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https://www.readbyqxmd.com/read/28072898/three-year-results-with-a-ringless-third-generation-porous-plasma-sprayed-acetabular-component-in-primary-total-hip-arthroplasty
#1
Keith R Berend, Joanne B Adams, Michael J Morris, Adolph V Lombardi
INTRODUCTION: We previously reported promising early results in patients undergoing primary total hip arthroplasty (THA) with a third-generation cementless acetabular system that has a porous plasma-sprayed coating on a titanium alloy substrate shell, a ringless barb and groove locking mechanism, and a vitamin E-infused highly crosslinked polyethylene insert. The purpose of this study was to examine the outcomes and need for revision in a subset of patients previously reviewed who now have potential for three-year follow-up...
January 10, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/28060023/impact-of-second-stage-surgery-on-bone-remodeling-around-new-hybrid-titanium-implants-a-prospective-clinical-study-in-humans
#2
Tonino Traini, Marco Berardini, Francesca Congedi, Bruna Sinjari, Paolo Trisi, Sergio Caputi
OBJECTIVE: The present prospective study aimed to more precisely identify the time points of bone changes around hybrid titanium implants up to 30 months of follow-up. MATERIALS AND METHODS: Twelve hybrid T3 implants (Biomet 3i) were placed in 9 healthy patients with the 2-stage surgical approach. Standardized digital Rx were taken at implant insertion (T0); healing-abutment connection after 3.1 ± 0.2 weeks (TX); loading stage after 7.5 ± 0.6 weeks (T1); after 12 months (T2); and after 30 months (T3) of functional loading...
January 4, 2017: Implant Dentistry
https://www.readbyqxmd.com/read/28050321/comparison-of-anterior-segment-measurements-obtained-by-aladdin-optical-biometer-and-sirius-corneal-topography
#3
Onur Polat, Zeki Baysal, Serkan Özcan, Sibel İnan, Ümit Übeyt İnan
OBJECTIVES: To assess the agreement of anterior segment parameter measurements derived from Aladdin optical biometer using optical low coherence interferometer and Sirius corneal topography using combined Scheimpflug-Placido disk. MATERIALS AND METHODS: Data obtained using the Aladdin and Sirius systems from 110 eyes of 59 subjects who had no health problems other than refractive errors were retrospectively evaluated. Anterior chamber depth (ACD), flat (K1) and steep (K2) keratometry readings, and white-to-white distance (WTW) measurements taken with both devices were noted...
December 2016: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28011206/design-synthesis-and-biological-evaluation-of-4-aminochalcone-rivastigmine-hybrids-as-multifunctional-agents-for-the-treatment-of-alzheimer-s-disease
#4
Ganyuan Xiao, Yan Li, Xiaoming Qiang, Rui Xu, Yunxiaozhu Zheng, Zhongcheng Cao, Li Luo, Xia Yang, Zhipei Sang, Fu Su, Yong Deng
A series of 4'-aminochalcone-revastigmine hybrids were designed, synthesized and evaluated as multifunctional agents for the treatment of Alzheimer's disease. The results showed that most of these compounds exhibited good multifunctional activities. In particular, compound 6c displayed the best inhibitory potency on acetylcholinesterase (IC50=4.91μM), and significant antioxidative activity with a value 2.83-fold of Trolox. The kinetic analysis of AChE inhibition revealed that 6c showed mixed-type inhibition, binding simultaneously to the catalytic active site and peripheral anionic site of AChE...
December 9, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28007638/immunotoxicological-effects-of-arsenic-bioaccumulation-on-spatial-metallomics-and-cellular-enzyme-response-in-the-spleen-of-male-wistar-rats-after-oral-intake
#5
Elio A Soria, Roberto D Pérez, Ignasi Queralt, Carlos A Pérez, Guillermina A Bongiovanni
Arsenic (As) is a worldwide environmental contaminant, which compromises immunity and causes various associated disorders. To further investigate its immunotoxicity, male Wistar rats were exposed to 100ppm of sodium arsenite (inorganic AsIII) in drinking water for 2 months. Given that metals are significant immune regulators, their content and distribution were analysed in spleen tissues, to then evaluate subsequent changes of redox enzyme responses in spleen parenchyma cells (splenocytes). X-ray fluorescence spectrometry demonstrated As accumulation in both white and red pulps (p<0...
