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high sensitivity c-reactive protein

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https://www.readbyqxmd.com/read/28086966/predictive-value-of-non-fasting-remnant-cholesterol-for-short-term-outcome-of-diabetics-with-new-onset-stable-coronary-artery-disease
#1
Li-Feng Hong, Xiao-Ni Yan, Zhen-Hua Lu, Ying Fan, Fei Ye, Qiong Wu, Song-Hui Luo, Bo Yang, Jian-Jun Li
BACKGROUND: The relationship between non-fasting remnant cholesterol and cardiovascular outcome in the era of potent statin therapy remained to be elucidated. METHODS: A cohort study of three hundred and twenty eight diabetics diagnosed with new-onset stable coronary artery disease (CAD) by coronary angiography were enrolled. All cases were followed up for an average duration of twelve months. The association between baseline remnant cholesterol levels and major cardiovascular outcomes were evaluated using the receivers operating characteristic (ROC) curves and Cox proportional hazards regression analysis...
January 13, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28078862/a-placebo-controlled-trial-of-a-proprietary-lipid-lowering-nutraceutical-supplement-in-the-management-of-dyslipidemia
#2
M Houston, R Rountree, J Lamb, S Phipps, S Meng, B Zhang
There is an ever growing emergence in the popularity of patient-driven care. As this health and wellness model grows, inquiries into diet, lifestyle, and supplemental approaches will continue to become a focal point for the healthcare consumer. Because of this, the aim of this study is to determine the tolerability, and overall effectiveness of a proprietary multi-ingredient lipid-lowering supplement in subjects with dyslipidemia. Forty participants were recruited for a single-center, double-blind randomized, placebocontrolled trial...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28077136/increased-leptin-adiponectin-ratio-relates-to-low-normal-thyroid-function-in-metabolic-syndrome
#3
Lynnda J N van Tienhoven-Wind, Robin P F Dullaart
BACKGROUND: Low-normal thyroid function within the euthyroid range may contribute to increased atherosclerosis susceptibility. The leptin/adiponectin (L/A) ratio is associated with cardiovascular disease and reflects adipose tissue dysfunction. Relationships of the L/A ratio with low-normal thyroid function are unknown. METHODS: Relationships of thyroid stimulating hormone (TSH) and free thyroxine (free T4) with leptin, adiponectin and the L/A ratio in euthyroid subjects were documented in 67 fasting subjects with metabolic syndrome (Mets) and 86 euthyroid subjects without MetS (TSH and free T4 levels within the institutional reference range)...
January 11, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28077069/a-pilot-study-of-brisk-walking-in-sedentary-combination-antiretroviral-treatement-cart-treated-patients-benefit-on-soluble-and-cell-inflammatory-markers
#4
Matteo Bonato, Laura Galli, Laura Passeri, Valeria Longo, Gaspare Pavei, Simona Bossolasco, Cecilia Bertocchi, Massimo Cernuschi, Giuseppe Balconi, Giampiero Merati, Adriano Lazzarin, Antonio La Torre, Paola Cinque
BACKGROUND: Chronic HIV infection is associated with low-level inflammation and increased risk of chronic diseases and mortality. The objective was to assess the effects of moderate intensity exercise on metabolic and inflammatory markers in HIV-infected treated persons. METHODS: This was a pilot study enrolling cART-treated, sedentary persons with metabolic complications in a 12-week protocol, consisting of three sessions per week of 60 min brisk walking with (strength-walk group) or without (walk group) 30 min circuit-training...
January 11, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28074977/-association-of-c-reactive-protein-levels-with-metabolic-syndrome-in-adults-a-population-based-study
#5
Patricia Bustos, Bernardita Rosas, Pablo Román, Juan Villagrán, Hugo Amigo
BACKGROUND: Metabolic syndrome is highly prevalent among adults in Chile and represents a health risk. AIM: To determine the relationship between metabolic syndrome (MetS) and its components, with C reactive protein levels (CRP) as an inflammation marker. MATERIAL AND METHODS: The population studied consisted of 736 individuals born in a hospital from Valparaíso Region, aged between 32-38 years at the time of the study. MetS was identified according to the Adult Treatment Panel (ATP) III guidelines and inflammation was measured using ultra-sensitive CRP...
