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https://www.readbyqxmd.com/read/28811866/preliminary-data-on-the-interaction-between-some-biometals-and-oxidative-stress-status-in-mild-cognitive-impairment-and-alzheimer-s-disease-patients
#1
Ioana-Miruna Balmuș, Stefan-Adrian Strungaru, Alin Ciobica, Mircea-Nicusor Nicoara, Romeo Dobrin, Gabriel Plavan, Cristinel Ștefănescu
Increased interest regarding the biometal mechanisms of action and the pathways in which they have regulatory roles was lately observed. Particularly, it was shown that biometal homeostasis dysregulation may lead to neurodegeneration including Alzheimer's disease, Parkinson disease, or prion protein disease, since important molecular signaling mechanisms in brain functions implicate both oxidative stress and redox active biometals. Oxidative stress could be a result of a breakdown in metal-ion homeostasis which leads to abnormal metal protein chelation...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28809380/production-of-bone-mineral-material-and-bmp-2-in-osteoblasts-cultured-on-double-acid-etched-titanium
#2
R Velázquez-Cayón, G Castillo-Dalí, J-R Corcuera-Flores, M-A Serrera-Figallo, R Castillo-Oyagüe, M González-Martín, J-C Gutierrez-Pérez, D Torres-Lagares
BACKGROUND: The study of osteoblasts and their osteogenic functions is essential in order to understand them and their applications in implantology. In this sense, this study try to study BMP-2 production and bone matrix deposition, in addition to other biological variables, in osteoblasts cultured on a rough double acid-etched titanium surface (Osseotite®, Biomet 3i, Palm Beach Garden, Florida, USA) in comparison to a smooth titanium surface (machined) and a control Petri dish. MATERIALS AND METHODS: An in vitro prospective study...
August 15, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/28806597/a-nested-multivariate-chemometrics-based-calibration-strategy-for-direct-trace-biometal-analysis-in-soft-tissue-utilizing-energy-dispersive-x-ray-fluorescence-edxrf-and-scattering-spectrometry
#3
REVIEW
J J Okonda, K H Angeyo, J M Mangala, S M Kisia
Compton scatter-modulated fluorescence and multivariate chemometric (artificial neural network (ANN) and principal component regression (PCR)) calibration strategy was explored for direct rapid trace biometals (Mn, Fe, Cu, Zn, Se) analysis in "complex" matrices (model soft tissues). This involved spectral feature selection (multiple fluorescence signatures) normalized to or in conjunction with Compton scatter. ANN model resulted in more accurate trace biometal determination (R(2)>0.9) compared to PCR. Hybrid nested (ANN and PCR) approach led to optimized accurate biometals' concentrations in Oyster tissue (≤ ± 10%)...
August 8, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28806400/changes-in-the-anterior-segment-after-cycloplegia-with-a-biometer-using-swept-source-optical-coherence-tomography
#4
Tomoaki Higashiyama, Maki Iwasa, Masahito Ohji
The aim of this study was to investigate changes in the anterior segment of the eye after cycloplegia. A biometer combined with swept-source optical coherence tomography (SSOCT) was used for measurements. Patients with strabismus or amblyopia who underwent cycloplegia were included. The axial length, central corneal thickness, anterior chamber depth, and lens thickness were measured with the biometer-SSOCT system before and after cycloplegia. Altogether, 10 eyes of 10 patients (mean age 7.20 ± 3.08 years, range 4-14 years) were evaluated...
2017: PloS One
https://www.readbyqxmd.com/read/28800459/novel-cinnamamide-dibenzylamine-hybrids-potent-neurogenic-agents-with-antioxidant-cholinergic-and-neuroprotective-properties-as-innovative-drugs-for-alzheimer-s-disease
#5
Jin Wang, Pei Cai, Xue-Lian Yang, Fan Li, Jia-Jia Wu, Ling-Yi Kong, Xiao-Bing Wang
By using fragments endowed with interesting and complementary properties for the treatment of Alzheimer's disease (AD), a novel series of cinnamamide-dibenzylamine hybrids have been designed, synthesized, and evaluated biologically. In vitro assay indicated that most of the target compounds exhibited a significant ability to inhibit ChEs, strong potency inhibitory of self-induced β-amyloid (Aβ) aggregation and to act as potential antioxidants and biometal chelators. A Lineweaver-Burk plot and molecular modeling study showed that compound 7f targeted both the CAS and PAS of AChE...
