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https://www.readbyqxmd.com/read/29518282/pet-guided-mr-spectroscopy-in-alzheimer-s-disease
#1
Nasim Sheikh-Bahaei, S Ahmad Sajjadi, Roido Manavaki, Mary McLean, John T O'Brien, Jonathan H Gillard
OBJECTIVES: To determine if the level of metabolites in MR Spectroscopy (MRS) is a representative marker of underlying pathological changes identified in PET images in Alzheimer's disease (AD). METHODS: We performed PET-guided MRS in cases of probable AD, Mild Cognitive Impairment (MCI) and healthy controls (HC). All participants were imaged by11 C-Pittsburgh Compound B (11 C-PiB) and18 F-fluorodeoxy-glucose (18 F-FDG)-PET followed by 3T MRS. PET images were assessed both visually and using standardized uptake value ratios (SUVR)...
March 8, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29511334/psychostimulant-drug-effects-on-glutamate-glx-and-creatine-in-the-anterior-cingulate-cortex-and-subjective-response-in-healthy-humans
#2
Tara L White, Mollie A Monnig, Edward G Walsh, Adam Z Nitenson, Ashley D Harris, Ronald A Cohen, Eric C Porges, Adam J Woods, Damon G Lamb, Chelsea A Boyd, Sinda Fekir
Prescription psychostimulants produce rapid changes in mood, energy, and attention. These drugs are widely used and abused. However, their effects in human neocortex on glutamate and glutamine (pooled as Glx), and key neurometabolites such as N-acetylaspartate (tNAA), creatine (tCr), choline (Cho), and myo-inositol (Ins) are poorly understood. Changes in these compounds could inform the mechanism of action of psychostimulant drugs and their abuse potential in humans. We investigated the acute impact of two FDA-approved psychostimulant drugs on neurometabolites using magnetic resonance spectroscopy (1 H MRS)...
March 6, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29506576/effects-of-isoflurane-sevoflurane-propofol-and-alfaxalone-on-brain-metabolism-in-dogs-assessed-by-proton-magnetic-resonance-spectroscopy-1-h-mrs
#3
Franz Josef Söbbeler, Inés Carrera, Kirby Pasloske, Millagahamada Gedara Ranasinghe, Patrick Kircher, Sabine Beate Rita Kästner
BACKGROUND: The purpose of this study was to determine the effects of isoflurane, sevoflurane, propofol and alfaxalone on the canine brain metabolite bioprofile, measured with single voxel short echo time proton magnetic resonance spectroscopy at 3 Tesla. Ten adult healthy Beagle dogs were assigned to receive isoflurane, sevoflurane, propofol and alfaxalone at 3 different dose rates each in a randomized cross-over study design. Doses for isoflurane, sevoflurane, propofol and alfaxalone were FE 'Iso 1...
March 5, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29488277/the-increase-in-medial-prefrontal-glutamate-glutamine-concentration-during-memory-encoding-is-associated-with-better-memory-performance-and-stronger-functional-connectivity-in-the-human-medial-prefrontal-thalamus-hippocampus-network
#4
Jan-Willem Thielen, Donghyun Hong, Seyedmorteza Rohani Rankouhi, Jens Wiltfang, Guillén Fernández, David G Norris, Indira Tendolkar
The classical model of the declarative memory system describes the hippocampus and its interactions with representational brain areas in posterior neocortex as being essential for the formation of long-term episodic memories. However, new evidence suggests an extension of this classical model by assigning the medial prefrontal cortex (mPFC) a specific, yet not fully defined role in episodic memory. In this study, we utilized 1H magnetic resonance spectroscopy (MRS) and psychophysiological interaction (PPI) analysis to lend further support for the idea of a mnemonic role of the mPFC in humans...
February 27, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29484149/randomised-controlled-trial-of-simvastatin-treatment-for-autism-in-young-children-with-neurofibromatosis-type-1-santa
#5
Stavros Stivaros, Shruti Garg, Maria Tziraki, Ying Cai, Owen Thomas, Joseph Mellor, Andrew A Morris, Carly Jim, Karolina Szumanska-Ryt, Laura M Parkes, Hamied A Haroon, Daniela Montaldi, Nicholas Webb, John Keane, Francisco X Castellanos, Alcino J Silva, Sue Huson, Stephen Williams, D Gareth Evans, Richard Emsley, Jonathan Green
Background: Neurofibromatosis 1 (NF1) is a monogenic model for syndromic autism. Statins rescue the social and cognitive phenotype in animal knockout models, but translational trials with subjects > 8 years using cognition/behaviour outcomes have shown mixed results. This trial breaks new ground by studying statin effects for the first time in younger children with NF1 and co-morbid autism and by using multiparametric imaging outcomes. Methods: A single-site triple-blind RCT of simvastatin vs...
