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https://www.readbyqxmd.com/read/28210651/analysis-of-platelet-rich-plasma-extraction-variations-in-platelet-and-blood-components-between-4-common-commercial-kits
#1
Jane Fitzpatrick, Max K Bulsara, Paul Robert McCrory, Martin D Richardson, Ming Hao Zheng
BACKGROUND: Platelet-rich plasma (PRP) has been extensively used as a treatment in tissue healing in tendinopathy, muscle injury, and osteoarthritis. However, there is variation in methods of extraction, and this produces different types of PRP. PURPOSE: To determine the composition of PRP obtained from 4 commercial separation kits, which would allow assessment of current classification systems used in cross-study comparisons. STUDY DESIGN: Controlled laboratory study...
January 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28199931/a-personalized-3d-printed-prosthetic-joint-replacement-for-the-human-temporomandibular-joint-from-implant-design-to-implantation
#2
David C Ackland, Dale Robinson, Michael Redhead, Peter Vee Sin Lee, Adrian Moskaljuk, George Dimitroulis
Personalized prosthetic joint replacements have important applications in cases of complex bone and joint conditions where the shape and size of off-the-shelf components may not be adequate. The objective of this study was to design, test and fabricate a personalized 3D-printed prosthesis for a patient requiring total joint replacement surgery of the temporomandibular joint (TMJ). The new 'Melbourne' prosthetic TMJ design featured a condylar component sized specifically to the patient and fixation screw positions that avoid potential intra-operative damage to the mandibular nerve...
February 6, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28194713/use-of-compressive-osseointegration-endoprostheses-for-massive-bone-loss-from-tumor-and-failed-arthroplasty-a-viable-option-in-the-upper-extremity
#3
Krista A Goulding, Adam Schwartz, Steven J Hattrup, R Lor Randall, Donald Lee, Damian M Rispoli, Daniel M Lerman, Christopher Beauchamp
BACKGROUND: Endoprostheses using principles of compressive osseointegration have shown good survivorship in several studies involving the lower extremity; however, no series to our knowledge have documented the use of this technology in the management of massive bone loss in the upper limb. QUESTIONS/PURPOSES: (1) What proportion of upper extremity implants using compressive osseointegration fixation principles achieved durable short-term fixation, and what were the modes of failure? (2) What surgical complications resulted from reconstruction using this technique? METHODS: A multiinstitutional retrospective review identified nine patients (five women; four men) who underwent 13 endoprosthetic replacements between 2003 and 2014 using compressive osseointegration (Compliant(®) Pre-stress Device [CPS]; Biomet Inc, Warsaw, IN, USA) in the upper extremity, including two proximal humeri, two humeral diaphyses, seven distal humeri, and two proximal ulna...
February 13, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28167878/commercial-separation-systems-designed-for-preparation-of-platelet-rich-plasma-yield-differences-in-cellular-composition
#4
Ryan M Degen, Johnathan A Bernard, Kristin S Oliver, Joshua S Dines
BACKGROUND: The role of platelet-rich plasma (PRP) in the treatment of sport-related injuries is unclear, largely due to the heterogeneity of clinical results. This may relate to compositional differences in PRP from different separation systems. QUESTIONS/PURPOSES: This study aims to compare the composition of PRP produced with five different commercially available systems, focusing on cellular concentrations and pH. METHODS: Seven donors (41 ± 12 years) provided blood for PRP preparation using five systems (Arthrex Angel, Emcyte Genesis CS, Arteriocyte Magellan, Harvest SmartPrep, and Biomet GPS III)...
February 2017: HSS Journal: the Musculoskeletal Journal of Hospital for Special Surgery
https://www.readbyqxmd.com/read/28167489/mechanical-properties-of-all-suture-anchors-for-rotator-cuff-repair
#5
N S Nagra, N Zargar, R D J Smith, A J Carr
OBJECTIVES: All-suture anchors are increasingly used in rotator cuff repair procedures. Potential benefits include decreased bone damage. However, there is limited published evidence for the relative strength of fixation for all-suture anchors compared with traditional anchors. MATERIALS AND METHODS: A total of four commercially available all-suture anchors, the 'Y-Knot' (ConMed), Q-FIX (Smith & Nephew), ICONIX (Stryker) and JuggerKnot (Zimmer Biomet) and a traditional anchor control TWINFIX Ultra PK Suture Anchor (Smith & Nephew) were tested in cadaveric human humeral head rotator cuff repair models (n = 24)...
