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https://www.readbyqxmd.com/read/29679856/b7-h6-expression-is-induced-by-lipopolysaccharide-and-facilitates-cancer-invasion-and-metastasis-in-human-gliomas
#1
Fengyuan Che, Xiaoli Xie, Long Wang, Quanping Su, Feiyu Jia, Yufu Ye, Lanlan Zang, Jing Wang, Hongyan Li, Yanchun Quan, Cuiping You, Jiawei Yin, Zhiqiang Wang, Gen Li, Yifeng Du, Lijuan Wang
Although great progress has been made in treatment regimens, gliomas are still incurable and the 5-year survival remains poor. Studies focusing on molecules that regulate tumorigenesis or tumor immunity may provide potential therapeutic strategies for patients with glioma. B7-H6 is selectively expressed in tumor cells and plays vital roles in host immune responses. In this study, we demonstrated that B7-H6 was expressed in glioma cell lines, including CRT, U251, SHG-44, SF-295, TG-905 and U373, and tumor tissues isolated from glioma patients...
April 18, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29679277/the-role-of-mitochondrial-dna-damage-at-skeletal-muscle-oxidative-stress-on-the-development-of-type-2-diabetes
#2
Julia Matzenbacher Dos Santos, Denise Silva de Oliveira, Marcos Lazaro Moreli, Sandra Aparecida Benite-Ribeiro
Reduced cellular response to insulin in skeletal muscle is one of the major components of the development of type 2 diabetes (T2D). Mitochondrial dysfunction involves in the accumulation of toxic reactive oxygen species (ROS) that leads to insulin resistance. The aim of this study was to verify the involvement of mitochondrial DNA damage at ROS generation in skeletal muscle during development of T2D. Wistar rats were fed a diet containing 60% fat over 8 weeks and at day 14 a single injection of STZ (25 mg/kg) was administered (T2D-induced)...
April 20, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29679223/association-between-lepr-fto-mc4r-and-pparg-2-polymorphisms-with-obesity-traits-and-metabolic-phenotypes-in-school-aged-children
#3
Sílvia M Almeida, José M Furtado, Paulo Mascarenhas, Maria E Ferraz, José C Ferreira, Mariana P Monteiro, Manuel Vilanova, Fernando P Ferraz
PURPOSE: Evaluate the relationship of leptin receptor (LEPR) rs1137101, fat mass obesity-associated (FTO) receptors 9939609, melanocortin-4 receptors (MC4R) rs2229616 and rs17782313, and proliferator-activated receptor-gamma (PPARG) rs1801282 with clinical and metabolic phenotypes in prepubertal children. RESEARCH QUESTION: What is the effect of polymorphisms on clinical and metabolic phenotypes in prepubertal children? METHODS: A cross-sectional descriptive study was performed to evaluate anthropometric features, percentage body fat (%BF), biochemical parameters, and genotype in 773 prepubertal children...
April 20, 2018: Endocrine
https://www.readbyqxmd.com/read/29678978/community-based-diagnosis-of-non-communicable-diseases-and-their-risk-factors-in-rural-and-urban-haiti-a-cross-sectional-prevalence-study
#4
Vincent DeGennaro, Stuart Malcolm, Lindsay Crompton, Krishna Vaddiparti, Lazarus K Mramba, Catherine Striley, Linda Cottler, Kellee Taylor, Robert Leverence
OBJECTIVE: To estimate the prevalence of hypertension, diabetes and chronic kidney disease and their risk factors in a rural and urban region of Haiti. SETTING AND PARTICIPANTS: Community health workers enumerated 2648 households (909 rural and 1739 urban) via a multistage cluster random sampling method from July 2015 to May 2016, completed 705 rural and 1419 urban assessments for adults aged 25-65 years. OUTCOME MEASURES: We performed a WHO STEPS based questionnaire, measured two blood pressure values, weight, height, abdominal circumference and point of care test finger stick blood sample for haemoglobin A1c, creatinine and cholesterol (total, high density lipoprotein (HDL) and triglycerides)...
April 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29678681/genome-wide-meta-analysis-identifies-novel-gender-specific-loci-associated-with-thyroid-antibodies-level-in-croatians
#5
Antonela Matana, Marijana Popović, Thibaud Boutin, Vesela Torlak, Dubravka Brdar, Ivana Gunjača, Ivana Kolčić, Vesna Boraska Perica, Ante Punda, Ozren Polašek, Caroline Hayward, Maja Barbalić, Tatijana Zemunik
Autoimmune thyroid diseases (AITD) are multifactorial endocrine diseases most frequently accompanied by Tg and TPO autoantibodies. Both antibodies have a higher prevalence in females and act under a strong genetic influence. To identify novel variants underlying thyroid antibody levels, we performed GWAS meta-analysis on the plasma levels of TgAb and TPOAb in three Croatian cohorts, as well as gender specific GWAS and a bivariate analysis. No significant association was detected with the level of TgAb and TPOAb in the meta-analysis of GWAS or bivariate results for all individuals...
