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Stress in dementia

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https://www.readbyqxmd.com/read/29240549/interpreter-mediated-cognitive-assessments-who-wins-and-who-loses
#1
Betty Haralambous, Jean Tinney, Dina LoGiudice, Sook Meng Lee, Xiaoping Lin
OBJECTIVES: The number of people with dementia from culturally and linguistically diverse (CALD) backgrounds is increasing dramatically in Australia. Accurate cognitive assessments of people from CALD backgrounds can be achieved with the use of skilled interpreters. This study aimed to explore the experience of interpreter-mediated assessments from the perspectives of clinicians, interpreters and carers. METHODS: Consultations with interpreters, clinicians and carers were conducted through individual interviews and focus groups...
November 16, 2017: Clinical Gerontologist
https://www.readbyqxmd.com/read/29239283/effects-of-stress-on-emotional-memory-in-patients-with-alzheimer-s-disease-and-in-healthy-elderly
#2
María Gómez-Gallego, Juan Gómez-García
OBJECTIVE: We aimed at examining the relation between stress markers (cortisol levels and state anxiety) with memory for emotional information in AD patients and in healthy elderly. DESIGN, SETTING, AND PARTICIPANTS: Baseline and changes in stress markers during memory testing were assessed in a sample of 98 elderly (46 mild-to-moderate Alzheimer's disease patients and 52 controls) recruited from dementia day centers and adult day centers, respectively. MEASUREMENTS: Salivary cortisol, state anxiety, and measures of immediate recall and delayed recognition using the International Affective Pictures System...
December 14, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/29237377/diet-and-brain-health-which-role-for-polyphenols
#3
Vanessa Castelli, Davide Grassi, Raffaella Bocale, Michele d'Angelo, Andrea Antonosante, Annamaria Cimini, Claudio Ferri, Giovambattista Desideri
BACKGROUND: The aging of western societies is leading to a dramatic increase in the prevalence of chronic conditions, threatening the health status and then the sustainability of our healthcare systems. In particular, dementia is being increasingly recognized as a public health priority, given its enormous socioeconomic burdens further amplified by the absence of treatments really effective in improving the clinical course of the disease. METHODS: The question of whether some degree of cognitive deterioration is an inevitable part of aging or should be considered as a pathological pre-stage of dementia is currently debated...
December 12, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29236621/helping-hispanic-dementia-caregivers-cope-with-stress-using-technology-based-resources
#4
Bruno Kajiyama, Gerardo Fernandez, Elizabeth A Carter, Marika B Humber, Larry W Thompson
OBJECTIVES: The objectives of this study were to develop and evaluate a culturally appropriate intervention for Hispanic/Latino caregivers of individuals with dementia, using a structured online program without professional involvement to improve well-being, decrease stress, and reduce depression. METHODS: The Webnovela Mirela, an online Spanish-language telenovela, was designed specifically to teach caregivers how to cope with dementia caregiving. A prototype of Webnovela Mirela was tested in a pilot study with 25 Hispanic/Latino dementia caregivers, 19 of whom completed the study...
September 15, 2017: Clinical Gerontologist
https://www.readbyqxmd.com/read/29235432/impact-of-informal-caregiving-on-cognitive-function-and-well-being-in-canada
#5
Sasha Mallya, Alexandra J Fiocco
BACKGROUND: With a rise in the aging population and a consequential rise in persons diagnosed with dementia comes an increase in the number of informal caregivers who are caring for a loved one. The objective of the proposed study was to assess the neurocognitive and psychological effects of caring for a person with dementia or a related neurodegenerative disease in a sample of Canadian informal caregivers. METHODS: Fifty-seven informal caregivers of a person with dementia or a related neurodegenerative disease (mean age = 66...
