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https://www.readbyqxmd.com/read/29330527/aquaglyceroporin-pbaqp-is-required-for-efficient-progression-through-the-liver-stage-of-plasmodium-infection
#1
Dominique Promeneur, Godfree Mlambo, Peter Agre, Isabelle Coppens
The discovery of aquaglyceroporins (AQP) has highlighted a new mechanism of membrane solute transport that may hold therapeutic potential for controlling parasitic infections, including malaria. Plasmodium parasites express a single AQP at the plasma membrane that functions as a channel for water, nutrients and waste into and out cells. We previously demonstrated that Plasmodium berghei targeted for PbAQP deletion are deficient in glycerol import and less virulent than wild-type parasites during the blood developmental stage...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29322818/evolution-of-ph-buffers-and-water-homeostasis-in-eukaryotes-homology-between-humans-and-acanthamoeba-proteins
#2
Abdul M Baig, R Zohaib, S Tariq, H R Ahmad
AIM: This study intended to trace the evolution of acid-base buffers and water homeostasis in eukaryotes. Acanthamoeba castellanii  was selected as a model unicellular eukaryote for this purpose. Homologies of proteins involved in pH and water regulatory mechanisms at cellular levels were compared between humans and A. castellanii. MATERIALS & METHODS: Amino acid sequence homology, structural homology, 3D modeling and docking prediction were done to show the extent of similarities between carbonic anhydrase 1 (CA1), aquaporin (AQP), band-3 protein and H+ pump...
January 11, 2018: Future Microbiology
https://www.readbyqxmd.com/read/29322789/rna-interference-mediated-silencing-of-aquaporin-aqp-5-hinders-angiogenesis-of-colorectal-tumor-by-suppressing-the-production-of-vascular-endothelial-growth-factor
#3
W Wang, Q Li, T Yang, D Li, F Ding, H Sun, G Bai
Aquaporin (AQP)-5 is an essential member of AQP family involved in the tumorigenesis of various malignant tumors. However, its role in the angiogenesis of colorectal cancer is unclear and requires further investigation. In this study, a pRNA-H1.1 vector containing the short hairpin RNA (shRNA) targeting AQP5 mRNA was constructed to inhibit the endogenous expression of AQP5 in human umbilical vein endothelial cells (HUVECs). We found that the AQP5-silenced HUVECs acquired decreased proliferation, migration and tube formation ability...
2018: Neoplasma
https://www.readbyqxmd.com/read/29321959/daily-voluntary-exercise-enhances-pilocarpine-induced-saliva-secretion-and-aquaporin-1-expression-in-rat-submandibular-glands
#4
Kentaro Matsuzaki, Naotoshi Sugimoto, Masanori Katakura, Eri Sumiyoshi, Toshiko Hara, Michio Hashimoto, Osamu Shido
Saliva-a water-based fluid containing electrolytes, immunoglobulins, and enzymes-has many functions, including the protection and hydration of mucosal structures within the oral cavity and the initiation of digestion. Aquaporins (AQPs) are proteins that act as water channels through membranes. We have previously reported upregulation of the expression levels of AQP 1 and 5 in the submandibular glands (SMGs) in heat-acclimated rats. In this study, we investigated pilocarpine-induced saliva secretion and AQP expression in rats after voluntary exercise...
January 2018: FEBS Open Bio
https://www.readbyqxmd.com/read/29303600/aquaporin-expression-in-the-fetal-porcine-urinary-tract-changes-during-gestation
#5
L K Jakobsen, K Trelborg, P S Kingo, S Hoyer, K-E Andersson, J C Djurhuus, R Norregaard, L H Olsen
The expression of aquaporins (AQPs) in the fetal porcine urinary tract and its relation to gestational age has not been established. Tissue samples from the renal pelvis, ureter, bladder and urethra were obtained from porcine fetuses. Samples were examined by RT-PCR (AQPs 1-11), QPCR (AQPs positive on RT-PCR), and immunohistochemistry. Bladder samples were additionally examined by Western blotting. RNA was extracted from 76 tissue samples obtained from 19 fetuses. Gestational age was 60 (n=11) or 100 days (n=8)...
