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https://www.readbyqxmd.com/read/28215050/racial-disparities-in-preventable-risk-factors-for-head-and-neck-cancer
#1
Sunshine Dwojak, Neil Bhattacharyya
OBJECTIVES/HYPOTHESIS: To demonstrate racial differences in preventable risk behaviors/practices that contribute to head and neck cancer (HNCA). STUDY DESIGN: Cross-sectional analysis of large national risk factor survey. METHODS: The Behavioral Risk Factor Surveillance System for 2013 was analyzed. Demographic data were extracted, including age, sex, and race. Social habits considered risk factors for HNCA were also extracted, including alcohol consumption, smoking, and human papillomavirus (HPV) vaccination status...
February 19, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28213874/disease-burden-of-human-papillomavirus-infection-in-the-netherlands-1989-2014-the-gap-between-females-and-males-is-diminishing
#2
Scott A McDonald, Venetia Qendri, Johannes Berkhof, Hester E de Melker, Johannes A Bogaards
PURPOSE: Besides cervical cancer, HPV infection is linked to a multitude of diseases in both males and females, suggesting that vaccination programmes should be re-evaluated, with a judicious assessment made of the disease burden stratified by sex, age, and genotype. Projections of burden into the near future are also needed to provide a benchmark for evaluating the impact of vaccination programmes, and to assess the need for scaling-up preventive measures. METHODS: Using the disability-adjusted life-years (DALY) measure, we estimated the total HPV-associated disease burden in the Netherlands...
February 17, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28192460/knowledge-attitudes-practices-and-willingness-to-vaccinate-in-preparation-for-the-introduction-of-hpv-vaccines-in-bamako-mali
#3
Anne S De Groot, Karamoko Tounkara, Mali Rochas, Sarah Beseme, Shahla Yekta, Fanta Siby Diallo, J Kathleen Tracy, Ibrahima Teguete, Ousmane A Koita
Although screening for pre-cancerous cervical lesions and human papilloma virus (HPV) vaccination are accepted and effective means to prevent cervical cancer, women in Mali have limited access to these interventions. In addition, cervical cancer prevention by HPV vaccination has been controversial in some settings. To reduce cervical cancer prevalence and increase HPV vaccine uptake, it is important to understand the level of knowledge about cervical cancer screening and practices related to vaccination in at-risk populations...
2017: PloS One
https://www.readbyqxmd.com/read/28178116/genital-human-papillomavirus-infection-in-indian-hiv-seropositive-men-who-have-sex-with-men
#4
Anantharam Raghavendran, Alexandra L Hernandez, Shelly Lensing, Manu Gnanamony, Rajiv Karthik, Murgesan Sivasubramanian, Rajesh Kannangai, Priya Abraham, Dilip Mathai, Joel M Palefsky
BACKGROUND: The incidence of penile cancer in Indian men is high. Little is known about genital human papillomavirus (HPV) infection in Indian HIV-seropositive men who have sex with men (MSM), a population that may be at particularly high risk for genital HPV infection and, potentially, penile cancer. In this study, we assessed the prevalence and risk factors for genital HPV infection in this population. DESIGN AND METHODS: Three hundred HIV-seropositive MSM were recruited from 2 clinical sites in India...
March 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28178115/prevalence-of-and-risk-factors-for-oral-human-papillomavirus-infection-with-multiple-genotypes-in-the-united-states
#5
Thanh Cong Bui, Ly Thi-Hai Tran, Thuy Nhu Thai, Sanjay S Shete, Damon J Vidrine, Erich M Sturgis
BACKGROUND: This study investigated the prevalence of and risk factors for oral human papillomavirus (HPV) infection with multiple genotypes in the United States. METHODS: Data were from the nationally representative 2009-2012 National Health and Nutrition Examination Survey. This analysis comprised 9257 participants for whom data on oral HPV (37 genotypes) and associated risk factors were available. RESULTS: The weighted prevalence of multitype (2-6 types) oral HPV infection was 1...
