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Soy, post menopausal, breast cancer, risk

Shurong Lu, Xingyu Huang, Hao Yu, Jie Yang, Renqiang Han, Jian Su, Wencong Du, Jinyi Zhou, Xiaojin Yu, Ming Wu
BACKGROUND: The incidence rate of breast cancer has markedly increased in recent years in China, yet the association of breast cancer with dietary patterns such as a Chinese traditional diet has not been studied. We aimed to examine this association among women from the Jiangsu Province of China. METHODS: In this case-control study, we used the data from local population-based cancer registry agency to recruit newly diagnosed patients with primary breast cancer as cases...
October 2016: Lancet
Meinan Chen, Yanhua Rao, Yi Zheng, Shiqing Wei, Ye Li, Tong Guo, Ping Yin
BACKGROUND: Conclusions drawn from meta-analyses on the association between soy isoflavone intake and breast cancer risk for pre- and post-menopausal women are not fully consistent. These meta-analyses did not explore the influence of different study designs on the pooled results on the basis of distinguishing between pre- and post-menopausal women. METHODOLOGY AND PRINCIPAL FINDINGS: We performed a meta-analysis of 35 studies which reported results of association between soy isoflavone intake and breast cancer risk for pre- and/or post-menopausal women, calculated pooled odds ratios and their 95% confidence intervals of pre- and post-menopausal women respectively, and further explored soy isoflavone-breast cancer association on the basis of considering different study regions and designs...
2014: PloS One
Luis Valladares, Argelia Garrido, Walter Sierralta
Accumulated exposure to high levels of estrogen is associated with an increased incidence of breast cancer. Thus, factors such as early puberty, late menopause and hormone replacement therapy are considered to be risk factors, whereas early childbirth, breastfeeding and puberty at a later age are known to consistently decrease the lifetime breast cancer risk. Epidemiological studies suggest that consumption of isoflavones correlates with a lower incidence of breast cancer. Data from human intervention studies show that the effects of isoflavones on early breast cancer markers differ between pre- and post-menopausal women...
April 2012: Revista Médica de Chile
Seema A Khan, Robert T Chatterton, Nancy Michel, Michelle Bryk, Oukseub Lee, David Ivancic, Richard Heinz, Carola M Zalles, Irene B Helenowski, Borko D Jovanovic, Adrian A Franke, Maarten C Bosland, Jun Wang, Nora M Hansen, Kevin P Bethke, Alexander Dew, Margerie Coomes, Raymond C Bergan
Soy isoflavone consumption may protect against breast cancer development. We conducted a phase IIB trial of soy isoflavone supplementation to examine its effect on breast epithelial proliferation and other biomarkers in the healthy high-risk breast. One hundred and twenty-six consented women underwent a random fine-needle aspiration (rFNA); those with 4,000 or more epithelial cells were randomized to a double-blind 6-month intervention of mixed soy isoflavones (PTIG-2535) or placebo, followed by repeat rFNA...
February 2012: Cancer Prevention Research
Xinmei Kang, Qingyuan Zhang, Shuhuai Wang, Xu Huang, Shi Jin
BACKGROUND: The intake of soy isoflavones among women with breast cancer has become a public health concern, because these compounds have weak estrogenic effects. There is little clinical evidence about their safety for patients with breast cancer who are receiving adjuvant endocrine therapy. METHODS: For patients who underwent surgery for breast cancer between August 2002 and July 2003 and who were receiving adjuvant endocrine therapy, we examined associations between dietary intake of soy isoflavones and recurrence of breast cancer and death...
November 23, 2010: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
Lee Hooper, Giri Madhavan, Jeffrey A Tice, Sam J Leinster, Aedín Cassidy
BACKGROUND: Isoflavones from soy and red clover exert modest hormonal effects in women, but the relevance to risk of breast cancer is unclear. The aim of this meta-analysis was to assess the effects of isoflavone-rich foods or supplements on a biomarker of breast cancer risk, women's mammographic density. METHODS: Electronic searches were performed on The Cochrane Library, Medline and EMBASE (to June 2009), and reference lists and trial investigators were consulted to identify further studies...
