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Functional MR

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https://www.readbyqxmd.com/read/28237302/yiqifumai-powder-injection-attenuates-coronary-artery-ligation-induced-myocardial-remodeling-and-heart-failure-through-modulating-mapks-signaling-pathway
#1
Li-Zhi Pang, Ai-Chun Ju, Xian-Jie Zheng, Fang Li, Yun-Fei Song, Yan Zhao, Yuan-Feng Gu, Fei-Leng Chen, Chun-Hua Liu, Jin Qi, Zhen Gao, Jun-Ping Kou, Bo-Yang Yu
ETHNOPHARMACOLOGICAL RELEVANCE: YiQiFuMai Powder Injection (YQFM), a traditional Chinese medicine prescription re-developed based on Sheng-Mai-San, is a classical and traditional therapeutic for clinical heart failure (HF) and angina. However, its potential mechanism against HF remains unclear. AIM OF THE STUDY: The present study observes the therapeutic role of YQFM and mechanisms underlying its effects on coronary artery ligation (CAL)-induced myocardial remodeling (MR) and HF...
February 22, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28237285/long-term-outcomes-after-mitraclip-implantation-according-to-the-presence-or-absence-of-everest-inclusion-criteria
#2
Hasema Lesevic, Michael Karl, Daniel Braun, Petra Barthel, Martin Orban, Jürgen Pache, Martin Hadamitzky, Julinda Mehilli, Lynne Stecher, Steffen Massberg, Ilka Ott, Heribert Schunkert, Adnan Kastrati, Carolin Sonne, Jörg Hausleiter
Numerous patients are treated with the MitraClip, although they do not fulfill the stringent inclusion criteria of the Endovascular Valve Edge-to-Edge Repair Study (EVEREST) trials. The outcome of those patients is not well known. Therefore, we compared the long-term outcome after MitraClip treatment between patients who matched (group 1) and did not match (group 2) the EVEREST criteria. One hundred thirty-four consecutive patients were treated from September 2009 to July 2012: 59 patients (44%) in group 1 versus 75 patients (56%) in group 2...
January 25, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28237004/nuclear-medicine-in-pediatric-cardiology
#3
REVIEW
Ornella Milanesi, Giovanni Stellin, Pietro Zucchetta
Accurate cardiovascular imaging is essential for the successful management of patients with congenital heart disease (CHD). Echocardiography and angiography have been for long time the most important imaging modalities in pediatric cardiology, but nuclear medicine has contributed in many situations to the comprehension of physiological consequences of CHD, quantifying pulmonary blood flow symmetry or right-to-left shunting. In recent times, remarkable improvements in imaging equipments, particularly in multidetector computed tomography and magnetic resonance imaging, have led to the progressive integration of high resolution modalities in the clinical workup of children affected by CHD, reducing the role of diagnostic angiography...
March 2017: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/28236649/spectral-characterization-of-tissues-in-high-spectral-and-spatial-resolution-mr-images-implications-for-a-classification-based-synthetic-ct-algorithm
#4
Abbie M Wood, Steven M Shea, Milica Medved, Gregory S Karczmar, Murat Surucu, Sebastien Gros, William Small, John Roeske
PURPOSE: To characterize spectral parameters of tissues with high spectral and spatial resolution magnetic resonance images to be used as a foundation for a classification-based synthetic CT algorithm. METHODS: A phantom was constructed consisting of a section of fresh beef leg with bone embedded in a 1% agarose gel. The high spectral and spatial (HiSS) resolution MR imaging sequence used had 1.0mm in-plane resolution and 11.1Hz spectral resolution. This sequence was used to image the phantom and one patient...
February 25, 2017: Medical Physics
https://www.readbyqxmd.com/read/28236574/novel-biomarkers-of-human-gm1-gangliosidosis-reflect-the-clinical-efficacy-of-gene-therapy-in-a-feline-model
#5
Heather L Gray-Edwards, Debra S Regier, Jamie L Shirley, Ashley N Randle, Nouha Salibi, Sarah E Thomas, Yvonne L Latour, Jean Johnston, Gretchen Golas, Annie S Maguire, Amanda R Taylor, Donald C Sorjonen, Victoria J McCurdy, Peter W Christopherson, Allison M Bradbury, Ronald J Beyers, Aime K Johnson, Brandon L Brunson, Nancy R Cox, Henry J Baker, Thomas S Denney, Miguel Sena-Esteves, Cynthia J Tifft, Douglas R Martin
GM1 gangliosidosis is a fatal neurodegenerative disease that affects individuals of all ages. Favorable outcomes using adeno-associated viral (AAV) gene therapy in GM1 mice and cats have prompted consideration of human clinical trials, yet there remains a paucity of objective biomarkers to track disease status. We developed a panel of biomarkers using blood, urine, cerebrospinal fluid (CSF), electrodiagnostics, 7 T MRI, and magnetic resonance spectroscopy in GM1 cats-either untreated or AAV treated for more than 5 years-and compared them to markers in human GM1 patients where possible...
