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Early-Early-Onset Scoliosis

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https://www.readbyqxmd.com/read/29782395/pull-out-of-upper-thoracic-pedicle-screws-can-cause-spinal-canal-encroachment-in-growing-rod-treatment
#1
Senol Bekmez, Aykut Kocyigit, Zeynep Deniz Olgun, Mehmet Ayvaz, Halil Gokhan Demirkiran, Ergun Karaagaoglu, Muharrem Yazici
BACKGROUND: Proximal foundation failure is a common complication of growing rod (GR) treatment for early-onset scoliosis. Spinal canal encroachment due to pull-out of pedicle screw used as proximal foundation has been anecdotally reported in GR patients. The aim of this study is to report the prevalence of spinal canal encroachment of pedicle screws in GR treatment and determine risk factors using a single-center cohort. METHODS: Inclusion criteria were: (1) GR for early-onset scoliosis and (2) pull-out of at least 1 proximal anchor pedicle screw...
May 4, 2018: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29735145/growth-friendly-surgery-is-effective-at-treating-early-onset-scoliosis-associated-with-goldenhar-syndrome
#2
Braydon Connell, Jonathan J Oore, Joshua M Pahys, George H Thompson, Tricia St Hilaire, Tara Flynn, Ron El-Hawary
OBJECTIVE: To evaluate the radiographic results and complications of growth-friendly (GF) surgery in the treatment of early-onset scoliosis (EOS) associated with Goldenhar syndrome. BACKGROUND: Goldenhar syndrome has been associated with spinal deformity, which may be progressive. Efficacy and complication rate of GF treatment has not been reported for this population of patients with EOS. METHODS: Patients with Goldenhar syndrome and EOS with two years' follow-up were identified from two international multicenter EOS databases...
May 2018: Spine Deformity
https://www.readbyqxmd.com/read/29735143/radiographic-outcome-differences-in-distraction-based-growing-rod-constructs-using-tandem-versus-wedding-band-connectors
#3
Matthew E Oetgen, Allison Matthews, Yunfei Wang, Laurel Blakemore, Jeff Pawelek, Anna McClung, Paul Sponseller, Francisco Sanchez Perez-Grueso, Behrooz Akbarnia
STUDY DESIGN: Comparative cohort study. OBJECTIVE: To compare coronal deformity control, lengthening efficacy, and sagittal alignment between distraction-based growing rod constructs utilizing tandem versus wedding band connectors. SUMMARY OF BACKGROUND DATA: Different construct designs exist for growing rod treatment of early-onset scoliosis. All use a version of a rod connector, with the two main types being tandem and wedding band. Little data exist to quantify the impact of connector choice on radiographic outcomes of treatment...
May 2018: Spine Deformity
https://www.readbyqxmd.com/read/29735142/decision-making-of-graduation-in-patients-with-early-onset-scoliosis-at-the-end-of-distraction-based-programs-risks-and-benefits-of-definitive-fusion
#4
Javier Pizones, Mar Pérez Martín-Buitrago, José Miguel Sánchez Márquez, Nicomedes Fernández-Baíllo, Montserrat Baldan-Martin, Francisco Javier Sánchez Pérez-Grueso
STUDY DESIGN: Retrospective comparative analysis. OBJECTIVE: Study early-onset scoliosis (EOS) graduated patients to establish founded criteria for graduation decision making and determine the risks and benefits of definitive fusion. SUMMARY OF BACKGROUND DATA: EOS is treated by growth-friendly techniques until skeletal maturity. Afterwards, patients can be "graduated," either by definitive fusion (posterior spinal fusion [PSF]) or by retaining the previous implants (Observation) with no additional surgery...
May 2018: Spine Deformity
https://www.readbyqxmd.com/read/29735141/expert-consensus-and-equipoise-planning-a-randomized-controlled-trial-of-magnetically-controlled-growing-rods
#5
Nicholas Feinberg, Hiroko Matsumoto, Chun Wai Hung, Tricia St Hilaire, Jeff Pawelek, Jeffrey R Sawyer, Behrooz A Akbarnia, David L Skaggs, Benjamin D Roye, David P Roye, Michael G Vitale
STUDY DESIGN: Expert consensus building using combined Delphi method and Nominal group technique. OBJECTIVES: To identify the current state of equipoise surrounding the use of magnetically controlled growing rods (MCGRs) and to determine consensus for planning a randomized controlled trial (RCT) with MCGRs. BACKGROUND: The use of MCGRs for the treatment of early-onset scoliosis (EOS) is a new technology. Optimal use has not been thoroughly investigated and much uncertainty exists...
