://www.readbyqxmd.com/read/28481128/traditional-growing-rod-versus-magnetically-controlled-growing-rod-for-treatment-of-early-onset-scoliosis-cost-analysis-from-implantation-till-skeletal-maturity
#17
Carlos King Ho Wong, Jason Pui Yin Cheung, Prudence Wing Hang Cheung, Cindy Lo Kuen Lam, Kenneth Man Chee Cheung
PURPOSE: To compare the yearly cost involved per patient in the use of magnetically controlled growing rod (MCGR) and traditional growing rods (TGRs) in the treatment of early onset scoliosis (EOS) and to assess the overall cost burden of MCGR with reference to patient and health-care infrastructure. METHODS: For a hypothetical case of a 5-year-old girl with a diagnosis of EOS, a decision-tree model using TreeAge Software was developed to simulate annual health state transitions and compare the 8-year accumulative direct, indirect, and total cost among the four groups: (1) dual MCGRs with exchange every 2 years, (2) dual MCGRs with exchange every 3 years, (3) TGR with surgical distraction every year, and (4) TGR with surgical distraction every 6 months...
May 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28473956/growing-spine-deformities-are-magnetic-rods-the-final-answer
#18
EDITORIAL
Ashok N Johari, Amit S Nemade
Treatment paradigms for Early Onset Scoliosis have changed from fusion to fusionless methods as the harmful effects of early fusion on the growing spine and thorax were realized. Magnetic rods are a recent addition to fusionless technology for controlling scoliosis in a growing spine. The clinical evidence base on magnet driven growth rods (MDGR) has accumulated over the last 4 years. It has implications for reduction in the number of repeat surgeries required with similar complications as the traditional growth rods (TGR) and at a higher initial cost...
April 18, 2017: World Journal of Orthopedics
https://www.readbyqxmd.com/read/28459777/analysis-of-explanted-magnetically-controlled-growing-rods-from-7-uk-spinal-centers
#19
Thomas J Joyce, Simon L Smith, Paul R P Rushton, Andrew J Bowey, Michael J Gibson
STUDY DESIGN: Analysis of explanted MAGnetic Expansion Control (MAGEC) growing rods. OBJECTIVE: To analyze explanted MAGEC rods used in management of early onset scoliosis and identify the mode of failure in such cases. SUMMARY OF BACKGROUND DATA: Magnetically controlled growing rods are increasingly used as the option of choice for early onset scoliosis. However, being more complex than conventional growing rods they are perhaps more likely to succumb to multifarious failure modes...
April 28, 2017: Spine
https://www.readbyqxmd.com/read/28456673/retrieval-and-clinical-analysis-of-distraction-based-dual-growing-rod-constructs-for-early-onset-scoliosis
#20
Genevieve Hill, Srinidhi Nagaraja, Behrooz A Akbarnia, Jeff Pawelek, Paul Sponseller, Peter Sturm, John Emans, Pablo Bonangelino, Joshua Cockrum, William Kane, Maureen Dreher
BACKGROUND CONTEXT: Growing rod constructs are an important contribution for treating patients with early-onset scoliosis. These devices experience high failure rates, including rod fractures. PURPOSE: The objective of this study was to identify the failure mechanism of retrieved growing rods, and to identify differences between patients with failed and intact constructs. STUDY DESIGN/SETTING: Growing rod patients who had implant removal and were previously enrolled in a multicenter registry were eligible for this study...
April 26, 2017: Spine Journal: Official Journal of the North American Spine Society
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