February 21, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28236336/cardiac-mr-elastography-for-quantitative-assessment-of-elevated-myocardial-stiffness-in-cardiac-amyloidosis
#6
Arvin Arani, Shivaram P Arunachalam, Ian C Y Chang, Francis Baffour, Phillip J Rossman, Kevin J Glaser, Joshua D Trzasko, Kiaran P McGee, Armando Manduca, Martha Grogan, Angela Dispenzieri, Richard L Ehman, Philip A Araoz
PURPOSE: To evaluate if cardiac magnetic resonance elastography (MRE) can measure increased stiffness in patients with cardiac amyloidosis. Myocardial tissue stiffness plays an important role in cardiac function. A noninvasive quantitative imaging technique capable of measuring myocardial stiffness could aid in disease diagnosis, therapy monitoring, and disease prognostic strategies. We recently developed a high-frequency cardiac MRE technique capable of making noninvasive stiffness measurements...
February 25, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28235371/enhanced-photovoltage-response-of-hematite-x-ferrite-interfaces-x-cr-mn-co-or-ni
#7
Liang Bian, Hai-Long Li, Yu-Jin Li, Jia-Nan Nie, Fa-Qin Dong, Hai-Liang Dong, Mian-Xin Song, Li-Sheng Wang, Tian-Liang Zhou, Xiao-Yan Zhang, Xin-Xi Li, Lei Xie
High-fluorescent p-X-ferrites (XFe2O4; XFO; X = Fe, Cr, Mn, Co, or Ni) embedded in n-hematite (Fe2O3) surfaces were successfully fabricated via a facile bio-approach using Shewanella oneidensis MR-1. The results revealed that the X ions with high/low work functions modify the unpaired spin Fe(2+)-O(2-) orbitals in the XFe2O4 lattices to become localized paired spin orbitals at the bottom of conduction band, separating the photovoltage response signals (73.36~455.16/-72.63~-32.43 meV). These (Fe2O3)-O-O-(XFe2O4) interfacial coupling behaviors at two fluorescence emission peaks (785/795 nm) are explained via calculating electron-hole effective masses (Fe2O3-FeFe2O4 17...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28231342/nonlinear-image-registration-with-bidirectional-metric-and-reciprocal-regularization
#8
Shihui Ying, Dan Li, Bin Xiao, Yaxin Peng, Shaoyi Du, Meifeng Xu
Nonlinear registration is an important technique to align two different images and widely applied in medical image analysis. In this paper, we develop a novel nonlinear registration framework based on the diffeomorphic demons, where a reciprocal regularizer is introduced to assume that the deformation between two images is an exact diffeomorphism. In detail, first, we adopt a bidirectional metric to improve the symmetry of the energy functional, whose variables are two reciprocal deformations. Secondly, we slack these two deformations into two independent variables and introduce a reciprocal regularizer to assure the deformations being the exact diffeomorphism...
2017: PloS One
https://www.readbyqxmd.com/read/28229131/discovering-cortical-folding-patterns-in-neonatal-cortical-surfaces-using-large-scale-dataset
#9
Yu Meng, Gang Li, Li Wang, Weili Lin, John H Gilmore, Dinggang Shen
The cortical folding of the human brain is highly complex and variable across individuals. Mining the major patterns of cortical folding from modern large-scale neuroimaging datasets is of great importance in advancing techniques for neuroimaging analysis and understanding the inter-individual variations of cortical folding and its relationship with cognitive function and disorders. As the primary cortical folding is genetically influenced and has been established at term birth, neonates with the minimal exposure to the complicated postnatal environmental influence are the ideal candidates for understanding the major patterns of cortical folding...
October 2016: Medical Image Computing and Computer-assisted Intervention: MICCAI ..
https://www.readbyqxmd.com/read/28228942/effects-of-renal-denervation-on-vascular-remodelling-in-patients-with-heart-failure-and-preserved-ejection-fraction-a-randomised-control-trial
#10
Hitesh C Patel, Carl Hayward, Jennifer Keegan, Peter D Gatehouse, Ronak Rajani, Rajdeep S Khattar, Raad H Mohiaddin, Stuart D Rosen, Alexander R Lyon, Carlo di Mario
OBJECTIVE: To assess the effect of renal denervation (RDT) on micro- and macro-vascular function in patients with heart failure with preserved ejection fraction (HFpEF). DESIGN: A prospective, randomised, open-controlled trial with blinded end-point analysis. SETTING: A single-centre London teaching hospital. PARTICIPANTS: Twenty-five patients with HFpEF who were recruited into the RDT-PEF trial. MAIN OUTCOME MEASURES: Macro-vascular: 24-h ambulatory pulse pressure, aorta distensibilty (from cardiac magnetic resonance imaging (CMR), aorta pulse wave velocity (CMR), augmentation index (peripheral tonometry) and renal artery blood flow indices (renal MR)...
