keyword
https://read.qxmd.com/read/38536458/scabies-in-infants-and-children-a-narrative-review
#1
REVIEW
Anca E Chiriac, Adriana Diaconeasa, Raluca Miulescu, Uwe Wollina
Scabies is a human ectoparasitosis caused by Sarcoptes scabei var. hominis. World-wide around 300 million patients are affected. Infants and children have the highest incidence rates. Poverty and overcrowding are social factors contributing to a higher risk of transmission and treatment failure. The leading symptom of the infestation is itch. Complications are bacterial infections that are responsible for mortality. Diagnosis is clinical. Non-invasive imaging technologies like dermoscopy can be used. Polymerase chain reaction (PCR) is less sensitive and specific than microscopy of skin scrapings...
March 27, 2024: European Journal of Pediatrics
https://read.qxmd.com/read/38536004/psychometric-properties-of-the-pans-31-item-symptom-rating-scale
#2
JOURNAL ARTICLE
Gail A Bernstein, Maroof H Khan, Rebecca L Freese, Cindy Manko, Melissa Silverman, Sana Ahmed, Bahare Farhadian, Meiqian Ma, Margo Thienemann, Tanya K Murphy, Jennifer Frankovich
Objectives: Pediatric acute-onset neuropsychiatric syndrome (PANS) is characterized by sudden onset of obsessive-compulsive disorder and/or eating restriction with associated neuropsychiatric symptoms from at least two of seven categories. The PANS 31-Item Symptom Rating Scale (PANS Rating Scale) was developed to identify and measure the severity of PANS symptoms. The objective of this study was to define the psychometric properties of the PANS Rating Scale. Methods: Children with PANS ( N  = 135) and their parents participated...
March 27, 2024: Journal of Child and Adolescent Psychopharmacology
https://read.qxmd.com/read/38535867/phytotherapeutic-approaches-in-canine-pediatrics
#3
REVIEW
Fausto Quintavalla
Phytotherapy is a clinical modality that incorporates botanical remedies as part of the therapeutic approach. It is a very ancient branch of medicine that is currently undergoing a renaissance, evident in the numerous preparations available on the market. The majority of these formulations are for preventive and curative use in adult animals. Experimental experiences in the pediatric age group are particularly scarce within the existing literature. Since these products are readily accessible, dog owners often turn to them due to their ease of availability, a preference for self-medication, and the perception that herbs are safer, gentler, and less expensive than conventional medications, often leading them to bypass seeking the advice of experienced professionals...
March 20, 2024: Veterinary Sciences
https://read.qxmd.com/read/38535510/clinical-characteristics-of-118-pediatric-patients-with-acute-benign-myositis-associated-with-influenza-a-virus-infection
#4
JOURNAL ARTICLE
Shaoqun Jiang, Jieling Li, Jie Cao, Yuexu Ou, Yuanhui Duan, Xiaoming Gan
OBJECTIVE: The objective of this study was to investigate the clinical and laboratory features of acute benign myositis associated with influenza A virus infection in children. METHODS: A retrospective analysis was performed on the clinical data of 118 children with acute benign myositis associated with influenza A virus infection who were admitted to the Children's Hospital of Chongqing Medical University during the epidemic period of influenza A from February 2023 to May 2023...
March 27, 2024: Pediatric Infectious Disease Journal
https://read.qxmd.com/read/38535043/determination-of-l-asparaginase-activity-and-its-therapeutic-monitoring-in-children-with-hematological-malignancies-in-a-single-croatian-center
#5
JOURNAL ARTICLE
Jasna Lenicek Krleza, Ana Katusic Bojanac, Gordana Jakovljevic
BACKGROUND: Among malignant diseases which develop during childhood, hematological cancers, such as leukemias and lymphomas, are the most common. Outcomes have greatly improved due to the refinement of multiagent chemotherapy regimens that include enhanced asparaginase therapy. In this study, we aimed to evaluate our experiences related to the analytical and clinical significance of determining l-Asparaginase activity. METHODS: Since 2016, the Laboratory of the Children's Hospital Zagreb has routinely measured l-Asparaginase activity and to date, has measured more than 280 examples of activity in a total of 57 children with hematological malignancy treated at the Pediatric Oncology Department of the Children's Hospital Zagreb...
