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https://www.readbyqxmd.com/read/29677595/bioherbicides-current-knowledge-on-weed-control-mechanism
#1
REVIEW
Ramalingam Radhakrishnan, Abdulaziz A Alqarawi, Elsayed Fathi Abd Allah
Weed control is a challenging event during crop cultivation. Integrated management, including the application of bioherbicides, is an emerging method for weed control in sustainable agriculture. Plant extracts, allelochemicals and some microbes are utilized as bioherbicides to control weed populations. Bioherbicides based on plants and microbes inhibit the germination and growth of weeds; however,few studies conducted in weed physiology. This review ascribes the current knowledge of the physiological changes in weeds that occur during the exposure to bioherbicides...
April 17, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29677567/methods-for-assessing-mitochondrial-quality-control-mechanisms-and-cellular-consequences-in-cell-culture
#2
Matthew Redmann, Gloria A Benavides, Willayat Yousuf Wani, Taylor F Berryhill, Xiaosen Ouyang, Michelle S Johnson, Saranya Ravi, Kasturi Mitra, Stephen Barnes, Victor M Darley-Usmar, Jianhua Zhang
Mitochondrial quality is under surveillance by autophagy, the cell recycling process which degrades and removes damaged mitochondria. Inadequate autophagy results in deterioration in mitochondrial quality, bioenergetic dysfunction, and metabolic stress. Here we describe in an integrated work-flow to assess parameters of mitochondrial morphology, function, mtDNA and protein damage, metabolism and autophagy regulation to provide the framework for a practical assessment of mitochondrial quality. This protocol has been tested with cell cultures, is highly reproducible, and is adaptable to studies when cell numbers are limited, and thus will be of interest to researchers studying diverse physiological and pathological phenomena in which decreased mitochondrial quality is a contributory factor...
April 10, 2018: Redox Biology
https://www.readbyqxmd.com/read/29677542/innovative-perception-on-using-tiron-to-modulate-the-hepatotoxicity-induced-by-titanium-dioxide-nanoparticles-in-male-rats
#3
Ashraf Morgan, Marwa A Ibrahim, Mona K Galal, Hanan A Ogaly, Reham M Abd-Elsalam
The extensive application of titanium dioxide nanoparticles (TiO2 NPs) in the food industry arouses a debate regarding the probable risk associated with their use. Several recent studies reported that most nanoparticles (NPs) have adverse actions on the liver. The objective of this study is to examine whether Tiron plays a modulatory role against apoptotic damage induced by TiO2 NPs in rat livers. Forty rats were randomly divided into 4 groups; a control group received phosphate-buffered saline, an intoxicated group received 100 mg/kg/day of TiO2 NPs for 60 days, a treated group received 470 mg/kg/day of Tiron for the last 14 days after TiO2 NPs administration, and a Tiron group received Tiron only as previously mentioned...
April 17, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29677459/hepatoprotective-and-antioxidant-properties-of-the-aqueous-extract-of-olea-europaea-leaves-against-diclofenac-induced-liver-damages-in-mice
#4
Rawya Soussi, Najla Hfaiedh, Fatma Guesmi, Mohsen Sakly, Khémais Ben Rhouma
Historically, olive tree "Olea europaea" is one of the most important fruit trees in Mediterranean countries. Several studies suggest that olive leaf is a significant source of bioactive phenolic compounds compared to olive oil and fruits. This study was undertaken to investigate, the protective effect of the aqueous extract of « Chemlali » olive leaves against diclofenac-induced damages in liver and haematological alterations in swiss albinos mice. For this, twenty-eight mice were divided into four groups: a control group, a diclofenac-treated group (2...
April 20, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29677454/combined-but-not-the-single-administration-of-vitamin-c-and-l-carnitine-ameliorates-cisplatin-induced-gastric-mucosa-damage-in-male-rats
#5
Modinat Adebukola Adefisayo, Wale Johnson Adeyemi, Quadri Kunle Alabi
Although cisplatin is a potent anticancer drug, it instigates oxidative and pro-inflammatory reactions which poses significant and distressing clinical symptoms in patients including nausea and vomiting which is related to damage of the gastric mucosa. This study investigated the effects of vitamin C and/or L-carnitine on cisplatin-induced gastric mucosa damage in rat. The rats were allocated into groups (n=5): a control group received distilled water and treatment groups received cisplatin (CIP) alone, cisplatin followed by vitamin C, L-carnitine or their combination...
