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Communication and Alzheimer's disease

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https://www.readbyqxmd.com/read/29457487/dementia-management-strategies-associated-with-neuropsychiatric-symptoms-of-elderly-people-with-alzheimer-s-disease
#1
Lais Lopes Delfino, Ricardo Shoiti Komatsu, Caroline Komatsu, Anita Liberalesso Neri, Meire Cachioni
This study aims to investigate the association between management and communication strategies and the presence of neuropsychiatric symptoms presented by elderly people with Alzheimer's disease. One hundred and thirty-four family caregivers answered a questionnaire with socio-demographic data and questions regarding the care context, the Small Communication Strategies Scale, the Dementia Management Strategy Scale, and the Neuropsychiatric Inventory. Caregivers used the criticism management strategy more when the elderly presented hallucination, agitation, depression, anxiety, irritability, nighttime behavior, and appetite abnormalities...
January 1, 2018: Dementia
https://www.readbyqxmd.com/read/29451587/diagnosing-dementia-in-lower-educated-older-persons-validation-of-a-brazilian-portuguese-version-of-the-rowland-universal-dementia-assessment-scale-rudas
#2
Narahyana B de Araujo, Thomas R Nielsen, Knut Engedal, Maria L Barca, Evandro S Coutinho, Jerson Laks
OBJECTIVE: To validate the Rowland Universal Dementia Assessment Scale for use in Brazil (RUDAS-BR). METHODS: We first completed an English-Brazilian Portuguese translation and back-translation of the RUDAS. A total of 135 subjects over 60 years of age were included: 65 cognitively healthy and 70 with Alzheimer's disease (AD) according to the DSM-IV and Neurological and Communicative Disorders and Stroke/Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA) criteria...
February 15, 2018: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/29443064/assessment-of-social-transmission-of-food-preferences-behaviors
#3
Ann Van der Jeugd, Rudi D'Hooge
Olfactory recognition deficits are suggested to be able to serve as clinical marker to differentiate Alzheimer's disease (AD) subjects from healthy aging groups. For example, olfactory dysfunction in AD can present as impairment in olfactory recognition, emerging during early stages of the disease and worsening while the disease progresses. The social transmission of food preferences (STFP) task is based on a rudimentary form of communication between rodents concerning distant foods dependent on the transmission of olfactory cues...
January 25, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29439325/prediction-and-early-detection-of-alzheimer-s-dementia-professional-disclosure-practices-and-ethical-attitudes
#4
Mark Schweda, Anna Kögel, Claudia Bartels, Jens Wiltfang, Anja Schneider, Silke Schicktanz
BACKGROUND: Biomarker-supported testing for preclinical and prodromal Alzheimer's disease (AD) finds its way into clinical practice. Professional attitudes and practices regarding disclosure and ethical issues are controversial in many countries. OBJECTIVES: Against this background, the objective was to survey the actual practice and the attitudes of physicians in German hospitals and memory clinics in order to explore possible practical insecurities and ethical concerns...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29423001/hypoxia-increases-amyloid-%C3%AE-level-in-exosomes-by-enhancing-the-interaction-between-cd147-and-hook1
#5
Jun-Chao Xie, Xiao-Ye Ma, Xiao-Hui Liu, Jia Yu, Yi-Chen Zhao, Yan Tan, Xue-Yuan Liu, Yan-Xin Zhao
Hypoxia promotes the accumulation of amyloid-β (Aβ), which is related to the pathogenesis of Alzheimer's disease (AD). CD147 is considered as an additional subunit of γ-secretase regulated by hypoxia, and has been identified in exosomes. Aβ is also found in exosomes that participate in the intercellular communication and amyloids propagation. This study was to investigate the role of CD147 in hypoxia-induced accumulation of Aβ in exosomes. Our results showed that hypoxia increased the levels of Aβ40 and Aβ42 in exosomes and enhanced the interaction between CD147 and Hook1 in SH-SY5YAPP695 cells...
