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Stress in dementia

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https://www.readbyqxmd.com/read/29679204/efficacy-of-curcumin-for-age-associated-cognitive-decline-a-narrative-review-of-preclinical-and-clinical-studies
#1
REVIEW
Marjana Rahman Sarker, Susan F Franks
Processes such as aberrant redox signaling and chronic low-grade systemic inflammation have been reported to modulate age-associated pathologies such as cognitive impairment. Curcumin, the primary therapeutic component of the Indian spice, Turmeric (Curcuma longa), has long been known for its strong anti-inflammatory and antioxidant activity attributable to its unique molecular structure. Recently, an interest in this polyphenol as a cognitive therapeutic for the elderly has emerged. The purpose of this paper is to critically review preclinical and clinical studies that have evaluated the efficacy of curcumin in ameliorating and preventing age-associated cognitive decline and address the translational progress of preclinical to clinical efficacy...
April 21, 2018: GeroScience
https://www.readbyqxmd.com/read/29677514/phase-separation-of-fus-is-suppressed-by-its-nuclear-import-receptor-and-arginine-methylation
#2
Mario Hofweber, Saskia Hutten, Benjamin Bourgeois, Emil Spreitzer, Annika Niedner-Boblenz, Martina Schifferer, Marc-David Ruepp, Mikael Simons, Dierk Niessing, Tobias Madl, Dorothee Dormann
Cytoplasmic FUS aggregates are a pathological hallmark in a subset of patients with frontotemporal dementia (FTD) or amyotrophic lateral sclerosis (ALS). A key step that is disrupted in these patients is nuclear import of FUS mediated by the import receptor Transportin/Karyopherin-β2. In ALS-FUS patients, this is caused by mutations in the nuclear localization signal (NLS) of FUS that weaken Transportin binding. In FTD-FUS patients, Transportin is aggregated, and post-translational arginine methylation, which regulates the FUS-Transportin interaction, is lost...
April 19, 2018: Cell
https://www.readbyqxmd.com/read/29676814/potential-of-carnosine-a-histamine-precursor-in-rat-model-of-bilateral-common-carotid-artery-occlusion-induced-vascular-dementia
#3
Nidhi Tiwari, Pankaj Bhatia, Amit Kumar, Amteshwar S Jaggi, Nirmal Singh
The present study investigates the potential of Carnosine a histamine precursor, in rat model of bilateral common carotid artery occlusion (BCCAo) induced vascular dementia (VaD). Wistar rats were subjected to BCCAo procedure under anesthesia to induce VaD. The rats were subjected to Morris water-maze (MWM) test (6th day onwards post-surgery). MWM test was employed to assess learning and memory of the animals whereby ELT (escape latency time), TSTQ (time spent in target quadrant) and Path length (distance travelled) taken as important parameters...
April 20, 2018: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/29667698/chronic-stress-social-isolation-and-perceived-loneliness-in-dementia-caregivers
#4
Mariya Kovaleva, Sydney Spangler, Carolyn Clevenger, Kenneth Hepburn
Caregivers of individuals with dementia are at risk for chronic stress and social isolation. These exogenous factors may lead to perceived stress and perceived loneliness-psychosocial endogenous (subjective) elements of caregiving experience. Chronic stress and perceived loneliness may disrupt neuroendocrine and neuroimmunological regulation, creating low-grade systemic inflammation, promoting proinflammatory gene expression, and expediting cellular aging (endogenous physiological factors). These disturbances may enhance caregivers' risk for chronic conditions of inflammatory pathogenesis...
April 17, 2018: Journal of Psychosocial Nursing and Mental Health Services
https://www.readbyqxmd.com/read/29667571/is-it-all-bleak-a-systematic-review-of-factors-contributing-to-relationship-change-in-dementia
#5
Erin R Conway, Brittany Watson, Gemma Tatangelo, Marita McCabe
ABSTRACTBackground:The care of community-dwelling people with dementia often occurs in the context of pre-existing family relationships. The presence of dementia can result in changes to the quality of those relationships. The purpose of this systematic review is to identify factors that enhance or challenge the quality of spousal or offspring relationships in the context of dementia. METHODS: Both qualitative and quantitative studies were included in a systematic review of the literature...
