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https://www.readbyqxmd.com/read/27921242/human-mesenchymal-stem-cells-from-adipose-tissue-differentiated-into-neuronal-or-glial-phenotype-express-different-aquaporins
#1
Rosanna Avola, Adriana Carol Eleonora Graziano, Giovanna Pannuzzo, Venera Cardile
Aquaporins (AQPs) are 13 integral membrane proteins that provide selective pores for the rapid movement of water and other uncharged solutes, across cell membranes. Recently, AQPs have been focused for their role in production, circulation, and homeostasis of the cerebrospinal fluid and their importance in several human diseases is becoming clear. This study investigated the time course (0, 14, and 28 days) of AQP1, 4, 7, 8, and 9 during the neural differentiation of human mesenchymal stem cells (MSCs) from adipose tissue (AT)...
December 5, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27905992/variable-sensitivity-to-complement-dependent-cytotoxicity-in-murine-models-of-neuromyelitis-optica
#2
Yiting Liu, Danielle E Harlow, Katherine S Given, Gregory P Owens, Wendy B Macklin, Jeffrey L Bennett
BACKGROUND: Studies of neuromyelitis optica (NMO), an autoimmune disease of the central nervous system (CNS), have demonstrated that autoantibodies against the water channel aquaporin-4 (AQP4) induce astrocyte damage through complement-dependent cytotoxicity (CDC). In developing experimental models of NMO using cells, tissues or animals from mice, co-administration of AQP4-IgG and normal human serum, which serves as the source of human complement (HC), is required. The sensitivity of mouse CNS cells to HC and CDC in these models is not known...
December 1, 2016: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/27891097/molecular-characterization-of-aquaporin-1-and-aquaporin-3-from-the-gills-of-the-african-lungfish-protopterus-annectens-and-changes-in-their-branchial-mrna-expression-levels-and-protein-abundance-during-three-phases-of-aestivation
#3
You R Chng, Jasmine L Y Ong, Biyun Ching, Xiu L Chen, Kum C Hiong, Wai P Wong, Shit F Chew, Siew H Lam, Yuen K Ip
African lungfishes can undergo long periods of aestivation on land during drought. During aestivation, lungfishes are confronted with desiccation and dehydration, and their gills become non-functional and covered with a thick layer of dried mucus. Aquaporins (Aqps) are a superfamily of integral membrane proteins which generally facilitate the permeation of water through plasma membranes. This study aimed to obtain the complete cDNA coding sequences of aqp1 and aqp3 from the gills of Protopterus annectens, and to determine their branchial mRNA and protein expression levels during the induction, maintenance and arousal phases of aestivation...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27882156/clinical-effects-of-joint-application-of-%C3%AE-sodium-aescinate-and-mannitol-in-treating-early-swelling-after-upper-limb-trauma-surgery
#4
Bin Wang, Ruixiang Yang, Qing Ju, Shaofeng Liu, Yongchun Zhang, Yong Ma
The aim of the present study was to examine the clinical merits of joint application of β-sodium aescinate and mannitol for the treatment of early swelling of upper limb trauma after surgery. We verified whether the expression of serum aquaporin 1 (AQP-1) was involved in swelling mechanism. A total of 102 patients with swelling after upper limb trauma surgery were enrolled into the study and divided randomly into 3 groups (n=34 cases per group). Group A was treated with β-sodium aescinate; group B was treated with with mannitol and group C was treated with both β-sodium aescinate and mannitol...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27881985/pollen-aquaporins-the-solute-factor
#5
REVIEW
Juliana A Pérez Di Giorgio, Gabriela C Soto, Jorge P Muschietti, Gabriela Amodeo
In the recent years, the biophysical properties and presumed physiological role of aquaporins (AQPs) have been expanded to specialized cells where water and solute exchange are crucial traits. Complex but unique processes such as stomatal movement or pollen hydration and germination have been addressed not only by identifying the specific AQP involved but also by studying how these proteins integrate and coordinate cellular activities and functions. In this review, we referred specifically to pollen-specific AQPs and analyzed what has been assumed in terms of transport properties and what has been found in terms of their physiological role...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27860388/enhanced-tissue-remodeling-efficacy-of-adipose-derived-mesenchymal-stem-cells-using-injectable-matrices-in-radiation-damaged-salivary-gland-model
#6
Jeong-Seok Choi, Hye-Young An, Hyun-Soo Shin, Young-Mo Kim, Jae-Yol Lim
The present study was conducted to introduce the use of a delivery carrier for local transplantation of human adipose tissue-derived mesenchymal stem cells (AdMSCs) into the salivary gland (SG) and analyze its ability to enhance radioprotection of AdMSCs against irradiation (IR)-induced damage. An injectable porcine small intestinal submucosa (SIS) matrix was used as a cell delivery carrier and human AdMSCs were contained within SIS hydrogel (AdMSC/SIS). After local injection into SGs of mice following local IR, morphological and functional changes were evaluated in the sham, vehicle (PBS), SIS, AdMSC, and AdMSC/SIS groups...