January 15, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/27999295/special-issue-molecules-against-alzheimer
#6
EDITORIAL
Michael Decker, Diego Muñoz-Torrero
This Special Issue, entitled "Molecules against Alzheimer", gathers a number of original articles, short communications, and review articles on recent research efforts toward the development of novel drug candidates, diagnostic agents and therapeutic approaches for Alzheimer's disease (AD), the most prevalent neurodegenerative disorder and a leading cause of death worldwide. This Special Issue contains many interesting examples describing the design, synthesis, and pharmacological profiling of novel compounds that hit one or several key biological targets, such as cholinesterases, β-amyloid formation or aggregation, monoamine oxidase B, oxidative stress, biometal dyshomeostasis, mitochondrial dysfunction, serotonin and/or melatonin systems, the Wnt/β-catenin pathway, sigma receptors, nicotinamide phosphoribosyltransferase, or nuclear erythroid 2-related factor...
December 16, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27994390/comparison-of-anterior-segment-measurements-with-optical-low-coherence-reflectometry-and-partial-coherence-interferometry-optical-biometers
#7
Ertuğrul Can, Mustafa Duran, Tuğba Çetinkaya, Nurşen Arıtürk
AIMS: To evaluate a new noncontact optical biometer using partial-coherence interferometry and to compare the clinical measurements with those obtained from the device using optical low-coherence reflectometry (OLCR). SETTING AND DESIGN: Ondokuz Mayis University, Samsun, Turkey. Nonrandomized, prospective clinical trial. SUBJECTS AND METHODS: The study was performed on the healthy phakic eyes of volunteers in the year 2014. Measurements of axial length (AL), anterior chamber depth (ACD), central corneal thickness (CCT), mean keratometry (K), and white-to-white (WTW) measurements obtained with the low-time coherence interferometry (LTCI) were compared with those obtained with the OLCR...
October 2016: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/27951485/aurone-mannich-base-derivatives-as-promising-multifunctional-agents-with-acetylcholinesterase-inhibition-anti-%C3%AE-amyloid-aggragation-and-neuroprotective-properties-for-the-treatment-of-alzheimer-s-disease
#8
Yan Li, Xiaoming Qiang, Li Luo, Xia Yang, Ganyuan Xiao, Qi Liu, Jiachen Ai, Zhenghuai Tan, Yong Deng
A series of aurone Mannich base derivatives were designed, synthesized and evaluated as multifunctional agents for the treatment of Alzheimer's disease. In vitro assays demonstrated that most of the derivatives were selective AChE inhibitors with good multifunctional properties. Among them, compound 7d exhibited outstanding inhibitory activity for RatAChE, EeAChE and HuAChE (IC50 = 0.00878 ± 0.0002 μM, 0.0212 ± 0.006 μM and 0.0371 ± 0.004 μM, respectively). Moreover, 7d displayed high antioxidant activity and could confer significant neuroprotective effect against H2O2-induced PC-12 cell injury...
December 5, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27924742/dual-mobility-total-hip-replacement-in-a-high-risk-population
#9
Jatinder Singh Luthra, Amur Al Riyami, Mohamad Kasim Allami
OBJECTIVE: The purpose of the study was to evaluate results of dual mobility total replacement in a high risk population who take hip into hyperflexed position while sitting and praying on the floor. METHOD: The study included 65 (35 primary total replacement and 30 complex total hip replacement) cases of total hip replacement using avantage privilege dual mobility cup system from biomet. A cemented acetabular component and on femoral side a bimetric stem, either cemented or uncemented used depending on the canal type...
2016: SICOT-J
https://www.readbyqxmd.com/read/27923535/multitarget-drug-design-strategy-against-alzheimer-s-disease-homoisoflavonoid-mannich-base-derivatives-serve-as-acetylcholinesterase-and-monoamine-oxidase-b-dual-inhibitors-with-multifunctional-properties
#10
Yan Li, Xiaoming Qiang, Li Luo, Xia Yang, Ganyuan Xiao, Yunxiaozhu Zheng, Zhongcheng Cao, Zhipei Sang, Fu Su, Yong Deng
A series of homoisoflavonoid Mannich base derivatives were designed, synthesized and evaluated as multifunctional agents against Alzheimer's disease. It demonstrated that most of the derivatives were selective AChE and MAO-B dual inhibitors with good multifunctional properties. Among them, compound 10d displayed the comprehensive advantages, with excellent AChE and MAO-B inhibitory activities (IC50=2.49±0.08nM and 1.74±0.0581μM, respectively), good self- and Cu(2+)-induced Aβ1-42 aggregation inhibitory potency, antioxidant activity, biometal chelating ability and high BBB permeability...
