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Sex differences chronic kidney disease

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https://www.readbyqxmd.com/read/29149237/multimorbidity-among-persons-living-with-hiv-in-the-u-s
#1
Cherise Wong, Stephen J Gange, Richard D Moore, Amy C Justice, Kate Buchacz, Alison G Abraham, Peter F Rebeiro, John R Koethe, Jeffrey N Martin, Michael A Horberg, Cynthia M Boyd, Mari M Kitahata, Heidi M Crane, Kelly A Gebo, M John Gill, Michael J Silverberg, Frank J Palella, Pragna Patel, Hasina Samji, Jennifer Thorne, Charles S Rabkin, Angel Mayor, Keri N Althoff
Background: Age-associated conditions are increasingly common among persons living with HIV. A longitudinal investigation of their accrual is needed given their implications on clinical care complexity. We examined trends in the co-occurrence of age-associated conditions among persons living with HIV receiving clinical care, and differences in their prevalence by demographic subgroup. Methods: This cohort study was nested within the North American AIDS Cohort Collaboration on Research and Design...
November 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29145203/evaluation-of-mental-disorders-using-proton-magnetic-resonance-spectroscopy-in-dialysis-and-predialysis-patients
#2
Chun-Yun Zhang, Ying Chen, Shan Chen, Xiang-Chuang Kong, Yuan Liu, Chao-Qun You, Cheng Wan, Philip A Bondzie, Hua Su, Chun Zhang, Fang-Fang He
BACKGROUND/AIMS: Psychological complications are prevalent in patients with chronic kidney disease (CKD). This study aimed to investigate mental disorders in stage 4-5 CKD patients, to detect metabolite concentrations in the brain by proton magnetic resonance spectroscopy (1H-MRS) and to compare the effects of different dialysis therapies on mental disorders in end-stage renal disease (ESRD). METHODS: The sample population was made up of predialysis (13), hemodialysis (HD) (13), and peritoneal dialysis (PD) patients (12)...
November 21, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29141937/novel-differences-in-renal-gene-expression-in-a-diet-induced-obesity-model
#3
Victoria L Halperin Kuhns, Jennifer L Pluznick
Obesity is a significant risk factor for both chronic kidney disease and end stage renal disease. To better understand disease development, we sought to identify novel genes differentially expressed early in disease progression. We first confirmed that mice fed a high-fat (HF) diet exhibit early signs of renal injury including hyperfiltration. We then performed RNA Seq using renal cortex RNA from C57Bl/6 male mice fed either HF or control (Ctrl) diet. We identified 1134 genes differentially expressed in the cortex on HF versus Ctrl, of which 31 genes were selected for follow up analysis...
November 15, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29130072/prediction-of-chronic-kidney-disease-stage-3-by-ckd273-a-urinary-proteomic-biomarker
#4
Claudia Pontillo, Zhen-Yu Zhang, Joost P Schanstra, Lotte Jacobs, Petra Zürbig, Lutgarde Thijs, Adela Ramírez-Torres, Hiddo J L Heerspink, Morten Lindhardt, Ronald Klein, Trevor Orchard, Massimo Porta, Rudolf W Bilous, Nishi Charturvedi, Peter Rossing, Antonia Vlahou, Eva Schepers, Griet Glorieux, William Mullen, Christian Delles, Peter Verhamme, Raymond Vanholder, Jan A Staessen, Harald Mischak, Joachim Jankowski
Introduction: CKD273 is a urinary biomarker, which in advanced chronic kidney disease predicts further deterioration. We investigated whether CKD273 can also predict a decline of estimated glomerular filtration rate (eGFR) to <60 ml/min per 1.73 m(2). Methods: In analyses of 2087 individuals from 6 cohorts (46.4% women; 73.5% with diabetes; mean age, 46.1 years; eGFR ≥ 60 ml/min per 1.73 m(2), 100%; urinary albumin excretion rate [UAE] ≥20 μg/min, 6.2%), we accounted for cohort, sex, age, mean arterial pressure, diabetes, and eGFR at baseline and expressed associations per 1-SD increment in urinary biomarkers...
