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Pretransplant in childrens

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https://www.readbyqxmd.com/read/28052602/optn-srtr-2015-annual-data-report-intestine
#1
J M Smith, M A Skeans, S P Horslen, E B Edwards, A M Harper, J J Snyder, A K Israni, B L Kasiske
Intestine and intestine-liver transplant remains important in the treatment of intestinal failure, despite decreased morbidity associated with parenteral nutrition. In 2015, 196 new patients were added to the intestine transplant waiting list, with equal numbers waiting for intestine and intestine-liver transplant. Among prevalent patients on the list at the end of 2015, 63.3% were waiting for an intestine transplant and 36.7% were waiting for an intestine-liver transplant. The pretransplant mortality rate decreased dramatically over time for all age groups...
January 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/27941778/cytogenetics-and-outcome-of-allogeneic-transplantation-in-first-remission-of-acute-myeloid-leukemia-the-french-pediatric-experience
#2
A-L Alloin, G Leverger, J-H Dalle, C Galambrun, Y Bertrand, A Baruchel, A Auvrignon, V Gandemer, C Ragu, A Loundou, C Bilhou-Nabera, M Lafage-Pochitaloff, N Dastugue, B Nelken, C Jubert, F Rialland, G Plat, C Pochon, J-P Vannier, P-S Rohrlich, J Kanold, P Lutz, A Sirvent, C Oudin, W Cuccuini, G Michel
We analyzed the impact of cytogenetics on 193 children enrolled in two successive French trials (LAME89/91 and ELAM02), who received hematopoietic stem cell transplantation during CR1. Detailed karyotype was available for 66/74 (89%) in LAME89/91 and 118/119 (99%) in ELAM02. Several karyotype and transplant characteristics differed according to therapeutic protocol: unfavorable karyotypes were more frequent in ELAM02 (36% vs 18%), pretransplant chemotherapy included high-dose cytarabine in ELAM02 and not in LAME89/91, IV replaced oral busulfan in the conditioning regimen, methotrexate was removed from post-transplant immunosuppression, and matched unrelated donor and cord blood transplantation were introduced...
December 12, 2016: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/27933693/heart-transplantation-in-children-with-intellectual-disability-an-analysis-of-the-unos-database
#3
Alexander N Goel, Amit Iyengar, Kenneth Schowengerdt, Andrew C Fiore, Charles B Huddleston
Heart transplantation in children with intellectual disability (ID) is an issue of debate due to the shortage of available donor organs. We sought to perform the first large-scale retrospective cohort study describing the prevalence and outcomes of heart transplantation in this population. The United Network of Organ Sharing database was queried from 2008 to 2015 for pediatric patients (age <19 years) receiving first, isolated heart transplant. Recipients were divided into three subgroups: definite ID, probable ID, and no ID...
December 9, 2016: Pediatric Transplantation
https://www.readbyqxmd.com/read/27931577/liver-transplantation-in-polish-children-with-%C3%AE-1-antitrypsin-deficiency-a-single-center-experience
#4
A Bakula, J Pawlowska, O Niewiadomska, I Jankowska, M Teisseyre, P Kaliciński, P Socha
BACKGROUND: α1-Antitrypsin deficiency (ATD) is the most common genetic cause of liver injury in young children. Asymptomatic hepatitis is observed in most patients. However, the course of liver disease due to ATD is unpredictable, and some children develop liver cirrhosis. Liver transplantation (Ltx) dramatically improves their outcome and in some cases is required in the first years of life. The aim of the study was to evaluate the course of the disease in children with ATD treated with Ltx in a single center...
December 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27929334/the-interactive-effect-of-parent-personality-and-medication-knowledge-on-adherence-in-children-awaiting-solid-organ-transplantation
#5
Jennifer L Lee, Cyd K Eaton, Kristin Loiselle Rich, Bonney Reed-Knight, Rochelle S Liverman, Laura L Mee, Ana M Gutierrez-Colina, Rene Romero, Ronald L Blount
OBJECTIVE: The study aimed to examine parent personality factors as predictors of parent medication knowledge and parent-report of child medication adherence. METHOD: Seventy-eight parents (Mage = 37.68, 87.2% female) of children (Mage = 8.89, range: 0-20 years) undergoing evaluation for a solid organ transplant were recruited. Parents completed questionnaires about their personality, knowledge of their child's medications, and their child's level of medication adherence...
