keyword
https://read.qxmd.com/read/38534357/differentiation-of-adipose-tissue-mesenchymal-stem-cells-into-endothelial-cells-depends-on-fat-depot-conditions-regulation-by-mirna
#1
JOURNAL ARTICLE
Gemma Arderiu, Anna Civit-Urgell, Alberto Díez-Caballero, Fabrizio Moscatiello, Carlos Ballesta, Lina Badimon
The development of obesity is associated with substantial modulation of adipose tissue (AT) structure. The plasticity of the AT is reflected by its remarkable ability to expand or reduce in size throughout the adult lifespan, which is linked to the development of its vasculature. This increase in AT vasculature could be mediated by the differentiation of adipose tissue-derived stem cells (ASCs) into endothelial cells (ECs) and form new microvasculature. We have already shown that microRNA (miRNA)-145 regulates the differentiation of ASCs into EC-like (ECL) cells...
March 14, 2024: Cells
https://read.qxmd.com/read/38524743/the-frequency-of-nras-mutation-in-stool-samples-of-iranian-colorectal-cancers-compared-to-finnish-patients
#2
JOURNAL ARTICLE
Farideh Saberi, Omar Youssef, Arto Kokkola, Mahsa Khodadoostan, Pauli Puolakkainen, Rasoul Salehi, Sakari Knuutila
BACKGROUND: Stools from colorectal cancer patients are noninvasive samples that could be used to compare the frequency of hotspot mutations between two different ethnic cohorts. MATERIALS AND METHODS: We collected stool samples from the Iranian cohort (52 patients and 49 controls) and the Finnish cohort (40 patients and 14 controls). Following stool DNA extraction, we used the AmpliSeq Colon and Lung Cancer panel to prepare DNA libraries before sequencing. RESULTS: The Iranian cohort exhibited 35 hotspot mutations in the BRAF , ERBB4 , FBXW7 , FGFR1 , FGFR3 , KRAS , MAP2K , MET , NRAS , PIK3C , SMAD4 , and TP53 genes...
2024: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://read.qxmd.com/read/38524483/protac-design-evaluator-prode-an-advanced-method-for-in-silico-protac-design
#3
JOURNAL ARTICLE
Ben Geoffrey A S, Deepak Agrawal, Nagaraj M Kulkarni, Rajappan Vetrivel, Kishan Gurram
PROTAC (proteolysis-targeting chimeras) is a rapidly evolving technology to target undruggable targets. The mechanism by which this happens is when a bifunctional molecule binds to a target protein and also brings an E3 ubiquitin ligase in proximity to trigger ubiquitination and degradation of the target protein. Yet, in-silico-driven approaches to design these heterobifunctional molecules that have the desired functional properties to induce proximity between the target protein and E3 ligase remain to be established...
March 19, 2024: ACS Omega
https://read.qxmd.com/read/38522181/if-it-s-a-target-it-s-a-pan-cancer-target-tissue-is-not-the-issue
#4
REVIEW
Jacob J Adashek, Shumei Kato, Jason K Sicklick, Scott M Lippman, Razelle Kurzrock
Cancer is traditionally diagnosed and treated on the basis of its organ of origin (e.g., lung or colon cancer). However, organ-of-origin diagnostics does not reveal the underlying oncogenic drivers. Fortunately, molecular diagnostics have advanced at a breathtaking pace, and it is increasingly apparent that cancer is a disease of the genome. Hence, we now have multiple genomic biomarker-based, tissue-agnostic Food and Drug Administration approvals for both gene- and immune-targeted therapies (larotrectinib/entrectinib, for NTRK fusions; selpercatinib, RET fusions; dabrafenib plus trametinib, BRAFV600E mutations; pembrolizumab/dostarlimab, microsatellite instability; and pembrolizumab for high tumor mutational burden; pemigatinib is also approved for FGFR1-rearranged myeloid/lymphoid neoplasms)...
March 21, 2024: Cancer Treatment Reviews
https://read.qxmd.com/read/38512553/correction-resistance-to-fgfr1-targeted-therapy-leads-to-autophagy-via-tak1-ampk-activation-in-gastric-cancer
#5
Rui Peng, Yan Chen, Liangnian Wei, Gang Li, Dongju Feng, Siru Liu, Runqiu Jiang, Shaojiang Zheng, Yun Chen
No abstract text is available yet for this article.
