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Early-Early-Onset Scoliosis

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https://www.readbyqxmd.com/read/28174478/scoliosis-in-adulthood-a-case-with-untreated-early-onset-scoliosis-presenting-at-the-age-of-76-years
#1
Hans-Rudolf Weiss
[Purpose] Untreated early-onset scoliosis may eventually progress to more than 90° after growth, cause severe health problems, and increase chance of mortality. Therefore, surgical intervention is often indicated prior to the development of a life-threatening deformity. This case report aims to reveal how a 76-year-old male patient with curves exceeding 110° is functioning with minimal difficulty. [Subject and Methods] The patient, who has never had surgical intervention for scoliosis, can perform his everyday activities...
December 2016: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28173581/book-review-early-onset-scoliosis-a-comprehensive-guide-from-the-oxford-meetings
#2
Peter F Sturm
No abstract text is available yet for this article.
February 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28141685/veptr-implantation-to-treat-children-with-early-onset-scoliosis-without-rib-abnormalities-early-results-from-a-prospective-multicenter-study
#3
Ron El-Hawary, Muayad Kadhim, Michael Vitale, John Smith, Amer Samdani, John M Flynn
BACKGROUND: Thoracoplasty and insertion of vertical expandable prosthetic titanium rib (VEPTR) for thoracic and spine distraction has been found to be effective in the treatment of early-onset scoliosis (EOS) with ribs anomalies and congenital vertebral anomalies. The aim of this study was to evaluate the efficacy of VEPTR in preventing further progression of scoliosis without impeding spinal growth in children with progressive EOS without rib abnormalities. METHODS: This is a prospective, multicenter, observational cohort study...
January 30, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28102447/analysing-a-mechanism-of-failure-in-retrieved-magnetically-controlled-spinal-rods
#4
Vasiliki C Panagiotopoulou, Stewart K Tucker, Robert K Whittaker, Harry S Hothi, Johann Henckel, Julian J H Leong, Thomas Ember, John A Skinner, Alister J Hart
PURPOSE: We aim to describe a mechanism of failure in magnetically controlled growth rods which are used for the correction of the early onset scoliosis. METHODS: This retrieval study involved nine magnetically controlled growth rods, of a single design, revised from five patients for metal staining, progression of scoliosis, swelling, fractured actuator pin, and final fusion. All the retrieved rods were radiographed and assessed macroscopically and microscopically for material loss...
January 19, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28079273/abnormal-fetal-muscle-forces-result-in-defects-in-spinal-curvature-and-alterations-in-vertebral-segmentation-and-shape
#5
Rebecca A Rolfe, James H Bezer, Tyler Kim, Ahmed Z Zaidon, Michelle L Oyen, James C Iatridis, Niamh C Nowlan
The incidence of congenital spine deformities, including congenital scoliosis, kyphosis and lordosis, may be influenced by the in utero mechanical environment, and particularly by fetal movements at critical time-points. There is a limited understanding of the influence of fetal movements on spinal development, despite the fact that mechanical forces have been shown to play an essential role in skeletal development of the limb. This study investigates the effects of muscle forces on spinal curvature, vertebral segmentation and vertebral shape by inducing rigid or flaccid paralysis in the embryonic chick...
January 12, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28054739/compound-heterozygosity-for-null-mutations-and-a-common-hypomorphic-risk-haplotype-in-tbx6-causes-congenital-scoliosis
#6
Kazuki Takeda, Ikuyo Kou, Noriaki Kawakami, Aritoshi Iida, Masahiro Nakajima, Yoji Ogura, Eri Imagawa, Noriko Miyake, Naomichi Matsumoto, Yukuto Yasuhiko, Hideki Sudo, Toshiaki Kotani, Masaya Nakamura, Morio Matsumoto, Kota Watanabe, Shiro Ikegawa
Congenital scoliosis (CS) occurs as a result of vertebral malformations and has an incidence of 0.5-1/1,000 births. Recently, TBX6 on chromosome 16p11.2 was reported as a disease gene for CS; about 10% of Chinese CS patients were compound heterozygotes for rare null mutations and a common haplotype defined by three SNPs in TBX6. All patients had hemivertebrae. We recruited 94 Japanese CS patients, investigated the TBX6 locus for both mutations and the risk haplotype, examined transcriptional activities of mutant TBX6 in vitro, and evaluated clinical and radiographic features...
