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https://www.readbyqxmd.com/read/29907927/-1-h-mrs-spectroscopy-in-preclinical-autosomal-dominant-alzheimer-disease
#1
Elizabeth Joe, Luis D Medina, John M Ringman, Joseph O'Neill
1 H magnetic resonance spectroscopy (MRS) can reveal changes in brain biochemistry in vivo in humans and has been applied to late onset Alzheimer disease (AD). Carriers of mutations for autosomal dominant Alzheimer disease (ADAD) may show changes in levels of metabolites prior to the onset of clinical symptoms. Proton MR spectra were acquired at 1.5 T for 16 cognitively asymptomatic or mildly symptomatic mutation carriers (CDR < 1) and 11 non-carriers as part of a comprehensive cross-sectional study of preclinical ADAD...
June 16, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29893995/on-the-relation-between-mr-spectroscopy-features-and-the-distance-to-mri-visible-solid-tumor-in-gbm-patients
#2
Nuno Pedrosa de Barros, Raphael Meier, Martin Pletscher, Samuel Stettler, Urspeter Knecht, Evelyn Herrmann, Philippe Schucht, Mauricio Reyes, Jan Gralla, Roland Wiest, Johannes Slotboom
PURPOSE: To improve the detection of peritumoral changes in GBM patients by exploring the relation between MRSI information and the distance to the solid tumor volume (STV) defined using structural MRI (sMRI). METHODS: Twenty-three MRSI studies (PRESS, TE 135 ms) acquired from different patients with untreated GBM were used in this study. For each MRSI examination, the STV was identified by segmenting the corresponding sMRI images using BraTumIA, an automatic segmentation method...
June 12, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29893645/changes-in-brain-metabolite-concentrations-after-neonatal-hypoxic-ischemic-encephalopathy
#3
Jun Shibasaki, Noriko Aida, Naho Morisaki, Moyoko Tomiyasu, Yuri Nishi, Katsuaki Toyoshima
Purpose To investigate the time-course changes and predictive utility of brain metabolite concentrations in neonatal hypoxic-ischemic encephalopathy (HIE). Materials and Methods Sixty-eight neonates (age, 35-41 gestational weeks) with HIE were admitted to a neonatal intensive care unit between September 2009 and March 2016 and examined by using proton MR spectroscopy at 18-96 hours (n = 25) and 7-14 days (n = 64) after birth (35-43 postmenstrual weeks) to estimate metabolite concentrations in the deep gray matter...
June 12, 2018: Radiology
https://www.readbyqxmd.com/read/29885049/diurnal-changes-in-glutamate-glutamine-levels-of-healthy-young-adults-assessed-by-proton-magnetic-resonance-spectroscopy
#4
Carina Volk, Valeria Jaramillo, Renato Merki, Ruth O'Gorman Tuura, Reto Huber
The glutamatergic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor is involved in synaptic plasticity processes, and animal studies have demonstrated altered expression across the sleep wake cycle. Accordingly, glutamate levels are reduced during non-rapid eye movement (NREM) sleep and the rate of this decrease is positively correlated with sleep EEG slow wave activity (SWA). Here, we combined proton magnetic resonance spectroscopy (1 H-MRS) and high-density sleep EEG to assess if 1 H-MRS is sensitive to diurnal changes of glutamate + glutamine (GLX) in healthy young adults and if potential overnight changes of GLX are correlated to SWA...
June 8, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29860500/intralipid-heparin-infusion-alters-the-brain-metabolites-assessed-with-1h-mrs-spectroscopy-in-young-healthy-men
#5
Monika Karczewska-Kupczewska, Agnieszka Nikolajuk, Remigiusz Filarski, Radoslaw Majewski, Eugeniusz Tarasów
Context: We previously demonstrated that insulin infusion altered the metabolite concentrations in cerebral tissues, assessed with proton magnetic resonance spectroscopy (1H-MRS) in young subjects with high insulin sensitivity, but not with low insulin sensitivity. Fat overload is an important factor leading to insulin resistance. Objective: The purpose of the present study was to examine the effect of circulating free fatty acids (FFA) elevation on the metabolites in cerebral tissues, assessed with 1H-MRS...
April 20, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29852189/supra-physiological-concentration-of-glyoxylate-inhibits-proliferation-of-human-colon-cancer-cells-through-oxidative-stress
#6
Tapas Patra, Paramita Ghosh, Neyaz Alam, Nabendu Murmu
AIMS: The cytotoxic response of an intermediate metabolite glyoxylate (Glx) on colon carcinoma has been evaluated in vitro. MAIN METHODS: The anti-proliferative effect of Glx was assessed on HT-29 and HCT-116 cells by performing MTT assay as well as beta-hexosaminidase assay. Evaluation of apoptotic event of Glx treated cells was measured by flow cytometry using annexin-V/PI staining. The mitochondrial membrane potential and level of ROS were estimated using DiOC6 (3)/CCCP and DCFH-DA method, respectively...
