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https://www.readbyqxmd.com/read/29135529/acute-coronary-artery-thrombus-after-tranexamic-acid-during-total-shoulder-arthroplasty-in-a-patient-with-coronary-stents-a-case-report
#1
Kathryn H Bridges, Sylvia H Wilson
Tranexamic Acid (TXA), an antifibrinolytic, is routinely used to decrease transfusion rates in total joint replacement surgery. While recent publications have indicated a low risk of TXA-associated thromboembolic events in this orthopedic population, few studies specifically address the safety of TXA administration in high-risk patients. We present a case of acute coronary thrombus requiring emergent intervention in a patient with indwelling coronary stents who underwent shoulder arthroplasty with TXA administration...
November 9, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/29125679/topical-tranexamic-acid-compared-with-anterior-nasal-packing-for-treatment-of-epistaxis-in-patients-taking-antiplatelet-drugs-randomized-controlled-trial
#2
Reza Zahed, Mohammad Hossain Mousavi Jazayeri, Asieh Naderi, Zeinab Naderpour, Morteza Saeedi
OBJECTIVE: We evaluated the efficacy of topical application of the injectable form of tranexamic acid (TXA) compared with anterior nasal packing (ANP) for the treatment of epistaxis in patients taking antiplatelet drugs (Aspirin, Clopidegrol or both) who presented to the emergency department (ED). METHODS: A randomized, parallel group clinical trial was conducted at 2 EDs. A total of 124 participants were randomized to receive topical TXA (500 mg in 5 ml) or ANP, 62 patients per group...
November 10, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29120963/high-dose-versus-low-dose-tranexamic-acid-to-reduce-transfusion-requirements-in-pediatric-scoliosis-surgery
#3
Daniel J Johnson, Christine C Johnson, Susan M Goobie, Nina Nami, Joshua A Wetzler, Paul D Sponseller, Steven M Frank
BACKGROUND: Our objective was to quantify blood loss and transfusion requirements for high-dose and low-dose tranexamic acid (TXA) dosing regimens in pediatric patients undergoing spinal fusion for correction of idiopathic scoliosis. Previous investigators have established the efficacy of TXA in pediatric scoliosis surgery; however, the dosing regimens vary widely and the optimal dose has not been established. METHODS: We retrospectively analyzed electronic medical records for 116 patients who underwent spinal fusion surgery for idiopathic scoliosis by a single surgeon and were treated with TXA...
December 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29119286/no-effect-of-topical-application-of-tranexamic-acid-on-articular-cartilage
#4
Luiz Felipe Ambra, Laura de Girolamo, Wanting Niu, Amy Phan, Myron Spector, Andreas H Gomoll
PURPOSE: The objective of this study was to evaluate potential cytotoxicity of TXA on articular cartilage by assessing chondrocyte viability of osteochondral explants after exposure to different concentrations and durations of TXA. METHODS: Thirty-nine osteochondral plugs (OCPs) were harvested from three adult Yucatan minipigs immediately after their death. OCPs were divided into 13 groups exposed to different concentrations of TXA (1, 2 and 4 mg/ml in saline solution) for 1, 3 and 6 h...
November 8, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29119064/administration-of-tranexamic-acid-in-trauma-patients-under-stricter-inclusion-criteria-increases-the-treatment-window-for-stabilization-from-24-to-48-hours-a-retrospective-review
#5
Eric Luehr, Gary Grone, Manoj Pathak, Cindy Austin, Simon Thompson
BACKGROUND: Since 2010, the use of Tranexamic Acid (TXA) in trauma has been brought to the forefront of severe hemorrhage treatment. However, the mixed literature illustrates the need for additional proof of efficacy and determining which patients may benefit from TXA. The purpose of this retrospective study was to evaluate a more stringent TXA inclusion criterion (heart rate ≥ 120 beats per minute (BPM) with a systolic blood pressure (SBP) ≤ 90 mmHg) as compared to the standard CRASH-2 inclusion criteria...