March 21, 2024: Gastric Cancer
https://read.qxmd.com/read/38496900/the-occurrence-and-development-of-abdominal-aortic-aneurysm-may-be-related-to-the-energy-metabolism-disorder-and-local-inflammation
#6
JOURNAL ARTICLE
Jun Li, Yang Liu, Zhitao Wei, Jie Cheng, Yongfa Wu
BACKGROUND: The cellular mechanism of the formation of abdominal aortic aneurysm (AAA) is very complicated. A series of sophisticated events eventually led to significant pathological changes in the anatomical structure and function of the arterial wall and they are still not clear nowadays. METHODS: We pooled publicly available GEO datasets (GSE57691 and GSE47472) to get a comprehensive comparisons between normal tissues and AAA tissues to try to reveal molecular mechanism underlying the disease...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38496689/high-resolution-genomic-configuration-of-fgfr-rearrangements-dictates-the-therapeutic-vulnerability-of-squamous-cell-lung-cancers
#7
EDITORIAL
Sook-Hee Hong, Tae-Min Kim
No abstract text is available yet for this article.
February 29, 2024: Translational Lung Cancer Research
https://read.qxmd.com/read/38496361/ectopic-hcn4-provides-a-target-biomarker-for-the-genetic-spectrum-of-mtoropathies
#8
JOURNAL ARTICLE
Matthew Coleman, Paulo Pinares-Garcia, Sarah E Stephenson, Wei Shern Lee, Daniz Kooshavar, Catriona A Mclean, Katherine B Howell, Richard J Leventer, Christopher A Reid, Paul J Lockhart
BACKGROUND AND OBJECTIVES: Pathogenic variants in PI3K-AKT-mTOR pathway and GATOR1 complex genes resulting in hyperactivation of mechanistic target of rapamycin (mTOR) complex 1 are a major cause of drug-resistant epilepsy and focal cortical malformations (FCM). Resective neurosurgery is often required to achieve seizure control in patients with mTORopathies due to lack of effectiveness of nonsurgical therapies, including antiseizure medication and mTOR inhibitors. Elevated hyperpolarization-activated cyclic nucleotide-gated potassium channel isoform 4 (HCN4) has been proposed as a key marker in some mTOR-related brain malformations...
April 2024: Neurology. Genetics
https://read.qxmd.com/read/38481600/patient-sex-and-origin-influence-distribution-of-driver-genes-and-clinical-presentation-of-paraganglioma
#9
JOURNAL ARTICLE
Susan Richter, Nicole Bechmann
CONTEXT: Sexual and ancestral differences in driver gene prevalence have been described in many cancers but have not yet been investigated in pheochromocytoma and paraganglioma (PPGL). OBJECTIVE: This study aims to assess whether sex and ancestry influence prevalence of PPGL driver genes and clinical presentation. METHODS: We conducted a retrospective analysis of patients with PPGL considering studies from 2010 onwards that included minimal data of type of disease, sex, mutated gene, and country of origin...
March 12, 2024: Journal of the Endocrine Society
https://read.qxmd.com/read/38479160/cancer-associated-fibroblasts-promote-gastric-cancer-cell-proliferation-by-paracrine-fgf2-driven-ribosome-biogenesis
#10
JOURNAL ARTICLE
Dandan Li, Pan Huang, Lingyun Xia, Weidong Leng, Shanshan Qin
The cancer-associated fibroblast (CAF)-derived secretome plays critical roles in tumor progression by remodelling tumor microenvironment. Tumorigenesis is accompanied by the transformation of normal fibroblasts (NF) into CAF, leading to significant changes in their secretome. This work aims to identify the differential components of secretome between NFs and CAFs and reveal their functions in gastric cancer (GC). Firstly, our molecular typing studies and immune infiltration analysis showed that CAF infiltration level was increased and showed a significant association with clinical characteristics and poor prognosis of GC patients...
March 12, 2024: International Immunopharmacology
https://read.qxmd.com/read/38477013/mir-2110-induced-by-chemically-synthesized-cinobufagin-functions-as-a-tumor-metastatic-suppressor-via-targeting-fgfr1-to-reduce-pten-ubiquitination-degradation-in-nasopharyngeal-carcinoma
#11
JOURNAL ARTICLE
Shiyi Fang, Lanzhu Peng, Mengmin Zhang, Rentao Hou, Xing Deng, Xiaoning Li, Jianyang Xin, Lingrong Peng, Zhihua Liu, Yiyi Liu, Yingying Xie, Beixian Zhou, Weiyi Fang, Zhen Liu, Chao Cheng
Tumor cell metastasis is the key cause of death in patients with nasopharyngeal carcinoma (NPC). MiR-2110 was cloned and identified in Epstein-Barr virus (EBV)-positive NPC, but its role is unclear in NPC. In this study, we investigated the effect of miR-2110 on NPC metastasis and its related molecular basis. In addition, we also explored whether miR-2110 can be regulated by cinobufotalin (CB) and participate in the inhibition of CB on NPC metastasis. Bioinformatics, RT-PCR, and in situ hybridization were used to observe the expression of miR-2110 in NPC tissues and cells...
