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https://www.readbyqxmd.com/read/29915512/the-study-of-effect-of-didecyl-dimethyl-ammonium-bromide-on-bacterial-and-viral-decontamination-for-biosecurity-in-the-animal-farm
#1
Tippawan Jantafong, Sakchai Ruenphet, Darsaniya Punyadarsaniya, Kazuaki Takehara
Aim: The aim of this study was to determine the effectiveness of the fourth-generation quaternary ammonium compounds, didecyl dimethyl ammonium bromide (DDAB), on the efficacy of bacterial and viral decontamination against pathogens commonly found in livestock industry including Salmonella infantis (SI), Escherichia coli , and avian influenza virus (AIV). Materials and Methods: The DDAB was prepared at 500, 250, and 125 parts per million (ppm) for absent and present organic material...
May 2018: Veterinary World
https://www.readbyqxmd.com/read/29910688/recalling-cohnheim-s-theory-papillary-renal-cell-tumor-as-a-model-of-tumorigenesis-from-impaired-embryonal-differentiation-to-malignant-tumors-in-adults
#2
Daniel Banyai, Donat P Sarlos, Anetta Nagy, Gyula Kovacs
We have suggested that papillary renal cell tumor (PRCT) of the kidney arises from nephrogenic rest-like lesions. To approve our hypothesis, we worked up 14 kidneys bearing papillary and 14 ones with conventional renal cell carcinoma (CRCC) histologically and found 42 papillary lesions in average per kidney bearing PRCT. PRCTs are characterized by loss of the Y chromosome and trisomy of chromosomes 7 and 17. The MET and HNF1B are localized to chromosome 7q31 and 17q21 and are frequently amplified in PRCT. We have analyzed the expression of the mutant MET in hereditary PRCTs and precursor lesions and found duplication and expression of the mutated allele...
2018: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/29906703/modulation-of-serum-albumin-protein-corona-for-exploring-cellular-behaviors-of-fattigation-platform-nanoparticles
#3
Van Hong Nguyen, Nilesh M Meghani, Hardik H Amin, Thao T D Tran, Phuong H L Tran, Chulhun Park, Beom-Jin Lee
Albumin is the most abundant protein in blood, and is the most frequently identified protein in the protein corona of nanoparticles (NPs). Thus, albumin plays an important role in modulating NPs' physicochemical properties and bioavailability. In this study, the effect of bovine serum albumin (BSA) on gelatin-oleic nanoparticles' (GONs) physicochemical properties and cellular uptake were evaluated. Coumarin-6 was used as indicator to track the cellular uptake of GONs. The binding of BSA onto the GON surface increased the size, slightly reduced the negative net charge of the GON, and improved GON stability...
May 28, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29896480/use-of-antihypertensive-drugs-during-preeclampsia
#4
Obinnaya Odigboegwu, Lu J Pan, Piyali Chatterjee
Treatment of pregnancy-related hypertensive disorders, such as preeclampsia (PE), remain a challenging problem in obstetrics. Typically, aggressive antihypertensive drug treatment options are avoided to prevent pharmacological-induced hypotension. Another major concern of administering antihypertensive drugs during pregnancy is possible adverse fetal outcome. In addition, management of hypertension during pregnancy in chronic hypertensive patients or in patients with prior kidney problems are carefully considered...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29892489/influence-of-postnatal-hydroureter-in-determining-the-need-for-voiding-cystourethrogram-in-children-with-high-grade-hydronephrosis
#5
Amr Hodhod, John-Paul Capolicchio, Roman Jednak, Eid El-Sherif, Abd El-Alim El-Doray, Mohamed El-Sherbiny
Objective: To evaluate the utility of hydroureter (HU) to identify high-grade vesico-ureteric reflux (VUR) in patients with high-grade postnatal hydronephrosis (PH). Patients and methods: We retrospectively reviewed patients' charts that had antenatal hydronephrosis from 2008 to 2014. Patients were excluded if they presented with febrile urinary tract infection (fUTI), neurogenic bladder, posterior urethral valve, multi-cystic dysplastic kidney, and multiple congenital malformations...
