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https://www.readbyqxmd.com/read/28096850/expression-analysis-of-multiple-genes-may-involve-in-antimony-resistance-among-leishmania-major-clinical-isolates-from-fars-province-central-iran
#1
Nafiseh Ghobakhloo, Mohammad Hossein Motazedian, Majid Fardaei
BACKGROUND: Treatment of Cutaneous Leishmaniasis (CL) is being faced with serious difficulties in Fars Province, due to emerging of resistance against meglumine antimonite (Glucantime®). In this context, determining some biomarkers for drug sensitivity monitoring seems to be highly essential. Different studies have been carried out to decipher the genes might be involved in antimony resistant phenotype in Leishmania spp. Here, we selected three genes: AQP (as drug transporter), TDR-1-1(as drug activator), and γ-GCS (inducing reduction environment) for comparative expression analysis on clinical resistant and sensitive isolates of L...
April 2016: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/28090051/different-effects-of-tolvaptan-in-patients-with-idiopathic-membranous-nephropathy-with-nephrotic-syndrome
#2
Atsushi Tanaka, Tsukasa Nakamura, Eiichi Sato, Yoshihiko Ueda, Koichi Node
This case report discusses the clinical indication for immunosuppressants in patients with idiopathic membranous nephropathy (IMN). Because this disease occasionally shows spontaneous remission, it is necessary to determine the predictive values for a therapeutic effect in order to provide appropriate treatment. Two distinct cases described herein illustrate the different effects of tolvaptan in responders and non-responders, according to the pre-treatment levels of AQP-2 immunostaining in the samples from renal biopsy and urinary levels of AQP-2 and osmolality, suggesting that these values may be useful predictors of response to tolvaptan in patients with nephrotic IMN...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28071581/role-of-aqp4-antibody-serostatus-and-its-prediction-of-visual-outcome-in-neuromyelitis-optica-a-systematic-review-and-meta-analysis
#3
Nan Lin, Qing Liu, Xiaoyu Wang, Jianmei Ma, Yuyuan Li
: Backgroud: Neuromyelitis optica (NMO) is an autoimmune inflammatory disorder, which is characterized by severe attacks of optic neuritis and myelitis. Antibodies (Ab) to aquaporin-4 (AQP4) (or NMO-IgG) as a serological biomarker of NMO have been widespread used. Nevertheless, some NMO patients remain seronegative for AQP4-Ab and/or have no detected optic nerve involvement. In addition, no consensus exists on the association between AQP4-Ab serostatus and visual outcome in NMO. To drive a more precise estimate of this postulated relationship, a meta-analysis was performed based on existing relevant studies...
January 10, 2017: Protein and Peptide Letters
https://www.readbyqxmd.com/read/28062213/anti-fibrotic-effects-of-bone-morphogenetic-protein-7-modified-bone-marrow-mesenchymal-stem-cells-on-silica-induced-pulmonary-fibrosis
#4
Xiaoli Li, Guoliang An, Yan Wang, Di Liang, Zhonghui Zhu, Ximeng Lian, Piye Niu, Caixia Guo, Lin Tian
Silicosis is an occupational lung disease caused by exposure to small particles of crystalline silica, which ultimately results in diffuse pulmonary fibrosis. Evidence indicates an anti-fibrotic role of bone morphogenetic protein-7 (BMP-7) and bone marrow mesenchymal stem cells (BMSCs) in lung diseases. Therefore, strategies incorporating genetic engineering and stem cell biology might have a tremendous potential to treat critical injuries and diseases. Therefore, we modified BMSCs to overexpress the BMP-7 gene (BMP-7-BMSCs) by lentivirus transduction, and then evaluated whether fibrotic processes were inhibited by these cells in vivo...
January 4, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28054299/gastric-plication-improves-glycemia-partly-by-restoring-the-altered-expression-of-aquaglyceroporins-in-adipose-tissue-and-the-liver-in-obese-rats
#5
Leire Méndez-Giménez, Sara Becerril, Rafael Moncada, Víctor Valentí, Secundino Fernández, Beatriz Ramírez, Victoria Catalán, Javier Gómez-Ambrosi, Graça Soveral, María M Malagón, Carlos Diéguez, Amaia Rodríguez, Gema Frühbeck
BACKGROUND: Gastric plication is a minimally invasive bariatric surgical procedure, where the greater curvature is plicated inside the gastric lumen. Our aims were to analyze the effectiveness of gastric plication on the resolution of obesity, impaired glucose tolerance, and fatty liver in an experimental model of diet-induced obesity (DIO) and to evaluate changes in glycerol metabolism, a key substrate for adiposity and gluconeogenesis, in adipose tissue and the liver. METHODS: Male Wistar DIO rats (n = 58) were subjected to surgical (sham operation and gastric plication) or dietary interventions [fed a normal diet (ND) or high-fat diet (HFD) or pair-fed to the amount of food eaten by gastric-plicated animals]...