May 28, 2018: Life Sciences
https://www.readbyqxmd.com/read/29802602/dependence-on-subconcussive-impacts-of-brain-metabolism-in-collision-sport-athletes-an-mr-spectroscopic-study
#7
Sumra Bari, Diana O Svaldi, Ikbeom Jang, Trey E Shenk, Victoria N Poole, Taylor Lee, Ulrike Dydak, Joseph V Rispoli, Eric A Nauman, Thomas M Talavage
Long term neurological impairments due to repetitive head trauma are a growing concern for collision sport athletes. American Football has the highest rate of reported concussions among male high school athletes, a position held by soccer for female high school athletes. Recent research has shown that subconcussive events experienced by collision sport athletes can be a further significant source of accrued damage. Collision sport athletes experience hundreds of subconcussive events in a single season, and these largely go uninvestigated as they produce no overt clinical symptoms...
May 25, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29794260/spectroscopic-differences-in-posterior-insula-in-patients-with-chronic-temporomandibular-pain
#8
Kristin Harfeldt, Louise Alexander, Julia Lam, Sven Månsson, Hans Westergren, Peter Svensson, Pia C Sundgren, Per Alstergren
BACKGROUND AND AIMS: Chronic pain including temporomandibular disorder (TMD) pain involves a complex interplay between peripheral and central sensitization, endogenous modulatory pathways, cortical processing and integration and numerous psychological, behavioral and social factors. The aim of this study was to compare spectroscopic patterns of N-Acetyl-aspartate (NAA), total creatine (tCr), choline (Cho), myo-inositol (MI), glutamate (Glu), and the combination of Glu and glutamine in the posterior insula in patients with chronic generalized or regional chronic TMD pain (gTMD and rTMD, respectively) compared to healthy individuals (HI) in relation to clinical findings of TMD pain...
April 13, 2018: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29789269/anterior-cingulate-cortex-glutamatergic-metabolites-and-mood-stabilizers-in-euthymic-bipolar-i-disorder-patients-a-proton-magnetic-resonance-spectroscopy-study
#9
Marcio Gerhardt Soeiro-de-Souza, Maria Concepcion Garcia Otaduy, Rodrigo Machado-Vieira, Ricardo Alberto Moreno, Fabiano G Nery, Claudia Leite, Beny Lafer
BACKGROUND: Bipolar disorder is a chronic and recurrent illness characterized by depressive and manic episodes. Proton magnetic resonance spectroscopy (1 H-MRS) studies have demonstrated glutamate (Glu) system abnormalities in BD, but it is unclear how Glu varies among mood states and how medications modulate it. The objective of this study was to investigate the influence of mood stabilizers on anterior cingulate cortex Glu levels using 1 H-MRS during euthymia. METHODS: One hundred twenty-eight bipolar I disorder (BDI) euthymic subjects and 80 healthy control subjects underwent 3T brain 1 H-MRS imaging examination including acquisition of an anterior cingulate cortex single voxel (8 cm3 ) 1 H-MRS, based on a point resolved spectroscopy (PRESS) sequence with an echo time of 80 ms and a repetition time of 1500 ms (BIPUSP MRS study)...
March 31, 2018: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/29706886/lower-choline-and-myo-inositol-in-temporo-parietal-cortex-is-associated-with-apathy-in-amnestic-mci
#10
Shankar Tumati, Esther M Opmeer, Jan-Bernard C Marsman, Sander Martens, Fransje E Reesink, Peter P De Deyn, André Aleman
Apathy is a common symptom in patients with amnestic mild cognitive impairment (aMCI) and is associated with an increased risk of progression to Alzheimer's disease (AD). The neural substrates underlying apathy in aMCI may involve multiple brain regions, including the anterior cingulate cortex and the temporo-parietal region. Here we investigated neurometabolites in brain regions that may underlie apathy in aMCI patients using proton magnetic resonance spectroscopy (1 H-MRS). Twenty-eight aMCI patients with varying degrees of apathy and 20 matched controls underwent 1 H-MRS...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29518282/positron-emission-tomography-guided-magnetic-resonance-spectroscopy-in-alzheimer-disease
#11
Nasim Sheikh-Bahaei, S Ahmad Sajjadi, Roido Manavaki, Mary McLean, John T O'Brien, Jonathan H Gillard
OBJECTIVE: To determine whether the level of metabolites in magnetic resonance spectroscopy (MRS) is a representative marker of underlying pathological changes identified in positron emission tomographic (PET) images in Alzheimer disease (AD). METHODS: We performed PET-guided MRS in cases of probable AD, mild cognitive impairment (MCI), and healthy controls (HC). All participants were imaged by 11 C-Pittsburgh compound B (11 C-PiB) and 18 F-fluorodeoxyglucose (18 F-FDG) PET followed by 3T MRS...
