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Cerebral malaria

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https://www.readbyqxmd.com/read/29747626/differential-plasma-microvesicle-and-brain-profiles-of-microrna-in-experimental-cerebral-malaria
#1
Amy Cohen, Anna Zinger, Natalia Tiberti, Georges E R Grau, Valery Combes
BACKGROUND: Cerebral malaria (CM) is a fatal complication of Plasmodium infection, mostly affecting children under the age of five in the sub-Saharan African region. CM pathogenesis remains incompletely understood, although sequestered infected red blood cells, inflammatory cells aggregating in the cerebral blood vessels, and the microvesicles (MV) that they release in the circulation, have been implicated. Plasma MV numbers increase in CM patients and in the murine model, where blocking their release, genetically or pharmacologically, protects against brain pathology, suggesting a role of MV in CM neuropathogenesis...
May 11, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29746467/disentangling-complex-parasite-interactions-protection-against-cerebral-malaria-by-one-helminth-species-is-jeopardized-by-co-infection-with-another
#2
Jessica L Abbate, Vanessa O Ezenwa, Jean-François Guégan, Marc Choisy, Mathieu Nacher, Benjamin Roche
Multi-species interactions can often have non-intuitive consequences. However, the study of parasite interactions has rarely gone beyond the effects of pairwise combinations of species, and the outcomes of multi-parasite interactions are poorly understood. We investigated the effects of co-infection by four gastrointestinal helminth species on the development of cerebral malaria among Plasmodium falciparum-infected patients. We characterized associations among the helminth parasite infra-community, and then tested for independent (direct) and co-infection dependent (indirect) effects of helminths on cerebral malaria risk...
May 10, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29716542/in-depth-comparative-analysis-of-malaria-parasite-genomes-reveals-protein-coding-genes-linked-to-human-disease-in-plasmodium-falciparum-genome
#3
Xuewu Liu, Yuanyuan Wang, Jiao Liang, Luojun Wang, Na Qin, Ya Zhao, Gang Zhao
BACKGROUND: Plasmodium falciparum is the most virulent malaria parasite capable of parasitizing human erythrocytes. The identification of genes related to this capability can enhance our understanding of the molecular mechanisms underlying human malaria and lead to the development of new therapeutic strategies for malaria control. With the availability of several malaria parasite genome sequences, performing computational analysis is now a practical strategy to identify genes contributing to this disease...
May 2, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29695240/convalescent-plasmodium-falciparum-specific-seroreactivity-does-not-correlate-with-paediatric-malaria-severity-or-plasmodium-antigen-exposure
#4
Anne Kessler, Joseph J Campo, Visopo Harawa, Wilson L Mandala, Stephen J Rogerson, Wenzhu B Mowrey, Karl B Seydel, Kami Kim
BACKGROUND: Antibody immunity is thought to be essential to prevent severe Plasmodium falciparum infection, but the exact correlates of protection are unknown. Over time, children in endemic areas acquire non-sterile immunity to malaria that correlates with development of antibodies to merozoite invasion proteins and parasite proteins expressed on the surface of infected erythrocytes. RESULTS: A 1000 feature P. falciparum 3D7 protein microarray was used to compare P...
April 25, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29694418/correction-sequence-variation-in-plasmodium-falciparum-merozoite-surface-protein-2-is-associated-with-virulence-causing-severe-and-cerebral-malaria
#5
Suwanna Chaorattanakawee, Pornlada Nuchnoi, Hathairad Hananantachai, Uranan Tumkosit, David Saunders, Izumi Naka, Jun Ohashi, Jintana Patarapotikul
[This corrects the article DOI: 10.1371/journal.pone.0190418.].
2018: PloS One
https://www.readbyqxmd.com/read/29692971/seizure-freedom-following-surgery-for-multi-focal-epilepsy-due-to-cerebral-malaria
#6
Peraya Piromruen, Chusak Limotai
No abstract text is available yet for this article.
2018: Epilepsy & Behavior Case Reports
https://www.readbyqxmd.com/read/29690995/two-complement-receptor-one-alleles-have-opposing-associations-with-cerebral-malaria-and-interact-with-%C3%AE-thalassaemia
#7
D Herbert Opi, Olivia Swann, Alexander Macharia, Sophie Uyoga, Gavin Band, Carolyne M Ndila, Ewen Harrison, Mahamadou A Thera, Abdoulaye K Kone, Dapa A Diallo, Ogobara K Doumbo, Kirsten E Lyke, Christopher Plowe, Joann M Moulds, Mohammed Shebbe, Neema Mturi, Norbert Peshu, Kathryn Maitland, Ahmed Raza, Dominic P Kwiatkowski, Kirk A Rockett, Thomas Williams, J Alexandra Rowe
Malaria has been a major driving force in the evolution of the human genome. In sub-Saharan African populations, two neighbouring polymorphisms in the Complement Receptor One ( CR1 ) gene, named Sl2 and McCb , occur at high frequencies, consistent with selection by malaria. Previous studies have been inconclusive. Using a large case-control study of severe malaria in Kenyan children and statistical models adjusted for confounders, we estimate the relationship between Sl2 and McCb and malaria phenotypes, and find they have opposing associations...
