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https://www.readbyqxmd.com/read/29427395/minimum-echo-time-press-based-proton-observed-carbon-edited-poce-mrs-in-rat-brain-using-simultaneous-editing-and-localization-pulses
#1
Chathura Kumaragamage, Dan Madularu, Axel P Mathieu, Derek Lupinsky, Robin A de Graaf, Jamie Near
PURPOSE: Indirect 13 C MRS by proton-observed carbon editing (POCE) is a powerful method to study brain metabolism. The sensitivity of POCE-MRS can be enhanced through the use of short TEs, which primarily minimizes homonuclear J-evolution related losses; previous POCE-MRS implementations use longer than optimal echo times due to sequence limitations, or short TE image selected in vivo spectroscopy-based multi-shot acquisitions for 3D localization. To that end, this paper presents a novel single-shot point resolved spectroscopy (PRESS)-localized POCE-MRS sequence that involves the application of simultaneous editing and localization pulses (SEAL)-PRESS, allowing the TE to be reduced to a theoretically optimal value of ∼ 1/JHC ...
February 9, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29414127/striatal-neurometabolite-levels-in-patients-with-schizophrenia-undergoing-long-term-antipsychotic-treatment-a-proton-magnetic-resonance-spectroscopy-and-reliability-study
#2
Eric Plitman, Sofia Chavez, Shinichiro Nakajima, Yusuke Iwata, Jun Ku Chung, Fernando Caravaggio, Julia Kim, Youssef Alshehri, M Mallar Chakravarty, Vincenzo De Luca, Gary Remington, Philip Gerretsen, Ariel Graff-Guerrero
Previous proton magnetic resonance spectroscopy (1H-MRS) studies have reported disrupted levels of various neurometabolites in patients with schizophrenia. An area of particular interest within this patient population is the striatum, which is highly implicated in the pathophysiology of schizophrenia. The present study examined neurometabolite levels in the striatum of 12 patients with schizophrenia receiving antipsychotic treatment for at least 1 year and 11 healthy controls using 3-Tesla 1H-MRS (PRESS, TE = 35 ms)...
January 31, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29414126/proton-magnetic-resonance-spectroscopy-changes-after-lithium-treatment-systematic-review
#3
REVIEW
Agata Szulc, Magdalena Wiedlocha, Napoleon Waszkiewicz, Beata Galińska-Skok, Piotr Marcinowicz, Jacek Gierus, Anna Mosiolek
1H MRS is widely used in the research of mental disorders. It enables evaluation of concentration or ratios of several metabolites, which play important roles in brain metabolism: N-acetylaspartate (NAA), choline containing compounds, myo-inositol and glutamate, glutamine and GABA (together as Glx complex or separately). Specifically in bipolar disorder brain metabolite abnormalities include mostly NAA reduces and Glx increases in different brain regions. Bipolar disorder is associated with impairment in neurotrophic and cellular plasticity, resilience pathways and in neuroprotective processes...
January 17, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29391242/sex-and-sex-hormone-related-variations-in-energy-metabolic-frontal-brain-asymmetries-a-magnetic-resonance-spectroscopy-study
#4
Helene Hjelmervik, Markus Hausmann, Marco Hirnstein, Alexander R Craven, Kenneth Hugdahl, Karsten Specht
Creatine is a key regulator of brain energy homeostasis, and well-balanced creatine metabolism is central in healthy brain functioning. Still, the variability of brain creatine metabolism is largely unattended in magnetic resonance spectroscopy (MRS) research. In the human brain, marginal sex differences in creatine levels have been found in the prefrontal cortex. It is however not known to what degree these sex differences are stable or change with varying gonadal hormone levels. The current study therefore investigated creatine in the prefrontal cortex across the menstrual cycle...
