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Pancreatic necrosis

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https://www.readbyqxmd.com/read/28077129/hypoglycemic-and-pancreatic-protective-effects-of-portulaca-oleracea-extract-in-alloxan-induced-diabetic-rats
#1
Basma K Ramadan, Mona F Schaalan, Amina M Tolba
BACKGROUND: Diabetes is a major public health concern. In spite of continuous new drug development to treat diabetes, herbal remedies remain a potential adjunct therapy to maintain better glycemic control while also imparting few side-effects. Portulaca oleracea has been traditionally used to manage several diseases due to the anti-oxidant and anti-atherogenic effects it imparts. To better understand the mechanisms associated with potential protective effect of P. oleracea extract against diabetes, alloxan-induced diabetic rats were used in this study...
January 11, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28060696/acute-pancreatitis-and-posterior-reversible-encephalopathy-syndrome-a-case-report
#2
Vítor Magno Pereira, Luís Marote Correia, Tiago Rodrigues, Gorete Serrão Faria
The posterior reversible encephalopathy syndrome is a neurological syndrome characterized by headache, confusion, visual disturbances and seizures associated with identifiable areas of cerebral edema on imaging studies. The authors report the case of a man, 33 years-old, leukodermic with a history of chronic alcohol and tobacco consumption, who is admitted to the emergency department for epigastric pain radiating to the back and vomiting with about six hours of evolution and an intense holocranial headache for two hours...
September 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28052102/irreversible-electroporation-of-the-pancreas-using-parallel-plate-electrodes-in-a-porcine-model-a-feasibility-study
#3
Steffi J E Rombouts, Maarten W Nijkamp, Willemijn P M van Dijck, Lodewijk A A Brosens, Maurits Konings, R van Hillegersberg, Inne H M Borel Rinkes, Jeroen Hagendoorn, Fred H Wittkampf, I Quintus Molenaar
BACKGROUND: Irreversible electroporation (IRE) with needle electrodes is being explored as treatment option in locally advanced pancreatic cancer. Several studies have shown promising results with IRE needles, positioned around the tumor to achieve tumor ablation. Disadvantages are the technical difficulties for needle placement, the time needed to achieve tumor ablation, the risk of needle track seeding and most important the possible occurrence of postoperative pancreatic fistula via the needle tracks...
2017: PloS One
https://www.readbyqxmd.com/read/28033740/intestinal-malrotation-and-replaced-common-hepatic-artery-during-duodenopancreatectomy-a-case-report
#4
Alexander Schank, Philippe Colonval, Mikhaël Salame
BACKGROUND: Intestinal malrotation is a well-known anomaly in the normal rotation process of the midgut during embryogenesis. Multiple forms are described, resulting in various positional configurations of the small bowel and colon. Replaced common hepatic artery is a rare but not anecdotic variant of the standard hepatic vascularization, associated with surgical implications. Our aim is to explain the impact of their simultaneous presence during this procedure and the difficulty in identifying them preoperatively, despite imaging...
December 29, 2016: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/28032656/eus-guided-drainage-of-pancreatic-fluid-collections
#5
REVIEW
Tiing Leong Ang, Anthony Yuen Bun Teoh
Endoscopic ultrasound (EUS)-guided drainage is now firmly established as the best option for drainage of walled-off pancreatic fluid collections (PFC). It has high clinical efficacy, similar to surgical and percutaneous approaches, but with lower morbidity and costs. It is superior to non-EUS guided approaches because even collections without endoluminal bulging can be successfully drained. Transmural drainage alone is sufficient for pseudocysts, but in the context of walled-off pancreatic necrosis (WON), adjunctive direct endoscopic necrosectomy (DEN) may be required...
December 29, 2016: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28032357/in-vivo-study-of-viral-haemorrhagic-septicaemia-virus-and-infectious-pancreatic-necrosis-virus-coexistence-in-senegalese-sole-solea-senegalensis
#6
C López-Vázquez, M C Alonso, C P Dopazo, I Bandín
The effect of IPNV-VHSV coinfection and superinfection on the mortality caused by both viruses in Senegalese sole has been analysed. No effect was observed after coinfection. However, a clear viral interference was recorded between a primary IPNV and a subsequent VHSV infection, which led to a survival increase in the infected sole of 50% points when compared with fish infected only with VHSV. The significantly higher Mx transcriptional values in the fish pre-exposed to IPNV (at least at first days after superinfection) and the increased daily mortality when low Mx transcriptional levels were recorded suggest that Mx may be involved in the protective effect against VHSV infection...
