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high sensitivity c-reactive protein

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https://www.readbyqxmd.com/read/29475212/the-effects-of-vitamin-d-supplementation-on-biomarkers-of-inflammation-and-oxidative-stress-among-women-with-polycystic-ovary-syndrome-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#1
Maryam Akbari, Vahidreza Ostadmohammadi, Kamran B Lankarani, Reza Tabrizi, Fariba Kolahdooz, Seyed Taghi Heydari, Seyed Habibollah Kavari, Naghmeh Mirhosseini, Alireza Mafi, Majid Dastorani, Zatollah Asemi
The current systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to summarize the effect of vitamin D supplementation on biomarkers of inflammation and oxidative stress among women with polycystic ovary syndrome (PCOS). Cochrane library, Embase, PubMed, and Web of Science database were searched to identify related randomized-controlled articles (RCTs) published up to November 2017. Two researchers assessed study eligibility, extracted data, and evaluated risk of bias of included RCTs, independently...
February 23, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29471285/effects-of-docosahexanoic-acid-supplementation-on-inflammatory-and-subcutaneous-adipose-tissue-gene-expression-in-hiv-infected-patients-on-combination-antiretroviral-therapy-cart-a-sub-study-of-a-randomized-double-blind-placebo-controlled-study
#2
Pere Domingo, José Miguel Gallego-Escuredo, Irene Fernández, Joan Villarroya, Ferran Torres, María Del Mar Gutierrez, María Gracia Mateo, Francesc Villarroya, Francesc Vidal, Marta Giralt, Joan Carles Domingo
BACKGROUND: Omega-3 fatty acids have the potential to decrease inflammation and modify gene transcription. Whether docosahexanoic acid (DHA) supplementation can modify systemic inflammatory and subcutaneous adipose tissue (SAT) gene expression in HIV-infected patients is unknown. METHODS: A randomized, double-blind, placebo-controlled trial that enrolled 84 antiretroviral-treated patients who had fasting TG levels from 2.26 to 5.65 mmol/l and received DHA or placebo for 48 weeks was performed (ClinicalTrials...
February 19, 2018: Cytokine
https://www.readbyqxmd.com/read/29471252/relationship-between-monocytes-to-lymphocytes-ratio-and-axial-spondyloarthritis
#3
Yukai Huang, Weiming Deng, Shaoling Zheng, Fan Feng, Zhixiang Huang, Qidang Huang, Xin Guo, Zhengping Huang, Xuechang Huang, Xia Pan, Tianwang Li
BACKGROUND: Axial spondyloarthritis (axSpA) is a progressive, chronic, inflammatory skeletal disorder affecting the spine and sacroiliac joints. Many studies have shown that neutrophils, lymphocytes, monocytes, platelets, and red blood cells (RBCs) play important roles in the inflammatory process of axSpA. Neutrophils to lymphocytes ratio (NLR) and red blood cell distribution width (RDW) have been reported to be simple and inexpensive markers to indicate the disease activity of axSpA...
February 19, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29470975/high-throughput-screening-of-t7-phage-display-and-protein-microarrays-as-a-methodological-approach-for-the-identification-of-ige-reactive-components
#4
P San Segundo-Acosta, M Garranzo-Asensio, C Oeo-Santos, A Montero-Calle, J Quiralte, J Cuesta-Herranz, M Villalba, R Barderas
Olive pollen and yellow mustard seeds are major allergenic sources with high clinical relevance. To aid with the identification of IgE-reactive components, the development of sensitive methodological approaches is required. Here, we have combined T7 phage display and protein microarrays for the identification of allergenic peptides and mimotopes from olive pollen and mustard seeds. The identification of these allergenic sequences involved the construction and biopanning of T7 phage display libraries of mustard seeds and olive pollen using sera from allergic patients to both biological sources together with the construction of phage microarrays printed with 1536 monoclonal phages from the third/four rounds of biopanning...
February 19, 2018: Journal of Immunological Methods
https://www.readbyqxmd.com/read/29470797/body-mass-index-is-independently-associated-with-xanthine-oxidase-activity-in-overweight-obese-population
#5
Aleksandra Klisic, Gordana Kocic, Nebojsa Kavaric, Milovan Jovanovic, Verica Stanisic, Ana Ninic
PURPOSE: The pathophysiological mechanism of the relationship between xanthine oxidase (XO) activity and obesity has not been completely elucidated. Since inflammation and oxidative stress are regarded as key determinants of enlarged adipose tissue, we aimed to investigate the association between oxidative stress (as measured with XO activity), inflammation [as measured with high-sensitivity C-reactive protein (hsCRP)] and obesity [as measured with body mass index (BMI)]. In addition, we wanted to examine whether hsCRP itself plays an independent role in XO activity increase or it is only mediated through obesity...
February 22, 2018: Eating and Weight Disorders: EWD
https://www.readbyqxmd.com/read/29468986/increased-endothelial-dysfunction-and-insulin-resistance-in-patients-with-klinefelter-syndrome
#6
Cem Haymana, Aydogan Aydogdu, Ibrahim Demirci, Mustafa Dinc, Orhan Demir, Deniz Torun, Fatih Yesildal, Coskun Meric, Yalcın Basaran, Alper Sonmez, Omer Azal
Patients with Klinefelter Syndrome (KS) have increased cardiometabolic risk however the pathogenesis is not clear. We investigated the presence of endothelial dysfunction, insulin resistance and inflammation in an unconfounded population of KS. A total of 32 patients with KS (mean age 21.59 ± 1.66 years) and 33 healthy control subjects (mean age: 22.15 ± 1.03 years) were enrolled. The demographic parameters, Asymmetric dimethylarginine (ADMA), homeostatic model assessment of insulin resistance (HOMA-IR) index and high-sensitivity C-reactive protein (hs-CRP) levels were measured...
February 19, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29468764/blood-pressure-lowering-and-anti-inflammatory-effects-of-hesperidin-in-type-2-diabetes-a-randomized-double-blind-controlled-clinical-trial
#7
Fatemeh Homayouni, Fatemeh Haidari, Mehdi Hedayati, Mehrnoosh Zakerkish, Kambiz Ahmadi
Elevated levels of reactive oxygen species under diabetic condition lead to vascular complications and inflammation. This study aimed to examine the effects of hesperidin supplement on blood pressure and inflammatory markers in type 2 diabetes. In this research, 64 patients were randomly allocated to receive 500 mg/day hesperidin or placebo capsules for 6 weeks. Data on systolic blood pressure (SBP), diastolic blood pressure, serum total antioxidant capacity (TAC), tumor necrosis factor alpha, interleukin 6 (IL-6), and high-sensitivity C-reactive protein (hs-CRP) were collected at the baseline and at the end of the study...
February 22, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29468073/survival-prediction-in-mesothelioma-using-a-scalable-lasso-regression-model-instructions-for-use-and-initial-performance-using-clinical-predictors
#8
Andrew C Kidd, Michael McGettrick, Selina Tsim, Daniel L Halligan, Max Bylesjo, Kevin G Blyth
Introduction: Accurate prognostication is difficult in malignant pleural mesothelioma (MPM). We developed a set of robust computational models to quantify the prognostic value of routinely available clinical data, which form the basis of published MPM prognostic models. Methods: Data regarding 269 patients with MPM were allocated to balanced training (n=169) and validation sets (n=100). Prognostic signatures (minimal length best performing multivariate trained models) were generated by least absolute shrinkage and selection operator regression for overall survival (OS), OS <6 months and OS <12 months...
2018: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29466985/association-between-plasma-fatty-acids-and-inflammatory-markers-in-patients-with-and-without-insulin-resistance-and-in-secondary-prevention-of-cardiovascular-disease-a-cross-sectional-study
#9
Ângela Cristine Bersch-Ferreira, Geni Rodrigues Sampaio, Marcella Omena Gehringer, Elizabeth Aparecida Ferraz da Silva Torres, Maria Beatriz Ross-Fernandes, Jacqueline Tereza da Silva, Camila Ragne Torreglosa, Cristiane Kovacs, Renata Alves, Carlos Daniel Magnoni, Bernardete Weber, Marcelo Macedo Rogero
BACKGROUND: Proinflammatory biomarkers levels are increased among patients with cardiovascular disease, and it is known that both the presence of insulin resistance and diet may influence those levels. However, these associations are not well studied among patients with established cardiovascular disease. Our objective is to compare inflammatory biomarker levels among cardiovascular disease secondary prevention patients with and without insulin resistance, and to evaluate if there is any association between plasma fatty acid levels and inflammatory biomarker levels among them...
February 21, 2018: Nutrition Journal
https://www.readbyqxmd.com/read/29466947/stroke-as-an-atypical-initial-presentation-of-giant-cell-arteritis
#10
Tharsika Kuganesan, Allen R Huang
BACKGROUND: Giant cell arteritis (GCA) is an immune mediated inflammatory disease of medium and large arteries which afflicts older people. The classical presentation features include: headache, visual disturbances, and jaw claudication. Patients diagnosed with GCA have also been observed to be at higher risk for the subsequent development of strokes. CASE PRESENTATION: We describe a case of an 84-year old right-handed man who presented to hospital with dysarthria, dysphagia, right-sided facial drop, a history of generalized weakness and multiple falls...
