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https://www.readbyqxmd.com/read/27924742/dual-mobility-total-hip-replacement-in-a-high-risk-population
#1
Jatinder Singh Luthra, Amur Al Riyami, Mohamad Kasim Allami
OBJECTIVE: The purpose of the study was to evaluate results of dual mobility total replacement in a high risk population who take hip into hyperflexed position while sitting and praying on the floor. METHOD: The study included 65 (35 primary total replacement and 30 complex total hip replacement) cases of total hip replacement using avantage privilege dual mobility cup system from biomet. A cemented acetabular component and on femoral side a bimetric stem, either cemented or uncemented used depending on the canal type...
2016: SICOT-J
https://www.readbyqxmd.com/read/27923535/multitarget-drug-design-strategy-against-alzheimer-s-disease-homoisoflavonoid-mannich-base-derivatives-serve-as-acetylcholinesterase-and-monoamine-oxidase-b-dual-inhibitors-with-multifunctional-properties
#2
Yan Li, Xiaoming Qiang, Li Luo, Xia Yang, Ganyuan Xiao, Yunxiaozhu Zheng, Zhongcheng Cao, Zhipei Sang, Fu Su, Yong Deng
A series of homoisoflavonoid Mannich base derivatives were designed, synthesized and evaluated as multifunctional agents against Alzheimer's disease. It demonstrated that most of the derivatives were selective AChE and MAO-B dual inhibitors with good multifunctional properties. Among them, compound 10d displayed the comprehensive advantages, with excellent AChE and MAO-B inhibitory activities (IC50=2.49±0.08nM and 1.74±0.0581μM, respectively), good self- and Cu(2+)-induced Aβ1-42 aggregation inhibitory potency, antioxidant activity, biometal chelating ability and high BBB permeability...
November 28, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/27900479/evaluation-of-the-repeatability-of-a-swept-source-ocular-biometer-for-measuring-ocular-biometric-parameters
#3
Teresa Ferrer-Blasco, Alberto Domínguez-Vicent, José J Esteve-Taboada, Miguel A Aloy, Jose E Adsuara, Robert Montés-Micó
PURPOSE: The purpose was to evaluate the repeatability of a new swept-source optical biometer for measuring ocular biometric parameters. METHODS: Thirty subjects with healthy and phakic eyes were included in this study, and only one eye per participant was analysed. Each eye was measured five times with the IOLMaster 700 swept-source optical biometer (Carl Zeiss Meditec, Jena, Germany). Axial length (AL), anterior chamber depth (ACD), central corneal thickness (CCT), lens thickness (LT), white-to-white (WTW), and K1 and K2 keratometric readings were evaluated...
November 30, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/27894148/catastrophic-failure-of-regenerex-tibial-components-a-case-series
#4
Gavin Stormont, Daniel Stormont
The aim of this study was to analyze short-term metal failures in well-placed Signature-guided Regenerex (Zimmer Biomet, Warsaw, IN) tibial components in a limited patient series. A retrospective, consecutive, nonrandomized, unblinded study from a limited cohort of young active osteoarthritis patients was conducted. All cases received a Regenerex tibial component which we evaluated for metal failure. Patients met the then current indications from the Center for Medicare and Medicaid Services Guidelines for knee replacement...
November 28, 2016: Journal of Knee Surgery
https://www.readbyqxmd.com/read/27876531/patient-centered-quality-of-life-measures-after-alloplastic-temporomandibular-joint-replacement-surgery
#5
X Alakailly, D Schwartz, N Alwanni, C Demko, M A Altay, Y Kilinc, D A Baur, F Quereshy
The purpose of this study was to evaluate patient-reported outcome measures of quality of life (QoL) for patients with end-stage temporomandibular joint (TMJ) disease who have undergone TMJ prosthetic replacement. The records of 36 patients who had undergone alloplastic total joint replacement procedures were analyzed. Patients were treated using either TMJ Concepts or Biomet/Lorenz prosthetics. Patients were asked to complete a 12-item TMJ-S-QoL survey, which encompassed questions pertaining to pain, speech, chewing function, and various aspects of social life and mental health...
