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https://www.readbyqxmd.com/read/28726510/the-effect-of-probiotic-lactobacillus-casei-shirota-on-knee-osteoarthritis-a-randomised-double-blind-placebo-controlled-clinical-trial
#1
M Lei, C Guo, D Wang, C Zhang, L Hua
Knee osteoarthritis (OA) treatment is challenging due to inefficacy and adverse effects of current medications. Probiotic treatment has been shown to promote bone metabolism, reduce pain and inflammatory responses of age-related musculoskeletal disorders, including OA. We aimed to investigate the effect of probiotic Lactobacillus casei Shirota (LcS) on patients with knee OA. 537 patients with knee OA were enrolled in this double-blind, placebo-controlled trial, who were randomised to receive skimmed milk containing either LcS or placebo daily for 6 months...
July 20, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/28725304/high-c-reactive-protein-and-low-albumin-levels-predict-high-30-day-mortality-in-patients-undergoing-percutaneous-endoscopic-gastrotomy
#2
Omer Karasahin, Pinar Tosun Tasar, Ozge Timur, Dogan Nasir Binici, Tugba Kiper Yilmaz, Adem Aslan, Sevnaz Sahin
BACKGROUND: Percutaneous endoscopic gastrotomy (PEG) enables long-term enteral feeding. The aim of this study was to identify biomarkers that may guide the decision of whether to perform the elective procedure of PEG. METHODS: The medical records of all patients who underwent PEG in our hospital from 2010 to 2016 were screened retrospectively. Patients with mortality within a 30-day follow-up period and those without were compared using the Chi-square test, and continuous variables were compared with the Kruskal-Wallis and Mann-Whitney U tests...
June 2017: Gastroenterology Research
https://www.readbyqxmd.com/read/28724846/metabolic-and-inflammatory-changes-with-orlistat-and-sibutramine-treatment-in-obese-malaysian-subjects
#3
Belqes Abdullah Mohammad Al-Tahami, Ab Aziz Al-Safi Ismail, Zulkefli Sanip, Zurkurnai Yusoff, Tg Muzaffar Tm Shihabudin, Taran Singh Pall Singh, Aida Hanum Ghulam Rasool
INTRODUCTION: Obesity is associated with numerous health problems, particularly metabolic and cardiovascular complications. This study aimed to assess the effects that, nine months of pharmacological intervention with orlistat or sibutramine, on obese Malaysians' body weight and compositions, metabolic profiles and inflammatory marker. METHODS: Seventy-six obese subjects were randomly placed into two groups. The first group received three daily 120 mg dosages of orlistat for nine months (n=39), and the second group received a once daily 10 or 15 mg dosage of sibutramine for nine months (n=37)...
2017: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/28724840/exposure-to-parental-smoking-in-childhood-is-associated-with-high-c-reactive-protein-in-adulthood-the-cardiovascular-risk-in-young-finns-study
#4
Di Wang, Markus Juonala, Jorma S A Viikari, Feitong Wu, Nina Hutri-Kähönen, Olli T Raitakari, Costan G Magnussen
AIM: Children exposed to parental smoking are at increased long-term risk of subclinical atherosclerosis in adulthood. However, it has not been quantified if exposure to parental smoking in childhood is associated with adult systemic inflammation. This study aimed to determine if childhood exposure to parental smoking was associated with high-sensitivity C-reactive protein (hsCRP) in adulthood. METHODS: This longitudinal analysis of 2,511 participants used data from the Cardiovascular Risk in Young Finns Study, a prospective cohort of Finnish children...
July 20, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28721654/c-reactive-protein-gene-contributes-to-the-genetic-susceptibility-of-hemorrhagic-stroke-in-men-a-case-control-study-in-chinese-han-population
#5
Yong Xue, Long Zhang, Yao Fan, Qianhui Li, Yuzhang Jiang, Chong Shen
High-sensitivity C-reactive protein (hsCRP) is an inflammatory marker for the prediction and prognosis of ischemic stroke but there is an absence of evidence for cerebral hemorrhagic events. The aim of this study is to investigate the effects of elevated plasma hsCRP and CRP genetic variants on hemorrhagic stroke (HS). Two hundred thirty-six inpatients with HS and 993 age-matched controls from a community-based population were included in a case-control study and four tagging single nucleotide polymorphsims (tagSNPs) at CRP were genotyped...
