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Sex differences chronic kidney disease

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https://www.readbyqxmd.com/read/28716010/risk-scores-to-predict-decreased-glomerular-filtration-rate-at-10%C3%A2-years-in-an-asian-general-population
#1
Krittika Saranburut, Prin Vathesatogkit, Nisakron Thongmung, Anchalee Chittamma, Somlak Vanavanan, Tuangrat Tangstheanphan, Piyamitr Sritara, Chagriya Kitiyakara
BACKGROUND: Asians have among the highest prevalence of chronic kidney disease (CKD) or end-stage renal disease in the world. A risk score capable of identifying high risk individuals at the primary care level could allow targeted therapy to prevent future development of CKD. Risk scores for new CKD have been developed in US general populations, but the impact of various risks factors for development of CKD may differ in Asian subjects. In this study, we aimed to develop risk models and simplified risk scores to predict the development of decreased glomerular filtration rate (GFR) at 10 years in an Asian general population using readily obtainable clinical and laboratory parameters...
July 17, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28711080/menopause-and-chronic-kidney-disease
#2
Sofia B Ahmed
Premature menopause defined as secondary amenorrhea is common in women with kidney disease. Moreover, the aging population has resulted in increasing numbers of postmenopausal women with kidney disease. Though the pathophysiology is poorly understood, kidney transplantation and more frequent hemodialysis can restore menses and fertility, highlighting the challenges of diagnosing and managing the menopausal transition in the female population with kidney disease. Postmenopausal sex hormone levels affect renovascular physiology, but the clinical impact of menopause on kidney function is unclear...
July 2017: Seminars in Nephrology
https://www.readbyqxmd.com/read/28695556/changing-trends-in-end-stage-renal-disease-patients-with-diabetes
#3
Yimin Lu, Christina Stamm, Dina Nobre, Menno Pruijm, Daniel Teta, Anne Cherpillod, Georges Halabi, Olivier Phan, Zina Fumeaux, Roberto Bullani, Thierry Gauthier, Claudine Mathieu, Michel Burnier, Anne Zanchi
BACKGROUND: Worldwide, diabetes has become the most common cause of end-stage renal disease (ESRD), yet Swiss data are largely lacking. METHODS: This observational study examined ESRD patients with diabetes mellitus (ESRD-DM) at end of 2009 and 2014. The prevalence and characteristics of ESRD-DM patients were collected in all dialysis facilities in the Canton of Vaud of Switzerland in 2009 and in 2014, and the 5-year mortality rate was assessed. RESULTS: A total of 107 and 140 ESRD-DM patients underwent dialysis at end of 2009 and 2014, respectively...
July 11, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28692645/benzodiazepine-and-z-drug-use-and-risk-of-pneumonia-in-patients-with-chronic-kidney-disease-a-population-based-nested-case-control-study
#4
Meng-Ting Wang, Yun-Han Wang, Hsin-An Chang, Chen-Liang Tsai, Ya-Sung Yang, Chen Wei Lin, Cheng-Chin Kuo, Yu-Juei Hsu
BACKGROUND: Concerns were raised about pneumonia development from benzodiazepines (BZDs) and Z-drugs, but direct evidence is limited, conflicting and without examining the highly susceptible patients with chronic kidney disease (CKD) nor specifying the risk for different drug utilizations. This study aimed to investigate whether use of BZDs and Z-drugs was each associated with an increased risk of pneumonia in a CKD population. METHODS: We performed a nested case-control study of 36,880 CKD patients analyzing the Taiwan National Health Insurance Database between 01/1/2000 and 12/31/2011...
2017: PloS One
https://www.readbyqxmd.com/read/28685173/health-related-quality-of-life-of-children-with-pre-dialysis-chronic-kidney-disease
#5
Hee Sun Baek, Hee Gyung Kang, Hyun Jin Choi, Hae Il Cheong, Il Soo Ha, Kyung Hee Han, Seong Heon Kim, Hee Yeon Cho, Jae Il Shin, Young Seo Park, Joo Hoon Lee, Joongyub Lee, Curie Ahn, Min Hyun Cho
BACKGROUND: The goal of this study was to evaluate the quality of life (QOL) of Asian children with pre-dialysis chronic kidney disease (CKD) and to reveal the factors influencing the QOL of children with CKD. METHODS: We performed a cross-sectional study of the PedsQL 4.0 Generic Core Scale Module in the KNOW-PedCKD (KoreaN cohort study for Outcome in patients with Pediatric Chronic Kidney Disease) cohort, and compared the child self-reported and parent proxy-reported QOL of the pediatric cohort...