2018: Molecular Autism
https://www.readbyqxmd.com/read/29472099/neurotransmitter-activity-is-linked-to-outcome-following-subthalamic-deep-brain-stimulation-in-parkinson-s-disease
#6
Ruth L O'Gorman Tuura, Christian R Baumann, Heide Baumann-Vogel
INTRODUCTION: While the mechanisms underlying the therapeutic effects of deep brain stimulation (DBS) in Parkinson's Disease (PD) are not yet fully understood, DBS appears to exert a wide range of neurochemical effects on the network level, thought to arise from activation of inhibitory and excitatory pathways. The activity within the primary inhibitory (GABAergic) and excitatory (glutamatergic) neurotransmitter systems may therefore play an important role in the therapeutic efficacy of DBS in PD...
February 8, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29471227/the-impact-of-acute-and-short-term-methamphetamine-abstinence-on-brain-metabolites-a-proton-magnetic-resonance-spectroscopy-chemical-shift-imaging-study
#7
Antoinette Burger, Samantha J Brooks, Dan J Stein, Fleur M Howells
BACKGROUND: Abuse of methamphetamine (MA) is a global health concern. Previous1 H-MRS studies have found that, with methamphetamine abstinence (MAA), there are changes in n-acetyl-aspartate (NAA/Cr), myo-inositol (mI/Cr), choline (Cho/Cr and Cho/NAA), and glutamate with glutamine (Glx) metabolites. Limited studies have investigated the effect of acute MAA, and acute-to-short-term MAA on brain metabolites. METHODS: Adults with chronic MA dependence (n = 31) and healthy controls (n = 22) were recruited...
February 19, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29463154/evaluation-of-changes-in-biochemical-composition-of-fetal-brain-between-18th-and-40th-gestational-week-in-proton-magnetic-resonance-spectroscopy
#8
Andrzej Urbanik, Monika Cichocka, Justyna Kozub, Paulina Karcz, Izabela Herman-Sucharska
INTRODUCTION: The aim of this study is to determine the right1 H MRS spectra of the brain in fetuses of different age, and then to define what metabolic changes occur between 18th and 40th weeks of pregnancy. METHODS: 1 H MRS studies of 32 fetuses aged 18-40 gestational weeks were performed, in which the MRI excluded central nervous system malformations. The studied group included 11 fetuses aged 18-25 weeks (the second half of the second trimester), 14 fetuses aged 26-33 weeks (the first half of the third trimester), and seven fetuses aged 34-40 weeks (the second half of the third trimester)...
February 20, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29427395/minimum-echo-time-press-based-proton-observed-carbon-edited-poce-mrs-in-rat-brain-using-simultaneous-editing-and-localization-pulses
#9
Chathura Kumaragamage, Dan Madularu, Axel P Mathieu, Derek Lupinsky, Robin A de Graaf, Jamie Near
PURPOSE: Indirect 13 C MRS by proton-observed carbon editing (POCE) is a powerful method to study brain metabolism. The sensitivity of POCE-MRS can be enhanced through the use of short TEs, which primarily minimizes homonuclear J-evolution related losses; previous POCE-MRS implementations use longer than optimal echo times due to sequence limitations, or short TE image selected in vivo spectroscopy-based multi-shot acquisitions for 3D localization. To that end, this paper presents a novel single-shot point resolved spectroscopy (PRESS)-localized POCE-MRS sequence that involves the application of simultaneous editing and localization pulses (SEAL)-PRESS, allowing the TE to be reduced to a theoretically optimal value of ∼ 1/JHC ...
February 9, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29414127/striatal-neurometabolite-levels-in-patients-with-schizophrenia-undergoing-long-term-antipsychotic-treatment-a-proton-magnetic-resonance-spectroscopy-and-reliability-study
#10
Eric Plitman, Sofia Chavez, Shinichiro Nakajima, Yusuke Iwata, Jun Ku Chung, Fernando Caravaggio, Julia Kim, Youssef Alshehri, M Mallar Chakravarty, Vincenzo De Luca, Gary Remington, Philip Gerretsen, Ariel Graff-Guerrero
Previous proton magnetic resonance spectroscopy (1H-MRS) studies have reported disrupted levels of various neurometabolites in patients with schizophrenia. An area of particular interest within this patient population is the striatum, which is highly implicated in the pathophysiology of schizophrenia. The present study examined neurometabolite levels in the striatum of 12 patients with schizophrenia receiving antipsychotic treatment for at least 1 year and 11 healthy controls using 3-Tesla 1H-MRS (PRESS, TE = 35 ms)...
