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https://www.readbyqxmd.com/read/28889269/copper-and-alzheimer-s-disease
#1
Zoe K Mathys, Anthony R White
Alzheimer's disease (AD) is the most common form of adult neurode-generation and is characterised by progressive loss of cognitive function leading to death. The neuropathological hallmarks include extracellular amyloid plaque accumulation in affected regions of the brain, formation of intraneuronal neurofibrillary tangles, chronic neuroinflammation, oxidative stress, and abnormal biometal homeostasis. Of the latter, major changes in copper (Cu) levels and localisation have been identified in AD brain, with accumulation of Cu in amyloid deposits, together with deficiency of Cu in some brain regions...
2017: Advances in Neurobiology
https://www.readbyqxmd.com/read/28870873/the-kinematic-alignment-technique-for-tka-reliably-aligns-the-femoral-component-with-the-cylindrical-axis
#2
Charles Riviere, FarhadIranpour, Simon Harris, Edouard Auvinet, ArashAframian, Patrick Chabrand, Justin Cobb
INTRODUCTION: Kinematic alignment (KA) technique is an alternative technique for positioning a TKA, which aims a patient-specific implant positioning in order to reproduce the pre-arthritic knee anatomy. Because reliability in implant positioning is of interest to obtain reproducible good functional results, our study tests the hypothesis that the medial and lateral distal and posterior positions of the planned and surgically implantedkinematically aligned femoralcomponentare similar...
September 1, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28869469/trehalose-improves-cognition-in-the-transgenic-tg2576-mouse-model-of%C3%A2-alzheimer-s-disease
#3
Stuart D Portbury, Dominic J Hare, Charlotte Sgambelloni, Kali Perronnes, Ashley J Portbury, David I Finkelstein, Paul A Adlard
This study assessed the therapeutic utility of the autophagy enhancing stable disaccharide trehalose in the Tg2576 transgenic mouse model of Alzheimer's disease (AD) via an oral gavage of a 2% trehalose solution for 31 days. Furthermore, as AD is a neurodegenerative condition in which the transition metals, iron, copper, and zinc, are understood to be intricately involved in the cellular cascades leading to the defining pathologies of the disease, we sought to determine any parallel impact of trehalose treatment on metal levels...
August 30, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28843402/temporomandibular-joint-reconstruction-with-stock-and-custom-made-devices-indications-and-results-of-a-14-year-experience
#4
Giovanni Gerbino, Emanuele Zavattero, Gianfranco Bosco, Sid Berrone, Guglielmo Ramieri
PURPOSE: Temporomandibular joint (TMJ) reconstruction with alloplastic implants is a reliable, safe and effective treatment option for selected debilitating pathologies of the TMJ. This study retrospectively analyzes our 14-year experience in total alloplastic reconstruction of the TMJ using stock and custom Biomet prostheses. Indications, results and rationale for the choice of stock and custom-made devices are discussed. MATERIAL AND METHODS: Patients were enrolled in the study who underwent single-stage alloplastic total joint replacement from January 2000 to October 2014...
August 1, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28837626/trehalose-improves-traumatic-brain-injury-induced-cognitive-impairment
#5
Stuart D Portbury, Dominic J Hare, David I Finkelstein, Paul A Adlard
Traumatic brain Injury (TBI) is a significant cause of death and long-term disability for which there are currently no effective pharmacological treatment options. In this study then, we utilized a mouse model of TBI to assess the therapeutic potential of the stable disaccharide trehalose, which is known to protect against oxidative stress, increase levels of chaperone molecules and enhance autophagy. Furthermore, trehalose has demonstrated neuroprotective properties in numerous animal models and has been proposed as a potential treatment for neurodegeneration...
