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Periampullary tumors

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https://www.readbyqxmd.com/read/29761151/endoscopic-ultrasound-guided-choledochoduodenostomy-as-palliative-treatment-a-challenging-case-report
#1
Helena Ribeiro, Richard Azevedo, Ana Caldeira, Rui Sousa, Eduardo Pereira, António Banhudo
We report the case of an 88-year-old female with obstructive jaundice due to a periampullary tumor. The patient developed acute cholangitis and consequent clinical deterioration, so it was decided to perform palliative biliary drainage. Due to duodenal tumor invasion, it was not possible to perform endoscopic retrograde cholangiopancreatography. A different approach was attempted and it was decided to carry out an endoscopic ultrasound-guided choledochoduodenostomy. This procedure was performed with a linear echoendoscope, and using a duodenal bulbar approach, a fistula was created between the bulb and the common bile duct...
April 2018: GE Portuguese Journal of Gastroenterology
https://www.readbyqxmd.com/read/29749333/unexpected-outcome-following-radiofrequency-ablation-of-a-malignant-biliary-stricture
#2
Andrew J Kruger, Somashekar G Krishna
We present a case of a 60-year-old woman with extrahepatic cholangiocarcinoma and recurrent malignant biliary strictures status post placement of two overlapping distal bile duct uncovered self-expandable metal stents (SEMSs) who presented with biliary obstruction due to tumor/tissue ingrowth. She subsequently underwent radiofrequency ablation (RFA) through SEMS to improve biliary stent patency. Post-RFA, thermal injury was observed in the periampullary mucosa. She later developed acute pancreatitis. This is the first case of RFA-induced acute pancreatitis with endoscopic evidence of thermal injury...
March 2018: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/29742772/endoscopic-ultrasound-guided-management-of-bleeding-periampullary-tumor
#3
Malay Sharma, Piyush Somani, Tagore Sunkara, Ritesh Prajapati
No abstract text is available yet for this article.
May 9, 2018: Endoscopy
https://www.readbyqxmd.com/read/29723245/sarcopenia-and-myosteatosis-are-accompanied-by-distinct-biological-profiles-in-patients-with-pancreatic-and-periampullary-adenocarcinomas
#4
Cynthia Stretch, Jean-Michel Aubin, Beata Mickiewicz, Derek Leugner, Tariq Al-Manasra, Elizabeth Tobola, Santiago Salazar, Francis R Sutherland, Chad G Ball, Elijah Dixon, Hans J Vogel, Sambasivario Damaraju, Vickie E Baracos, Oliver F Bathe
INTRODUCTION: Pancreatic and periampullary adenocarcinomas are associated with abnormal body composition visible on CT scans, including low muscle mass (sarcopenia) and low muscle radiodensity due to fat infiltration in muscle (myosteatosis). The biological and clinical correlates to these features are poorly understood. METHODS: Clinical characteristics and outcomes were studied in 123 patients who underwent pancreaticoduodenectomy for pancreatic or non-pancreatic periampullary adenocarcinoma and who had available preoperative CT scans...
2018: PloS One
https://www.readbyqxmd.com/read/29707208/retrospective-cohort-of-pancreatic-and-vater-ampullary-adenocarcinoma-from-a-reference-center-in-mexico
#5
Jorge Sánchez-García, Fernando Candanedo-González, Anna Karen Félix-Félix, Damián Sánchez-Ramírez, Rafael Medrano-Guzmán, Miguel Quintana-Quintana, Yair Benjamín Baas-Cabrera, Eugenia Flores-Figueroa
Introduction: Pancreatic ductal adenocarcinoma (PDAC) and ampulla of Vater adenocarcinomas (AVAC) are periampullary tumors. These tumors have overlapping symptoms and a common treatment, but present differences in their survival and biology. No recent studies in Mexico have been published that describe the clinicopathological characteristics of these tumors. Therefore, the aim of this study was to describe the clinicopathological characteristics of PDAC and AVAC in patients at a reference center in Mexico...
June 2018: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/29702569/diagnostic-accuracy-of-a-64-slice-multi-detector-ct-scan-in-the-preoperative-evaluation-of-periampullary-neoplasms
#6
Shahryar Hashemzadeh, Behzad Mehrafsa, Farzad Kakaei, Reza Javadrashid, Rosa Golshan, Fatemeh Seifar, Farid Hajibonabi, Farzad Salmannezhad Khorami
Periampullary tumors are highly malignant masses with poor prognosis. Surgical resection is the only treatment for patients with this disease. The preoperative evaluation of masses is essential to determine the tumor resectability and vascular invasion. The aim of this study was to determine the diagnostic accuracy of 64-slice multi-detector computed tomography (MDCT) in detecting the resectability of periampullary masses. A cross-sectional study was conducted on patients with a definite diagnosis of periampullary cancer...