2018: American Journal of Translational Research
https://www.readbyqxmd.com/read/29406141/blending-the-liberal-arts-and-nursing-creating-a-portrait-for-the-21st-century
#6
Wendy Carter Kooken, Noël Kerr
The liberal arts and sciences serve as a core part of the educational discipline in nursing curriculum and are believed to undergird abilities for critical-thinking, creativity, and holistic care (Hermann, 2004; McKie, 2012). Over time, science has taken on a more central role in nursing education, despite the acknowledged importance and contributions of liberal arts. The humanities are an essential part of liberal arts education and generally include disciplines such as history, literature, religion, philosophy, architecture, or fine arts (e...
January 2018: Journal of Professional Nursing: Official Journal of the American Association of Colleges of Nursing
https://www.readbyqxmd.com/read/29402165/a-deterioration-in-hearing-is-associated-with-functional-and-cognitive-impairments-difficulty-with-communication-and-greater-health-instability
#7
Nicole Williams, Dawn M Guthrie, Jacob G S Davidson, Kathryn Fisher, Lauren E Griffith
OBJECTIVES: To examine the relationship between hearing deterioration and several health-related outcomes among home care clients in Ontario. DESIGN: Longitudinal analysis was completed for clients with at least two comprehensive assessments. Hearing status, based on a single item, ranged from zero (no impairment) to three (highly impaired). Hearing deterioration was defined as at least a 1-point decline between subsequent assessments. RESULTS: Seven percent experienced a 1-point deterioration in hearing and roughly 1% had a 2/3-point decline...
February 1, 2018: Journal of Applied Gerontology: the Official Journal of the Southern Gerontological Society
https://www.readbyqxmd.com/read/29387453/advancing-care-for-family-caregivers-of-persons-with-dementia-through-caregiver-and-community-partnerships
#8
Carole L White, Kristen J Overbaugh, Carolyn E Z Pickering, Bridgett Piernik-Yoder, Debbie James, Darpan I Patel, Frank Puga, Lark Ford, James Cleveland
Background: There are currently 15 million Americans who provide over 80% of the care required by their family members with Alzheimer's disease and other dementias. Yet care for caregivers continues to be fragmented and few evidence-based interventions have been translated into routine clinical care and therefore remain inaccessible to most family caregivers. To address this gap, the Caring for the Caregiver program is being developed at UT Health San Antonio, School of Nursing to improve support services and health outcomes for family caregivers...
2018: Research Involvement and Engagement
https://www.readbyqxmd.com/read/29368117/beyond-v40-31-narrative-phenomenology-of-wandering-in-autism-and-dementia
#9
Olga Solomon, Mary C Lawlor
Research on autism spectrum disorder (ASD) and on Alzheimer's Disease (AD) and other types of dementia describes a behaviour called 'wandering', a term that denotes movement through space lacking intention or exact destination, as when a person is disoriented or not self-aware. In the U.S., 'wandering' in both ASD and AD has been examined mostly from a management and prevention perspective. It prioritizes safety while primarily overlooking personal experiences of those who 'wander' and their families, thus limiting the range of potentially effective strategies to address this issue...
January 24, 2018: Culture, Medicine and Psychiatry
https://www.readbyqxmd.com/read/29361745/microglia-and-aging-the-role-of-the-trem2-dap12-and-cx3cl1-cx3cr1-axes
#10
REVIEW
Carmen Mecca, Ileana Giambanco, Rosario Donato, Cataldo Arcuri
Depending on the species, microglial cells represent 5-20% of glial cells in the adult brain. As the innate immune effector of the brain, microglia are involved in several functions: regulation of inflammation, synaptic connectivity, programmed cell death, wiring and circuitry formation, phagocytosis of cell debris, and synaptic pruning and sculpting of postnatal neural circuits. Moreover, microglia contribute to some neurodevelopmental disorders such as Nasu-Hakola disease (NHD), and to aged-associated neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), and others...
