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https://www.readbyqxmd.com/read/28521479/association-between-non-melanoma-and-melanoma-skin-cancer-rates-vitamin-d-and-latitude
#1
Miguel Rivas, Elisa Rojas, Gloria M Calaf, Marcela Barberán, Claudio Liberman, Marcelo De Paula Correa
Vitamin D synthesis takes place in the skin due to solar ultraviolet-B (UVB) radiation. Several studies have shown the association between low sun exposure, non-melanoma skin cancer (NMSC) and a lack of vitamin D synthesis. Since such synthesis in the body depends on the exposure of the skin to solar UVB radiation (290-320 nm), experimental measurements of this type of solar radiation are important. Tarapaca University in Arica, Chile, established a solar UV radiation laboratory in 2006 and since then this laboratory has performed systematic experimental solar UVB measurements using a calibrated biometer instrument...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28502536/results-of-a-modular-revision-system-in-total-knee-arthroplasty
#2
David A Crawford, Keith R Berend, Michael J Morris, Joanne B Adams, Adolph V Lombardi
BACKGROUND: Revision total knee arthroplasty (TKA) poses unique challenges compared with primary TKA such as bone loss, deformity, and ligament instability. Modular component options allow flexibility to deal with these complexities. The purpose of this study was to evaluate midterm outcomes for revision TKA using a modular revision knee system with complete interchangeability and multiple options for augmentation, offset, constraint, and stem extensions. METHODS: A query of our practice registry revealed 257 consented patients (274 knees and 278 TKA) with minimum 2-year follow-up who underwent aseptic revision TKA with a modular system (Vanguard Super Stabilized Knee; Zimmer Biomet, Warsaw, IN) between 2005 and 2013...
April 10, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28500578/the-relationship-between-copper-iron-and-selenium-levels-and-alzheimer-disease
#3
Felipe Nathanael Coelho Vaz, Bárbara Luisa Fermino, Maria Vaitsa Loch Haskel, Jéssica Wouk, Guilherme Barroso Langoni de Freitas, Roberta Fabbri, Erik Montagna, João Batista Teixeira Rocha, Juliana Sartori Bonini
This study aimed to evaluate the concentrations of copper, iron, and selenium in elderly people with Alzheimer disease (AD), comparing the same parameters in a paired group of healthy people, in order to verify if the amount of these metals may influence the cognitive impairment progression. Patients' cognitive impairment was evaluated by Clinical Dementia Rating (CDR). The elementary quantification of erythrocytes was performed by inductively coupled plasma mass spectrometry technique. The statistical analyses were carried out by SPSS software 20...
May 13, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28481387/trapeziectomy-with-ligament-reconstruction-and-tendon-interposition-versus-a-trapeziometacarpal-prosthesis-for-the-treatment-of-thumb-basal-joint-osteoarthritis
#4
María José Robles-Molina, Francisco López-Caba, Rafael C Gómez-Sánchez, Encarnación Cárdenas-Grande, Miguel Pajares-López, Pedro Hernández-Cortés
Numerous surgical procedures have been described to treat trapeziometacarpal osteoarthritis, but no approach is currently considered superior. Good long-term outcomes have been reported with multiple procedures. No studies have been published comparing outcomes of the Arpe joint replacement (Biomet, Valence, France) with those of ligament reconstruction and tendon interposition (LRTI) using the Burton-Pellegrini technique. The study objective was to compare clinical outcomes between these techniques. Sixty-five patients with Eaton stage III osteoarthritis of the thumb were included in this retrospective follow-up study...
May 8, 2017: Orthopedics
https://www.readbyqxmd.com/read/28476062/patient-reported-outcomes-following-single-and-multiple-radius-total-knee-replacement-a-randomized-controlled-trial
#5
Nadeem Mushtaq, Alexander D Liddle, David Isaac, Katherine Dillow, Paul Gill
Although single-radius (SR) designs of total knee replacement (TKR) have theoretical benefits, the clinical advantage conferred by such designs is unknown. The aim of this randomized, controlled study was to compare the short-term clinical outcomes of the two design rationales. A total of 105 knees were randomized to receive either a single radius (Scorpio, Stryker; SR Group) or multiple radius (AGC, Zimmer Biomet; MR group) TKR. Patient-reported outcomes (Oxford Knee Score [OKS] and Knee Society Score [KSS]) were collected at 6 weeks, 6 months, and 1 year following surgery...