November 12, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27835672/the-expression-of-water-and-ion-channels-in-diffuse-alveolar-damage-is-not-dependent-on-dad-etiology
#7
Ruy Camargo Pires-Neto, Fabiola Del Carlo Bernardi, Priscila Alves de Araujo, Thais Mauad, Marisa Dolhnikoff
INTRODUCTION: Aquaporins and ion channels are membrane proteins that facilitate the rapid movement of water and solutes across biological membranes. Experimental and in vitro studies reported that the function of these channels and pulmonary edema resolution are impaired in acute lung injury (ALI). Although current evidence indicates that alveolar fluid clearance is impaired in patients with ALI/diffuse alveolar damage (DAD), few human studies have addressed the alterations in pulmonary channels in this clinical condition...
2016: PloS One
https://www.readbyqxmd.com/read/27833554/n-butylphthalide-alleviates-blood-brain-barrier-impairment-in-rats-exposed-to-carbon-monoxide
#8
Mingjun Bi, Mingwei Zhang, Dadong Guo, Weikang Bi, Bin Liu, Yong Zou, Qin Li
Carbon monoxide (CO) poisoning is one of the most important health concerns and may result in neuropathologic changes and neurologic sequelae. However, few studies have addressed the correlation between CO poisoning and blood-brain barrier (BBB) impairment. In this study, we investigated the effects of N-butylphthalide (NBP) on the expressions of zonula occludens-1 (ZO-1), claudin-5 and aquaporin-4 (AQP-4) proteins in a CO poisoning rat model. The results indicated that the brain water content was obviously increased, and the tight junctions between endothelial cells were disrupted, resulting in significant cerebral edema and BBB dysfunction in a rat model of CO poisoning...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27818669/soybean-tip-gene-family-analysis-and-characterization-of-gmtip1-5-and-gmtip2-5-water-transport-activity
#9
Li Song, Na Nguyen, Rupesh K Deshmukh, Gunvant B Patil, Silvas J Prince, Babu Valliyodan, Raymond Mutava, Sharon M Pike, Walter Gassmann, Henry T Nguyen
Soybean, one of the most important crops worldwide, is severely affected by abiotic stress. Drought and flooding are the major abiotic stresses impacting soybean yield. In this regard, understanding water uptake by plants, its utilization and transport has great importance. In plants, water transport is mainly governed by channel forming aquaporin proteins (AQPs). Tonoplast intrinsic proteins (TIPs) belong to the plant-specific AQP subfamily and are known to have a role in abiotic stress tolerance. In this study, 23 soybean TIP genes were identified based on the latest soybean genome annotation...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27817092/comparisons-of-presentations-and-outcomes-of-neuromyelitis-optica-patients-with-and-without-sj%C3%A3-gren-s-syndrome
#10
Yu Hua Zhong, Zhi Gang Zhong, Zhou Zhou, Zhen Yu Ma, Meng Yao Qiu, Fu Hua Peng, Wei Xi Zhang
Patients with neuromyelitis optica (NMO) often have an accompanying autoimmune disease, most commonly, but not limited to Sjögren's syndrome (SS). The aim of this study was to compare clinical and laboratory features between NMO patients with and without SS and to investigate the prognosis of NMO in patients with and without SS. Twenty-three NMO patients with SS and 42 NMO patients without SS were included. Clinical and laboratory profiles were compared, including annual relapse rate and time from onset of NMO to Expanded Disability Status Scale (EDSS) scores of 4...