April 17, 2018: Genomics
https://www.readbyqxmd.com/read/29678661/role-of-heat-shock-transcription-factor-1-hsf1-upregulated-macrophage-in-ameliorating-pressure-overload-induced-heart-failure-in-mice
#6
Peizhao Du, Yaowei Chang, Fangjie Dai, Chunyan Wei, Qi Zhang, Jiming Li
In order to explore the role of macrophages in HSF1-mediated alleviation of heart failure, mice model of pressure overload-induced heart failure was established using transverse aortic constriction (TAC). Changes in cardiac function and morphology were studied in TAC and SHAM groups using ultrasonic device, tissue staining, electron microscopy, real-time quantitative polymerase chain reaction (RT-QPCR), and Western blotting. We found that mice in the TAC group showed evidence of impaired cardiac function and aggravation of fibrosis on ultrasonic and histopathological examination when compared to those in the SHAM group...
April 17, 2018: Gene
https://www.readbyqxmd.com/read/29678641/liver-directed-microrna-7a-depletion-induces-nonalcoholic-fatty-liver-disease-by-stabilizing-yy1-mediated-lipogenic-pathways-in-zebrafish
#7
Chi-Yu Lai, Chiu-Ya Lin, Chia-Chun Hsu, Kun-Yun Yeh, Guor Mour Her
Nonalcoholic fatty liver disease (NAFLD) has been associated with the function and changes in expression levels of microRNAs (miRs). MiR-7 has been proven to play an important role in many cellular processes; however, its functions in the context of liver lipogenesis remain unknown. We applied the microRNA-sponge (miR-SP) technology and generated transgenic miR-7a-SP models (hC7aSP and bC7aSP), which disrupted the activities of hepatic miR-7a and induced the early onset of NAFLD and nonalcoholic steatohepatitis (NASH) in zebrafish...
April 17, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29678637/is-the-occlusion-site-of-the-lenticulostriate-artery-identified-on-admission-related-to-clinical-prognosis-in-patients-with-lacunar-stroke
#8
Masaki Naganuma, Yuichiro Inatomi, Makoto Nakajima, Takeshi Ohta, Toshiro Yonehara, Yukio Ando
BACKGROUND: The mechanism of lacunar stroke (LS) is rather speculative due to the lack of neuropathological evidence in clinical practice. To explore the significance of the occlusion site of the lenticulostriate artery (LSA) to this mechanism, we investigated the characteristics and prognosis of patients with LS with proximal occlusions. MATERIALS AND METHODS: We studied 202 patients with acute LS in the region of the LSA. The presumed occlusion site of the LSA was assessed on coronal, diffusion-weighted magnetic resonance images...
April 17, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29678607/association-between-hypertension-and-metabolic-disorders-among-elderly-patients-in-north-jordan
#9
Nuha Alwardat, Laura Di Renzo, Renata Costa de Miranda, Sofian Alwardat, Paola Sinibaldi Salimei, Antonino De Lorenzo
BACKGROUND: Hypertension (HTN), dyslipidemia and hyperglycemia are major risk factors for cardiovascular disease, accounting for the highest morbidity and mortality among the elderly Jordanian population. This study aimed to evaluate serum lipid and glucose profiles of hypertensive patients and normotensive controls, and determine the risk factors for HTN among elderly population in Jordan. METHODS: A cross-sectional study was carried out among 200 participants, including 111 hypertensive patients and 89 normotensive controls from June to October 2017 in North Jordan...
April 12, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29678606/ketogenic-diet-high-intensity-interval-training-hiit-and-memory-training-in-the-treatment-of-mild-cognitive-impairment-a-case-study
#10
Kaitlyn Dahlgren, Kelly J Gibas
Alzheimer's disease (AD) deaths have increased by 89% since 2000. This alarming trajectory of neurological disease highlights the failure of current best practice. Deteriorating brain fuel supply is the nemesis of intact neurological health. Cerebral hypo-metabolism associated with AD occurs years before onset. Both the ketogenic diet and calorie restriction (fasting) lead to a compensatory rise in ketones to improve energy deficits in the brain derived from cerebral insulin resistance. Two forms of ketone bodies, β-hydroxybutyrate and acetoacetate, fuel the brain during starvation, fasting and strenuous exercise...