March 2017: Human Mutation
https://www.readbyqxmd.com/read/28044467/magnetically-controlled-growing-rods-for-scoliosis-surgery
#7
Umesh Metkar, Swamy Kurra, David Quinzi, Stephen Albanese, William F Lavelle
Early onset scoliosis can be both a disfiguring as well as a life threatening condition. When more conservative treatments fail, pediatric spinal surgeons are forced to consider operative interventions. Traditionally, these interventions have involved the insertion of a variety of implants into the patient with a limited number of anchor points controlling the spine. In the past, these pediatric patients have had multiple surgeries for elective lengthening of these devices to facilitate their growth while attempting to control the scoliosis...
January 3, 2017: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/28040873/magnetically-controlled-growing-rod-in-early-onset-scoliosis-a-30-case-multicenter-study
#8
REVIEW
Julie Lebon, Cécile Batailler, Matthieu Wargny, Elie Choufani, Philippe Violas, Damien Fron, Jerry Kieffer, Franck Accadbled, Vincent Cunin, Jérôme Sales De Gauzy
PURPOSE: Preliminary results of magnetically controlled growing rods (MCGR) are encouraging. However, only short case series of MCGR for the treatment of early onset scoliosis (EOS) have been reported. Our aim was to evaluate its effectiveness and complications. METHODS: We report a 30-case retrospective, consecutive, multicenter series of MCGR. Effectiveness was judged upon: deformity correction and difficulties to achieve desired distraction. Secondary endpoints included complications and revision surgeries...
December 31, 2016: European Spine Journal
https://www.readbyqxmd.com/read/28038690/the-development-of-a-representative-porcine-early-onset-scoliosis-model-with-a-standalone-posterior-spinal-tether
#9
R Bogie, A K Roth, P C Willems, Vd W Weegen, J J Arts, L W van Rhijn
STUDY DESIGN: In vivo analysis in a porcine model. OBJECTIVES: To develop a porcine experimental scoliosis model representative of early-onset scoliosis (EOS) with the use of a radiopaque ultra-high molecular weight polyethylene (UHMWPE) posterior spinal tether. SUMMARY OF BACKGROUND DATA: Large animal experimental scoliosis models with substantial growth potential are needed to test new fusionless scoliosis correction techniques. Previously described scoliosis models involve rib procedures, which violate the thoracic cage and affect subsequent corrective procedures...
January 2017: Spine Deformity
https://www.readbyqxmd.com/read/28031501/frequent-small-distractions-with-a-magnetically-controlled-growing-rod-for-early-onset-scoliosis-and-avoidance-of-the-law-of-diminishing-returns
#10
Jason Pui Yin Cheung, Cora Bow, Dino Samartzis, Kenny Kwan, Kenneth Man Chee Cheung
PURPOSE: To assess the effect of frequent small distractions with a magnetically controlled growing rod (MCGR) on spinal length gain and achieved distraction length in children with early-onset scoliosis (EOS), and to determine whether the law of diminishing returns applies to this group of patients with MCGR. METHODS: A consecutive series of 3 males and 4 females with EOS who underwent MCGR implantation at a mean age of 10.2 years and were followed up for a mean of 3...
December 2016: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/27994795/long-term-effects-of-untreated-adolescent-idiopathic-scoliosis-a-review-of-the-literature
#11
REVIEW
Hans-Rudolf Weiss, Nikos Karavidas, Marc Moramarco, Kathryn Moramarco
Currently, adolescent idiopathic scoliosis (AIS) is principally regarded as benign, but some researchers have cited serious or extreme effects, including severe pain, cardiopulmonary compromise, social isolation, and even early death. Therefore, exploration of the long-term effects of AIS, the most common type of idiopathic scoliosis, is warranted. The purpose of this review was to examine the long-term studies on the natural history of AIS and/or reviews concerning the long-term effects of untreated AIS. A PubMed search was conducted using the key words idiopathic scoliosis, long-term effects and idiopathic scoliosis, natural history...
