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Communication and Alzheimer's disease

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https://www.readbyqxmd.com/read/27910252/memory-performance-on-the-story-recall-test-and-prediction-of-cognitive-dysfunction-progression-in-mild-cognitive-impairment-and-alzheimer-s-dementia
#1
Jong-Hwan Park, Hyuntae Park, Sang Wuk Sohn, Sungjae Kim, Kyung Won Park
AIM: To determine the factors that influence diagnosis and differentiation of patients with mild cognitive impairment (MCI) and Alzheimer's dementia (AD) by comparing memory test results at baseline with those at 1-2-year follow up. METHODS: We consecutively recruited 23 healthy participants, 44 MCI patients and 27 patients with very mild AD according to the National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer's Disease and Related Disorder Association criteria for probable Alzheimer's disease and Petersen's clinical diagnostic criteria...
December 1, 2016: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/27904818/the-government-s-role-in-regulating-coordinating-and-standardizing-the-response-to-alzheimer-s-disease-anticipated-international-cooperation-in-the-area-of-intractable-and-rare-diseases
#2
REVIEW
Qi Tang, Peipei Song, Lingzhong Xu
The World Health Organization (WHO) has emphasized that aging of the population is inextricably linked to many other global public health issues, such as universal health coverage, non-communicable diseases, and disability. However, Alzheimer's Disease International (ADI) estimates that 46.8 million elderly people worldwide were living with dementia in 2015. Alzheimer's disease (AD), the most common form of dementia, is one of the most common neurodegenerative diseases and is the main cause of cognitive impairment...
November 2016: Intractable & Rare Diseases Research
https://www.readbyqxmd.com/read/27903226/protective-effects-of-caffeic-acid-and-the-alzheimer-s-brain-an-update
#3
Solomon Habtemariam
Caffeic acid (CA) and related phenylpropanoic acids are ubiquitous natural products of the shikimic acid pathway origin. Due to the presence of diorthohydroxyl aromatic (catecholic) moiety, CA is not only one of the most potent antioxidant phenyl propanoids but also display numerous other pharmacological effects ranging from antiinflammatory to anticancer effects. Recent studies also demonstrated that CA both in its free form or conjugated with other groups such as quinic acid and sugars display profound effects in the brain including protection from toxicity induced by a variety of agents and/or experimental models of Alzheimer's disease (AD)...
November 29, 2016: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/27846918/neurology-health-advocacy-curriculum-needs-assessment-curricular-content-and-underlying-components
#4
Ahmad Rida Abuzinadah, Lara Cooke
BACKGROUND: Lack of a health advocacy curriculum and clarity are obstacles for effectively teaching neurology health advocacy (NHA) to neurology residents. Our purpose is to assess the need and develop content for a NHA curriculum and to describe its underlying components. METHODS: This is a cross-sectional study with two steps. In step one, neurologists and neurology residents at University of Calgary were surveyed about their perception of teaching NHA and asked to rank 56 neurological diseases on a Likert scale based on how well they lend themselves to teaching health advocacy...
November 16, 2016: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/27845490/cognitive-disability-in-alzheimer-s-disease-and-its-management
#5
M Corsi, T Di Raimo, C Di Lorenzo, M Rapp-Ricciardi, T Archer, S Ricci, R Businaro
Cognitive disability linked to neurodegenerative diseases and in particular to Alzheimer's disease, remains an increasing cause for concern through a dramatic prevalence increment and associated socio-economic burdens. Initially Alzheimer's disease develops asymptomatically with primary clinical signs, such as memory impairment, decline of spatial and perceptual abilities, occurring at a later stage. This delay implies the possibility of promoting early interventions during the pre-symptomatic stage of the disease...