April 18, 2018: International Psychogeriatrics
https://www.readbyqxmd.com/read/29663818/alternative-hypotheses-related-to-alzheimer-s-disease
#6
V Cubinkova, B Valachova, I Uhrinova, V Brezovakova, T Smolek, S Jadhav, N Zilka
Alzheimer's disease represents the most common form of dementia and belongs to the group of neurodegenerative disorders characterized by progressive loss of neurons in the central nervous system. In the pathogenesis of Alzheimer's disease several etiologic and pathogenic factors exist, which lead to the dysfunction of neurotransmitter systems and consequent cognitive decline. Last three decades have delivered a crucial progress leading to better understanding of Alzheimer's disease, however, the exact mechanisms of pathology remain unclear...
2018: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/29663553/rapid-evidence-assessment-of-approaches-to-community-neurological-nursing-care-for-people-with-neurological-conditions-post-discharge-from-acute-care-hospital
#7
REVIEW
Judith Dianne Pugh, Kathleen McCoy, Anne M Williams, Brenda Bentley, Leanne Monterosso
Neurological conditions represent leading causes of non-fatal burden of disease that will consume a large proportion of projected healthcare expenditure. Inconsistent access to integrated healthcare and other services for people with long-term neurological conditions stresses acute care services. The purpose of this rapid evidence assessment, conducted February-June 2016, was to review the evidence supporting community neurological nursing approaches for patients with neurological conditions post-discharge from acute care hospitals...
April 16, 2018: Health & Social Care in the Community
https://www.readbyqxmd.com/read/29663065/-individual-activation-of-dementia-sufferers-in-a-home-setting-a-randomized-controlled-study
#8
Renate Stemmer, Elmar Gräßel, Martin Schmid
BACKGROUND AND OBJECTIVES: The present project investigated the hypothesis that a multimodal individual activation of people with mild to moderate dementia in the home setting during a 6-month intervention period leads to improved everyday practice and cognitive abilities compared to the control group. MATERIAL AND METHODS: Intervention: a practical activation was performed by relatives 6 days per week. Cognitive stimulation took place once a week and was done by an external person...
April 16, 2018: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/29658306/-how-do-they-want-to-know-doctors-perspectives-on-making-and-communicating-a-diagnosis-of-dementia
#9
Cate Bailey, Jemima Dooley, Rose McCabe
Recent drives to facilitate earlier identification of dementia have led to increased memory clinic referrals and diagnoses. This study explored the perspectives of memory clinic doctors on making and delivering diagnoses. Four focus groups were conducted with 13 psychiatrists and two geriatricians in the UK. Transcripts were coded line by line using NVIVO. Thematic analysis identified 39 categories, 18 sub-themes and eight overarching themes. Inter-rater reliability on 31% of the data was 0.89. Increased public awareness of dementia was viewed positively in facilitating access to diagnosis and treatment...
January 1, 2018: Dementia
https://www.readbyqxmd.com/read/29653127/evaluation-of-early-chronic-functional-outcomes-and-their-relationship-to-pre-frontal-cortex-and-hippocampal-pathology-following-moderate-severe-traumatic-brain-injury
#10
Alina Arulsamy, Jason Teng, Holly Colton, Frances Corrigan, Lyndsey Collins-Praino
TBI is a significant risk factor for the development of dementia, with the interaction between structural damage from TBI and neuroinflammation potentially driving this relationship. This study investigated the early chronic post-TBI neuroinflammatory response and its relationship to both neurodegenerative pathology and functional impairment up to 3 months post-injury. Sprague-Dawley rats underwent either sham surgery or the Marmarou model of diffuse moderate-severe TBI. At 1-month and 3-months post-injury, a functional battery encompassing motor function, depressive-like behaviour, anxiety and cognition was performed...
April 10, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29644987/preventing-and-managing-workplace-violence-against-healthcare-workers-in-emergency-departments
#11
Gabriele D'Ettorre, Vincenza Pellicani, Mauro Mazzotta, Annamaria Vullo
BACKGROUND AND AIM: Healthcare workers (HCWs) employed in Emergency Departments (EDs) frequently face with patients becoming violent because of long wait or diseases or under the influence of alcohol or drugs. Globally, workplace violence (WPV) in EDs is a major challenge to safety for HCWs, involving significant consequences to the victims, patients, and healthcare organizations. We reviewed the current literature with the aim to explore the topics focused on and to detect new evidences about approaching the issue of WPV toward HCWs in EDs...