October 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/28072742/the-nonlinear-association-between-apolipoprotein-b-to-apolipoprotein-a1-ratio-and-type-2-diabetes
#6
Yong Mao, Yang Xu, Leihong Lu
The ratio of ApoB/apolipoprotein A1 (ApoA1) has been found to be associated with type 2 diabetes, and it was proposed as a new biomarker for type 2 diabetes predictions. Previous studies have assumed that the association between apoB/apoA1 and type 2 diabetes was linear. However, the linearity assumption has rarely been examined. In the present study, we aimed to examine whether this association showed a linear trend in a nationally representative population.Participants aged 18 years and over (n = 8220) were selected from the China Health Nutrition Survey (CHNS)...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28072726/no-further-gain-can-be-achieved-by-calculating-disease-activity-score-in-28-joints-with-high-sensitivity-assay-of-c-reactive-protein-because-of-high-intraindividual-variability-of-c-reactive-protein-a-cross-sectional-study-and-theoretical-consideration
#7
Inger M J Hansen, Amir Emamifar, Rikke A Andreasen, Steen Antonsen
Disease Activity Score in 28 joints (DAS28) is commonly used to evaluate disease activity of rheumatoid arthritis (RA) and is a guide to treatment decision.The aim of this study was to evaluate the impact of lower reporting limit for C-reactive protein (CRP), with respect to intraindividual biological variability, on the calculation of DAS28 and subsequent patient classification.This study consists of 2 sections: a theoretical consideration discussing the performance of CRP in calculating DAS28 taking intraindividual biological variation and lower reporting limit for CRP into account and a cross-sectional study of RA patients applying our theoretical results...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28071854/serum-chemerin-is-associated-with-inflammatory-and-metabolic-parameters-results-of-a-population-based-study
#8
Stephanie Zylla, Maik Pietzner, Jens-Peter Kühn, Henry Völzke, Marcus Dörr, Matthias Nauck, Nele Friedrich
OBJECTIVE: This study aimed to confirm existing assumptions about the associations of circulating chemerin with inflammatory and metabolic parameters in a large population-based study. METHODS: Data of 3,986 subjects from the Study of Health in Pomerania were analyzed. Residual method was used to investigate the different associations of visceral (VAT) and subcutaneous adipose tissue (SAT) with serum chemerin levels. Multivariable regression models were applied to examine the association of chemerin with high-sensitivity C-reactive protein, fibrinogen, glucose, glycated hemoglobin, lipid profile, blood pressure, diabetes, dyslipidemia, and hypertension...
January 10, 2017: Obesity
https://www.readbyqxmd.com/read/28069837/high-sensitive-cardiac-troponin-t-as-a-novel-predictor-for-recurrence-of-atrial-fibrillation-after-radiofrequency-catheter-ablation
#9
Koki Nakanishi, Shota Fukuda, Hajime Yamashita, Toshifumi Hasegawa, Michihiko Kosaka, Naoya Shirai, Kenei Shimada, Junichi Yoshikawa, Atsushi Tanaka
AIMS: We aimed to determine whether elevated serum high-sensitive cardiac troponin T (hs-TnT) levels predict atrial fibrillation (AF) recurrence after pulmonary vein isolation (PVI). METHODS AND RESULTS: We included 125 consecutive patients with AF (paroxysmal, n = 79; persistent, n = 46) who underwent first-time PVI. Serum hs-TnT, high-sensitive C-reactive protein (hs-CRP), atrial natriuretic peptide, and plasma B-type natriuretic peptide levels were measured in venous samples collected before PVI...
January 8, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28067869/clinical-and-biological-markers-of-premature-aging-after-autologous-sct-in-childhood-cancer
#10
A Vatanen, M Hou, T Huang, O Söder, T Jahnukainen, M Kurimo, T H Ojala, T Sarkola, M Turanlahti, U M Saarinen-Pihkala, K Jahnukainen
The aim of this study was to analyze the prevalence of frailty and physical health limitations among long-term survivors of high-risk neuroblastoma (HR NBL) and to investigate whether frail health is associated with variables of cardiovascular function, markers of inflammation and telomere length. A national study cohort of 19 (median age 22, range 16-30 years) long-term (>10 years) HR NBL survivors was studied and the findings were compared with 20 age- and sex-matched controls. Frailty was defined as ⩾3 of the following conditions: low muscle mass, low energy expenditure, slow running and weakness...
January 9, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28066689/c-reactive-protein-in-stable-cystic-fibrosis-an-additional-indicator-of-clinical-disease-activity-and-risk-of-future-pulmonary-exacerbations
#11
Elias Matouk, Dao Nguyen, Andrea Benedetti, Joanie Bernier, James Gruber, Jennifer Landry, Simon Rousseau, Heather G Ahlgren, Larry C Lands, Gabriella Wojewodka, Danuta Radzioch
INTRODUCTION: In stable adult cystic fibrosis (CF) patients, we assessed the role of baseline high sensitivity C-reactive protein (hs-CRP) on CF clinical variables and frequency of intravenous (IV) treated pulmonary exacerbations (PExs) 1-year post-baseline. METHODS: We recruited 51 clinically stable CF patients from our Adult CF Center. We incorporated collected parameters into Matouk CF clinical score and CF questionnaire-revised quality of life score (QOL). We used the clinical minus complications subscores as a clinical disease activity score (CDAS)...