September 2016: La Clinica Terapeutica
https://www.readbyqxmd.com/read/27802513/assessment-of-the-incremental-diagnostic-value-of-florbetapir-f-18-imaging-in-patients-with-cognitive-impairment-the-incremental-diagnostic-value-of-amyloid-pet-with-18f-florbetapir-india-fbp-study
#6
Marina Boccardi, Daniele Altomare, Clarissa Ferrari, Cristina Festari, Ugo Paolo Guerra, Barbara Paghera, Claudio Pizzocaro, Giulia Lussignoli, Cristina Geroldi, Orazio Zanetti, Maria Sofia Cotelli, Marinella Turla, Barbara Borroni, Luca Rozzini, Dario Mirabile, Carlo Defanti, Michele Gennuso, Alessandro Prelle, Simona Gentile, Alessandro Morandi, Stefano Vollaro, Giorgio Dalla Volta, Angelo Bianchetti, Marta Zaffira Conti, Melania Cappuccio, Pasqualina Carbone, Daniele Bellandi, Luciano Abruzzi, Luigi Bettoni, Daniele Villani, Maria Clara Raimondi, Alessia Lanari, Alfonso Ciccone, Emanuela Facchi, Ignazio Di Fazio, Renzo Rozzini, Stefano Boffelli, Laura Manzoni, Giovanni Pietro Salvi, Sabina Cavaliere, Gloria Belotti, Stefano Avanzi, Patrizio Pasqualetti, Cristina Muscio, Alessandro Padovani, Giovanni B Frisoni
Importance: Cerebral amyloidosis is a key abnormality in Alzheimer disease (AD) and can be detected in vivo with positron emission tomography (PET) ligands. Although amyloid PET has clearly demonstrated analytical validity, its clinical utility is debated. Objective: To evaluate the incremental diagnostic value of amyloid PET with florbetapir F 18 in addition to the routine clinical diagnostic assessment of patients evaluated for cognitive impairment. Design, Setting, and Participants: The Incremental Diagnostic Value of Amyloid PET With [18F]-Florbetapir (INDIA-FBP) Study is a multicenter study involving 18 AD evaluation units from eastern Lombardy, Northern Italy, 228 consecutive adults with cognitive impairment were evaluated for AD and other causes of cognitive decline, with a prescan diagnostic confidence of AD between 15% and 85%...
October 31, 2016: JAMA Neurology
https://www.readbyqxmd.com/read/27790089/proteomic-substrate-identification-for-membrane-proteases-in-the-brain
#7
REVIEW
Stephan A Müller, Simone D Scilabra, Stefan F Lichtenthaler
Cell-cell communication in the brain is controlled by multiple mechanisms, including proteolysis. Membrane-bound proteases generate signaling molecules from membrane-bound precursor proteins and control the length and function of cell surface membrane proteins. These proteases belong to different families, including members of the "a disintegrin and metalloprotease" (ADAM), the beta-site amyloid precursor protein cleaving enzymes (BACE), membrane-type matrix metalloproteases (MT-MMP) and rhomboids. Some of these proteases, in particular ADAM10 and BACE1 have been shown to be essential not only for the correct development of the mammalian brain, but also for myelination and maintaining neuronal connections in the adult nervous system...
2016: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/27757204/the-effect-of-green-tea-consumption-on-oxidative-stress-markers-and-cognitive-function-in-patients-with-alzheimer-s-disease-a-prospective-intervention-study
#8
Horrolein Arab, Soleiman Mahjoub, Karimollah Hajian-Tilaki, Mehdi Moghadasi
BACKGROUND: Alzheimer's disease (AD) is the most prevalent degenerative disorder of the brain among elderly individuals. Many studies indicate that oxidative stress is an important pathogenic factor which involves oxidizing macromolecules such as DNA, lipids, and proteins in AD. Green tea is a rich source of antioxidant compounds that can remove radical oxygen species. The purpose of this study was to investigate the influence of green tea consumption on markers of oxidative stress in AD...
2016: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/27733281/global-regional-and-national-life-expectancy-all-cause-mortality-and-cause-specific-mortality-for-249-causes-of-death-1980-2015-a-systematic-analysis-for-the-global-burden-of-disease-study-2015
#9
COMMENT
(no author information available yet)
BACKGROUND: Improving survival and extending the longevity of life for all populations requires timely, robust evidence on local mortality levels and trends. The Global Burden of Disease 2015 Study (GBD 2015) provides a comprehensive assessment of all-cause and cause-specific mortality for 249 causes in 195 countries and territories from 1980 to 2015. These results informed an in-depth investigation of observed and expected mortality patterns based on sociodemographic measures. METHODS: We estimated all-cause mortality by age, sex, geography, and year using an improved analytical approach originally developed for GBD 2013 and GBD 2010...