May 5, 2017: Journal of Knee Surgery
https://www.readbyqxmd.com/read/28471917/radial-neck-dilatory-remodeling-following-radial-head-arthroplasty-with-an-uncemented-press-fit-fully-chemically-etched-stem-design
#6
Matthew P Sullivan, Reza Firoozabadi, Stephen A Kennedy, Julie Agel, Eric Magnusson, Brett Schiffman, Matthew Folchert, Daphne Beingessner
OBJECTIVES: To compare the radiographic outcomes of two widely used side loading, press fit, radial head arthroplasty implants used to reconstruct complex elbow trauma. DESIGN: Retrospective cohort study SETTING:: Level 1 Academic trauma center PARTICIPANTS:: Patients undergoing radial head arthroplasty INTERVENTION:: Cohort 1 received Synthes Radial Head Prosthesis. Cohort 2 received Biomet ExploR Radial Head Replacement. MAIN OUTCOME MEASUREMENTS: Radial neck dilatory remodeling RESULTS:: 82 subjects were included in final analysis, 63 from the Biomet Cohort and 19 from Synthes cohort...
April 27, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28461737/comparison-of-the-biometric-measurements-calculated-with-zeiss-iol-master-and-wavelight-ob-820
#7
Georgios Labiris, Panagiota Ntonti, Konstantinos Ntitsos, Andreas Katsanos, Haris Sideroudi, Vasilios Kozobolis
BACKGROUND: The primary objective of this study was to investigate the level of agreement between IOL-Master and OB-820 ocular biometers. MATERIALS AND METHODS: In this prospective randomized case series, we measured the anterior chamber depth (ACD), the axial length (AL), the corneal radii (R1, R2), the ratio of mean corneal radius and spherical equivalent and the corneal astigmatism (cylinder [Cyl]) before and after cataract extraction surgery. RESULTS: Significant differences between pre- and postoperative data were observed for ACD for both biometric devices (P<0...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28458136/design-synthesis-and-evaluation-of-scutellarein-o-acetamidoalkylbenzylamines-as-potential-multifunctional-agents-for-the-treatment-of-alzheimer-s-disease
#8
Zhipei Sang, Xiaoming Qiang, Yan Li, Rui Xu, Zhongcheng Cao, Qing Song, Ting Wang, Xiaoyu Zhang, Hongyan Liu, Zhenghuai Tan, Yong Deng
A series of scutellarein-O-acetamidoalkylbenzylamines derivatives were designed based on a multitarget-directed ligands strategy for the treatment of Alzheimer's disease. Among these compounds, compound T-22 demonstrated excellent acetylcholinesterase inhibitory, moderate inhibitory effects on self-induced Aβ1-42 aggregation, Cu(2+)-induced Aβ1-42 aggregation, human AChE-induced Aβ1-40 aggregation and disassembled Cu(2+)-induced aggregation of the well-structured Aβ1-42 fibrils, and also acted as potential antioxidant and biometals chelator...
April 23, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28439701/the-influence-of-different-sets-of-surgical-instrumentation-in-oxford-uka-on-bearing-size-and-component-position
#9
Tilman Walker, Pascal Heinemann, Thomas Bruckner, Marcus R Streit, Stefan Kinkel, Tobias Gotterbarm
INTRODUCTION: The Oxford unicompartmental knee arthroplasty (OUKA) has been proven to be an effective treatment for anteromedial osteoarthritis of the knee joint. New instrumentation has been introduced to improve the reproducibility of implant positioning and to minimize bone loss during tibial resection (Oxford Microplasty; Zimmer Biomet, Warsaw, Indiana, USA). METHODS: To assess the effect of the new instrumentation, we retrospectively evaluated the postoperative radiographs and surgical records of 300 OUKAs in three consecutive cohorts of patients...