2017: International Journal of Burns and Trauma
https://www.readbyqxmd.com/read/29114428/does-intravenous-tranexamic-acid-reduce-blood-loss-during-surgically-assisted-rapid-palatal-expansion
#6
Emine Akbas, Zerrin Cebi, Erol Cansiz, Sabri Cemil Isler, Sırmahan Cakarer
Purpose: The purpose of this study was to evaluate the efficacy of tranexamic acid (TXA) in reducing blood loss during surgically assisted rapid palatal expansion (SARPE) procedure. Subjects and Methods: A total of 34 patients (12 male, 22 female) who had been treated surgically under general anesthesia with SARPE including pterygoid disjunction for transverse maxillary deficiency (TMD) were included in this study. The study group (n=17) received intravenous (IV) TXA 10 mg/kg as a preoperative bolus; the control group (n=17) received normal saline solution...
2017: J Istanb Univ Fac Dent
https://www.readbyqxmd.com/read/29110696/a-randomized-controlled-trial-on-the-effects-of-collagen-sponge-and-topical-tranexamic-acid-in-posterior-spinal-fusion-surgeries
#7
Derong Xu, Qianyu Zhuang, Zheng Li, Zhinan Ren, Xin Chen, Shugang Li
BACKGROUND: This is a randomized controlled trial research to assess the hemostatic efficacy of gelatin sponge, collagen sponge, and topical use of tranexamic acid (TXA) on postoperative blood loss in posterior spinal fusion surgeries. METHODS: We recruited patients with spinal degenerative diseases into the study from November 2013 to October 2016. All the participants were assigned to 3 groups using a simple, equal-probability randomization scheme: group A is a control group utilizing gelatin sponge, while groups B and C are experimental groups, applying collagen hemostatic sponge and topical TXA respectively...
November 6, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29108091/effects-of-low-dose-epinephrine-on-perioperative-hemostasis-and-inflammatory-reaction-in-major-surgeries-a%C3%A2-randomized%C3%A2-clinical-trial
#8
J L Liu, W N Zeng, F Y Wang, C Chen, X Y Gong, H Yang, Z J Tan, X L Jia, L Yang
BACKGROUND: Haemostasis, thrombosis, and surgical stress-induced immune reaction are important for perioperative morbidity and recovery in major surgeries. OBJECTIVES: This study aimed to evaluate the effects of combined administration of low-dose epinephrine (LDEPI) plus tranexamic acid (TXA) on perioperative blood loss, thromboembolic complications, and inflammatory response in total hip arthroplasty (THA). PATIENTS /METHODS: Patients scheduled for THA (n = 195) were randomized into 3 interventions: intravenous (IV) LDEPI plus TXA (Group IV); topical (TP) diluted-epinephrine plus TXA (Group TP); and TXA alone as control (CT) (Group CT)...
November 6, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29107495/oral-vs-intravenous-vs-topical-tranexamic-acid-in-primary-hip-arthroplasty-a-prospective-randomized-double-blind-controlled-study
#9
Ze-Yu Luo, Hao-Yang Wang, Duan Wang, Kai Zhou, Fu-Xing Pei, Zong-Ke Zhou
BACKGROUND: Tranexamic acid (TXA) has demonstrated efficacy in reducing blood loss, reduction in hemoglobin, and blood transfusion requirements in primary total hip arthroplasty (THA). The optimal mode of TXA administration for patients undergoing primary THA is unclear. The purpose of this randomized controlled trial is to determine whether oral administration of TXA was superior to intravenous or topical routes in these patients. METHODS: In this double-blinded, placebo-controlled trial, patients undergoing primary THA were randomized to oral (2 g TXA orally 2 hours preoperatively), intravenous (20 mg/kg intravenous TXA bolus 5 minutes before the incision), or topical (2 g TXA applied topically) TXA groups...
October 6, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29106076/rivaroxaban-reversal-with-prothrombin-complex-concentrate-or-tranexamic-acid-in-healthy-volunteers
#10
J H Levy, K T Moore, M D Neal, D Schneider, V S Marcsisin, J Ariyawansa, J I Weitz
BACKGROUND: Oral factor Xa inhibitors such as rivaroxaban are widely used, but specific reversal agents are lacking. Although 4-factor-prothrombin complex concentrate (4F-PCC) and tranexamic acid (TXA) are sometimes used to manage serious bleeding, their efficacy is unknown. Prior studies in healthy subjects taking rivaroxaban revealed that 4F-PCC partially reverses the prolonged prothrombin time (PT), and fully restores endogenous thrombin potential (ETP). The effect of TXA has not been evaluated...