October 8, 2016: Lancet
https://www.readbyqxmd.com/read/27725817/bacteroides-fragilis-lipopolysaccharide-and-inflammatory-signaling-in-alzheimer-s-disease
#10
Walter J Lukiw
The human microbiome consists of ~3.8 × 10(13) symbiotic microorganisms that form a highly complex and dynamic ecosystem: the gastrointestinal (GI) tract constitutes the largest repository of the human microbiome by far, and its impact on human neurological health and disease is becoming increasingly appreciated. Bacteroidetes, the largest phylum of Gram-negative bacteria in the GI tract microbiome, while generally beneficial to the host when confined to the GI tract, have potential to secrete a remarkably complex array of pro-inflammatory neurotoxins that include surface lipopolysaccharides (LPSs) and toxic proteolytic peptides...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27712050/human-dopamine-receptor-conjugated-multidimensional-conducting-polymer-nanofiber-membrane-for-dopamine-detection
#11
Seon Joo Park, Seung Hwan Lee, Heehong Yang, Chul Soon Park, Chang-Soo Lee, Oh Seok Kwon, Tai Hyun Park, Jyongsik Jang
In the brain and central nervous system, dopamine plays a crucial function as a neurotransmitter or a local chemical messenger for interneuronal communication. Dopamine is associated with renal, hormonal, and cardiovascular systems. Additionally, dopamine dysfunction is known to cause serious illnesses, such as Parkinson's disease and Alzheimer's disease. Therefore, dopamine detection is essential for medical diagnosis and disease prevention, which require a novel strategy with high sensitivity and selectivity, and with a rapid response...
October 7, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27698682/microwaves-and-alzheimer-s-disease
#12
Xia Zhang, Wen-Juan Huang, Wei-Wei Chen
Alzheimer's diseases (AD) is the most common type of dementia and a neurodegenerative disease that occurs when the nerve cells in the brain die. The cause and treatment of AD remain unknown. However, AD is a disease that affects the brain, an organ that controls behavior. Accordingly, anything that can interact with the brain may affect this organ positively or negatively, thereby protecting or encouraging AD. In this regard, modern life encompasses microwaves for all issues including industrial, communications, medical and domestic tenders, and among all applications, the cell phone wave, which directly exposes the brain, continues to be the most used...
October 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27676707/stimulating-access-to-words-in-patients-with-alzheimer-s-disease
#13
Marion Castera, Véronique Kuhn, Franck Medina
OBJECTIVE: Anomia is the second most common disorder after episodic memory loss in patients with Alzheimer's disease. Our objective was to develop a speech therapy protocol for patients with Alzheimer's disease (Mini-Mental State Examination or MMSE≥15) and suffering from a lack of words, in order to improve access to words. MATERIAL/PATIENTS AND METHODS: We stimulated the three stages in the men: - stimulation of lexical selection involved working on the multiple meanings of a word, searching for the relevant and specific features of a word in order to make a guess, and bringing to mind a target word from specific features; - stimulation of morphological encoding involved extracting the meaning of a morpheme by comparing two words, one of which is derived from the other, and then identifying the meaning of an affix by slipping it into a sentence; - phonological encoding was stimulated by the isolation of the initial two-syllable words and merging them to form a third word...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27662312/stress-induced-synaptic-dysfunction-and%C3%A2-neurotransmitter-release-in%C3%A2-alzheimer-s-disease-can-neurotransmitters-and-neuromodulators-be%C3%A2-potential-therapeutic-targets
#14
Saurabh Kumar Jha, Niraj Kumar Jha, Dhiraj Kumar, Renu Sharma, Abhishek Shrivastava, Rashmi K Ambasta, Pravir Kumar
The communication between neurons at synaptic junctions is an intriguing process that monitors the transmission of various electro-chemical signals in the central nervous system. Albeit any aberration in the mechanisms associated with transmission of these signals leads to loss of synaptic contacts in both the neocortex and hippocampus thereby causing insidious cognitive decline and memory dysfunction. Compelling evidence suggests that soluble amyloid-β (Aβ) and hyperphosphorylated tau serve as toxins in the dysfunction of synaptic plasticity and aberrant neurotransmitter (NT) release at synapses consequently causing a cognitive decline in Alzheimer's disease (AD)...
September 23, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27659705/the-role-of-extracellular-vesicles-in-neurodegenerative-diseases
#15
Camelia Quek, Andrew F Hill
Extracellular vesicles, including exosomes, are small membranous vesicles released from many biotypes, contributing to the disease progression and spreading. These extracellular vesicles provide an important mode of cell-to-cell communication by delivering proteins, lipids and RNA to target cells. Exosomes are found associated with neurodegenerative diseases, which are characterised by progressive degeneration of neurons and often associated with misfolded protein. The common diseases include Parkinson's disease (PD), Alzheimer's diseases (AD), amyotrophic lateral sclerosis (ALS), and the prion diseases...
