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Neuroendocrine tumors

R Siggel, T Schick, R S Grajewski, S Liakopoulos
A 75-year-old female patient presented with bilateral progressive loss of vision. Best corrected visual acuity (BCVA) was hand movements in the right eye and 1/50 in the left eye. The spectral domain optical coherence tomography (SD-OCT) showed thinning of the outer retina suspected to be due to autoimmune retinopathy. A neuroendocrine carcinoma of the uterus was diagnosed during tumor screening. Under systemic therapy with corticosteroids the visual acuity improved to 20/200 in the right eye and 20/80 in the left eye...
June 21, 2018: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
Paola Bettinsoli, Giulia Ferrari-Toninelli, Sara Anna Bonini, Michela Guarienti, Davide Cangelosi, Luigi Varesio, Maurizio Memo
Neuroblastoma is a pediatric tumor of the sympatoadrenal lineage of the neural crest characterized by high molecular and clinical heterogeneity, which are the main causes of the poor response to standard multimodal therapy. The identification of new and selective biomarkers is important to improve our knowledge on the mechanisms of neuroblastoma progression and to find the targets for innovative cancer therapies. This study identifies a positive correlation among tropomodulins (TMODs) proteins expression and neuroblastoma progression...
June 5, 2018: Oncotarget
Hao Wang, Yuejuan Cheng, Jingjing Zhang, Jie Zang, Hui Li, Qingxing Liu, Jingnan Wang, Orit Jacobson, Fang Li, Zhaohui Zhu, Xiaoyuan Chen
Objective: 177 Lu-DOTA-EB-TATE is a theranostic agent based on octreotate that uses an Evans blue structure to bind albumin to improve the pharmacokinetics and pharmacodynamics. This pilot study aims to evaluate the efficacy of a single low-dose treatment using 177 Lu-DOTA-EB-TATE in patients with advanced neuroendocrine neoplasm (NEN). Methods: With IRB approval and informed consent, 4 NEN patients were enrolled to undergo 177 Lu-DOTA-EB-TATE treatment with a single low dose of 0.66 ± 0.06 GBq (17.8 ± 1...
2018: Theranostics
Snider Desir, Patrick O'Hare, Rachel Isaksson Vogel, William Sperduto, Akshat Sarkari, Elizabeth L Dickson, Phillip Wong, Andrew C Nelson, Yuman Fong, Clifford J Steer, Subbaya Subramanian, Emil Lou
Intercellular communication plays a critical role in the ever-evolving landscape of invasive cancers. Recent studies have elucidated the potential role of tunneling nanotubes (TNTs) in this function. TNTs are long, filamentous, actin-based cell protrusions that mediate direct cell-to-cell communication between malignant cells. In this study, we investigated the formation of TNTs in response to variable concentrations of the chemotherapeutic drug doxorubicin, which is used extensively in the treatment of cancer patients...
June 21, 2018: Scientific Reports
Daniela Dettori, Francesca Orso, Elisa Penna, Désirée Baruffaldi, Serena Brundu, Federica Maione, Emilia Turco, Enrico Giraudo, Daniela Taverna
We previously demonstrated that miR-214 is upregulated in malignant melanomas and triple-negative breast tumors and promotes metastatic dissemination by affecting a complex pathway including the anti-metastatic miR-148b. Importantly, tumor dissemination could be reduced by blocking miR-214 function or increasing miR-148b expression or by simultaneous interventions. Based on this evidence, with the intent to explore the role of miR-214 as a target for therapy, we evaluated the capability of new chemically modified anti-miR-214, R97/R98, to inhibit miR-214 coordinated metastatic traits...
June 18, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
Suryakant Niture, Malathi Ramalinga, Habib Kedir, Dorrelyn Patacsil, Samiksha S Niture, James Li, Haresh Mani, Simeng Suy, Sean Collins, Deepak Kumar
Tumor necrosis factor-α-inducible protein 8 (TNFAIP8) is a TNF-α inducible anti-apoptotic protein with multiple roles in tumor growth and survival. Mechanisms of cell survival by TNFAIP8 remain elusive. We investigated the role of TNFAIP8 in the regulation of the cell cycle, autophagy, cell survival and neuroendocrine differentiation in prostate cancer cells. We showed that TNFAIP8 dysregulates cell-cycle-related proteins, in PC3 cells. Oncogenic cell survival, drug resistance and dysregulation of cell cycle-related proteins are often associated with autophagy...
June 1, 2018: Oncotarget
Takashi Tomiyama, Masahiro Orino, Koh Nakamaru, Toshihiro Tanaka, Ryo Suzuki, Takashi Okazaki, Norimasa Fukata, Yugo Ando, Naoyuki Danbara, Toshiro Fukui, Chika Miyasaka, Kazuichi Okazaki
Esophageal large-cell neuroendocrine carcinoma (NEC) is a rare malignant tumor that is characterized by high-grade malignancy and a poor prognosis. However, the rarity of esophageal NEC has prevented the development of an established treatment, and no reports have described a discrepancy in the effectiveness of cisplatin plus irinotecan between primary and metastatic lesions. A 43-year-old Japanese man was referred to our hospital with refractory epigastralgia. A previous gastrointestinal endoscopy had revealed a 50-mm type 2 tumor in the abdominal esophagus...