July 6, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28633195/survival-of-patients-with-cancer-starting-chronic-dialysis-data-from-kidney-and-cancer-registries-in-lower-normandy
#6
Clémence Béchade, Olivier Dejardin, Simona Bara, Véronique Bouvier, Anne-Valérie Guizard, Rémy De Mil, Xavier Troussard, Guy Launoy, Thierry Lobbedez
AIM: Cancer and chronic kidney disease are known to be associated. The way in which a history of cancer can influence outcome in dialysis is not well described. This work aimed to evaluate survival of cancer patients starting chronic dialysis after their diagnosis of cancer. METHODS: We merged data from cancer registries and a dialysis registry, and explored patients' charts. RESULTS: Between January 2001 and December 2008, 74 patients with incident cancer in the two-counties-study-area (Calvados and Manche) started chronic dialysis after their diagnosis of cancer...
June 20, 2017: Nephrology
https://www.readbyqxmd.com/read/28621634/the-utility-of-screening-colonoscopy-during-kidney-transplant-evaluation
#7
Yu Zheng, Kevin V Chaung, Paul J Park, Joshua J Augustine, Nagaraju Sarabu, James A Schulak, Edmund Q Sanchez, Vanessa R Humphreville, John B Ammori, Kenneth J Woodside
OBJECTIVES: Transplant centers often recommend, but not necessarily require, screening colonoscopies for people over 50 years of age in accordance with the US Preventative Services Task Force guidelines for the general population. We sought to identify risk factors affecting colonoscopy results in renal failure patients undergoing kidney transplant evaluation. MATERIALS AND METHODS: We retrospectively examined patients undergoing kidney transplant evaluation from 2009 to 2012 (n = 469 patients)...
June 16, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28608311/potential-role-of-allopurinol-in-preventing-contrast-induced-nephropathy-in-patients-undergoing-percutaneous-coronary-intervention-a-randomized-placebo-controlled-trial
#8
Zahra Ghelich Khan, Azita Hajhossein Talasaz, Hamidreza Pourhosseini, Kianoush Hosseini, Mohammad Javad Alemzadeh Ansari, Arash Jalali
BACKGROUND: Contrast-induced nephropathy (CIN) is a major drawback in percutaneous coronary intervention (PCI). Significant uricosuria has been reported following contrast exposure. Allopurinol-a xanthine oxidase inhibitor-has been suggested to prevent the formation of oxygen-free radicals, which may contribute to CIN. The aim of the present study was to evaluate the possible efficacy of allopurinol in preventing CIN. METHODS: In this double-blind placebo-controlled trial, patients with an estimated glomerular filtration rate ≥60 mL/min who were admitted for elective PCI, were randomized to receive either allopurinol 600 mg or a placebo administered 24 h before the procedure, and again immediately before the procedure...
June 12, 2017: Clinical Drug Investigation
https://www.readbyqxmd.com/read/28579260/serum-cystatin-c-levels-are-associated-with-coronary-artery-calcification-in-women-without-chronic-kidney-disease
#9
Hiroyasu Sugiyama, Toru Miyoshi, Kazuhiro Osawa, Takashi Miki, Yuji Koide, Kazufumi Nakamura, Hiroshi Morita, Hiroshi Ito
BACKGROUND: Chronic renal disease (CKD) is a determinant of coronary artery calcification (CAC), which is a predictor of cardiovascular events. However, in a population without CKD, the association between CAC and renal function is unclear. CAC is affected by sex. This study aimed to determine whether serum cystatin C, a sensitive marker of kidney function, or sex differences are associated with CAC in patients without CKD. METHODS: We evaluated 456 consecutive patients (61±13 years, 42% women) without CKD and evidence of coronary artery disease...
June 1, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/28572913/hdac9-is-an-epigenetic-repressor-of-kidney-angiotensinogen-establishing-a-sex-difference
#10
Camille T Bourgeois, Ryousuke Satou, Minolfa C Prieto
BACKGROUND: Sexual difference has been shown in the pathogenesis of chronic kidney disease induced by hypertension. Females are protected from hypertension and related end-organ damage. Augmentation of renal proximal tubular angiotensinogen (AGT) expression can promote intrarenal angiotensin formation and the development of associated hypertension and kidney injury. Female rodents exhibit lower intrarenal AGT levels than males under normal conditions, suggesting that the suppressed intrarenal AGT production by programmed mechanisms in females may provide protection from these diseases...