January 22, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29345092/-known-unknowns-examining-the-burden-of-neurocognitive-impairment-in-the-end-stage-renal-failure-population
#11
REVIEW
Scott Wilson, Arup Dhar, Peter Tregaskis, Gavin Lambert, David Barton, Rowan Walker
The burden of neurocognitive impairment (NCI) in patients receiving maintenance dialysis represents a spectrum of deficits across multiple cognitive domains which are associated with hospitalisation, reduced quality-of-life, mortality and forced decision-making around dialysis withdrawal. Point prevalence data suggests that dialysis patients manifest NCI at rates 3-5 fold higher than the general population with executive function the most commonly affected cognitive domain. The unique physiology of the renal failure state and maintenance dialysis appears to drive an excess of vascular dementia subtype compared to the general population where classical Alzheimer's disease predominates...
January 18, 2018: Nephrology
https://www.readbyqxmd.com/read/29334419/a-metallo-pro-drug-to-target-cu-ii-in-the-context-of-alzheimer-s-disease
#12
Amandine Conte-Daban, Vinita Ambike, Régis Guillot, Nicolas Delsuc, Clotilde Policar, Christelle Hureau
Alzheimer's disease and oxidative stress are connected. In the present communication, we report the use of a Mn(II)-based superoxide dismutase mimic ([MnII(L)]+, 1+) as a pro-drug candidate to target Cu(II) associated events, i.e. Cu(II)-induced formation of reactive oxygen species (ROS) and modulation of the amyloid-beta (Abeta) peptide aggregation. Complex 1+ is able to remove Cu(II) from Abeta, stop ROS and prevent alteration of Abeta aggregation as would do the corresponding free ligand LH. Using 1+ instead of LH in further biological applications would have the double advantage to avoid the cell toxicity of LH and to benefit from its proved SOD-like activity...
January 15, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29331080/design-synthesis-and-evaluation-of-novel-oxazaborine-inhibitors-of-the-nlrp3-inflammasome
#13
Alex George Baldwin, Victor S Tapia, Tessa Swanton, Claire S White, James A Beswick, David Brough, Sally Freeman
The NLRP3 inflammasome is an important regulator of the sterile inflammatory response and its activation by host-derived sterile molecules leads to the intracellular activation of caspase-1, processing of the pro-inflammatory cytokines interleukin-1β (IL 1β)/IL-18, and pyroptotic cell death. Inappropriate activation of NLRP3 drives a chronic inflammatory response and is implicated in several non-communicable diseases, including gout, atherosclerosis, type II diabetes and Alzheimer's disease. In this study, we report the design, synthesis and biological evaluation of novel boron compounds (NBCs) as NLRP3 inflammasome inhibitors...
January 13, 2018: ChemMedChem
https://www.readbyqxmd.com/read/29316492/synapse-to-nucleus-communication-from-developmental-disorders-to-alzheimer-s-disease
#14
REVIEW
Elena Marcello, Monica Di Luca, Fabrizio Gardoni
In the last decade several synaptonuclear protein messengers including Jacob, CRTC1, AIDA-1, ProSaP2/Shank3 and RNF10 have been identified and characterized as key players for modulation of synaptic transmission and synaptic plasticity. Activation of excitatory glutamatergic synapses leads to their shuttling from the synapse to the nucleus, mostly importin-mediated, and subsequent regulation of gene transcription needed for long lasting modifications of synaptic function. Accordingly, increasing evidences show that alterations of the activity of synaptonuclear messengers are correlated to synaptic failure as observed in different synaptopathies...
January 6, 2018: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/29305855/microglia-derived-extracellular-vesicles-in-alzheimer-s-disease-a-double-edged-sword
#15
REVIEW
Teresa Trotta, Maria Antonietta Panaro, Antonia Cianciulli, Giorgio Mori, Adriana Di Benedetto, Chiara Porro
Extracellular vesicles (EVs), based on their origin or size, can be classified as apoptotic bodies, microvesicles (MVs)/microparticles (MPs), and exosomes. EVs are one of the new emerging modes of communication between cells that are providing new insights into the pathophysiology of several diseases. EVs released from activated or apoptotic cells contain specific proteins (signaling molecules, receptors, integrins, cytokines), bioactive lipids, nucleic acids (mRNA, miRNA, small non coding RNAs, DNA) from their progenitor cells...