December 13, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/29235393/needs-of-people-with-advanced-dementia-in-their-final-phase-of-life-a-multi-perspective-qualitative-study-in-nursing-homes
#6
Holger Schmidt, Yvonne Eisenmann, Heidrun Golla, Raymond Voltz, Klaus Maria Perrar
BACKGROUND: People with advanced dementia present an important target group for palliative care. They suffer a range of symptoms, and their verbal communication abilities are highly restricted. At present, little is known about their needs in the final phase of life. AIM: To identify the needs of people with advanced dementia in their final phase of life and to explore the aspects relevant to first recognize and then meet these needs. DESIGN: Multi-perspective qualitative study using grounded theory methodology conducting group discussions, individual interviews, and participant observation...
December 1, 2017: Palliative Medicine
https://www.readbyqxmd.com/read/29234406/amelioration-of-scopolamine-induced-learning-and-memory-impairment-by-%C3%AE-pinene-in-c57bl-6-mice
#7
Gil-Yong Lee, Chan Lee, Gyu Hwan Park, Jung-Hee Jang
Increasing evidence suggests that neurodegenerative disorders such as Alzheimer's disease (AD) are mediated via disruption of cholinergic neurons and enhanced oxidative stress. Therefore, attention has been focused on searching for antioxidant phytochemicals for the prevention and/or treatment of AD through their ability to fortify cholinergic function and antioxidant defense capacity. In this study, we have investigated the neuroprotective effect of α-pinene (APN) against learning and memory impairment induced by scopolamine (SCO, 1 mg/kg, i...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29231914/determinants-of-late-life-depression-in-residents-of-long-term-care-facility
#8
Urszula Horwath, Katarzyna Szczerbińska
Mental disorders, such as dementia and depression, are beside chronic somatic diseases, the most common problem in residents of longterm care facilities (LTCF). Late-life depression refers to depressive symptoms that arise in adults older than 65 years. According to literature review, older people tend to differ from middle-aged adults in presentation of depression. AIM: Mental disorders, such as dementia and depression, are beside chronic somatic diseases, the most common problem in residents of longterm care facilities (LTCF)...
November 23, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29223192/training-needs-for-dementia-care-in-china-from-the-perspectives-of-mental-health-providers-who-what-and-how
#9
Ling Xu, Hsin-Yi Hsiao, Wenchen Denq, Iris Chi
BACKGROUND: Acknowledging increasing demand of dementia care for patients in China, this paper aims to understand the training needs of dementia care from the perspectives of mental health providers by examining who should be the trainees, what should be the contents of training, and how to deliver the training in China. METHODS: Using purposive sampling, data were gathered via four focus group discussions with 40 mental health providers in Beijing, China, in 2011...
December 10, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/29223191/iterating-a-framework-for-the-prevention-of-caregiver-depression-in-dementia-a-multi-method-approach
#10
Jiangbo Ying, Philip Yap, Mihir Gandhi, Tau Ming Liew
BACKGROUND: Dementia caregiving is often stressful and depression in family caregivers is not uncommon. As caregiver depression can have significant effects, there is a need for preventive efforts which are consistent with the extensive literature. We sought to consolidate the wide range of evidence (using a multi-method approach) into a simple framework that can guide the prevention of caregiver depression. METHODS: Using multiple logistic regression, we derived the predictors of caregiver depression from an empirical dataset containing key information and depression scores (based on the Center-for-Epidemiological-Studies-Depression-Scale) of 394 family caregivers...
December 10, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/29223185/aiding-medical-professionals-in-fitness-to-drive-screenings-for-elderly-drivers-development-of-an-office-based-screening-tool
#11
Judith H J Urlings, Ariane Cuenen, Tom Brijs, Mark Lutin, Ellen M M Jongen
BACKGROUND: Elderly drivers are an increasing group in society. Previous research has found that functional and cognitive abilities are more important for driving abilities than biological age. In an attempt to conserve independent mobility for elderly drivers, many researchers have focused on elderly drivers diagnosed with cognitive decline (mild cognitive impairment or mild Dementia). This study is the first to focus on elderly drivers with cognitive complaints or suspected of diminished fitness to drive by an (in)formal caregiver as an at-risk group...