November 6, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29099887/use-of-intravenous-tranexamic-acid-improves-early-ambulation-after-total-knee-arthroplasty-and-anterior-and-posterior-total-hip-arthroplasty
#11
Eugene S Krauss, MaryAnne Cronin, Sanjeev J Suratwala, Paul Enker, Lisa Rosen, Ayal Segal
We conducted a retrospective cohort study (N = 477) to determine if use of intravenous tranexamic acid (TXA) improves early ambulation and reduces blood loss after total knee arthroplasty and anterior and posterior total hip arthroplasty. Mean (SD) patient age was 66.5 (10.1) years. For all 3 procedures, early ambulation was significantly better in the TXA group than in the no-TXA group at postoperative days 1 and 2, and, over time, reductions in hemoglobin and hematocrit were statistically significantly lower in the TXA group than in the no-TXA group...
September 2017: American Journal of Orthopedics
https://www.readbyqxmd.com/read/29099738/anti-inflammatory-effect-of-malva-sylvestris-sida-cordifolia-and-pelargonium-graveolens-is-related-to-inhibition-of-prostanoid-production
#12
Cleverson Antonio Ferreira Martins, Michel Leandro Campos, Ana Carolina Irioda, Dile Pontarolo Stremel, Angela Cristina Leal Badaró Trindade, Roberto Pontarolo
The ability of plant extracts and preparations to reduce inflammation has been proven by different means in experimental models. Since inflammation enhances the release of specific mediators, inhibition of their production can be used to investigate the anti-inflammatory effect of plants widely used in folk medicine for this purpose. The study was performed for leaves and flowers of Malva sylvestris, and leaves of Sida cordifolia and Pelargonium graveolens. These are three plant species known in Brazil as Malva...
November 3, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29092982/multiple-boluses-of-intravenous-tranexamic-acid-to-reduce-hidden-blood-loss-and-the-inflammatory-response-following-enhanced-recovery-primary-total-hip-arthroplasty-a-randomised-clinical-trial
#13
J Xie, Q Hu, J Ma, Q Huang, F Pei
AIMS: The aim of this study was to examine the efficacy and safety of multiple boluses of intravenous (IV) tranexamic acid (TXA) on the hidden blood loss (HBL) and inflammatory response following primary total hip arthroplasty (THA). PATIENTS AND METHODS: A total of 150 patients were allocated randomly to receive a single bolus of 20 mg/kg IV TXA before the incision (group A), a single bolus followed by a second bolus of 1 g IV-TXA three hours later (group B) or a single bolus followed by two boluses of 1 g IV-TXA three and six hours later (group C)...
November 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/29078788/the-efficacy-of-tranexamic-acid-using-oral-administration-in-total-knee-arthroplasty-a-systematic-review-and-meta-analysis
#14
Lu-Kai Zhang, Jian-Xiong Ma, Ming-Jie Kuang, Jie Zhao, Bin Lu, Ying Wang, Xin-Long Ma, Zheng-Rui Fan
BACKGROUND: Total knee arthroplasty (TKA) is gradually regarded as an effective choice for end-stage osteoarthritis or rheumatic arthritis. In the past, the management of tranexamic acid (TXA) using intravenous injection or topical application has been extensively researched. However, several studies have reported that oral TXA has an effect on blood loss. Therefore, a meta-analysis should be performed to determine whether oral TXA helps to prevent blood loss. METHODS: Randomized controlled trials or retrospective cohort studies about relevant studies were searched in PubMed (1996-April 2017), Embase (1980-April 2017), and the Cochrane Library (CENTRAL, April 2017)...
October 27, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29074420/effect-of-tranexamic-acid-on-prevention-of-hemorrhagic-mass-growth-in-patients-with-traumatic-brain-injury
#15
Esmaeil Fakharian, Masoumeh Abedzadeh-Kalahroudi, Fatemeh Atoof
BACKGROUND: Intracranial hemorrhage (ICH) is a common complication of traumatic brain injury (TBI). The purpose of this study is evaluation of the effect of Tranexamic Acid (TXA) on hemorrhagic mass growth in TBI patients. PATIENTS AND METHODS: In this randomized double blind clinical trial, 149 patients with TBI and any kind of blood on their CT scan, enrolled to the study and randomly allocated to receiving TXA or placebo. After 24 hours, CT scan was repeated for assessing the changes in hemorrhage, new bleeding, and mass effects of the blood on the brain tissue...