January 4, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28043347/associations-of-hypoosmotic-swelling-test-relative-sperm-volume-shift-aquaporin7-mrna-abundance-and-bull-fertility-estimates
#6
R K Kasimanickam, V R Kasimanickam, A Arangasamy, J P Kastelic
Mammalian sperm are exposed to a natural hypoosmotic environment during male-to-female reproductive tract transition; although this activates sperm motility in vivo, excessive swelling can harm sperm structure and function. Aquaporins (AQPs) is a family of membrane-channel proteins implicated in sperm osmoregulation. The objective was to determine associations among relative sperm volume shift, hypoosmotic swelling test (HOST), sperm aquaporin (AQP) 7 mRNA abundances, and sire conception rate (SCR; fertility estimate) in Holstein bulls at a commercial artificial insemination center...
February 2017: Theriogenology
https://www.readbyqxmd.com/read/28042826/aquaporin-mediated-water-and-hydrogen-peroxide-transport-is-involved-in-normal-human-spermatozoa-functioning
#7
Umberto Laforenza, Giorgia Pellavio, Anna Lisa Marchetti, Claudia Omes, Federica Todaro, Giulia Gastaldi
Different aquaporins (AQPs) are expressed in human sperm cells and with a different localization. Their function has been related to cell volume control in response to the osmotic changes encountered passing from the epididymal fluid to the cervical mucus or involved in the end stage of cytoplasm removal during sperm maturation. Recently, AQPs have also shown hydrogen peroxide (H₂O₂) permeability properties. Here, we investigate the expression, localization and functioning of AQPs in human sperm cells with particular attention to their role as peroxiporins in reactive oxygen species (ROS) scavenging in both normospermic and sub-fertile human subjects...
December 30, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28041790/impairment-of-microvascular-angiogenesis-is-associated-with-delay-in-prostatic-development-in-rat-offspring-of-maternal-protein-malnutrition
#8
Ketlin T Colombelli, Sérgio A A Santos, Ana C L Camargo, Flávia B Constantino, Caroline N Barquilha, Jaqueline C Rinaldi, Sérgio L Felisbino, Luis A Justulin
Experimental data demonstrated the negative impact of maternal protein malnutrition (MPM) on rat prostate development, but the mechanism behind the impairment of prostate growth has not been well understood. Male Sprague Dawley rats, borned to dams fed a normal protein diet (CTR group, 17% protein diet), were compared with those borned from dams fed a low protein diet (6% protein diet) during gestation (GLP group) or gestation and lactation (GLLP). The ventral prostate lobes (VP) were removed at post-natal day (PND) 10 and 21, and analyzed via different methods...
December 29, 2016: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28036023/aquaporins-in-brain-edema-and-neuropathological-conditions
#9
REVIEW
Aristotelis S Filippidis, Richard B Carozza, Harold L Rekate
The aquaporin (AQP) family of water channels are a group of small, membrane-spanning proteins that are vital for the rapid transport of water across the plasma membrane. These proteins are widely expressed, from tissues such as the renal epithelium and erythrocytes to the various cells of the central nervous system. This review will elucidate the basic structure and distribution of aquaporins and discuss the role of aquaporins in various neuropathologies. AQP1 and AQP4, the two primary aquaporin molecules of the central nervous system, regulate brain water and CSF movement and contribute to cytotoxic and vasogenic edema, where they control the size of the intracellular and extracellular fluid volumes, respectively...
December 28, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28034679/the-diapause-program-impacts-renal-excretion-and-molecular-expression-of-aquaporins-in-the-northern-house-mosquito-culex-pipiens
#10
Liu Yang, David L Denlinger, Peter M Piermarini
Adult females of the mosquito Culex pipiens entering diapause increase sugar water ingestion and reduce evaporative water loss, but how these attributes of the diapause program impact activity of the renal excretory system remains unknown. Here we compared the renal excretory capacity of diapausing and non-diapausing females, as well as the molecular expression of aquaporin (AQP) genes that encode channels involved in transporting water and/or small metabolites. Baseline urine excretion rates in diapausing mosquitoes were higher than in those of their non-diapausing counterparts, possibly a consequence of the intense sugar feeding associated with diapause...