December 8, 2016: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/27885788/barriers-to-live-donor-kidney-transplants-in-the-pediatric-population-a-single-center-experience
#6
Shibany P Taormina, Matthew P Galloway, Amrish Jain
A decrease in live donor pediatric kidney transplants has occurred in the United States. This study investigates barriers that may influence access to live donor kidney transplants in children. Retrospective chart review was conducted for 91 children (69% male, mean age 11.9 years) who underwent pretransplant workup from 2005 to 2015 at an urban pediatric hospital. Fifty-four percent were African American, 32% Caucasian, 8% Arabic, 3% Hispanic, and 3% Others. Government-sponsored insurance (Medicaid/Medicare) was utilized by 73%, and 54% had dual caregivers...
November 25, 2016: Pediatric Transplantation
https://www.readbyqxmd.com/read/27748554/pretransplant-paranasal-sinus-disease-is-associated-with-a-high-incidence-of-transplant-related-mortality-in-hematopoietic-stem-cell-transplantation-for-children-and-adolescents
#7
Kenji Kishimoto, Ryoji Kobayashi, Daiki Hori, Hirozumi Sano, Daisuke Suzuki, Kazue Yasuda, Kunihiko Kobayashi
To determine whether pretransplant PSD affects the clinical outcomes in HSCT, a retrospective cohort analysis of 73 pediatric and adolescent patients who underwent HSCT was performed. Pretransplant PSD was defined as the presence of a fluid level or mucosal swelling or total opacity on sinus X-ray or CT examination performed before HSCT. Pretransplant PSD was observed in 21 (29%) patients. The probability of 2-year OS after HSCT was 42% in patients with pretransplant PSD (PSD group), and 64% in those without (non-PSD group) (P=...
October 17, 2016: Pediatric Transplantation
https://www.readbyqxmd.com/read/27737772/the-second-pediatric-blood-and-marrow-transplant-consortium-international-consensus-conference-on-late-effects-after-pediatric-hematopoietic-cell-transplantation-defining-the-unique-late-effects-of-children-undergoing-hematopoietic-cell-transplantation-for
#8
REVIEW
Andrew C Dietz, Christine N Duncan, Blanche P Alter, Dorine Bresters, Morton J Cowan, Luigi Notarangelo, Philip S Rosenberg, Shalini Shenoy, Roderick Skinner, Mark C Walters, John Wagner, K Scott Baker, Michael A Pulsipher
An international consensus conference sponsored by the Pediatric Blood and Marrow Transplant consortium entitled "Late Effects Screening and Recommendations Following Allogeneic Hematopoietic Cell Transplant for Immune Deficiency and Nonmalignant Hematologic Disease" was held in Minneapolis, Minnesota on May 10, 2016 and May 11, 2016. The purpose of the conference was to address the unmet need for greater understanding of and the screening for long-term complications in the growing population of survivors of transplantation for nonmalignant disorders...
January 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/27595243/pretransplant-panel-reactive-antibodies-and-lung-transplant-outcomes-in-children
#9
Don Hayes, Benjamin T Kopp, Shahid I Sheikh, Richard D Shell, Grace R Paul, Patrick I McConnell, Joseph D Tobias, Dmitry Tumin
Background Pre-lung transplant (LTx) panel reactive antibody (PRA) levels are associated with adverse outcomes in adult LTx recipients, but their impact in pediatric LTx recipients is unknown. Methods The United Network for Organ Sharing registry was queried from 2004 to 2013 to compare survival between pediatric LTx recipients with PRA class I and II levels = 0 versus > 0. Results Overall, 333 pediatric LTx recipients had data on class I or II PRA and were included in the analysis. Univariate analysis demonstrated that PRA > 0 was not associated with survival benefit for class I (hazard ratio [HR] = 0...
January 2017: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/27500272/successful-kidney-transplantation-in-children-with-a-compromised-inferior-vena-cava
#10
Seiichiro Shishido, Takeshi Kawamura, Yuko Hamasaki, Yusuke Takahashi, Yoshihiro Itabashi, Masaki Muramatsu, Hiroyuki Satoh, Atsushi Aikawa
BACKGROUND: Children with a compromised inferior vena cava (IVC) were previously considered unsuitable for kidney transplantation because of the technical difficulties and the increased risk of graft thrombosis secondary to inadequate renal venous outflow. METHODS: We conducted a retrospective study of 11 transplants in 9 patients with end-stage renal disease and thrombosed IVCs who received adult kidney allografts between 2000 and 2015. The mean age at transplantation was 7...