April 20, 2018: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/29677193/a-colorimetric-assay-for-vanillin-detection-by-determination-of-the-luminescence-of-o-toluidine-condensates
#6
Jin Zhao, Haixiong Xia, Tingyu Yu, Lu Jin, Xuehua Li, Yinghui Zhang, Liping Shu, Lingwen Zeng, Zhixu He
Vanillin (4-hydroxy-3-methoxybenzaldehyde), a food additive with rich milk flavor, is commonly used in the food, beverage and cosmetic industries. However, excessive consumption of vanillin may cause liver and kidney damage. Therefore, methods for detecting and controlling the level of vanillin in food, especially in infant powder, have important practical significance. In this study, we established a colorimetric assay for vanillin detection. The detection was performed under high-temperature and acidic conditions, which can induce the reaction of the aldehyde group of vanillin with the amino group of o-toluidine...
2018: PloS One
https://www.readbyqxmd.com/read/29677080/corm-401-reduces-ischemia-reperfusion-injury-in-an-ex-vivo-renal-porcine-model-of-the-donation-after-cardiac-death
#7
Rabindra N Bhattacharjee, Mahms Richard-Mohamed, Qizhi Sun, Aaron Haig, Ghaleb Aboalsamh, Peter Barrett, Richard Mayer, Ibrahim Alhasan, Karen Pineda-Solis, Larry Jiang, Hajed Alharbi, Manujendra Saha, Eric Patterson, Alp Sener, Gediminas Cepinskas, Anthony M Jevnikar, Patrick P W Luke
BACKGROUND: Carbon monoxide (CO) inhalation protects organ by reducing inflammation and cell death during transplantation processes in animal model. However, using CO in clinical transplantation is difficult due to its delivery in a controlled manner. A manganese-containing CORM-401 has recently been synthesized which can efficiently deliver 3 molar equivalents of CO. We report the ability of this anti-inflammatory CORM-401 to reduce ischemia reperfusion injury associated with prolonged cold storage of renal allografts obtained from donation after cardiac death in a porcine model of transplantation...
April 19, 2018: Transplantation
https://www.readbyqxmd.com/read/29677036/coupled-opg-fc-on-decellularized-aortic-valves-by-edc-nhs-attenuates-rat-mscs-calcification-in-vitro
#8
Qiao Zhang, Si Chen, Jiawei Shi, Fei Li, Xucong Shi, Xingjian Hu, Cheng Deng, Feng Shi, Guichun Han, Nianguo Dong
Valve calcification commonly damages natural human heart valves and tissue-engineered heart valves (TEHVs), and no ideal intervention is available in clinical practice. It is increasingly considered that osteoprotegerin (OPG) inhibits vascular calcification. We aimed to explore whether free OPG-Fc fusion protein or coupled OPG-Fc on decellularized aortic valves attenuates calcification. Calcification of rat bone marrow-derived mesenchymal stromal cells (MSCs) was induced by osteogenic differentiation media, and the effects of free OPG-Fc or OPG-Fc coupled on the decellularized porcine aortic heart valve leaflet scaffolds by coupling agents 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC)/N-hydroxysuccinimide (NHS) on calcification were observed...
April 18, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29676779/synergistic-effect-of-interleukin-17-and-tumor-necrosis-factor-%C3%AE-on-inflammatory-response-in-hepatocytes-through-interleukin-6-dependent-and-independent-pathways
#9
Audrey Beringer, Ndieme Thiam, Jennifer Molle, Birke Bartosch, Pierre Miossec
The pro-inflammatory cytokines IL-17 and TNFα are targets for treatment in many chronic inflammatory diseases. Here, we examined their role in liver inflammatory response compared to that of IL-6. Human hepatoma cells (HepaRG, Huh7.5 and HepG2 cells) and primary human hepatocytes (PHH) were cultured with IL-6, IL-17 and/or TNFα. To determine the contribution of the IL-6 pathway in the IL-17/TNFα-mediated effect, an anti-IL-6 receptor antibody was used. IL-17 and TNFα increased in synergy IL-6 secretion by HepaRG cells and PHH but not by Huh7...
April 20, 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29676656/the-effects-of-beta-hydroxy-beta-methylbutyrate-supplementation-on-recovery-following-exercise-induced-muscle-damage-a-systematic-review-and-meta-analysis
#10
Mohammad Hossein Rahimi, Hamed Mohammadi, Hesam Eshaghi, Gholamreza Askari, Maryam Miraghajani
BACKGROUND: Growing evidence suggests beta-hydroxy-beta-methylbutyrate's (HMB) positive effects on recovery following exercise-induced muscle damage (EIMD). However, findings vary substantially across studies. OBJECTIVE: A meta-analysis of randomized controlled trials was conducted to assess the effects of HMB supplementation on recovery following EIMD by assessing indirect markers of muscle damage, namely creatine kinase (CK) and lactate dehydrogenase (LDH) serum levels among healthy participants...
