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Adolph V Lombardi, Antonio G Manocchio, Keith R Berend, Michael J Morris, Joanne B Adams
INTRODUCTION: Short stem femoral components in primary total hip arthroplasty (THA) have increased in popularity since the advent of minimally invasive surgical techniques. The concept of a short stem is particularly compatible with tapered designs where the goal is to offload forces proximally in the femur. The purpose of this retrospective review was to review our early experience with a short, tapered titanium femoral component with updated design features. MATERIALS AND METHODS: Beginning in November 2011 through February 2012, 92 consented patients (93 hips), at a single center, were treated with primary cementless THA using a short stem, tapered femoral component (Taperloc® Complete Microplasty; Zimmer Biomet, Warsaw, Indiana) and were available for review with a minimum two-year follow-up...
March 12, 2018: Surgical Technology International
Y L Rodrigues, M T Mathew, L G Mercuri, J S P da Silva, B Henriques, J C M Souza
The aim of this study was to perform a literature review on the use of finite element modeling (FEM) for the evaluation of the biomechanical behavior of temporomandibular joint replacement (TMJR) devices. An electronic search of online medical and scientific literature database was conducted using selected search terms. The search identified 307 studies, of which 19 were considered relevant to this study. Of the 19 selected studies, 10 (52.6%) investigated the influence of geometry and fixation methods, while two (10...
March 8, 2018: International Journal of Oral and Maxillofacial Surgery
Cosimo Walter D'Acunto, Robert Kaplánek, Helena Gbelcová, Zdeněk Kejík, Tomáš Bříza, Liudmila Vasina, Martin Havlík, Tomáš Ruml, Vladimír Král
Alzheimer's disease (AD) is a progressive neurodegenerative disorder affecting tens of million people. Currently marketed drugs have limited therapeutic efficacy and only slowing down the neurodegenerative process. Interestingly, it has been suggested that biometal cations in the amyloid beta (Aβ) aggregate deposits contribute to neurotoxicity and degenerative changes in AD. Thus, chelation therapy could represent novel mode of therapeutic intervention. Here we describe the features of chelators with therapeutically relevant mechanism of action...
March 2, 2018: European Journal of Medicinal Chemistry
Miri Na, Aeri Yoo
PURPOSE: To evaluate the effectiveness of the orthokeratology (OK) lens slowing myopic progression compared with no intervention in pediatric eyes METHODS: A retrospective review of medical records was performed on 45 monocular myopic subjects 7 to 13 years of age who were treated with monocular ortho-k lens and followed-up for more than 12 months. The monocular myopia in the subjects' eyes was -0.75 to -4.25 D (diopter), and near emmetropia in the contralateral and with-the-rule astigmatism no greater than -1...
March 9, 2018: Japanese Journal of Ophthalmology
Mitchell P McInerney, Irene Volitakis, Ashley I Bush, William A Banks, Jennifer L Short, Joseph A Nicolazzo
PURPOSE: Biometals such as zinc and copper have been shown to affect tight junction expression and subsequently blood-brain barrier (BBB) integrity. Whether these biometals also influence the expression and function of BBB transporters such as P-glycoprotein (P-gp) however is currently unknown. METHODS: Using the immortalised human cerebral microvascular endothelial (hCMEC/D3) cell line, an in-cell western assay (alongside western blotting) assessed relative P-gp expression after treatment with the metal ionophore clioquinol and biometals zinc and copper...
March 5, 2018: Pharmaceutical Research
Zaixing Huang, Fangjing Liu, Michael A Urynowicz, Franco Basile, Hongguang Guo, Liwei Chen, Paul H Fallgren, Song Jin
Coalbed methane (CBM) is an important unconventional energy source and accounts for a substantial portion of the overall natural gas production in the USA. The extraction of CBM generates significant amounts of produced water, where the withdrawal of groundwater may disturb the subsurface environment and aquifers. The release of toxic recalcitrant compounds from the coal seam is of great concern for those who use groundwater for irrigation and potable water sources. Experiments were conducted that determined a small fraction of coal carbon can be extracted and solubilized in water during the CBM formation and production...
March 1, 2018: Environmental Geochemistry and Health
Vojtěch Kubíček, Zuzana Böhmová, Romana Ševčíková, Jakub Vaněk, Přemysl Lubal, Zuzana Poláková, Romana Michalicová, Jan Kotek, Petr Hermann
H3 nota derivatives are among the most studied macrocyclic ligands and are widely used for metal ion binding in biology and medicine. Despite more than 40 years of chemical research on H3 nota, the comprehensive study of its solution chemistry has been overlooked. Thus, the coordination behavior of H3 nota with several divalent metal ions was studied in detail with respect to its application as a chelator for copper radioisotopes in medical imaging and therapy. In the solid-state structure of the free ligand in zwitterionic form, one proton is bound in the macrocyclic cavity through a strong intramolecular hydrogen-bond system supporting the high basicity of the ring amine groups (log Ka = 13...