June 2016: Transplantation Direct
https://www.readbyqxmd.com/read/27463537/immune-desensitization-allows-pediatric-blood-group-incompatible-kidney-transplantation
#11
Jelena Stojanovic, Anna Adamusiak, Nicos Kessaris, Pankaj Chandak, Zubir Ahmed, Neil J Sebire, Grainne Walsh, Helen E Jones, Stephen D Marks, Nizam Mamode
BACKGROUND: Blood group incompatible transplantation (ABOi) in children is rare as pretransplant conditioning remains challenging and concerns persist about the potential increased risk of rejection. METHODS: We describe the results of 11 ABOi pediatric renal transplant recipients in the 2 largest centers in the United Kingdom, sharing the same tailored desensitization protocol. Patients with pretransplant titers of 1 or more in 8 received rituximab 1 month before transplant; tacrolimus and mycophenolate mofetil were started 1 week before surgery...
July 12, 2016: Transplantation
https://www.readbyqxmd.com/read/27403776/outcomes-following-bone-marrow-transplantation-in-children-with-accelerated-phase-or-blast-crisis-chronic-myelogenous-leukemia-in-the-era-of-tyrosine-kinase-inhibitors
#12
David S Shulman, Michelle A Lee, Leslie E Lehmann, Steven P Margossian
The management of chronic myelogenous leukemia (CML) in children changed dramatically with the introduction of tyrosine kinase inhibitors (TKIs). Unfortunately, outcomes for patients presenting in an advanced stage-accelerated phase or blast crisis CML-continues to be poor, requiring chemotherapy and allogeneic hematopoietic stem cell transplant (HSCT) to attempt cure. Integration of TKIs in the therapy of advanced CML is still an area of active investigation. There are little published data on TKI use in children with advanced stage CML...
November 2016: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/27254644/looking-outside-summer-camp-for-children-who-have-undergone-a-solid-organ-transplant
#13
Jacob L Bilhartz, Amy K Drayton, Victoria L Shieck
A high-quality critical care team is an essential component of any successful organ transplant program. From pretransplant care to the crucial postoperative period, its importance cannot be discounted. However, because of the focused nature of work in an intensive care unit (ICU), all too often members of the ICU team are not able to see and appreciate the ultimate fruits of their labor. These are factors that can contribute to the high rates of burnout and turnover among ICU teams. This article presents the concept of a summer camp for children who have received a solid-organ transplant...
July 2016: Critical Care Nursing Quarterly
https://www.readbyqxmd.com/read/27139146/posterior-reversible-encephalopathy-syndrome-after-pediatric-heart-transplantation-increased-risk-for-children-with-preexisting-glenn-fontan-physiology
#14
Braiden Eilers, Erin Albers, Yuk Law, D Mike McMullan, Dennis Shaw, Mariska Kemna
Identification of risk factors for PRES after organ transplant can improve early detection and avoid permanent neurological injury. High calcineurin-inhibitor levels and hypertension are recognized risk factors for PRES in adult transplant recipients. Limited data exist regarding PRES after pediatric HTx, with studies limited to case reports. We performed a retrospective review of 128 pediatric HTx recipients to identify risk factors for PRES. Seven of 128 (5.5%) recipients developed PRES at a median of 10 days (5-57) after HTx...
June 2016: Pediatric Transplantation
https://www.readbyqxmd.com/read/27094103/prognostic-factors-and-a-new-prognostic-index-model-for-children-and-adolescents-with-hodgkin-s-lymphoma-who-underwent-autologous-hematopoietic-stem-cell-transplantation-a-multicenter-study-of-the-turkish-pediatric-bone-marrow-transplantation-study-group
#15
Vural Kesik, Erman Ataş, Musa Karakükcü, Serap Aksoylar, Fatih Erbey, Nurdan Taçyıldız, Alphan Küpesiz, Haldun Öniz, Ekrem Ünal, Savaş Kansoy, Gülyüz Öztürk, Murat Elli, Zühre Kaya, Emel Ünal, Volkan Hazar, Şebnem Yılmaz Bengoa, Gülsün Karasu, Didem Atay, Ayhan Dağdemir, Hale Ören, Ülker Koçak, M Akif Yeşilipek
OBJECTIVE: The prognostic factors and a new childhood prognostic index after autologous hematopoietic stem cell transplantation (AHSCT) in patients with relapsed/refractory Hodgkin's lymphoma (HL) were evaluated. MATERIALS AND METHODS: The prognostic factors of 61 patients who underwent AHSCT between January 1990 and December 2014 were evaluated. In addition, the Age-Adjusted International Prognostic Index and the Childhood International Prognostic Index (CIPI) were evaluated for their impact on prognosis...