July 18, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28721153/fibroblast-growth-factor-23-iron-and-inflammation-are-they-related-in-early-stages-of-chronic-kidney-disease
#6
Ewelina Lukaszyk, Mateusz Lukaszyk, Ewa Koc-Zorawska, Anna Bodzenta-Lukaszyk, Jolanta Malyszko
INTRODUCTION: Fibroblast growth factor 23 (FGF-23) levels are elevated in impaired renal function. Inflammation and iron are potential regulators of FGF-23. The aim of the study was to evaluate the association between FGF-23 concentration, novel iron status biomarkers and inflammatory parameters among patients with early stages of chronic kidney disease (CKD). MATERIAL AND METHODS: The study population included 84 patients with CKD in the early stage. Serum hemoglobin, fibrinogen, creatinine, iron, transferrin saturation and ferritin levels were measured using standard laboratory methods...
June 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28721148/association-of-moderate-aerobic-exercise-and-rho-associated-kinase-2-concentration-in-subjects-with-dyslipidemia
#7
Huadong Bai, Jingchun Sun, Guiying Du, Fengjun Jiao
INTRODUCTION: Dyslipidemia is associated with increased rho-associated kinase 2 (ROCK2) concentration. Whether moderate aerobic exercise could attenuate leukocyte ROCK2 concentration is unknown. MATERIAL AND METHODS: One hundred subjects with dyslipidemia and without statin treatment were enrolled and assigned to exercise and control groups. In the exercise group, at least 30 min of moderate aerobic exercise per day 5 times weekly was recommended. In the control group, participants were recommended to undertake exercise of the same intensity as the exercise group but not mandatorily...
June 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28721139/vitamin-d-deficiency-and-non-lipid-biomarkers-of-cardiovascular-risk
#8
Kamil F Faridi, Joshua R Lupton, Seth S Martin, Maciej Banach, Renato Quispe, Krishnaji Kulkarni, Steven R Jones, Erin D Michos
INTRODUCTION: Deficient 25-hydroxyvitamin D (25(OH)D) levels have been associated with dyslipidemia and cardiovascular diseases, though the underlying mechanism of these associations is uncertain. We analyzed associations between vitamin D and other non-lipid biomarkers of cardiovascular risk to better elucidate possible relationships between deficient 25(OH)D and cardiovascular disease. MATERIAL AND METHODS: We performed a cross-sectional analysis of 4,591 adults included in a clinical laboratory database from 2009 to 2011 with available measurements for 25(OH)D and the following biomarkers: homocysteine (Hcy), high-sensitivity C-reactive protein (hs-CRP), cystatin-C, creatinine, γ-glutamyltransferase (GGT), uric acid, and hemoglobin A1c (HbA1c)...
June 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28719789/waist-to-height-ratio-in-indian-women-comparison-with-traditional-indices-of-obesity-association-with-inflammatory-biomarkers-and-lipid-profile
#9
Sharvari Dilip Malshe, Shobha Anand Udipi
We compared waist-to-height ratio (WHtR) with traditional anthropometric indices in healthy women aged 21 to 45 years from urban slums of Mumbai city, India. Lipid profile and inflammatory markers were measured in a subsample of 200 women, and their relationship with WHtR was examined. Mean WHtR was 0.50 ± 0.1, but a little more than half (51.9%) of the women had WHtR ≥0.50. WHtR could correctly identify centrally obese adult women, even when they were categorized as healthy or normal according to body mass index, waist circumference, waist to hip ratio, and percentage body fat...
July 2017: Asia-Pacific Journal of Public Health
https://www.readbyqxmd.com/read/28719765/beetroot-juice-is-more-beneficial-than-sodium-nitrate-for-attenuating-muscle-pain-after-strenuous-eccentric-bias-exercise
#10
Tom Clifford, Glyn Howatson, Daniel J West, Emma J Stevenson
The aim of this study was to compare the effects of beetroot juice (BTJ) and a nitrate only drink (sodium nitrate; SN) on indices of exercise-induced muscle damage (EIMD). Thirty recreationally active males consumed either BTJ (n=10), a nitrate matched SN drink (n=10) or an isocaloric placebo (PLA; n=10) immediately, 24 and 48 h after performing 100 drop jumps. To assess muscle damage, maximal isometric voluntary contractions (MIVC), countermovement jumps (CMJ), pressure-pain threshold (PPT), creatine kinase (CK) and high sensitivity C-reactive protein (hs-CRP) were measured pre, immediately post, 24, 48 and 72 h following the drop jumps...