January 29, 2018: NeuroImage
https://www.readbyqxmd.com/read/29390267/rehabilitation-program-based-on-sensorimotor-recovery-improves-the-static-and-dynamic-balance-and-modifies-the-basal-ganglia-neurochemistry-a-pilot-1h-mrs-study-on-parkinson-s-disease-patients
#5
Stefano Delli Pizzi, Rosa Grazia Bellomo, Simona Maria Carmignano, Emilio Ancona, Raffaella Franciotti, Marco Supplizi, Giovanni Barassi, Marco Onofrj, Laura Bonanni, Raoul Saggini
Rehabilitation interventions represent an alternative strategy to pharmacological treatment in order to slow or reverse some functional aspects of disability in Parkinson's disease (PD). To date, the neurophysiological mechanisms underlying rehabilitation-mediated improvement in PD patients are still poorly understood. Interestingly, growing evidence has highlighted a key role of the glutamate in neurogenesis and brain plasticity. The brain levels of glutamate, and of its precursor glutamine, can be detected in vivo and noninvasively as "Glx" by means of proton magnetic resonance spectroscopy (H-MRS)...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29383178/predictive-value-of-1h-mr-spectroscopy-and-18f-fdg-pet-ct-for-local-control-of-advanced-oropharyngeal-and-hypopharyngeal-squamous-cell-carcinoma-receiving-chemoradiotherapy-a-prospective-study
#6
Chih-Hua Yeh, Gigin Lin, Jiun-Jie Wang, Chien-Yu Lin, Shang-Yueh Tsai, Yu-Chun Lin, Yi-Ming Wu, Sheung-Fat Ko, Hung-Ming Wang, Sheng-Chieh Chan, Tzu-Chen Yen, Chun-Ta Liao, Shu-Hang Ng
Purpose: To determine whether pretreatment in vivo 1H magnetic resonance (MR) spectroscopy at 3 Tesla (T) and 18F-FDG PET/CT can offer predictive power regarding the local control of oropharyngeal or hypopharyngeal squamous cell carcinoma (OHSCC) patients. Materials and Methods: 1H MR spectroscopy was performed in addition to conventional MR imaging before definitive chemoradiotherapy in 58 patients with advanced OHSCC. The relationship of local control with the 1H MR spectroscopy and 18F-FDG PET/CT parameters was analyzed...
December 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29378291/glutamine-glutamate-glx-concentration-in-prefrontal-cortex-predicts-reversal-learning-performance-in-the-marmoset
#7
Agnès Lacreuse, Constance M Moore, Matthew LaClair, Laurellee Payne, Jean A King
This study used Magnetic Resonance Spectroscopy (MRS) to identify potential neurometabolitic markers of cognitive performance in male (n =7) and female (n=8) middle-aged (~5 years old) common marmosets (Callithrix jacchus). Anesthetized marmosets were scanned with a 4.7 T/40cm horizontal magnet equipped with 450 mT/m magnetic field gradients and a 20-G/cm magnetic field gradient insert, within 3 months of completing the CANTAB serial Reversal Learning task. Neurometabolite concentrations of N-Acetyl Asparate, Myo-Inositol, Choline, Phosphocreatine+creatine, Glutamate and Glutamine were acquired from a 3 mm3 voxel positioned in the Prefrontal Cortex (PFC)...
January 26, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29377412/high-fat-diet-induces-a-neurometabolic-state-characterized-by-changes-in-glutamate-and-n-acetylaspartate-pools-associated-with-early-glucose-intolerance-an-in-vivo-multimodal-mri-study
#8
Mário Ribeiro, João Castelhano, Lorena I Petrella, José Sereno, Tiago Rodrigues, Christian Neves, Liliana Letra, Filipa I Baptista, Raquel Seiça, Paulo Matafome, Miguel Castelo-Branco
BACKGROUND: Type-2 diabetes mellitus (T2DM) is a metabolic disorder with a broad range of complications in the brain that depend on the conditions that precede its onset, such as obesity and metabolic syndromes. It has been suggested that neurotransmitter and metabolic perturbations may emerge even before the early stages of T2DM and that high-caloric intake could adversely influence the brain in such states. Notwithstanding, evidence for neurochemical and structural alterations in these conditions are still sparse and controversial...
January 26, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29306050/glutamate-quantification-by-press-or-mega-press-validation-repeatability-and-concordance
#9
Tamar M van Veenendaal, Walter H Backes, Frank C G van Bussel, Richard A E Edden, Nicolaas A J Puts, Albert P Aldenkamp, Jacobus F A Jansen
PURPOSE: While PRESS is often employed to measure glutamate concentrations, MEGA-PRESS enables simultaneous Glx (glutamate and glutamine) and GABA measurements. This study aimed to compare validation, repeatability, and concordance of different approaches for glutamate quantification at 3T to aid future studies in their selection of the appropriate sequence and quantification method. MATERIALS AND METHODS: Nine phantoms with different glutamate and glutamine concentrations and five healthy participants were scanned twice to assess respectively the validation and repeatability of measurements with PRESS and MEGA-PRESS...
January 3, 2018: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29279021/increased-myo-inositol-in-primary-motor-cortex-of-contact-sport-athletes-without-a-history-of-concussion
#10
Genevieve Lefebvre, Emilie Chamard, Sebastien Proulx, Sara Tremblay, Mark Halko, Salil Soman, Elaine de Guise, Alvaro Pascual-Leone, Hugo Theoret
OBJECTIVE: Determine whether repetitive hits to the head at a subclinical level are associated with structural and functional brain abnormalities and if these effects are influenced by high levels of fitness associated with intense physical activity. METHODS: Seventy-two college students were recruited: 24 non-athletes, 24 athletes practicing a varsity contact sport, and 24 athletes practicing a varsity non-contact sport. They were recruited for a neuropsychological evaluation and a magnetic resonance imaging session that included magnetic resonance spectroscopy of primary motor cortex (M1) and prefrontal cortex and susceptibility-weighted imaging...