December 27, 2016: Journal of Insect Physiology
https://www.readbyqxmd.com/read/28025487/indoxyl-sulfate-as-a-mediator-involved-in-dysregulation-of-pulmonary-aquaporin-5-in-acute-lung-injury-caused-by-acute-kidney-injury
#11
Nozomi Yabuuchi, Masataka Sagata, Chika Saigo, Go Yoneda, Yuko Yamamoto, Yui Nomura, Kazuhiko Nishi, Rika Fujino, Hirofumi Jono, Hideyuki Saito
High mortality of acute kidney injury (AKI) is associated with acute lung injury (ALI), which is a typical complication of AKI. Although it is suggested that dysregulation of lung salt and water channels following AKI plays a pivotal role in ALI, the mechanism of its dysregulation has not been elucidated. Here, we examined the involvement of a typical oxidative stress-inducing uremic toxin, indoxyl sulfate (IS), in the dysregulation of the pulmonary predominant water channel, aquaporin 5 (AQP-5), in bilateral nephrectomy (BNx)-induced AKI model rats...
December 23, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28024836/effects-of-testosterone-on-mean-arterial-pressure-and-aquaporin-aqp-1-2-3-4-6-and-7-expressions-in-the-kidney-of-orchidectomized-adult-male-sprague-dawley-rats
#12
Su Yi Loh, Nelli Giribabu, Khadijeh Gholami, Naguib Salleh
: We hypothesized that higher blood pressure in males than females could be due to testosterone effects on aquaporin (AQP) expression in kidneys. METHODS: Orchidectomized adult male Sprague-Dawley (SD) rats received seven days subcutaneous testosterone treatment (125 μg/kg/day or 250 μg/kg/day), with or without flutamide or finasteride. Following completion of treatment, MAP was determined in rats under anaesthesia via carotid artery cannulation. In another cohort of rats, kidneys were removed following sacrifice and AQP-1, 2, 3, 4, 6 and 7 protein and mRNA levels were determined by Western blotting and Real-time PCR respectively...
January 15, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28004290/quantitative-analysis-of-aquaporin-expression-levels-during-the-development-and-maturation-of-the-inner-ear
#13
Takushi Miyoshi, Taro Yamaguchi, Kiyokazu Ogita, Yasuko Tanaka, Ken-Ichi Ishibashi, Hiroaki Ito, Taisuke Kobayashi, Takayuki Nakagawa, Juichi Ito, Koichi Omori, Norio Yamamoto
Aquaporins (AQPs) are a family of small membrane proteins that transport water molecules across the plasma membrane along the osmotic gradient. Mammals express 13 subtypes of AQPs, including the recently reported "subcellular AQPs", AQP11 and 12. Each organ expresses specific subsets of AQP subtypes, and in the inner ear, AQPs are essential for the establishment and maintenance of two distinct fluids, endolymph and perilymph. To evaluate the contribution of AQPs during the establishment of inner ear function, we used quantitative reverse transcription polymerase chain reaction to quantify the expression levels of all known AQPs during the entire development and maturation of the inner ear...
December 21, 2016: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/28003847/in-vitro-protective-effect-of-phikud-navakot-extraction-on-erythrocyte
#14
Kanchana Kengkoom, Sumate Ampawong
Phikud Navakot (PN), Thai herbal remedy in National List of Essential Medicines, has been claimed to reduce many cardiovascular symptoms especially dizziness and fainting. Apart from blood supply, erythrocyte morphology, in both shape and size, is one of the main consideration factors in cardiovascular diseases and may be affected by vascular oxidative stress. However, little is known about antioxidative property of PN on erythrocyte to preserve red blood cell integrity. In this study, 1,000 μM hydrogen peroxide-induced oxidative stress was conducted on sheep erythrocyte...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27983600/rat-aquaporin-5-is-ph-gated-induced-by-phosphorylation-and-is-implicated-in-oxidative-stress
#15
Claudia Rodrigues, Andreia Filipa Mósca, Ana Paula Martins, Tatiana Nobre, Catarina Prista, Fernando Antunes, Ana Cipak Gasparovic, Graça Soveral
Aquaporin-5 (AQP5) is a membrane water channel widely distributed in human tissues that was found up-regulated in different tumors and considered implicated in carcinogenesis in different organs and systems. Despite its wide distribution pattern and physiological importance, AQP5 short-term regulation was not reported and mechanisms underlying its involvement in cancer are not well defined. In this work, we expressed rat AQP5 in yeast and investigated mechanisms of gating, as well as AQP5's ability to facilitate H₂O₂ plasma membrane diffusion...