December 1, 2016: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/27032470/era-effect-on-survival-following-paediatric-heart-transplantation
#16
Bahaaldin Alsoufi, Shriprasad Deshpande, Courtney McCracken, Brian Kogon, Robert Vincent, William T Mahle, Kirk Kanter
OBJECTIVES: Paediatric heart transplantation is performed to salvage children with end-stage heart failure from various underlying pathologies. Despite several developments in all management aspects of transplantation candidates, the effect of those advances on outcomes has not been consistent. We report our institutional experience with focus on examining era effect on early and late survival. METHODS: Between 1988 and 2015, 320 children underwent heart transplantation...
October 2016: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/26950712/predicting-cellular-rejection-with-a-cell-based-assay-preclinical-evaluation-in-children
#17
Chethan Ashokkumar, Kyle Soltys, George Mazariegos, Geoffrey Bond, Brandon W Higgs, Mylarappa Ningappa, Qing Sun, Amanda Brown, Jaimie White, Samantha Levy, Tamara Fazzolare, Lisa Remaley, Katie Dirling, Patricia Harris, Tara Hartle, Pamela Kachmar, Megan Nicely, Lindsay OʼToole, Brittany Boehm, Nicole Jativa, Paula Stanley, Ronald Jaffe, Sarangarajan Ranganathan, Adriana Zeevi, Rakesh Sindhi
BACKGROUND: Allospecific CD154+T-cytotoxic memory cells (CD154+TcM) predict acute cellular rejection after liver transplantation (LTx) or intestine transplantation (ITx) in small cohorts of children and can enhance immunosuppression management, but await validation and clinical implementation. METHODS: To establish safety and probable benefit, CD154+TcM were measured in cryopreserved samples from 214 children younger than 21 years (National Clinical Trial 1163578)...
January 2017: Transplantation
https://www.readbyqxmd.com/read/26913620/a-randomized-clinical-trial-of-a-parent-focused-social-cognitive-processing-intervention-for-caregivers-of-children-undergoing-hematopoetic-stem-cell-transplantation
#18
RANDOMIZED CONTROLLED TRIAL
Sharon Manne, Laura Mee, Abraham Bartell, Stephen Sands, Deborah A Kashy
OBJECTIVE: Providing care to one's child during and after a hematopoietic stem cell transplant (HSCT) is a universally stressful experience, but few psychological interventions have been developed to reduce caregiver distress. The goal of this study was to test the efficacy of a brief cognitive-behavioral intervention delivered to primary caregivers. METHOD: Two hundred eighteen caregivers were assigned either best-practice psychosocial care (BPC) or a parent social-cognitive intervention program (P-SCIP)...
May 2016: Journal of Consulting and Clinical Psychology
https://www.readbyqxmd.com/read/26867571/pretransplant-stable-systolic-cardiac-functions-play-an-important-role-in-short-term-systolic-cardiac-functions-after-kidney-transplant-in-children
#19
Caner Alparslan, Onder Yavascan, Murat Sait Doğan, Serdar Saritas, Fatma Mutlubas Ozsan, Belde Kasap Demir, Ali Rahmi Bakiler, Nejat Aksu
OBJECTIVES: In this study, our aim was to evaluate the systolic cardiac parameters and related risk factors in children within 6 months after kidney transplant. MATERIALS AND METHODS: We retrospectively evaluated 24 children who received kidney transplants. Clinical and laboratory parameters before and after transplant were recorded. Results were evaluated statistically, with a P value less than .05 considered significant. RESULTS: Before transplant, systolic cardiac functions were within normal limits...
February 11, 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/26847771/vaccinations-response-and-controls-before-and-after-intestinal-transplantation-in-children
#20
Z Demir, P Frange, F Lacaille
Vaccination is an effective strategy to decrease infections in transplant recipients. Children after intestinal transplantation carry a high risk of infection due to increased immunosuppression. In a series of 22 children after intestinal transplantation, we studied the vaccination schedules and the antibodies against vaccine-preventable diseases before transplantation, and at one and five yr after transplantation. We reviewed whether the vaccination schedules were complete, and we analysed the factors that may influence serological immunity and the incidence of disease in patients with deficient immunity...
May 2016: Pediatric Transplantation
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