January 2017: JRSM Cardiovascular Disease
https://www.readbyqxmd.com/read/28228788/safety-and-efficacy-of-vertebroplasty-in-the-treatment-of-osteoporotic-vertebral-compression-fractures-a-prospective-multicenter-international-randomized-controlled-study
#11
Paolo Tranquilli Leali, Federico Solla, Gianluca Maestretti, Massimo Balsano, Carlo Doria
BACKGROUND: Vertebral compression fractures (VCFs) treated non-operatively can diminish function and quality of life, and lead to chronic health effects. The short-term safety and effectiveness of vertebroplasty for symptomatic VCFs are well-documented, but long-term follow-up is needed. PURPOSE: The aim of this paper was to analyse a multicenter international experience of 200 compression fractures treated with percutaneous vertebroplasty (VP) and compare the results of this procedure with the result of 200 patients treated conservatively...
September 2016: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/28228636/progressive-ischemic-stroke-due-to-thyroid-storm-associated-cerebral-venous-thrombosis
#12
Natsumi Tanabe, Eiji Hiraoka, Masataka Hoshino, Gautam A Deshpande, Kana Sawada, Yasuhiro Norisue, Jumpei Tsukuda, Toshihiko Suzuki
BACKGROUND Cerebral venous thrombosis (CVT) is a rare but fatal complication of hyperthyroidism that is induced by the hypercoagulable state of thyrotoxicosis. Although it is frequently difficult to diagnose CVT promptly, it is important to consider it in the differential diagnosis when a hyperthyroid patient presents with atypical neurologic symptoms. CASE REPORT A 49-year-old Japanese female with unremarkable medical history came in with thyroid storm and multiple progressive ischemic stroke identified at another hospital...
February 23, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28227987/incorporating-shape-prior-into-active-contours-with-a-sparse-linear-combination-of-training-shapes-application-to-corpus-callosum-segmentation
#13
Mohammad M Farhangi, Hichem Frigui, Robert Bert, Amir A Amini, Mohammad M Farhangi, Hichem Frigui, Robert Bert, Amir A Amini, Robert Bert, Mohammad M Farhangi, Amir A Amini, Hichem Frigui
In this paper, a novel method of embedding shape information into level set image segmentation is proposed. Our method is based on inferring shape variations by a sparse linear combination of instances in the shape repository. Given a sufficient number of training shapes with variations, a new shape can be approximated by a linear span of training shapes associated with those variations. At each step of curve evolution the curve is moved to minimize Chan-Vese energy functional as well as toward the best approximation based on a linear combination of training samples...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227423/dynamic-mapping-of-ventricular-function-from-cardiovascular-magnetic-resonance-imaging
#14
Maria Panayiotou, Peter Mountney, Alexander Brost, Daniel Toth, Tom Jackson, Jonathan M Behar, Christopher A Rinaldi, R James Housden, Kawal S Rhode, Maria Panayiotou, Peter Mountney, Alexander Brost, Daniel Toth, Tom Jackson, Jonathan M Behar, Christopher A Rinaldi, R James Housden, Kawal S Rhode, Alexander Brost, Tom Jackson, Maria Panayiotou, Christopher A Rinaldi, Jonathan M Behar, R James Housden, Kawal S Rhode, Daniel Toth, Peter Mountney
Heart failure is associated with substantial mortality and morbidity and remains the most common diagnosis in older patients. Based on experimental electrophysiologic studies, cardiac resynchronization therapy (CRT) for heart failure results in a maximum resynchronization effect when applied to the most delayed left ventricular (LV) site. Current clinical practice is to identify the optimal site using separate visualisation of scar and activation information. These must be mentally mapped into 3D, which is challenging and time-consuming for the electrophysiologist...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227389/a-method-to-project-clinical-outcome-topographies-onto-preoperative-mri-to-guide-direct-dbs-targeting
#15
Mahesh B Shenai, Barton L Guthrie, Mahesh B Shenai, Barton L Guthrie, Barton L Guthrie, Mahesh B Shenai
The use of intraoperative MR and direct DBS targeting, relies on anatomical rather than functional data. Historical clinical outcome databases that have recorded stimulation location and magnitude of effect, can provide a useful adjunct in DBS targeting strategies. We present a method for generating clinical outcome topographies, and merging regions of effect onto a pre-operative MR, for surgical planning. The clinical outcome topographies are consistent with more intuitive strategies used by neurosurgeons...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226723/improving-assessment-of-congenital-heart-disease-through-rapid-patient-specific-modeling