February 21, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29629297/influences-of-pinpoint-plantar-long-wavelength-infrared-light-irradiation-stress-free-therapy-on-chorioretinal-hemodynamics-atherosclerosis-factors-and-vascular-endothelial-growth-factor
#12
Keisou Ishimaru, Takuma Nakajima, Yoshihisa Namiki, Kenji Ryotokuji
Background: We previously reported that pinpoint plantar long-wavelength infrared light irradiation (stress-free therapy; SFT) is useful for alleviating insulin resistance and improving intracranial blood flow in patients with type 2 diabetes mellitus. This study was undertaken to evaluate the influences of SFT on chorioretinal hemodynamics (retinal artery and vein blood flows) as well as atherosclerosis-related factors (TG, LDL-C) and VEGF in patients with dyslipidemia. Methods: Four patients with dyslipidemia received 15-minute irradiation with a stress-free apparatus (far-infrared wavelength, 30 mW)...
March 2018: Integrative Medicine Research
https://www.readbyqxmd.com/read/29628143/stress-granule-assembly-disrupts-nucleocytoplasmic-transport
#13
Ke Zhang, J Gavin Daigle, Kathleen M Cunningham, Alyssa N Coyne, Kai Ruan, Jonathan C Grima, Kelly E Bowen, Harsh Wadhwa, Peiguo Yang, Frank Rigo, J Paul Taylor, Aaron D Gitler, Jeffrey D Rothstein, Thomas E Lloyd
Defects in nucleocytoplasmic transport have been identified as a key pathogenic event in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) mediated by a GGGGCC hexanucleotide repeat expansion in C9ORF72, the most common genetic cause of ALS/FTD. Furthermore, nucleocytoplasmic transport disruption has also been implicated in other neurodegenerative diseases with protein aggregation, suggesting a shared mechanism by which protein stress disrupts nucleocytoplasmic transport. Here, we show that cellular stress disrupts nucleocytoplasmic transport by localizing critical nucleocytoplasmic transport factors into stress granules, RNA/protein complexes that play a crucial role in ALS pathogenesis...
April 2, 2018: Cell
https://www.readbyqxmd.com/read/29627943/therapeutic-potential-of-vitamin-e-and-its-derivatives-in-traumatic-brain-injury-associated-dementia
#14
Jan Dobrovolny, Martin Smrcka, Julie Bienertova-Vasku
Traumatic brain injury is one of the most common causes for intervention in neurosurgery. Apart from its acute consequence, it can represent a further burden on individuals as well as society by being associated with significant comorbidity-mainly early-onset dementia. Oxidative stress is one of the crucial mechanisms conferring the damage to nervous tissue, and it is believed it could be, to some extent, influenced by dietary composition, largely by antioxidants contained in the diet. Under stressful conditions, cell-derived reactive oxygen species in the brain can induce the formation of lipid peroxides and the shifting of redox homeostasis...
April 7, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29626801/study-protocol-a-montessori-approach-to-dementia-related-non-residential-respite-services-in-australia
#15
Andrew Hanna, James Donnelly, Christina Aggar
Given the social burden and significant cost of dementia care in Australia, finding evidence-based approaches that improve outcomes, maintain independence, and reduce the impact on patients and families is essential. Finding effective ways to train and assist the healthcare staff who support these individuals is also critical, as they are considered to be at risk of workplace stress, burnout, and other psychological disturbances which negatively affects standards of care. The current paper describes a protocol for evaluating the effects of a Montessori-based approach to dementia care, in non-residential respite centres...
March 27, 2018: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29618426/anticataleptic-activity-of-zamzam-water-in-chlorpromazine-induced-animal-model-of-parkinson-disease
#16
Bushra Riaz, Rahila Ikram, Bushra Sikandar
Parkinsonism is characterized by rest tremor, inflexibility, balance debilitation, slow motion and dementia. It is known to be caused by the deficiency of dopaminergic neurons in nigrostriatal pathway. Different studies propose that oxidative burden may be included in the apoptotic process in parkisnons disease. Zamzam water being alkaline in composition may diminish the oxidative stress and hence relieve the symptoms. Therefore, the purpose of this study was to explore the neuroprotective effect of zamzam water in chlorpromazine induced animal model of Parkinsonism...
