Sarah D Blaschko, Phitsanu Mahawong, Max Ferretti, Tristan J Cunha, Adriane Sinclair, Hong Wang, Bruce J Schlomer, Gail Risbridger, Laurence S Baskin, Gerald R Cunha
Because both androgens and estrogens have been implicated in penile morphogenesis, we evaluated penile morphology in transgenic mice with known imbalance of androgen and estrogen signaling using scanning electron microscopy (SEM), histology, and immunohistochemistry of androgen and estrogen receptors α/β. Penises of adult wild-type, estrogen receptor-α knockout (αERKO), estrogen receptor-β knockout (βERKO), aromatase knockout (Arom-KO), and aromatase overexpression (Arom+) mice were evaluated, as well as adult mice treated with diethylstilbestrol (DES) from birth to day 10...
July 2013: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology