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high sensitivity c-reactive protein

Aaron W Aday, Paul M Ridker
Inflammation is a critical pathway in the pathogenesis of atherosclerosis. Previous studies have shown that plasma levels of high-sensitivity C-reactive protein (hsCRP), a marker of inflammation, are associated with cardiovascular disease independent of traditional risk factors. Randomized trial data have also shown that statins reduce not only hsCRP but also cardiovascular event rates independent of their effect on low-density lipoprotein cholesterol (LDL-C) level. More recently, the CANTOS trial showed that directly reducing inflammation with canakinumab, an interleukin (IL)-1β neutralizing monoclonal antibody, could also reduce cardiovascular event rates...
2018: Frontiers in Cardiovascular Medicine
N Wu, G Yang
This study aims to evaluate the effect of sildenafil on pulmonary hypertension (PH) associated with chronic left heart failure. Twenty patients with PH and left heart failure were divided into treatment group (10 cases, with an oral dose of sildenafil 75 mg daily for 8 weeks) and control group (10 cases, with treatment of cardiac glycosides, diuretics, angiotensin-converting enzyme inhibitor, angiotensin II receptor blocker and beta-blockers). Left ventricular systolic function (LVEF), the pulmonary artery systolic pressure (PH), the left ventricular fraction shortening (LVFS), the left atrium diameter (LAD) and the left ventricular end-diastolic diameter (LVD) were measured by echocardiography, the left ventricular mass index (LVMI) was also calculated...
May 2018: Journal of Biological Regulators and Homeostatic Agents
Vinna An, Raaj Chandra, Matthew Lawrence
Anastomotic leak (AL) can be a devastating complication in colorectal surgery. While it is less frequent in the modern era, it still results in significant morbidity and mortality, prolonged hospital stays and increases the costs and demands on health services. There is inevitable interplay between patient physiology and technical factors that predispose a patient to AL. Obesity, preoperative total proteins, male gender, ongoing anticoagulant treatment, intraoperative complication and number of hospital beds have been identified as independent risk factors...
April 2018: Indian Journal of Surgery
Şerafettin Demir, Hüseyin Ede, Mehmet Kaplan, Fethi Yavuz, Ceyhun Yücel, İbrahim Halil Kurt
OBJECTIVE: The aim of this study is research relation of serum neopterin level with mortality and morbidity due to systolic HF and also its role in diagnosis of patients with systolic HF. MATERIAL AND METHODS: Eighty-one patients with systolic heart failure (HF group) and eighty-one age- and gender-matched healthy subjects (the control group) were enrolled in the study. Echocardiographic examination was performed accordingly. At the beginning of the study, serum B type natriuretic peptide (BNP), neopterin, and high sensitive C-reactive protein (hs-CRP) were measured accordingly...
June 18, 2018: Acta Cardiologica
Alp Atasoy, Evrim Çakır, Süleyman Ahbab, Yasemin Erdoğan Döventaş, Macit Koldaş, Esra Ataoğlu, Mustafa Yenigün
Background/aim: In parallel with increased frequency and higher quality of imaging techniques, the prevalence of adrenal adenoma has gradually increased. However, despite the growing incidence, the metabolic and tumorigenesis processes involved in its etiology are still unclear. Although visfatin has been reported to be associated with inflammation and tumorigenesis, its role in adrenal adenoma has not yet been investigated. Therefore, the present study was performed with an aim to evaluate visfatin levels and cardiometabolic risk factors in patients with adrenal adenoma...
June 14, 2018: Turkish Journal of Medical Sciences
Ayşe Ağbaş, Nur Canpolat, Salim Çalışkan, Alev Yılmaz, Hakan Ekmekçi, Mark Mayes, Helen Aitkenhead, Franz Schaefer, Lale Sever, Rukshana Shroff
Randomized trials in adults have shown reduced all-cause and cardiovascular mortality on hemodiafiltration (HDF) compared to high-flux hemodialysis (HD), but the mechanisms leading to improved outcomes are not clear. We studied biomarkers of inflammation, oxidative stress, anti-oxidant capacity and endothelial dysfunction in 22 children (13 female, age 8-15 years). All children received HD for at least 3 months, and were then switched to HDF, keeping all dialysis related parameters and dialysis time constant...
2018: PloS One
Tingbin Xie, Chenyan Zhao, Chao Ding, Liang Zhang, Minhua Cheng, Cao Chun, Wenkui Yu, Jianfeng Gong, Weiming Zhu
Background: The role of interleukin-6 (IL-6) in the prediction of intra-abdominal septic complications (IASCs) in patients with Crohn's disease (CD) remains unclear. We assessed the serum IL-6 time course and its association with postoperative IASCs in patients undergoing elective intestinal operations for CD. Methods: In total, 118 patients who underwent intestinal operations for CD were prospectively evaluated. They were divided into an IASC group and non-IASC group...
June 15, 2018: Inflammatory Bowel Diseases
Somlak Vanavanan, Pornpen Srisawasdi, Mana Rochanawutanon, Nalinee Kumproa, Khanat Kruthkul, Martin H Kroll
Background: Body mass index (BMI) and percentage of body fat (PBF) are used to measure obesity; however, their performance in identifying cardiometabolic risk in Southeast Asians is unclear. Generally, Asian women have higher PBF and lower BMI than do men and other ethnic populations. This study was conducted to address whether a discord exists between these measures in predicting obesity-related cardiometabolic risk in a Thai population and to test whether associations between the measures and risk factors for cardiovascular disease have a sex-specific inclination...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Christie M Ballantyne, Maciej Banach, G B John Mancini, Norman E Lepor, Jeffrey C Hanselman, Xin Zhao, Lawrence A Leiter
BACKGROUND AND AIMS: Patients with hyperlipidemia who are unable to tolerate optimal statin therapy are at increased cardiovascular risk due to ongoing elevations in low-density lipoprotein cholesterol (LDL-C). The objective of CLEAR Tranquility (NCT03001076) was to evaluate the efficacy and safety of bempedoic acid when added to background lipid-modifying therapy in patients with a history of statin intolerance who require additional LDL-C lowering. METHODS: This phase 3, multicenter, randomized, double-blind, placebo-controlled study enrolled patients with a history of statin intolerance and an LDL-C ≥100 mg/dL while on stable lipid-modifying therapy...
June 12, 2018: Atherosclerosis
Eric J Brunner, Martin J Shipley, Sara Ahmadi-Abhari, Carlos Valencia Hernandez, Jessica G Abell, Archana Singh-Manoux, Ichiro Kawachi, Mika Kivimaki
BACKGROUND: Health inequalities persist into old age. We aimed to investigate risk factors for socioeconomic differences in frailty that could potentially be modified through policy measures. METHODS: In this multi-wave longitudinal cohort study (Whitehall II study), we assessed participants' socioeconomic status, behavioural and biomedical risk factors, and disease status at age 45-55 years, and frailty (defined according to the Fried phenotype) at baseline and at one or more of three clinic visits about 18 years later (mean age 69 years [SD 5·9])...
June 13, 2018: Lancet. Public Health
Fei Shi, Chen Qiu, Jie Yu, Ying Yang, Binbin Li, Mengjie Feng, Ting Zhang, Wenwen Liu
The exact role of fractional exhaled nitric oxide (FeNO) in older patients with chronic inflammatory diseases including asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) remains unclear. This study aimed to investigate the differences in FeNO levels of elderly patients with ACO, asthma, COPD, and chronic cough. We conducted a retrospective study analysing the data of stable outpatients from Pulmonary Department of the Second Clinical College, Jinan University. All participants (Age≥55 years) were divided into the ACO group (n=19), asthma group (n=16), COPD group (n=25), and chronic cough group (n=22)...
June 2018: Iranian Journal of Allergy, Asthma, and Immunology
Agata Kowalczyk, Jakub P Sęk, Artur Kasprzak, Magdalena Poplawska, Ireneusz P Grudzinski, Anna M Nowicka
Simple, selective and sensitive analytical devices are of a great importance for medical application. Herein, we developed highly selective immunosensor for electrochemical detection of C-reactive protein (CRP) in blood sample. Branched polyethylenimine functionalized with ferrocene residues (PEI-Fc) was the main element of the recognition layer, which allowed: (i) covalent binding of an antibody in its most favorable orientation and (ii) voltammetric detection of the C-reactive protein. Anchoring of PEI-Fc to the electrode surface through the electrodeposition process leads to the formation of thin, stable and reproducible layers, which is extremely important in the case of electrochemical immunosensing...
June 13, 2018: Biosensors & Bioelectronics
Junji Moriya
There is accumulating evidence that vascular inflammation plays critical roles in pathophysiology of atherosclerosis. It is widely accepted that both innate and adaptive immune responses are important for initiation and progression of atherosclerosis, which mainly consist of monocytes, macrophages, neutrophils, T lymphocytes, and B lymphocytes. Moreover, inflammatory biomarkers such as high-sensitivity C-reactive protein and interleukin-6 are known to predict future cardiovascular events, as well as conventional low-density or high-density lipoprotein cholesterol...