December 29, 2016: Journal of Fish Diseases
https://www.readbyqxmd.com/read/28026015/design-and-validation-of-a-rt-qpcr-procedure-for-diagnosis-and-quantification-of-most-types-of-infectious-pancreatic-necrosis-virus-using-a-single-pair-of-degenerated-primers
#7
D Vázquez, J M Cutrín, J G Olveira, C P Dopazo
Infectious pancreatic necrosis virus (IPNV) is an important virus which affects the salmonid aquaculture industry worldwide; therefore, it is important to develop rapid and reliable methods of diagnosis to detect the disease at early stages. Nowadays, RT-qPCR is replacing other methods because it provides additional information on the viral load, which is important to have a better understanding of the virus replication level and of the stage of the infection and its risk level. The main problem stems from the high diversity of this virus, which can compromise the reliability of the diagnosis...
December 27, 2016: Journal of Fish Diseases
https://www.readbyqxmd.com/read/28024851/deficiency-of-%C3%AE-%C3%AE-t-cells-protects-against-abdominal-aortic-aneurysms-by-regulating-phosphoinositide-3-kinase-akt-signaling
#8
Shuai Zhang, Xiaoyu Kan, Yulin Li, Ping Li, Congcong Zhang, Guang Li, Jie Du, Bin You
OBJECTIVE: It is known that T lymphocytes are activated in human abdominal aortic aneurysms (AAAs). γδT cells, as a subset of T cells, play a role in many inflammation-related diseases. However, whether γδT cells participate in the formation of AAA remains unknown. In this study, we explored the role of γδT cells in AAA lesions. METHODS AND RESULTS: Using the porcine pancreatic elastase-induced AAA model, we found that knock out of γδT cells significantly attenuated AAA formation...
December 23, 2016: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28012776/a-novel-in-feed-delivery-platform-applied-for-oral-dna-vaccination-against-ipnv-enables-high-protection-in-atlantic-salmon-salmon-salar
#9
Miguel Reyes, Cesar Ramírez, Ivan Ñancucheo, Ricardo Villegas, Guillermo Schaffeld, Luis Kiman, Javier Gonzalez, Patricio Oyarzun
BACKGROUND: DNA vaccination has emerged as a promising tool against infectious diseases of farmed fish. Oral delivery allows stress-free administration that is ideal for mass immunization and of paramount importance for infectious pancreatic necrosis (IPN) and other viral disease that affect young salmonids and cause economic losses in aquaculture worldwide. METHODS: We describe the development and in vivo assessment of an "in-feed" formulation strategy for oral immunization with liposomal DNA vaccines, by delivering a vaccine construct coding for an immunogenic region of the VP2 capsid protein...
December 21, 2016: Vaccine
https://www.readbyqxmd.com/read/28012340/role-of-computed-tomography-in-predicting-prognosis-of-hepatic-portal-venous-gas
#10
Makram Moussa, Inès Marzouk, Kais Abdelmoula, Amira Manamani, Nadida Dali, Leila Charrada Ben Farhat, Lotfi Hendaoui
BACKGROUND: The aim of this study was to report through 13 cases the particularities of abdominal computed tomography (CT) aspects of hepatic portal venous gas (HPVG) and its correlation with patient prognosis. METHODS: We analyzed abundance of HPVG and its association with pneumatosis intestinalis (PI) in correlation with fatal outcome using chi-square tests. RESULTS: Etiologies were mesenteric infarction (n=5), sigmoid diverticulitis (n= 1), septic shock (n=1), postoperative peritonitis (n=1), acute pancreatitis (n=1), iatrogenic cause (n=3) and idiopathic after a laparotomy (n=1)...
December 2, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28009718/the-role-of-endoscopic-intervention-in-the-management-of-inflammatory-pancreatic-fluid-collections
#11
Vikrant Parihar, Paul F Ridgway, Kevin C Conlon, Matthew Huggett, Barbara M Ryan
Pancreatic fluid collections (PFCs) are a frequent complication of pancreatitis, or less commonly, pancreatic trauma or surgery. The revised Atlanta Classification categorizes PFCs as acute or chronic, with further subclassification of acute collections into acute peripancreatic collections and acute necrotic collections and of chronic fluid collections into pseudocysts and walled-off pancreatic necrosis. Acute PFCs are generally only subjected to an intervention when they are infected and not responding to antibiotics and are not managed endoscopically...