June 2018: Arab Journal of Urology
https://www.readbyqxmd.com/read/29884919/preeclampsia-risks-in-kidney-donors-and-recipients
#6
REVIEW
Pratik B Shah, Manpreet Samra, Michelle A Josephson
PURPOSE OF REVIEW: To review the studies and practice guidelines on the preeclampsia risks in kidney donors and recipients. RECENT FINDINGS: There is a small increased risk of gestational hypertension and preeclampsia in pregnancies that follow kidney donation. Kidney Disease Improving Global Outcomes (KDIGO) Clinical Practice Guideline (2017) and the 2015 American Society of Transplantation (AST) consensus conference statement recommends counseling kidney donors about this increased risk...
June 8, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29880371/long-term-effects-of-pregnancy-on-renal-graft-function-in-women-after-kidney-transplantation-compared-with-matched-controls
#7
S Svetitsky, R Baruch, I F Schwartz, D Schwartz, R Nakache, Y Goykhman, P Katz, A Grupper
BACKGROUND: An important benefit associated with kidney transplantation in women of child-bearing age is increased fertility. We retrospectively evaluated the maternal and fetal complications and evolution of graft function associated with 22 pregnancies post-kidney and kidney-pancreas transplantation, compared with controls without pregnancy post-transplantation, who were matched for gender, year of transplantation, type of donor, age at transplantation, number of transplants, type of transplant (kidney vs kidney-pancreas), and cause of native kidney failure, as well as for renal parameters including serum creatinine and urine protein excretion 1 year before delivery...
June 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29879071/long-term-outcomes-of-kidney-and-bladder-function-in-patients-with-a-posterior-urethral-valve
#8
Sung Jin Kim, Jaeyoon Jung, Chanwoo Lee, Sejun Park, Sang Hoon Song, Hye-Sung Won, Kun Suk Kim
We investigated long-term functional changes in the kidney and bladder of patients with posterior urethral valve (PUV) who underwent fetal intervention or postnatal surgery.We retrospectively reviewed the medical records of 28 consecutive patients treated for PUV at our institution. Detailed data on medical and surgical histories, particularly on pre- and postnatal treatment modality, including fetal vesicoamniotic shunt, endoscopic valve ablation, and vesicostomy, were collected and analyzed. Long-term renal function was evaluated based on serum levels of creatinine (sCr), estimated glomerular filtration rate (eGFR), and renal scans...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29869628/the-effect-of-prenatal-exposure-on-disposition-of-hexachloronaphthalene-in-female-wistar-rats-and-fetal-compartment
#9
Joanna Stragierowicz, Krystyna Sitarek, Bartłomiej Grobelski, Anna Kilanowicz-Sapota
OBJECTIVES: Due to structural and toxicological similarities to 2,3,7,8-tetrachlorodibenzo-<i>p</i>-dioxin (TCDD), polychlorinated naphthalenes (PCNs) were included in the Stockholm Convention on Persistent Organic Pollutants (POPs) in 2015. Hexachloronaphthalene (HxCN) is considered to be one of the most toxic congeners of PCNs. The objective of this study was to determine the maternal and fetal tissue concentrations of hexachloronaphthalene after a single administration...
June 4, 2018: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/29867903/placental-inflammation-and-fetal-injury-in-a-rare-zika-case-associated-with-guillain-barr%C3%A3-syndrome-and-abortion
#10
Kíssila Rabelo, Luiz J Souza, Natália G Salomão, Edson R A Oliveira, Lynna de Paula Sentinelli, Marcelle S Lacerda, Pedro B Saraquino, Fernando C Rosman, Rodrigo Basílio-de-Oliveira, Jorge J Carvalho, Marciano V Paes
Zika virus (ZIKV) is an emerging virus involved in recent outbreaks in Brazil. The association between the virus and Guillain-Barré syndrome (GBS) or congenital disorders has raised a worldwide concern. In this work, we investigated a rare Zika case, which was associated with GBS and spontaneous retained abortion. Using specific anti-ZIKV staining, the virus was identified in placenta (mainly in Hofbauer cells) and in several fetal tissues, such as brain, lungs, kidneys, skin and liver. Histological analyses of the placenta and fetal organs revealed different types of tissue abnormalities, which included inflammation, hemorrhage, edema and necrosis in placenta, as well as tissue disorganization in the fetus...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29859996/transgenerational-programming-of-nephron-deficits-and-hypertension
#11
REVIEW
Jessica F Briffa, Mary E Wlodek, Karen M Moritz
Exposure to a sub-optimal environment in the womb can result in poor fetal growth and impair the normal development of organs. The kidney, specifically the process of nephrogenesis, has been shown to be impacted by many common pregnancy exposures including an inadequate diet, poor placental function, maternal stress as well as maternal smoking and alcohol consumption. This can result in offspring being born with a reduced nephron endowment, which places these individuals at increased risk of hypertension and chronic kidney disease (CKD)...