May 2018: Case Reports in Gastroenterology
Nilantha Bandara, Orit Jacobson, Cedric Mpoy, Xiaoyuan Chen, Buck Edward Rogers
Development of somastatin (SS) peptide analogs for detection and treatment of neuroendocrine tumors has been successful with the recent FDA approval of 68Ga-DOTA-TATE and 177Lu-DOTA-TATE. The structure of these peptide constructs contains the peptide binding motif that binds to the receptor with high affinity, a chelator to complex the radioactive metal, and a linker between the peptide and chelator. However, these constructs suffer from rapid blood clearance, which limit their tumor uptake. In this study, this design has been further improved by incorporating a modification to control the in vivo pharmacokinetics...
June 21, 2018: Bioconjugate Chemistry
Junyan Xu, Yi Li, Xiaoping Xu, Jiangang Zhang, Yingjian Zhang, Xianjun Yu, Dan Huang
OBJECTIVE: Our aim of this research was to determine the value of SPECT/CT with 99m Tc-HYNIC-TOC for evaluation of the pancreatic masses which were suspected as neuroendocrine neoplasms and follow-up of patients with pancreatic neuroendocrine neoplasms. METHODS: We retrospectively analyzed 184 patients who performed 99m Tc-HYNIC-TOC SPECT/CT. All the patients were divided into two groups: one for assessment of diagnostic efficiency for pancreatic suspected masses (n = 140) and another for monitoring recurrence after surgery (n = 44)...
June 20, 2018: Annals of Nuclear Medicine
Mie Yamanaka, Kiyoto Shiga, Sho Fujiwara, Yasuhiko Mizuguchi, Sari Yasuda, Kota Ishizawa, Yuriko Saiki, Kenjiro Higashi, Takenori Ogawa, Noriko Kimura, Akira Horii
Pheochromocytomas and paragangliomas are neuroendocrine tumors which arise from adrenal medulla, and sympathetic or parasympathetic nerves, respectively. Hereditary cases afflicted by both or either pheochromocytomas and paragangliomas have been reported: these are called hereditary pheochromocytoma/paraganglioma syndromes (HPPS). Many cases of HPPS are caused by mutations of one of the succinate dehydrogenase (SDH) genes; mainly SDHB and SDHD that encode subunits for the mitochondrial respiratory chain complex II...
2018: Tohoku Journal of Experimental Medicine
Liyan Lu, Fengfang Li, Yamei Zhang, Peng Wang, Xindao Yin, Wenbin Li
RATIONALE: Small cell lung cancer accounts for 15-20% of all lung cancers and is the most common pulmonary neuroendocrine neoplasm. Most small cell lung cancers arise from lobar or main bronchi, the most common manifestations of small cell lung cancer is a large mass centrally located within the lung parenchyma or a mediastinal mass involving the hilus. Small cell lung cancer is easily ignored by clinicians without lung parenchyma and hilus involvement. Here, we report a case of small cell lung cancer, which was misdiagnosed as the lymphoma in contrast enhanced CT and Ga-DOTA-NOC PET/CT imagings...
June 2018: Medicine (Baltimore)
Shriprasad R Deshpande, Priyanka Patel, Neill Videlefsky, Dellys M Soler Rodriguez, Rene Romero, Matthew S Clifton
Paragangliomas are rare neuroendocrine tumors where hypoxia-inducible factor plays a critical role in tumorigenesis. It has been suggested that patients with congenital heart disease, in particular, may have cellular environment and relative hypoxia favorable to the development of these neuroendocrine tumors. Here, we present a case of an 11-year-old child with hypoplastic left heart syndrome previously palliated with Fontan procedure, diagnosed with paraganglioma on surveillance imaging. We present the clinical course, intervention, and outcome as well as review the possible contributory mechanisms...
May 2018: Annals of Pediatric Cardiology
Loredana Puca, Rohan Bareja, Davide Prandi, Reid Shaw, Matteo Benelli, Wouter R Karthaus, Judy Hess, Michael Sigouros, Adam Donoghue, Myriam Kossai, Dong Gao, Joanna Cyrta, Verena Sailer, Aram Vosoughi, Chantal Pauli, Yelena Churakova, Cynthia Cheung, Lesa Dayal Deonarine, Terra J McNary, Rachele Rosati, Scott T Tagawa, David M Nanus, Juan Miguel Mosquera, Charles L Sawyers, Yu Chen, Giorgio Inghirami, Rema A Rao, Carla Grandori, Olivier Elemento, Andrea Sboner, Francesca Demichelis, Mark A Rubin, Himisha Beltran
A major hurdle in the study of rare tumors is a lack of existing preclinical models. Neuroendocrine prostate cancer is an uncommon and aggressive histologic variant of prostate cancer that may arise de novo or as a mechanism of treatment resistance in patients with pre-existing castration-resistant prostate cancer. There are few available models to study neuroendocrine prostate cancer. Here, we report the generation and characterization of tumor organoids derived from needle biopsies of metastatic lesions from four patients...