2017: PloS One
https://www.readbyqxmd.com/read/28834818/agreement-of-corneal-diameter-measurements-obtained-by-a-swept-source-biometer-and-a-scheimpflug-based-topographer
#6
Ramin Salouti, Mohammad Hossein Nowroozzadeh, Zahra Tajbakhsh, Mansoureh Bagheri, Maryam Ghoreyshi, Monir Azizzadeh, Mohammad Reza Razeghinejad
PURPOSE: To assess the agreement between a swept-source optical biometry device (IOLMaster 700) and a Scheimpflug-based topography device (Pentacam HR) in measuring the corneal diameter. METHODS: A total of 100 eyes from 100 cataract surgery candidates were enrolled. The white-to-white (WTW) distance measurements provided by both devices were recorded and analyzed. A paired t test was performed to compare the mean values of the WTW distance between the IOLMaster 700 and Pentacam HR...
August 22, 2017: Cornea
https://www.readbyqxmd.com/read/28816194/risk-factors-associated-with-dental-implant-failure-a-study-of-302-implants-placed-in-a-regional-center
#7
Mehmet Oztel, Wojciech M Bilski, Arthur Bilski
AIM: The aim of this research is to determine which risk factors are associated with dental implant failure and survival. MATERIALS AND METHODS: Data pertaining to patients who received one or more dental implants from 2011 to 2013 in a regional center were retrospectively reviewed. This included a total of 302 Biomet 3i NanoTite Tapered Certain implants placed in 177 patients. All patients were followed up until the end of 2015. RESULTS: This study found an overall success rate of 95%...
August 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28811866/preliminary-data-on-the-interaction-between-some-biometals-and-oxidative-stress-status-in-mild-cognitive-impairment-and-alzheimer-s-disease-patients
#8
Ioana-Miruna Balmuș, Stefan-Adrian Strungaru, Alin Ciobica, Mircea-Nicusor Nicoara, Romeo Dobrin, Gabriel Plavan, Cristinel Ștefănescu
Increased interest regarding the biometal mechanisms of action and the pathways in which they have regulatory roles was lately observed. Particularly, it was shown that biometal homeostasis dysregulation may lead to neurodegeneration including Alzheimer's disease, Parkinson disease, or prion protein disease, since important molecular signaling mechanisms in brain functions implicate both oxidative stress and redox active biometals. Oxidative stress could be a result of a breakdown in metal-ion homeostasis which leads to abnormal metal protein chelation...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28809380/production-of-bone-mineral-material-and-bmp-2-in-osteoblasts-cultured-on-double-acid-etched-titanium
#9
R Velázquez-Cayón, G Castillo-Dalí, J-R Corcuera-Flores, M-A Serrera-Figallo, R Castillo-Oyagüe, M González-Martín, J-C Gutierrez-Pérez, D Torres-Lagares
BACKGROUND: The study of osteoblasts and their osteogenic functions is essential in order to understand them and their applications in implantology. In this sense, this study try to study BMP-2 production and bone matrix deposition, in addition to other biological variables, in osteoblasts cultured on a rough double acid-etched titanium surface (Osseotite®, Biomet 3i, Palm Beach Garden, Florida, USA) in comparison to a smooth titanium surface (machined) and a control Petri dish. MATERIALS AND METHODS: An in vitro prospective study...
August 15, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/28806597/a-nested-multivariate-chemometrics-based-calibration-strategy-for-direct-trace-biometal-analysis-in-soft-tissue-utilizing-energy-dispersive-x-ray-fluorescence-edxrf-and-scattering-spectrometry
#10
REVIEW
J J Okonda, K H Angeyo, J M Mangala, S M Kisia
Compton scatter-modulated fluorescence and multivariate chemometric (artificial neural network (ANN) and principal component regression (PCR)) calibration strategy was explored for direct rapid trace biometals (Mn, Fe, Cu, Zn, Se) analysis in "complex" matrices (model soft tissues). This involved spectral feature selection (multiple fluorescence signatures) normalized to or in conjunction with Compton scatter. ANN model resulted in more accurate trace biometal determination (R(2)>0.9) compared to PCR. Hybrid nested (ANN and PCR) approach led to optimized accurate biometals' concentrations in Oyster tissue (≤ ± 10%)...
