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Pancreatic necrosis

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https://www.readbyqxmd.com/read/29328945/astaxanthin-ameliorates-cerulein-induced-acute-pancreatitis-in-mice
#1
Hui Zhang, Wenjuan Yang, Yueyue Li, Liangkai Hu, Ying Dai, Jianqing Chen, Shuqi Xu, Xuanfu Xu, Haiqiong Jiang
BACKGROUND: A various of pharmacological effects of astaxanthin has been confirmed. However, the mechanism underlying protective effect of astaxanthin on acute pancreatitis (AP) induced by cerulein still unclear. The present study is to investigate the mechanism underlying the effect of astaxanthin on autophagy and apoptosis via the JAK/STAT3 pathway. METHODS: Intraperitoneal injection of cerulein at hourly intervals followed by lipopolysaccharide injection were used in Balb/C mice...
January 9, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29317372/pancreas-ductal-adenocarcinoma-with-cystic-features-on-cross-sectional-imaging-radiologic-pathologic-correlation
#2
Seo Yeon Youn, Sung Eun Rha, Eun Sun Jung, In Seok Lee
Most pancreatic ductal adenocarcinomas (PDAs) show solid growth pattern, but ductal adenocarcinomas may demonstrate intratumoral cystic appearance or accompany peritumoral non-neoplastic cystic lesions, thus mimicking cystic pancreatic tumors on imaging studies. The histopathologic findings for PDA with cystic feature are divided into neoplastic and non-neoplastic cysts. Neoplastic cystic changes include large-duct type cysts (microcystic appearance), neoplastic mucin cysts (macrocystic appearance), colloid carcinomas (mucinous noncystic adenocarcinomas), and degenerative cystic change usually caused by hemorrhagic necrosis of tumor...
January 2018: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/29316343/circulating-monocyte-chemoattractant-protein-1-mcp-1-is-associated-with-cachexia-in-treatment-na%C3%A3-ve-pancreatic-cancer-patients
#3
Erin E Talbert, Heather L Lewis, Matthew R Farren, Mitchell L Ramsey, Jeffery M Chakedis, Priyani Rajasekera, Ericka Haverick, Angela Sarna, Mark Bloomston, Timothy M Pawlik, Teresa A Zimmers, Gregory B Lesinski, Phil A Hart, Mary E Dillhoff, Carl R Schmidt, Denis C Guttridge
BACKGROUND: Cancer-associated wasting, termed cancer cachexia, has a profound effect on the morbidity and mortality of cancer patients but remains difficult to recognize and diagnose. While increases in circulating levels of a number of inflammatory cytokines have been associated with cancer cachexia, these associations were generally made in patients with advanced disease and thus may be associated with disease progression rather than directly with the cachexia syndrome. Thus, we sought to assess potential biomarkers of cancer-induced cachexia in patients with earlier stages of disease...
January 7, 2018: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29309791/amelioration-of-streptozotocin-induced-type-2-diabetes-mellitus-in-wistar-rats-by-arachidonic-acid
#4
Naveen K V Gundala, Vegi G M Naidu, Undurti N Das
Traditionally arachidonic acid (AA, 20:4 n-6) is considered as a pro-inflammatory molecule since it forms precursor to prostaglandins (PGs), leukotrienes (LTs) and thromboxanes (TXs) that have pro-inflammatory actions. Type 2 diabetes mellitus (type 2 DM) is considered as a low-grade systemic inflammatory condition in which circulating PGs and LTs are increased. Streptozotocin (STZ)-induced type 2 DM is used as a model of human type 2 DM in which peripheral insulin resistance, increased plasma interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) and hyperglycemia occurs...
January 5, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29301491/pancreatic-panniculitis-the-bright-side-of-the-moon-in-solid-cancer-patients
#5
Elena Guanziroli, Antonella Colombo, Antonella Coggi, Raffaele Gianotti, Angelo Valerio Marzano
BACKGROUND: Pancreatic panniculitis is a rare complication of pancreas disorders occurring in 0.3-3% of patients, most often accompanied by the pancreatic acinar carcinoma. It presents multiple, painful, deep, ill-defined, red-brown, migratory nodules and plaques of hard elastic consistency; often ulcerated and typically located on the lower proximal and distal extremities. The pathogenesis is not fully understood, but it is thought to result from lipolysis and fat necrosis with secondary tissue inflammation induced by pancreatic enzymes...