December 22, 2016: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28007459/endothelial-markers-are-associated-with-pancreatic-necrosis-and-overall-prognosis-in-acute-pancreatitis-a-preliminary-cohort-study
#12
Yizhe Chen, Lu Ke, Lei Meng, Qi Yang, Zhihui Tong, Yiyuan Pan, Weiqin Li, Jieshou Li
BACKGROUND: Endothelial injury is believed to play an important role in the evolution of pancreatic microcirculatory dysfunction and pancreatic necrosis (PN) in patients with acute pancreatitis (AP). The aim of this study was to investigate the role of three endothelial markers (von Willebrand factor, vWF; E-selectin; endothelial protein C receptor, EPCR) in the early phase of AP, especially the relationship between endothelial markers and PN. METHODS: From March 2015 to March 2016, 57 AP patients admitted within 72 h of symptom onset in our hospital were included for this study...
December 15, 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28005211/restricted-replication-of-viral-hemorrhagic-septicemia-virus-vhsv-in-a-birnavirus-carrier-cell-culture
#13
Ricardo Parreño, Lucía Almagro, Melissa Belló-Pérez, Regla M Medina-Gali, Amparo Estepa, Luis Perez
Viral hemorrhagic septicemia virus (VHSV) and infectious pancreatic necrosis virus (IPNV) are economically important pathogens of the salmonid aquaculture industry. In previous work we demonstrated that a cell line persistently infected with IPNV (EPC(IPNV)) exhibited antiviral activity against superinfection with the heterologous virus VHSV. This work extends our study by analyzing the replication of VHSV in the IPNV-persistently infected cells. At early and late stages of infection VHSV RNA synthesis, as well as VHSV-induced syncytia formation, were examined in EPC(IPNV) cultures...
December 22, 2016: Archives of Virology
https://www.readbyqxmd.com/read/28004006/the-different-effects-of-atorvastatin-and-pravastatin-on-cell-death-and-parp-activity-in-pancreatic-nit-1-cells
#14
Ya-Hui Chen, Yi-Chun Chen, Chin-San Liu, Ming-Chia Hsieh
Statins have been widely used drugs for lowering low-density lipoprotein and for preventing heart attack and stroke. However, the increased risk for developing diabetes during extended stain use and the molecular mechanisms remain unclear. The objective of this study was to elucidate the signaling pathway and biological function between necrosis and autophagy induced by atorvastatin (AS) and pravastatin (PS). Here we observed that atorvastatin (AS) can increase intracellular reactive oxygen species (ROS) and induce necrotic cell death and autophagy in NIT-1 cells, whereas pravastatin (PS) does not cause ROS and cell death but also induces autophagy...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28000693/consumption-of-a-high-fat-breakfast-on-consecutive-days-alters-preclinical-biomarkers-for-atherosclerosis
#15
B K McFarlin, K C Carpenter, A L Henning, A S Venable
BACKGROUND/OBJECTIVES: Recent research has speculated that the risk of developing atherosclerosis is due to the accumulation of the effects of daily diet choices. The purpose of this study was to examine which of our previously identified preclinical disease risk biomarkers were further elevated when consuming a high-fat (644±50 kcal; 100% recommended dietary allowance for fat), high-calorie (1118±100 kcal; 70% daily caloric needs) breakfast on consecutive days. Young, normal weight females (N=7) participated in this study...
December 21, 2016: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27986123/effects-of-castanospermine-on-inflammatory-response-in-a-rat-model-of%C3%A2-experimental-severe-acute-pancreatitis
#16
Yu-Pu Hong, Chen Chen, Wen-Yi Guo, Liang Zhao, Fang-Chao Mei, Ming-Wei Xiang, Wei-Xing Wang
BACKGROUND AND AIMS: Acute pancreatitis (AP) is an acute inflammatory disorder characterized by autodigestion of pancreatic tissue resulting in local pancreatic injury or systemic inflammatory response. Castanospermine (CAST) is an alkaloid from the Castanospermum australe, known as an anti-inflammatory agent and immunosuppressant in animal experiments. However, whether CAST can attenuate AP remains unclear. This study investigated the effects of CAST on sodium taurocholate (STC)-induced severe acute pancreatitis (SAP) in rats and the pertinent mechanism...