November 2017: KI Reports
https://www.readbyqxmd.com/read/29128573/26-week-oral-chronic-toxicity-study-of-geniposide-in-rats
#5
Jingzhuo Tian, Yan Yi, Yong Zhao, Chunying Li, Yushi Zhang, Lianmei Wang, Chen Pan, Jiayin Han, Guiqin Li, Xiaolong Li, Jing Liu, Nuo Deng, Yue Gao, Aihua Liang
ETHNOPHARMACOLOGICAL RELEVANCE: Geniposide, the major active constituent of Fructus Gardeniae (FG), has been widely used to treat the various diseases in China. AIM OF THE STUDY: The chronic toxicity study was conducted to investigate the safety of Geniposide. MATERIALS AND METHODS: Sprague-Dawley (SD) rats of both sexes were administered orally Geniposide 25, 50, 100mg/kg by gavage once daily at volume of 10mL/kg for 26 weeks repeated. Endpoints evaluated included clinical observations, food consumption, body weights, blood biochemistry, hematology, and histomorphological observation...
November 8, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29120587/matrix-metalloproteinase-2-and-osteoprotegrin-as-new-markers-of-increased-atherosclerotic-risk-in-egyptian-patients-with-chronic-kidney-disease
#6
Amany M Elsaeed, Amal H Ibrahiem, Asmaa A Ali
The prevalence of chronic kidney disease (CKD) is rising continuously. Cardiovascular disease (CVD) is among the leading causes of death and premature mortality of patients with CKD. It has been suggested that the assessment of CKD-associated CVD risk factors together with conventional risk factors should be performed in order to improve the prediction of coronary heart disease risk. The reduction of these factors seems to be effective in lowering cardiovascular (CV) morbidity and mortality in patients with CKD...
January 2017: Egyptian Journal of Immunology
https://www.readbyqxmd.com/read/29110801/enhanced-electrical-field-stimulated-nitrergic-and-purinergic-vasoreactivity-in-distal-vs-proximal-internal-pudendal-arteries
#7
Michael R Odom, Elena S Pak, David A Brown, Johanna L Hannan
BACKGROUND: The internal pudendal arteries (IPAs) supply blood to the penis and are highly susceptible to vascular remodeling in rodent models of diabetes, hypertension, aging, and chronic kidney disease, thus contributing to erectile dysfunction. Interestingly, vascular remodeling primarily occurs in the distal and not in the proximal IPA, suggesting distinct local physiologic signaling differences within the IPA. AIM: To examine the role of purinergic signaling and neurotransmitter release by electrical field stimulation (EFS) in the regulation of proximal and distal IPA vascular tone...
November 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29109861/association-of-smoking-with-prevalence-of-common-diseases-and-metabolic-abnormalities-in-community-dwelling-japanese-individuals
#8
Chikara Ueyama, Hideki Horibe, Yuichiro Yamase, Tetsuo Fujimaki, Mitsutoshi Oguri, Kimihiko Kato, Yoshiji Yamada
Smoking is a significant risk factor for cardiovascular diseases (CVDs). Given that certain common pathologies, including hypertension, dyslipidemia and type 2 diabetes mellitus, are major risk factors for CVDs, the association of smoking with CVDs may be attributable, at least in part, to its effects on common diseases. The aim of the present study was to determine the association of smoking with the prevalence of common diseases and metabolic abnormalities in community-dwelling Japanese individuals. The study included 5,959 subjects (1,302 current smokers, 1,418 past smokers and 3,239 nonsmokers) recruited to the Inabe Health and Longevity Study, a longitudinal genetic epidemiological study of atherosclerotic, cardiovascular and metabolic diseases...
November 2017: Biomedical Reports
https://www.readbyqxmd.com/read/29106471/kidney-function-modifies-the-selection-of-treatment-strategies-and-long-term-survival-in-stable-ischemic-heart-disease-insights-from-the-alberta-provincial-project-for-outcomes-assessment-in-coronary-heart-disease-approach-registry
#9
Jay S Shavadia, Danielle A Southern, Matthew T James, Robert C Welsh, Kevin R Bainey
Aims: Patients with chronic kidney disease (CKD) have been under-represented in stable ischemic heart disease (SIHD) trials despite their heightened risk of cardiovascular mortality. We examine associations between kidney disease, treatment selection, and long-term survival in patients with SIHD. Methods and Results: SIHD patients with angiographically significant stenosis (≥70%) were categorized by renal function (dialysis-dependent, severe CKD [eGFR<30], mild-moderate CKD [eGFR30-59] and no CKD [eGFR≥60]), and by treatment groups (revascularization ≤ 3 months of angiogram [CABG or PCI] versus medical therapy)...