November 2010: Human Reproduction Update
S Basaria, A Wisniewski, K Dupree, T Bruno, M-Y Song, F Yao, A Ojumu, M John, A S Dobs
CONTEXT: Recent interventional studies indicate that post-menopausal hormone replacement therapy is associated with an increased risk of cardiovascular mortality and breast cancer. Isoflavones, a class of plant estrogens, have structural similarities to estradiol. Hence, isoflavones may exert beneficial estrogenic health effects in postmenopausal women with fewer adverse effects. OBJECTIVE: To evaluate the effect of high-dose isoflavones on self-reported quality of life (QOL), cognition, lipoproteins and androgen status in post-menopausal women...
February 2009: Journal of Endocrinological Investigation
Neela Guha, Marilyn L Kwan, Charles P Quesenberry, Erin K Weltzien, Adrienne L Castillo, Bette J Caan
Soy isoflavones, structurally similar to endogenous estrogens, may affect breast cancer through both hormonally mediated and non-hormonally related mechanisms. Although the effects of soy are not well understood, some breast cancer survivors increase their soy intake post-diagnosis in attempt to improve their prognosis. Therefore, we examined the role of soy isoflavone intake and the risk of breast cancer recurrence by hormone receptor status, menopausal status, and tamoxifen therapy. A cohort of 1,954 female breast cancer survivors, diagnosed during 1997-2000, was prospectively followed for 6...
November 2009: Breast Cancer Research and Treatment
Anna H Wu, Mimi C Yu, Chiu-Chen Tseng, Frank Z Stanczyk, Malcolm C Pike
The role of diabetes in the etiology of breast cancer in Asian-Americans is not known. We investigated the relation between diabetes and breast cancer risk in a population-based case-control study in Los Angeles County that included 1248 Asian-American women with incident, histologically confirmed breast cancer and 1148 control women, who were frequency matched to cases on age, Asian ethnicity and neighborhood of residence. The relation between history of diabetes and serum concentrations of estrogens, androgens and sex hormone-binding globulin (SHBG) was investigated in 212 post-menopausal control women...
July 2007: Carcinogenesis
Robert A DiSilvestro, Jaime Goodman, Emily Dy, Gregory Lavalle
Soy isoflavone antioxidant effects may help prevent breast cancer re-occurrence, but isoflavone estrogen-like actions may increase breast cancer risk. These isoflavone actions can be reflected by effects on two copper enzymes activities, superoxide dismutase 1 (SOD 1), which has antioxidant function relevant to breast cancer prevention, and ceruloplasmin, which has its synthesis up-regulated by estrogen, and for which high values are associated with high breast cancer risk. A soy isoflavone-rich concentrate supplement was examined for effects on these two copper enzyme activities in post-menopausal breast cancer survivors (n = 7) in a crossover design with a placebo (24 days on supplement or placebo; 14 day wash out)...
February 2005: Breast Cancer Research and Treatment
Jay H Fowke, Fung-Lung Chung, Fan Jin, Dai Qi, Qiuyin Cai, Cliff Conaway, Jia-Rong Cheng, Xiao-Ou Shu, Yu-Tang Gao, Wei Zheng
Brassica vegetable consumption (e.g., Chinese cabbage) provides isothiocyanates (ITC) and other glucosinolate derivatives capable of inducing Phase II enzymes [e.g., glutathione S-transferases (GSTM1, GSTT1, and GSTP1) and NADPH quinine oxidoreductase] and apoptosis, altering steroid hormone metabolism, regulating estrogen receptor response, and stabilizing cellular proliferation. Asian populations consuming large amounts of Brassica have a lower breast cancer incidence compared with Western populations; however, the association between Brassica consumption and breast cancer risk is uncertain...
July 15, 2003: Cancer Research
L Strauss, R Santti, N Saarinen, T Streng, S Joshi, S Mäkelä
Epidemiological studies suggest that diets rich in phytoestrogens (plant estrogens), particularly soy and unrefined grain products, may be associated with low risk of breast and prostate cancer. It has also been proposed that dietary phytoestrogens could play a role in the prevention of other estrogen-related conditions, namely cardiovascular disease, menopausal symptoms and post-menopausal osteoporosis. However, there is no direct evidence for the beneficial effects of phytoestrogens in humans. All information is based on consumption of phytoestrogen-rich diets, and the causal relationship and the mechanisms of phytoestrogen action in humans still remain to be demonstrated...
December 28, 1998: Toxicology Letters
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