January 4, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29301065/pancreatic-necrosectomy-through-sinus-tract-endoscopy
#6
Mahesh Kumar Goenka, Usha Goenka, Md Yasin Mujoo, Indrajit Kumar Tiwary, Sanjay Mahawar, Vijay Kumar Rai
Background/Aims: Direct endoscopic pancreatic necrosectomy is increasingly being utilized to treat infected or symptomatic walled-off necrosis (WON) located close to the stomach or duodenum. Laterally-placed WON has traditionally been treated surgically. We evaluated a less utilized technique of sinus tract endoscopy (STE) for symptomatic laterally-placed WON. Methods: Two hundred seventy-six patients with acute pancreatitis admitted in our hospital, 32 had symptomatic or infected WON requiring intervention...
January 4, 2018: Clinical Endoscopy
https://www.readbyqxmd.com/read/29290653/pharmacokinetics-and-pharmacodynamics-of-shengjiang-decoction-in-rats-with-acute-pancreatitis-for-protecting-against-multiple-organ-injury
#7
Lv Zhu, Jun-Yi Li, Yu-Mei Zhang, Hong-Xin Kang, Huan Chen, Hang Su, Juan Li, Wen-Fu Tang
AIM: To explore the pharmacokinetics and pharmacodynamics of Shengjiang decoction (SJD) in rats with acute pancreatitis (AP) for protecting against multiple organ injury. METHODS: An AP model was established by retrograde perfusion of 3.5% sodium taurocholate into the biliopancreatic duct, and a control group (CG) received 0.9% sodium chloride instead. Twelve male Sprague-Dawley rats were randomly divided into a CG treated with SJD (CG + SJD) and a model group treated with SJD (MG + SJD), both of which were orally administered with SJD (5 g/kg) 2 h after surgery...
December 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29288273/pro-inflammatory-cytokines-after-an-episode-of-acute-pancreatitis-associations-with-fasting-gut-hormone-profile
#8
Sayali A Pendharkar, Ruma G Singh, Shayal K Chand, Aya Cervantes, Maxim S Petrov
INTRODUCTION: Pro-inflammatory cytokines, such as interleukin (IL)-6, tumour necrosis factor (TNF)α, and monocyte chemoattractant protein (MCP)-1, are often elevated in individuals after acute pancreatitis but what determines their levels is poorly understood. Gut hormones have emerged as possible modulators of inflammatory response. The aim was to investigate the associations between pro-inflammatory cytokines and a comprehensive panel of gut hormones after an episode of acute pancreatitis...
December 29, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29288073/fish-viruses-stored-in-rnalater-can-remain-infectious-and-even-be-temporarily-protected-from-inactivation-by-heat-or-by-tissue-homogenates
#9
Phuc H Pham, Bibi S H Sokeechand, Kyle A Garver, Ginny Jones, John S Lumsden, Niels C Bols
RNAlater is a commonly used transport and storage solution for samples collected for fish health investigations, particularly those potentially involving viruses. However, the infectivity of fish viruses after storage in RNAlater have not been determined. Nevertheless, knowledge of pathogen infectivity of preserved samples is crucial for ensuring safe transport and storage protocols. Therefore, the infectivity of three fish RNA viruses in RNAlater was examined at four temperatures: -80 °C, 4 °C, room temperature (RT, approximately 22 °C) and 37 °C...
December 26, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/29286117/angiotensin-1-7-ameliorates-caerulein-induced-inflammation-in-pancreatic-acinar-cells-by-downregulating-toll-like-receptor-4-nuclear-factor-%C3%AE%C2%BAb-expression
#10
Yan Wang, Guoxing Wang, Lijian Cui, Ruixia Liu, Hongli Xiao, Chenghong Yin
The present study aimed to investigate the effects of angiotensin (Ang) 1-7 on caerulein (CAE)-stimulated nuclear factor (NF)‑κB, Toll‑like receptor (TLR4) and cytokine expression using pancreatic acinar AR42J cells. AR42J cells were treated with 10 nmol/l CAE for various durations. In addition, cells were pretreated with various concentrations of Ang 1‑7 or A779, a specific antagonist of Ang 1‑7, and were stimulated with CAE for 12 h. Control cells were treated with vehicle (F‑12K complete medium with 2% fetal bovine serum, 10 U/ml penicillin and 100 mg/ml streptomycin) alone...