January 15, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/27900479/evaluation-of-the-repeatability-of-a-swept-source-ocular-biometer-for-measuring-ocular-biometric-parameters
#11
Teresa Ferrer-Blasco, Alberto Domínguez-Vicent, José J Esteve-Taboada, Miguel A Aloy, Jose E Adsuara, Robert Montés-Micó
PURPOSE: The purpose was to evaluate the repeatability of a new swept-source optical biometer for measuring ocular biometric parameters. METHODS: Thirty subjects with healthy and phakic eyes were included in this study, and only one eye per participant was analysed. Each eye was measured five times with the IOLMaster 700 swept-source optical biometer (Carl Zeiss Meditec, Jena, Germany). Axial length (AL), anterior chamber depth (ACD), central corneal thickness (CCT), lens thickness (LT), white-to-white (WTW), and K1 and K2 keratometric readings were evaluated...
November 30, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/27894148/catastrophic-failure-of-regenerex-tibial-components-a-case-series
#12
Gavin Stormont, Daniel Stormont
The aim of this study was to analyze short-term metal failures in well-placed Signature-guided Regenerex (Zimmer Biomet, Warsaw, IN) tibial components in a limited patient series. A retrospective, consecutive, nonrandomized, unblinded study from a limited cohort of young active osteoarthritis patients was conducted. All cases received a Regenerex tibial component which we evaluated for metal failure. Patients met the then current indications from the Center for Medicare and Medicaid Services Guidelines for knee replacement...
November 28, 2016: Journal of Knee Surgery
https://www.readbyqxmd.com/read/27876531/patient-centered-quality-of-life-measures-after-alloplastic-temporomandibular-joint-replacement-surgery
#13
X Alakailly, D Schwartz, N Alwanni, C Demko, M A Altay, Y Kilinc, D A Baur, F Quereshy
The purpose of this study was to evaluate patient-reported outcome measures of quality of life (QoL) for patients with end-stage temporomandibular joint (TMJ) disease who have undergone TMJ prosthetic replacement. The records of 36 patients who had undergone alloplastic total joint replacement procedures were analyzed. Patients were treated using either TMJ Concepts or Biomet/Lorenz prosthetics. Patients were asked to complete a 12-item TMJ-S-QoL survey, which encompassed questions pertaining to pain, speech, chewing function, and various aspects of social life and mental health...
February 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27843285/clinical-outcomes-with-toric-intraocular-lenses-planned-using-an-optical-low-coherence-reflectometry-ocular-biometer-with-a-new-toric-calculator
#14
Kjell G Gundersen, Richard Potvin
PURPOSE: To prospectively evaluate postoperative clinical outcomes with implantation of toric intraocular lenses (IOLs) using preoperative keratometry from an optical low coherence reflectometry (OLCR) ocular biometer (Lenstar(®) LS900) and the built-in Barrett toric calculator. PATIENTS AND METHODS: A prospective observational study recruited one or both eyes of subjects who underwent uncomplicated cataract surgery with toric IOL implantation using OLCR biometery data and the Barrett toric IOL calculator for toric IOL planning...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27834962/agreement-and-clinical-comparison-between-a-new-swept-source-optical-coherence-tomography-based-optical-biometer-and-an-optical-low-coherence-reflectometry-biometer
#15
P Arriola-Villalobos, J Almendral-Gómez, N Garzón, J Ruiz-Medrano, C Fernández-Pérez, J M Martínez-de-la-Casa, D Díaz-Valle
PurposeTo compare measurements taken using a swept-source optical coherence tomography-based optical biometer (IOLmaster 700) and an optical low-coherence reflectometry biometer (Lenstar 900), and to determine the clinical impacts of differences in their measurements on intraocular lens (IOL) power predictions.MethodsEighty eyes of 80 patients scheduled to undergo cataract surgery were examined with both biometers. The measurements made using each device were axial length (AL), central corneal thickness (CCT), aqueous depth (AQD), lens thickness (LT), mean keratometry (MK), white-to-white distance (WTW), and pupil diameter (PD)...
