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https://www.readbyqxmd.com/read/29456387/clinico-epidemiological-profile-of-pediatric-rheumatology-disorders-in-eastern-india
#1
Pratap Kumar Patra, Manish Kumar
Background: Data on rheumatological disorders in children from developing countries like India are scarce. Hence, this study aimed to understand the clinical and epidemiological profile of rheumatological disorders in children as this can help organize comprehensive evidence-based health care services. Methodology: A retrospective hospital-based study was designed in pediatric rheumatology clinic of the All India Institute of Medical Sciences, Patna, India, from January 2015 to December 2016...
January 2018: Journal of Natural Science, Biology, and Medicine
https://www.readbyqxmd.com/read/29456086/low-dose-propofol-for-pediatric-migraine-a-prospective-randomized-controlled-trial
#2
David C Sheridan, Matthew L Hansen, Amber L Lin, Rongwei Fu, Garth D Meckler
BACKGROUND: Migraine headaches are a common reason for pediatric emergency department (ED) visits. Small studies suggest the potential efficacy of sub-anesthetic doses of propofol for migraine with a favorable side effect profile and potentially decreased length of stay (LOS). OBJECTIVE: The objective of this study was to compare the efficacy of low-dose propofol (LDP) to standard therapy (ST) in pediatric migraine treatment. METHODS: We conducted a prospective, pragmatic randomized controlled trial from April 2014 through June 2016 in the ED at two pediatric hospitals...
February 15, 2018: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29454255/effects-of-adjunctive-eslicarbazepine-acetate-on-neurocognitive-functioning-in-children-with-refractory-focal-onset-seizures
#3
Sergiusz Jóźwiak, P Veggiotti, J Moreira, H Gama, F Rocha, P Soares-da-Silva
PURPOSE: This was a phase-II, randomized, double-blind (DB), placebo-controlled study aimed to evaluate neurocognitive effects of eslicarbazepine acetate (ESL) as adjunctive therapy in pediatric patients with refractory focal-onset seizures (FOS). METHODS: Children (6-16years old) with FOS were randomized (2:1) to ESL or placebo. Treatment started at 10mg/kg/day, was up-titrated up to 30mg/kg/day (target dose), and maintained for 8weeks, followed by one-year open-label follow-up...
February 13, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29453599/sequential-analysis-in-neonatal-research-systematic-review
#4
Sebastiano A G Lava, Valéry Elie, Phuong Thi Viet Ha, Evelyne Jacqz-Aigrain
As more new drugs are discovered, traditional designs come at their limits. Ten years after the adoption of the European Paediatric Regulation, we performed a systematic review on the US National Library of Medicine and Excerpta Medica database of sequential trials involving newborns. Out of 326 identified scientific reports, 21 trials were included. They enrolled 2832 patients, of whom 2099 were analyzed: the median number of neonates included per trial was 48 (IQR 22-87), median gestational age was 28.7 (IQR 27...
February 16, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29452306/boundaries-between-familial-mediterranean-fever-and-juvenile-spondyloarthritis-analysis-of-three-french-retrospective-cohorts
#5
Bilade Cherqaoui, Linda Rossi-Semerano, Sophie Georgin-Lavialle, Perrine Dusser, Caroline Galeotti, Maryam Piram, Véronique Hentgen, Isabelle Touitou, Isabelle Koné-Paut
OBJECTIVES: Children with Familial Mediterranean fever may suffer from musculoskeletal involvement, somewhat difficult to distinguish from juvenile spondyloarthritis. The association of these two diseases has been scarcely reported in children. Objectives of this work were to define the association of familial Mediterranean fever and juvenile spondyloarthritis in France. METHODS: Three cohorts of children with familial Mediterranean fever, juvenile spondyloarthritis, familial Mediterranean fever related juvenile spondyloarthritis, were retrospectively identified in the French reference center of auto-inflammatory diseases...