March 15, 2024: Diagnostics
https://read.qxmd.com/read/38534941/cell-therapy-transplant-canada-cttc-consensus-based-guideline-2024-for-management-and-treatment-of-chronic-graft-versus-host-disease-and-future-directions-for-development
#6
Dennis Dong Hwan Kim, Gizelle Popradi, Kylie Lepic, Kristjan Paulson, David Allan, Ram Vasudevan Nampoothiri, Sylvie Lachance, Uday Deotare, Jennifer White, Mohamed Elemary, Kareem Jamani, Christina Fraga, Christopher Lemieux, Igor Novitzky-Basso, Arjun Datt Law, Rajat Kumar, Irwin Walker, Kirk R Schultz
This is a consensus-based Canadian guideline whose primary purpose is to standardize and facilitate the management of chronic graft-versus-host disease (cGvHD) across the country. Creating uniform healthcare guidance in Canada is a challenge for a number of reasons including the differences in healthcare authority structure, funding and access to healthcare resources between provinces and territories, as well as the geographic size. These differences can lead to variable and unequal access to effective therapies for GvHD...
March 8, 2024: Current Oncology
https://read.qxmd.com/read/38533999/vancomycin-auc-0-24-estimation-using-first-order-pharmacokinetic-methods-in-pediatric-patients
#7
JOURNAL ARTICLE
Hope H Brandon, David S Burgess, Katie L Wallace, Elizabeth B Autry, Katie B Olney
INTRODUCTION: The optimal dosing and monitoring of vancomycin in pediatrics is still unknown but has evolved to emphasize area under the curve over 24 h (AUC0-24 ) over minimum concentration (Cmin ) monitoring. Real-world data supporting the feasibility of two-concentration kinetics with first-order equations for the estimation of vancomycin AUC0-24 in pediatric patients are lacking. OBJECTIVES: To describe the interplay of vancomycin dose, AUC0-24 , and Cmin using first-order equations within four pediatric age groups...
March 27, 2024: Pharmacotherapy
https://read.qxmd.com/read/38533429/harmonising-iv-oxycodone-with-paediatric-perioperative-medications-a-compatibility-study-through-y-type-connectors
#8
JOURNAL ARTICLE
Souha H Youssef, Alka Garg, Yunmei Song, Nicole E Wylie, Sanjay Garg
PURPOSE: Co-administering multiple intravenous (IV) agents via Y-connectors is a common practice in hospitalised and fasting surgical patients. However, there is a lack of reliable data confirming the physical compatibility of some combinations including IV oxycodone, a drug that is gaining increasing popularity in the perioperative period. Concern regarding physical drug incompatibilities precludes concurrent coadministration with other common drugs through a single lumen. This can result in the cessation of infusions to allow the administration of other medications, resulting in exacerbation of acute pain...
2024: Drug Design, Development and Therapy
https://read.qxmd.com/read/38533170/keto-clarity-a-comprehensive-systematic-review-exploring-the-efficacy-safety-and-mechanisms-of-ketogenic-diet-in-pediatric-epilepsy
#9
REVIEW
Youmna Faheem, Amisha Jaiswal, Kainaat Shergill, Kusalik Boppana, Naiela E Almansouri, Saloni Bakkannavar, Ann Kashmer Yu
Epilepsy, a widespread neurological disorder characterized by recurrent seizures, affects millions globally, with a significant impact on the pediatric population. Antiepileptic drugs (AEDs) constitute the primary treatment; however, drug-resistant epilepsy (DRE), especially in children, poses a therapeutic challenge. Alternative interventions, such as surgery, vagus nerve stimulation, and the ketogenic diet (KD), have been explored. This systematic review aims to investigate various types of KDs, their distinctions, their effectiveness, and their safety concerning the reduction of seizure frequency, achieving seizure freedom, and the occurrence of adverse events...
February 2024: Curēus
https://read.qxmd.com/read/38533143/propofol-sedation-in-pediatric-upper-endoscopy-a-study-of-pharmacodynamics-and-the-effects-of-gastroenterologists-anesthesiologists-and-supervised-participants-on-the-procedure-time-and-sedation-time
#10
JOURNAL ARTICLE
Ahila Manivannan, Shailender Madani, Michael Woodall, George McKelvey, Sharon Kemper
Background and aims Propofol combined with fentanyl is a commonly used sedative for pediatric upper endoscopies (UEs). The primary aim was to study the association between propofol dose and procedure and sedation time. The secondary aims were to assess the pharmacodynamics of propofol use with fentanyl and evaluate if gastroenterologists' and anesthesiologists' years of experience or the presence of supervised participants (such as students, residents, and fellows) have any influence on the procedure and sedation time...