December 13, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27978530/aquaporin-water-channels-and-hydrocephalus
#16
Alan S Verkman, Lukmanee Tradtrantip, Alex J Smith, Xiaoming Yao
The aquaporins (AQPs) are a family of water-transporting proteins that are broadly expressed in mammalian cells. Two AQPs in the central nervous system, AQP1 and AQP4, might play a role in hydrocephalus and are thus potential drug targets. AQP1 is expressed in the ventricular-facing membrane of choroid plexus epithelial cells, where it facilitates the secretion of cerebrospinal fluid (CSF). AQP4 is expressed in astrocyte foot processes and ependymal cells lining ventricles, where it appears to facilitate the transport of excess water out of the brain...
December 16, 2016: Pediatric Neurosurgery
https://www.readbyqxmd.com/read/27965700/genome-wide-analysis-of-the-aquaporin-gene-family-in-chickpea-cicer-arietinum-l
#17
Amit A Deokar, Bunyamin Tar'an
Aquaporins (AQPs) are essential membrane proteins that play critical role in the transport of water and many other solutes across cell membranes. In this study, a comprehensive genome-wide analysis identified 40 AQP genes in chickpea (Cicer arietinum L.). A complete overview of the chickpea AQP (CaAQP) gene family is presented, including their chromosomal locations, gene structure, phylogeny, gene duplication, conserved functional motifs, gene expression, and conserved promoter motifs. To understand AQP's evolution, a comparative analysis of chickpea AQPs with AQP orthologs from soybean, Medicago, common bean, and Arabidopsis was performed...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27941618/aquaporins-in-the-spinal-cord
#18
REVIEW
Michal K Oklinski, Mariusz T Skowronski, Agnieszka Skowronska, Michael Rützler, Kirsten Nørgaard, John D Nieland, Tae-Hwan Kwon, Søren Nielsen
Aquaporins (AQPs) are water channel proteins robustly expressed in the central nervous system (CNS). A number of previous studies described the cellular expression sites and investigated their major roles and function in the brain and spinal cord. Among thirteen different mammalian AQPs, AQP1 and AQP4 have been mainly studied in the CNS and evidence has been presented that they play important roles in the pathogenesis of CNS injury, edema and multiple diseases such as multiple sclerosis, neuromyelitis optica spectrum disorders, amyotrophic lateral sclerosis, glioblastoma multiforme, Alzheimer's disease and Parkinson's disease...
December 7, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27935978/genome-wide-identification-phylogeny-and-expression-of-aquaporin-genes-in-common-carp-cyprinus-carpio
#19
Chuanju Dong, Lin Chen, Jingyan Feng, Jian Xu, Shahid Mahboob, Khalid Al-Ghanim, Xuejun Li, Peng Xu
BACKGROUND: Aquaporins (Aqps) are integral membrane proteins that facilitate the transport of water and small solutes across cell membranes. Among vertebrate species, Aqps are highly conserved in both gene structure and amino acid sequence. These proteins are vital for maintaining water homeostasis in living organisms, especially for aquatic animals such as teleost fish. Studies on teleost Aqps are mainly limited to several model species with diploid genomes. Common carp, which has a tetraploidized genome, is one of the most common aquaculture species being adapted to a wide range of aquatic environments...
2016: PloS One
https://www.readbyqxmd.com/read/27921242/human-mesenchymal-stem-cells-from-adipose-tissue-differentiated-into-neuronal-or-glial-phenotype-express-different-aquaporins
#20
Rosanna Avola, Adriana Carol Eleonora Graziano, Giovanna Pannuzzo, Venera Cardile
Aquaporins (AQPs) are 13 integral membrane proteins that provide selective pores for the rapid movement of water and other uncharged solutes, across cell membranes. Recently, AQPs have been focused for their role in production, circulation, and homeostasis of the cerebrospinal fluid and their importance in several human diseases is becoming clear. This study investigated the time course (0, 14, and 28 days) of AQP1, 4, 7, 8, and 9 during the neural differentiation of human mesenchymal stem cells (MSCs) from adipose tissue (AT)...
December 5, 2016: Molecular Neurobiology
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