February 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28137443/extra-articular-subcutaneous-inverted-king-post-truss-ligament-reconstruction-for-severe-swan-neck-deformity-snapping-finger
#6
X de Soras, P de Mourgues, P Pradel, J-P Urien, E Beaudoin
A swan neck deformity (SND) can be well tolerated for a long time, until the appearance of a disabling "snapping finger". In its most advanced condition, the other hand is needed to initiate finger flexion. We propose a technique of extra-articular, subcutaneous ligament reconstruction with an "inverted king post-truss" configuration use in roofs and to reinforce railway bridges. An artificial ligament (MaxBraid™ polyethylene surgical suture, 5 metric, Biomet) makes a figure of eight between transosseous tunnels in the proximal and middle phalanges, crossing over top of the A3 pulley...
February 2017: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/28130351/repeatability-and-agreement-of-ocular-biometry-measurements-aladdin-versus-lenstar
#7
Colm McAlinden, Rongrong Gao, Ayong Yu, Xiaorui Wang, Jing Yang, Ye Yu, Hao Chen, Qinmei Wang, Jinhai Huang
OBJECTIVE: To assess the repeatability and agreement between the Aladdin and Lenstar biometers. METHODS: Three consecutive measurements of the right eye of 102 subjects were acquired by the Aladdin (V.1.1.3) and the Lenstar (V.1.0.3), respectively, with a random order of which biometer to use first. Parameters compared included axial length (AL), anterior chamber depth (ACD), flat keratometry (Kf), steep keratometry (Ks), mean keratometry (Km), J0, J45 and white-to-white (WTW) distance...
January 27, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28119449/in-vivo-modelling-of-the-pathogenic-effect-of-copper-transporter-mutations-that-cause-menkes-and-wilson-disease-motor-neuropathy-and-susceptibility-to-alzheimer-s-disease
#8
Stephen W Mercer, Jianbin Wang, Richard Burke
Copper is an essential biometal and several inherited diseases are directly associated with a disruption to normal copper homeostasis. The best characterised are the copper deficiency and toxicity disorders Menkes and Wilson disease, caused by mutations in the p-Type Cu-ATPase genes ATP7A and ATP7B respectively. Missense mutations in the C-terminal portion of ATP7A have also been shown to cause Distal Motor Neuropathy while polymorphisms in ATP7B are associated with increased risk of Alzheimer's disease. We have generated a single, in vivo model for studying multiple pathogenic mutations in ATP7 proteins, using Drosophila melanogaster, which has a single orthologue of ATP7A and ATP7B...
January 24, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28096459/zinc-and-copper-differentially-modulate-amyloid-precursor-protein-processing-by-%C3%AE-secretase-and-amyloid-%C3%AE-peptide-production
#9
Hermeto Gerber, Fang Wu, Mitko Dimitrov, Guillermo M Garcia Osuna, Patrick C Fraering
Recent evidence suggests involvement of biometal homeostasis in the pathological mechanisms in Alzheimer's disease (AD). For example, increased intracellular copper or zinc has been linked to a reduction in secreted levels of the AD-causing amyloid-β peptide (Aβ). However, little is known about whether these biometals modulate the generation of Aβ. In the present study, we demonstrate in both cell-free and cell-based assays that zinc and copper regulate Aβ production by distinct molecular mechanisms affecting the processing by γ-secretase of its Aβ precursor protein substrate APP-C99...
January 17, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28072898/three-year-results-with-a-ringless-third-generation-porous-plasma-sprayed-acetabular-component-in-primary-total-hip-arthroplasty
#10
Keith R Berend, Joanne B Adams, Michael J Morris, Adolph V Lombardi
INTRODUCTION: We previously reported promising early results in patients undergoing primary total hip arthroplasty (THA) with a third-generation cementless acetabular system that has a porous plasma-sprayed coating on a titanium alloy substrate shell, a ringless barb and groove locking mechanism, and a vitamin E-infused highly crosslinked polyethylene insert. The purpose of this study was to examine the outcomes and need for revision in a subset of patients previously reviewed who now have potential for three-year follow-up...