February 13, 2018: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/29451420/integration-of-clinical-pharmacists-into-an-ambulatory-pediatric-hematology-oncology-transplant-clinic
#6
Kimberly D Defoe, Jennifer Jupp, Tara Leslie
Objectives To describe key activities performed by a newly deployed clinical pharmacist in an outpatient pediatric hematology, oncology, transplant clinic. To demonstrate how utilization of the pharmacist evolved, as indicated by changes in frequency of key activities, during the first four months of integration. Design Clinical pharmacists were made consistently available in an outpatient clinic serving hematology, oncology, transplant patients and their families. A list of key activities, based on provincial clinical pharmacist standards, was created to provide a framework for the role...
January 1, 2018: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/29449434/msh6-haploinsufficiency-at-relapse-contributes-to-the-development-of-thiopurine-resistance-in-pediatric-b-lymphoblastic-leukemia
#7
Nikki A Evensen, P Pallavi Madhusoodhan, Julia Meyer, Jason Saliba, Ashfiyah Chowdhury, David J Araten, Jacob Nersting, Teena Bhatla, Tiffaney L Vincent, David Teachey, Stephen P Hunger, Jun Yang, Kjeld Schmiegelow, William L Carroll
Survival of children with relapsed acute lymphoblastic leukemia is poor and understanding mechanisms underlying resistance is essential in developing new therapy. Relapse-specific heterozygous deletions in MSH6, a crucial part of DNA Mismatch Repair, are frequently detected. Our aim was to determine whether MSH6 deletion results in a hypermutator phenotype associated with generation of secondary mutations involved in drug resistance or leads to a failure to initiate apoptosis directly in response to chemotherapeutic agents...
February 15, 2018: Haematologica
https://www.readbyqxmd.com/read/29449049/extended-spectrum-%C3%AE-lactamase-producing-enterobacteriaceae-national-study-of-antimicrobial-treatment-for-pediatric-urinary-tract-infection
#8
M Lagree, S Bontemps, R Dessein, F Angoulvant, F Madhi, A Martinot, R Cohen, F Dubos
OBJECTIVE: To evaluate clinical practices for ESBL-producing urinary tract infection (UTI) in France. METHODS: We performed an observational, retrospective, cross-sectional, hospital-based study in 22 pediatric departments of university or secondary care hospitals. We collected data of the last five patients presenting with ESBL-producing UTI in 2012 and the physicians' therapeutic approach to two case vignettes of acute non-septic ESBL-producing pyelonephritis (7-month-old girl) and cystitis (30-month-old girl)...
February 12, 2018: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/29447360/allocation-of-treatment-responsibility-in-adolescents-with-epilepsy-associations-with-cognitive-skills-and-medication-adherence
#9
Christina E Holbein, Aimee W Smith, James Peugh, Avani C Modi
Objectives: To describe allocation of treatment responsibility (ATR) in adolescents with epilepsy, investigate associations between cognitive skills and ATR, and examine whether ATR for antiepileptic drugs (AEDs) predicted electronically monitored adherence. Method: Sixty adolescents with epilepsy and their caregivers completed the Allocation of Treatment Responsibility Scale and a battery of self-report measures. Medical chart review data and electronically monitored AED adherence were collected for 1 year...
February 13, 2018: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/29446988/diagnosing-tongue-base-obstruction-in-pierre-robin-sequence-infants-sleep-vs-awake-endoscopy
#10
Jake J Lee, Matthew D Ford, Allison B Tobey, Noel Jabbour
OBJECTIVE: To investigate whether awake endoscopy can diagnose base-of-tongue obstruction as reliably as sleep endoscopy in infants with Pierre Robin sequence (PRS). DESIGN: The study was retrospective with the clinicians blinded to patient identity. Endoscopy findings were assessed and measured by the performing pediatric otolaryngologist. SETTING: Tertiary care children's hospital. PATIENTS: All infants with PRS managed between January 2005 and July 2015 were included...