December 27, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29282638/efficacy-and-safety-of-lumen-apposing-metal-stents-in-management-of-pancreatic-fluid-collections-are-they-better-than-plastic-stents-a-systematic-review-and-meta-analysis
#11
REVIEW
Tariq Hammad, Muhammad Ali Khan, Yaseen Alastal, Wade Lee, Ali Nawras, Mohammad Kashif Ismail, Michel Kahaleh
BACKGROUND AND AIMS: Endoscopic ultrasound (EUS)-guided transmural drainage has been increasingly utilized as a first-line therapeutic modality for drainage of pancreatic fluid collections (PFC). Recently, lumen-apposing metal stents (LAMS) have been utilized for management of PFCs. We conducted a systematic review and meta-analysis to evaluate the cumulative efficacy and safety of LAMS in the management of PFC (primary outcome). We also compared the efficacy and safety of LAMS with multiple plastic stents (MPS) in the management of PFC (secondary outcome)...
December 27, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29280919/presence-extent-and-location-of-pancreatic-necrosis-are-independent-of-aetiology-in-acute-pancreatitis
#12
Robert C Verdonk, Hanna Sternby, Alexandra Dimova, Povilas Ignatavicius, Peter Koiva, Anne K Penttila, Lucas Ilzarbe, Sara Regner, Jonas Rosendahl, Thomas L Bollen
OBJECTIVE: The most common aetiologies of acute pancreatitis (AP) are gallstones, alcohol and idiopathic. The impact of the aetiology of AP on the extent and morphology of pancreatic and extrapancreatic necrosis (EXPN) has not been clearly established. The aim of the present study was to assess the influence of aetiology on the presence and location of pancreatic necrosis in patients with AP. PATIENTS AND METHODS: We carried out a post-hoc analysis of a previously established multicentre cohort of patients with AP in whom a computed tomography was available for review...
December 26, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29279089/neospora-caninum-bioassay-in-gerbils-using-placental-tissues-from-naturally-infected-goats
#13
R C Costa, L P Mesquita, M V L Nunes, I M Oliveira, L F S Oliveira, Alinne R Souza, P C Maiorka, M S Varaschin
Neospora caninum is one of the main agents that causes abortions in cattle worldwide. However, little is known about the pathogenesis of neosporosis in small ruminants, especially goats. Gerbils (Meriones unguiculatus) have been used as a model for neosporosis, and this species is highly susceptible to infection by bovine N. caninum strains. The present study aimed to evaluate the susceptibility of gerbils to a N. caninum isolate from goats. The placentas were obtained from naturally infected goats, that presented with mild to severe lymphoplasmacytic and histiocytic infiltrate, foci of necrosis, calcification and protozoan-like structures...
January 15, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29278689/trail-induces-apoptosis-but-not-necroptosis-in-colorectal-and-pancreatic-cancer-cells-preferentially-via-the-trail-r2-dr5-receptor
#14
Zuzana Nahacka, Jan Svadlenka, Martin Peterka, Marie Ksandrova, Simona Benesova, Jiri Neuzil, Ladislav Andera
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a cytokine that can trigger apoptosis in many types of human cancer cells via engagement of its two pro-apoptotic receptors TRAIL-R1 (DR4) and TRAIL-R2 (DR5). TRAIL can also activate several other signaling pathways such as activation of stress kinases, canonical NF-κB signaling and necroptosis. Though both receptors are ubiquitously expressed, their relative participation in TRAIL-induced signaling is still largely unknown. To analyze TRAIL receptor-specific signaling, we prepared Strep-tagged, trimerized variants of recombinant human TRAIL with high affinity for either DR4 or DR5 receptor...
December 23, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29274924/vp2-pta-motif-encoding-dna-vaccine-confers-protection-against-lethal-challenge-with-infectious-pancreatic-necrosis-virus-ipnv-in-trout
#15
Sohrab Ahmadivand, Mehdi Soltani, Mahdi Behdani, Øystein Evensen, Ehsan Alirahimi, Elahe Soltani, Reza Hassanzadeh, Javad Ashrafi-Helan
IPNV in Atlantic salmon is represented by various strains with different virulence and immunogenicity linked to various motifs of the VP2 capsid. IPNV variant with P217, T221, A247 (PTA) motif is found to be avirulent in Atlantic salmon, but virulent in rainbow trout, and other salmonid species. This study describes a DNA vaccine delivered intramuscularly encoding the VP2 protein of infectious pancreatic necrosis virus (IPNV) with PTA motif that confers high protection in rainbow trout (Oncorhynchus mykiss)...