December 10, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/29223171/caregiver-burden-sleep-quality-depression-and-anxiety-in-dementia-caregivers-a-comparison-of-frontotemporal-lobar-degeneration-dementia-with-lewy-bodies-and-alzheimer-s-disease
#12
Shuai Liu, Jing Liu, Xiao-Dan Wang, Zhihong Shi, Yuying Zhou, Jing Li, Tao Yu, Yong Ji
BACKGROUND: Very few recent studies are available that compare caregiver burden, sleep quality, and stress in caregivers of different types of dementia. We aimed to investigate caregiver burden, sleep quality, and stress in caregivers of patients with frontotemporal lobar degeneration and dementia with Lewy bodies, as compared with caregivers of patients with Alzheimer's disease. METHODS: This study was carried out from March 2011 to January 2014. In total, 492 dyads of patient and caregiver (frontotemporal lobar degeneration, n = 131; dementia with Lewy bodies, n = 36; Alzheimer's disease, n = 325) participated in this study...
December 10, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/29222490/ran-translation-at-c9orf72-associated-repeat-expansions-is-selectively-enhanced-by-the-integrated-stress-response
#13
Katelyn M Green, M Rebecca Glineburg, Michael G Kearse, Brittany N Flores, Alexander E Linsalata, Stephen J Fedak, Aaron C Goldstrohm, Sami J Barmada, Peter K Todd
Repeat-associated non-AUG (RAN) translation allows for unconventional initiation at disease-causing repeat expansions. As RAN translation contributes to pathogenesis in multiple neurodegenerative disorders, determining its mechanistic underpinnings may inform therapeutic development. Here we analyze RAN translation at G4C2 repeat expansions that cause C9orf72-associated amyotrophic lateral sclerosis and frontotemporal dementia (C9RAN) and at CGG repeats that cause fragile X-associated tremor/ataxia syndrome...
December 8, 2017: Nature Communications
https://www.readbyqxmd.com/read/29221697/prevalence-of-mental-health-disorders-in-elderly-u-s-military-veterans-a-meta-analysis-and-systematic-review
#14
Victoria Williamson, Sharon A M Stevelink, Karla Greenberg, Neil Greenberg
OBJECTIVE: Older veterans may be vulnerable to mental health problems. Meta-analytic and systematic review methods sought to determine the prevalence rate of mental health disorders in older military veterans (≥65 years). METHODS: Eleven studies were eligible, and meta-analyses of veteran depression, substance abuse, post-traumatic stress disorder (PTSD), anxiety, dementia, bipolar disorder, and schizophrenia were conducted. RESULTS: Although conducted exclusively with U...
November 8, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29216908/clinical-and-neuropathological-features-of-als-ftd-with-tia1-mutations
#15
Veronica Hirsch-Reinshagen, Cyril Pottier, Alexandra M Nicholson, Matt Baker, Ging-Yuek R Hsiung, Charles Krieger, Pheth Sengdy, Kevin B Boylan, Dennis W Dickson, Marsel Mesulam, Sandra Weintraub, Eileen Bigio, Lorne Zinman, Julia Keith, Ekaterina Rogaeva, Sasha A Zivkovic, David Lacomis, J Paul Taylor, Rosa Rademakers, Ian R A Mackenzie
Mutations in the stress granule protein T-cell restricted intracellular antigen 1 (TIA1) were recently shown to cause amyotrophic lateral sclerosis (ALS) with or without frontotemporal dementia (FTD). Here, we provide detailed clinical and neuropathological descriptions of nine cases with TIA1 mutations, together with comparisons to sporadic ALS (sALS) and ALS due to repeat expansions in C9orf72 (C9orf72+). All nine patients with confirmed mutations in TIA1 were female. The clinical phenotype was heterogeneous with a range in the age at onset from late twenties to the eighth decade (mean = 60 years) and disease duration from one to 6 years (mean = 3 years)...
December 7, 2017: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/29210074/white-matter-degeneration-in-vascular-and-other-ageing-related-dementias
#16
REVIEW
Yoshika Hase, Karen Horsburgh, Masafumi Ihara, Raj N Kalaria
Advances in neuroimaging have enabled greater understanding of the progression of cerebral degenerative processes associated with ageing-related dementias. Leukoaraiosis or rarefied white matter (WM) originally described on computed tomography is one of the most prominent changes which occurs in older age. White matter hyperintensities (WMH) evident on magnetic resonance imaging have become commonplace to describe WM changes in relation to cognitive dysfunction, types of stroke injury, cerebral small vessel disease and neurodegenerative disorders including Alzheimer's disease...