January 31, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29414126/proton-magnetic-resonance-spectroscopy-changes-after-lithium-treatment-systematic-review
#11
REVIEW
Agata Szulc, Magdalena Wiedlocha, Napoleon Waszkiewicz, Beata Galińska-Skok, Piotr Marcinowicz, Jacek Gierus, Anna Mosiolek
1H MRS is widely used in the research of mental disorders. It enables evaluation of concentration or ratios of several metabolites, which play important roles in brain metabolism: N-acetylaspartate (NAA), choline containing compounds, myo-inositol and glutamate, glutamine and GABA (together as Glx complex or separately). Specifically in bipolar disorder brain metabolite abnormalities include mostly NAA reduces and Glx increases in different brain regions. Bipolar disorder is associated with impairment in neurotrophic and cellular plasticity, resilience pathways and in neuroprotective processes...
January 17, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29391242/sex-and-sex-hormone-related-variations-in-energy-metabolic-frontal-brain-asymmetries-a-magnetic-resonance-spectroscopy-study
#12
Helene Hjelmervik, Markus Hausmann, Marco Hirnstein, Alexander R Craven, Kenneth Hugdahl, Karsten Specht
Creatine is a key regulator of brain energy homeostasis, and well-balanced creatine metabolism is central in healthy brain functioning. Still, the variability of brain creatine metabolism is largely unattended in magnetic resonance spectroscopy (MRS) research. In the human brain, marginal sex differences in creatine levels have been found in the prefrontal cortex. It is however not known to what degree these sex differences are stable or change with varying gonadal hormone levels. The current study therefore investigated creatine in the prefrontal cortex across the menstrual cycle...
January 29, 2018: NeuroImage
https://www.readbyqxmd.com/read/29390267/rehabilitation-program-based-on-sensorimotor-recovery-improves-the-static-and-dynamic-balance-and-modifies-the-basal-ganglia-neurochemistry-a-pilot-1h-mrs-study-on-parkinson-s-disease-patients
#13
Stefano Delli Pizzi, Rosa Grazia Bellomo, Simona Maria Carmignano, Emilio Ancona, Raffaella Franciotti, Marco Supplizi, Giovanni Barassi, Marco Onofrj, Laura Bonanni, Raoul Saggini
Rehabilitation interventions represent an alternative strategy to pharmacological treatment in order to slow or reverse some functional aspects of disability in Parkinson's disease (PD). To date, the neurophysiological mechanisms underlying rehabilitation-mediated improvement in PD patients are still poorly understood. Interestingly, growing evidence has highlighted a key role of the glutamate in neurogenesis and brain plasticity. The brain levels of glutamate, and of its precursor glutamine, can be detected in vivo and noninvasively as "Glx" by means of proton magnetic resonance spectroscopy (H-MRS)...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29383178/predictive-value-of-1h-mr-spectroscopy-and-18f-fdg-pet-ct-for-local-control-of-advanced-oropharyngeal-and-hypopharyngeal-squamous-cell-carcinoma-receiving-chemoradiotherapy-a-prospective-study
#14
Chih-Hua Yeh, Gigin Lin, Jiun-Jie Wang, Chien-Yu Lin, Shang-Yueh Tsai, Yu-Chun Lin, Yi-Ming Wu, Sheung-Fat Ko, Hung-Ming Wang, Sheng-Chieh Chan, Tzu-Chen Yen, Chun-Ta Liao, Shu-Hang Ng
Purpose: To determine whether pretreatment in vivo 1H magnetic resonance (MR) spectroscopy at 3 Tesla (T) and 18F-FDG PET/CT can offer predictive power regarding the local control of oropharyngeal or hypopharyngeal squamous cell carcinoma (OHSCC) patients. Materials and Methods: 1H MR spectroscopy was performed in addition to conventional MR imaging before definitive chemoradiotherapy in 58 patients with advanced OHSCC. The relationship of local control with the 1H MR spectroscopy and 18F-FDG PET/CT parameters was analyzed...
December 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29378291/glutamine-glutamate-glx-concentration-in-prefrontal-cortex-predicts-reversal-learning-performance-in-the-marmoset
#15
Agnès Lacreuse, Constance M Moore, Matthew LaClair, Laurellee Payne, Jean A King
This study used Magnetic Resonance Spectroscopy (MRS) to identify potential neurometabolitic markers of cognitive performance in male (n =7) and female (n=8) middle-aged (~5 years old) common marmosets (Callithrix jacchus). Anesthetized marmosets were scanned with a 4.7 T/40cm horizontal magnet equipped with 450 mT/m magnetic field gradients and a 20-G/cm magnetic field gradient insert, within 3 months of completing the CANTAB serial Reversal Learning task. Neurometabolite concentrations of N-Acetyl Asparate, Myo-Inositol, Choline, Phosphocreatine+creatine, Glutamate and Glutamine were acquired from a 3 mm3 voxel positioned in the Prefrontal Cortex (PFC)...