August 1, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28795073/biomechanical-comparison-of-a-first-and-a-second-generation-all-soft-suture-glenoid-anchor
#6
John Erickson, Frank Chiarappa, Jonathan Haskel, Justin Rice, Adam Hyatt, James Monica, Aman Dhawan
BACKGROUND: All-soft tissue suture anchors provide advantages of decreased removal of bone and decreased glenoid volume occupied compared with traditional tap or screw-in suture anchors. Previous published data have led to biomechanical concerns with the use of first-generation all-soft suture anchors. PURPOSE/HYPOTHESIS: The purpose of this study was to evaluate the load to 2-mm displacement and ultimate load to failure of a second-generation all-soft suture anchor, compared with a first-generation anchor and a traditional PEEK (polyether ether ketone) anchor...
July 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28773240/metallic-biomaterials-current-challenges-and-opportunities
#7
REVIEW
Karthika Prasad, Olha Bazaka, Ming Chua, Madison Rochford, Liam Fedrick, Jordan Spoor, Richard Symes, Marcus Tieppo, Cameron Collins, Alex Cao, David Markwell, Kostya Ken Ostrikov, Kateryna Bazaka
Metallic biomaterials are engineered systems designed to provide internal support to biological tissues and they are being used largely in joint replacements, dental implants, orthopaedic fixations and stents. Higher biomaterial usage is associated with an increased incidence of implant-related complications due to poor implant integration, inflammation, mechanical instability, necrosis and infections, and associated prolonged patient care, pain and loss of function. In this review, we will briefly explore major representatives of metallic biomaterials along with the key existing and emerging strategies for surface and bulk modification used to improve biointegration, mechanical strength and flexibility of biometals, and discuss their compatibility with the concept of 3D printing...
July 31, 2017: Materials
https://www.readbyqxmd.com/read/28763209/hydrolysis-of-ammonia-borane-over-ni-zif-8-nanocatalyst-high-efficiency-mechanism-and-controlled-hydrogen-release
#8
Changlong Wang, Jimena Tuninetti, Zhao Wang, Chen Zhang, Roberto Ciganda, Lionel Salmon, Sergio Moya, Jaime Ruiz, Didier Astruc
Non-noble metal nanoparticles are notoriously difficult to prepare and stabilize with appropriate dispersion, which in turn severely limits their catalytic functions. Here, using zeolitic imidazolate framework (ZIF-8) as MOF template, catalytically remarkably efficient ligand-free first-row late transition-metal nanoparticles are prepared and compared. Upon scrutiny of the catalytic principles in the hydrolysis of ammonia-borane, the highest total turnover frequency among these first-row late transition metals is achieved for the templated Ni nanoparticles with 85...
August 11, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28758652/metallomics-the-history-over-the-last-decade-and-a-future-outlook
#9
Hiroki Haraguchi
In 2004, the term "metallomics" was coined to describe integrated biometal science (H. Haraguchi, Metallomics as Integrated Biometal Science, J. Anal. At. Spectrom., 2004, 19, 5-14). Around 10 years have passed since then, and the history of metallomics over the last decade is reviewed here, discussing the development of metallomics before and after the proposal. Furthermore, the future outlook of metallomics research will be considered, in terms of topics such as the organization of platforms for metallomics research related to trace metal sciences, a simplified model of the biological system and omics-sciences, research subjects in metallomics, recent trends of metallomics research, and the challenge of single biological cell analysis...