January 10, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/28060023/impact-of-second-stage-surgery-on-bone-remodeling-around-new-hybrid-titanium-implants-a-prospective-clinical-study-in-humans
#11
Tonino Traini, Marco Berardini, Francesca Congedi, Bruna Sinjari, Paolo Trisi, Sergio Caputi
OBJECTIVE: The present prospective study aimed to more precisely identify the time points of bone changes around hybrid titanium implants up to 30 months of follow-up. MATERIALS AND METHODS: Twelve hybrid T3 implants (Biomet 3i) were placed in 9 healthy patients with the 2-stage surgical approach. Standardized digital Rx were taken at implant insertion (T0); healing-abutment connection after 3.1 ± 0.2 weeks (TX); loading stage after 7.5 ± 0.6 weeks (T1); after 12 months (T2); and after 30 months (T3) of functional loading...
February 2017: Implant Dentistry
https://www.readbyqxmd.com/read/28050321/comparison-of-anterior-segment-measurements-obtained-by-aladdin-optical-biometer-and-sirius-corneal-topography
#12
Onur Polat, Zeki Baysal, Serkan Özcan, Sibel İnan, Ümit Übeyt İnan
OBJECTIVES: To assess the agreement of anterior segment parameter measurements derived from Aladdin optical biometer using optical low coherence interferometer and Sirius corneal topography using combined Scheimpflug-Placido disk. MATERIALS AND METHODS: Data obtained using the Aladdin and Sirius systems from 110 eyes of 59 subjects who had no health problems other than refractive errors were retrospectively evaluated. Anterior chamber depth (ACD), flat (K1) and steep (K2) keratometry readings, and white-to-white distance (WTW) measurements taken with both devices were noted...
December 2016: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28011206/design-synthesis-and-biological-evaluation-of-4-aminochalcone-rivastigmine-hybrids-as-multifunctional-agents-for-the-treatment-of-alzheimer-s-disease
#13
Ganyuan Xiao, Yan Li, Xiaoming Qiang, Rui Xu, Yunxiaozhu Zheng, Zhongcheng Cao, Li Luo, Xia Yang, Zhipei Sang, Fu Su, Yong Deng
A series of 4'-aminochalcone-revastigmine hybrids were designed, synthesized and evaluated as multifunctional agents for the treatment of Alzheimer's disease. The results showed that most of these compounds exhibited good multifunctional activities. In particular, compound 6c displayed the best inhibitory potency on acetylcholinesterase (IC50=4.91μM), and significant antioxidative activity with a value 2.83-fold of Trolox. The kinetic analysis of AChE inhibition revealed that 6c showed mixed-type inhibition, binding simultaneously to the catalytic active site and peripheral anionic site of AChE...
December 9, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28007638/immunotoxicological-effects-of-arsenic-bioaccumulation-on-spatial-metallomics-and-cellular-enzyme-response-in-the-spleen-of-male-wistar-rats-after-oral-intake
#14
Elio A Soria, Roberto D Pérez, Ignasi Queralt, Carlos A Pérez, Guillermina A Bongiovanni
Arsenic (As) is a worldwide environmental contaminant, which compromises immunity and causes various associated disorders. To further investigate its immunotoxicity, male Wistar rats were exposed to 100ppm of sodium arsenite (inorganic AsIII) in drinking water for 2 months. Given that metals are significant immune regulators, their content and distribution were analysed in spleen tissues, to then evaluate subsequent changes of redox enzyme responses in spleen parenchyma cells (splenocytes). X-ray fluorescence spectrometry demonstrated As accumulation in both white and red pulps (p<0...
January 15, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/27999295/special-issue-molecules-against-alzheimer
#15
EDITORIAL
Michael Decker, Diego Muñoz-Torrero
This Special Issue, entitled "Molecules against Alzheimer", gathers a number of original articles, short communications, and review articles on recent research efforts toward the development of novel drug candidates, diagnostic agents and therapeutic approaches for Alzheimer's disease (AD), the most prevalent neurodegenerative disorder and a leading cause of death worldwide. This Special Issue contains many interesting examples describing the design, synthesis, and pharmacological profiling of novel compounds that hit one or several key biological targets, such as cholinesterases, β-amyloid formation or aggregation, monoamine oxidase B, oxidative stress, biometal dyshomeostasis, mitochondrial dysfunction, serotonin and/or melatonin systems, the Wnt/β-catenin pathway, sigma receptors, nicotinamide phosphoribosyltransferase, or nuclear erythroid 2-related factor...