April 27, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29680448/the-role-of-intraoperative-radiotherapy-iort-in-the-management-of-patients-with-pancreatic-and-periampullary-cancer-a-single-center-experience
#7
Ayman Zaki Azzam, Ahmed Alqarni, Tarek Mahmoud Amin
BACKGROUND: In spite of the advances in modern surgery, the outcome for patients suffering from pancreatic adenocarcinoma or periampullary adenocarcinoma is still bad. Recently, introperative radiotherapy (IORT) was introduced into the multimodality management approach to improve both tumor control and patient' survival. AIM OF WORK: To evaluate our initial experience in combined surgical resection and IORT, and to evaluate the feasibility of the application of IORT and its effect on morbidity, mortality and local recurrence...
April 18, 2018: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/29589102/dilemmas-for-the-pathologist-in-the-oncologic-assessment-of-pancreatoduodenectomy-specimens-an-overview-of-different-grossing-approaches-and-the-relevance-of-the-histopathological-characteristics-in-the-oncologic-assessment-of-pancreatoduodenectomy-specimens
#8
REVIEW
Eline Soer, Lodewijk Brosens, Marc van de Vijver, Frederike Dijk, Marie-Louise van Velthuysen, Arantza Farina-Sarasqueta, Hans Morreau, Johan Offerhaus, Lianne Koens, Joanne Verheij
A pancreatoduodenectomy specimen is complex, and there is much debate on how it is best approached by the pathologist. In this review, we provide an overview of topics relevant for current clinical practice in terms of gross dissection, and macro- and microscopic assessment of the pancreatoduodenectomy specimen with a suspicion of suspected pancreatic cancer. Tumor origin, tumor size, degree of differentiation, lymph node status, and resection margin status are universally accepted as prognostic for survival...
March 27, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29580215/nomograms-predict-long-term-survival-for-patients-with-periampullary-adenocarcinoma-after-pancreatoduodenectomy
#9
Chaobin He, Yize Mao, Jun Wang, Fangting Duan, Xiaojun Lin, Shengping Li
BACKGROUND: The prognosis of patients with periampullary adenocarcinoma after pancreatoduodenectomy is diverse and not yet clearly illustrated. The aim of this study was to develop a nomogram to predict individual risk of overall survival (OS) and progression-free survival (PFS) in patients with periampullary adenocarcinoma after pancreatoduodenectomy. METHODS: A total of 205 patients with periampullary adenocarcinoma after pancreatoduodenectomy were retrospectively included...
March 27, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29564166/advanced-age-does-not-increase-morbidity-in-pancreaticoduodenectomy
#10
Guilherme Naccache Namur, Anna Carolina Batista Dantas, Ricardo Jureidini, Thiago Costa Ribeiro, Ulysses Ribeiro Junior, Estela Figueira, Ivan Cecconello, Telesforo Bacchella
Background: Due to rising life expectancy of population, very complex surgical procedures such as pancreaticoduodenectomy (PD), are more commonly being performed in elderly patients. The objective of this study was to evaluate the safety of PD in patients older than 75 years old and the risk factors associated with severe complications. Methods: Patients who underwent PD for periampullary tumors were retrospectively reviewed and divided into two groups, A (<75 years) and B (>75 years)...
February 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29540182/relationship-between-mismatch-repair-immunophenotype-and-long-term-survival-in-patients-with-resected-periampullary-adenocarcinoma
#11
Margareta Heby, Sebastian Lundgren, Björn Nodin, Jacob Elebro, Jakob Eberhard, Karin Jirström
BACKGROUND: Periampullary adenocarcinomas, including pancreatic cancer, are a heterogeneous group of tumors with poor prognosis, where classification into intestinal type (I-type) or pancreatobiliary type (PB-type) is a relevant prognostic factor. The clinical significance of deficient mismatch repair (dMMR) in periampullary adenocarcinoma is comparatively unexplored. Herein, we examined the associations of MMR immunophenotype with long-term survival in patients with resected periampullary adenocarcinoma, with particular reference to morphology and adjuvant treatment response...