November 19, 2016: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27843285/clinical-outcomes-with-toric-intraocular-lenses-planned-using-an-optical-low-coherence-reflectometry-ocular-biometer-with-a-new-toric-calculator
#6
Kjell G Gundersen, Richard Potvin
PURPOSE: To prospectively evaluate postoperative clinical outcomes with implantation of toric intraocular lenses (IOLs) using preoperative keratometry from an optical low coherence reflectometry (OLCR) ocular biometer (Lenstar(®) LS900) and the built-in Barrett toric calculator. PATIENTS AND METHODS: A prospective observational study recruited one or both eyes of subjects who underwent uncomplicated cataract surgery with toric IOL implantation using OLCR biometery data and the Barrett toric IOL calculator for toric IOL planning...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27834962/agreement-and-clinical-comparison-between-a-new-swept-source-optical-coherence-tomography-based-optical-biometer-and-an-optical-low-coherence-reflectometry-biometer
#7
P Arriola-Villalobos, J Almendral-Gómez, N Garzón, J Ruiz-Medrano, C Fernández-Pérez, J M Martínez-de-la-Casa, D Díaz-Valle
PurposeTo compare measurements taken using a swept-source optical coherence tomography-based optical biometer (IOLmaster 700) and an optical low-coherence reflectometry biometer (Lenstar 900), and to determine the clinical impacts of differences in their measurements on intraocular lens (IOL) power predictions.MethodsEighty eyes of 80 patients scheduled to undergo cataract surgery were examined with both biometers. The measurements made using each device were axial length (AL), central corneal thickness (CCT), aqueous depth (AQD), lens thickness (LT), mean keratometry (MK), white-to-white distance (WTW), and pupil diameter (PD)...
November 11, 2016: Eye
https://www.readbyqxmd.com/read/27833928/comparison-of-a-new-optical-biometer-and-a-standard-biometer-in-cataract-patients
#8
Pipat Kongsap
BACKGROUND: Cataract surgery is the most common surgical procedure in ophthalmology. Biometry data and accurate intraocular lens (IOL) calculations are very important in achieving the desired refractive outcomes. The aim of this study was to compare measurements using a new optical low coherence reflectometry (OLCR) biometer (OA-2000) and the gold standard partial coherence interferometry (PCI) optical biometer (IOLMaster 500). METHODS: Ocular biometry of cataract patients were measured by the OA-2000 and IOLMaster 500 to compare keratometry (K), axial length (AL), anterior chamber depth (ACD), white-to-white (WTW) diameter, and IOL power using the SRK/T formula...
2016: Eye and Vision (London, England)
https://www.readbyqxmd.com/read/27800269/early-postoperative-effects-of-cataract-surgery-on-anterior-segment-parameters-in-primary-open-angle-glaucoma-and-pseudoexfoliation-glaucoma
#9
Ufuk Elgin, Emine Şen, Tülay Şimşek, Kemal Tekin, Pelin Yılmazbaş
OBJECTIVES: To compare the effect of cataract surgery on anterior segment parameters measured by optical biometry in primary open-angle glaucoma (POAG) and pseudoexfoliation glaucoma (PXG). MATERIALS AND METHODS: Twenty-five eyes of 25 patients with POAG and 29 eyes of 29 patients with PXG who had uncomplicated phacoemulsification and posterior chamber intraocular lens implantation surgery were included to our prospective study. Central corneal thickness (CCT), anterior chamber depth (ACD) and axial length (AL) were measured with an optical biometer preoperatively and at 1 month postoperatively...
June 2016: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/27798203/analysis-of-linezolid-and-tigecycline-as-candidates-for-local-prophylaxis-via-antibiotic-loaded-bone-cement
#10
T Nichol, T J Smith, R Townsend, I Stockley, R Akid
OBJECTIVES: To assess the Gram-positive-specific antibiotic linezolid and the broad-spectrum antibiotic tigecycline for use in local antibiotic delivery via antibiotic-loaded bone cement. METHODS: Linezolid and tigecycline were added to Biomet bone cement at varying concentrations. Antibiotic elution over 1 week was quantified by HPLC-MS. The effect of wear on elution over 51 h was determined using a modified TE-66 wear tester. Eluted antibiotics were used to determine the MICs for a panel of clinically relevant bacteria...
October 21, 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27793471/effect-of-pharmacological-pupil-dilation-on-measurements-and-iol-power-calculation-made-using-the-new-swept-source-optical-coherence-tomography-based-optical-biometer
#11
P Arriola-Villalobos, J Almendral-Gómez, N Garzón, J Ruiz-Medrano, C Fernández-Pérez, J M Martínez-de-la-Casa, D Díaz-Valle
PURPOSE: To determine whether pupil dilation affects biometric measurements and intraocular lens (IOL) power calculation made using the new swept-source optical coherence tomography-based optical biometer (IOLMaster 700(©); Carl Zeiss Meditec, Jena, Germany). PROCEDURES: Eighty-one eyes of 81 patients evaluated for cataract surgery were prospectively examined using the IOLMaster 700(©) before and after pupil dilation with tropicamide 1%. The measurements made were: axial length (AL), central corneal thickness (CCT), aqueous chamber depth (ACD), lens thickness (LT), mean keratometry (MK), white-to-white distance (WTW) and pupil diameter (PD)...
October 25, 2016: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/27780349/early-experience-with-vitamin-e-antioxidant-infused-highly-cross-linked-polyethylene-inserts-in-primary-total-knee-arthroplasty
#12
Emilie M Flament, Keith R Berend, Jason M Hurst, Michael J Morris, Joanne B Adams, Adolph V Lombardi
BACKGROUND: In past decades, polyethylene wear was a major cause of failure in total knee arthroplasty (TKA). Polyethylene for use in arthroplasty has been vastly improved in recent years, with improved materials as well as manufacturing and sterilization processes. Testing has shown that infusion of vitamin E prevents oxidative degradation of polyethylene without remelting, allowing the material to maintain mechanical properties and wear resistance over time. The purpose of this study is to review the early result of patients undergoing primary TKA with vitamin E antioxidant-infused polyethylene inserts...
October 26, 2016: Surgical Technology International
https://www.readbyqxmd.com/read/27759829/analysis-of-cytokine-profile-and-growth-factors-in-platelet-rich-plasma-obtained-by-open-systems-and-commercial-columns
#13
Alberto de Castro Pochini, Eliane Antonioli, Daniella Zanetti Bucci, Luiz Roberto Sardinha, Carlos Vicente Andreoli, Mario Ferretti, Benno Ejnisman, Anna Carla Goldberg, Moisés Cohen
Objective: To evaluate growth factors and cytokines in samples of platelet-rich plasma obtained by three different centrifugation methods. Methods: Peripheral blood of six individuals with no hematological diseases, aged 18 to 68 years, was drawn to obtain platelet-rich plasma, using the open method and commercial columns by Medtronic and Biomet. The products obtained with the different types of centrifugation were submitted to laboratory analysis, including pro-inflammatory cytokines and chemokines by flow cytometry assays, the concentration of fibroblast growth factors-2 (FGF-2) and transforming growth factor-beta1 (TGF-β1)...
July 2016: Einstein
https://www.readbyqxmd.com/read/27741085/predictability-of-biometry-in-patients-undergoing-cataract-surgery
#14
Nir Sorkin, Amir Rosenblatt, Irina S Barequet
PURPOSE: To compare measurements of axial length (AL), anterior chamber depth (ACD), keratometry (K), and the refractive predictability of the Aladdin and IOLMaster biometry devices in cataract surgery patients. METHODS: A retrospective observational study of eyes undergoing cataract surgery. Data were retrieved on AL, ACD, and K measurements obtained by the Aladdin and the IOLMaster. Furthermore, the postoperative refractive prediction errors were compared between the devices...
December 2016: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/27722757/comparison-of-al-scan-and-iolmaster-500-partial-coherence-interferometry-optical-biometers
#15
Kenneth J Hoffer, Giacomo Savini
PURPOSE: To investigate agreement between the ocular biometry measurements provided by a newer optical biometer, the AL-Scan (Nidek Co, Ltd., Gamagori, Japan) and those provided by the IOLMaster 500 (Carl Zeiss Meditec, Jena Germany), which are both based on partial coherence interferometry. METHODS: Axial length, corneal power, and anterior chamber depth (corneal epithelium to lens) were measured in 86 eyes of 86 patients scheduled for cataract surgery using both biometers...