November 5, 2016: Neurological Sciences
https://www.readbyqxmd.com/read/27817002/overexpression-of-aquaporin-1-is-a-prognostic-factor-for-biochemical-recurrence-in-prostate-adenocarcinoma
#11
Ji Y Park, GhilSuk Yoon
Aquaporins (AQP) are transmembrane proteins that provide channels for water and solutes, and some are involved in tumor progression and invasion. We evaluated the expression of AQP-1, AQP-3, and AQP-5 and their clinicopathological significance in prostate adenocarcinomas (PCA). Prostatectomy specimens (n = 99) were retrieved from the surgical pathology archives and clinicopathological data were obtained from the medical database at Kyungpook National University Hospital. Immunohistochemical staining for AQP-1, AQP-3, and AQP-5 was performed on tissue microarrays comprising paired malignant and benign prostatic tissues...
November 5, 2016: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/27804234/chitosan-promotes-aquaporin-formation-and-inhibits-mucociliary-differentiation-of-nasal-epithelial-cells-through-increased-tgf-%C3%AE-1-production
#12
Tsung-Wei Huang, Ching-Kuo Wei, Huang-Wei Su, Kai-Min Fang
Although endoscopic sinus surgery is the mainstay surgical treatment for chronic rhinosinusitis, over 15% of patients require a repeat operation wherein postoperative adhesion formation is one of the main causes of failure. Several recently proposed chitosan-based biomaterials promote mucosal healing, reduce postoperative adhesion formation and restore mucociliary function of sinonasal mucosa. However, the effects of chitosan on cellular morphology, re-epithelization, and mucociliary differentiation of nasal epithelial cells (NECs) during the wound healing process have not been thoroughly investigated...
November 2, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27779640/aquaporin-1-contributes-to-chondrocyte-apoptosis-in-a-rat-model-of-osteoarthritis
#13
Hangfei Gao, Jiancao Gui, Liming Wang, Yan Xu, Yiqiu Jiang, Mingyue Xiong, Yongguang Cui
Aquaporins (AQPs) have been found to be associated with a number of diseases. However, the role of AQP‑1 in the pathogenesis of osteoarthritis remains unclear. We previously found that AQP‑1 expression was upregulated in osteoarthritic cartilage and strongly correlated with caspase‑3 expression and activity. The aim of this study was to further investigate the association of AQP‑1 expression with chondrocyte apoptosis in a rat model of osteoarthritis, using RNA interference to knock down AQP‑1. For this purspose, 72 male Sprague‑Dawley rats were randomly assigned to 3 groups as follows: the control group not treated surgically (n=24), the sham‑operated group (n=24), and the osteoarthritis group (n=24)...
October 24, 2016: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/27777930/characterization-of-aqps-in-mouse-rat-and-human-colon-and-their-selective-regulation-by-bile-acids
#14
Jonathan Yde, Stephen Keely, Qi Wu, Johan F Borg, Natalia Lajczak, Aoife O'Dwyer, Peter Dalsgaard, Robert A Fenton, Hanne B Moeller
In normal individuals, the epithelium of the colon absorbs 1.5-2 l of water a day to generate dehydrated feces. However, in the condition of bile acid malabsorption (BAM), an excess of bile acids in the colon results in diarrhea. Several studies have attempted to address the mechanisms contributing to BAM induced by various bile acids. However, none have addressed a potential dysregulation of aquaporin (AQP) water channels, which are responsible for the majority of transcellular water transport in epithelial cells, as a contributing factor to the onset of diarrhea and the pathogenesis of BAM...
2016: Frontiers in Nutrition
https://www.readbyqxmd.com/read/27773635/molecular-expression-of-aquaporin-mrnas-in-the-northern-house-mosquito-culex-pipiens
#15
Liu Yang, Peter M Piermarini
Aquaporins (AQPs) are a family of membrane-bound proteins, originally described as water-channels, that broadly exist in prokaryotic and eukaryotic cells. However, some AQPs can transport small molecules (e.g. urea, glycerol) along with or preferentially to water. Previous work in the mosquitoes Aedes aegypti and Anopheles gambiae have characterized the molecular expression of one or more AQP genes and shown that they are involved in water homeostasis after blood feeding, tolerance to dehydration and heat stresses, and development of Plasmodium falciparum in the mosquito...