October 23, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29074352/-safety-and-efficacy-of-intravenous-tranexamic-acid-in-endoscopic-transurethral-resections-in-urology-prospective-randomized-trial
#16
A Jendoubi, A Malouch, A Bouzouita, Y Riahi, H Necib, S Ghedira, M Houissa
BACKGROUND: Endoscopic urological procedures (transurethral resection of the prostate TURP/transurethral resection of bladder tumor TURBT) are not without risk of significant bleeding. This risk is due to the vascular nature of the tissues and their high levels of fibrinolytic enzymes in the tissues and urine. This study was conducted to evaluate the safety and efficacy of the antifibrinolytic agent tranexamic acid (TXA) in reducing blood loss in patients undergoing TURP/TURBT and transfusion requirement...
October 23, 2017: Progrès en Urologie
https://www.readbyqxmd.com/read/29071337/evaluation-of-military-use-of-tranexamic-acid-and-associated-thromboembolic-events
#17
Luke R Johnston, Carlos J Rodriguez, Eric A Elster, Matthew J Bradley
Importance: Since publication of the CRASH-2 and MATTERs studies, the US military has included tranexamic acid (TXA) in clinical practice guidelines. While TXA was shown to decrease mortality in trauma patients requiring massive transfusion, improper administration and increased risk of venous thromboembolism remain a concern. Objective: To determine the appropriateness of TXA administration by US military medical personnel based on current Joint Trauma System clinical practice guidelines and to determine if TXA administration is associated with venous thromboembolism...
October 25, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/29049210/topical-use-of-tranexamic-acid-can-effectively-decrease-hidden-blood-loss-during-posterior-lumbar-spinal-fusion-surgery-a-retrospective-study
#18
Zhinan Ren, Shugang Li, Lin Sheng, Qianyu Zhuang, Zheng Li, Derong Xu, Xin Chen, Pengxiang Jiang, Xiao Zhang
In spinal fusion surgery, total blood loss (TBL) is composed of visible blood loss from the surgical field and wound drainage, and hidden blood loss (HBL). Until now, no published studies exist reporting the effect of topical use of tranexamic acid (tTXA) on HBL in patients undergoing posterior lumbar spinal fusion surgery. This study aimed to explore the effect of tTXA on HBL during primary posterior lumbar spinal fusion surgery. Between September 2014 and September 2016, 100 adult patients (age > 18 years) with lumbar disc herniation or lumbar spinal stenosis undergoing primary posterior lumbar instrumented spinal fusions at 1 institution were divided into tTXA and control groups...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29049195/the-efficacy-of-combined-intra-articular-and-intravenous-tranexamic-acid-for-blood-loss-in-primary-total-knee-arthroplasty-a-meta-analysis
#19
REVIEW
Zhao Wang, Xiaofei Shen
BACKGROUND: This meta-analysis aimed to illustrate the efficacy and safety of combined topical and intravenous (IV) tranexamic acid (TXA) for blood loss control in primary total knee arthroplasty (TKA) patients. METHODS: In April 2017, a systematic computer-based search was conducted in PubMed, EMBASE, Web of Science, Cochrane Database of Systematic Reviews, and Google database. Data on patients prepared for TKA surgery in studies that compared combined topical and IV TXA versus placebo, topical, or IV TXA alone were retrieved...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29040203/the-temporal-response-and-mechanism-of-action-of-tranexamic-acid-in-endothelial-glycocalyx-degradation
#20
Mark E Diebel, Jonathan V Martin, David M Liberati, Lawrence N Diebel
BACKGROUND: The endothelial glycocalyx (GCX) plays an important role in vascular barrier function. Damage to the GCX occurs due to a variety of causes including hypoxia, ischemia-reperfusion, stress related sympathoadrenal activation, and inflammation. Tranexamic acid (TXA) may prevent GCX degradation. The therapeutic window for TXA administration and the mechanism of action has been under review. Membrane-anchored proteases (sheddases) are key components in endothelial cell biology including the regulation of vascular permeability...
October 16, 2017: Journal of Trauma and Acute Care Surgery
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