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https://www.readbyqxmd.com/read/28319848/treatment-of-premenstrual-dysphoric-disorder-with-the-gabaa-receptor-modulating-steroid-antagonist-sepranolone-uc1010-a-randomized-controlled-trial
#1
Marie Bixo, Karin Ekberg, Inger Sundström Poromaa, Angelica Lindén Hirschberg, Aino Fianu Jonasson, Lotta Andréen, Erika Timby, Marianne Wulff, Agneta Ehrenborg, Torbjörn Bäckström
CONTEXT: Allopregnanolone is a metabolite from progesterone and a positive modulator of the GABAA receptor. This endogenous steroid may induce negative mood in sensitive women when present in serum levels comparable to the premenstrual phase. Its endogenous isomer, isoallopregnanolone, has been shown to antagonize allopregnanolone effects in experimental animal and human models. OBJECTIVE: The objective was to test whether inhibition of allopregnanolone by treatment with the GABAA modulating steroid antagonist (GAMSA) Sepranolone (UC1010) during the premenstrual phase could reduce symptoms of the premenstrual dysphoric disorder (PMDD)...
March 1, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28318414/the-prevalence-of-self-reported-premenstrual-symptoms-and-evaluation-of-regular-exercise-with-premenstrual-symptoms-among-female-employees-in-taiwan
#2
Su-Ying Tsai, Fu-Chen Kuo, Hsin-Chih Kuo, Li-Ling Liao
Few studies have focused on premenstrual symptoms in employees. This study explored the prevalence of premenstrual symptoms in 7,193 female employees aged 18-55 years in a large electronics manufacturer in Taiwan from August 2014 to December 2014 and examined whether regular exercise was associated with premenstrual symptoms. Information was collected on demographics, lifestyle, menstrual history, menstrual pain, and premenstrual symptoms. Half of the participants reported irregular menstruation; 79.4% reported a moderate menstruation amount, and half reported little impact of menstrual pain at work...
March 20, 2017: Women & Health
https://www.readbyqxmd.com/read/28287918/premenstrual-syndrome-is-associated-with-a-higher-frequency-of-female-sexual-difficulty-and-sexual-distress
#3
Gülşah İlhan, Fatma Verda Verit Atmaca, Meryem Kurek Eken, Hürkan Akyol
BACKGROUND/AIMS: Few prospective studies have evaluated the impact of premenstrual symptoms (PMS) on female sexual function and sexuality related distress. Therefore the purpose of the present study was to find out risk factors of PMS for  female sexual function and sexuality related personal distress. METHODS: This prospective cohort study was conducted at the Suleymaniye women's health and disease, research and education hospital, Istanbul, Turkey between February 2014 and March 2016...
March 13, 2017: Journal of Sex & Marital Therapy
https://www.readbyqxmd.com/read/28277114/interdisciplinary-consensus-on-management-of-premenstrual-disorders-in-switzerland
#4
Petra Stute, Christine Bodmer, Ulrike Ehlert, Roger Eltbogen, Ankica Ging, Isabelle Streuli, Michael von Wolff
Premenstrual disorders (PMD) can affect women throughout their entire reproductive years. In 2016, an interdisciplinary expert meeting of general gynecologists, gynecological endocrinologists, psychiatrists and psychologists from Switzerland was held to provide an interdisciplinary algorithm on PMD management taking reproductive stages into account. The Swiss PMD algorithm differentiates between primary and secondary PMD care providers incorporating different levels of diagnostic and treatment. Treatment options include cognitive behavioral therapy, alternative therapy, antidepressants, ovulation suppression and diuretics...
March 2, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28277106/premenstrual-syndrome-and-fibromyalgia-the-frequency-of-the-coexistence-and-their-effects-on-quality-of-life
#5
Feray Soyupek, Cigdem Aydogan, Mehmet Guney, Seyit Ali Kose
OBJECTIVE: We aimed to investigate the association between Premenstrual syndrome (PMS) and fibromyalgia syndrome (FMS), to assess common symptoms and quality of life (QOL) of them. METHODS: Patients with PMS formed the PMS group and age-matched healthy normal controls were included in the control group. The diagnosis of the FMS and PMS were based on new American College of Rheumatology FMS criteria and DSM-IV PMS criteria. FMS-related symptoms assessed by visual analog scale and number of tender points (TePs) were analyzed...