May 2018: Spine Deformity
https://www.readbyqxmd.com/read/29735139/cadaveric-study-of-the-safety-and-device-functionality-of-magnetically-controlled-growing-rods-after-exposure-to-magnetic-resonance-imaging
#6
Selina Poon, Yen Hsun Chen, Stephen F Wendolowski, Adam Graver, Ryan Nixon, Terry Amaral, Jon-Paul DiMauro, Daniel M Walz, Rachel C Gecelter, Daniel A Grande
STUDY DESIGN: Cadaveric study. OBJECTIVE: To establish the safety and efficacy of magnetically controlled growing rods (MCGRs) after magnetic resonance imaging (MRI) exposure. SUMMARY OF BACKGROUND DATA: MCGRs are new and promising devices for the treatment of early-onset scoliosis (EOS). A significant percentage of EOS patients have concurrent spinal abnormalities that need to be monitored with MRI. There are major concerns of the MRI compatibility of MCGRs because of the reliance of the lengthening mechanism on strongly ferromagnetic actuators...
May 2018: Spine Deformity
https://www.readbyqxmd.com/read/29735135/diagnosis-of-spondylolysis-and-spondylolisthesis-is-delayed-six-months-after-seeing-nonorthopedic-providers
#7
Ena Nielsen, Lindsay M Andras, David L Skaggs
STUDY DESIGN: Retrospective single center. OBJECTIVE: Our purpose was to quantify the time to diagnosis of spondylolysis/spondylolisthesis in symptomatic patients after first seeking medical care. SUMMARY OF BACKGROUND DATA: Several studies have found a high prevalence of pars defects in adolescent athletes with back pain, up to 47%. A review by the Scoliosis Research Society Evidence-Based Medicine Committee reports that both nonsurgical and surgical treatment of symptomatic spondylolysis effectively relieves pain and allows most patients to return to activities...
May 2018: Spine Deformity
https://www.readbyqxmd.com/read/29727414/comprehensive-assessment-of-outcomes-from-patients-with-severe-early-onset-scoliosis-treated-with-a-vertebral-column-resection-results-from-an-srs-global-outreach-site-focos-in-ghana
#8
Kushagra Verma, Casey Slattery, Henry Duah, Kawdwo P Yankey, Gregory Mundis, Oheneba Boachie-Adjel
BACKGROUND: Early-onset scoliosis (EOS) remains a challenging pediatric spine condition to manage. Some severe deformities can be managed with a vertebral column resection (VCR), which is fraught with high complication rates and the outcomes have not been well reported. The purpose of this study is to provide an assessment of operative, radiographic, and clinical outcomes from children diagnosed with severe EOS treated with a VCR. METHODS: We performed a retrospective review of prospectively collected data...
April 30, 2018: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29705176/natural-history-of-scoliosis-in-cerebral-palsy-and-risk-factors-for-progression-of-scoliosis
#9
Kiyoshi Yoshida, Ichiro Kajiura, Tsunehiko Suzuki, Hidehiko Kawabata
BACKGROUND: Scoliosis in cerebral palsy (CP) often occurs and causes a disturbance in daily life. The purpose of this study was to investigate the natural history of scoliosis in cerebral palsy and determine risk factors for the progression of scoliosis using multivariate analyses. METHODS: We revised 113 patients with CP (47 males and 66 females) who had scoliosis with a curve of at least 10° were reviewed and retrospectively investigated these cases of scoliosis and analyzed the risk factors for the progression of this condition...