August 2016: Archives of Medical Research
https://www.readbyqxmd.com/read/27977628/percutaneous-irreversible-electroporation-for-pancreatic-vipoma-a-case-report
#17
Lizhi Niu, Jiannan Li, Jianying Zeng, Gang Fang, Liang Zhou, Kecheng Xu, Kai Zhang
The purpose of this study was to investigate the safety and efficacy of irreversible electroporation (IRE) for the management of unresectable pancreatic vasoactive intestinal peptide tumor (VIPoma) in a 34-year-old male patient. The initial symptom was watery diarrhea, which could not be stopped by fasting. Laboratory tests revealed high vasoactive intestinal peptide (VIP) hormone levels, hypokalemia, and metabolic acidosis. Computed tomography examination showed a 6.0 × 5.0-cm, contrast-enhanced lesion in the neck and body of the pancreas and obliteration of the portal vein...
January 2017: Pancreas
https://www.readbyqxmd.com/read/27977545/endoscopic-ultrasound-guided-drainage-of-walled-off-necrosis-in-children-with-fully-covered-self-expanding-metal-stents
#18
Zaheer Nabi, Sundeep Lakhtakia, Jahangeer Basha, Radhika Chavan, Mohan Ramchandani, Rajesh Gupta, Rakesh Kalapala, Santosh Darisetty, Rupjyoti Talukdar, D Nageshwar Reddy
BACKGROUND AND OBJECTIVE: Endoscopic ultrasound (EUS) guided drainage with fully covered self-expanding metallic stents (FCSEMS) have been successfully used in adult patients. However, the utility of FCSEMS in children with walled off necrosis (WON) is unknown. The aim of present study was to evaluate the feasibility, safety and efficacy of EUS-drainage of WON using FCSEMS in children. METHODS: We retrospectively evaluated the data of children (≤18 years) who underwent EUS-drainage of walled off necrosis (WON) using FCSEMS at our institution...
December 13, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27975299/nilotinib-a-tyrosine-kinase-inhibitor-exhibits-protection-against-acute-pancreatitis-induced-lung-and-liver-damage-in-rats
#19
Manar A Nader, Heba M Wagih
This investigation explored the nilotinib action in the management of acute pancreatitis (AP) and AP-induced lung and liver injury. AP was induced in Sprague Dawley (SD) rats with L-arginine. Treatment with nilotinib with or without L-arginine was applied for 7 days. Marked deterioration in serum amylase, lipase, aspartate amino transferase (AST), alanine amino transferase (ALT), lactate dehydrogenase (LDH), nitric oxide (NO), total protein content, and transforming growth factor beta1 (TGF-β1) along with pancreatic, hepatic, and pulmonary tissue lipid peroxidation (MDA) after induction of AP while significant reduction in tissues superoxide dismutase (SOD), glutathione (GSH) with marked edema, hemorrhage, and perivascular inflammation with acinar cell necrosis, along with elevated pancreatic percentage expression of TGF-β1 and nuclear factor kappa B (NF-κB), were observed in the AP group...
December 14, 2016: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/27960087/leveraging-an-nqo1-bioactivatable-drug-for-tumor-selective-use-of-poly-adp-ribose-polymerase-inhibitors
#20
Xiumei Huang, Edward A Motea, Zachary R Moore, Jun Yao, Ying Dong, Gaurab Chakrabarti, Jessica A Kilgore, Molly A Silvers, Praveen L Patidar, Agnieszka Cholka, Farjana Fattah, Yoonjeong Cha, Glenda G Anderson, Rebecca Kusko, Michael Peyton, Jingsheng Yan, Xian-Jin Xie, Venetia Sarode, Noelle S Williams, John D Minna, Muhammad Beg, David E Gerber, Erik A Bey, David A Boothman
Therapeutic drugs that block DNA repair, including poly(ADP-ribose) polymerase (PARP) inhibitors, fail due to lack of tumor-selectivity. When PARP inhibitors and β-lapachone are combined, synergistic antitumor activity results from sustained NAD(P)H levels that refuel NQO1-dependent futile redox drug recycling. Significant oxygen-consumption-rate/reactive oxygen species cause dramatic DNA lesion increases that are not repaired due to PARP inhibition. In NQO1(+) cancers, such as non-small-cell lung, pancreatic, and breast cancers, cell death mechanism switches from PARP1 hyperactivation-mediated programmed necrosis with β-lapachone monotherapy to synergistic tumor-selective, caspase-dependent apoptosis with PARP inhibitors and β-lapachone...
December 12, 2016: Cancer Cell
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