March 5, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28258639/resting-state-functional-connectivity-in-women-with-bipolar-disorder-during-clinical-remission
#6
Sabrina K Syan, Luciano Minuzzi, Mara Smith, Olivia R Allega, Geoffrey Bc Hall, Benicio N Frey
OBJECTIVES: Periods of euthymia in bipolar disorder (BD) serve as a valuable time to study trait-based pathophysiology. The use of resting state functional connectivity (Rs-FC) can aid in the understanding of BD pathophysiology free of task or mood state biases. The present study investigated two unexplored areas of Rs-FC research in bipolar remission: (i) Rs-FC in women, controlling for the potential influence of premenstrual symptoms, and (ii) the use of both independent component analysis (ICA) and seed-based analysis (SBA) to investigate Rs-FC...
March 4, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28257559/non-contraceptive-oestrogen-containing-preparations-for-controlling-symptoms-of-premenstrual-syndrome
#7
REVIEW
Bushra Naheed, Jan Herman Kuiper, Olalekan A Uthman, Fidelma O'Mahony, Patrick Michael Shaughn O'Brien
BACKGROUND: Premenstrual syndrome (PMS) is a psychological and somatic disorder of unknown aetiology, with symptoms typically including irritability, depression, mood swings, bloating, breast tenderness and sleep disturbances. About 3% to 10% of women who experience these symptoms may also meet criteria for premenstrual dysphoric disorder (PMDD). PMS symptoms recur during the luteal phase of the menstrual cycle and reduce by the end of menstruation. PMS results from ovulation and may be due to ovarian steroid interactions relating to neurotransmitter dysfunction...
March 3, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28255462/profiling-proteins-in-the-hypothalamus-and-hippocampus-of-a-rat-model-of-premenstrual-syndrome-irritability
#8
Mingqi Qiao, Peng Sun, Yang Wang, Sheng Wei, Xia Wei, Chunhong Song, Fushun Wang, Jibiao Wu
Premenstrual syndrome (PMS) refers to several physical and mental symptoms (such as irritability) commonly encountered in clinical gynaecology. The incidence of PMS has been increasing, attracting greater attention from medical fields. However, PMS pathogenesis remains unclear. This study employed two-dimensional gel electrophoresis (2DE) for proteomic map analysis of the hypothalamus and hippocampus of rat models of premenstrual syndrome (PMS) irritability. Matrix-assisted laser desorption/ionisation time of flight mass spectroscopy (MALDI-TOF-MS) was used to identify proteins possibly related with PMS irritability...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/28251894/characteristics-of-premenstrual-acne-flare-up-and-benefits-of-a-dermocosmetic-treatment-a-double-blind-randomised-trial
#9
Mélanie Saint-Jean, Amir Khammari, Sophie Seite, Dominique Moyal, Brigitte Dreno
To date, facial acne flare-ups in adult women during the luteal phase of the menstrual cycle have been poorly investigated. To clinically characterize premenstrual acne flare-up in adult women and investigate the effect of a dermocosmetic treatment. This single-centre study included 32 young adult women with declared premenstrual acne flares and was composed of two phases: (1) an observational phase (two menstrual cycles) and (2) an interventional phase (one menstrual cycle) in a controlled, randomised, double-blind, intra-individual (half-face) setting in which a dermocosmetic (containing lipohydroxyacid, nicotinamide, and piroctone-olamine) and placebo were compared...
March 1, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/28250680/vestibular-stimulation-for-management-of-premenstrual-syndrome
#10
Minu Johny, Sai Sailesh Kumar, Archana Rajagopalan, Joseph Kurien Mukkadan
OBJECTIVES: The present study was undertaken to observe the effectiveness of vestibular stimulation in the management of premenstrual syndrome (PMS). MATERIALS AND METHODS: The present study was an experimental study; twenty female participants of age group 18-30 years were recruited in the present study. Conventional swing was used to administer vestibular stimulation. Variables were recorded before and after vestibular stimulation and compared. RESULTS: Depression and stress scores are significantly decreased after 2 months of intervention...