January 1, 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29446796/posttraumatic-headache
#11
Raquel Langdon, Sharief Taraman
After sustaining a concussion or mild traumatic brain injury, headaches are one of the most common complaints. The pathophysiologic changes that occur in the setting of injury likely contribute to or cause posttraumatic headaches. Posttraumatic headaches often present as migraine or tension-type headaches. Unlike pain from other types of injuries, headaches following mild traumatic brain injury are more likely to persist. Preexisting conditions such as migraine and mood disorders may influence posttraumatic headache and complicate management...
February 1, 2018: Pediatric Annals
https://www.readbyqxmd.com/read/29446795/management-of-pediatric-migraine-current-therapies
#12
Marina Khrizman, Ann Pakalnis
Migraine is one of the most common neurologic conditions in pediatrics. It can be a significant stressor, causing absences from school and interruption of parents' work and family schedules. The mainstay of treatment remains educating patients about healthy lifestyle practices and the influences of sleep, stressors, and hydration on triggering migraine attacks. Psychological therapies such as biofeedback or cognitive-behavioral therapy may be beneficial in some patients, especially those with prominent psychological comorbidities...
February 1, 2018: Pediatric Annals
https://www.readbyqxmd.com/read/29446447/individualized-prediction-of-seizure-relapse-and-outcomes-following-antiepileptic-drug-withdrawal-after-pediatric-epilepsy-surgery
#13
Herm J Lamberink, Kim Boshuisen, Willem M Otte, Karin Geleijns, Kees P J Braun
The objective of this study was to create a clinically useful tool for individualized prediction of seizure outcomes following antiepileptic drug withdrawal after pediatric epilepsy surgery. We used data from the European retrospective TimeToStop study, which included 766 children from 15 centers, to perform a proportional hazard regression analysis. The 2 outcome measures were seizure recurrence and seizure freedom in the last year of follow-up. Prognostic factors were identified through systematic review of the literature...
February 15, 2018: Epilepsia
https://www.readbyqxmd.com/read/29445162/mycn-drives-glutaminolysis-in-neuroblastoma-and-confers-sensitivity-to-an-ros-augmenting-agent
#14
Tingting Wang, Lingling Liu, Xuyong Chen, Yuqing Shen, Gaojian Lian, Nilay Shah, Andrew M Davidoff, Jun Yang, Ruoning Wang
Heightened aerobic glycolysis and glutaminolysis are characteristic metabolic phenotypes in cancer cells. Neuroblastoma (NBL), a devastating pediatric cancer, is featured by frequent genomic amplification of MYCN, a member of the Myc oncogene family that is primarily expressed in the early stage of embryonic development and required for neural crest development. Here we report that an enriched glutaminolysis gene signature is associated with MYCN amplification in children with NBL. The partial knockdown of MYCN suppresses glutaminolysis in NBL cells...
February 14, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29443401/pediatric-intestinal-failure-associated-liver-disease-challenges-in-identifying-clinically-relevant-biomarkers
#15
Kathleen M Gura, Andrew E Mulberg, Paul D Mitchell, John Yap, Clara Y Kim, Minjun Chen, Alexis Potemkin, Mark Puder
BACKGROUND: Intestinal failure-associated liver disease (IFALD) is complex and diagnosed by concurrent use of parenteral nutrition, clinical presentation, and alterations in hepatic biomarkers exclusive of other causes of liver disease. In comparison with individual measures, composite biomarkers may provide a more effective means for assessing disease progression and response to treatment than single parameters. Since IFALD is considered by some to be a type of drug-induced liver injury (DILI), those diagnostic criteria could potentially be used in this population...
February 2018: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29442293/recombinant-human-ph20-baseline-analysis-of-the-reactive-antibody-prevalence-in-the-general-population-using-healthy-subjects
#16
Sanna Rosengren, Jennifer Souratha, Dave Conway, Douglas B Muchmore, Barry J Sugarman
BACKGROUND: Recombinant human PH20 (rHuPH20) is used to depolymerize hyaluronan in the subcutaneous space, increasing the dispersion and absorption of co-administered drugs. While ~ 5 to 10% of rHuPH20 treatment-naïve healthy volunteers have demonstrated rHuPH20-reactive antibodies, associations with age, sex, fertility, and immune disorders remain unknown. OBJECTIVES: Using demographically diverse healthy volunteers, we assessed the prevalence of rHuPH20-reactive antibodies in the general population and potential associations with fertility and autoimmunity diseases...