December 16, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27994390/comparison-of-anterior-segment-measurements-with-optical-low-coherence-reflectometry-and-partial-coherence-interferometry-optical-biometers
#16
Ertuğrul Can, Mustafa Duran, Tuğba Çetinkaya, Nurşen Arıtürk
AIMS: To evaluate a new noncontact optical biometer using partial-coherence interferometry and to compare the clinical measurements with those obtained from the device using optical low-coherence reflectometry (OLCR). SETTING AND DESIGN: Ondokuz Mayis University, Samsun, Turkey. Nonrandomized, prospective clinical trial. SUBJECTS AND METHODS: The study was performed on the healthy phakic eyes of volunteers in the year 2014. Measurements of axial length (AL), anterior chamber depth (ACD), central corneal thickness (CCT), mean keratometry (K), and white-to-white (WTW) measurements obtained with the low-time coherence interferometry (LTCI) were compared with those obtained with the OLCR...
October 2016: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/27951485/aurone-mannich-base-derivatives-as-promising-multifunctional-agents-with-acetylcholinesterase-inhibition-anti-%C3%AE-amyloid-aggragation-and-neuroprotective-properties-for-the-treatment-of-alzheimer-s-disease
#17
Yan Li, Xiaoming Qiang, Li Luo, Xia Yang, Ganyuan Xiao, Qi Liu, Jiachen Ai, Zhenghuai Tan, Yong Deng
A series of aurone Mannich base derivatives were designed, synthesized and evaluated as multifunctional agents for the treatment of Alzheimer's disease. In vitro assays demonstrated that most of the derivatives were selective AChE inhibitors with good multifunctional properties. Among them, compound 7d exhibited outstanding inhibitory activity for RatAChE, EeAChE and HuAChE (IC50 = 0.00878 ± 0.0002 μM, 0.0212 ± 0.006 μM and 0.0371 ± 0.004 μM, respectively). Moreover, 7d displayed high antioxidant activity and could confer significant neuroprotective effect against H2O2-induced PC-12 cell injury...
December 5, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27924742/dual-mobility-total-hip-replacement-in-a-high-risk-population
#18
Jatinder Singh Luthra, Amur Al Riyami, Mohamad Kasim Allami
OBJECTIVE: The purpose of the study was to evaluate results of dual mobility total replacement in a high risk population who take hip into hyperflexed position while sitting and praying on the floor. METHOD: The study included 65 (35 primary total replacement and 30 complex total hip replacement) cases of total hip replacement using avantage privilege dual mobility cup system from biomet. A cemented acetabular component and on femoral side a bimetric stem, either cemented or uncemented used depending on the canal type...
2016: SICOT-J
https://www.readbyqxmd.com/read/27923535/multitarget-drug-design-strategy-against-alzheimer-s-disease-homoisoflavonoid-mannich-base-derivatives-serve-as-acetylcholinesterase-and-monoamine-oxidase-b-dual-inhibitors-with-multifunctional-properties
#19
Yan Li, Xiaoming Qiang, Li Luo, Xia Yang, Ganyuan Xiao, Yunxiaozhu Zheng, Zhongcheng Cao, Zhipei Sang, Fu Su, Yong Deng
A series of homoisoflavonoid Mannich base derivatives were designed, synthesized and evaluated as multifunctional agents against Alzheimer's disease. It demonstrated that most of the derivatives were selective AChE and MAO-B dual inhibitors with good multifunctional properties. Among them, compound 10d displayed the comprehensive advantages, with excellent AChE and MAO-B inhibitory activities (IC50=2.49±0.08nM and 1.74±0.0581μM, respectively), good self- and Cu(2+)-induced Aβ1-42 aggregation inhibitory potency, antioxidant activity, biometal chelating ability and high BBB permeability...
January 15, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/27900479/evaluation-of-the-repeatability-of-a-swept-source-ocular-biometer-for-measuring-ocular-biometric-parameters
#20
Teresa Ferrer-Blasco, Alberto Domínguez-Vicent, José J Esteve-Taboada, Miguel A Aloy, Jose E Adsuara, Robert Montés-Micó
PURPOSE: The purpose was to evaluate the repeatability of a new swept-source optical biometer for measuring ocular biometric parameters. METHODS: Thirty subjects with healthy and phakic eyes were included in this study, and only one eye per participant was analysed. Each eye was measured five times with the IOLMaster 700 swept-source optical biometer (Carl Zeiss Meditec, Jena, Germany). Axial length (AL), anterior chamber depth (ACD), central corneal thickness (CCT), lens thickness (LT), white-to-white (WTW), and K1 and K2 keratometric readings were evaluated...
February 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
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