March 14, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29521943/the-dutch-pancreas-biobank-within-the-parelsnoer-institute-a-nationwide-biobank-of-pancreatic-and-periampullary-diseases
#12
Marin Strijker, Arja Gerritsen, Jony van Hilst, Maarten F Bijlsma, Bert A Bonsing, Lodewijk A Brosens, Marco J Bruno, Ronald M van Dam, Frederike Dijk, Casper H van Eijck, Arantza Farina Sarasqueta, Paul Fockens, Michael F Gerhards, Bas Groot Koerkamp, Erwin van der Harst, Ignace H de Hingh, Jeanin E van Hooft, Clément J Huysentruyt, Geert Kazemier, Joost M Klaase, Cornelis J van Laarhoven, Hanneke W van Laarhoven, Mike S Liem, Vincent E de Meijer, L Bengt van Rijssen, Hjalmar C van Santvoort, Mustafa Suker, Judith H Verhagen, Joanne Verheij, Hein W Verspaget, Roos A Wennink, Johanna W Wilmink, I Quintus Molenaar, Marja A Boermeester, Olivier R Busch, Marc G Besselink
OBJECTIVES: Large biobanks with uniform collection of biomaterials and associated clinical data are essential for translational research. The Netherlands has traditionally been well organized in multicenter clinical research on pancreatic diseases, including the nationwide multidisciplinary Dutch Pancreatic Cancer Group and Dutch Pancreatitis Study Group. To enable high-quality translational research on pancreatic and periampullary diseases, these groups established the Dutch Pancreas Biobank...
April 2018: Pancreas
https://www.readbyqxmd.com/read/29492936/alkalin-phosphatase-is-a-predictive-factor-of-unresecability-in-ampullary-and-periampullary-tumors
#13
Imen Samaali, Ibtissem Bouasker, Héla Khézami, Akram Sbai, Mohamed Wejih Dougaz, Hichem Jarraya, Ramzi Nouira, Chadli Dziri
BACKGROUND: Patients with malignant obstructive jaundice should undergo surgery on the basis of results of preoperative imaging. However, about half of patients are found to be unsuitable forresection during surgical exploration. Our study aimed to determine the clinicobiologicalcharacteristics that predict the resecability of ampullary and periampullary tumors. METHODS: We retrospectively reviewed the medical records of 49 patients (45% men and 55% women) who had malignant obstructive jaundice collected in the Department B of generalsurgery, Charles Nicolle hospital between July 1, 2008 and December 31, 2013...
April 2017: La Tunisie Médicale
https://www.readbyqxmd.com/read/29464064/translational-study-reveals-a-two-faced-role-of-rbm3-in-pancreatic-cancer-and-suggests-its-potential-value-as-a-biomarker-for-improved-patient-stratification
#14
Emelie Karnevi, Liv Ben Dror, Adil Mardinoglu, Jacob Elebro, Margareta Heby, Sven-Erik Olofsson, Björn Nodin, Jakob Eberhard, William Gallagher, Mathias Uhlén, Karin Jirström
Periampullary adenocarcinoma, including pancreatic cancer, is a heterogeneous group of tumors with dismal prognosis, partially due to lack of reliable targetable and predictive biomarkers. RNA-binding motif protein 3 (RBM3) has previously been shown to be an independent prognostic and predictive biomarker in several types of cancer. Herein, we examined the prognostic value of RBM3 in periampullary adenocarcinoma, as well as the effects following RBM3 suppression in pancreatic cancer cells in vitro . RBM3 mRNA levels were examined in 176 pancreatic cancer patients from The Cancer Genome Atlas...
January 19, 2018: Oncotarget
https://www.readbyqxmd.com/read/29334528/comparison-of-laparoscopic-and-open-pancreaticoduodenectomy-for-the-treatment-of-nonpancreatic-periampullary-adenocarcinomas
#15
Ling-Wei Meng, Yun-Qiang Cai, Yong-Bin Li, He Cai, Bing Peng
BACKGROUND: Laparoscopic pancreaticoduodenectomy (LPD), a surgical option for nonpancreatic periampullary adenocarcinoma (NPPA), is a complex procedure that has become increasing popular. However, there is no consensus as to whether this technique should be performed routinely. Our aim was to evaluate the outcomes of LPD compared with open pancreaticoduodenectomy (OPD). MATERIALS AND METHODS: From October 2010 to September 2015, 58 LPDs were performed to treat NPPA and were compared with 58 OPDs, which can theoretically be carried out by laparoscopic approach...