January 5, 2018: Physiological Research
https://www.readbyqxmd.com/read/29301341/endothelial-aquaporins-and-hypomethylation-potential-implications-for-atherosclerosis-and-cardiovascular-disease
#6
Inês Vieira da Silva, Madalena Barroso, Teresa Moura, Rita Castro, Graça Soveral
Aquaporins (AQPs) are transmembrane channels that facilitate water and glycerol permeation through cell membranes. Recently, the water channel AQP1 was suggested to contribute to endothelial homeostasis and cardiovascular health. Less is known about endothelial aquaglyceroporins expression and its implication in cardiovascular disease (CVD). We have previously used cultured human endothelial cells under a hypomethylating environment to study endothelial dysfunction and activation, a phenotype implicated in the establishment of atherosclerosis and CVD...
January 3, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29288747/magnesium-sulfate-attenuates-brain-edema-by-lowering-aqp4-expression-and-inhibits-glia-mediated-neuroinflammation-in-a-rodent-model-of-eclampsia
#7
Xiaolan Li, Huishu Liu, Yuanyuan Yang
Eclampsia is characterized by high morbidity and mortality wordwide. Magnesium sulfate ( MgSO4 ) is used frequently as a prophylaxis for eclamptic seizure in clinical settings. However, the underlying mechanism is less studied, we have previously demonstrated that MgSO4 pretreatment decreases eclampsia-like seizure threshold. Here, we further evaluated the hypothesis that MgSO4 exert neuroprotective actions in eclampsia-like rats model by ameliorating neuroinflammation and brain edema. In this study, the eclampsia-like model was established by administering lipopolysaccharide plus pentylenetetrazol in pregnant Sprague-Dawley rats...
December 27, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29285152/the-single-nucleotide-polymorphism-site-of-aquaporin-4-gene-in-patients-with-neuromyelitis-optica
#8
Qing-Song Wang, Hong-Qiong Xiao, Hua-Xian Chen, Yan-Ping Liu, Xu-Dong Ding
The single nucleotide polymorphism (SNP) site within the aquaporin (AQP)-4 gene exons and its possible role in the pathogenesis of neuromyelitis optica (NMO) were studied. From March 2010 to June 2012, 72 patients with NMO from Xiangyang No. 1 People's Hospital, Hubei University of Medicine were enrolled in the NMO group. At the same time, 80 patients with multiple sclerosis (MS) were enrolled in our study as the MS group. Blood samples were collected and DNA was extracted for analysis of SNP sites of AQP4 gene...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29285135/omeprazole-preserves-the-rer-in-chief-cells-and-enhances-re-epithelialization-of-parietal-cells-with-sod-and-aqp-4-up-regulation-in-ethanol-induced-gastritis-rats
#9
Kanchana Kengkoom, Napatara Tirawanchai, Wannee Angkhasirisap, Sumate Ampawong
Gastric mucosal cells, particularly parietal and chief cells, are usually affected by exogenous, and endogenous stimuli-induced gastritis. The integrity of these cells and their alterations are involved in the pathogenesis of numerous gastric disorders. Omeprazole, a gastric acid secretion blocker, is commonly used for gastrointestinal diseases due to its antioxidative stress and anti-inflammatory properties. Little is known regarding how omeprazole modulates the re-epithelialized effect on gastric mucosal cells associated with gastrointestinal disorders...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29278770/identification-of-the-aqp-members-involved-in-abiotic-stress-responses-from-arabidopsis
#10
Zhi-Juan Feng, Sheng-Chun Xu, Na Liu, Gu-Wen Zhang, Qi-Zan Hu, Zhao-Shi Xu, Ya-Ming Gong
Aquaporins (AQPs) constitute a highly diverse family of water channel proteins that play crucial biological functions in plant growth and development and stress physiology. In Arabidopsis, 35 AQPs are classified into four subfamilies (PIPs, TIPs, NIPs and SIPs). However, knowledge about the roles of different subfamily AQPs remains limited. Here, we explored the chromosomal location, gene structure and expression patterns of all AQPs in different tissues or under different abiotic stresses based on available microarray data...