August 16, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28751933/the-central-role-of-biometals-maintains-oxidative-balance-in-the-context-of-metabolic-and-neurodegenerative-disorders
#10
REVIEW
Michal Pokusa, Alžbeta Kráľová Trančíková
Traditionally, oxidative stress as a biological aspect is defined as an imbalance between the free radical generation and antioxidant capacity of living systems. The intracellular imbalance of ions, disturbance in membrane dynamics, hypoxic conditions, and dysregulation of gene expression are all molecular pathogenic mechanisms closely associated with oxidative stress and underpin systemic changes in the body. These also include aspects such as chronic immune system activation, the impairment of cellular structure renewal, and alterations in the character of the endocrine secretion of diverse tissues...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28751180/outcomes-of-office-based-temporomandibular-joint-arthroscopy-a-5-year-retrospective-study
#11
R H Hossameldin, J P McCain
Temporomandibular joint (TMJ) arthroscopy is a minimally invasive surgical approach for intra-articular TMJ diseases. Office-based arthroscopy using the smallest TMJ scope allows for good visualization, as well as the ability to lavage the joint in an office setting. This study aimed to assess the efficacy of an office-based TMJ arthroscopic technique. A retrospective evaluation of 363 patients with a TMJ disorder was performed. These patients underwent office-based arthroscopy using the OnPoint 1.2mm Scope System (Biomet Microfixation, Jacksonville, FL, USA) in Florida, USA, from July 2007...
July 24, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28750856/readability-of-patient-education-materials-from-the-web-sites-of-orthopedic-implant-manufacturers
#12
Meghan M Yi, Paul H Yi, Khalil I Hussein, Michael B Cross, Craig J Della Valle
BACKGROUND: Prior studies indicate that orthopedic patient education materials are written at a level that is too high for the average patient. The purpose of this study was to assess the readability of online patient education materials provided by orthopedic implant manufacturers. METHODS: All patient education articles available in 2013 from the web sites of the 5 largest orthopedic implant manufacturers were identified. Each article was evaluated with the Flesch-Kincaid (FK) readability test...
July 11, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28726133/iron-protects-porcine-plasma-coagulation-kinetics-from-degradation-by-crotalus-atrox-venom
#13
Christine S Olver, Vance G Nielsen
While the administration of antivenom to treat hemotoxic snake bite injury remains the gold standard of therapy, we have demonstrated that modifying human fibrinogen with iron and carbon monoxide renders it resistant to fibrinogenolytic snake venom enzymes. In order to translate these findings into a possible biometal-based therapy complementary to antivenom administration, a preclinical model that possesses fibrinogen that closely mimics the human molecule in response to iron and carbon monoxide needed to be identified...
July 19, 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/28678834/normative-database-for-separate-inner-retinal-layers-thickness-using-spectral-domain-optical-coherence-tomography-in-caucasian-population
#14
María Nieves-Moreno, Jose M Martínez-de-la-Casa, Pilar Cifuentes-Canorea, Marina Sastre-Ibáñez, Enrique Santos-Bueso, Federico Sáenz-Francés, Laura Morales-Fernández, Julián García-Feijoó
PURPOSE: Develop the first normative database of the thickness of every inner retinal layer in the macular area in a healthy, Caucasian population between 18 to 87 years old, using Spectralis Optical Coherence Tomography (OCT). METHODS: On this transversal, observational study, 300 patients between 18 to 87 years old and without an ophthalmological condition were recruited. Macular OCT scans were performed on all patients (Spectralis OCT, Heidelberg Engineering)...