2017: Biology of Sex Differences
https://www.readbyqxmd.com/read/28570715/exhaled-volatile-substances-mirror-clinical-conditions-in-pediatric-chronic-kidney-disease
#11
Juliane Obermeier, Phillip Trefz, Josephine Happ, Jochen K Schubert, Hagen Staude, Dagmar-Christiane Fischer, Wolfram Miekisch
Monitoring metabolic adaptation to chronic kidney disease (CKD) early in the time course of the disease is challenging. As a non-invasive technique, analysis of exhaled breath profiles is especially attractive in children. Up to now, no reports on breath profiles in this patient cohort are available. 116 pediatric subjects suffering from mild-to-moderate CKD (n = 48) or having a functional renal transplant KTx (n = 8) and healthy controls (n = 60) matched for age and sex were investigated. Non-invasive quantitative analysis of exhaled breath profiles by means of a highly sensitive online mass spectrometric technique (PTR-ToF) was used...
2017: PloS One
https://www.readbyqxmd.com/read/28570233/sex-related-differences-in-outcomes-after-percutaneous-balloon-aortic-valvuloplasty
#12
Marzena Daniec, Artur Dziewierz, Danuta Sorysz, Paweł Kleczyński, Tomasz Rakowski, Łukasz Rzeszutko, Jarosław Trębacz, Marek Tomala, Bartłomiej Nawrotek, Krzysztof Żmudka, Dariusz Dudek
OBJECTIVES: We aimed to evaluate sex-related differences in short-term and long-term outcomes of patients undergoing balloon aortic valvuloplasty (BAV) for severe aortic stenosis (AS). METHODS: A total of 112 patients with severe AS underwent 114 BAV procedures as palliative procedure, bridge to definitive treatment, or before urgent non-cardiac surgery. Patients were followed for 24 months. RESULTS: Of the 112 patients, 70 (62.5%) were women...
June 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/28569600/the-associations-among-co-morbidity-cardiac-geometries-and-mechanics-in-hospitalized-heart-failure-with-or-without-preserved-ejection-fraction
#13
Chi-In Lo, Yau-Huei Lai, Sheng-Nan Chang, Jen-Yuan Kuo, Ya-Ching Hsieh, Bernard E Bulwer, Chung-Lieh Hung, Hung-I Yeh
BACKGROUND: The associations among chronic health conditions, ventricular geometric alterations or cardiac contractile mechanics in different phenotypes heart failure (HF) remain largely unexplored. METHODS: We studied 438 consecutive hospitalized patients (mean age: 64.9 ± 16.6 years, 52.5% female) with or without clinical evidence of HF. We examined the associations among clinical co-morbidities, LV geometries and systolic mechanics in terms of global myocardial strains...
2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28542445/dietary-cadmium-exposure-assessment-among-the-chinese-population
#14
Yan Song, Yibana Wang, Weifeng Mao, Haixia Sui, Ling Yong, Dajin Yang, Dingguo Jiang, Lei Zhang, Yunyun Gong
Cadmium, a toxic heavy metal, is widely present in food. It has been reported that chronic cadmium exposure is associated with kidney disease, osteoporosis, cardiovascular disease and cancer. The aim of this study was to assess the dietary cadmium exposure and potential health risk in different age-sex groups of the Chinese population (children aged 4-11 years, young people aged 12-17 years and adults aged over 18 years), and in the southern and northern population using a semi-probabilistic method. Cadmium was detected in 228,687 food samples from 32 food categrories by graphite furnace atomic absorption spectrometry...
2017: PloS One
https://www.readbyqxmd.com/read/28532558/chronic-kidney-disease-gender-and-access-to-care-a-global-perspective
#15
REVIEW
Juan-Jesus Carrero, Manfred Hecking, Ifeoma Ulasi, Laura Sola, Bernadette Thomas
Little is known regarding the ways in which chronic kidney disease (CKD) prevalence and progression differ between the sexes. Still less is known regarding how social disparities between men and women may affect access to care for CKD. In this review, we briefly describe biological sex differences, noting how these differences currently do not influence CKD management recommendations. We then describe what is known within the published literature regarding differences in CKD epidemiology between sexes; namely prevalence, progression, and access to treatment throughout the major world regions...