July 18, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28716357/clinical-and-metabolic-response-to-flaxseed-oil-omega-3-fatty-acids-supplementation-in-patients-with-diabetic-foot-ulcer-a-randomized-double-blind-placebo-controlled-trial
#11
Zahra Soleimani, Fatemeh Hashemdokht, Fereshteh Bahmani, Mohsen Taghizadeh, Mohammad Reza Memarzadeh, Zatollah Asemi
BACKGROUND: Data on the effects of flaxseed oil omega-3 fatty acids supplementation on wound healing and metabolic status in subjects with diabetic foot ulcer (DFU) are scarce. OBJECTIVE: This study was conducted to evaluate the effects of flaxseed oil omega-3 fatty acids supplementation on wound healing and metabolic status in subjects with DFU. METHODS: The current randomized, double-blind, placebo-controlled trial was conducted among 60 subjects (aged 40-85years old) with grade 3 DFU...
June 28, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28715069/impact-of-diabetes-on-association-between-epicardial-fat-thickness-and-extent-and-complexity-of-coronary-artery-disease-in-patients-with-non-st-elevation-myocardial-infarction
#12
Taner Seker, Caner Turkoglu, Hazar Harbalıoglu, Mustafa Gur
BACKGROUND: Epicardial fat thickness (EFT) is associated with increased cardio metabolic risk. Recent studies have suggested that there is a strong relationship between diabetes and EFT. Although the relationship between EFT and coronary artery disease (CAD) is well known, the possible impact of diabetes on the relationship between EFT and extent and complexity of CAD was not fully investigated. AIM: We aimed to investigate the relationship between EFT and extent and complexity of CAD in patients with non-ST elevation myocardial infarction (NSTEMI) with and without diabetes...
July 17, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28714526/different-postconditioning-cycles-affect-prognosis-of-aged-patients-undergoing-primary-percutaneous-coronary-intervention
#13
Jie Zhang, Xin Zhang, Yuqi Cui, Misbahul Ferdous, Lianqun Cui, Peng Zhao
BACKGROUND: Postconditioning can affect the infarct size in acute myocardial infarction (AMI). However, few studies show an effect of different postconditioning cycles on AMI aged patients. This study sought to assess the effect of different postconditioning cycles on prognosis in aged patients with AMI who underwent primary percutaneous coronary intervention (PCI). METHODS: 74 aged patients were randomly assigned to three groups. Control group; PC-1 group accepted postconditioning 4 cycles of 30 s inflation and 30 s deflation; PC-2 group accepted postconditioning 4 cycles of 60 s...
July 17, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28714287/bacteremia-prediction-model-for-community-acquired-pneumonia-external-validation-in-a-multicenter-retrospective-cohort
#14
Byunghyun Kim, Jungho Choi, Kyuseok Kim, Sujin Jang, Tae Gun Shin, Won Young Kim, Jung-Youn Kim, Yoo Seok Park, Soo Hyun Kim, Hui Jai Lee, Jonghwan Shin, JeSung You, Kyung Su Kim, Sung Phil Chung
OBJECTIVE: Many studies have described constructing a prediction model for bacteremia in community-acquired pneumonia (CAP), but these studies were not validated in external heterogeneous groups. The objective of this study was to test the generalizability of a previous bacteremia prediction model for CAP by external validation. METHODS: This multicenter retrospective cohort analysis was performed in eight tertiary urban hospital emergency departments (ED). We reviewed adult patients who were hospitalized after presentation to the ED with CAP...