February 28, 2018: Inorganic Chemistry
Yanjun Hua, Wei Qiu, Qiuyi Xiao, Qiang Wu
PURPOSE: To assess the precision (repeatability and reproducibility) of ocular parameters measured by the Tomey OA-2000 biometer, and to compare them with those measured by the IOLMaster. METHODS: In this prospective study, the right eyes of 108 healthy subjects were included. Three consecutive scans were obtained by 2 observers using the Tomey OA-2000, and in the same session one observer used the IOLMaster (version for the measurements. About 1 week later, 3 scans were obtained by one observer using the Tomey OA-2000...
2018: PloS One
Liu He, Ashley Boice, Kai Liu, Xing Yan, Yuqi Jiang, Shijun Zhang
In our continuing efforts to develop bivalent compounds as potential neuroprotectants for Alzheimer's disease, a series of bivalent compounds that contain cholesterylamine and an extended spacer were synthesized and biologically characterized. Our results demonstrated that incorporation of a piperazine ring into the spacer composition significantly improved the protective potency in MC65 cell models. Our results also suggested that the optimal spacer length for such bivalent compounds ranges from 17 to 21 atoms, and further spacer extension beyond 21 atoms results no further optimization...
February 14, 2018: Bioorganic & Medicinal Chemistry Letters
D J du Preez, J L du Plessis, C Y Wright
BACKGROUND: Observing accurate real-time measurements of solar ultraviolet radiation (UVR) levels is important since personal excess sun exposure is associated with skin cancers. Handheld measurement devices may be helpful but their accuracy is unknown. We compare a portable, science-grade solar UVR monitoring device against two fixed, science-grade solar UVR instruments. METHODS: Instruments were (1) a fixed Solar Light 501 UV-B biometer to measure UV-B; (2) a fixed Kipp and Zonen radiometer used to measure UV-A and UV-B; and (3) Goldilux ultraviolet probes which are commercially available portable devices...
February 23, 2018: Skin Research and Technology
M Zimlitski, L Natchkebia, G Loria, G Zimlitski, V Gvazava, A Gardeev
In this paper, we have studied the difference between classic Watson Jones anterolateral approach and modified anterolateral approach started in our institution from 2004 y. in group of patients with BMI more then 30 - 412 patients, mean age was 66,5 y., male -157 (38.2%), female - 255 (61,8%). Primary diagnosis were: Idiopathic osteoarthritis - 379 (92%), Rheumatoid ostheoarthritis - 16 (4%), DDH - 12 (3%). All surgeries were performed on supine position. All surgeries were performed by single surgeon. In 321 (78%) of cases modified approach was used...
January 2018: Georgian Medical News
Zhiren Wang, Jinhui Hu, Xiaoping Yang, Xing Feng, Xingshu Li, Ling Huang, Albert S C Chan
A novel series of quinoline-indole derivatives were synthesized and evaluated as multitarget-directed ligands for the treatment of Alzheimer's disease (AD). Biological evaluation revealed that the derivatives had multifunctional profiles including antioxidant effects, blood-brain barrier (BBB) penetration, biometal chelation, Aβ aggregation modulation, neurotrophic and neuroprotective properties. Moreover, several representative target derivatives demonstrated hippocampal cell proliferation in living adult mice by intracerebroventricular (icv) injection or oral administration...
February 15, 2018: Journal of Medicinal Chemistry
Zhongcheng Cao, Jie Yang, Rui Xu, Qin Song, Xiaoyu Zhang, Hongyan Liu, Xiaoming Qiang, Yan Li, Zhenghuai Tan, Yong Deng
A series of 4'-OH-flurbiprofen-chalcone hybrids were designed, synthesized and evaluated as potential multifunctional agents for the treatment of Alzheimer's disease. The biological screening results indicated that most of these hybrids exhibited good multifunctional activities. Among them, compounds 7k and 7m demonstrated the best inhibitory effects on self-induced Aβ1-42 aggregation (60.0% and 78.2%, respectively) and Cu2+-induced Aβ1-42 aggregation (52.4% and 95.0%, respectively). Moreover, these two representative compounds also exhibited good antioxidant activities, MAO inhibitions, biometal chelating abilities and anti-neuroinflammatory activities in vitro...