April 20, 2018: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/29676606/awareness-of-mutational-artefacts-in-suboptimal-dna-samples-possible-risk-for-therapeutic-choices
#11
Sara Mariani, Luca Bertero, Vittoria Coppola, Giorgio Saracco, Alberto Arezzo, Paola Francia di Celle, Jasna Metovic, Caterina Marchiò, Paola Cassoni
BACKGROUND: Technical biases due to PCR artefacts could represent an insidious obstacle for mutational analysis and precision medicine. METHODS: The authors report a retrospective analysis by fast COLD-PCR and sequencing of 31 suboptimal tumor DNA samples obtained from FFPE tissues and liquid biopsies. RESULTS: In FFPE tumor tissues and plasma liquid biopsies of patients with lung and colorectal adenocarcinoma, we observed a significant rate of artefactual KRAS mutations, unveiled by repeated analysis following UDG pretreatment as well as by simple repetition without UDG pretreatment step, thus suggesting a DNA damage different from cytosine deamination...
April 20, 2018: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/29676484/structural-and-metabolic-brain-correlates-of-apathy-in-huntington-s-disease
#12
Saul Martínez-Horta, Jesús Perez-Perez, Frederic Sampedro, Javier Pagonabarraga, Andrea Horta-Barba, Mar Carceller-Sindreu, Beatriz Gomez-Anson, Gloria Andrea Lozano-Martinez, Diego Alfonso Lopez-Mora, Valle Camacho, Alejandro Fernández-León, Ignasi Carrió, Jaime Kulisevsky
BACKGROUND: Apathy is the most prevalent and characteristic neuropsychiatric feature of Huntington's disease. Congruent with the main early pathological changes, apathy is primarily associated with subcortical damage in frontal-striatal circuits. However, little is known about its precise subserving mechanisms and the contribution of regions other than the basal ganglia. OBJECTIVES: We aimed to define the neural correlates of apathy in Huntington's disease based on gray matter volume and PET/CT of 18 F-fluorodeoxyglucose metabolism...
April 20, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29676295/effects-of-parenteral-papaverine-and-piracetam-administration-on-cochlea-following-acoustic-trauma
#13
Nurcan Yurtsever Kum, Yavuz F Yilmaz, Seren G Gurgen, Rauf O Kum, Muge Ozcan, Adnan Unal
Introduction: Noise exposure, the main cause of hearing loss in countries with lot of industries, may result both in temporary or permanent hearing loss. The goal of this study was to investigate the effects of parenteral papaverine and piracetam administration following an acoustic trauma on hearing function with histopathologic correlation. Materials and Methods: Eighteen Wistar albino rats exposed to noise for 8 h in a free environment were included. We divided the study population into three groups, and performed daily intraperitoneal injections of papaverine, piracetam, and saline, respectively, throughout the study...
March 2018: Noise & Health
https://www.readbyqxmd.com/read/29676135/-protective-effect-of-longxue-tongluo-capsule-on-oxidized-low-density-lipoprotein-damage-to-human-umbilical-vein-endothelial-cells
#14
Hong-Mei Wang, Jian-Ming Zhou, Yao-Zhong Lv, Jun Zhou, Zhen-Zhong Wang, Wen-Zhe Huang, Peng-Fei Tu, Wei Xiao
To observe the protective effect of Longxue Tongluo capsule (LTC) on human umbilical vein endothelial cells (EAhy.926 cells) injury induced by oxidized low-density lipoprotein (ox-LDL, 100 mg·L⁻¹). The effect of the cell viability of LTCin alleviating OX-LDL-induced endothelial cell injury was determined by MTT and LDH assay. The effect of LTC on lactic dehydrogenase (LDH), nitric oxide (NO), super oxide dlsmutase (SOD) and malondialdehyde (MDA) levels were detected by corresponding assay kits according to manufacturer's instruction...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29676105/-effects-of-tongbi-capsule-on-joint-lesions-in-rabbits-with-rheumatoid-arthritis
#15
Qing-Yong Cao, Pei-Yuan Wang, Qiao-Yun Wang, Feng Zhao, Ke-Zhan Wang, Jun-Qi Liu, Tong-Shen Liu, Yuan-Fang Wang, Yong-Jun Liu
The purpose of this experiment is to observe the effects of Tongbi capsule on joint lesions in rabbit with rheumatoid arthritis induced by ovalbumin and explore the mechanism in order to provide reference for clinical application of Tongbi capsule. Rheumatoid arthritis in rabbits was induced by subcutaneous injection of emulsions of ovalbumin and Freund's complete adjuvant and intra articular injection of ovalbumin. After successful modeling, 30 New Zealand rabbits with arthritis were randomly divided into model control group, the high, medium and low dose groups of Tongbi capsule (90, 45, 22...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29675920/long-term-feasibility-and-biocompatibility-of-directly-microsurgically-implanted-intrafascicular-electrodes-in-free-roaming-rabbits
#16
Gehua Zhen, Huanwen Chen, Shin-Yi Tsai, Jian Zhang, Tongyi Chen, Xiaofeng Jia
Novel neural interfaces capable of reliably capturing electrical signals are crucial for the development of prostheses. Longitudinal intrafascicular electrodes (LIFEs) have been proposed as a promising technology, and their feasibility and biocompatibility need to be investigated for long-term implantation. In this study, custom-designed 95%Pt-5%Ir intrafascicular electrodes were implanted into the sciatic nerves of 14 rabbits using our novel direct microsurgical technique. The biocompatibility and their ability to record electrophysiological signals were serially investigated up to 9 months after implantation...