March 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28171876/clinical-value-of-the-epstein-barr-virus-and-p16-status-in-patients-with-nasopharyngeal-carcinoma-a-single-centre-study-in-japan
#6
Yuki Saito, Tetsuo Ushiku, Go Omura, Kazuo Yasuhara, Masafumi Yoshida, Wataru Takahashi, Mizuo Ando, Masashi Fukayama, Tatsuya Yamasoba
BACKGROUND: The clinical significance of the Epstein-Barr virus (EBV) status and p16 expression was unknown in nasopharyngeal carcinoma (NPC). METHODS: We retrospectively studied our pathology database for 13 years to determine the prevalence of EBV and p16 expression and their association with prognosis in cases of NPC. We performed immunohistochemistry for the p16 protein and in situ hybridization (ISH) for EBV-encoded small RNAs and human papillomavirus (HPV) DNA...
February 8, 2017: ORL; Journal for Oto-rhino-laryngology and its related Specialties
https://www.readbyqxmd.com/read/28171702/awareness-of-hpv-infection-and-attitudes-toward-hpv-vaccination-among-latvian-adolescents
#7
Hersha Patel, Kristine Pčolkina, Kristine Strazdina, Ilza Viberga, Susan M Sherman, Douglas G Tincello, Charles W Redman, Dace Rezeberga, Esther L Moss
OBJECTIVE: To evaluate awareness of HPV and its vaccine among Latvian adolescents. METHODS: A cross-sectional survey was conducted in a 2-week period in September 2015 among 270 adolescents attending a secondary school in Riga, Latvia. All students present during sexual-health classes (grades 10-12 [aged 16-21 years]) were included. A self-administered paper-based survey assessed sociodemographic factors, sexual behaviours, smear history and knowledge of sexually transmitted infections, HPV and HPV vaccine knowledge, and sources of information...
February 7, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28161418/us-medical-students-willingness-to-offer-the-hpv-vaccine-by-vaccination-status
#8
Abbey B Berenson, Jacqueline M Hirth, Erika L Fuchs
We surveyed third-year medical students to assess whether personal vaccination status was associated with willingness to recommend the human papillomavirus vaccine to patients. A total of 231 students completed an anonymous survey evaluating their knowledge, attitudes, and personal vaccine history. Of 122 female students, 81 (66.4%) reported initiating the vaccine, as did 16 of 109 males (14.7%). Females and students ⩽25years old were more likely to be vaccinated. Knowledge did not vary by vaccination status, but anticipated behaviors did...
February 1, 2017: Vaccine
https://www.readbyqxmd.com/read/28146168/colorectal-cancer-prevalence-linked-to-human-papillomavirus-a-systematic-review-with-meta-analysis
#9
Thaisa Pelizzer, Caroline Pieta Dias, Julia Poeta, Tânia Torriani, Cristian Roncada
Introduction: Colorectal cancer is one of the most prevalent types of tumors worldwide. Deaths caused by these malignant tumors remain high and have stayed practically at the same level for the last few decades. Among the established risk factors for the development of cancer are infections due to pathogens or viruses. Among the viruses, the human papillomavirus (HPV) is the most prevalent, with over 180 strains, 40 of which are directly related to anogenital infections. Objective: Systematically assess the main studies which link HPV to colorectal cancer with meta-analysis...
October 2016: Revista Brasileira de Epidemiologia, Brazilian Journal of Epidemiology
https://www.readbyqxmd.com/read/28125576/invasive-cancer-incidence-and-survival-united-states-2013
#10
S Jane Henley, Simple D Singh, Jessica King, Reda J Wilson, Mary Elizabeth O'Neil, A Blythe Ryerson
Although cancer represents many heterogeneous diseases, some cancer types share common risk factors. For example, conclusive evidence links cancer at multiple sites with tobacco use, alcohol use, human papillomavirus (HPV) infection, excess body weight, and physical inactivity (1,2). To monitor changes in cancer incidence and assess progress toward achieving Healthy People 2020 objectives,* CDC analyzed data from the U.S. Cancer Statistics (USCS) data set for 2013, the most recent year for which incidence and survival data are available...