August 8, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28806400/changes-in-the-anterior-segment-after-cycloplegia-with-a-biometer-using-swept-source-optical-coherence-tomography
#11
Tomoaki Higashiyama, Maki Iwasa, Masahito Ohji
The aim of this study was to investigate changes in the anterior segment of the eye after cycloplegia. A biometer combined with swept-source optical coherence tomography (SSOCT) was used for measurements. Patients with strabismus or amblyopia who underwent cycloplegia were included. The axial length, central corneal thickness, anterior chamber depth, and lens thickness were measured with the biometer-SSOCT system before and after cycloplegia. Altogether, 10 eyes of 10 patients (mean age 7.20 ± 3.08 years, range 4-14 years) were evaluated...
2017: PloS One
https://www.readbyqxmd.com/read/28800459/novel-cinnamamide-dibenzylamine-hybrids-potent-neurogenic-agents-with-antioxidant-cholinergic-and-neuroprotective-properties-as-innovative-drugs-for-alzheimer-s-disease
#12
Jin Wang, Pei Cai, Xue-Lian Yang, Fan Li, Jia-Jia Wu, Ling-Yi Kong, Xiao-Bing Wang
By using fragments endowed with interesting and complementary properties for the treatment of Alzheimer's disease (AD), a novel series of cinnamamide-dibenzylamine hybrids have been designed, synthesized, and evaluated biologically. In vitro assay indicated that most of the target compounds exhibited a significant ability to inhibit ChEs, strong potency inhibitory of self-induced β-amyloid (Aβ) aggregation and to act as potential antioxidants and biometal chelators. A Lineweaver-Burk plot and molecular modeling study showed that compound 7f targeted both the CAS and PAS of AChE...
August 1, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28795073/biomechanical-comparison-of-a-first-and-a-second-generation-all-soft-suture-glenoid-anchor
#13
John Erickson, Frank Chiarappa, Jonathan Haskel, Justin Rice, Adam Hyatt, James Monica, Aman Dhawan
BACKGROUND: All-soft tissue suture anchors provide advantages of decreased removal of bone and decreased glenoid volume occupied compared with traditional tap or screw-in suture anchors. Previous published data have led to biomechanical concerns with the use of first-generation all-soft suture anchors. PURPOSE/HYPOTHESIS: The purpose of this study was to evaluate the load to 2-mm displacement and ultimate load to failure of a second-generation all-soft suture anchor, compared with a first-generation anchor and a traditional PEEK (polyether ether ketone) anchor...
July 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28773240/metallic-biomaterials-current-challenges-and-opportunities
#14
REVIEW
Karthika Prasad, Olha Bazaka, Ming Chua, Madison Rochford, Liam Fedrick, Jordan Spoor, Richard Symes, Marcus Tieppo, Cameron Collins, Alex Cao, David Markwell, Kostya Ken Ostrikov, Kateryna Bazaka
Metallic biomaterials are engineered systems designed to provide internal support to biological tissues and they are being used largely in joint replacements, dental implants, orthopaedic fixations and stents. Higher biomaterial usage is associated with an increased incidence of implant-related complications due to poor implant integration, inflammation, mechanical instability, necrosis and infections, and associated prolonged patient care, pain and loss of function. In this review, we will briefly explore major representatives of metallic biomaterials along with the key existing and emerging strategies for surface and bulk modification used to improve biointegration, mechanical strength and flexibility of biometals, and discuss their compatibility with the concept of 3D printing...