December 21, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/29260533/-effect-of-proton-pump-inhibitors-on-severe-acute-pancreatitis-a-prospective-randomized-trial
#16
Xiao Ma, Cheng-Wei Tang, Zhi-Yin Huang, Ming-Guang Zhang, Fang Liu, Chun-Hui Wang, Rui Wang, Huan Tong, Ling Liu
OBJECTIVE: To evaluate the effect of proton pump inhibitors (PPIs) therapy on severe acute pancreatitis (SAP) patients. METHODS: Forty five patients with SAP recruited in our center from October 2015 to October 2016,were randomly assigned into two groups: convention group (C group,n=21) and convention+esomeprazole group (C+E group,n=24). C+E group received esomeprazole 40 mg/d intravenously for 1 week,whereas C group only received baseline treatment. Serum C-reactive protein (CRP),interleukin-6 (IL-6) and interleukin-8 (IL-8),tumor necrosis factor-α (TNF-α) and procalcitonin (PCT) were detected by ELISA on the first day (baseline) and the seventh day...
November 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/29251273/a-retrospective-study-evaluating-endoscopic-ultrasound-guided-drainage-of-pancreatic-fluid-collections-using-a-novel-lumen-apposing-metal-stent-on-an-electrocautery-enhanced-delivery-system
#17
Douglas G Adler, Linda Jo Taylor, Raza Hasan, Ali A Siddiqui
OBJECTIVES: To report the safety and clinical efficacy with the novel lumen-apposing metal stent (LAMS) with an electrocautery enhanced delivery system for the drainage of pancreatic fluid collections (PFCs). METHODS: This was a retrospective analysis of all consecutive patients with PFCs who underwent endoscopic ultrasound (EUS)-guided drainage using the LAMS with an electrocautery enhanced delivery system in 2 US centers. RESULTS: Thirteen patients with PFCs (69% with walled-off necrosis [WON]) underwent drainage using the study device...
November 2017: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/29251115/nano-encapsulation-of-bilirubin-in-pluronic-f127-chitosan-improves-uptake-in-%C3%AE-cells-and-increases-islet-viability-and-function-after-hypoxic-stress
#18
Bronwyn Fullagar, Wei Rao, Chen Gilor, Feng Xu, Xiaoming He, Christopher A Adin
Pancreatic islet transplantation is the only curative, noninvasive treatment for type 1 diabetes mellitus; however, high rates of cell death in the immediate postimplantation period have limited the success of this procedure. Bilirubin, an endogenous antioxidant, can improve the survival of murine pancreatic allografts during hypoxic stress but has poor solubility in aqueous solutions. We hypothesized that nano-encapsulation of bilirubin in pluronic 127-chitosan nanoparticle bilirubin (nBR) would improve uptake by murine pancreatic islet cells and improve their viability following hypoxic stress...
October 2017: Cell Transplantation
https://www.readbyqxmd.com/read/29250586/endoscopic-ultrasound-guided-placement-of-plastic-pigtail-stents-for-the-drainage-of-refractory-malignant-ascites
#19
Rafael Romero-Castro, Victoria Alejandra Jimenez-Garcia, Jaime Boceta-Osuna, Luis Castilla-Guerra, Francisco Pellicer-Bautista, Angel Caunedo-Alvarez, Juan Manuel Herrerias-Gutierrez, Manuel Romero-Gómez, Marc Giovannini
Endoscopic ultrasound (EUS)-guided drainage is now the treatment of choice in cases of pancreatic pseudocysts and walled-off necrosis, especially in the absence of luminal bulging and in patients with portal hypertension. Malignant refractory ascites usually heralds a poor prognosis and substantially impairs the quality of life of patients because of the symptoms experienced and the need for repeated paracentesis. EUS-guided placement of lumen-apposing, fully covered, self-expandable metal stents (FCSEMS) has been reported for the drainage of malignant ascites...
November 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/29235373/pro-inflammatory-cytokine-induced-lipolysis-after-an-episode-of-acute-pancreatitis
#20
Sayali A Pendharkar, Ruma G Singh, Maxim S Petrov
CONTEXT: Pro-inflammatory cytokine-stimulated lipolysis is one of the mechanisms underlying the pathogenesis of type 2 diabetes. However, whether it plays a role in the pathogenesis of post-pancreatitis diabetes mellitus (PPDM) remains unknown. OBJECTIVE: To investigate the associations between markers of lipid metabolism and pro-inflammatory cytokines in individuals after acute pancreatitis (AP) in general, and in individuals with abnormal glucose metabolism (AGM) following AP in particular...
December 13, 2017: Archives of Physiology and Biochemistry
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