November 2, 2017: European Heart Journal. Quality of Care & Clinical Outcomes
https://www.readbyqxmd.com/read/29082816/pilot-study-to-evaluate-the-potential-use-of-the-renal-resistive-index-as-a-preliminary-diagnostic-tool-for-chronic-kidney-disease-in-cats
#10
Ines Matos, Pedro Azevedo, L Miguel Carreira
Objectives Chronic kidney disease (CKD) is the most common renal pathology diagnosed in geriatric cats, and its prevalence increases with age. The arterial resistive index (RI) is important when evaluating vascular resistance and compliance, and can be applied in the kidney (renal RI [RRI]), allowing the evaluation of its vascular haemodynamics. The present study aimed to: (1) investigate in cats with CKD the relationships between the RRI and the following parameters: age, sex, body weight, plasmatic creatinine, blood urea nitrogen, potassium, urine specific gravity, urine protein:creatinine ratio, systolic arterial pressure; and (2) evaluate the potential use of the RRI as a preliminary diagnostic tool in cats with CKD...
October 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28969115/study-of-red-cell-fragility-in-different-stages-of-chronic-kidney-disease-in-relation-to-parathyroid-hormone
#11
Suchismita Panda, Anuva Mishra, Manoranjan Jena, Sashi Bhusan Rout, Srikrushna Mohapatra
INTRODUCTION: Anaemia is one of the common complications associated with Chronic Kidney Disease (CKD) responsible for the increase in the morbidity and mortality in such patients. Several factors have been attributed to cause renal anaemia, amongst which hyperparathyroidism is one of the less recognised reasons. Most studies have been conducted in this regard in CKD patients undergoing haemodialysis. The level of PTH in early stages of chronic kidney disease has not been much studied...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28957410/the-association-between-the-apolipoprotein-b-a-i-ratio-and-coronary-calcification-may-differ-depending-on-kidney-function-in-a-healthy-population
#12
Seok-Hyung Kim, Donghwan Oh, Kwon Soo Jung, Jung Eun Lee, Hyunwook Kim, Hyung Jong Kim, Beom Seok Kim, Hyeong Cheon Park, Byoung Kwon Lee, Hoon Young Choi
BACKGROUND: The apolipoprotein B/A-1 ratio has been reported to be one of the strongest risk predictors of cardiovascular events. However, its prognostic value for cardiovascular disease is still uncertain, especially in patients with chronic kidney disease. This study aimed to investigate whether the association between the apolipoprotein B/A-I ratio and coronary artery calcification differed according to kidney function in a healthy population. METHODS: Of the data from 7,780 participants from the medical records database in Gangnam Severance Hospital from 2005 through 2016, a cross-sectional analysis included participants with an estimated glomerular filtration rate (eGFR) ≥ 60 mL/min/1...
2017: PloS One
https://www.readbyqxmd.com/read/28935359/disparities-by-sex-tracked-in-the-2015-national-healthcare-quality-and-disparities-report-trends-across-national-quality-strategy-priorities-health-conditions-and-access-measures
#13
Jennifer E Moore, Atlang Mompe, Ernest Moy
INTRODUCTION: Established by the Affordable Care Act, the National Quality Strategy (NQS) is the national policy goals aimed at improving the quality of health care for all Americans. The NQS established six priorities to provide better, more affordable care for individuals and communities. This is the first analysis of data on the NQS and access measures that focus on sex differences, health conditions, trends, and disparities. METHODS: Measures from the 2015 National Healthcare Quality and Disparities Report (QDR) for the four National Quality Strategy priorities (Patient Safety, Person Centered Care, Effective Treatment and Healthy Living), access to care, and health conditions for women were compared to measures for men...
September 19, 2017: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/28931350/sex-differences-in-associations-of-cardio-ankle-vascular-index-with-left-ventricular-function-and-geometry
#14
Zi Ye, Patricia A Pellikka, Iftikhar J Kullo
The cardio-ankle vascular index (CAVI) is a measure of global arterial stiffness. We hypothesized that CAVI is associated with left ventricular (LV) function and geometry in individuals without structural heart disease. We measured CAVI in 600 participants (mean age 60.3±14.6 years, 54% men) without history of atherosclerotic cardiovascular disease who were referred for transthoracic echocardiography. Linear regression analysis was used to assess the association of CAVI with LV function (peak mitral annular systolic s' and early diastolic velocity e') and structure (LV mass index (LVMI) and relative wall thickness (RWT))...