January 26, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29377412/high-fat-diet-induces-a-neurometabolic-state-characterized-by-changes-in-glutamate-and-n-acetylaspartate-pools-associated-with-early-glucose-intolerance-an-in-vivo-multimodal-mri-study
#16
Mário Ribeiro, João Castelhano, Lorena I Petrella, José Sereno, Tiago Rodrigues, Christian Neves, Liliana Letra, Filipa I Baptista, Raquel Seiça, Paulo Matafome, Miguel Castelo-Branco
BACKGROUND: Type-2 diabetes mellitus (T2DM) is a metabolic disorder with a broad range of complications in the brain that depend on the conditions that precede its onset, such as obesity and metabolic syndromes. It has been suggested that neurotransmitter and metabolic perturbations may emerge even before the early stages of T2DM and that high-caloric intake could adversely influence the brain in such states. Notwithstanding, evidence for neurochemical and structural alterations in these conditions are still sparse and controversial...
January 26, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29306050/glutamate-quantification-by-press-or-mega-press-validation-repeatability-and-concordance
#17
Tamar M van Veenendaal, Walter H Backes, Frank C G van Bussel, Richard A E Edden, Nicolaas A J Puts, Albert P Aldenkamp, Jacobus F A Jansen
PURPOSE: While PRESS is often employed to measure glutamate concentrations, MEGA-PRESS enables simultaneous Glx (glutamate and glutamine) and GABA measurements. This study aimed to compare validation, repeatability, and concordance of different approaches for glutamate quantification at 3T to aid future studies in their selection of the appropriate sequence and quantification method. MATERIALS AND METHODS: Nine phantoms with different glutamate and glutamine concentrations and five healthy participants were scanned twice to assess respectively the validation and repeatability of measurements with PRESS and MEGA-PRESS...
May 2018: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29279021/increased-myo-inositol-in-primary-motor-cortex-of-contact-sports-athletes-without-a-history-of-concussion
#18
Geneviève Lefebvre, Emilie Chamard, Sébastien Proulx, Sara Tremblay, Mark Halko, Salil Soman, Elaine de Guise, Alvaro Pascual-Leone, Hugo Théoret
The objective of the study was to determine whether repetitive hits to the head at a subclinical level are associated with structural and functional brain abnormalities and whether these effects are influenced by high levels of fitness associated with intense physical activity. Seventy-two college students were recruited: 24 nonathletic, 24 athletes practicing a varsity contact sport, and 24 athletes practicing a varsity noncontact sport. They were recruited for a neuropsychological evaluation and a magnetic resonance imaging session that included magnetic resonance spectroscopy of primary motor cortex (M1) and prefrontal cortex and susceptibility-weighted imaging...
February 9, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29259538/reliability-of-glutamate-quantification-in-human-nucleus-accumbens-using-proton-magnetic-resonance-spectroscopy-at-a-70-cm-wide-bore-clinical-3t-mri-system
#19
Xi-Long Liu, Long Li, Jian-Neng Li, Jia-Hui Rong, Bo Liu, Ze-Xuan Hu
The human nucleus accumbens is a challenging region to study using proton magnetic resonance spectroscopy (1 H-MRS) on a 70-cm wide-bore clinical 3T MRI system. The aim of this study was to investigate the reliability for quantitative measurement of glutamate concentration in the nucleus accumbens using a 70-cm wide-bore clinical 3T MRI.1 H-MRS of the nucleus accumbens was acquired using the Point-Resolved Spectroscopic Sequence (PRESS) with echo time of 40 ms from 10 healthy volunteers (5 female; age range: 18-30 years) on two separate visits (a baseline, and 1-month time point)...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29242361/measuring-cerebral-and-cerebellar-glutathione-in-children-using-1-h-mega-press-mrs
#20
F Raschke, R Noeske, R A Dineen, D P Auer
BACKGROUND AND PURPOSE: Glutathione is an important antioxidant in the human brain and therefore of interest in neurodegenerative disorders. The purpose of this study was to investigate the feasibility of measuring glutathione in healthy nonsedated children by using the1 H Mescher-Garwood point-resolved spectroscopy (MEGA-PRESS) sequence at 3T and to compare glutathione levels between the medial parietal gray matter and the cerebellum. MATERIALS AND METHODS: Glutathione was measured using MEGA-PRESS MRS (TR = 1...
February 2018: AJNR. American Journal of Neuroradiology
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