Cédric Langhi, Marie Vallier, Auriane Bron, Yolanda F Otero, Maheva Maura, Florian Le Joubioux, Niek Blomberg, Martin Giera, Bruno Guigas, Thierry Maugard, Benoit Chassaing, Sébastien Peltier, Stéphanie Blanquet-Diot, Jean-Marie Bard, Pascal Sirvent
INTRODUCTION: Totum-070 is a combination of five plant extracts enriched in polyphenols to target hypercholesterolemia, one of the main risk factors for cardiovascular diseases. The aim of this study was to investigate the effects of Totum-070 on cholesterol levels in an animal model of diet-induced hypercholesterolemia. METHODS: C57BL/6JOlaHsd male mice were fed a Western diet and received Totum-070, or not, by daily gavage (1g/kg and 3g/kg body weight) for 6 weeks...
2024: Frontiers in Cardiovascular Medicine