March 13, 2024: Environmental Toxicology
https://read.qxmd.com/read/38473737/real-world-data-and-clinical-implications-of-next-generation-sequencing-ngs-based-analysis-in-metastatic-breast-cancer-patients
#12
JOURNAL ARTICLE
Fabio Canino, Antonio Tornincasa, Stefania Bettelli, Samantha Manfredini, Monica Barbolini, Luca Moscetti, Claudia Omarini, Angela Toss, Fabio Tamburrano, Giuseppina Antonelli, Federica Baglio, Lorenzo Belluzzi, Giulio Martinelli, Salvatore Natalizio, Ornella Ponzoni, Massimo Dominici, Federico Piacentini
Over the last two decades, the use of Next-Generation Sequencing (NGS) in medical oncology has increased the likelihood of identifying druggable mutations that may be potentially susceptible to targeted treatments. The European Society for Medical Oncology (ESMO) currently does not recommend the use of the NGS test to determine the therapeutic course of patients with metastatic breast cancer (mBC) in daily clinical practice. However, the aim of this work is to evaluate the potential contribution of the NGS test in selecting targeted therapies for patients with mBC...
February 20, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38468162/the-relationship-between-primary-ovarian-insufficiency-and-gene-variations-a-prospective-case-control-study
#13
JOURNAL ARTICLE
Reyhan Gündüz, Selahaddin Tekeş, Lütfiye Ozpak, Elif Ağaçayak, Senem Yaman Tunç, Mehmet Sait İcen, Mehmet Sıddık Evsen
Around 70 percent of cases of Primary Ovarian Insufficiency (POI) etiology remain unexplained. The aim of our study is to contribute to the etiology and genetic background of POI. A total of 37 POI patients and 30 women in the reproductive period were included in this prospective, case-control study between August 2020 and December 2021. The women were examined for 36 genes with next-generation sequencing (NGS) panel. Gene variations were detected in 59.5 percent of the patients in the case group. FSHR p.S680N (rs6166, c...
March 11, 2024: Women & Health
https://read.qxmd.com/read/38460250/comprehensive-genomic-profiling-to-identify-actionable-alterations-for-breast-cancer-brain-metastases-in-the-chinese-population
#14
JOURNAL ARTICLE
Q Lu, N Wang, K Jiang, H Zhou, P Zhang, J Zhang, S Wang, P Sun, F Xu
BACKGROUND: Breast cancer brain metastasis (BCBM) is a crucial issue in the treatment of breast cancer and is associated with poor prognosis. Therefore, novel therapeutic targets are urgently needed in clinical practice. In this study, we aimed to identify potential actionable targets in brain metastases (BMs) utilising the FoundationOne® CDx (F1CDx). PATIENTS AND METHODS: Formalin-fixed paraffin-embedded archived specimens including 16 primary breast tumours (PTs), 49 BCBMs and 7 extracranial metastases (ECMs) from 54 patients who underwent surgery for BCBM were tested using F1CDx...
March 8, 2024: ESMO Open
https://read.qxmd.com/read/38457113/prevalence-of-chromosome-8p11-2-translocations-and-correlation-with-myeloid-and-lymphoid-neoplasms-associated-with-fgfr1-abnormalities-in-a-consecutive-cohort-from-nine-institutions-in-japan
#15
JOURNAL ARTICLE
Kensuke Usuki, Takuro Kameda, Noriaki Kawano, Tomoki Ito, Yoshinori Hashimoto, Kotaro Shide, Hiroshi Kawano, Masaaki Sekine, Takanori Toyama, Hiromitsu Iizuka, Seiichi Sato, Masanori Takeuchi, Junzo Ishizaki, Kouichi Maeda, Michikazu Nakai, Kiyoshi Yamashita, Yoko Kubuki, Kazuya Shimoda
Myeloid and lymphoid neoplasms associated with FGFR1 abnormalities (MLN-FGFR1 abnormalities) are rare hematologic malignancies associated with chromosome 8p11.2 abnormalities. Translocations of 8p11.2 were detected in 10 of 17,039 (0.06%) unique patient cytogenetic studies performed at nine institutions in Japan. No inversions or insertions of 8p11.2 were detected. Among the 10 patients with 8p11.2 translocations, three patients were diagnosed with MLN-FGFR1 abnormalities, which were confirmed by FISH analysis...