November 11, 2016: Eye
https://www.readbyqxmd.com/read/27833928/comparison-of-a-new-optical-biometer-and-a-standard-biometer-in-cataract-patients
#16
Pipat Kongsap
BACKGROUND: Cataract surgery is the most common surgical procedure in ophthalmology. Biometry data and accurate intraocular lens (IOL) calculations are very important in achieving the desired refractive outcomes. The aim of this study was to compare measurements using a new optical low coherence reflectometry (OLCR) biometer (OA-2000) and the gold standard partial coherence interferometry (PCI) optical biometer (IOLMaster 500). METHODS: Ocular biometry of cataract patients were measured by the OA-2000 and IOLMaster 500 to compare keratometry (K), axial length (AL), anterior chamber depth (ACD), white-to-white (WTW) diameter, and IOL power using the SRK/T formula...
2016: Eye and Vision (London, England)
https://www.readbyqxmd.com/read/27800269/early-postoperative-effects-of-cataract-surgery-on-anterior-segment-parameters-in-primary-open-angle-glaucoma-and-pseudoexfoliation-glaucoma
#17
Ufuk Elgin, Emine Şen, Tülay Şimşek, Kemal Tekin, Pelin Yılmazbaş
OBJECTIVES: To compare the effect of cataract surgery on anterior segment parameters measured by optical biometry in primary open-angle glaucoma (POAG) and pseudoexfoliation glaucoma (PXG). MATERIALS AND METHODS: Twenty-five eyes of 25 patients with POAG and 29 eyes of 29 patients with PXG who had uncomplicated phacoemulsification and posterior chamber intraocular lens implantation surgery were included to our prospective study. Central corneal thickness (CCT), anterior chamber depth (ACD) and axial length (AL) were measured with an optical biometer preoperatively and at 1 month postoperatively...
June 2016: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/27798203/analysis-of-linezolid-and-tigecycline-as-candidates-for-local-prophylaxis-via-antibiotic-loaded-bone-cement
#18
T Nichol, T J Smith, R Townsend, I Stockley, R Akid
OBJECTIVES: To assess the Gram-positive-specific antibiotic linezolid and the broad-spectrum antibiotic tigecycline for use in local antibiotic delivery via antibiotic-loaded bone cement. METHODS: Linezolid and tigecycline were added to Biomet bone cement at varying concentrations. Antibiotic elution over 1 week was quantified by HPLC-MS. The effect of wear on elution over 51 h was determined using a modified TE-66 wear tester. Eluted antibiotics were used to determine the MICs for a panel of clinically relevant bacteria...
October 21, 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27793471/effect-of-pharmacological-pupil-dilation-on-measurements-and-iol-power-calculation-made-using-the-new-swept-source-optical-coherence-tomography-based-optical-biometer
#19
P Arriola-Villalobos, J Almendral-Gómez, N Garzón, J Ruiz-Medrano, C Fernández-Pérez, J M Martínez-de-la-Casa, D Díaz-Valle
PURPOSE: To determine whether pupil dilation affects biometric measurements and intraocular lens (IOL) power calculation made using the new swept-source optical coherence tomography-based optical biometer (IOLMaster 700(©); Carl Zeiss Meditec, Jena, Germany). PROCEDURES: Eighty-one eyes of 81 patients evaluated for cataract surgery were prospectively examined using the IOLMaster 700(©) before and after pupil dilation with tropicamide 1%. The measurements made were: axial length (AL), central corneal thickness (CCT), aqueous chamber depth (ACD), lens thickness (LT), mean keratometry (MK), white-to-white distance (WTW) and pupil diameter (PD)...
December 2016: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/27780349/early-experience-with-vitamin-e-antioxidant-infused-highly-cross-linked-polyethylene-inserts-in-primary-total-knee-arthroplasty
#20
Emilie M Flament, Keith R Berend, Jason M Hurst, Michael J Morris, Joanne B Adams, Adolph V Lombardi
BACKGROUND: In past decades, polyethylene wear was a major cause of failure in total knee arthroplasty (TKA). Polyethylene for use in arthroplasty has been vastly improved in recent years, with improved materials as well as manufacturing and sterilization processes. Testing has shown that infusion of vitamin E prevents oxidative degradation of polyethylene without remelting, allowing the material to maintain mechanical properties and wear resistance over time. The purpose of this study is to review the early result of patients undergoing primary TKA with vitamin E antioxidant-infused polyethylene inserts...
October 26, 2016: Surgical Technology International
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