January 2017: Journal of Natural Science, Biology, and Medicine
https://www.readbyqxmd.com/read/28243425/systematic-review-of-premenstrual-postmenstrual-and-infertility-disorders-of-vitex-agnus-castus
#11
REVIEW
Mahmoud Rafieian-Kopaei, Mino Movahedi
INTRODUCTION: Vitex agnus-castus, also called vitex is aboriginal to the Mediterranean region, with long leaves, tender stem, flowers and ripening seeds. The aim of this study was to overview premenstrual, postmenstrual and infertility disorder of Vitex agnus-castus. METHODS: This review article was carried out by searching studies in PubMed, Medline, Web of Science, and IranMedex databases. The initial search strategy identified about 87 references. In this study, 43 studies were accepted for further screening, and met all our inclusion criteria (in English, full text, therapeutic effects of Vitex agnus-castus and dated mainly from the year 2009 to 2016)...
January 2017: Electronic Physician
https://www.readbyqxmd.com/read/28243196/abnormal-spontaneous-brain-activity-in-women-with-premenstrual-syndrome-revealed-by-regional-homogeneity
#12
Hai Liao, Yong Pang, Peng Liu, Huimei Liu, Gaoxiong Duan, Yanfei Liu, Lijun Tang, Jien Tao, Danhong Wen, Shasha Li, Lingyan Liang, Demao Deng
Background: Previous studies have revealed that the etiologies of premenstrual syndrome (PMS) refer to menstrual cycle related brain changes. However, its intrinsic neural mechanism is still unclear. The aim of the present study was to assess abnormal spontaneous brain activity and to explicate the intricate neural mechanism of PMS using resting state functional magnetic resonance imaging (RS-fMRI). Materials and Methods: The data of 20 PMS patients (PMS group) and 21 healthy controls (HC group) were analyzed by regional homogeneity (ReHo) method during the late luteal phase of menstrual cycle...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28237870/the-treatment-of-premenstrual-syndrome-with%C3%A2-preparations-of-vitex-agnus-castus-a%C3%A2-systematic-review-and-meta-analysis
#13
REVIEW
Saskia Verkaik, Astrid M Kamperman, Roos van Westrhenen, Peter F J Schulte
OBJECTIVE: Our objective was to determine the efficacy, tolerability, and acceptability of Vitex agnus castus preparations for treatment of premenstrual syndrome. STUDY DESIGN: All journals in the OVID software from inception through January 2016 were searched, including the Cochrane Central Register of Controlled Trials, MEDLINE, Embase, and PsycINFO. Gray literature was searched by Google Scholar and manufacturers of Vitex agnus castus preparations were contacted for information about unpublished trials...
February 22, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28222642/prediction-of-intraoperative-nausea-and-vomiting-in-caesarean-delivery-under-regional-anaesthesia
#14
Altuğ Semiz, Yaşam Kemal Akpak, Necip Cihangir Yılanlıoğlu, Ali Babacan, Gökhan Gönen, Canan Çam Gönen, Murat Asıliskender, Selim Karaküçük
Objectives This study aimed to predict patients who have caesarean operations under regional anaesthesia and are at risk for intraoperative nausea and vomiting (IONV), for ultimately prompting anaesthetists and surgeons to take preventive measures. Methods This was a retrospective study on 209 patients who had caesarean section under spinal-epidural combined regional anaesthesia. The relevant medical history, such as severe nausea and vomiting in the first trimester, smoking, a history of motion sickness, and premenstrual syndrome (PMS), were obtained from the patients' records and interviews...
February 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28217679/effect-of-calcium-on-premenstrual-syndrome-a-double-blind-randomized-clinical-trial
#15
Fatemeh Shobeiri, Fahimeh Ezzati Araste, Reihaneh Ebrahimi, Ensiyeh Jenabi, Mansour Nazari
OBJECTIVE: Premenstrual syndrome (PMS) affects millions of women and is known as the most important disorder among them. The very aim of the present study was to evaluate the effects of low dose calcium on severity of PMS. METHODS: This study can be considered as a double-blind randomized clinical trial. Female students of Hamadan University of Medical Sciences diagnosed with PMS in 2014 participated in the present study. Sixty-six female students diagnosed with PMS were involved in the experimental and control groups...