March 8, 2024: International Journal of Hematology
https://read.qxmd.com/read/38448735/dna-functionalized-artificial-mechanoreceptor-for-de-novo-force-responsive-signaling
#16
JOURNAL ARTICLE
Sihui Yang, Miao Wang, Dawei Tian, Xiaoyu Zhang, Kaiqing Cui, Shouqin Lü, Hong-Hui Wang, Mian Long, Zhou Nie
Synthetic signaling receptors enable programmable cellular responses coupling with customized inputs. However, engineering a designer force-sensing receptor to rewire mechanotransduction remains largely unexplored. Herein, we introduce nongenetically engineered artificial mechanoreceptors (AMRs) capable of reprogramming non-mechanoresponsive receptor tyrosine kinases (RTKs) to sense user-defined force cues, enabling de novo-designed mechanotransduction. AMR is a modular DNA-protein chimera comprising a mechanosensing-and-transmitting DNA nanodevice grafted on natural RTKs via aptameric anchors...
March 6, 2024: Nature Chemical Biology
https://read.qxmd.com/read/38443583/transcriptomic-screening-of-novel-targets-of-sericin-in-human-hepatocellular-carcinoma-cells
#17
JOURNAL ARTICLE
Jiraporn Jantaravinid, Napatara Tirawanchai, Sumate Ampawong, Kanchana Kengkoom, Anchaleekorn Somkasetrin, Vorthunju Nakhonsri, Pornanong Aramwit
Sericin, a natural protein derived from Bombyx mori, is known to ameliorate liver tissue damage; however, its molecular mechanism remains unclear. Herein, we aimed to identify the possible novel targets of sericin in hepatocytes and related cellular pathways. RNA sequencing analysis indicated that a low dose of sericin resulted in 18 differentially expressed genes (DEGs) being upregulated and 68 DEGs being downregulated, while 61 DEGs were upregulated and 265 DEGs were downregulated in response to a high dose of sericin (FDR ≤ 0...
March 5, 2024: Scientific Reports
https://read.qxmd.com/read/38440574/literature-review-case-presentation-and-management-of-non-ossifying-fibroma-of-right-angle-of-mandible-more-than-just-a-cortical-defect
#18
JOURNAL ARTICLE
Deepak Pandiar, P Anbumani, Reshma Poothakulath Krishnan
Non-ossifying fibroma (NOF) of jaw bones are rare. While NOF is the most common benign bone tumor of long bones with pathognomonic radiological features and bear a tendency for self-regression, gnathic NOF appears to be comparatively larger in size and behave more aggressively. A 16 years old female patient reported with painless swelling of the right side of the face of 4 months duration. Radiographic analysis showed a unilocular radiolucent lesion of right angle of the mandible with ill-defined margins, cortical perforation and thinning of inferior border...
February 2024: Indian Journal of Otolaryngology and Head and Neck Surgery
https://read.qxmd.com/read/38437671/the-irreversible-fgfr-inhibitor-kin-3248-overcomes-fgfr2-kinase-domain-mutations
#19
JOURNAL ARTICLE
Eranga R Balasooriya, Qibiao Wu, Haley Ellis, Yuanli Zhen, Bryanna L Norden, Ryan B Corcoran, Adithi Mohan, Eric Martin, Aleksandra Franovic, John Tyhonas, Matthew Lardy, Kathryn B Grandinetti, Robert Pelham, Liliana Soroceanu, Vanessa S Silveira, Nabeel Bardeesy
PURPOSE: FGFR2 and FGFR3 show oncogenic activation in many cancer types, often through chromosomal fusion or extracellular domain mutation. FGFR2 and FGFR3 alterations are most prevalent in intrahepatic cholangiocarcinoma (ICC) and bladder cancers, respectively, and multiple selective reversible and covalent pan-FGFR tyrosine kinase inhibitors (TKIs) have been approved in these contexts. However, resistance, often due to acquired secondary mutations in the FGFR2/3 kinase domain, limits efficacy...
March 4, 2024: Clinical Cancer Research
https://read.qxmd.com/read/38432058/design-synthesis-and-biological-evaluation-of-selective-covalent-inhibitors-of-fgfr4
#20
JOURNAL ARTICLE
Xiaojuan Chen, Huiliang Li, Qianmeng Lin, Shuyan Dai, Lingzhi Qu, Ming Guo, Lin Zhang, Jiaxuan Liao, Hudie Wei, Guangyu Xu, Longying Jiang, Yongheng Chen
Aberrant signaling via fibroblast growth factor 19 (FGF19)/fibroblast growth factor receptor 4 (FGFR4) has been identified as a driver of tumorigenesis and the development of many solid tumors, making FGFR4 is a promising target for anticancer therapy. Herein, we designed and synthesized a series of bis-acrylamide covalent FGFR4 inhibitors and evaluated their inhibitory activity against FGFRs, FGFR4 mutants, and their antitumor activity. CXF-007, verified by mass spectrometry and crystal structures to form covalent bonds with Cys552 of FGFR4 and Cys488 of FGFR1, exhibited stronger selectivity and potent inhibitory activity for FGFR4 and FGFR4 cysteine mutants...
February 28, 2024: European Journal of Medicinal Chemistry
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