December 23, 2017: Gene
https://www.readbyqxmd.com/read/29262394/dachengqi-decoction-attenuates-intestinal-vascular-endothelial-injury-in-severe-acute-pancreatitis-in-vitro-and-in-vivo
#11
Li-Yun Pan, Ya-Feng Chen, Hong-Chang Li, Li-Ming Bi, Wen-Jie Sun, Gui-Fang Sun, Xiao-Fen Zhang, Ke Xu, Dian-Xu Feng
BACKGROUND/AIMS: Dachengqi decoction (DCQD) is a well-known traditional Chinese herbal drug with strong anti-inflammatory effects. Angiopoietin-1 (Ang-1) plays a vital role in maintaining the stability and integrity of the vascular wall and prevents vascular leakage due to inflammatory mediators. Our previous work found that DCQD protects against pancreatic injury in rats with severe acute pancreatitis (SAP). This study aims to investigate the effects of DCQD on intestinal endothelial damage in both damaged human umbilical vein endothelial cells (HUVECs) and SAP rats...
December 18, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29243846/aqp2-can-modulate-the-pattern-of-ca2-transients-induced-by-store-operated-ca2-entry-under-trpv4-activation
#12
Alejandro Pizzoni, Macarena López González, Gisela Di Giusto, Valeria Rivarola, Claudia Capurro, Paula Ford
There is increasing evidence indicating that aquaporins (AQPs) exert an influence in cell signaling by the interplay with the TRPV4 Ca2+ channel. Ca2+ release from intracellular stores and plasma membrane hyperpolarization due to opening of Ca2+ -activated potassium channels (KCa) are events that have been proposed to take place downstream of TRPV4 activation. A major mechanism for Ca2+ entry, activated after depletion of intracellular Ca2+ stores and driven by electrochemical forces, is the store-operated Ca2+ entry (SOCE)...
December 15, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29243390/aquaporin-4-blockade-improves-survival-of-murine-heart-allografts-subjected-to-prolonged-cold-ischemia
#13
Katayoun Ayasoufi, Naoki Kohei, Michael Nicosia, Ran Fan, George W Farr, Paul R McGuirk, Marc F Pelletier, Robert L Fairchild, Anna Valujskikh
Prolonged cold ischemia storage (CIS) is a leading risk factor for poor transplant outcome. Existing strategies strive to minimize IRI in transplanted organs, yet there is a need for novel approaches to improve outcomes of marginal allografts and expand the pool of donor organs suitable for transplantation. Aquaporins (AQPs) are a family of water channels that facilitate homeostasis, tissue injury and inflammation. We tested whether inhibition of AQP4 improves the survival of fully MHC-mismatched murine cardiac allografts subjected to 8 h CIS...
December 15, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/29233707/phylogenetic-characterization-of-transporter-proteins-in-the-cnidarian-dinoflagellate-symbiosis
#14
Ashley E Sproles, Nathan L Kirk, Sheila A Kitchen, Clinton A Oakley, Arthur R Grossman, Virginia M Weis, Simon K Davy
Metabolic exchange between cnidarians and their symbiotic dinoflagellates is central to maintaining their mutualistic relationship. Sugars are translocated to the host, while ammonium and nitrate are utilized by the dinoflagellates (Symbiodinium spp.). We investigated membrane protein sequences of each partner to identify potential transporter proteins that move sugars into cnidarian cells and nitrogen products into Symbiodinium cells. We examined the facilitated glucose transporters (GLUT), sodium/glucose cotransporters (SGLT), and aquaporin (AQP) channels in the cnidarian host as mechanisms for sugar uptake, and the ammonium and high-affinity nitrate transporters (AMT and NRT2, respectively) in the algal symbiont as mechanisms for nitrogen uptake...
December 9, 2017: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/29231874/the-role-of-aquaporins-in-ocular-lens-homeostasis
#15
REVIEW
Kevin L Schey, Rosica S Petrova, Romell B Gletten, Paul J Donaldson
Abstract: Aquaporins (AQPs), by playing essential roles in the maintenance of ocular lens homeostasis, contribute to the establishment and maintenance of the overall optical properties of the lens over many decades of life. Three aquaporins, AQP0, AQP1 and AQP5, each with distinctly different functional properties, are abundantly and differentially expressed in the different regions of the ocular lens. Furthermore, the diversity of AQP functionality is increased in the absence of protein turnover by age-related modifications to lens AQPs that are proposed to alter AQP function in the different regions of the lens...