April 25, 2018: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/29691892/congenital-titinopathy-comprehensive-characterisation-and-pathogenic-insights
#10
Emily C Oates, Kristi J Jones, Sandra Donkervoort, Amanda Charlton, Susan Brammah, John E Smith, James S Ware, Kyle S Yau, Lindsay C Swanson, Nicola Whiffin, Anthony J Peduto, Adam Bournazos, Leigh B Waddell, Michelle A Farrar, Hugo A Sampaio, Hooi Ling Teoh, Phillipa J Lamont, David Mowat, Robin B Fitzsimons, Alastair J Corbett, Monique M Ryan, Gina L O'Grady, Sarah A Sandaradura, Roula Ghaoui, Himanshu B Joshi, Jamie L Marshall, Melinda A Nolan, Simranpreet Kaur, Jaya Punetha, Ana Töpf, Elizabeth Harris, Madhura Bakshi, Casie A Genetti, Minttu Marttila, Ulla Werlauff, Nathalie Streichenberger, Alan Pestronk, Ingrid Mazanti, Jason R Pinner, Carole Vuillerot, Carla Grosmann, Ana Camacho, Payam Mohassel, Meganne E Leach, A Reghan Foley, Diana Bharucha-Goebel, James Collins, Anne M Connolly, Heather R Gilbreath, Susan T Iannaccone, Diana Castro, Beryl B Cummings, Richard I Webster, Leïla Lazaro, John Vissing, Sandra Coppens, Nicolas Deconinck, Ho-Ming Luk, Neil H Thomas, Nicola C Foulds, Marjorie A Illingworth, Sian Ellard, Catriona A McLean, Rahul Phadke, Gianina Ravenscroft, Nanna Witting, Peter Hackman, Isabelle Richard, Sandra T Cooper, Erik-Jan Kamsteeg, Eric P Hoffman, Kate Bushby, Volker Straub, Bjarne Udd, Ana Ferreiro, Kathryn N North, Nigel F Clarke, Monkol Lek, Alan H Beggs, Carsten G Bönnemann, Daniel G MacArthur, Henk Granzier, Mark R Davis, Nigel G Laing
OBJECTIVE: Comprehensive clinical characterisation of congenital titinopathy to facilitate diagnosis and management of this important emerging disorder. METHODS: Using massively parallel sequencing we identified 30 patients from 27 families with two pathogenic nonsense, frameshift and/or splice site TTN mutations in trans. We then undertook a detailed analysis of the clinical, histopathology and imaging features of these patients. RESULTS: All patients had prenatal- or early-onset hypotonia and/or congenital contractures...
April 25, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29675673/systematic-review-of-the-complications-associated-with-magnetically-controlled-growing-rods-for-the-treatment-of-early-onset-scoliosis
#11
REVIEW
Chrishan Thakar, David Christopher Kieser, Mihai Mardare, Shahnawaz Haleem, Jeremy Fairbank, Colin Nnadi
PURPOSE: To analyse the complication profile of magnetically controlled growing rods (MCGRs) in early onset scoliosis (EOS). METHODS: This is a systematic review using PUBMED, Medline, Embase, Google Scholar and the Cochrane Library (keywords: MAGEC, Magnetically controlled growing rods and EOS) of all studies written in English with a minimum of five patients and a 1-year follow-up. We evaluated coronal correction, growth progression (T1-S1, T1-T12) and complications...
April 19, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29664812/health-related-quality-of-life-and-body-image-disturbance-of-adolescents-with-severe-untreated-idiopathic-early-onset-scoliosis-in-a-developing-country
#12
Hany Abdel Gawwad Soliman
STUDY DESIGN: A cross sectional study OBJECTIVE.: This study aimed to investigate the health-related quality of life (HRQOL) and body image disturbance of adolescents with untreated severe idiopathic early-onset scoliosis (IEOS) in a developing country. SUMMARY OF BACKGROUND DATA: IEOS has the potential to progress rapidly and may lead to significant disability if left untreated. Moreover, it can lead to significant body image changes that may lead to social and psychological stresses on developing adolescents...
April 16, 2018: Spine
https://www.readbyqxmd.com/read/29657440/magnetic-growth-modulation-in-orthopaedic-and-spine-surgery
#13
REVIEW
Adam E M Eltorai, Carolina Fuentes
Purpose: To examine distraction-based methods for treatment of early onset scoliosis (EOS), focusing on the magnetically controlled growing rod system (MCGR) relative to traditional growing rod system (TGR). To briefly discuss internal magnetically controlled nails for bone lengthening as another application of magnetic growth modulation. Results: Relative to TGR, MCGR involves fewer complications related to infection and general anesthesia because of fewer successive surgeries required...