March 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29617373/emotional-reactivity-to-daily-life-stress-in-spousal-caregivers-of-people-with-dementia-an-experience-sampling-study
#17
Rosalia J M van Knippenberg, Marjolein E de Vugt, Rudolf W Ponds, Frans R J Verhey, Inez Myin-Germeys
INTRODUCTION: Caregivers differ in their emotional response when facing difficult situations during the caregiving process. Individual differences in vulnerabilities and resources could play an exacerbating or buffering role in caregivers' reactivity to daily life stress. This study examines which caregiver characteristics modify emotional stress reactivity in dementia caregivers. METHODS: Thirty caregivers collected momentary data, as based on the experience sampling methodology, to assess (1) appraised subjective stress related to events and minor disturbances in daily life, and (2) emotional reactivity to these daily life stressors, conceptualized as changes in negative affect...
2018: PloS One
https://www.readbyqxmd.com/read/29616602/correlates-of-nursing-care-burden-among-institutionalized-patients-with-dementia
#18
Meng Sun, Brian J Mainland, Tisha J Ornstein, Gwen Li Sin, Nathan Herrmann
ABSTRACTBackground:The stress associated with care of patients with dementia has led to high nursing staff turnover. This study aims to explore patient factors that are related to nursing burden. METHODS: The present study examined nursing care burden related to 55 institutionalized dementia patients using the Modified Nursing Care Assessment Scale (M-NCAS). Cognition was assessed with the Severe Impairment Battery (SIB), activities of daily living (ADLs) were measured with the Alzheimer's Disease Functional Assessment of Change Scale (ADFACS), aggression was measured with the Aggressive Behavior Scale (ABS), and the Charlson Comorbidity Index (CCI) was used to assess medical comorbidity...
April 4, 2018: International Psychogeriatrics
https://www.readbyqxmd.com/read/29614666/post-traumatic-stress-disorder-heralding-the-onset-of-semantic-frontotemporal-dementia
#19
Laura Bonanni, Raffaella Franciotti, Giovanni Martinotti, Federica Vellante, Maria Elena Flacco, Massimo Di Giannantonio, Astrid Thomas, Marco Onofrj
BACKGROUND: Post traumatic stress disorder (PTSD) is associated with cognitive decline. The dementia type following PTSD is unclear. OBJECTIVE: To assess whether PTSD is associated with a specific dementia. METHODS: Prospective study: 46 PTSD patients (DSM-IV-TR) were followed for 6-10 years with clinical, neuropsychological, imaging evaluations for possible development of dementia.Retrospective study:849 dementia patients followed during 1999-2014 (509 Alzheimer's disease, AD; 207 dementia with Lewy bodies, DLB; 90 vascular dementia, VaD; 43 frontotemporal dementia, FTD) and 287 patients with any neurological condition (including patients with/without dementia) were evaluated for the presence of PTSD in their history...
March 24, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29614663/sulforaphane-inhibits-the-generation-of-amyloid-%C3%AE-oligomer-and-promotes-spatial-learning-and-memory-in-alzheimer-s-disease-ps1v97l-transgenic-mice
#20
Ting-Ting Hou, He-Yun Yang, Wei Wang, Qiao-Qi Wu, Yuan-Ruhua Tian, Jian-Ping Jia
Abnormal amyloid-β (Aβ) aggregates are a striking feature of Alzheimer's disease (AD), and Aβ oligomers have been proven to be crucial in the pathology of AD. Any intervention targeting the generation or aggregation of Aβ can be expected to be useful in AD treatment. Oxidative stress and inflammation are common pathological changes in AD that are involved in the generation and aggregation of Aβ. In the present study, 6-month-old PS1V97L transgenic (Tg) mice were treated with sulforaphane, an antioxidant, for 4 months, and this treatment significantly inhibited the generation and aggregation of Aβ...
2018: Journal of Alzheimer's Disease: JAD
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