December 6, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29209218/nootropic-and-neuroprotective-effects-of-dichrocephala-integrifolia-on-scopolamine-mouse-model-of-alzheimer-s-disease
#17
Nadège E Kouémou, Germain S Taiwe, Fleur C O Moto, Simon Pale, Gwladys T Ngoupaye, Jacqueline S K Njapdounke, Gisèle C N Nkantchoua, David B Pahaye, Elisabeth Ngo Bum
Alzheimer's disease the most common form of dementia in the elderly is a neurodegenerative disease that affects 44 millions of people worldwide. The first treatments against Alzheimer's disease are acetylcholinesterase inhibitors; however, these medications are associated with many side effects. Dichrocephala integrifolia is a traditional herb widely used by indigenous population of Cameroon to treat and prevent Alzheimer's disease and for memory improvement. In this study, we evaluated the effect of the decoction prepared from leaves of D...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29206481/age-memory-loss-and-perceptions-of-dementia-in-south-asian-ethnic-minorities
#18
Clarissa M Giebel, Angela Worden, David Challis, David Jolley, Kamaldeep Singh Bhui, Ahmed Lambat, Eleni Kampanellou, Nitin Purandare
BACKGROUND: South Asian older adults are represented less frequently in mainstream mental health services or those for people with dementia. This study aimed to explore in detail the perceptions of dementia (symptoms, causes, consequences, treatments) held by South Asians and to discern how these understandings vary by age and by the self-recognition of memory problems, as these influence help-seeking behaviour. METHODS: Participants were allocated to three groups: younger adults; older adults; and older adults with subjective memory problems...
December 5, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/29199596/insulin-combined-with-glucose-improves-spatial-learning-and-memory-in-aluminum-chloride-induced-dementia-in-rats
#19
Madhavan Nampoothiri, Grandhi Venkata Ramalingayya, Nampurath Gopalan Kutty, Nandakumar Krishnadas, Chamallamudi Mallikarjuna Rao
Therapeutic intervention using drugs against Alzheimer disease is curative clinically. At present, there are no reports on the curative role of insulin in chronic models of dementia. We evaluated the curative role of insulin and its combination with glucose in dementia. We also investigated the impact of treatments on blood glucose to correlate with cognitive deficit. Further, we analyzed the interaction of treatments with the cholinergic system and oxidative stress in memory centers (i.e., hippocampus and frontal cortex)...
2017: Journal of Environmental Pathology, Toxicology and Oncology
https://www.readbyqxmd.com/read/29191219/neurons-derived-from-sporadic-alzheimer-s-disease-ipscs-reveal-elevated-tau-hyperphosphorylation-increased-amyloid-levels-and-gsk3b-activation
#20
Anna Ochalek, Balázs Mihalik, Hasan X Avci, Abinaya Chandrasekaran, Annamária Téglási, István Bock, Maria Lo Giudice, Zsuzsanna Táncos, Kinga Molnár, Lajos László, Jørgen E Nielsen, Bjørn Holst, Kristine Freude, Poul Hyttel, Julianna Kobolák, András Dinnyés
BACKGROUND: Alzheimer's disease (AD) is the most common type of dementia, affecting one in eight adults over 65 years of age. The majority of AD cases are sporadic, with unknown etiology, and only 5% of all patients with AD present the familial monogenic form of the disease. In the present study, our aim was to establish an in vitro cell model based on patient-specific human neurons to study the pathomechanism of sporadic AD. METHODS: We compared neurons derived from induced pluripotent stem cell (iPSC) lines of patients with early-onset familial Alzheimer's disease (fAD), all caused by mutations in the PSEN1 gene; patients with late-onset sporadic Alzheimer's disease (sAD); and three control individuals without dementia...
December 1, 2017: Alzheimer's Research & Therapy
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