April 11, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29678570/overexpression-of-nrk1-ameliorates-diet-and-age-induced-hepatic-steatosis-and-insulin-resistance
#11
Rui Fan, Jing Cui, Feng Ren, Qingzhi Wang, Yanmei Huang, Bin Zhao, Lai Wei, Xinlai Qian, Xiwen Xiong
NAD+ is a co-enzyme in redox reactions and a substrate required for activity of various enzyme families, including Sirtuins and poly(ADP-ribose) polymerases. Dietary supplementation of NAD+ precursors nicotinamide mononucleotide (NMN) or nicotinamide riboside (NR) protects against metabolic disease, neurodegenerative disorders and age-related physiological decline in mammals. Here we sought to identify the roles of nicotinamide riboside kinase 1 (NRK1) plays in regulating hepatic NAD+ biosynthesis and lipid metabolism...
April 17, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29678421/growth-hormone-receptor-deficient-pigs-resemble-the-pathophysiology-of-human-laron-syndrome-and-reveal-altered-activation-of-signaling-cascades-in-the-liver
#12
Arne Hinrichs, Barbara Kessler, Mayuko Kurome, Andreas Blutke, Elisabeth Kemter, Maren Bernau, Armin M Scholz, Birgit Rathkolb, Simone Renner, Sebastian Bultmann, Heinrich Leonhardt, Martin Hrabĕ de Angelis, Hiroshi Nagashima, Andreas Hoeflich, Werner F Blum, Martin Bidlingmaier, Rüdiger Wanke, Maik Dahlhoff, Eckhard Wolf
OBJECTIVE: Laron syndrome (LS) is a rare, autosomal recessive disorder in humans caused by loss-of-function mutations of the growth hormone receptor (GHR) gene. To establish a large animal model for LS, pigs with GHR knockout (KO) mutations were generated and characterized. METHODS: CRISPR/Cas9 technology was applied to mutate exon 3 of the GHR gene in porcine zygotes. Two heterozygous founder sows with a 1-bp or 7-bp insertion in GHR exon 3 were obtained, and their heterozygous F1 offspring were intercrossed to produce GHR-KO, heterozygous GHR mutant, and wild-type pigs...
March 15, 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/29678208/glial-interleukin-1%C3%AE-upregulates-neuronal-sodium-channel-1-7-in-trigeminal-ganglion-contributing-to-temporomandibular-joint-inflammatory-hypernociception-in-rats
#13
Peng Zhang, Rui-Yun Bi, Ye-Hua Gan
BACKGROUND: The proinflammatory cytokine interleukin-1β (IL-1β) drives pain by inducing the expression of inflammatory mediators; however, its ability to regulate sodium channel 1.7 (Nav1.7), a key driver of temporomandibular joint (TMJ) hypernociception, remains unknown. IL-1β induces cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2). We previously showed that PGE2 upregulated trigeminal ganglionic Nav1.7 expression. Satellite glial cells (SGCs) involve in inflammatory pain through glial cytokines...
April 20, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29678178/status-of-lipid-and-lipoprotein-in-female-breast-cancer-patients-at-initial-diagnosis-and-during-chemotherapy
#14
Xin Li, Zi-Li Liu, Yu-Tuan Wu, He Wu, Wei Dai, Bilal Arshad, Zhou Xu, Hao Li, Kai-Nan Wu, Ling-Quan Kong
BACKGROUND: The lipid profile status among breast cancer patients at initial diagnosis and during chemotherapy remain controversial. The aim of this study is to study the status of lipid and lipoprotein in female breast cancer patients at initial diagnosis and during chemotherapy. METHODS: We conducted a retrospective cohort study of the status of the lipid and lipoprotein in 1054 primarily diagnosed breast cancer patients and 2483 normal controls with age stratification, from July 2015 to October 2016...
April 20, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29678174/age-and-gender-specific-distribution-of-metabolic-syndrome-components-in-east-china-role-of-hypertriglyceridemia-in-the-spect-china-study
#15
Boren Jiang, Yanjun Zheng, Yingchao Chen, Yi Chen, Qin Li, Chunfang Zhu, Ningjian Wang, Bing Han, Hualing Zhai, Dongping Lin, Yingli Lu
BACKGROUND: Chinese population are experiencing remarkably changes of economic and cultural environments. The present study was to examine the prevalence of metabolic syndrome (MetS) by age between genders and to investigate the current characteristics of MetS and its components in China. METHODS: SPECT-China is a population-based cross-sectional survey on Chinese adults aged ≥18 years in East China. A total of 10,441 Chinese residents participated in anthropometric and laboratory measurements...