February 21, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29466786/long-term-vitamin-d-supplementation-and-the-effects-on-recurrence-and-metabolic-status-of-cervical-intraepithelial-neoplasia-grade-2-or-3-a-randomized-double-blind-placebo-controlled-trial
#11
Zahra Vahedpoor, Samaneh Mahmoodi, Mansooreh Samimi, Hamid Reza Gilasi, Fereshteh Bahmani, Ali Soltani, Mehran Sharifi Esfahani, Zatollah Asemi
OBJECTIVE: This study was conducted to evaluate the effects of vitamin D supplementation on the recurrence and metabolic status of patients with cervical intraepithelial neoplasia grade 2 or 3 (CIN2/3). METHODS: This randomized, double-blind, placebo-controlled trial was carried out among 58 women diagnosed with CIN2/3. Participants were randomly assigned into 2 groups to receive either 50,000 IU vitamin D3 (n = 29) or placebo (n = 29) every 2 weeks for 6 months...
February 21, 2018: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/29466167/-lung-hyperinflation-in-chronic-obstructive-pulmonary-disease-and-long-term-outcomes-of-percutaneous-coronary-intervention
#12
V K Zafiraki, E D Kosmachyeva, L V Shulzhenko, D M Ramazanov, A A Omarov, I V Pershukov
OBJECTIVE: to assess the effect of lung hyperinflation (LHI) in patients with chronic obstructive pulmonary disease (COPD) on longterm outcomes of percutaneous coronary intervention (PCI). MATERIALS AND METHODS: Patients with COPD who suffered stable ischemic heart disease and underwent PCI (n=135) were included in a prospective cohort study. LHI was found in 60 patients, while 75 patients had no LHI. Evaluation included comparing the frequency of major adverse cardiac events (MACE) (cardiac death, myocardial infarcпункtion [MI], stroke, repeat revascularization) and Kaplan-Mayer curves between groups of patients with and without LHI...
January 2018: Kardiologiia
https://www.readbyqxmd.com/read/29465306/sex-dimorphism-in-the-distribution-of-adipose-tissue-and-its-influence-on-proinflammatory-adipokines-and-cardiometabolic-profiles-in-motor-complete-spinal-cord-injury
#13
Gary J Farkas, Ashraf S Gorgey, David R Dolbow, Arthur S Berg, David R Gater
OBJECTIVE: We aimed to examine the influence of sex on the distribution of adipose tissue, as well as proinflammatory adipokine and cardiometabolic profiles, in chronic motor complete spinal cord injury (SCI). DESIGN: Cross-sectional and correlational study. SETTING: Academic rehabilitation hospital. PARTICIPANTS: Forty-seven individuals with chronic motor complete SCI classified according to sex (males: age 44.0 ± 10...
February 21, 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29462969/milk-an-effective-recovery-drink-for-female-athletes
#14
Paula Rankin, Adrian Landy, Emma Stevenson, Emma Cockburn
Milk has become a popular post-exercise recovery drink. Yet the evidence for its use in this regard comes from a limited number of investigations utilising very specific exercise protocols, and mostly with male participants. Therefore, the aim of this study was to investigate the effects of post-exercise milk consumption on recovery from a sprinting and jumping protocol in female team-sport athletes. Eighteen females participated in an independent-groups design. Upon completion of the protocol participants consumed 500 mL of milk (MILK) or 500 mL of an energy-matched carbohydrate (CHO) drink...
February 17, 2018: Nutrients
https://www.readbyqxmd.com/read/29460271/serpina1-gene-variants-in-granulomatosis-with-polyangiitis
#15
Malgorzata Hadzik-Blaszczyk, Aneta Zdral, Tadeusz M Zielonka, Ada Rozy, Renata Krupa, Andrzej Falkowski, Kazimierz A Wardyn, Joanna Chorostowska-Wynimko, Katarzyna Zycinska
Alpha-1 antitrypsin (A1AT) deficiency is one of the most common genetic disorders in Caucasian population. There is a link between granulomatosis with polyangiitis (GPA) and most frequent variants of SERPINA1 gene encoding severe alpha-1 antitripsin deficiency. However, the potential effect of Pi*Z, Pi*S as well as other SERPINA1 variants on clinical course of vasculitis are not well understood. The aim of the study was to analyze the potential effect of A1AT protein phenotype representing the SERPINA1 gene variants on the clinical course of GPA...