April 25, 2018: ELife
https://www.readbyqxmd.com/read/29674705/children-with-cerebral-malaria-or-severe-malarial-anaemia-lack-immunity-to-distinct-variant-surface-antigen-subsets
#8
Mark A Travassos, Amadou Niangaly, Jason A Bailey, Amed Ouattara, Drissa Coulibaly, Kirsten E Lyke, Matthew B Laurens, Jozelyn Pablo, Algis Jasinskas, Rie Nakajima, Andrea A Berry, Matthew Adams, Christopher G Jacob, Andrew Pike, Shannon Takala-Harrison, Li Liang, Bourema Kouriba, Abdoulaye K Kone, J Alexandra Rowe, JoAnn Moulds, Dapa A Diallo, Ogobara K Doumbo, Mahamadou A Thera, Philip L Felgner, Christopher V Plowe
Variant surface antigens (VSAs) play a critical role in severe malaria pathogenesis. Defining gaps, or "lacunae", in immunity to these Plasmodium falciparum antigens in children with severe malaria would improve our understanding of vulnerability to severe malaria and how protective immunity develops. Using a protein microarray with 179 antigen variants from three VSA families as well as more than 300 variants of three other blood stage P. falciparum antigens, reactivity was measured in sera from Malian children with cerebral malaria or severe malarial anaemia and age-matched controls...
April 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29669942/cxcl10-stabilizes-t-cell-brain-endothelial-cell-adhesion-leading-to-the-induction-of-cerebral-malaria
#9
Elizabeth W Sorensen, Jeffrey Lian, Aleksandra J Ozga, Yoshishige Miyabe, Sophina W Ji, Shannon K Bromley, Thorsten R Mempel, Andrew D Luster
Malaria remains one of the world's most significant human infectious diseases and cerebral malaria (CM) is its most deadly complication. CM pathogenesis remains incompletely understood, hindering the development of therapeutics to prevent this lethal complication. Elevated levels of the chemokine CXCL10 are a biomarker for CM, and CXCL10 and its receptor CXCR3 are required for experimental CM (ECM) in mice, but their role has remained unclear. Using multiphoton intravital microscopy, CXCR3 receptor- and ligand-deficient mice and bone marrow chimeric mice, we demonstrate a key role for endothelial cell-produced CXCL10 in inducing the firm adhesion of T cells and preventing their cell detachment from the brain vasculature...
April 19, 2018: JCI Insight
https://www.readbyqxmd.com/read/29625893/interleukin-15-complex-treatment-protects-mice-from-cerebral-malaria-by-inducing-interleukin-10-producing-natural-killer-cells
#10
Kristina S Burrack, Matthew A Huggins, Emily Taras, Philip Dougherty, Christine M Henzler, Rendong Yang, Sarah Alter, Emily K Jeng, Hing C Wong, Martin Felices, Frank Cichocki, Jeffrey S Miller, Geoffrey T Hart, Aaron J Johnson, Stephen C Jameson, Sara E Hamilton
Cerebral malaria is a deadly complication of Plasmodium infection and involves blood brain barrier (BBB) disruption following infiltration of white blood cells. During experimental cerebral malaria (ECM), mice inoculated with Plasmodium berghei ANKA-infected red blood cells develop a fatal CM-like disease caused by CD8+ T cell-mediated pathology. We found that treatment with interleukin-15 complex (IL-15C) prevented ECM, whereas IL-2C treatment had no effect. IL-15C-expanded natural killer (NK) cells were necessary and sufficient for protection against ECM...
March 20, 2018: Immunity
https://www.readbyqxmd.com/read/29598889/severe-malaria-presenting-to-the-emergency-department-a-collaborative-approach-utilizing-exchange-transfusion-and-artesunate
#11
David Zodda, Gabrielle Procopio, Kevin Hewitt, Andrew Parrish, Bindu Balani, Joseph Feldman
We describe the case of a previously healthy 33year-old male pilot recently arrived to the United States from Africa. The patient presented to our ED febrile and disoriented, with projectile coffee-ground emesis. He was later found to have severe malaria and cerebral parasitemia. Due to the severity of his illness, the patient received the anti-malarial medication Artesunate as well as several exchange transfusions. Within 48h his parasitic load was reduced from 42% to 0.4%. The following is an account of a collaborative effort that spans the specialties of emergency medicine, infectious disease, and critical care medicine...