October 14, 2016: Journal of Pulmonary & Respiratory Medicine
https://www.readbyqxmd.com/read/28064554/evaluating-bempedoic-acid-for-the-treatment-of-hyperlipidaemia
#12
Peter Penson, Mary McGowan, Maciej Banach
Despite the effectiveness of statins in the treatment of lipid disorders, residual risk still exists, and hitherto studies where additional drugs were added to statin therapy have been mainly negative or the outcomes were very modest. Therefore there is still a need for new and effective oral agents in the combination therapy of lipid disorders. Areas Covered: The review covers the current state of knowledge on the mechanism of action of bempedoic acid (ETC-1002) and results from recent clinical studies. Expert Opinion: ETC-1002 is a novel oral lipid-lowering therapy...
January 9, 2017: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/28064233/clozapine-associated-with-autoimmune-reaction-fever-and-low-level-cardiotoxicity-a-case-report
#13
Charilaos Gerasimou, Georgia Phaedra Vitali, George D Vavougios, Charalabos Papageorgiou, Athanasios Douzenis, Styliani I Kokoris, Ioannis Liappas, Emmanouil Rizos
BACKGROUND: Clozapine is a second-generation antipsychotic drug used in treatment-resistant schizophrenia. Fever induced by clozapine is a rather frequent side-effect which usually occurs in the first 4 weeks of treatment. Despite its effectiveness, there are potentially life-threatening adverse effects, such as cardiotoxicity. CASE REPORT: We present the case of a 31-year-old caucasian male with refractory schizophrenia who developed benign fever, increase of C-reactive protein and high troponin levels, without presenting any other signs to myocarditis, on the 13th day under clozapine treatment, which declined progressively upon discontinuation of the drug...
January 2017: In Vivo
https://www.readbyqxmd.com/read/28064096/high-glucose-induced-lif-suppresses-osteoblast-differentiation-via-regulating-stat3-socs3-signaling
#14
Changlu Liu, Dianming Jiang
High glucose (HG) is conceived to regulate bone metabolism in patients with diabetic mellitus (DM). In the present study, we examined the level of leukemia inhibitory factor (LIF), a pleiotropic cytokine in interleukin (IL)-6 family, in T2DM patients and investigated the regulation by HG on the induction of LIF/signal transducer and activator of transcription 3 (STAT3) signaling. Then we determined the regulation of HG and LIF on the osteoblast differentiation via measuring the ALP activity, matrix mineralization, and the expression of alkaline phosphatase (ALP), Runt-related transcription factor 2 (RUNX2), Osteocalcin (OCN) and osteopontin (OPN) in human osteoblast MG-63 cells...
January 5, 2017: Cytokine
https://www.readbyqxmd.com/read/28062948/low-levels-of-prohibitin-in-substantia-nigra-makes-dopaminergic-neurons-vulnerable-in-parkinson-s-disease
#15
Debashis Dutta, Nilufar Ali, Emili Banerjee, Raghavendra Singh, Amit Naskar, Ramesh Kumar Paidi, Kochupurackal P Mohanakumar
Since substantia nigra (SN) and ventral tegmental area (VTA) dopaminergic neurons are, respectively, susceptible or largely unaffected in Parkinson's disease (PD), we searched for protein(s) that regulates this differential sensitivity. Differentially, expressed proteins in SN and VTA were investigated employing two-directional gel electrophoresis- matrix-assisted laser desorption ionization time of flight (MALDI-TOF-TOF) analyses. Prohibitin, which is involved in mitochondrial integrity, was validated using immunoblot, qRT-PCR, and immunohistochemistry in normal mice as well as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-model, PD postmortem human brains, and PD cybrids...