March 2018: Journal of Orthopaedics
https://www.readbyqxmd.com/read/29649090/reliability-of-rod-lengthening-thoracic-and-spino-pelvic-measurements-on-biplanar-stereoradiography-in-patients-treated-with-magnetically-controlled-growing-rods
#14
Peter Obid, Karen Kar Lum Yiu, Kenneth Mc Cheung, Kenny Kwan, Michael Ruf, Jason Pui Yin Cheung
STUDY DESIGN: Cross-sectional study. OBJECTIVE: To assess the inter- and intraobserver reliability of thoracic, spino-pelvic and rod lengthening measurements made on biplanar spinal stereoradiography (EOS imaging) in children treated with magnetically controlled growing rod (MCGR). SUMMARY OF BACKGROUND DATA: MCGR treatment aims to gain spine length while gradually correcting the spinal deformity. Monitoring thoracic and spino-pelvic parameters are crucial for successful management...
April 11, 2018: Spine
https://www.readbyqxmd.com/read/29649083/targeted-distraction-spinal-growth-in-children-with-early-onset-scoliosis-treated-with-a-tail-gating-technique-for-magnetically-controlled-growing-rods
#15
Mihai Mardare, David Christopher Kieser, Adil Ahmad, Thejasvi Subramanian, Shahnawaz Haleem, Chrishan Thakar, James Wilson-MacDonald, Colin Nnadi
STUDY DESIGN: Prospective cohort study OBJECTIVE.: To understand the efficacy of a tail-gating technique (TGT) to mirror the normal spinal growth of children with early-onset scoliosis (EOS) treated with magnetically controlled growing rods (MCGR). SUMMARY OF BACKGROUND DATA: MCGR allow outpatient distraction and guided spinal growth without the need for repeat surgery. Two techniques (maximal and targeted) are currently employed to determine the distraction amount, however the efficacy of each is unknown...
April 11, 2018: Spine
https://www.readbyqxmd.com/read/29644031/the-use-of-magnetically-controlled-growing-rods-in-paediatric-osteogenesis-imperfecta-with-early-onset-progressive-scoliosis
#16
A Gardner, J Sahota, H Dong, V Saraff, W Högler, N J Shaw
Osteogenesis Imperfecta (OI) is a condition of bone fragility and can present with early onset scoliosis that can cause respiratory complications in later life. The fear of instrumenting the spine in OI is the possibility of fracture either on primary insertion or subsequent lengthening. Magnetically controlled growing rods were inserted to control a scoliosis in a 6-year old with OI type IV. Fixation was obtained using pedicle screws proximally and distally with sublaminar bands around the ribs proximally...
March 2018: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29629587/an-nihr-approved-two-year-observational-study-on-magnetically-controlled-growth-rods-in-the-treatment-of-early-onset-scoliosis
#17
C Nnadi, C Thakar, J Wilson-MacDonald, P Milner, A Rao, D Mayers, J Fairbank, T Subramanian
Aims The primary aim of this study was to evaluate the performance and safety of magnetically controlled growth rods in the treatment of early onset scoliosis. Secondary aims were to evaluate the clinical outcome, the rate of further surgery, the rate of complications, and the durability of correction. Patients and Methods We undertook an observational prospective cohort study of children with early onset scoliosis, who were recruited over a one-year period and followed up for a minimum of two years. Magnetically controlled rods were introduced in a standardized manner with distractions performed three-monthly thereafter...