January 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28193300/predictors-of-premenstrual-impairment-among-women-undergoing-prospective-assessment-for-premenstrual-dysphoric-disorder-a-cycle-level-analysis
#16
K M Schmalenberger, T A Eisenlohr-Moul, P Surana, D R Rubinow, S S Girdler
BACKGROUND: Women who experience significant premenstrual symptoms differ in the extent to which these symptoms cause cyclical impairment. This study clarifies the type and number of symptoms that best predict premenstrual impairment in a sample of women undergoing prospective assessment for premenstrual dysphoric disorder (PMDD) in a research setting. Central research goals were to determine (1) which emotional, psychological, and physical symptoms of PMDD are uniquely associated with premenstrual impairment, and (2) how many cyclical symptoms optimally predict the presence of a clinically significant premenstrual elevation of impairment...
February 14, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28188965/effect-of-zinc-sulfate-supplementation-on-premenstrual-syndrome-and-health-related-quality-of-life-clinical-randomized-controlled-trial
#17
Shiva Siahbazi, Samira Behboudi-Gandevani, Lida Moghaddam-Banaem, Ali Montazeri
AIM: The purpose of study was to assess the effect of zinc sulfate (ZS) supplementation on premenstrual syndrome (PMS) and health-related quality of life (QoL). METHODS: This was a double-blind randomized and placebo-controlled trial using the parallel technique conducted between June 2013 and May 2014. A total of 142 women (age, 20-35 years) with PMS were allocated to either the ZS or placebo group. The women in the intervention group received ZS 220-mg capsules (containing 50 mg elemental zinc) from the 16th day of the menstrual cycle to the second day of the next cycle...
February 11, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28178022/the-impact-of-essential-fatty-acid-b-vitamins-vitamin-c-magnesium-and-zinc-supplementation-on-stress-levels-in-women-a-systematic-review
#18
Delia McCabe, Karolina Lisy, Craig Lockwood, Marc Colbeck
BACKGROUND: Women juggling multiple roles in our complex society are increasingly experiencing psychological stress. Dietary supplementation to manage stress is widespread despite limited supporting evidence. A systematic review of the available literature was undertaken to investigate the efficacy of specific dietary supplements in managing female stress and anxiety. OBJECTIVES: To identify the impact of essential fatty acids (EFAs), B vitamins, vitamin C, magnesium and/or zinc, consumed as dietary supplements to the daily diet, on female stress and anxiety levels...
February 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28152471/subtle-persistent-working-memory-and-selective-attention-deficits-in-women-with-premenstrual-syndrome
#19
Anastasiya Slyepchenko, Sonali Lokuge, Brianne Nicholls, Meir Steiner, Geoffrey B C Hall, Claudio N Soares, Benicio N Frey
As a recurrent, cyclical phenomenon, premenstrual syndrome (PMS) affects a significant proportion of women of the reproductive age, and leads to regular monthly days of functional impairment. Symptoms of PMS include somatic and psychological symptoms, such as headaches, sleep disturbances, social withdrawal and mood changes, during the late luteal phase of the menstrual cycle, which alleviate during the follicular phase. This study investigated neurocognitive functioning in women with moderate to severe PMS symptoms (n=13) compared to women with mild/no PMS (n=27) through administration of a battery of neuropsychological tests during the asymptomatic follicular phase of the menstrual cycle...
March 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28129701/how-gender-affects-the-pharmacotherapeutic-approach-to-treating-psychosis-a-systematic-review
#20
REVIEW
Bettina Lange, Juliane K Mueller, F Markus Leweke, J Malte Bumb
The effectiveness, effective dosages and side effect profiles of antipsychotic medication differ significantly between the sexes. Areas covered: We present a systematic review of gender-differences in the treatment of psychosis focusing on randomized, controlled trials and meta-analyses. Expert opinion: Despite many years of research, the database on gender-differences affecting the pharmacotherapeutic approach to treating psychosis is insufficient. Currently, the US National Institute of Health encouraged the enrolment of female participants in federally supported phase III clinical trials to increase the data available of female patients...
March 2017: Expert Opinion on Pharmacotherapy
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