June 12, 2018: Journal of Cardiology
Yadav Nisha, Zachariah Bobby, Vaibhav Wadwekar
PURPOSE: Evaluation of biochemical derangements related to metabolic syndrome in epileptic patients on treatment with Valproic acid. METHODS: This study consisted of two groups of 42 patients. Group I - Newly diagnosed patients with epileptic seizures untreated with any Anti-epileptic drugs (AEDs). Group II - Patients on treatment with Valproic acid for more than one year. Age and gender matched patients of 18-40 years were recruited. Patients who were diabetic, hypertensive, smokers, alcoholics, with persistent infection, head injuries, pregnancy and lactation were excluded from the study...
June 5, 2018: Seizure: the Journal of the British Epilepsy Association
Shogo Senga, Narumi Kobayashi, Koichiro Kawaguchi, Akira Ando, Hiroshi Fujii
Fatty acid-binding proteins (FABPs) are involved in binding and storing hydrophobic ligands such as long-chain fatty acids, as well as transporting them to the appropriate compartments in the cell. Epidermal fatty acid-binding protein (FABP5) is an intracellular lipid-binding protein that is abundantly expressed in adipocytes and macrophages. Previous studies have revealed that the FABP5 expression level is closely related to malignancy in various types of cancer. However, its precise functions in the metabolisms of cancer cells remain unclear...
June 12, 2018: Biochimica et Biophysica Acta
Mark A Blankestijn, Constance F den Hartog Jager, W Marty Blom, Henny G Otten, G Aard H de Jong, Marco Gaspari, Geert F Houben, André C Knulst, Kitty C M Verhoeckx
BACKGROUND: The role of sensitization to commercially available allergens of English walnut (Juglans regia) Jug r 1, 2 and 3 in walnut allergy has been previously investigated in walnut allergic adults and was unable to explain allcases of walnut allergy. OBJECTIVES: Identify recognized walnut allergens, other than the ones previously investigated (Jug r 1-3), in walnut allergic adults and determine the sensitization frequency and diagnostic value. METHODS: Three different in-house walnut extracts were prepared and analysed on SDS-PAGE blots to identify allergenic walnut proteins...
June 15, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
Qian Sun, Ronghe Chen, Fan Xin, Guohong Ruan
OBJECTIVE: To explore the effect of three kinds of drinking water and its possible mechanism on blood pressure of hypertensive mice. METHODS: The water quality parameters were measured for three kinds of drinking water, and the parameters includedtotal dissolved solids( TDS), oxygen consumed( OC), p H, oxidation reduction potential( ORP), electric conductivity( EC), dissolved hydrogen, calcium and magnesium. Establishment of mouse model of high blood pressure by using N'-nitro-L-arginine methyl ester hydrochloride( L-NAME) for 30 days...
November 2017: Wei Sheng Yan Jiu, Journal of Hygiene Research
Duane S Juang, Ching-Hui Lin, Yi-Ren Huo, Chia-Yu Tang, Chun-Ren Cheng, Hua-Shu Wu, Shih-Fen Huang, Alexander Kalnitsky, Chun-Cheng Lin
Here we report an electrochemical immunoassay platform called Proton-ELISA (H-ELISA) for the detection of bioanalytes. H-ELISA uniquely utilizes protons as an immunoassay detection medium, generated by the enzyme glucose oxidase (GOx) coupled with Fenton's reagent in a proton amplification reaction cascade that results in a highly amplified signal. A proton-sensitive dual-gated ion-sensitive field effect transistor (DG-ISFET) sensor was also developed for sensitive and accurate detection of the proton signal in H-ELISA...
June 7, 2018: Biosensors & Bioelectronics
(no author information available yet)
Reports an error in "Is daytime napping associated with inflammation in adolescents" by Karen P. Jakubowski, Martica H. Hall, Anna L. Marsland and Karen A. Matthews ( Health Psychology , 2016[Dec], Vol 35[12], 1298-1306). This erratum reports an error in Table 1. The unit of measurement for IL-6 should be pg/mL instead of mg/L. This error did not impact the results or the interpretation of the findings. (The following abstract of the original article appeared in record 2016-27321-001.) Objective: Daytime napping has been associated with poor health outcomes in adults...
July 2018: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
Anja Stundl, Laura Busse, Philipp Leimkühler, Marcel Weber, Berndt Zur, Fritz Mellert, Eberhard Grube, Georg Nickenig, Nikos Werner, Jan-Malte Sinning
AIMS: To assess the clinical value of biomarkers to identify TAVI-patients at high risk for ad-verse outcome, to assess whether these provide prognostic information beyond that of estab-lished clinical risk scores, and to assess whether a combined multi-marker strategy can im-prove clinical decision-making. METHODS AND RESULTS: In 683 TAVI-patients, biomarkers reflecting various pathophysiologic systems were measured before TAVI. The primary endpoint was all-cause 1-year mortality...
June 12, 2018: EuroIntervention
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