April 1, 2018: Bone & Joint Journal
https://www.readbyqxmd.com/read/29618507/further-delineation-of-the-mecp2-duplication-syndrome-phenotype-in-59-french-male-patients-with-a-particular-focus-on-morphological-and-neurological-features
#18
Marguerite Miguet, Laurence Faivre, Jeanne Amiel, Mathilde Nizon, Renaud Touraine, Fabienne Prieur, Laurent Pasquier, Mathilde Lefebvre, Julien Thevenon, Christèle Dubourg, Sophie Julia, Catherine Sarret, Ganaëlle Remerand, Christine Francannet, Fanny Laffargue, Odile Boespflug-Tanguy, Albert David, Bertrand Isidor, Jacqueline Vigneron, Bruno Leheup, Laetitia Lambert, Christophe Philippe, Mylène Béri-Dexheimer, Jean-Marie Cuisset, Joris Andrieux, Ghislaine Plessis, Annick Toutain, Laurent Guibaud, Valérie Cormier-Daire, Marlene Rio, Jean-Paul Bonnefont, Bernard Echenne, Hubert Journel, Lydie Burglen, Sandrine Chantot-Bastaraud, Thierry Bienvenu, Clarisse Baumann, Laurence Perrin, Séverine Drunat, Pierre-Simon Jouk, Klaus Dieterich, Françoise Devillard, Didier Lacombe, Nicole Philip, Sabine Sigaudy, Anne Moncla, Chantal Missirian, Catherine Badens, Nathalie Perreton, Christel Thauvin-Robinet, Réseau AChro-Puce, Jean-Michel Pedespan, Caroline Rooryck, Cyril Goizet, Catherine Vincent-Delorme, Bénédicte Duban-Bedu, Nadia Bahi-Buisson, Alexandra Afenjar, Kim Maincent, Delphine Héron, Jean-Luc Alessandri, Dominique Martin-Coignard, Gaëtan Lesca, Massimiliano Rossi, Martine Raynaud, Patrick Callier, Anne-Laure Mosca-Boidron, Nathalie Marle, Charles Coutton, Véronique Satre, Cédric Le Caignec, Valérie Malan, Serge Romana, Boris Keren, Anne-Claude Tabet, Valérie Kremer, Sophie Scheidecker, Adeline Vigouroux, Marilyn Lackmy-Port-Lis, Damien Sanlaville, Marianne Till, Maryline Carneiro, Brigitte Gilbert-Dussardier, Marjolaine Willems, Hilde Van Esch, Vincent Des Portes, Salima El Chehadeh
The Xq28 duplication involving the MECP2 gene ( MECP2 duplication) has been mainly described in male patients with severe developmental delay (DD) associated with spasticity, stereotypic movements and recurrent infections. Nevertheless, only a few series have been published. We aimed to better describe the phenotype of this condition, with a focus on morphological and neurological features. Through a national collaborative study, we report a large French series of 59 affected males with interstitial MECP2 duplication...
April 4, 2018: Journal of Medical Genetics
https://www.readbyqxmd.com/read/29588607/cost-analysis-of-a-growth-guidance-system-compared-with-traditional-and-magnetically-controlled-growing-rods-for-early-onset-scoliosis-a-us-based-integrated-health-care-delivery-system-perspective
#19
Scott J Luhmann, Eoin M McAughey, Stacey J Ackerman, David B Bumpass, Richard E McCarthy
Purpose: Treating early-onset scoliosis (EOS) with traditional growing rods (TGR) is effective but requires periodic surgical lengthening, risking complications. Alternatives include magnetically controlled growing rods (MCGR) that lengthen noninvasively and the growth guidance system (GGS), which obviate the need for active, distractive lengthenings. Previous studies have reported promising clinical effectiveness for GGS; however the direct medical costs of GGS compared to TGR and MCGR have not yet been explored...
2018: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/29580223/association-between-braced-curve-behavior-by-pubertal-growth-peak-and-bracing-effectiveness-in-female-idiopathic-scoliosis-a-longitudinal-cohort-study
#20
Sai-Hu Mao, Xu Sun, Ben-Long Shi, Yong Qiu, Bang-Ping Qian, Jack C Y Cheng
BACKGROUND: Pre-pubertal idiopathic scoliosis (IS) is associated with high risk of bracing ineffectiveness. Integrated multidimensional maturity assessments are useful but complex to predict the high-risk occurrence of curve progression. This study is designed to provide a simple screening method for brace effectiveness by determining whether or not the braced curve behavior at growth spurt, being defined as variations in Cobb angle velocity (AV) at peak height velocity (PHV), can be a new factor predictive of brace outcome prescribed before PHV...
March 27, 2018: BMC Musculoskeletal Disorders
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