December 2016: Asian Spine Journal
https://www.readbyqxmd.com/read/27942940/growth-modulation-and-remodeling-by-means-of-posterior-tethering-technique-for-correction-of-early-onset-scoliosis-with-thoracolumbar-kyphosis
#12
Alaaeldin A Ahmad, Loai Aker, Yahia Hanbali, Aesha Sbaih, Zaher Nazzal
PURPOSE: The aim of this study is to evaluate the role of the non-fusion instrumented procedure with compression adjunct to lengthening by distraction in facilitating spinal modulation of the wedged peak vertebra, in patients with congenital thoracolumbar kyphosis/kyphoscoliosis according to the Hueter-Volkmann law. The authors seek to address the progressive modulation of the most wedged vertebra by analyzing the subjects' pre-operative and latest follow-up sagittal radiograph. METHODS: Ongoing data collection of 14 peak wedged vertebra modulation during surgical management of 13 patients with Type I congenital thoracolumbar kyphosis (5 patients) or kyphoscoliosis (8 patients)...
December 9, 2016: European Spine Journal
https://www.readbyqxmd.com/read/27942472/cutis-tricolor-a-literature-review-and-report-of-five-new-cases
#13
Martino Ruggieri, Agata Polizzi, Carmelo Schepis, Massimiliano Morano, Serena Strano, Giuseppe Belfiore, Stefano Palmucci, Pietro Valerio Foti, Concetta Pirrone, Mario Roggini, Emanule David, Vincenzo Salpietro, Pietro Milone
BACKGROUND: Cutis tricolor is a skin abnormality consisting in a combination of congenital hyper- and hypopigmented skin lesions (in the form of paired macules, patches or streaks) in close proximity to each other in a background of normal skin. It is currently regarded as a twin-spotting (mosaic) phenomenon and today is clear that not all cases of cutis tricolor represent one single entity. This phenomenon has been reported so far either: (I) as an purely cutaneous trait; (II) as a part of a complex malformation phenotype (Ruggieri-Happle syndrome, RHS) including distinct facial features, eye (cataract), skeletal (skull and vertebral defects, and long bones dysplasia), nervous system (corpus callosum, cerebellar and white matter anomalies, cavum vergae and holoprosencephaly) and systemic abnormalities; (III) as a distinct type with multiple, disseminated smaller skin macules (cutis tricolor parvimaculata); and (IV) in association with other skin disturbances [e...
October 2016: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/27939256/do-growing-rods-for-idiopathic-early-onset-scoliosis-improve-activity-and-participation-for-children
#14
Mathew David Sewell, Johnson Platinum, Geoffrey Noel Askin, Robert Labrom, Mike Hutton, Daniel Chan, Andrew Clarke, Oliver M Stokes, Sean Molloy, Stewart Tucker, Jan Lehovsky
OBJECTIVE: To investigate whether growing rod surgery for children with progressive idiopathic early onset scoliosis (EOS) effects activity and participation, and investigate factors that may affect this. STUDY DESIGN: Multicenter retrospective cohort study using prospectively collected data on 60 children with idiopathic EOS and significant scoliosis (defined as a Cobb angle >40°). Thirty underwent brace treatment, and 30, growth rod surgery. Questionnaire and radiographic data were recorded at 1 year...
December 6, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27927570/exercise-tolerance-in-children-with-early-onset-scoliosis-growing-rod-treatment-graduates
#15
Kelly A Jeans, Charles E Johnston, Wilshaw R Stevens, Dong-Phuong Tran
STUDY DESIGN: Prospectively enrolled early-onset scoliosis (EOS) patients undergoing growing rod treatment, who have had no surgery for >1 year and/or have received definitive fusion (growing rod "graduates"). OBJECTIVES: To assess oxygen consumption during exercise and determine if a diminished conventional pulmonary function test (PFT) correlates with metabolic, pulmonary, and cardiovascular measures during exercise. SUMMARY OF BACKGROUND DATA: Based on clinical impression and sequential PFT values, EOS patients who have undergone extensive treatment are thought to have limited capacity during exercise...