March 14, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29578406/neurovascular-sequestration-in-paediatric-p-falciparum-malaria-is-visible-clinically-in-the-retina
#12
Valentina Barrera, Ian Jc MacCormick, Gabriela Czanner, Paul Stephenson Hiscott, Valerie Ann White, Alister G Craig, Nicholas Alexander Venton Beare, Lucy Hazel Culshaw, Yalin Zheng, Simon Charles Biddolph, Danny A Milner, Steve Kamiza, Malcolm E Molyneux, Terrie E Taylor, Simon Peter Harding
Retinal vessel changes and retinal whitening, distinctive features of malarial retinopathy, can be directly observed during routine eye examination in children with P.falciparum cerebral malaria. We investigated their clinical significance and underlying mechanisms through linked clinical, clinicopathological and image analysis studies. Orange vessels and severe foveal whitening (clinical examination, n=817, OR, 95% CI: 2.90, 1.96-4.30; 3.4, 1.8-6.3, both p<0.001), and arteriolar involvement by intravascular filling defects (angiographic image analysis, n=260, 2...
March 26, 2018: ELife
https://www.readbyqxmd.com/read/29576904/noninvasive-measures-of-brain-edema-predict-outcome-in-pediatric-cerebral-malaria
#13
Samuel D Kampondeni, Gretchen L Birbeck, Karl B Seydel, Nicholas A Beare, Simon J Glover, Colleen A Hammond, Cowles A Chilingulo, Terrie E Taylor, Michael J Potchen
Background: Increased brain volume (BV) and subsequent herniation are strongly associated with death in pediatric cerebral malaria (PCM), a leading killer of children in developing countries. Accurate noninvasive measures of BV are needed for optimal clinical trial design. Our objectives were to examine the performance of six different magnetic resonance imaging (MRI) BV quantification measures for predicting mortality in PCM and to review the advantages and disadvantages of each method...
2018: Surgical Neurology International
https://www.readbyqxmd.com/read/29576450/common-piezo1-allele-in-african-populations-causes-rbc-dehydration-and-attenuates-plasmodium-infection
#14
Shang Ma, Stuart Cahalan, Gregory LaMonte, Nathan D Grubaugh, Weizheng Zeng, Swetha E Murthy, Emma Paytas, Ramya Gamini, Viktor Lukacs, Tess Whitwam, Meaghan Loud, Rakhee Lohia, Laurence Berry, Shahid M Khan, Chris J Janse, Michael Bandell, Christian Schmedt, Kai Wengelnik, Andrew I Su, Eric Honore, Elizabeth A Winzeler, Kristian G Andersen, Ardem Patapoutian
Hereditary xerocytosis is thought to be a rare genetic condition characterized by red blood cell (RBC) dehydration with mild hemolysis. RBC dehydration is linked to reduced Plasmodium infection in vitro; however, the role of RBC dehydration in protection against malaria in vivo is unknown. Most cases of hereditary xerocytosis are associated with gain-of-function mutations in PIEZO1, a mechanically activated ion channel. We engineered a mouse model of hereditary xerocytosis and show that Plasmodium infection fails to cause experimental cerebral malaria in these mice due to the action of Piezo1 in RBCs and in T cells...
March 8, 2018: Cell
https://www.readbyqxmd.com/read/29570016/early-and-middle-childhood-developmental-cognitive-and-psychiatric-outcomes-of-malawian-children-affected-by-retinopathy-positive-cerebral-malaria
#15
Michael J Boivin, Arpita Mohanty, Alla Sikorskii, Maclean Vokhiwa, Jed G Magen, Melissa Gladstone
The objective is to determine the short -and long-term developmental, cognitive, and psychiatric effects of retinopathy positive cerebral malaria (CM-R) among young children in a prospective study assessing them around the onset of disease and again 2 years at preschool and again at school age. In total, 109 children were recruited from the Queen Elizabeth Central Hospital in Blantyre, Malawi, (N = 49) with CM-R and non-malaria controls  (N = 60). Children were assessed for overall motor, language, and social skills using the Malawi Developmental Assessment Tool (MDAT) at preschool age...