April 24, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28437496/novel-solution-for-massive-glenoid-defects-in-shoulder-arthroplasty-a-patient-specific-glenoid-vault-reconstruction-system
#10
David M Dines, Lawrence Gulotta, Edward V Craig, Joshua S Dines
Complex glenoid deformities present the most difficult challenges in shoulder arthroplasty. These deformities may be caused by severe degenerative or congenital deformity, posttraumatic anatomy, tumor, or, in most cases, bone loss after glenoid failure in anatomical total shoulder arthroplasty. Methods of treating severe bone loss have included inlay and onlay bone-graft options with augmented fixation and, in severe cases, salvage hemiarthroplasty with limited goal expectations. Unfortunately, none of these methods has provided consistently satisfactory reproducible results...
March 2017: American Journal of Orthopedics
https://www.readbyqxmd.com/read/28434071/repeatability-and-agreement-of-central-corneal-thickness-measurement-with-non-contact-methods-a-comparative-study
#11
Tarannum Mansoori, Nagalla Balakrishna
PURPOSE: To compare the central corneal thickness (CCT) measurements and reliability of RTVue XR-100 anterior segment optical coherence tomography (AS-OCT), AL-scan optical biometer and Schwind Sirius anterior segment analysis system. METHODS: The CCT was measured in one hundred and twenty-seven eyes of 127 healthy subjects with AS-OCT, AL-scan and Sirius system. Mean CCT was compared among the instruments, and the level of agreement was assessed using Bland-Altman plots...
April 22, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28410713/axial-length-measurements-comparison-of-a-new-swept-source-optical-coherence-tomography-based-biometer-and-partial-coherence-interferometry-in-myopia
#12
Jong Yun Yang, Hong Kyu Kim, Sung Soo Kim
PURPOSE: To compare axial length (AL) measurements between a swept-source optical coherence tomography (SS-OCT) biometer (IOLMaster 700) and a partial coherence interferometry (PCI) biometer (IOLMaster, version 5.4) in myopic eyes. SETTING: Severance Hospital, Yonsei University, Seoul, South Korea. DESIGN: Prospective evaluation of a diagnostic test. METHODS: This study enrolled patients with a diagnosis of myopia in their medical records...
March 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28405580/temporomandibular-joint-reconstruction-with-alloplastic-prosthesis-the-outcomes-of-four-cases
#13
Jung-Hyun Park, Eun Jo, Hoon Cho, Hyung Jun Kim
BACKGROUND: The purpose of this study is to evaluate the outcomes of four patients receiving stock Biomet TMJ prosthesis for reconstruction of the TMJs. METHODS: TMJ reconstruction with stock Biomet TMJ prosthesis was performed in four patients who had joint damages by trauma, tumor, resorption, and ankylosis, which represent the indications of alloplastic prosthesis. RESULTS: Loss of condyle from trauma and resorption of joint are good indications for prosthesis, but the patients should be informed about limitation of jaw movement...
December 2017: Maxillofacial Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28405187/identification-of-cerebral-metal-ion-imbalance-in-the-brain-of-aging-octodon-degus
#14
Nady Braidy, Anne Poljak, Chris Marjo, Helen Rutlidge, Anne Rich, Bat-Erdene Jugder, Tharusha Jayasena, Nibaldo C Inestrosa, Perminder S Sachdev
The accumulation of redox-active transition metals in the brain and metal dyshomeostasis are thought to be associated with the etiology and pathogenesis of several neurodegenerative diseases, and Alzheimer's disease (AD) in particular. As well, distinct biometal imaging and role of metal uptake transporters are central to understanding AD pathogenesis and aging but remain elusive, due inappropriate detection methods. We therefore hypothesized that Octodon degus develop neuropathological abnormalities in the distribution of redox active biometals, and this effect may be due to alterations in the expression of lysosomal protein, major Fe/Cu transporters, and selected Zn transporters (ZnTs and ZIPs)...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28402713/optical-biometry-derived-axial-length-measurements-following-intravitreal-anti-vascular-endothelial-growth-factor-treatment-for-macular-edema
#15
George D Kymionis, Athanassios Giarmoukakis, Ioanna K Apostolidi, Styliani V Blazaki, Konstantinos I Tsoulnaras, Joanna Moschandrea, Sofia Panagopoulou, Miltiadis K Tsilimbaris
PURPOSE: To evaluate axial length (AL) alterations in patients with macular disease over the course of intravitreal anti-vascular endothelial growth factor (anti-VEGF) treatment. METHODS: In this prospective, comparative study, 33 patients with macular edema underwent unilaterally intravitreal anti-VEGF therapy and were followed for two months; the contralateral eyes were considered as controls. Central retinal thickness (CRT) was measured with spectral-domain optical coherence tomography and AL with an IOL-Master optical biometer...