December 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29223338/molecular-cloning-and-expression-analysis-of-aquaporin-genes-in-pearl-millet-pennisetum-glaucum-l-r-br-genotypes-contrasting-in-their-transpiration-response-to-high-vapour-pressure-deficits
#16
Palakolanu Sudhakar Reddy, Murugesan Tharanya, Kaliamoorthy Sivasakthi, Mallayee Srikanth, C Tom Hash, Jana Kholova, Kiran K Sharma, Vincent Vadez
Pearl millet is a crop of the semi-arid tropics having high degree of genetic diversity and variable tolerance to drought stress. To investigate drought tolerance mechanism that possibly accounts for differences in drought tolerance, four recombinant inbred lines from a high resolution cross (HRC) were selected for variability in their transpiration rate (Tr) response to vapour pressure deficit (VPD) conditions. The differential Tr response of the genotypes to increased VPD conditions was used to classify the genotypes as sensitive or insensitive to high VPD...
December 2017: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/29217817/acetazolamide-suppresses-multi-drug-resistance-related-protein-1-and-p-glycoprotein-expression-by-inhibiting-aquaporins-expression-in-a-mesial-temporal-epilepsy-rat-model
#17
Lei Duan, Qing Di
BACKGROUND Mesial temporal epilepsy (MTLE) is the most common type of focal epilepsy in adults, and is often drug-resistant. This study investigated the effects of aquaporins (AQP) inhibitor on multi-drug-resistant protein expression in an MTLE rat model. MATERIAL AND METHODS The MTLE rat model was established by injecting pilocarpine into rats. The MTLE rats were divided into an MTLE-6 h group, an MTLE-12 h group, and an MTLE-24 h group, together with a normal saline group (NS), to examine the AQP4 expression by using Western blot assay and immunohistochemistry assay...
December 8, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29217107/the-underlying-physiological-basis-of-the-desert-rodent-meriones-shawi-s-survival-to-prolonged-water-deprivation-central-vasopressin-regulation-on-peripheral-kidney-water-channels-aqps-2
#18
A Elgot, O El Hiba, M Belkouch, H Gamrani
Meriones shawi (M. shawi) is a particular semi-desert rodent known by its resistance to long periods of thirst. The aim of the present investigation is to clarify the underlying mechanisms allowing M. shawi to resist to hard conditions of dehydration. For this reason we used two different approaches: i) a morphometric study, which consists in measuring the effect of dehydration on body and kidneys weights as well as the report kidney weight/body weight, ii) By immunohistochemistry, we proceed to study the effect of dehydration on the immunoreactivity of central vasopressin (AVP) and the kidney aquaporin-2 (AQP-2) which is a channel protein that allows water to permeate across cell membranes...
December 4, 2017: Acta Histochemica
https://www.readbyqxmd.com/read/29203835/purification-and-functional-comparison-of-nine-human-aquaporins-produced-in-saccharomyces-cerevisiae-for-the-purpose-of-biophysical-characterization
#19
Frederik Bühring Bjørkskov, Simon Lyngaa Krabbe, Casper Normann Nurup, Julie Winkel Missel, Mariana Spulber, Julie Bomholt, Karen Molbaek, Claus Helix-Nielsen, Kamil Gotfryd, Pontus Gourdon, Per Amstrup Pedersen
The sparse number of high-resolution human membrane protein structures severely restricts our comprehension of molecular physiology and ability to exploit rational drug design. In the search for a standardized, cheap and easily handled human membrane protein production platform, we thoroughly investigated the capacity of S. cerevisiae to deliver high yields of prime quality human AQPs, focusing on poorly characterized members including some previously shown to be difficult to isolate. Exploiting GFP labeled forms we comprehensively optimized production and purification procedures resulting in satisfactory yields of all nine AQP targets...
December 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29201837/expression-of-aquaporin-1-and-4-in-the-choroid-plexus-and-brain-parenchyma-of-kaolin-induced-hydrocephalic-rats
#20
Taehyung Jeon, Ki-Su Park, Seong-Hyun Park, Jeong-Hyun Hwang, Sung Kyoo Hwang
Objective: Aquaporin (AQP) is a recently discovered protein that regulates water homeostasis. The present study examines changes in AQP 1 and 4 in kaolin induced experimental hydrocephalic rats to elucidate the pathophysiology of water homeostasis in the disease. Methods: Hydrocephalus was induced by percutaneous intracisternal injection of kaolin. The brain parenchyma and choroid plexus were obtained at 3, 7, 14 and 30 days after injection. Protein expressions of AQP 1 and 4 were measured by western blot, immunohistochemistry (IHC) and immunofluorescence (IF) stains...
October 2017: Korean Journal of Neurotrauma
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