May 31, 2018: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/29804258/maternal-eating-behavior-is-a-major-synchronizer-of-fetal-and-postnatal-peripheral-clocks-in-mice
#12
Laurence Canaple, Aline Gréchez-Cassiau, Franck Delaunay, Ouria Dkhissi-Benyahya, Jacques Samarut
Most living organisms show circadian rhythms in physiology and behavior. These oscillations are generated by endogenous circadian clocks, present in virtually all cells where they control key biological processes. To study peripheral clocks in vivo, we developed an original model, the Rev-Luc mouse to follow noninvasively and longitudinally Rev-Luc oscillations in peripheral clocks using in vivo bioluminescence imaging. We found in vitro and in vivo a robust diurnal rhythm of Rev-Luc, mainly in liver, intestine, kidney and adipose tissues...
May 26, 2018: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/29796227/effect-of-maternal-fluoxetine-exposure-on-lung-heart-and-kidney-development-in-rat-neonates
#13
Razieh Taghizadeh Ghavamabadi, Zahra Taghipour, Mahsa Hassanipour, Marzieh Khademi, Mehdi Shariati
Objectives: Depression during pregnancy negatively affects fetal development. Fluoxetine as a selective serotonin reuptake inhibitor (SSRIs) is used for treatment of gestational depression. This study is trying to determine the effects of fluoxetine on the renal, heart and lung development. Materials and Methods: Fifteen pregnant rats were treated with fluoxetine at 7 mg/kg from days 0 to 21 of gestation. Immediately after born, heart and kidney samples were evaluated for genes expression and histological assessment...
April 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29795211/incidence-of-neonatal-hypertension-from-a-large-multicenter-study-assessment-of-worldwide-acute-kidney-injury-epidemiology-in-neonates-awaken
#14
Emily J Kraut, Louis J Boohaker, David J Askenazi, Jeffery Fletcher, Alison L Kent
BACKGROUND: Hypertension occurs in up to 3% of neonates admitted to the Neonatal Intensive Care Unit (NICU), and is a potentially under-recognized condition. The aim of this study was to examine the incidence of documented and undiagnosed hypertension from the 24-center Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates (AWAKEN) database, and to assess risk factors for hypertension according to gestational age. METHODS: Diagnosed hypertension was documented if an infant had a discharge diagnosis of hypertension and/or discharged on antihypertensive medications...
May 23, 2018: Pediatric Research
https://www.readbyqxmd.com/read/29789348/gestational-low-protein-intake-enhances-whole-kidney-mir-192-and-mir-200-family-expression-and-epithelial-to-mesenchymal-transition-in-rat-adult-male-offspring
#15
Letícia B Sene, Victor Hugo Gonçalves Rizzi, José A R Gontijo, Patricia A Boer
Studies have shown that adult offspring of mothers fed a protein-restricted diet during pregnancy present a pronounced reduction of nephron number associated with decreased fractional urinary sodium excretion and arterial hypertension. Additionally, recent advances in our understanding of the molecular pathways that govern the association of gestational nutritional restriction, intrauterine growth retardation and inflammation with impaired nephrogenesis, nephron underdosing and kidney fibrosis point to the epithelial to mesenchymal transition (EMT) as a common factor...