December 26, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29259538/reliability-of-glutamate-quantification-in-human-nucleus-accumbens-using-proton-magnetic-resonance-spectroscopy-at-a-70-cm-wide-bore-clinical-3t-mri-system
#11
Xi-Long Liu, Long Li, Jian-Neng Li, Jia-Hui Rong, Bo Liu, Ze-Xuan Hu
The human nucleus accumbens is a challenging region to study using proton magnetic resonance spectroscopy (1H-MRS) on a 70-cm wide-bore clinical 3T MRI system. The aim of this study was to investigate the reliability for quantitative measurement of glutamate concentration in the nucleus accumbens using a 70-cm wide-bore clinical 3T MRI. 1H-MRS of the nucleus accumbens was acquired using the Point-Resolved Spectroscopic Sequence (PRESS) with echo time of 40 ms from 10 healthy volunteers (5 female; age range: 18-30 years) on two separate visits (a baseline, and 1-month time point)...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29242361/measuring-cerebral-and-cerebellar-glutathione-in-children-using-1h-mega-press-mrs
#12
F Raschke, R Noeske, R A Dineen, D P Auer
BACKGROUND AND PURPOSE: Glutathione is an important antioxidant in the human brain and therefore of interest in neurodegenerative disorders. The purpose of this study was to investigate the feasibility of measuring glutathione in healthy nonsedated children by using the 1H Mescher-Garwood point-resolved spectroscopy (MEGA-PRESS) sequence at 3T and to compare glutathione levels between the medial parietal gray matter and the cerebellum. MATERIALS AND METHODS: Glutathione was measured using MEGA-PRESS MRS (TR = 1...
December 14, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29224573/brain-glutamate-in-medication-free-depressed-patients-a-proton-mrs-study-at-7-tesla
#13
Beata R Godlewska, Charles Masaki, Ann L Sharpley, Philip J Cowen, Uzay E Emir
BACKGROUND: The possible role of glutamate in the pathophysiology and treatment of depression is of intense current interest. Proton magnetic resonance spectroscopy (MRS) enables the detection of glutamate in the living human brain and meta-analyses of previous MRS studies in depressed patients have suggested that glutamate levels are decreased in anterior brain regions. Nevertheless, at conventional magnetic field strengths [1.5-3 Tesla (T)], it is difficult to separate glutamate from its metabolite and precursor, glutamine, with the two often being measured together as Glx...
December 11, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/29203059/increased-glutamate%C3%A2-glutamine-levels-in-the-thalamus-of-patients-with-essential-tremor-a-preliminary-proton-mr-spectroscopic-study
#14
Gaetano Barbagallo, Gennarina Arabia, Fabiana Novellino, Rita Nisticò, Maria Salsone, Maurizio Morelli, Federico Rocca, Andrea Quattrone, Manuela Caracciolo, Umberto Sabatini, Andrea Cherubini, Aldo Quattrone
INTRODUCTION: The aim of this study was to investigate the thalamic biochemical profile in patients with essential tremor (ET), using proton magnetic resonance spectroscopy (1H-MRS), and to explore the correlations between clinical and biochemical data. METHODS: Sixteen patients with ET and 14 healthy controls participated in this study. After conventional MR imaging, single-voxel 1H-MRS (TR = 2000 ms; TE = 28 ms) was performed by using a PROBE-SV system implemented on a 3-T scanner...
November 28, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29177616/medial-frontal-lobe-neurochemistry-in-autism-spectrum-disorder-is-marked-by-reduced-n-acetylaspartate-and-unchanged-gamma-aminobutyric-acid-and-glutamate%C3%A2-%C3%A2-glutamine-levels
#15
Andreia Carvalho Pereira, Inês R Violante, Susana Mouga, Guiomar Oliveira, Miguel Castelo-Branco
The nature of neurochemical changes in autism spectrum disorder (ASD) remains controversial. We compared medial prefrontal cortex (mPFC) neurochemistry of twenty high-functioning children and adolescents with ASD without associated comorbidities and fourteen controls. We observed reduced total N-acetylaspartate (tNAA) and total creatine, increased Glx/tNAA but unchanged glutamate + glutamine (Glx) and unchanged absolute or relative gamma-aminobutyric acid (GABA+) in the ASD group. Importantly, both smaller absolute and relative GABA+ levels were associated with worse communication skills and developmental delay scores assessed by the autism diagnostic interview-revised (ADI-R)...