January 3, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29283464/tgf-%C3%AE-2-and-tgf-%C3%AE-3-from-cultured-%C3%AE-amyloid-treated-or-3xtg-ad-derived-astrocytes-may-mediate-astrocyte-neuronal-communication
#16
Laura Tapella, Matteo Cerruti, Isabella Biocotino, Alessio Stevano, Francesca Rocchio, Pier Luigi Canonico, Mariagrazia Grilli, Armando A Genazzani, Dmitry Lim
Astrocytes participate in the development and resolution of neuroinflammation in numerous ways, including the release of cytokines and growth factors. Among many, astrocytes release transforming growth factors beta (TGF-β) TGF-β1, TGF-β2 and TGF-β3. TGF-β1 is the most studied isoform, while production and release of TGF-β2 and 3 by astrocytes has been poorly characterized. Here we report that purified cultures of hippocampal astrocytes produce mainly TGF-β3 followed by TGF-β2 and TGF-β1. Furthermore, astrocytes release principally the active form of TGF-β3 over the other two...
December 28, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29280296/lock-and-chop-a-novel-method-for-the-generation-of-a-pick1-pdz-domain-and-piperidine-based-inhibitor-co-crystal-structure
#17
Douglas J Marcotte, Jean-Christophe Hus, Charles C Banos, Craig Wildes, Robert Arduini, Chris Bergeron, Catherine A Hession, Darren P Baker, Edward Lin, Kevin M Guckian, Anthone W Dunah, Laura F Silvian
The membrane protein interacting with kinase C1 (PICK1) plays a trafficking role in the internalization of neuron receptors such as the amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) receptor. Reduction of surface AMPA type receptors on neurons reduces synaptic communication leading to cognitive impairment in progressive neurodegenerative diseases such as Alzheimer disease. The internalization of AMPA receptors is mediated by the PDZ domain of PICK1 which binds to the GluA2 subunit of AMPA receptors and targets the receptor for internalization through endocytosis, reducing synaptic communication...
December 27, 2017: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/29249935/loss-of-neuroprotective-factors-in-neurodegenerative-dementias-the-end-or-the-starting-point
#18
REVIEW
Luisa Benussi, Giuliano Binetti, Roberta Ghidoni
Recent clinical, genetic and biochemical experimental evidences highlight the existence of common molecular pathways underlying neurodegenerative diseases. In this review, we will explore a key common pathological mechanism, i.e., the loss of neuroprotective factors, across the three major neurodegenerative diseases leading to dementia: Alzheimer's disease (AD), Frontotemporal dementia (FTD) and Lewy body dementia (LBD). We will report evidences that the Brain Derived Neurotrophic Factor (BDNF), the most investigated and characterized brain neurotrophin, progranulin, a multi-functional adipokine with trophic and growth factor properties, and cystatin C, a neuroprotective growth factor, are reduced in AD, FTD, and LBD...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29244125/discourse-features-among-providers-patients-and-companions-and-their-effect-on-outcomes-of-dementia-diagnosis-disclosure
#19
Matthew J Wynn, Brian D Carpenter
Objectives: Receiving a diagnosis of dementia has major implications. Although protocols for disclosing difficult information have been developed for other health conditions, no such evidence-based method exists for dementia. As a step toward that goal, this study analyzed the discourse within dementia diagnosis disclosure sessions to identify conversational features associated with psychological outcomes. Method: The Roter Interaction Analysis System (RIAS) was used to code the discourse among patients, their companions, and providers during 84 dementia diagnosis disclosure sessions following an initial evaluation at an Alzheimer's Disease Research Center...
December 13, 2017: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/29229199/microbiota-and-aging-a-review-and-commentary
#20
REVIEW
Carmen García-Peña, Teresa Álvarez-Cisneros, Ricardo Quiroz-Baez, Robert P Friedland
Although there is a consensus that the dominant species that make up the adult microbiota remains unchanged in elderly people, it has been reported that there are significant alterations in the proportion and composition of the different taxa, leading to reduced microbiota diversity, as well as an increase of enteropathogens that may lead to chronic inflammation. The ageing of mucosal immune and motor systems also contributes to these changes. As the individual ages, there is a loss in the number of Peyer's patches, an altered local capacity of T and B cell functions as well as chronic macrophage activation...
December 8, 2017: Archives of Medical Research
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