February 2018: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/29329159/overexpression-of-the-long-noncoding-rna-homeoboxa-transcript-at-the-distal-tip-predicts-poor-prognosis-in-a-kras-independent-manner-in-periampullary-region-tumors
#16
Ozkan Balcin, Secil Ak Aksoy, Berrin Tunca, Ekrem Kaya, Unal Egeli, Gulcin Tezcan, Nesrin Ugras, Gulsah Cecener, Ozgen Isik, Halit Ziya Dundar, Omer Yerci
OBJECTIVES: Periampullary region tumors (PRTs) are the fifth highest cause of cancer-related deaths worldwide. Although recent studies have highlighted the prognostic value of the long noncoding RNA HomeoboxA transcript at the distal tip (HOTTIP) in patients with pancreatic ductal adenocarcinoma, the relationship between HOTTIP and clinical outcome of all PRTs remains obscure. The aim of this study was to clarify the prognostic significance of HOTTIP in patients with all PRTs related to KRAS mutational status...
February 2018: Pancreas
https://www.readbyqxmd.com/read/29180841/the-role-of-eus-bd-in-the-management-of-malignant-biliary-obstruction-the-indonesian-perspective
#17
Dadang Makmun, Achmad Fauzi, Murdani Abdullah, Ari Fahrial Syam
Aims: To evaluate the success rate and related factors of endoscopic ultrasound guided-biliary drainage (EUS-BD). Material and Methods: We conducted a retrospective study among 24 patients with malignant biliary obstruction who underwent EUS-BD after failed ERCP from January 2015 to December 2016 in a tertiary health center. The bilirubin levels before and after the procedure were used to define the clinical success rate, while the stent deployment was used to define the technical success rate...
2017: Diagnostic and Therapeutic Endoscopy
https://www.readbyqxmd.com/read/29113411/pancreatoduodenectomy-combined-with-portal-superior-mesenteric-vein-resection-and-reconstruction-with-interposition-grafts-for-cancer-a-meta-analysis
#18
Wei Song, Qifan Yang, Linghui Chen, Qiang Sun, Dongkai Zhou, Song Ye, Zhenhua Hu, Liming Wu, Liming Feng, Shusen Zheng, Weilin Wang
The use of interposition grafts for portal-superior mesenteric vein (PV-SMV) reconstruction during pancreatoduodenectomy (PD) with venous resection (VR) for localized periampullary tumors is a controversial topic. The present meta-analysis aimed to evaluate the perioperative and long-term outcomes in patients who received interposition grafts for PV-SMV reconstruction after PD with VR. The correlative databases were systematically searched to identify relevant trials comparing vein grafts versus no vein grafts during PD with VR...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29097875/trends-and-outcomes-of-pancreaticoduodenectomy-for-periampullary-tumors-a-25-year-single-center-study-of-1000-consecutive-cases
#19
Ayman El Nakeeb, Waleed Askar, Ehab Atef, Ehab El Hanafy, Ahmad M Sultan, Tarek Salah, Ahmed Shehta, Mohamed El Sorogy, Emad Hamdy, Mohamed El Hemly, Ahmed A El-Geidi, Tharwat Kandil, Mohamed El Shobari, Talaat Abd Allah, Amgad Fouad, Mostafa Abu Zeid, Ahmed Abu El Eneen, Nabil Gad El-Hak, Gamal El Ebidy, Omar Fathy, Ahmed Sultan, Mohamed Abdel Wahab
AIM: To evaluate the evolution, trends in surgical approaches and reconstruction techniques, and important lessons learned from performing 1000 consecutive pancreaticoduodenectomies (PDs) for periampullary tumors. METHODS: This is a retrospective review of the data of all patients who underwent PD for periampullary tumor during the period from January 1993 to April 2017. The data were categorized into three periods, including early period (1993-2002), middle period (2003-2012), and late period (2013-2017)...
October 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29017672/surgical-outcome-of-pancreaticoduodenectomy-in-pancreatic-and-periampullary-neoplasms
#20
Muhammad Fahd Shah, Muhammad Taqi Pirzada, Irfan Ul Islam Nasir, Awais Amjad Malik, Umer Farooq, Abdul Wahid Anwer, Shahid Khattak, Muhammad Aasim Yusuf, Amir Ali Syed, Faisal Hanif
OBJECTIVE: To report the results in the surgical treatment of pancreatic and periampullary neoplasms with emphasis on surgical technique, short-term postoperative outcome and the lessons learnt. STUDY DESIGN: Case series. PLACE AND DURATION OF STUDY: This study was carried out at Shaukat Khanum Memorial Cancer Hospital and Research Center, Lahore, from October 2014 to May 2016. METHODOLOGY: Patients undergoing surgical treatment of pancreatic and periampullary neoplasms were selected...
September 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
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