February 2, 2018: Bioorganic & Medicinal Chemistry
S Aubret, L Merlini, M Fessy, J L Besse
INTRODUCTION: One of the reasons for revision of total ankle replacement (TAR) implants is loosening due to subchondral cysts. Reconstruction and fusion of the ankle is often the first choice for revision procedures due to the large bone defects, which are typically filled with autograft and/or allograft. Filling the defect with a trabecular metal tantalum implant is a potential alternative given the biomechanical properties of this component. HYPOTHESIS: Using tantalum as a spacer provides primary stability and contributes to fusion of the ankle joint after removal of failed TAR implants...
January 30, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
L de-Pablo-Gómez-de-Liaño, J I Fernández-Vigo, N Ventura-Abreu, B Benito-Pascual, C Narváez-Palazón, R Gómez-de-Liaño
OBJECTIVE: To report reference values for the horizontal rectus muscles thickness using Spectral Domain optical coherence tomography (SD-OCT), and to evaluate whether there are any correlations between the muscle thickness and gender, age, or axial length (AL). MATERIAL AND METHODS: A cross-sectional study was conducted on 131 right eyes of healthy subjects. The gender and age were recorded, and axial length was measured using an optical biometer. The medial rectus (MR) muscle thickness was measured at 7...
February 1, 2018: Archivos de la Sociedad Española de Oftalmología
Jorge A Calvo-Sanz, Alejandro Portero-Benito, Alfonso Arias-Puente
PURPOSE: To compare and evaluate the agreement between the measurements obtained with a swept-source optical coherence tomography (OCT)-based biometer, the IOLMaster® 700 (IOLM), and those obtained by an optical biometer based on optical low-coherence interferometry (OLCI), the Aladdin (ALD); To evaluate the ability to perform biometric measurements in those eyes with transparency alterations. METHODS: Fifty-five eyes of 55 subjects were included in this study...
February 1, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Sabiha Farooq, Wardah Mazhar, Amna Jabbar Siddiqui, Saqib Hussain Ansari, Syed Ghulam Musharraf
β-Thalassemia is one of the most common inherited disorder that is widely distributed throughout the world. Due to severe deficiencies in red blood cells (RBCs) production, blood transfusion is required to correct anemia for normal growth and development but causes additional complications due to iron overload. The aim of this study is to quantify the biometal dysregulations in β-thalassemia patients as compared to healthy controls. A total of 17 elements were analyzed in serum samples of β-thalassemia patients and healthy controls using ICP-MS followed by chemometric analyses...
January 31, 2018: Biomedical Chromatography: BMC
C Smeekes, B J M Schouten, M Nix, B F Ongkiehong, R Wolterbeek, B C H van der Wal, R G H H Nelissen
OBJECTIVE: Pseudotumors, a well-known complication of metal-on-metal total hip arthroplasty (MoM THA), are well identified on metal artifact-reducing sequences magnetic resonance imaging (MARS-MRI). Several MRI grading systems are described in the orthopedic literature, but their validity is unknown in large clinical studies. Our study was undertaken to describe the classification of pseudotumors in a preselected cohort divided into high- and low-risk patients, using three pseudotumor grading systems applied on MARS-MRI, and to determine the interobserver reliability of the grading systems...
February 1, 2018: Skeletal Radiology
Mathilde Sarlabous, David J Psutka
AIM: To describe the treatment of ameloblastoma involving the mandibular body and condyle in 3 patients. METHODS: This report describes 3 patients with large ameloblastomas (2 were second recurrences) treated by partial mandibular resection. Involvement of the mandibular condyle in these 3 patients made the reconstruction more challenging. Reconstruction included immediate temporomandibular joint replacement by a custom-made alloplastic total joint and mandibular body (Zimmer-Biomet, Jacksonville, FL)...
February 7, 2018: Journal of Craniofacial Surgery
Sylwia Wośko, Anna Serefko, Aleksandra Szopa, Piotr Wlaź, Andrzej Wróbel, Aleksandra Wlaź, Jolanta Górska, Ewa Poleszak
OBJECTIVE: During the last few decades, endocannabinoid system has emerged as a novel possible target for antidepressant treatment. Although the medical literature provides information on the mood-changing effects of CB1 ligands, little is known about the possible interaction between the simultaneous activation or inhibition of the CB1 receptor and administration of other agents that possess antidepressant potential. The main goal of our study was to evaluate the influence of the CB1 cannabinoid receptor ligands (oleamide - an endogenous agonist and AM251 - an inverse agonist/antagonist) on the antidepressant-like activity of biometals (i...
January 30, 2018: Journal of Pharmacy and Pharmacology
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