April 20, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29677785/catalytic-pyrolysis-of-pinus-densiflora-over-mesoporous-al%C3%A2-o%C3%A2-catalysts
#16
Young-Min Kim, Gwang Hoon Rhee, Chang Hyun Ko, Ki Hoon Kim, Kyeong Youl Jung, Ji Man Kim, Young-Kwon Park
The thermal and catalytic pyrolysis of Pinus densiflora (P. densiflora) were performed to test the catalytic cracking efficiency of two mesoporous Al2O3 catalysts with different surface areas. Thermogravimetric analysis (TGA) of P. densiflora showed that the differential TG (DTG) peak heights obtained from catalytic pyrolysis were smaller than those of non-catalytic pyrolysis due to the conversion of the reaction intermediates to coke. Pyrolyzer-gas chromatography/mass spectrometry analysis/flame ionization detection (Py-GC/MS/FID) suggested that using the Al2O3 catalysts, the yields of phenols and levoglucosan decreased with a concomitant increase in the yields of aldehydes, alcohol, ketones, and furans...
September 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29677768/amorphous-fluoropolymer-membrane-for-gas-separation-applications
#17
Tae Yang Son, Mi Ae Jeong, Sang Yong Nam
Amorphous fluoropolymers have been studied in the past few decades and received extensive attention due to their unique and useful properties. One of the remarkable properties of amorphous fluoropolymers is high fractional free volume (FFV), and they tend to retain large amounts of solvent inside their polymer chains. In this study, amorphous flouoropolymer membranes were employed to examine the influences of the residual solvent and drying condition on the thermal properties, gas permeation behavior, and structure change by the polymer chains...
September 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29677743/mechanical-and-thermal-insulation-properties-of-porous-silica-polyurethane-composites
#18
Chunyuan Liu, Younghwan Kwon
Porous hydroxyl-terminated polybutadiene-based polyurethane (HPU) composites containing various hollow glass microspheres (HGMs) up to 75 vol.% were synthesized by one-step bulk polyaddition-type polymerization. An unfilled (non-porous) HPU sample was also prepared as a reference. The thermal conductivity of the HPU/HGM composites, which are considered as a three-phasic material composed of a bulk HPU matrix, silicate thin layer, and pores, could be predicted perfectly by the Felske model. The thermal properties, such as Tg and thermal stability, of the HPU/HGM composites were affected slightly by the addition of HGMs compared to the unfilled HPU...
September 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29677691/iodine-status-of-pregnant-women-from-a-coastal-brazilian-state-after-the-reduction-in-recommended-iodine-concentration-in-table-salt-according-to-governmental-requirements
#19
Débora Ayres Saraiva, Nathalie Anne de Oliveira E Silva de Morais, Carolina Martins Corcino, Tatiana Martins Benvenuto Louro Berbara, Annie Schtscherbyna, Mischelle Santos, Heron Botelho, Mario Vaisman, Patrícia de Fátima Dos Santos Teixeira
OBJECTIVE: To evaluate iodine status among pregnant women from a coastal state after Brazilian governmental resolution reducing iodine concentrations in table salt. Secondarily, we correlated urinary iodine concentration (UIC) with thyroid volume and hormones. METHODS: Inductively coupled plasma mass spectrometry was used to assess UIC from 629 samples of 244 first trimester pregnant women. Thyroid ultrasound, serum thyroglobulin, thyrotropin, free thyroxine, and antithyroid antibodies were measured as iodine concentrations on samples of table salt from patient's home...
February 14, 2018: Nutrition
https://www.readbyqxmd.com/read/29677628/circulating-metabolomic-profile-can-predict-dyslipidemia-in-hiv-patients-undergoing-antiretroviral-therapy
#20
Esther Rodríguez-Gallego, Josep Gómez, Pere Domingo, Sara Ferrando-Martínez, Joaquim Peraire, Consuelo Viladés, Sergi Veloso, Miguel López-Dupla, Raúl Beltrán-Debón, Verónica Alba, Montserrat Vargas, Alfonso J Castellano, Manuel Leal, Yolanda María Pacheco, Ezequiel Ruiz-Mateos, Félix Gutiérrez, Francesc Vidal, Anna Rull
BACKGROUND AND AIMS: Dyslipidemia in HIV-infected patients is unique and pathophysiologically associated with host factors, HIV itself and the use of antiretroviral therapy (ART). The use of nuclear magnetic resonance spectroscopy (NMR) provides additional data to conventional lipid measurements concerning the number of lipoprotein subclasses and particle sizes. METHODS: To investigate the ability of lipoprotein profile, we used a circulating metabolomic approach in a cohort of 103 ART-naive HIV-infected patients, who were initiating non-nucleoside analogue transcriptase inhibitor (NNRTI)-based ART, and we subsequently followed up these patients for 36 months...
April 9, 2018: Atherosclerosis
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