2017: PloS One
https://www.readbyqxmd.com/read/28671127/radiopharmaceuticals-for-assessment-of%C3%A2-altered-metabolism-and-biometal-fluxes-in%C3%A2-brain-aging-and-alzheimer-s-disease-with%C3%A2-positron-emission-tomography
#15
Fang Xie, Fangyu Peng
Aging is a risk factor for Alzheimer's disease (AD). There are changes of brain metabolism and biometal fluxes due to brain aging, which may play a role in pathogenesis of AD. Positron emission tomography (PET) is a versatile tool for tracking alteration of metabolism and biometal fluxes due to brain aging and AD. Age-dependent changes in cerebral glucose metabolism can be tracked with PET using 2-deoxy-2-[18F]-fluoro-D-glucose (18F-FDG), a radiolabeled glucose analogue, as a radiotracer. Based on different patterns of altered cerebral glucose metabolism, 18F-FDG PET was clinically used for differential diagnosis of AD and Frontotemporal dementia (FTD)...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28643709/comparison-of-central-corneal-thickness-with-four-noncontact-devices-an-agreement-analysis-of-swept-source-technology
#16
Erhan Ozyol, Pelin Özyol
PURPOSE: The purpose of this study was to compare the central corneal thickness (CCT) measurements of four noncontact devices in healthy eyes. MATERIALS AND METHODS: In a sample of 45 healthy controls, CCT was measured using an optical biometer (IOLMaster 700) based on swept-source optical coherence tomography (SS-OCT), high-resolution rotating Scheimpflug camera system (Pentacam HR), spectral-domain OCT (SD-OCT) device with an anterior segment module (Spectralis), and noncontact pachymetry (NCP) device (Topcon TRK-2P)...
June 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28622559/controlling-sunbathing-safety-during-the-summer-holidays-the-solar-uv-campaign-at-baltic-sea-coast-in-2015
#17
Jakub Guzikowski, Agnieszka E Czerwińska, Janusz W Krzyścin, Michał A Czerwiński
Information regarding the intensity of surface UV radiation, provided for the public, is frequently given in terms of a daily maximum UV Index (UVI), based on a prognostic model. The quality of the UV forecast depends on the accuracy of column amount of ozone and cloudiness prediction. Daily variability of UVI is needed to determine the risk of the UV overexposure during outdoor activities. Various methods of estimating the temporary UVI and the maximum duration of UV exposures (received a dose equal to minimal erythemal dose - MED), at the site of sunbathing, were compared...
April 8, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28606638/retrospective-cohort-study-on-radial-head-replacements-comparing-results-between-smooth-and-porous-stem-designs
#18
Mélissa Laflamme, Pierre-Philippe Grenier-Gauthier, Alexandre Leclerc, Stéphanie Antoniades, Anne-Marie Bédard
BACKGROUND: When necessary, radial head integrity after a fracture can be re-created by the use of a radial head arthroplasty if the radial head is judged irreparable. The purpose of this study was to compare the clinical and radiographic outcomes of metal modular radial head replacements with a smooth vs. a porous stem. METHODS: A retrospective cohort study of radial head replacements performed in the first 4 weeks after a trauma in an adult patient at our institution between 2000 and 2014 was completed...
August 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28593060/fracture-of-the-tibial-baseplate-16-years-after-miller-galante-ii-total-knee-arthroplasty
#19
Kazuaki Mineta, Masahiko Okada, Soshi Matsumoto, Daisuke Hamada, Tomohiro Goto, Koichi Sairyo
We report a rare case of tibial baseplate fracture of Miller-Galante II (MG II) prosthesis. We examine the factors that may cause such late fracture and review the literature on radiographic analysis and retrieval studies. A 76-year-old woman, who had undergone bilateral MG II total knee arthroplasty due to rheumatoid arthritis 16 years earlier, presented to our department with a 3-month history of left knee pain. Plain radiographs revealed severe distortion of the medial tibial component. During revision knee arthroplasty, we observed severe metallosis in the knee joint, polyethylene insert deformation, and posteromedial coronal baseplate fracture...
2017: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/28578684/metal-on-metal-hip-resurfacing-in-patients-younger-than-50%C3%A2-years-a-retrospective-analysis-1285-cases-12-year-survivorship
#20
Melissa D Gaillard, Thomas P Gross
BACKGROUND: The Nordic registry reports patients under 50 years old with total hip replacements realize only 83% 10-year implant survivorship. These results do not meet the 95% 10-year survivorship guideline posed by the UK's National Institute for Health and Care Excellence (NICE) in 2014. METHODS: The purpose of this study is threefold: First, we evaluate if metal-on-metal hip resurfacing arthroplasty meets these high standards in younger patients. Next, we compare outcomes between age groups to determine if younger patients are at higher risk for revision or complication...
June 2, 2017: Journal of Orthopaedic Surgery and Research
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