March 23, 2018: Child Neuropsychology: a Journal on Normal and Abnormal Development in Childhood and Adolescence
https://www.readbyqxmd.com/read/29566695/cerebrospinal-fluid-plasmodium-falciparum-histidine-rich-protein-2-in-pediatric-cerebral-malaria
#16
Kiran T Thakur, Jimmy Vareta, Kathryn A Carson, Samuel Kampondeni, Michael J Potchen, Gretchen L Birbeck, Ian MacCormick, Terrie Taylor, David J Sullivan, Karl B Seydel
BACKGROUND: Cerebral malaria (CM) causes a rapidly developing coma, and remains a major contributor to morbidity and mortality in malaria-endemic regions. This study sought to determine the relationship between cerebrospinal fluid (CSF) Plasmodium falciparum histidine rich protein-2 (PfHRP-2) and clinical, laboratory and radiographic features in a cohort of children with retinopathy-positive CM. METHODS: Patients included in the study were admitted (2009-2013) to the Pediatric Research Ward (Queen Elizabeth Central Hospital, Blantyre, Malawi) meeting World Health Organization criteria for CM with findings of malarial retinopathy...
March 23, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29558201/inhibition-of-hypoxia-associated-response-and-kynurenine-production-in-response-to-hyperbaric-oxygen-as-mechanisms-involved-in-protection-against-experimental-cerebral-malaria
#17
Marcele F Bastos, Ana Carolina A V Kayano, João Luiz Silva-Filho, João Conrado K Dos-Santos, Carla Judice, Yara C Blanco, Nathaniel Shryock, Michelle K Sercundes, Luana S Ortolan, Carolina Francelin, Juliana A Leite, Rafaella Oliveira, Rosa M Elias, Niels O S Câmara, Stefanie C P Lopes, Letusa Albrecht, Alessandro S Farias, Cristina P Vicente, Claudio C Werneck, Selma Giorgio, Liana Verinaud, Sabrina Epiphanio, Claudio R F Marinho, Pritesh Lalwani, Rogerio Amino, Julio Aliberti, Fabio T M Costa
Cerebral malaria (CM) is a multifactorial syndrome involving an exacerbated proinflammatory status, endothelial cell activation, coagulopathy, hypoxia, and accumulation of leukocytes and parasites in the brain microvasculature. Despite significant improvements in malaria control, 15% of mortality is still observed in CM cases, and 25% of survivors develop neurologic sequelae for life-even after appropriate antimalarial therapy. A treatment that ameliorates CM clinical signs, resulting in complete healing, is urgently needed...
March 20, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29554958/long-term-effect-of-uncomplicated-plasmodium-berghei-anka-malaria-on-memory-and-anxiety-like-behaviour-in-c57bl-6-mice
#18
Luciana Pereira de Sousa, Roberto Farina de Almeida, Flávia Lima Ribeiro-Gomes, Leonardo José de Moura Carvalho, Tadeu Mello E Souza, Diogo Onofre Gomes de Souza, Cláudio Tadeu Daniel-Ribeiro
BACKGROUND: Cerebral malaria, the main complication of Plasmodium falciparum infection in humans, is associated with persistent neurocognitive sequels both in human disease and the murine experimental model. In recent years, cognitive deficits related to uncomplicated (non-cerebral) malaria have also been reported in chronically exposed residents of endemic areas, but not in some murine experimental models of non-cerebral malaria. This study aimed at evaluating the influence of uncomplicated malaria on different behavioural paradigms associated with memory and anxiety-like parameters in a murine model that has the ability to develop cerebral malaria...
March 20, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29547190/-dancing-eye-dancing-feet-in-cerebral-malaria-a-rare-association
#19
Dharmesh Bhalodiya, Chaturbhuj Rathore, Varun Gupta, Sanjay Prakash, Kamal Pathak
No abstract text is available yet for this article.
March 2018: Neurology India
https://www.readbyqxmd.com/read/29512760/artesunate-suppresses-oxidative-and-inflammatory-processes-by-activating-nrf2-and-ros%C3%A2-dependent-p38-mapk-and-protects-against-cerebral-ischemia%C3%A2-reperfusion-injury
#20
Hui Lu, Bincheng Wang, Ningning Cui, Yanchun Zhang
Artesunate is a semi-synthetic derivative of artemisinin that is used in the treatment of patients with malaria. Artesunate has also been reported to exert immune‑regulatory, antitumor, hepatoprotective, anti‑inflammatory and smooth muscle relaxing functions. The present study aimed to investigate the putative protective effects of artesunate against cerebral ischemia/reperfusion injury (CIRI), and to elucidate the molecular mechanisms underlying its effects. A CIRI mouse model was created via middle cerebral artery occlusion for 2 h, followed by 22 h of reperfusion...
May 2018: Molecular Medicine Reports
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