November 2016: Spine Deformity
https://www.readbyqxmd.com/read/27927569/complications-and-radiographic-outcomes-of-posterior-spinal-fusion-and-observation-in-patients-who-have-undergone-distraction-based-treatment-for-early-onset-scoliosis
#16
Jeffrey R Sawyer, Rodrigo Góes Medéa de Mendonça, Tara S Flynn, Amer F Samdani, Ron El-Hawary, Alan J Spurway, John T Smith, John B Emans, Tricia A St Hilaire, Stephen J Soufleris, Ryan P Murphy
STUDY DESIGN: Retrospective, multicenter. OBJECTIVES: To compare surgical and radiographic outcomes of early-onset scoliosis (EOS) patients who had stopped lengthening for ≥2 years without additional surgery to those who had posterior spinal fusion (PSF) at the end of lengthening. SUMMARY OF BACKGROUND DATA: Because of the risk of significant complications with PSF in patients with EOS, "watchful waiting" at the end of lengthening has been suggested as a viable alternative...
November 2016: Spine Deformity
https://www.readbyqxmd.com/read/27927505/outcomes-of-pelvic-fixation-in-growing-rod-constructs-an-analysis-of-patients-with-a-minimum-of-4-years-of-follow-up
#17
Jaysson T Brooks, Amit Jain, Francisco Sanchez-Perez-Grueso, David L Skaggs, George H Thompson, Behrooz A Akbarnia, Paul D Sponseller
STUDY DESIGN: Retrospective review. OBJECTIVE: To evaluate which distal anchors in growing rod (GR) constructs optimally correct major curve, pelvic obliquity, sagittal alignment, T1-S1 length, thoracic kyphosis, and lumbar lordosis with the fewest complications at 4 or more years' postoperative follow-up. SUMMARY OF BACKGROUND DATA: Pelvic fixation to the ilium and/or sacrum in GR constructs is used to treat patients with early-onset scoliosis...
May 2016: Spine Deformity
https://www.readbyqxmd.com/read/27927491/age-at-initiation-and-deformity-magnitude-influence-complication-rates-of-surgical-treatment-with-traditional-growing-rods-in-early-onset-scoliosis
#18
Vidyadhar V Upasani, Kevin C Parvaresh, Jeff B Pawelek, Patricia E Miller, George H Thompson, David L Skaggs, John B Emans, Michael P Glotzbecker
STUDY DESIGN: Multi-center retrospective review. OBJECTIVE: The purpose of this study was to identify preoperative variables associated with postoperative complications in early-onset scoliosis (EOS) patients treated with traditional growing rods (TGR); and to develop a model to predict the incidence of postoperative complications based on preoperative variables. SUMMARY OF BACKGROUND DATA: TGRs are commonly used to treat progressive EOS. Prior research has demonstrated a high rate of postoperative complications using this technique; however, few studies have identified preoperative factors that contribute to such complications...
September 2016: Spine Deformity
https://www.readbyqxmd.com/read/27927489/sagittal-spine-length-measurement-a-novel-technique-to-assess-growth-of-the-spine
#19
Alan J Spurway, Chukwudi K Chukwunyerenwa, Waleed E Kishta, Jennifer K Hurry, Ron El-Hawary
STUDY DESIGN: The accuracy and repeatability of a novel sagittal spine length (SSL) radiographic measurement was examined using photographic and radiographic imaging. OBJECTIVES: To validate the new SSL technique for measuring growth in early-onset scoliosis (EOS) patients. SUMMARY OF BACKGROUND DATA: Current assessment of patient growth undergoing growth-friendly surgical treatment for EOS is the use of serial vertical spine height measurements (VH) on coronal radiographs...
September 2016: Spine Deformity
https://www.readbyqxmd.com/read/27909129/metallosis-following-implantation-of-magnetically-controlled-growing-rods-in-the-treatment-of-scoliosis-a-case-series
#20
K H Teoh, C von Ruhland, S L Evans, S H James, A Jones, J Howes, P R Davies, S Ahuja
AIMS: We present a case series of five patients who had revision surgery following magnetic controlled growing rods (MGCR) for early onset scoliosis. Metallosis was found during revision in four out of five patients and we postulated a mechanism for rod failure based on retrieval analysis. PATIENTS AND METHODS: Retrieval analysis was performed on the seven explanted rods. The mean duration of MCGR from implantation to revision was 35 months (17 to 46). The mean age at revision was 12 years (7 to 15; four boys, one girl)...
December 2016: Bone & Joint Journal
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