January 27, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28121292/ranpirnase-eradicates-human-papillomavirus-in-cultured-cells-and-heals-anogenital-warts-in-a-phase-i-study
#11
Luis Squiquera, Debra J Taxman, Sarah A Brendle, Roberto Torres, Jamie Sulley, Thomas Hodge, Neil Christensen, David Sidransky
BACKGROUND: Human papillomaviruses (HPV), the causative agent of anogenital warts, are the most prevalent sexually transmitted infectious agents, and wart treatment poses a persistent challenge. We assessed the safety and efficacy of treating HPV with ranpirnase, an endoribonuclease from the Northern Leopard frog that has been used extensively in Phase III oncology trials. METHODS: As initial verification of ranpirnase antiviral activity, we assessed its ability to eliminate papillomaviruses in cultured cells...
January 25, 2017: Antiviral Therapy
https://www.readbyqxmd.com/read/28119475/%C3%AE-defensin-hd5-inhibits-human-papillomavirus-16-infection-via-capsid-stabilization-and-redirection-to-the-lysosome
#12
Mayim E Wiens, Jason G Smith
: α-Defensins are an important class of abundant innate immune effectors that are potently antiviral against a number of nonenveloped viral pathogens; however, a common mechanism to explain their ability to block infection by these unrelated viruses is lacking. We previously found that human defensin 5 (HD5) blocks a critical host-mediated proteolytic processing step required for human papillomavirus (HPV) infection. Here, we show that bypassing the requirement for this cleavage failed to abrogate HD5 inhibition...
January 24, 2017: MBio
https://www.readbyqxmd.com/read/28114440/prevalence-of-genital-human-papillomavirus-infection-and-human-papillomavirus-vaccination-rates-among-us-adult-men-national-health-and-nutrition-examination-survey-nhanes-2013-2014
#13
Jasmine J Han, Thomas H Beltran, John W Song, John Klaric, Y Sammy Choi
Importance: Human papillomavirus (HPV) is a common sexually transmitted infection that is a major cause of noncervical anogenital and oropharyngeal cancers. Prophylactic HPV vaccine is available for primary prevention. However, the population prevalence data for male genital HPV infection is not well known, while the HPV vaccination coverage is low in the United States. Objectives: To estimate the prevalence of genital HPV infection and the HPV vaccination rate in the United States among adult men and to examine potential risk factors for HPV infection...
January 19, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28109473/competing-causes-of-death-in-the-head-and-neck-cancer-population
#14
Sean T Massa, Nosayaba Osazuwa-Peters, Kara M Christopher, Lauren D Arnold, Mario Schootman, Ronald J Walker, Mark A Varvares
PURPOSE/OBJECTIVES: The increasing survivorship of head and neck squamous cell carcinoma (HNSCC) comes with a risk of death from other causes, known as competing causes. The demographics of HNSCC are also evolving with increasing incidence of Human Papillomavirus (HPV) associated tumors. This study describes competing causes of death for the HNSCC population compared to the general population and identifies associated risk factors. METHODS: Adult patients with first mucosal HNSCC (2004-2011) were identified from the Surveillance, Epidemiology and End Result database...
February 2017: Oral Oncology
https://www.readbyqxmd.com/read/28104720/when-dizziness-becomes-sinister-oropharyngeal-carcinoma-presenting-as-a-paraneoplastic-neurological-disorder
#15
Li Yong, Panagiotis Asimakopoulos, Colin Mumford, Ioanna Fragkandrea Nixon
Paraneoplastic neurological disorders are uncommon presentations of head and neck cancers. We present a case of a 68-year-old male patient who presented with dizziness, nausea and memory problems. MRI of his brain showed bilateral cerebellar leptomeningeal enhancing signal abnormality with cervical lymphadenopathy. CT imaging of his neck raised the suspicion of a tonsillar primary, which was later confirmed on biopsy. His poorly differentiated HPV positive squamous cell carcinoma was treated with chemoradiotherapy...