May 22, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29777040/obe022-an-oral-and-selective-prostaglandin-f2%C3%AE-receptor-antagonist-as-an-effective-and-safe-modality-for-the-treatment-of-preterm-labor
#16
Oliver Pohl, Andre Chollet, Sung Hye Kim, Lucia Riaposova, Francois Spezia, Frederic Gervais, Philippe Guillaume, Philippe Lluel, Murielle Meen, Frederique Lemaux, Vasso Terzidou, Phillip R Bennett, Jean-Pierre Gotteland
Preterm birth is the major challenge in obstetrics affecting ~10% of pregnancies. Pan-prostaglandin synthesis inhibitors (NSAID) prevent preterm labor and prolong pregnancy but raise concerns about fetal renal and cardiovascular safety. We conducted preclinical studies examining the tocolytic effect and fetal safety of the oral prodrug candidate OBE022 and its parent OBE002, both potent and highly selective antagonist of the contractile PGF2α prostaglandin receptor (FP). Efficacy of OBE022 and OBE002, alone and in combination with other tocolytics, was assessed in human tissues and pregnant animal models for inhibition of uterine contraction and delay of parturition...
May 18, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29770967/developmental-programming-of-renal-function-nephron-endowment-and-beyond
#17
Andrew G Woodman, Stephane L Bourque
In the face of adversity, the fetal kidney doesn't fare well. When resources are limiting due to pregnancy complications such as placental insufficiency, maternal hypoxia, or nutrient deficiencies, kidney development is often compromised, showing signs of reduced growth, defective nephrogenesis, and abnormal morphology. This article is protected by copyright. All rights reserved.
May 17, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29764249/the-effects-of-acrylamide-and-vitamin-e-on-kidneys-in-pregnancy-an-experimental-study
#18
Mehmet Erman Erdemli, Zeynep Aksungur, Mehmet Gul, Birgul Yigitcan, Harika Gozukara Bag, Eyup Altinoz, Yusuf Turkoz
OBJECTIVES: The objective of this study is to investigate possible damages to kidney tissues of pregnant rats and their fetuses exposed to acrylamide during pregnancy and possible protective effects of vitamin E against these damages. MATERIAL AND METHODS: Rats were randomly assigned to five groups of control, corn oil, vitamin E, acrylamide, vitamin E + acrylamide, six pregnant rats in each. Mother and fetal kidney tissues were examined for malondialdehyde (MDA), reductase glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), total antioxidant status (TAS), total oxidant status (TOS), urea, creatine, trace elements such as Zn and Cu in the serum and histopathological analyses were conducted...
May 15, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29761476/comparison-of-materno-fetal-predictors-and-short-term-outcomes-between-early-and-late-onset-pre-eclampsia-in-the-low-income-setting-of-douala-cameroon
#19
Charlotte Tchente Nguefack, Annabel Ako Mangwi, Anastase Dzudie Tamdja, Théophile Nana Njamen, Paul Nkemtendong Tolefack, Emile Mboudou
OBJECTIVE: To describe and compare materno-fetal predictors and short-term outcomes of early onset pre-eclampsia (EOPE) and late onset pre-eclampsia (LOPE) in Douala, Cameroon. METHODS: The present prospective hospital-based cross-sectional study included women with pre-eclampsia attending obstetric units at four hospitals in Douala between December 1, 2016, and April 30, 2017. To determine maternal predictors, sociodemographic and medical data were recorded using a pretested questionnaire...
May 14, 2018: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29758543/magnesium-sulfate-versus-esomeprazole-impact-on-the-neonates-of-preeclamptic-rats
#20
Amani N Shafik, Mahmoud A Khattab, Ahmed H Osman
OBJECTIVE: Preeclampsia represents a major complication of pregnancy, associated with greater maternal and fetal complications. We compared the effects of esomeprazole (a proton pump inhibitor) and magnesium sulfate (MgSO4) on the deleterious effects observed on the mother and neonates in experimentally induced preeclampsia in rats. STUDY DESIGN: Preeclampsia was induced in pregnant rats with NG-nitro-l-arginine methyl ester (L-NAME) starting from day 10-till end of pregnancy...
June 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
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