May 2017: Seminars in Nephrology
https://www.readbyqxmd.com/read/28520811/body-shape-index-sex-specific-differences-in-predictive-power-for-all-cause-mortality-in-the-japanese-population
#16
Yuji Sato, Shouichi Fujimoto, Tsuneo Konta, Kunitoshi Iseki, Toshiki Moriyama, Kunihiro Yamagata, Kazuhiko Tsuruya, Ichiei Narita, Masahide Kondo, Masato Kasahara, Yugo Shibagaki, Koichi Asahi, Tsuyoshi Watanabe
BACKGROUND: While body mass index (BMI) is the most widely used anthropometric measure, its association with all-cause mortality is generally J-shaped or U-shaped. A body shape index (ABSI) is a recently formulated anthropometric measure that shows linear relationship to all-cause mortality, especially in Caucasian cohorts. We aimed to address the relationship between ABSI and all-cause mortality in Asians and to assess the influence of sex difference and of chronic kidney disease (CKD) on this relationship...
2017: PloS One
https://www.readbyqxmd.com/read/28509399/association-of-renin-angiotensin-antagonists-with-adverse-perioperative-events-in-patients-undergoing-elective-orthopaedic-surgery-a-case-control-study
#17
Amith Zainudheen, Ian A Scott, Xenia Caney
BACKGROUND: Renin angiotensin antagonists (RAAs) may block protective vasopressor responses during surgery. Evidence linking RAAs with intraoperative hypotension and perioperative adverse events is conflicting. METHODS: Retrospective case-control study of 258 consecutive patients who underwent elective total knee or hip replacement between January 1(st) 2013 and August 31(st) 2016, and who were chronically prescribed a single blood pressure lowering agent up to the time of surgery...
May 16, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28506691/urinary-lysophopholipids-are-increased-in-diabetic-patients-with-nephropathy
#18
Jean-Sébastien Saulnier-Blache, Eva Feigerlova, Jean Michel Halimi, Pierre Gourdy, Ronan Roussel, Bruno Guerci, Aude Dupuy, Justine Bertrand-Michel, Jean-Loup Bascands, Samy Hadjadj, Joost P Schanstra
Diabetic nephropathy (DN) is a major cause of chronic kidney disease that frequently leads to end stage renal failure. Lysophosphatidic acid (LPA) and lysophosphatidylcholine (LPC) are lysophospholipid mediators shown to accumulate in kidney and to promote renal inflammation and tubulo-interstitial fibrosis in diabetic rodent models. Here we assessed whether LPA and LPC were associated to the development of nephropathy in diabetic human patients. Several molecular species of LPA and LPC were quantified by LC/MS-MS in urine and plasma from type 2 diabetic patients with (cases; n=41) or without (controls, n=41) nephropathy symptoms (micro/macro-albuminuria and eGFR<60ml/min/1...
July 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28505377/performance-of-glomerular-filtration-rate-estimating-equations-in-a-community-based-sample-of-blacks-and-whites-the-multiethnic-study-of-atherosclerosis
#19
Lesley A Inker, Andrew S Levey, Hocine Tighiouart, Tariq Shafi, John H Eckfeldt, Craig Johnson, Aghogho Okparavero, Wendy S Post, Josef Coresh, Michael G Shlipak
Background.: The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations are recommended for glomerular filtration rate (GFR) estimation in the general population. They have not been evaluated in community-based populations, including Blacks at higher levels of GFR, but are commonly applied in such populations. Methods.: In an ancillary study of Multi-Ethnic Study of Atherosclerosis conducted at one site, we evaluated the performance of the CKD-EPI equations for creatinine (eGFRcr), cystatin C (eGFRcys) or the combination (eGFRcr-cys) compared with GFR measured as plasma clearance of iohexol...
May 13, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28498634/older-people-with-type-2-diabetes-including-those-with-chronic-kidney-disease-or-dementia-are-commonly-overtreated-with-sulfonylurea-or-insulin-therapies
#20
C E Hambling, Samuel Seidu, M J Davies, K Khunti
AIM: To evaluate potential overtreatment with sulfonylurea and insulin therapies amongst older people with Type 2 diabetes, including those with chronic kidney disease or dementia. METHODS: Using the ECLIPSE Live software tool, we developed a search to examine data on older people (age ≥ 70 years) with Type 2 diabetes, who were prescribed sulfonylurea or insulin therapies over the previous 90 days. Sixteen Norfolk general practices participated, representing a population of 24 661 older people, including 3862 (15...
May 12, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
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