February 13, 2018: BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
https://www.readbyqxmd.com/read/29442152/pediatric-contrast-enhanced-ultrasound-in-the-united-states-a-survey-by-the-contrast-enhanced-ultrasound-task-force-of-the-society-for-pediatric-radiology
#17
Susan J Back, Carolina Maya, Kassa Darge, Patricia T Acharya, Carol E Barnewolt, Jamie L Coleman, Jonathan R Dillman, Lynn Ansley Fordham, Misun Hwang, Annie Lim, M Beth McCarville, Marthe M Munden, Harriet J Paltiel, Frank M Volberg
BACKGROUND: The United States Food and Drug Administration (FDA) recently approved an ultrasound (US) contrast agent for intravenous and intravesical administration in children. OBJECTIVE: Survey the usage, interest in and barriers for contrast-enhanced US among pediatric radiologists. MATERIALS AND METHODS: The Contrast-Enhanced Ultrasound Task Force of the Society for Pediatric Radiology (SPR) surveyed the membership of the SPR in January 2017 regarding their current use and opinions about contrast-enhanced US in pediatrics...
February 13, 2018: Pediatric Radiology
https://www.readbyqxmd.com/read/29441456/knowledge-attitude-and-practice-kap-study-of-pediatricians-on-infantile-spasms
#18
Vamsi Krishna Vaddi, Jitendra Kumar Sahu, Sumeet R Dhawan, Renu Suthar, Naveen Sankhyan
OBJECTIVE: To investigate the knowledge, attitude, and practice of Infantile Spasms among pediatricians. METHODS: A survey was carried out among pediatricians serving in Punjab, Haryana, Chandigarh, Himachal Pradesh and Delhi. The survey was done by Survey Monkey Software through emails by using a structured questionnaire between July 2016 and December 2017. RESULTS: A total of 236 pediatricians responded to the survey. Most of the respondents (95...
February 14, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29441439/pediatric-dose-selection-and-utility-of-pbpk-in-determining-dose
#19
Ian E Templeton, Nicholas S Jones, Luna Musib
Interest in determining safe and efficacious doses for drug administration in pediatric patients has increased dramatically in recent years. However, published pediatric clinical studies have failed to increase proportionally with adult clinical study publications. In order to assess the current state of pediatric dose determination and the supporting role of physiologically based pharmacokinetic modeling and simulation in determining pediatric dose, the pediatric clinical literature (2006-2016) and case examples of pediatric PBPK modeling efforts were reviewed...
February 13, 2018: AAPS Journal
https://www.readbyqxmd.com/read/29440007/recommendations-to-enhance-pediatric-cardiovascular-drug-development-report-of-a-multi-stakeholder-think-tank
#20
Rachel D Torok, Jennifer S Li, Prince J Kannankeril, Andrew M Atz, Raafat Bishai, Ellen Bolotin, Stefanie Breitenstein, Cathy Chen, Thomas Diacovo, Timothy Feltes, Patricia Furlong, Michael Hanna, Eric M Graham, Daphne Hsu, D Dunbar Ivy, Dianne Murphy, Lisa A Kammerman, Gregory Kearns, John Lawrence, Brigitte Lebeaut, Danshi Li, Christoph Male, Brian McCrindle, Pierre Mugnier, Jane W Newburger, Gail D Pearson, Vasum Peiris, Lisa Percival, Miriam Pina, Ronald Portman, Robert Shaddy, Norman L Stockbridge, Robert Temple, Kevin D Hill
No abstract text is available yet for this article.
February 10, 2018: Journal of the American Heart Association
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