October 1, 2016: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/27722221/a-10-year-report-from-a-multicentre-randomised-controlled-trial-immediate-non-occlusal-versus-early-loading-of-dental-implants-in-partially-edentulous-patients
#16
Francesco Zuffetti, Marco Esposito, Fabio Galli, Matteo Capelli, Giovanni Grandi, Tiziano Testori
PURPOSE: To compare peri-implant bone and soft-tissue levels of immediate non-occlusally loaded versus non-submerged early loaded implants in partially edentulous patients 10 years after loading. MATERIALS AND METHODS: Fifty-two patients were randomised in five Italian private practices: 25 in the immediately loaded group and 27 in the early loaded group. To be immediately loaded, single implants had to be inserted with a torque of at least 30 Ncm, and splinted implants with a torque of at least 20 Ncm...
2016: European Journal of Oral Implantology
https://www.readbyqxmd.com/read/27711119/clinical-and-wear-analyses-of-9-large-metal-on-metal-total-hip-prostheses
#17
M C Koper, N M C Mathijssen, F Witt, M M Morlock, S B W Vehmeijer
BACKGROUND: Metal-on-Metal (MoM) total hip arthroplasties (THA) are associated with pseudotumor formation and high revision rates. This prospective study analysed the clinical and wear analyses of 9 large Metal-on-Metal (MoM) total hip arthroplasties (THA) to understand the underlying mechanisms of failure. The MoM bearings were revised for multiple reasons; the main reason was pseudotumor formation. MATERIALS AND METHODS: From 2006 till 2010 the Reinier de Graaf Hospital implanted 160 large head M2a-Magnum™ (Biomet Inc...
2016: PloS One
https://www.readbyqxmd.com/read/27697055/multitarget-tacrine-hybrids-with-neuroprotective-properties-to-confront-alzheimer-s-disease
#18
Katarina Spilovska, Jan Korabecny, Eugenie Nepovimova, Rafael Dolezal, Eva Mezeiova, Ondrej Soukup, Kamil Kuca
Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder. Several hallmarks such as β-amyloid (Aβ) aggregation underlying amyloid plaque formation, τ-hyperphosphorylation leading to the production of neurofibrillary tangles, and decline in the number of cholinergic neurons appear to be fundamental in the pathophysiology of the disease. Other evidence points also to the involvement of oxidative stress, biometal dyshomeostasis, inflammation, and cell cycle regulatory failure. Taking into account such premises, many attractive targets for the development of anti-AD drugs have emerged...
September 27, 2016: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/27664702/axial-length-measurement-failure-rates-with-biometers-using-swept-source-optical-coherence-tomography-compared-to-partial-coherence-interferometry-and-optical-low-coherence-interferometry
#19
Colm McAlinden, Qinmei Wang, Rongrong Gao, Weiqi Zhao, Ayong Yu, Yu Li, Yan Guo, Jinhai Huang
PURPOSE: To compare a new swept-source optical coherence tomography (SSOCT)-based biometer (OA-2000) with the IOLMaster v5.4 (partial-coherence interferometry) and Aladdin (optical low-coherence interferometry) biometers in terms of axial length measurement and failure rate in eyes with cataract. DESIGN: Reliability study. METHODS: A total of 377 eyes of 210 patients were scanned with the 3 biometers in a random order. For each biometer, the number of unobtainable axial length measurements was recorded and grouped as per the type and severity of cataract based on the Lens Opacities Classification System III by the same experienced ophthalmologist...
January 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27644588/total-temporomandibular-joint-replacement-prostheses-a-systematic-review-and-bias-adjusted-meta-analysis
#20
N R Johnson, M J Roberts, S A Doi, M D Batstone
The aim of the present study was to determine which prosthesis has resulted in the best outcomes after total temporomandibular joint replacement (TMJR). A comprehensive electronic search was undertaken in September 2015. Inclusion criteria encompassed studies that described one of the three current TMJR systems and that had pre- and postoperative data on at least two of the following TMJR indications: pain, diet, function, and maximum inter-incisal opening (MIO). Sixteen papers were included in the systematic review, reporting 10 retrospective studies and six prospective studies (no randomized controlled or case-controlled trials)...
September 16, 2016: International Journal of Oral and Maxillofacial Surgery
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