February 2024: Curēus
https://read.qxmd.com/read/38531754/detection-and-reduction-of-errors-in-parenteral-nutrition-compounding-through-gravimetric-and-product-control
#11
JOURNAL ARTICLE
Daniel Gómez-Costas, Rosa María Romero-Jiménez, Maria Elena Lobato-Matilla, Raquel Culebras, Judy Alejandra González, Sergio Herrero-Bermejo, Ana María Herranz-Alonso, María Sanjurjo
OBJECTIVE: To analyze the errors in the preparation of parenteral nutrition in a Pharmacy Service, detected through an already consolidated gravimetric and product quality control, and compare them with those detected during the initial years of implementing this quality control. METHODS: All errors detected through quality control in the compounding of pediatric and adult parenteral nutrition between 2019 and 2021 were prospectively analyzed. This quality control consisted of 3 sequential processes: a visual check, a gravimetric control, and a product control...
March 25, 2024: Farmacia Hospitalaria
https://read.qxmd.com/read/38531618/high-sensitive-troponint-interleukin-8-and-interleukin-6-link-with-post-surgery-risk-in-infant-heart-surgery
#12
JOURNAL ARTICLE
Elin M Thorlacius, Juho Keski-Nisula, Maria Vistnes, Tiina Ojala, Mattias Molin, Mats Synnergren, Birgitta S Romlin, Sven-Erik Ricksten, Håkan Wåhlander, Albert Gyllencreutz Castellheim
BACKGROUND: This study focuses on biomarkers in infants after open heart surgery, and examines the association of high-sensitive troponin T (hs-cTnT), interleukin-6 (IL-6), and interleukin-8 (IL-8) with postoperative acute kidney injury (AKI), ventilatory support time and need of vasoactive drugs. METHODS: Secondary exploratory study from a double-blinded clinical randomized trial (Mile-1) on 70 infants undergoing open heart surgery with cardiopulmonary bypass (CPB)...
March 26, 2024: Acta Anaesthesiologica Scandinavica
https://read.qxmd.com/read/38530681/trends-in-substance-related-visits-among-youth-to-us-children-s-hospitals-2016-2021-an-analysis-of-the-pediatric-health-information-system-database
#13
JOURNAL ARTICLE
Alexis Ball, Scott Hadland, Jonathan Rodean, Matt Hall, Jason Mendoza, Kym Ahrens
PURPOSE: This study evaluates recent trends in substance-related visits among youth visiting children's hospitals. METHODS: We conducted a cross-sectional study of substance-related visits to pediatric hospitals within the Pediatric Health Information System database of youth aged 12-21 years from 2016 through 2021. Substance-related visits were defined as acute visits for International Classification of Diseases, 10th Revision Clinical Modification codes related to substance 'use', dependence, or overdoses for alcohol, cannabis, nicotine, opioids, sedatives, stimulants, hallucinogens, or other substances...
March 25, 2024: Journal of Adolescent Health
https://read.qxmd.com/read/38529664/strategies-for-co-2-laser-use-in-laryngeal-microsurgery-a-systematic-review
#14
REVIEW
Vivianne Landry, Ève Sedillot-Daniel, Tareck Ayad, Andrée-Anne Leclerc
OBJECTIVE: We aim to systematically review the literature addressing perioperative practices for optimal use of the CO2 laser in laryngeal transoral laser microsurgery (TOLMS), with a focus on safety. DATA SOURCES: A systematic review of publications indexed in Medline, Embase, and EBM reviews-Cochrane Central Register of Controlled Trials which evaluated perioperative strategies for the use of CO2 laser in laryngeal TOLMS was conducted. REVIEW METHODS: Records obtained from the search strategy were assessed for eligibility in a 2-step process by 2 independent researchers using the Covidence software...
March 26, 2024: Otolaryngology—Head and Neck Surgery
https://read.qxmd.com/read/38529652/diagnostic-strategy-for-suspected-unilateral-absence-of-the-pulmonary-artery
#15
JOURNAL ARTICLE
Van Luong Hoang, Viet Anh Lam, Thanh Nguyen Pham
UNLABELLED: <p>Background: Unilateral absence of the pulmonary artery (UAPA) is a very rare congenital anomaly. OBJECTIVE: To analyze the diagnostic strategy applied to seven patients with UAPA who were examined and subsequently treated at the National Lung Hospital, Hanoi, Vietnam. METHODS: All seven patients, including three pediatric cases (1, 2, and 14 years old) and four adult cases (21, 26, 44, and 53 years old), had a history of recurrent pneumonia, and the clinical symptoms on admission included cough, progressive dyspnea, chest pain, and fatigue...