July 31, 2017: Materials
https://www.readbyqxmd.com/read/28763209/hydrolysis-of-ammonia-borane-over-ni-zif-8-nanocatalyst-high-efficiency-mechanism-and-controlled-hydrogen-release
#15
Changlong Wang, Jimena Tuninetti, Zhao Wang, Chen Zhang, Roberto Ciganda, Lionel Salmon, Sergio Moya, Jaime Ruiz, Didier Astruc
Non-noble metal nanoparticles are notoriously difficult to prepare and stabilize with appropriate dispersion, which in turn severely limits their catalytic functions. Here, using zeolitic imidazolate framework (ZIF-8) as MOF template, catalytically remarkably efficient ligand-free first-row late transition-metal nanoparticles are prepared and compared. Upon scrutiny of the catalytic principles in the hydrolysis of ammonia-borane, the highest total turnover frequency among these first-row late transition metals is achieved for the templated Ni nanoparticles with 85...
August 11, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28758652/metallomics-the-history-over-the-last-decade-and-a-future-outlook
#16
Hiroki Haraguchi
In 2004, the term "metallomics" was coined to describe integrated biometal science (H. Haraguchi, Metallomics as Integrated Biometal Science, J. Anal. At. Spectrom., 2004, 19, 5-14). Around 10 years have passed since then, and the history of metallomics over the last decade is reviewed here, discussing the development of metallomics before and after the proposal. Furthermore, the future outlook of metallomics research will be considered, in terms of topics such as the organization of platforms for metallomics research related to trace metal sciences, a simplified model of the biological system and omics-sciences, research subjects in metallomics, recent trends of metallomics research, and the challenge of single biological cell analysis...
August 16, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28751933/the-central-role-of-biometals-maintains-oxidative-balance-in-the-context-of-metabolic-and-neurodegenerative-disorders
#17
REVIEW
Michal Pokusa, Alžbeta Kráľová Trančíková
Traditionally, oxidative stress as a biological aspect is defined as an imbalance between the free radical generation and antioxidant capacity of living systems. The intracellular imbalance of ions, disturbance in membrane dynamics, hypoxic conditions, and dysregulation of gene expression are all molecular pathogenic mechanisms closely associated with oxidative stress and underpin systemic changes in the body. These also include aspects such as chronic immune system activation, the impairment of cellular structure renewal, and alterations in the character of the endocrine secretion of diverse tissues...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28751180/outcomes-of-office-based-temporomandibular-joint-arthroscopy-a-5-year-retrospective-study
#18
R H Hossameldin, J P McCain
Temporomandibular joint (TMJ) arthroscopy is a minimally invasive surgical approach for intra-articular TMJ diseases. Office-based arthroscopy using the smallest TMJ scope allows for good visualization, as well as the ability to lavage the joint in an office setting. This study aimed to assess the efficacy of an office-based TMJ arthroscopic technique. A retrospective evaluation of 363 patients with a TMJ disorder was performed. These patients underwent office-based arthroscopy using the OnPoint 1.2mm Scope System (Biomet Microfixation, Jacksonville, FL, USA) in Florida, USA, from July 2007...
July 24, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28750856/readability-of-patient-education-materials-from-the-web-sites-of-orthopedic-implant-manufacturers
#19
Meghan M Yi, Paul H Yi, Khalil I Hussein, Michael B Cross, Craig J Della Valle
BACKGROUND: Prior studies indicate that orthopedic patient education materials are written at a level that is too high for the average patient. The purpose of this study was to assess the readability of online patient education materials provided by orthopedic implant manufacturers. METHODS: All patient education articles available in 2013 from the web sites of the 5 largest orthopedic implant manufacturers were identified. Each article was evaluated with the Flesch-Kincaid (FK) readability test...
July 11, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28726133/iron-protects-porcine-plasma-coagulation-kinetics-from-degradation-by-crotalus-atrox-venom
#20
Christine S Olver, Vance G Nielsen
While the administration of antivenom to treat hemotoxic snake bite injury remains the gold standard of therapy, we have demonstrated that modifying human fibrinogen with iron and carbon monoxide renders it resistant to fibrinogenolytic snake venom enzymes. In order to translate these findings into a possible biometal-based therapy complementary to antivenom administration, a preclinical model that possesses fibrinogen that closely mimics the human molecule in response to iron and carbon monoxide needed to be identified...
July 19, 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
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