#16
Kathleen Gilbert, Genevieve Farrar, Brett Cowan, Avan Suinesiaputra, Christopher Occleshaw, Beau Pontre, James Perry, Sanjeet Hegde, Jeffrey Omens, Andrew McCulloch, Alistair Young, Kathleen Gilbert, Genevieve Farrar, Brett Cowan, Avan Suinesiaputra, Christopher Occleshaw, Beau Pontre, James Perry, Sanjeet Hegde, Jeffrey Omens, Andrew McCulloch, Alistair Young, James Perry, Genevieve Farrar, Avan Suinesiaputra, Brett Cowan, Kathleen Gilbert, Jeffrey Omens, Christopher Occleshaw, Sanjeet Hegde, Beau Pontre, Andrew McCulloch, Alistair Young
Congenital heart disease is the most common birth defect, with an incidence of 75 in every 1000 births. As a result of improved interventions, 90% of people with congenital heart disease now survive to adulthood. They must undergo regular imaging to assess their biventricular (left and right ventricular) function. Analysis of the images is problematic due to the large variety of shapes and complex geometry. In this paper we extend a biventricular modeling method to improve the analysis of MR images from congenital heart disease patients...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226708/curvelet-based-residual-complexity-objective-function-for-non-rigid-registration-of-pre-operative-mri-with-intra-operative-ultrasound-images
#17
P Farnia, B Makkiabadi, A Ahmadian, J Alirezaie, P Farnia, B Makkiabadi, A Ahmadian, J Alirezaie, B Makkiabadi, A Ahmadian, P Farnia, J Alirezaie
Intra-operative ultrasound as an imaging based method has been recognized as an effective solution to compensate non rigid brain shift problem in recent years. Measuring brain shift requires registration of the pre-operative MRI images with the intra-operative ultrasound images which is a challenging task. In this study a novel hybrid method based on the matching echogenic structures such as sulci and tumor boundary in MRI with ultrasound images is proposed. The matching echogenic structures are achieved by optimizing the Residual Complexity (RC) in the curvelet domain...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225064/intravoxel-incoherent-motion-diffusion-weighted-mr-imaging-in-assessing-and-characterizing-solitary-pulmonary-lesions
#18
Qi Wan, Ying-Shi Deng, Jia-Xuan Zhou, Yu-Dong Yu, Ying-Ying Bao, Qiang Lei, Hou-Jin Chen, Ya-Hui Peng, Ying-Jie Mei, Qing-Si Zeng, Xin-Chun Li
This study aimed to investigate the potential of intravoxel incoherent motion (IVIM) diffusion-weighted MR imaging in assessing solitary pulmonary lesions (SPLs). Sixty-two patients with pathologically confirmed SPLs, including 51 and 11 cases of malignant and benign lesions, respectively, were assessed. Diffusion weighted imaging (DWI) with 13 b values was used to derive apparent diffusion coefficient (ADC) and IVIM parameters, including true diffusion coefficient (D), pseudo-diffusion coefficient (D*), and perfusion fraction (f)...
February 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28220266/interpretation-of-cardiac-wall-motion-from-cine-mri-combined-with-parametric-imaging-based-on-the-hilbert-transform
#19
Narjes Benameur, Enrico Gianluca Caiani, Younes Arous, Nejmeddine Ben Abdallah, Tarek Kraiem
OBJECT: The aim of this study was to test and validate the clinical impact of parametric amplitude images obtained using the Hilbert transform on the regional interpretation of cardiac wall motion abnormalities from cine-MR images by non-expert radiologists compared with expert consensus. MATERIALS AND METHODS: Cine-MRI short-axis images obtained in 20 patients (10 with myocardial infarction, 5 with myocarditis and 5 with normal function) were processed to compute a parametric amplitude image for each using the Hilbert transform...
February 20, 2017: Magma
https://www.readbyqxmd.com/read/28219811/stress-echocardiography-in-patients-who-experienced-mechanical-ventilation-weaning-failure
#20
Manuel Ruiz-Bailén, Jesús Cobo-Molinos, Ana Castillo-Rivera, María Dolores Pola-Gallego-de-Guzmán, Antonio Cárdenas-Cruz, Antonio Martínez-Amat, María Sevilla-Martínez, Clara Hernández-Caballero
INTRODUCTION: Critically ill patients may suffer varying degrees of temporary myocardial dysfunction during respiratory weaning that could play an important role in weaning failure. OBJECTIVES: In this study, we tried to assess the existence of temporary diastolic dysfunction during respiratory weaning. METHODS: Inclusion period is from 2006 to 2015. In this study, we included 181 ventilated patients with cardiogenic shock that were being weaned from mechanical ventilation...
January 18, 2017: Journal of Critical Care
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