September 1, 2017: Vascular Medicine
https://www.readbyqxmd.com/read/28899568/long-term-survival-after-acute-kidney-injury-following-ruptured-abdominal-aortic-aneurysm-repair
#15
Hamid Jalalzadeh, Reza Indrakusuma, Liffert Vogt, Sytse C van Beek, Anco C Vahl, Willem Wisselink, Mark J W Koelemay, Ron Balm
OBJECTIVE: Acute kidney injury (AKI) is a major complication of ruptured abdominal aortic aneurysm (RAAA). Severe AKI is associated with high morbidity and mortality in the short term. The objective of this study was to determine the association between AKI after RAAA repair and long-term survival. METHODS: We conducted a retrospective cohort study of all patients undergoing RAAA repair in three hospitals between 2004 and 2011. Outcomes were long-term survival after RAAA repair, incidence of postoperative AKI, and chronic dialysis rates...
September 9, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28878300/white-coat-and-masked-hypertension-are-associated-with-albuminuria-in-a-general-population-the-hisayama-study
#16
Jun Hata, Masayo Fukuhara, Satoko Sakata, Hisatomi Arima, Yoichiro Hirakawa, Koji Yonemoto, Naoko Mukai, Takanari Kitazono, Yutaka Kiyohara, Toshiharu Ninomiya
Epidemiological and clinical studies have investigated the influence of hypertension on chronic kidney disease (CKD), but limited data are available for the associations of white-coat hypertension (WCHT), masked hypertension (MHT) and sustained hypertension (SHT) with kidney dysfunction in general populations. We examined the associations of these types of hypertension with CKD (albuminuria and reduction in estimated glomerular filtration rate (eGFR)) in a cross-sectional survey of 2974 community-dwelling Japanese aged ⩾40 years...
November 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/28864484/lifetime-risks-of-kidney-donation-a-medical-decision-analysis
#17
Bryce A Kiberd, Karthik K Tennankore
OBJECTIVE: This study estimated the potential loss of life and the lifetime cumulative risk of end-stage renal disease (ESRD) from live kidney donation. DESIGN: Markov medical decision analysis. SETTING: USA. PARTICIPANTS: 40-year-old live kidney donors of both sexes and black/white race. INTERVENTION: Live donor nephrectomy. MAIN OUTCOME AND MEASURES: Potential remaining life years lost, quality-adjusted life years (QALYs) lost and added lifetime cumulative risk of ESRD from donation...
September 1, 2017: BMJ Open
https://www.readbyqxmd.com/read/28853062/adjusting-health-spending-for-the-presence-of-comorbidities-an-application-to-united-states-national-inpatient-data
#18
Joseph L Dieleman, Ranju Baral, Elizabeth Johnson, Anne Bulchis, Maxwell Birger, Anthony L Bui, Madeline Campbell, Abigail Chapin, Rose Gabert, Hannah Hamavid, Cody Horst, Jonathan Joseph, Liya Lomsadze, Ellen Squires, Martin Tobias
BACKGROUND: One of the major challenges in estimating health care spending spent on each cause of illness is allocating spending for a health care event to a single cause of illness in the presence of comorbidities. Comorbidities, the secondary diagnoses, are common across many causes of illness and often correlate with worse health outcomes and more expensive health care. In this study, we propose a method for measuring the average spending for each cause of illness with and without comorbidities...
August 29, 2017: Health Economics Review
https://www.readbyqxmd.com/read/28842286/incidence-and-risk-factors-of-acute-kidney-injury-in-the-japanese-trauma-population-a-prospective-cohort-study
#19
Jun Fujinaga, Akira Kuriyama, Noriaki Shimada
INTRODUCTION: Previous studies have reported the prevalence and risk factors of acute kidney injury (AKI) in relatively young trauma patients. The aims of this study were to identify the prevalence and risk factors of AKI among older Japanese trauma patients. METHODS: We conducted a prospective observational study in the 8-bed intensive care unit (ICU) of a Japanese tertiary-care hospital. Participants comprised trauma patients aged 18 years or older admitted to the ICU...
August 15, 2017: Injury
https://www.readbyqxmd.com/read/28833526/perinatal-lead-pb-exposure-results-in-sex-and-tissue-dependent-adult-dna-methylation-alterations-in-murine-iap-transposons
#20
L Montrose, C Faulk, J Francis, D C Dolinoy
Epidemiological and animal data suggest that adult chronic disease is influenced by early-life exposure-induced changes to the epigenome. Previously, we observed that perinatal lead (Pb) exposure results in persistent murine metabolic- and activity-related effects. Using phylogenetic and DNA methylation analysis, we have also identified novel intracisternal A particle (IAP) retrotransposons exhibiting regions of variable methylation as candidate loci for environmental effects on the epigenome. Here, we now evaluate brain and kidney DNA methylation profiles of four representative IAPs in adult mice exposed to human physiologically relevant levels of Pb two weeks prior to mating through lactation...
October 2017: Environmental and Molecular Mutagenesis
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