April 19, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29675862/hemodialysis-a-model-for-extreme-physiology-in-a-vulnerable-patient-population
#17
REVIEW
Jeroen P Kooman, Krassimir Katzarski, Frank M van der Sande, Karel M Leunissen, Peter Kotanko
Hemodialysis (HD) is a lifesaving treatment for patients with end-stage renal disease, which is very efficient in the correction of abnormalities of the internal environment. However, this efficiency also induces significant hemodynamic, thermal, and respiratory stressors. These have parallels with the extreme physiologic demands which are normally mainly experienced by healthy subjects under adverse environmental conditions, with the difference that they must be endured by a vulnerable patient population. Hemodynamic stress induced by ultrafiltration leads to a decline in circulating blood volume, which may result in intradialytic hypotension (IDH) and changes in tissue perfusion, which may have long-term consequences for the function of vital organs such as the brain and the heart...
April 19, 2018: Seminars in Dialysis
https://www.readbyqxmd.com/read/29675804/lactobacillus-plantarum-displaying-conserved-m2e-and-ha2-fusion-antigens-induces-protection-against-influenza-virus-challenge
#18
Wen-Tao Yang, Gui-Lian Yang, Liang Zhao, Yu-Bei Jin, Yan-Long Jiang, Hai-Bin Huang, Chun-Wei Shi, Jian-Zhong Wang, Guan Wang, Yuan-Huan Kang, Chun-Feng Wang
Avian influenza virus (AIV) can infect poultry, mammals, and other hosts and causes enormous economic losses to the global poultry industry. In this study, to develop a novel and potent oral vaccine based on Lactobacillus plantarum (L. plantarum) for controlling the spread of AIV in the poultry industry, we constructed a recombinant L. plantarum strain displaying the 3M2e-HA2 protein of the influenza virus and determined the effect of N/pgsA'-3M2e-HA2 against AIV in chicks. We first confirmed that the 3M2e-HA2 fusion protein was expressed on the surface of L...
April 19, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29675624/tuberculosis-and-systemic-lupus-erythematosus-a-case-control-study-in-mexico-city
#19
Pedro Torres-González, Juanita Romero-Díaz, Miguel Enrique Cervera-Hernández, Mario Ocampo-Torres, Luis Gerardo Chaires-Garza, Ernesto Alejandro Lastiri-González, Yemil Atisha-Fregoso, Miriam Bobadilla-Del-Valle, Alfredo Ponce-de-León, José Sifuentes-Osornio
To determine, among systemic lupus erythematosus patients, factors associated with active tuberculosis. We performed a case-control study, in a tertiary-care center in Mexico City. We defined cases as systemic lupus erythematosus patients with active tuberculosis and matched them 1:1 with systemic lupus erythematosus patients without tuberculosis (controls) by age, date of systemic lupus erythematosus diagnosis, and disease duration. We analyzed clinical variables, lupus disease activity (SLEDAI-2K), and accumulated damage (SLICC/ARC-DI)...
April 20, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29675575/bezafibrate-prevents-glycine-induced-increase-of-antioxidant-enzyme-activities-in-rat-striatum
#20
Belisa Parmeggiani, Mateus Grings, Nevton Teixeira da Rosa-Junior, Renata Britto, Moacir Wajner, Guilhian Leipnitz
Non-ketotic hyperglycinemia (NKH) is a severe neurological disorder caused by defects in glycine (GLY) catabolism and characterized by a high cerebrospinal fluid/plasma GLY ratio. Treatment is often ineffective and limited to the control of symptoms and detoxification of GLY. In the present work, we investigated the in vivo effects of GLY intracerebroventricular administration on oxidative stress parameters in rat striatum, cerebral cortex, and hippocampus. In vitro effects of GLY were also evaluated in striatum...
April 19, 2018: Molecular Neurobiology
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