February 20, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29460097/prognostic-role-of-high-sensitivity-c-reactive-protein-and-interleukin-6-in-glioma-and-meningioma-patients
#16
Adomas Bunevicius, Andrius Radziunas, Sarunas Tamasauskas, Arimantas Tamasauskas, Edwards R Laws, Giorgio Iervasi, Robertas Bunevicius, Vytenis Deltuva
High sensitivity C-reactive protein (hsCRP) and interleukin-6 (IL-6) can be important prognostic indicators of brain tumor patients. We investigated the association of circulating IL-6 and hsCRP concentrations with discharge outcomes and survival of glioma and meningioma patients. One-hundred and sixty-three (115 women; median age 57 years) patients admitted for meningioma (n = 94), high-grade glioma (n = 48) and low-grade glioma (n = 21) surgery were enrolled in this prospective cohort study. Serum samples were collected within 24 h of admission...
February 19, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29458218/effects-of-curcuminoids-plus-piperine-on-glycemic-hepatic-and-inflammatory-biomarkers-in-patients-with-type-2-diabetes-mellitus-a-randomized-double-blind-placebo-controlled-trial
#17
Yunes Panahi, Nahid Khalili, Ebrahim Sahebi, Soha Namazi, Luis E Simental-Mendía, Muhammed Majeed, Amirhossein Sahebkar
INTRODUCTION: Curcuminoids have been shown to reduce glycemia and related complications in diabetes. In the present study, we evaluated the impact of curcuminoids plus piperine administration on glycemic, hepatic and inflammatory biomarkers in type 2 diabetes (T2D) patients. METHODS: T2D patients aged 18-65 years were enrolled in a randomized double-blind placebo-controlled trial and randomly allocated to standard-of-care treatment and dietary advises plus either curcuminoids (daily dose of 500 mg/day co-administered with piperine 5 mg/day) or placebo for a period of 3 months...
February 19, 2018: Drug Research
https://www.readbyqxmd.com/read/29456218/renal-anemia-syndromes-in-iraqi-hemodialysis-patients-according-to-iron-status
#18
Ala Ali, Riyadh M Salih
Anemia is common in patients on hemodialysis (HD). Adequate iron stores are essential for achieving the best hemoglobin level through maximum benefit from erythropoiesis-stimulating agents (ESA). Decreased iron stores or decreased availability of iron are the most common reasons for resistance to the effect of these agents. Our objective was to categorize a group of Iraqi HD patients according to absolute or functional iron deficiency anemia (IDA); this study was conducted in the HD unit of the Baghdad Teaching Hospital from October 2012 to January 2013...
January 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29454567/cilostazol-may-decrease-plasma-inflammatory-biomarkers-in-patients-with-recent-small-subcortical-infarcts-a-pilot-study
#19
Naoki Saji, Shigenobu Tone, Kenta Murotani, Yoshiki Yagita, Kazumi Kimura, Takashi Sakurai
BACKGROUND: The mechanism of progressive neurological deficit in patients with recent small subcortical infarcts has not yet been clarified. Inflammatory biomarkers and the use of cilostazol may be associated with this phenomenon. METHODS: Between May 2013 and April 2014, we evaluated consecutive first-ever patients with stroke due to recent small subcortical infarcts within 48 hours of onset. We divided patients into 2 groups according to the use of antiplatelet agents (cilostazol with or without aspirin versus aspirin alone)...
February 14, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29453140/serum-apolipoprotein-a-1-concentrations-and-the-prevalence-of-cardiovascular-autonomic-neuropathy-in-individuals-with-type-2-diabetes
#20
Jin Ook Chung, Seon-Young Park, Ji Hyun Han, Dong Hyeok Cho, Dong Jin Chung, Min Young Chung
OBJECTIVE: To evaluate the relationship between levels of serum apolipoproteins and the prevalence of cardiovascular autonomic neuropathy (CAN) in type 2 diabetes. METHODS: In total, 3199 individuals with type 2 diabetes were investigated in a cross-sectional study. The diagnosis of CAN was made based on the results of a cardiovascular reflex test. Serum apolipoprotein A-I (apoA-I) and apolipoprotein B (apoB) levels were measured. RESULTS: Serum apoA-1 levels were significantly low in individuals with CAN, but there was no significant association between serum apoB levels and CAN...
January 31, 2018: Journal of Diabetes and its Complications
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