March 19, 2024: Current medical imaging
https://read.qxmd.com/read/38528568/an-epidemiological-investigation-of-high-risk-infants-for-respiratory-syncytial-virus-infections-a-retrospective-cohort-study
#16
JOURNAL ARTICLE
Michela Servadio, Marco Finocchietti, Chiara Vassallo, Riccardo Cipelli, Franca Heiman, Giulia Di Lucchio, Bianca Oresta, Antonio Addis, Valeria Belleudi
BACKGROUND: Respiratory Syncytial Virus (RSV) infections may lead to severe consequences in infants born preterm with breathing problems (such as bronchopulmonary dysplasia (BPD) and respiratory distress syndrome (RDS)) or congenital heart diseases (CHD). Since studies investigating the influence of different gestational age (WGA) and concomitant specific comorbidities on the burden of RSV infections are scarce, the present study aimed to better characterize these high-risk populations in the Italian context...
March 25, 2024: Italian Journal of Pediatrics
https://read.qxmd.com/read/38528509/clinical-analysis-of-acute-poisoning-in-children
#17
JOURNAL ARTICLE
Huajun Zhang, Qin Huo, Rui Jing, Meng Dong
OBJECTIVE: The clinical characteristics of hospitalized children with acute poisoning were analyzed to provide a reference for preventing poisoning and seeking effective prevention and treatment. METHODS: The clinical data of 112 children with acute poisoning admitted to Qilu Hospital of Shandong University from January 1, 2018, to December 31, 2021, were collected and analyzed from different perspectives. RESULTS: The majority of acute poisoning cases that occurred in children were in early childhood and preschool age (89 cases, accounting for 79...
March 25, 2024: BMC Pediatrics
https://read.qxmd.com/read/38527733/patient-perceived-understanding-of-home-going-medication-with-transitions-of-care-services-at-a-pediatric-institution
#18
JOURNAL ARTICLE
Karielle Shaffery, Sonya Sebastian, Hannah Thornton, Mahmoud Abdel-Rasoul
BACKGROUND: Transitions of care (TOC) is the coordination and continuity of healthcare as a patient transfers between different settings.1 This can include a wide range of services, such as medication reconciliation, patient counseling, bedside delivery of medications, and others that meet individual patient needs.2 In the pediatric population, patients are at increased risk of potential medication errors and subsequent harm due to reduced patient and/or caregiver health literacy, limited dosage form availability, and errors in medication administration...
March 23, 2024: Journal of the American Pharmacists Association: JAPhA
https://read.qxmd.com/read/38527508/-diagnosis-and-treatment-of-arrhythmogenic-cardiomyopathy-in-children
#19
JOURNAL ARTICLE
W Q Ye, Y Y Xiao, X K Jiang, M Jin, X F Wang, W W Ding
Objective: To summarize the clinical manifestations, experiences in diagnosis and treatment of arrhythmogenic cardiomyopathy (ACM) in children. Methods: A retrospective analysis of the clinical manifestations, laboratory tests, radiological features, treatment and follow-up results was conducted in 11 children diagnosed with ACM at the center of congenital heart disease, Beijing anzhen hospital from May 2010 to March 2022. Results: A total of 11 patients aged 2 to 16 years, including 5 males and 6 females were diagnosed with ACM...
March 25, 2024: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://read.qxmd.com/read/38527429/the-intersection-of-epigenetic-alterations-and-developmental-state-in-pediatric-ependymomas
#20
REVIEW
Alisha Simone Kardian, Stephen Mack
BACKGROUND: Ependymomas are the third most common brain cancer in children and have no targeted therapies. They are divided into at least 9 major subtypes based on molecular characteristics and major drivers and have few genetic mutations compared to the adult form of this disease, leading to investigation of other mechanisms. SUMMARY: Epigenetic alterations such as transcriptional programs activated by oncofusion proteins and alterations in histone modifications play an important role in development of this disease...
March 25, 2024: Developmental Neuroscience
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