January 6, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28062625/high-sensitivity-troponin-i-in-stable-patients-with-atherosclerotic-disease-in-the-tra-2%C3%A2-p-timi-50-trial
#16
Alon Eisen, Marc P Bonaca, Petr Jarolim, Benjamin M Scirica, Harvey D White, Michal Tendera, Mikael Dellborg, Jose C Nicolau, Joao Morais, Keith A A Fox, Erin A Bohula, Sabina A Murphy, Eugene Braunwald, David A Morrow
BACKGROUND: Cardiac troponin I, measured with a high-sensitivity assay (hs-TnI), is well-established for risk prediction in acute coronary syndromes. However, its prognostic role in stable atherosclerotic disease, particularly for future myocardial infarction (MI), is less well defined. METHODS: We measured hs-TnI (Abbott ARCHITECT) in 15833 patients with prior MI, ischemic stroke, or peripheral arterial disease from the placebo-controlled Thrombin Receptor Antagonist in Secondary Prevention of Atherothrombotic Ischemic Events (TRA 2°P)-Thrombolysis in Myocardial Infarction (TIMI) 50 trial of the platelet inhibitor vorapaxar, excluding patients with recent MI (<30 days)...
January 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28061502/brain-abscesses-associated-with-asymptomatic-pulmonary-arteriovenous-fistulas
#17
Taek-Kyun Nam, Yong-Sook Park, Jeong-Taik Kwon
Brain abscess commonly occurs secondary to an adjacent infection (mostly in the middle ear or paranasal sinuses) or due to hematogenous spread from a distant infection or trauma. Pulmonary arteriovenous fistulas (AVFs) are abnormal direct communications between the pulmonary artery and vein. We present two cases of brain abscess associated with asymptomatic pulmonary AVF. A 65-year-old woman was admitted with a headache and cognitive impairment that aggravated 10 days prior. An magnetic resonance (MR) imaging revealed a brain abscess with severe edema in the right frontal lobe...
January 1, 2017: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/28060925/associations-of-self-reported-sleep-quality-with-circulating-interferon-gamma-inducible-protein-10-interleukin-6-and-high-sensitivity-c-reactive-protein-in-healthy-menopausal-women
#18
Wan-Yu Huang, Chih-Cheng Huang, Chia-Chu Chang, Chew-Teng Kor, Ting-Yu Chen, Hung-Ming Wu
INTRODUCTION: Sleep disturbance is very common in menopausal women and poor sleep quality has been linked to systemic inflammation. However, the impact of poor sleep quality on health outcomes of menopausal women remains unclear. This study evaluated the relationships between sleep quality and inflammation in menopausal women. PARTICIPANTS AND DESIGN: This cross-sectional study enrolled 281 healthy women aged 45 to 60 years. The Pittsburgh Sleep Quality Index (PSQI) was used to measure quality of sleep...
2017: PloS One
https://www.readbyqxmd.com/read/28056529/anterior-tragal-crease-is-associated-with-atherosclerosis
#19
Pawinee Rerknimitr, Korbkarn Pongpairoj, Chanat Kumtornrat, Ratchathorn Panchaprateep, Cameron P Hurst, Aurauma Chutinet, Pravit Asawanonda, Nijasri C Suwanwela
The utility of the ear crease sign, anterior tragal crease (ATC), as a marker of atherosclerosis is yet to be established. The intima-media thickness of the common carotid artery (IMT-CCA) has been used as a noninvasive surrogate marker for atherosclerosis. History of traditional risk factors for atherosclerosis was obtained from 147 volunteers; ear examination was also performed and venous blood was drawn for laboratory analysis. The volunteers then underwent an ultrasonography measurement of the IMT-CCA. In univariate analysis, presence of ATC, age, underlying hypertension, diabetes mellitus, ischemic heart disease, cerebrovascular disease, cigarette smoking, low-density lipoprotein, and high-sensitivity C-reactive protein were significantly associated with the IMT-CCA...
January 1, 2017: Angiology
https://www.readbyqxmd.com/read/28056237/-normal-value-and-reference-value-range-of-brachial-ankle-pulse-wave-velocity-among-kailuan-study-population
#20
J S Gao, L Song, Y T Wu, X M Zheng, X H Zhao, J Yang, C Y Ruan, H L Zhao, C H Li, Y M Wang, S H Chen, S L Wu
Objective: To establish the normal and reference values of brachial-ankle pulse wave velocity(baPWV) based on Kailuan study population. Methods: There were 22 622 staffs of Kailuan Group who underwent 2010 to 2015 health check-up and baPWV measurement. Data of 20 622 staffs were analyzed after excluding 2 000 staffs due to incomplete data. Of these, 9 109 normal individuals were selected for final analysis of normal and reference values for baPWV after excluding 8 788 staffs who had myocardial infarction, stroke, diabetes, hypertension history, treated by either anti-hypertensive or lipid-lowering drugs, and 2 725 smoker...
December 24, 2016: Zhonghua Xin Xue Guan Bing za Zhi
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