November 24, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29159914/gaba-concentration-in-sensorimotor-cortex-following-high-intensity-exercise-and-relationship-to-lactate-levels
#16
James P Coxon, Robin F H Cash, Joshua J Hendrikse, Nigel C Rogasch, Ellen Stavrinos, Chao Suo, Murat Yücel
High-intensity exercise increases the concentration of circulating lactate. Cortical uptake of blood borne lactate increases during and following exercise, however the potential relationship with changes in the concentration of neurometabolites remains unclear. While changes in neurometabolite concentration have previously been demonstrated in primary visual cortex following exercise, it remains unknown whether these changes extend to regions such as sensorimotor cortex (SM) or executive regions such as dorsolateral prefrontal cortex (DLPFC)...
November 21, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29150548/defense-against-reactive-carbonyl-species-involves-at-least-three-subcellular-compartments-where-individual-components-of-the-system-respond-to-cellular-sugar-status
#17
Jessica Schmitz, Isabell C Dittmar, Jörn D Brockmann, Marc Schmidt, Meike Hüdig, Alessandro W Rossoni, Veronica G Maurino
Methylglyoxal (MGO) and glyoxal (GO) are toxic reactive carbonyl species generated as by-products of glycolysis. The pre-emption pathway for detoxification of these products, the glyoxalase (GLX) system, involves two consecutive reactions catalyzed by GLXI and GLXII. In Arabidopsis thaliana, the GLX system is encoded by three homologs of GLXI and three homologs of GLXII, from which several predicted GLXI and GLXII isoforms can be derived through alternative splicing. We identified the physiologically relevant splice forms using sequencing data and demonstrated that the resulting isoforms have different subcellular localizations...
November 17, 2017: Plant Cell
https://www.readbyqxmd.com/read/29145203/evaluation-of-mental-disorders-using-proton-magnetic-resonance-spectroscopy-in-dialysis-and-predialysis-patients
#18
Chun-Yun Zhang, Ying Chen, Shan Chen, Xiang-Chuang Kong, Yuan Liu, Chao-Qun You, Cheng Wan, Philip A Bondzie, Hua Su, Chun Zhang, Fang-Fang He
BACKGROUND/AIMS: Psychological complications are prevalent in patients with chronic kidney disease (CKD). This study aimed to investigate mental disorders in stage 4-5 CKD patients, to detect metabolite concentrations in the brain by proton magnetic resonance spectroscopy (1H-MRS) and to compare the effects of different dialysis therapies on mental disorders in end-stage renal disease (ESRD). METHODS: The sample population was made up of predialysis (13), hemodialysis (HD) (13), and peritoneal dialysis (PD) patients (12)...
November 21, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29130590/quantification-of-gaba-glutamate-and-glutamine-in-a-single-measurement-at-3%C3%A2-t-using-gaba-edited-mega-press
#19
Faezeh Sanaei Nezhad, Adriana Anton, Emilia Michou, JeYoung Jung, Laura M Parkes, Stephen R Williams
γ-Aminobutyric acid (GABA) and glutamate (Glu), major neurotransmitters in the brain, are recycled through glutamine (Gln). All three metabolites can be measured by magnetic resonance spectroscopy in vivo, although GABA measurement at 3 T requires an extra editing acquisition, such as Mescher-Garwood point-resolved spectroscopy (MEGA-PRESS). In a GABA-edited MEGA-PRESS spectrum, Glu and Gln co-edit with GABA, providing the possibility to measure all three in one acquisition. In this study, we investigated the reliability of the composite Glu + Gln (Glx) peak estimation and the possibility of Glu and Gln separation in GABA-edited MEGA-PRESS spectra...
November 12, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/29079815/occipital-gaba-levels-in-older-adults-and-their-relationship-to-visual-perceptual-suppression
#20
Kabilan Pitchaimuthu, Qi-Zhu Wu, Olivia Carter, Bao N Nguyen, Sinyeob Ahn, Gary F Egan, Allison M McKendrick
Several studies have attributed certain visual perceptual alterations in older adults to a likely decrease in GABA (Gamma Aminobutyric Acid) concentration in visual cortex, an assumption based on findings in aged non-human primates. However, to our knowledge, there is no direct evidence for an age-related decrease in GABA concentration in human visual cortex. Here, we estimated visual cortical GABA levels and Glx (combined estimate of glutamate and glutamine) levels using magnetic resonance spectroscopy. We also measured performance for two visual tasks that are hypothesised to be mediated, at least in part, by GABAergic inhibition: spatial suppression of motion and binocular rivalry...
October 27, 2017: Scientific Reports
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