April 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29511334/psychostimulant-drug-effects-on-glutamate-glx-and-creatine-in-the-anterior-cingulate-cortex-and-subjective-response-in-healthy-humans
#12
Tara L White, Mollie A Monnig, Edward G Walsh, Adam Z Nitenson, Ashley D Harris, Ronald A Cohen, Eric C Porges, Adam J Woods, Damon G Lamb, Chelsea A Boyd, Sinda Fekir
Prescription psychostimulants produce rapid changes in mood, energy, and attention. These drugs are widely used and abused. However, their effects in human neocortex on glutamate and glutamine (pooled as Glx), and key neurometabolites such as N-acetylaspartate (tNAA), creatine (tCr), choline (Cho), and myo-inositol (Ins) are poorly understood. Changes in these compounds could inform the mechanism of action of psychostimulant drugs and their abuse potential in humans. We investigated the acute impact of two FDA-approved psychostimulant drugs on neurometabolites using magnetic resonance spectroscopy (1 H MRS)...
June 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29506576/effects-of-isoflurane-sevoflurane-propofol-and-alfaxalone-on-brain-metabolism-in-dogs-assessed-by-proton-magnetic-resonance-spectroscopy-1-h-mrs
#13
Franz Josef Söbbeler, Inés Carrera, Kirby Pasloske, Millagahamada Gedara Ranasinghe, Patrick Kircher, Sabine Beate Rita Kästner
BACKGROUND: The purpose of this study was to determine the effects of isoflurane, sevoflurane, propofol and alfaxalone on the canine brain metabolite bioprofile, measured with single voxel short echo time proton magnetic resonance spectroscopy at 3 Tesla. Ten adult healthy Beagle dogs were assigned to receive isoflurane, sevoflurane, propofol and alfaxalone at 3 different dose rates each in a randomized cross-over study design. Doses for isoflurane, sevoflurane, propofol and alfaxalone were FE 'Iso 1...
March 5, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29488277/the-increase-in-medial-prefrontal-glutamate-glutamine-concentration-during-memory-encoding-is-associated-with-better-memory-performance-and-stronger-functional-connectivity-in-the-human-medial-prefrontal-thalamus-hippocampus-network
#14
Jan-Willem Thielen, Donghyun Hong, Seyedmorteza Rohani Rankouhi, Jens Wiltfang, Guillén Fernández, David G Norris, Indira Tendolkar
The classical model of the declarative memory system describes the hippocampus and its interactions with representational brain areas in posterior neocortex as being essential for the formation of long-term episodic memories. However, new evidence suggests an extension of this classical model by assigning the medial prefrontal cortex (mPFC) a specific, yet not fully defined role in episodic memory. In this study, we utilized 1H magnetic resonance spectroscopy (MRS) and psychophysiological interaction (PPI) analysis to lend further support for the idea of a mnemonic role of the mPFC in humans...
June 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29484149/randomised-controlled-trial-of-simvastatin-treatment-for-autism-in-young-children-with-neurofibromatosis-type-1-santa
#15
Stavros Stivaros, Shruti Garg, Maria Tziraki, Ying Cai, Owen Thomas, Joseph Mellor, Andrew A Morris, Carly Jim, Karolina Szumanska-Ryt, Laura M Parkes, Hamied A Haroon, Daniela Montaldi, Nicholas Webb, John Keane, Francisco X Castellanos, Alcino J Silva, Sue Huson, Stephen Williams, D Gareth Evans, Richard Emsley, Jonathan Green
Background: Neurofibromatosis 1 (NF1) is a monogenic model for syndromic autism. Statins rescue the social and cognitive phenotype in animal knockout models, but translational trials with subjects > 8 years using cognition/behaviour outcomes have shown mixed results. This trial breaks new ground by studying statin effects for the first time in younger children with NF1 and co-morbid autism and by using multiparametric imaging outcomes. Methods: A single-site triple-blind RCT of simvastatin vs...