October 20, 2016: Journal of Insect Physiology
https://www.readbyqxmd.com/read/27763558/involvement-of-jnk-nf%C3%AE%C2%BAb-signaling-pathways-in-the-lipopolysaccharide-induced-modulation-of-aquaglyceroporin-expression-in-3t3-l1-cells-differentiated-into-adipocytes
#16
Jeanne Durendale Chiadak, Tatjana Arsenijevic, Francoise Gregoire, Nargis Bolaky, Valerie Delforge, Jason Perret, Christine Delporte
Aquaglyceroporins, belonging to the family of aquaporins (AQPs), are integral plasma membrane proteins permeable to water and glycerol that have emerged as key players in obesity. The aim of this study was to investigate the expression profile of AQPs in undifferentiated and differentiated 3T3-L1 cells and to investigate the changes in expression of aquaglyceroporins in 3T3-L1 cells differentiated into adipocytes and subjected to lipopolysaccharide (LPS) mimicking inflammation occurring during obesity. Furthermore, the study aimed at identifying the signaling cascade involved in the regulation of aquaglyceroporins expression upon LPS stimulation...
October 18, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27754715/the-extracellular-c-loop-domain-plays-an-important-role-in-the-cell-adhesion-function-of-aquaporin-0
#17
Yosuke Nakazawa, Mikako Oka, Megumi Funakoshi-Tago, Hiroomi Tamura, Makoto Takehana
PURPOSE: Although aquaporin 0 (AQP0) is a member of the AQP family, it has limited water permeability compared with other members. AQP0 may also have cell adhesion-related functions, but the evidence is still limited. Here, we studied the relationship of AQP0 to cell adhesion and determined the region required for cell adhesion. METHODS: L-cell fibroblasts stably expressing AQP0 or AQP1 (L-AQP0 or L-AQP1) were established. One group of cells was stained with CellTracker Red and cultured into a confluent monolayer, whereas the other group was loaded with CellTracker Blue and seeded over the monolayer...
October 18, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27754576/overexpression-of-msdreb6-2-results-in-cytokinin-deficient-developmental-phenotypes-and-enhances-drought-tolerance-in-transgenic-apple-plants
#18
Xiong Liao, Xiao Guo, Qi Wang, Yantao Wang, Di Zhao, Liping Yao, Shuang Wang, Guojie Liu, Tianhong Li
Dehydration-responsive element binding factors (DREBs) play important roles in plant growth, development, and stress signaling pathways in model plants. However, little is known about the function of DREBs in apple (Malus × domestica), a widely cultivated crop that is frequently threatened by drought. We isolated a DREB gene from Malus sieversii (Ledeb.) Roem., MsDREB6.2, and investigated its functions using overexpression analysis and chimeric repressor gene-silencing technology (CRES-T). We identified possible target genes of the protein encoded by MsDREB6...
October 18, 2016: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/27746040/expression-of-aquaporin-7-and-aquaporin-9-in-tanycyte-cells-and-choroid-plexus-during-mouse-estrus-cycle
#19
A Yaba, B Sozen, B Suzen, N Demir
Tanycytes are special ependymal cells located in the ventrolateral wall and floor of the third ventricle having processes extending nuclei that regulate reproductive functions and around of vessels in median eminance. The aquaporins (AQPs) are a family of transmembrane proteins that transport water and glycerol. AQP-7 and -9 are permeable to other small molecules as glycerol and therefore called aquaglyceroporins. In this study, we aimed to show localization of AQP-7 and -9 in epithelial cells of choroid plexus and tanycytes during female mouse estrus cycle...
October 13, 2016: Morphologie: Bulletin de L'Association des Anatomistes
https://www.readbyqxmd.com/read/27725883/clinical-features-and-visual-outcomes-of-optic-neuritis-in-chinese-children
#20
Huanfen Zhou, Wei Wang, Quangang Xu, Shaoying Tan, Shuo Zhao, Mo Yang, Chunxia Peng, Shihui Wei
Purpose. Although optic neuritis (ON) in children is relatively common, visual outcomes and factors associated with the condition have not been well documented. The aim of this study was to evaluate the clinical features and visual outcomes of ON in Chinese children. Methods. Patients with a first episode of ON at a tertiary neuroophthalmic centre in China were assessed and followed up for at least three months. Visual outcomes and clinical, laboratory, and neuroimaging findings were reviewed. In patients with bilateral ON, only the eyes with worse visual acuity (VA) at presentation were used for statistical analysis...
2016: Journal of Ophthalmology
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