September 19, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27651259/the-advances-in-neurobiology
#16
M Ishwarya, R T Narendhirakannan
Neurological disorders are diseases of the brain, the spine, and the nerves that connect them. There are more than 600 diseases of the nervous system, such as brain tumors, epilepsy, Parkinson's disease, and stroke as well as less familiar ones such as frontotemporal dementia, Alzheimer's disease, and other dementias; cerebrovascular diseases including stroke, migraine, and other headache disorders; multiple sclerosis; neuroinfections; brain tumors; traumatic disorders of the nervous system such as brain trauma; and neurological disorders as a result of malnutrition...
2016: Advances in Neurobiology
https://www.readbyqxmd.com/read/27650313/the-nlrp3-inflammasome-in-pathogenic-particle-and-fibre-associated-lung-inflammation-and-diseases
#17
REVIEW
Mutlay Sayan, Brooke T Mossman
The concept of the inflammasome, a macromolecular complex sensing cell stress or danger signals and initiating inflammation, was first introduced approximately a decade ago. Priming and activation of these intracellular protein platforms trigger the maturation of pro-inflammatory chemokines and cytokines, most notably, interleukin-1β (IL-1β) and IL-18, to promulgate innate immune defenses. Although classically studied in models of gout, Type II diabetes, Alzheimer's disease, and multiple sclerosis, the importance and mechanisms of action of inflammasome priming and activation have recently been elucidated in cells of the respiratory tract where they modulate the responses to a number of inhaled pathogenic particles and fibres...
September 20, 2016: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/27636845/the-effects-of-an-apoe-promoter-polymorphism-on-human-white-matter-connectivity-during-non-demented-aging
#18
Peifen Chang, Xin Li, Chao Ma, Sisi Zhang, Zhen Liu, Kewei Chen, Lin Ai, Jingling Chang, Zhanjun Zhang
Polymorphisms of the apolipoprotein E (APOE) promoter rs405509 are related to Alzheimer's disease (AD). The T/T allele of rs405509 decreases the transcription of the APOE gene and leads to impairments in a specific brain structural network in aged individuals; thus, it is an important risk factor for AD. However, it remains unknown whether rs405509 affects white matter networks during aging. Here, we investigated the effect of the rs405509 genotype (T/T versus G-allele) on age-related brain white matter structural networks via construction of the graph theory-based structural connectome using diffusion MRI data in a large cohort...
September 13, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27636840/increased-levels-of-extracellular-microvesicle-markers-and-decreased-levels-of-endocytic-exocytic-proteins-in-the-alzheimer-s-disease-brain
#19
Sravani Musunuri, Payam Emami Khoonsari, Maria Mikus, Magnus Wetterhall, Anna Häggmark-Mänberg, Lars Lannfelt, Anna Erlandsson, Jonas Bergquist, Martin Ingelsson, Ganna Shevchenko, Peter Nilsson, Kim Kultima
BACKGROUND: Alzheimer's disease (AD) is a chronic neurodegenerative disorder accounting for more than 50% of all dementia cases. AD neuropathology is characterized by the formation of extracellular plaques and intracellular neurofibrillary tangles consisting of aggregated amyloid-β and tau, respectively. The disease mechanism has only been partially elucidated and is believed to also involve many other proteins. OBJECTIVE: This study intended to perform a proteomic profiling of post mortem AD brains and compare it with control brains as well as brains from other neurological diseases to gain insight into the disease pathology...
October 18, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27633250/positron-emission-tomography-measurement-of-brain-mao-b-inhibition-in-patients-with-alzheimer-s-disease-and-elderly-controls-after-oral-administration-of-sembragiline
#20
Stefan Sturm, Anton Forsberg, Stephane Nave, Per Stenkrona, Nicholas Seneca, Andrea Varrone, Robert A Comley, Patrik Fazio, Candice Jamois, Ryuji Nakao, Zbigniew Ejduk, Nabil Al-Tawil, Ulrika Akenine, Christer Halldin, Niels Andreasen, Benedicte Ricci
PURPOSE: In Alzheimer's disease (AD), increased metabolism of monoamines by monoamine oxidase type B (MAO-B) leads to the production of toxic reactive oxygen species (ROS), which are thought to contribute to disease pathogenesis. Inhibition of the MAO-B enzyme may restore brain levels of monoaminergic neurotransmitters, reduce the formation of toxic ROS and reduce neuroinflammation (reactive astrocytosis), potentially leading to neuroprotection. Sembragiline (also referred as RO4602522, RG1577 and EVT 302 in previous communications) is a potent, selective and reversible inhibitor of MAO-B developed as a potential treatment for AD...
September 16, 2016: European Journal of Nuclear Medicine and Molecular Imaging
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