July 16, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28713837/the-predictive-role-of-tooth-extractions-oral-infections-and-hs-c-reactive-protein-for-mortality-in-individuals-with-and-without-diabetes-a-prospective-cohort-study-of-a-12-1-2-year-follow-up
#15
Lise Lund Håheim, Kjersti S Rønningen, Morten Enersen, Ingar Olsen
The predictive role of high-sensitivity C-reactive protein (hs-CRP), number of tooth extractions, and oral infections for mortality in people with and without diabetes is unclear. This prospective cohort study is a 12 1/2-year follow-up of the Oslo II study, a health survey in 2000. In all, 12,764 men were invited. Health information was retrieved from 6434 elderly men through questionnaire information, serum measurements, and anthropometric and blood pressure measurements. Diabetes was reported by 425 men...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28711272/the-infection-of-mycoplasma-hominis-after-total-knee-replacement-case-report-and-literature-review
#16
Hong-Jiu Qiu, Wei-Ping Lu, Min Li, Zi-Ming Wang, Quan-Yin Du, Ai-Min Wang, Yan Xiong
The Mycoplasma hominis infection is a rare postoperative complication after joint replacement. Based on our knowledge, there were only two cases reported by Korea all over the world currently. A case of postoperative Mycoplasma hominis infection after total knee replacement in our hospital was reported in this article. It was confirmed through mass spectrometer and Mycoplasma cultivation and treated by the first stage debridement, polyethylene insert replacement, and then drainage and irrigation combined with sensitive antibiotics after the operation...
June 22, 2017: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/28705785/determination-of-certain-bacterial-groups-in-gut-microbiota-and-endotoxin-levels-in-patients-with-nonalcoholic-steatohepatitis
#17
Ceren Özkul, Meltem Yalınay, Tarkan Karakan, Güldal Yılmaz
BACKGROUND/AIMS: In recent years, the role of the gut microbiota has emerged in several diseases. Herein we aimed to determine the fecal microbiota, endotoxin levels, and inflammation markers in patients with nonalcoholic steatohepatitis (NASH) and healthy controls. MATERIALS AND METHODS: A total of 46 NASH patients and 38 healthy controls were included. NASH patients were diagnosed according to the steatosis, activity, and fibrosis score/fatty liver inhibition of progression algorithm...
July 13, 2017: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/28705458/insulin-resistance-and-elevated-c-reactive-protein-among-first-degree-relatives-of-ischemic-stroke-patients
#18
Krishnamoorthy Srilatha, Zachariah Bobby, D K Subrahmanyam, Uppoor NithinKumar
BACKGROUND: Family history is one of the non-modifiable risk factors for ischemic stroke. Atherosclerosis and thrombosis are the two major mechanisms for cardiovascular disease and stroke. Screening of family members is an important method to identify individuals at risk. Therefore, this study was planned to assess the atherosclerotic risk factors in first-degree relatives of patients with ischemic stroke. METHODOLOGY: Case group included 40 first-degree relatives of ischemic stroke patients between 30 and 50 years of age...
July 4, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28705080/the-prevalence-of-zinc-deficiency-and-its-correlation-with-iron-status-and-economical-living-area-in-9-12-year-old-children
#19
Tirang R Neyestani, Bahareh Nikooyeh, Majid Hajifaraji, Ali Kalayi
OBJECTIVE: This study aimed firstly to assess zinc and iron status of 9-12-year-old children of Tehran and secondly to determine a cut-off for circulating biomarkers of iron status to identify children at increased risk of zinc deficiency. RESEARCH METHODS & PROCEDURES: In a cross-sectional study, demographic and anthropometric data from 505 boys and 467 girls aged 9-12 years from Tehran primary schools were obtained and their zinc and iron status was assessed. RESULTS: The prevalence of zinc deficiency, anemia, and iron depletion was 12...
July 14, 2017: International Journal for Vitamin and Nutrition Research. Journal International de Vitaminologie et de Nutrition
https://www.readbyqxmd.com/read/28704820/%C3%AE-carotene-concentration-and-its-association-with-inflammatory-biomarkers-in-spanish-schoolchildren
#20
Elena Rodríguez-Rodríguez, Ana M López-Sobaler, Beatriz Navia, Pedro Andrés, Ana I Jiménez-Ortega, Rosa M Ortega
AIM: To examine the correlation between inflammatory biomarkers and plasma β-carotene levels in children. METHODS: A total of 564 Spanish schoolchildren aged 9-12 were observed and studied. Plasma β-carotene levels were assessed by HPLC. A β-carotene level <4.83 µg/dL (0.09 µmol/L) was considered deficient. Plasma tumour necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were measured by immunoenzyme assays. Serum high-sensitivity C-reactive protein (hs-CRP) was tested by immunonephelometry...
July 14, 2017: Annals of Nutrition & Metabolism
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