June 19, 2018: Nature Communications
Adam G Sowalsky, Huihui Ye, Manoj Bhasin, Eliezer M Van Allen, Massimo Loda, Rosina T Lis, Laleh Montaser-Kouhsari, Carla Calagua, Fen Ma, Joshua W Russo, Rachel J Schaefer, Olga S Voznesensky, Zhenwei Zhang, Glenn J Bubley, Bruce Montgomery, Elahe A Mostaghel, Peter S Nelson, Mary-Ellen Taplin, Steven P Balk
Primary prostate cancer (PCa) can have extensive microheterogeneity, but its contribution to the later emergence of metastatic castration-resistant PCa (mCRPC) remains unclear. In this study, we microdissected residual PCa foci in radical prostatectomies from 18 men treated with neoadjuvant intensive androgen deprivation therapy (leuprolide, abiraterone acetate, and prednisone) and analyzed them for resistance mechanisms. Transcriptome profiling showed reduced but persistent androgen receptor (AR) activity in residual tumors with no increase in neuroendocrine differentiation...
June 19, 2018: Cancer Research
Maria Francesca Cassarino, Alberto G Ambrogio, Andrea Cassarino, Maria Rosa Terreni, Davide Gentilini, Antonella Sesta, Francesco Cavagnini, Marco Losa, Francesca Pecori Giraldi
ACTH-secreting pituitary adenomas give rise to a severe endocrinological disorder, i.e., Cushing's disease, with multifaceted clinical presentation and treatment outcomes. Experimental studies suggested that disease variability is inherent to the pituitary tumor, thus pointing to the need for further studies into tumor biology. Aim of the present study was to evaluate transcriptome expression pattern in a large series of ACTH-secreting pituitary adenoma specimens, in order to identify molecular signatures of these tumors...
June 19, 2018: Journal of Neuroendocrinology
Lunpo Wu, Fei Chen, Shujie Chen, Liangjing Wang
<br>Background: The effectiveness of current Tumor, Lymph node, Metastases (TNM) staging system in small intestinal neuroendocrine tumors (SiNETs) is unsatisfactory. Current N classification only distinguishes between node-negative and node-positive status. We aim to refine the N classification for updated TNM stage. METHODS: Patients with non-metastatic SiNETs between 1988 and 2012 were enrolled in the Surveillance, Epidemiology, and End Results (SEER) database. Using the X-tile program, we calculated an optimal cut-off value for lymph node ratio (LNR) and proposed a novel Nr category...
June 19, 2018: Neuroendocrinology
Saurabh Arora, Averilicia Passah, Nishikant A Damle, Rajiv Narang, Atul Sharma, Madhav P Yadav, Sanjana Ballal, Dinkar Bhasin, Chandrasekhar Bal
We present the case of a 35-year-old woman with metastatic neuroendocrine tumor undergoing treatment with long-acting octreotide and Lu-DOTATATE therapy. We present features of carcinoid heart disease on Ga-DOTANOC PET/CT, which revealed dilated right atrium, pericardial effusion, ascites, and congestive hepatopathy apart from the metastatic lesions in the liver. The scan cardiac findings were confirmed by echocardiography. This highlights the significance of identifying such patients early because additional management is required for carcinoid heart disease per se and a cautious approach is needed in administering amino acid infusion during PRRT that can result in fluid overload...
June 19, 2018: Clinical Nuclear Medicine
Tony Li-Geng, Guoping Cai, Harry R Aslanian
No abstract text is available yet for this article.
March 2018: VideoGIE: an official video journal of the American Society for Gastrointestinal Endoscopy
Eric M Nelsen, Ahmed Akhter, Mark E Benson, Deepak V Gopal
No abstract text is available yet for this article.
December 2017: VideoGIE: an official video journal of the American Society for Gastrointestinal Endoscopy
Alexandre Chicheportiche, Faozi Artoul, Arnon Schwartz, Simona Grozinsky-Glasberg, Amichay Meirovitz, David J Gross, Jeremy Godefroy
BACKGROUND: Peptide receptor radionuclide therapy (PRRT) with [177 Lu]-DOTA-TATE is an effective treatment of neuroendocrine tumors (NETs). After each cycle of treatment, patient dosimetry evaluates the radiation dose to the risk organs, kidneys, and bone marrow, the most radiosensitive tissues. Absorbed doses are calculated from the radioactivity in the blood and from single photon emission computed tomography (SPECT) images corrected by computed tomography (CT) acquired after each course of treatment...
June 19, 2018: EJNMMI Physics
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