January 19, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28095289/prevalence-of-hpv-infection-in-croatian-men-during-a-12-year-period-a-comparative-study-of-external-genital-and-urethral-swabs
#16
Zora Profozić, Tomislav Meštrović, Ivan Savić, Velimir Profozić
AIM: The aim of the study was to compare the prevalence and distribution of both low-risk and high-risk HPV infection of the urethra and outer genital region in Croatian men. Thus far there is a consensus that sampling the coronal sulcus and glans of the penis is essential for adequately assessing HPV status in men but less agreement is noted for urethral sampling. METHODS: External genital brushing and urethral swabs were taken from 1,342 men during a 12-year period and tested with the hc2 HPV DNA Test using Hybrid Capture 2 technology...
December 2016: Central European Journal of Public Health
https://www.readbyqxmd.com/read/28094077/human-papillomavirus-vaccine-series-completion-in-boys-before-and-after-recommendation-for-routine-immunization
#17
Bradley Ackerson, Rulin Hechter, Margo Sidell, Lina S Sy, Jeffrey Slezak, Chun Chao, Nilesh Patel, Hung-Fu Tseng, Steven Jacobsen
BACKGROUND: Although the incidence of HPV-attributable cancers in males is rapidly increasing, HPV vaccine uptake in males remains poor. While quadrivalent human papillomavirus vaccine (4vHPV) series initiation in males increased following the Advisory Committee Immunization Practices (ACIP) male routine use recommendation, its impact on 4vHPV series completion in males at ACIP-recommended intervals has not been evaluated in large male cohorts. We examined trends and correlates of 4vHPV completion since licensure in males in a large cohort of insured boys before and after the ACIP routine use recommendation...
February 7, 2017: Vaccine
https://www.readbyqxmd.com/read/28087890/overview-of-the-benefits-and-potential-issues-of-the-nonavalent-hpv-vaccine
#18
REVIEW
Luciano Mariani, Mario Preti, Paolo Cristoforoni, Carlo M Stigliano, Antonio Perino
HPV-related diseases affect anogenital and oropharyngeal regions, heavily affecting the psychosexual dimension of both male and female individuals. HPV vaccination programs based on a bivalent or quadrivalent vaccine have opened broad perspectives for primary prevention. A nonavalent HPV vaccine (9vHPV), covering nine genotypes (HPV6, HPV11, HPV16, HPV18, HPV31, HPV33, HPV45, HPV52, and HPV58), might provide further improvement in terms of direct protection. In the present report, efficacy and safety data from 9vHPV vaccine development programs are examined...
December 7, 2016: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28073618/characteristics-of-adolescents-lacking-provider-recommended-human-papillomavirus-vaccination
#19
Melinda Krakow, Anna Beavis, Olivia Cosides, Anne F Rositch
PURPOSE: To characterize subgroups of teens in the United States for whom provider recommendation is less likely to impact human papillomavirus (HPV) vaccine initiation. METHODS: We analyzed provider-verified vaccination data from the Centers for Disease Control and Prevention's 2014 National Immunization Survey-Teen. Poisson regression models identified characteristics associated with the lack of HPV vaccine initiation among teens who received a provider recommendation (n = 12,742)...
January 7, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28056116/comparison-of-survival-outcomes-among-human-papillomavirus-negative-ct1-2-n1-2b-patients-with-oropharyngeal-squamous-cell-cancer-treated-with-upfront-surgery-vs-definitive-chemoradiation-therapy-an-observational-study
#20
Jacqueline R Kelly, Henry S Park, Yi An, Joseph N Contessa, Wendell G Yarbrough, Barbara A Burtness, Roy Decker, Zain Husain
Importance: Human papillomavirus (HPV)-negative oropharyngeal squamous cell carcinoma (OPSCC) has shown resistance to conventional concurrent chemoradiation (CRT) therapy and carries a relatively poor prognosis in comparison with HPV-positive disease, with decreased locoregional control and overall survival (OS). In the present analysis, we examine whether upfront surgical resection improves overall survival in a large national sample. Objective: To compare survival outcomes among patients with newly diagnosed cT1-2 N1-2b HPV-negative OPSCC when treated with primary surgical resection vs CRT...
January 5, 2017: JAMA Oncology
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