April 12, 2017: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/28401081/zinc-in-pancreatic-islet-biology-insulin-sensitivity-and-diabetes
#16
REVIEW
Wolfgang Maret
About 20 chemical elements are nutritionally essential for humans with defined molecular functions. Several essential and nonessential biometals are either functional nutrients with antidiabetic actions or can be diabetogenic. A key question remains whether changes in the metabolism of biometals and biominerals are a consequence of diabetes or are involved in its etiology. Exploration of the roles of zinc (Zn) in this regard is most revealing because 80 years of scientific discoveries link zinc and diabetes...
March 2017: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/28390770/rationale-and-design-of-the-marrowstim-pad-kit-for-the-treatment-of-critical-limb-ischemia-in-subjects-with-severe-peripheral-arterial-disease-mobile-trial-investigating-autologous-bone-marrow-cell-therapy-for-critical-limb%C3%A2-ischemia
#17
S Keisin Wang, Linden A Green, Raghu L Motaganahalli, Michael G Wilson, Andres Fajardo, Michael P Murphy
OBJECTIVE: Critical limb ischemia (CLI) continues to place a significant encumbrance on patients and the health care system as it progresses to limb loss and long-term disability. Traditional methods of revascularization offer a significant benefit; however, for one-third of CLI patients, these surgical options are not technically possible or patency is severely limited by disease burden (deemed "poor-option" for revascularization). In a previous phase I trial, we demonstrated intramuscular injection of concentrated bone marrow aspirate (cBMA) via MarrowStim (Zimmer Biomet, Warsaw, Ind) harvest is safe and may decrease major amputation in patients with CLI unfit for surgical revascularization...
June 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28385933/risk-factors-for-post-operative-periprosthetic-fractures-following-primary-total-hip-arthroplasty-with-a-proximally-coated-double-tapered-cementless-femoral-component
#18
K Gromov, A Bersang, C S Nielsen, T Kallemose, H Husted, A Troelsen
AIMS: The aim of this study was to identify patient- and surgery-related risk factors for sustaining an early periprosthetic fracture following primary total hip arthroplasty (THA) performed using a double-tapered cementless femoral component (Bi-Metric femoral stem; Biomet Inc., Warsaw, Indiana). PATIENTS AND METHODS: A total of 1598 consecutive hips, in 1441 patients receiving primary THA between January 2010 and June 2015, were retrospectively identified. Level of pre-operative osteoarthritis, femoral Dorr type and cortical index were recorded...
April 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28378582/low-affinity-zinc-sensor-showing-fluorescence-responses-with-minimal-artifacts
#19
Xinhao Yan, Jin Ju Kim, Hye Sun Jeong, Yu Kyung Moon, Yoon Kyung Cho, Soyeon Ahn, Sang Beom Jun, Hakwon Kim, Youngmin You
The study of the zinc biology requires molecular probes with proper zinc affinity. We developed a low-affinity zinc probe (HBO-ACR) based on an azacrown ether (ACR) and an 2-(2-hydroxyphenyl)benzoxazole (HBO) fluorophore. This probe design imposed positive charge in the vicinity of a zinc coordination center, which enabled fluorescence turn-on responses to high levels of zinc without being affected by the pH and the presence of other transition-metal ions. Steady-state and transient photophysical investigations suggested that such a high tolerance benefits from orchestrated actions of proton-induced nonradiative and zinc-induced radiative control...
April 5, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28375152/metallomics-a-primer-of-integrated-biometal-sciences-by-wolfgang-maret-imperial-college-press-2016-pp-xiii-141-price-gbp-30-00-paperback-isbn-978-1-78326-828-3-gbp-56-00-hardback-isbn-978-1-78326-827-6
#20
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