2018: Molecular Autism
https://www.readbyqxmd.com/read/29472099/neurotransmitter-activity-is-linked-to-outcome-following-subthalamic-deep-brain-stimulation-in-parkinson-s-disease
#16
Ruth L O'Gorman Tuura, Christian R Baumann, Heide Baumann-Vogel
INTRODUCTION: While the mechanisms underlying the therapeutic effects of deep brain stimulation (DBS) in Parkinson's Disease (PD) are not yet fully understood, DBS appears to exert a wide range of neurochemical effects on the network level, thought to arise from activation of inhibitory and excitatory pathways. The activity within the primary inhibitory (GABAergic) and excitatory (glutamatergic) neurotransmitter systems may therefore play an important role in the therapeutic efficacy of DBS in PD...
May 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29471227/the-impact-of-acute-and-short-term-methamphetamine-abstinence-on-brain-metabolites-a-proton-magnetic-resonance-spectroscopy-chemical-shift-imaging-study
#17
Antoinette Burger, Samantha J Brooks, Dan J Stein, Fleur M Howells
BACKGROUND: Abuse of methamphetamine (MA) is a global health concern. Previous 1 H-MRS studies have found that, with methamphetamine abstinence (MAA), there are changes in n-acetyl-aspartate (NAA/Cr), myo-inositol (mI/Cr), choline (Cho/Cr and Cho/NAA), and glutamate with glutamine (Glx) metabolites. Limited studies have investigated the effect of acute MAA, and acute-to-short-term MAA on brain metabolites. METHODS: Adults with chronic MA dependence (n = 31) and healthy controls (n = 22) were recruited...
April 1, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29463154/evaluation-of-changes-in-biochemical-composition-of-fetal-brain-between-18th-and-40th-gestational-week-in-proton-magnetic-resonance-spectroscopy
#18
Andrzej Urbanik, Monika Cichocka, Justyna Kozub, Paulina Karcz, Izabela Herman-Sucharska
INTRODUCTION: The aim of this study is to determine the right 1 H MRS spectra of the brain in fetuses of different age, and then to define what metabolic changes occur between 18th and 40th weeks of pregnancy. METHODS: 1 H MRS studies of 32 fetuses aged 18-40 gestational weeks were performed, in which the MRI excluded central nervous system malformations. The studied group included 11 fetuses aged 18-25 weeks (the second half of the second trimester), 14 fetuses aged 26-33 weeks (the first half of the third trimester), and seven fetuses aged 34-40 weeks (the second half of the third trimester)...
February 20, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29427395/minimum-echo-time-press-based-proton-observed-carbon-edited-poce-mrs-in-rat-brain-using-simultaneous-editing-and-localization-pulses
#19
Chathura Kumaragamage, Dan Madularu, Axel P Mathieu, Derek Lupinsky, Robin A de Graaf, Jamie Near
PURPOSE: Indirect 13 C MRS by proton-observed carbon editing (POCE) is a powerful method to study brain metabolism. The sensitivity of POCE-MRS can be enhanced through the use of short TEs, which primarily minimizes homonuclear J-evolution related losses; previous POCE-MRS implementations use longer than optimal echo times due to sequence limitations, or short TE image selected in vivo spectroscopy-based multi-shot acquisitions for 3D localization. To that end, this paper presents a novel single-shot point resolved spectroscopy (PRESS)-localized POCE-MRS sequence that involves the application of simultaneous editing and localization pulses (SEAL)-PRESS, allowing the TE to be reduced to a theoretically optimal value of ∼ 1/JHC ...
February 9, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29414127/striatal-neurometabolite-levels-in-patients-with-schizophrenia-undergoing-long-term-antipsychotic-treatment-a-proton-magnetic-resonance-spectroscopy-and-reliability-study
#20
Eric Plitman, Sofia Chavez, Shinichiro Nakajima, Yusuke Iwata, Jun Ku Chung, Fernando Caravaggio, Julia Kim, Youssef Alshehri, M Mallar Chakravarty, Vincenzo De Luca, Gary Remington, Philip Gerretsen, Ariel Graff-Guerrero
Previous proton magnetic resonance spectroscopy (1 H-MRS) studies have reported disrupted levels of various neurometabolites in patients with schizophrenia. An area of particular interest within this patient population is the striatum, which is highly implicated in the pathophysiology of schizophrenia. The present study examined neurometabolite levels in the striatum of 12 patients with schizophrenia receiving antipsychotic treatment for at least 1 year and 11 healthy controls using 3-Tesla 1 H-MRS (PRESS, TE = 35 ms)...
March 30, 2018: Psychiatry research. Neuroimaging
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